CN105125736A - Composition with effects of protecting liver and improving eyesight and preparation method thereof - Google Patents
Composition with effects of protecting liver and improving eyesight and preparation method thereof Download PDFInfo
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- CN105125736A CN105125736A CN201510566343.9A CN201510566343A CN105125736A CN 105125736 A CN105125736 A CN 105125736A CN 201510566343 A CN201510566343 A CN 201510566343A CN 105125736 A CN105125736 A CN 105125736A
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Abstract
The invention relates to the technical field of medical care, in particular to a composition with effects of protecting the liver and improving eyesight and a preparation method thereof. The composition mainly comprises mulberry, Chinese wolfberry fruit, chrysanthemum, mulberry leaf and lutein and/or lutein derivative. The composition has the advantages that medicinal and edible raw materials are carefully selected and reasonably combined to achieve a compound synergic effect, retinal damage can be effectively prevented by inhibiting oxidative stress reaction, an evident visual fatigue relieving effect is achieved, and immunity is increased; meanwhile, a definite liver damage preventing effect is achieved, the definite curative effects of protecting the liver and improving the eyesight are achieved, and the composition is free of toxic and side effects on human bodies, suitable for being eaten for a long time and capable of achieving beneficial effect of treatment and healthcare two-way regulation.
Description
Technical field
The present invention relates to medicines and health protection technical field, particularly a kind of composition and method of making the same with liver-nourishing and eyesight-improving effect.
Background technology
China's ophthalmic diseases situation is on the rise, and the poor sight patient of relevant data display China, more than 400,000,000 people, occupies first of the world.Modern society's competition is more and more fierce, has excessively become the life normality of a lot of people with eye.A lot of people has to staying up late, working overtime and reading for a long time as a kind of normality, thus, eyes must bear huge pressure, if things go on like this, very likely suffer from myopia, particularly the computer work proportion that accounts in modern metropolitan cities is increasing, further increases myopic probability, so that up till now, myopia is still topmost ocular disease.
" retinal diseases ", refers to any condition of illness of to be caused by oxidative stress or increase the weight of amphiblestroid or the tissue around it.These condition of illness comprise degeneration of macula, diabetic retinopathy, choroidal neovascularization, macular edema (being also called cystoid macular edema and macula lutea swelling), preretinal membrane (macular pucker), macular hole, retinitis pigmentosa, macular dystrophy is (as Stargardt juvenile stage degeneration of macula, bass Te Shi (Best ' s) yolk shape malnutrition, Progressive cone dystrophy, and the diagram shape malnutrition of retinal pigment epithelium), detachment of retina, retina wound, Retinal neoplasms and retinal diseases associated with it, congenital hypertrophy of retinal pigmented epithelium, acute multifocal ischemic choroidopathy, and acute retinal pigment epithelitis.Scotopic retinal rod photoreceptor causes very high metabolic demand (i.e. energy expenditure (ATP consumption) and oxygen consumption).The anoxia caused can cause and/or aggravate retinal degeneration, this degeneration may worsen when retinal vasculature is impaired, described retinal degeneration includes but not limited to following condition of illness, such as diabetic renal papillary necrosis, macular edema, diabetic maculopathy, retinal vascular occlusion (it comprises retinal vein occlusion and retinal arterial obstruction), retinopathy of prematurity, ischemia-reperfusion dependency retina injury and wet age-related macular degeneration (AMD).In addition, retinal degeneration and anoxia can cause new vessels to be formed, and the latter may make again the worsening degree of retinal degeneration.Along with the raising of people's vision care consciousness, quick acting, the eye care product of efficacy consolidation will have wide market prospect.
The medicine of the common releasing asthenopia of existing market, treatment retina relevant disease fundamentally can not solve the problem of ophthalmic diseases.What market obtains official approval is that the health food kind of effect is more with liver heat removing and eyesight improving, but rare in accordance with tcm theory prescription, exact efficacy, stable and controllable for quality, health food safe and convenient to use.The health tea of existing liver heat removing and eyesight improving, often component is numerous for they, but prescription is composite and consumption is unreasonable, also there is the stability problem that health food should be noted that the toxic and side effects problem that life-time service produces and long-term storage.Existing a lot of product does not notice the relevant issues of life-time service when selecting component, long-term taking easily produces ill effect or stability is not good.
Chinese invention patent publication number CN102919921A discloses a kind of beverage made of fruits or vegetables, be Main Ingredients and Appearance by Sucus Canarii, Folium Nelumbinis juice, Rhizoma Imperatae juice, these three kinds of raw materials are medicine and food raw materials, and nectar also can add vitamin, and wherein vitamin selected vitamin comprises vitamin A, vitamin B
1, vitamin B
2, vitamin B
6, vitamin B
12, one or more in vitamin C.Also can add the Chinese medicine extract that extracting method is routinely obtained, these Chinese medicine extract comprise: one or more in Flos Chrysanthemi, Flos Lonicerae, Folium Mori, Fructus Lycii, Rhizoma Polygonati, Fructus Mori, Pericarpium Citri tangerinae.This beverage made of fruits or vegetables can make consumer also can reach certain dietetic therapy anti-radiation health care effect drinking nectar while.
Chinese invention patent publication number CN102366009A discloses a kind of clearing away heat to improve acuity of vision health preserving tea, and its primary raw material is: Flos Chrysanthemi, Fructus Lycii, Fructus Mori, Semen Cassiae, Radix Rehmanniae, crystal sugar; There is heat-clearing and toxic substances removing, removing heat from blood, liver heat removing and eyesight improving, loosening bowel to relieve constipation, YIN nourishing and the production of body fluid promoting function.
Chinese invention patent publication number CN102204615A discloses a kind of Sang Ju Yin health tea, belong to field of beverage, include Fructus Mori, Flos Chrysanthemi, Flos Lonicerae, Semen Cassiae, Mel, sugar, Fructus Lycii, citric acid, vitamin and pure water, there is fatigue alleviating, promote the function such as people's physical and mental health, remitting vision fatigue, nourishing.
But the product related in above-mentioned patent alleviating asthenopia, prevent and treat retinal diseases and curative effect in protecting the liver very micro-.Therefore a kind of can effectively alleviating asthenopia, control retinal diseases and the medicine protected the liver and health food having important practical significance is researched and developed.
Summary of the invention
In view of this, the invention provides a kind of composition and method of making the same of liver-nourishing and eyesight-improving effect.Said composition passes through prescription and the reasonable compatibility of selected integration of edible and medicinal herbs, the combination of compound synergic is obtained from raw material and composition aspect, in some embodiments, use the compositions with liver-nourishing and eyesight-improving effect described herein, can prevent, suppress and/or postpone the dark adaptation of rod cell, and therefore reduce the demand of metabolism, thus alleviate anoxia and suppress new vessels to be formed, prevent and/or treat retinal diseases.By inhibited oxidation stress, effective preventive and therapeutic action is played to retina injury, create the effect of significant alleviating asthenopia, improve immunity; There is definite liver injury protection effect simultaneously, reach the definite curative effect of liver-nourishing and eyesight-improving, to human non-toxic's side effect, be applicable to long-term edible, the beneficial effect for the treatment of and health care two-ways regulation can be played.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of compositions, obtain primarily of following raw material:
Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives.
Fructus Mori, have another name called Mulberry reality, civil and military real, black mulberry, Mulberry Fructus Jujubae, Fructus Mori, and nature and flavor are sweet, flat, nontoxic.Composition: have volume carotene and tannin, reducing sugar, pentosan and galactose acid anhydride.Ripe mulberry fruit contains glucose, sugarcane grain, succinic acid, tartaric acid, vitamin B
1, B
2, C, nicotinic acid, pigment etc.Tonify deficiency QI invigorating, anhydrate gas.Cure mainly the having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence, soreness of waist tinnitus, early whitening of beard and hair, insomnia and dreamful sleep, Tianjin wound thirsty, quench one's thirst, dryness of the intestine constipation.Fructus Mori are improved skin (comprising scalp) blood supply, nutrition skin, make the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori are that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori have immunologic enhancement.Fructus Mori have effect of gain to spleen, have potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism.It can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori have the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulate enterokinesia and remove scorching.Motherland's medical science is thought, Fructus Mori are sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.
Fructus Lycii is traditional rare Chinese medicine, is again a kind of tonic food.As Chinese medicine, the flat sweet in the mouth of Fructus Lycii, has effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, lung moistening.Pass through chemical composition analysis, the fruit of Fructus Lycii detects containing nutritional labelings such as abundant carotene, vitamin C, Fructus Lycii proteoglycan, betanin, linoleic acid and ferrum, phosphorus, calcium, has tonify deficiency to calm the nerves, improving eyesight is dispeled the wind, the effect such as nourishing kidney lung moistening and hepatoprotective antitumor.
Flos Chrysanthemi, has another name called joint China, aurin, Flos Chrysanthemi, true chrysanthemum, Jin Rui, family chrysanthemum, steamed bread chrysanthemum, hairpin head chrysanthemum, Flos Chrysanthemi, medicine chrysanthemum, expelling wind and cold pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.Function cures mainly: dispelling wind, heat clearing away, improving eyesight, removing toxic substances.Control headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.
Folium Mori, bitter in the mouth, sweet, cold nature.Return lung, Liver Channel.Pulvis refrigerans falls.There is effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.
Phylloxanthin, has another name called " plant progesterone ", is extensively present in vegetable, flower, fruit, is the main component of macula lutea in eyes, can protects the vision of eyes; It is the primary pigments forming human eye retina's macular region.This element is that human body cannot manufacture, and absorption phylloxanthin must be relied on to supplement, but absorbance is lower, and excessive supplementary phylloxanthin can cause burden to liver.
The present invention passes through prescription and the reasonable compatibility of selected integration of edible and medicinal herbs, the combination of compound synergic is obtained from raw material and composition aspect, can prevent, suppress and/or postpone the dark adaptation of rod cell, and therefore reduce the demand of metabolism, thus alleviate anoxia and suppress new vessels to be formed, prevent and/or treat retinal diseases; By inhibited oxidation stress, effective protective effect is played to retina injury, create the effect of significant alleviating asthenopia; There is definite liver injury protection effect simultaneously, reach the definite curative effect of liver-nourishing and eyesight-improving, to human non-toxic's side effect, be applicable to long-term edible, the beneficial effect for the treatment of and health care two-ways regulation can be played.
As preferably, with parts by weight, Fructus Mori 1000 ~ 4000 parts, Fructus Lycii 1000 ~ 4000 parts, Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts.
Preferably, with parts by weight, Fructus Mori 2000 ~ 4000 parts, Fructus Lycii 2000 ~ 4000 parts, Flos Chrysanthemi 1000 ~ 3000 parts, 1000 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts.
In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 1000 parts, 1000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts.
In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 parts.
In embodiments more provided by the invention, with parts by weight, Fructus Mori 3000 parts, Fructus Lycii 3000 parts, Flos Chrysanthemi 2000 parts, 2000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts.
In embodiments more provided by the invention, with parts by weight, Fructus Mori 4000 parts, Fructus Lycii 4000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 15 parts.
Described in the present composition, xanthophyll derivatives is preferably lutein ester.In embodiments more provided by the invention, said composition can also comprise one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii.
Present invention also offers said composition preparing inhibited oxidation stress, the application prevented and treated in the medicine of retina injury or alleviating asthenopia or health food; Said composition obtains primarily of following raw material: Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives; As preferably, with parts by weight, Fructus Mori 1000 ~ 4000 parts, Fructus Lycii 1000 ~ 4000 parts, Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; Preferably, with parts by weight, Fructus Mori 2000 ~ 4000 parts, Fructus Lycii 2000 ~ 4000 parts, Flos Chrysanthemi 1000 ~ 3000 parts, 1000 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 1000 parts, 1000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 3000 parts, Fructus Lycii 3000 parts, Flos Chrysanthemi 2000 parts, 2000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 4000 parts, Fructus Lycii 4000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 15 parts; Described in the present composition, xanthophyll derivatives is preferably lutein ester.In embodiments more provided by the invention, said composition also comprises one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii.
Present invention also offers the application of said composition in preparation control liver injury medicament or health food; Said composition obtains primarily of following raw material: Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives; As preferably, with parts by weight, Fructus Mori 1000 ~ 4000 parts, Fructus Lycii 1000 ~ 4000 parts, Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; Preferably, with parts by weight, Fructus Mori 2000 ~ 4000 parts, Fructus Lycii 2000 ~ 4000 parts, Flos Chrysanthemi 1000 ~ 3000 parts, 1000 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 1000 parts, 1000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 3000 parts, Fructus Lycii 3000 parts, Flos Chrysanthemi 2000 parts, 2000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 4000 parts, Fructus Lycii 4000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 15 parts; Described in the present composition, xanthophyll derivatives is preferably lutein ester; In embodiments more provided by the invention, said composition also comprises one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii.
Present invention also offers the preparation method of said composition, adopt following a)-c) in one or more methods preparation, comprise the steps:
A) Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori are pulverized, obtain mixing major ingredient; By phylloxanthin and/or xanthophyll derivatives with mix major ingredient and mix, obtain compositions; Or
B) by Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori water extraction, concentrated, dry, obtain mixing major ingredient; By phylloxanthin and/or xanthophyll derivatives with mix major ingredient and mix, obtain compositions; Or
C) by Fructus Mori and Fructus Lycii Fructus Lycii mixing water extraction, alcohol settling, obtains polysaccharide precipitation;
By Folium Mori and Flos Chrysanthemi mixing water extraction, obtain water extract;
Water extract is mixed with polysaccharide precipitation, dry, obtain mixing major ingredient;
By phylloxanthin with mix major ingredient and mix, obtain compositions.
In preparation method of the present invention, by phylloxanthin and/or xanthophyll derivatives with mix the step also comprising pulverizing after major ingredient mixes; Pulverizing is specially and is crushed to more than fineness of the particles 100 order.
Present invention also offers a kind of product, this product is medicine or health food, and this product comprises adjuvant and compositions provided by the invention; Said composition obtains primarily of following raw material: Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives; As preferably, with parts by weight, Fructus Mori 1000 ~ 4000 parts, Fructus Lycii 1000 ~ 4000 parts, Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; Preferably, with parts by weight, Fructus Mori 2000 ~ 4000 parts, Fructus Lycii 2000 ~ 4000 parts, Flos Chrysanthemi 1000 ~ 3000 parts, 1000 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 1000 parts, 1000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 3000 parts, Fructus Lycii 3000 parts, Flos Chrysanthemi 2000 parts, 2000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 4000 parts, Fructus Lycii 4000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 15 parts; Described in the present composition, xanthophyll derivatives is preferably lutein ester; In embodiments more provided by the invention, said composition also comprises one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii; Adjuvant is acceptable adjuvant in pharmaceutically acceptable adjuvant or bromatology.
As preferably, the dosage form of medicine is tablet, capsule, medicinal tea, granule, effervescent tablet, buccal tablet, disintegrating tablet or pill.But the dosage form of medicine of the present invention is not defined in this, those skilled in the art think that feasible dosage form is all within protection scope of the present invention, and the present invention is in this no limit.
Present invention also offers a kind of health food, comprise acceptable adjuvant and compositions provided by the invention in bromatology; Said composition obtains primarily of following raw material: Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives; As preferably, with parts by weight, Fructus Mori 1000 ~ 4000 parts, Fructus Lycii 1000 ~ 4000 parts, Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; Preferably, with parts by weight, Fructus Mori 2000 ~ 4000 parts, Fructus Lycii 2000 ~ 4000 parts, Flos Chrysanthemi 1000 ~ 3000 parts, 1000 ~ 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 1000 parts, 1000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 2000 parts, Fructus Lycii 2000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 5 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 3000 parts, Fructus Lycii 3000 parts, Flos Chrysanthemi 2000 parts, 2000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 10 parts; In embodiments more provided by the invention, with parts by weight, Fructus Mori 4000 parts, Fructus Lycii 4000 parts, Flos Chrysanthemi 3000 parts, 3000 parts, Folium Mori, phylloxanthin and/or xanthophyll derivatives 15 parts; Described in the present composition, xanthophyll derivatives is preferably lutein ester; In embodiments more provided by the invention, said composition also comprises one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii.
As preferably, the dosage form of health food is tablet, capsule, medicinal tea, granule, effervescent tablet, buccal tablet, disintegrating tablet or pill.But the dosage form of health food of the present invention is not defined in this, those skilled in the art think that feasible dosage form is all within protection scope of the present invention, and the present invention is in this no limit.
The invention provides a kind of composition and method of making the same of liver-nourishing and eyesight-improving effect.Said composition obtains primarily of Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori and phylloxanthin and/or xanthophyll derivatives.The present invention at least has one of following advantage:
The present composition, has protective effect to photoinduced retina rod cell, cone cell damage, suppresses photoperiod sensitivity gene and impel it to return to normal level, thus effectively protecting photoinduced retina injury.Remarkable suppression retina Caspase3 expresses, the remarkable generation suppressing MDA in tissue, improve total antioxidant capacity and catalatic vigor, therefore improve Chinchilla Rabbit retina anti-oxidation stress level, the present composition have employed the five tastes prescription of simplifying, by rational formula and consumption proportion, effectively can treat retinal diseases: degeneration of macula, retinitis pigmentosa, the diagram shape malnutrition of Stargardt disease (Stargardt ' sdisease) Progressive cone dystrophy and retinal pigment epithelium, macular edema, detachment of retina, retina wound, Retinal neoplasms and the retinal diseases be associated with described tumor, congenital hypertrophy of retinal pigmented epithelium, acute multifocal ischemic choroidopathy, and acute retinal pigment epithelitis, create the effect of significant alleviating asthenopia,
The present composition has definite liver injury protection effect, reaches the definite curative effect of liver-nourishing and eyesight-improving, to human non-toxic's side effect, is applicable to long-term edible, can plays the beneficial effect for the treatment of and health care two-ways regulation;
Production method of the present invention is simple, remains the nutritional labeling of Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori etc. simultaneously in process of production, is beneficial to absorption of human body.
Accompanying drawing explanation
Fig. 1: tested material is on the impact of Chinchilla Rabbit visual electrophysiology function; Figure 1A: scotopia is reacted, Figure 1B: photopic vision is reacted, and # is P<0.05 compared with blank group; * blank group of P<0.05 compared with model group (lower same);
Fig. 2: tested material is to the protective effect of Chinchilla Rabbit outer nuclear layer thickness; Fig. 2 A: retina HE colored graph; Fig. 2 B: outer nuclear layer thickness;
Fig. 3: the effect that tested material is expressed Chinchilla Rabbit retina Caspase3; Fig. 3 A: retina Caspase3 SABC figure; Fig. 3 B: immunohistochemical staining is marked;
Fig. 4: tested material is to the effect of Chinchilla Rabbit retina oxidative stress level; Fig. 4 A:MDA; Fig. 4 B:T-AOC; Fig. 4 C:CAT.
Detailed description of the invention
The invention discloses a kind of composition and method of making the same of liver-nourishing and eyesight-improving effect, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
In the composition and method of making the same of liver-nourishing and eyesight-improving effect provided by the invention, raw materials used medicine or adjuvant all can be buied by market.
Below in conjunction with embodiment, set forth the present invention further:
The preparation of embodiment 1 compositions
Compositions described in the present embodiment is made up of the component of following weight ratio: Fructus Mori 2g, Fructus Lycii 2g, Flos Chrysanthemi 1g, Folium Mori 1g, phylloxanthin 10mg.
Preparation method is as follows:
Take each raw material components in proportion for subsequent use; By Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing water extraction, extracting solution is concentrated, dry, obtain mixing major ingredient;
Phylloxanthin is added above-mentioned mixing major ingredient, mix homogeneously, be crushed to more than fineness of the particles 100 order, obtain the present composition.
The preparation of embodiment 2 compositions
Compositions described in the present embodiment is made up of the component of following weight ratio: Fructus Mori 2g, Fructus Lycii 2g, Flos Chrysanthemi 3g, Folium Mori 3g, phylloxanthin 5mg.
Preparation method is with embodiment 1.
The preparation of embodiment 3 compositions
Compositions described in the present embodiment is made up of the component of following weight ratio: Fructus Mori 3g, Fructus Lycii 3g, Flos Chrysanthemi 2g, Folium Mori 2g, phylloxanthin 10mg.
Preparation method is as follows:
Choose, take Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori raw material;
Above-mentioned raw materials is cleaned respectively, sterilizes, sterilizing, pulverizing, obtain mixing major ingredient;
Phylloxanthin is added above-mentioned mixing major ingredient, mix homogeneously, be crushed to more than fineness of the particles 100 order, obtain the present composition.
The preparation of embodiment 4 compositions
Compositions described in the present embodiment is made up of the component of following weight ratio: Fructus Mori 4g, Fructus Lycii 4g, Flos Chrysanthemi 3g, Folium Mori 3g, lutein ester 15mg.
Preparation method is as follows:
Take each raw material components in proportion for subsequent use; By Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori mixing water extraction, extracting solution is concentrated, dry, obtain mixing major ingredient;
Lutein ester is added above-mentioned mixing major ingredient, mix homogeneously, be crushed to more than fineness of the particles 100 order, obtain the present composition.
The preparation of embodiment 5 compositions
The compositions of the alleviating asthenopia described in the present embodiment, it is made up of the component of following percentage by weight: Fructus Mori 2g, Fructus Lycii 2g, Flos Chrysanthemi 1g, Folium Mori 1g, phylloxanthin 10mg.
Preparation method is as follows:
(1) each raw material components is taken in proportion for subsequent use;
(2) by Fructus Mori, Fructus Lycii mixing water extraction, 75% alcohol settling, obtains polysaccharide precipitation;
(3) Folium Mori, Flos Chrysanthemi mixing water extraction, extracting solution concentrates, and is mixed by water extract with the polysaccharide precipitation in step (2), dry, obtains mixing major ingredient;
(4) phylloxanthin is added the mixing major ingredient in step (3), mix homogeneously; Be crushed to more than fineness of the particles 100 order, obtain the present composition.
Embodiment 6 compositions is for the protective effect of retina injury
1, laboratory sample and method
1.1 laboratory samples and reagent
Getting above-described embodiment 1 resulting composition is given the test agent.Experiment reagent is compound tropicamide eye drops, Chloramphenicol Eye Drop, Su Mian Xin II injection (xylazine hydrochloride injection), conductive paste, Caspase-3 antibody (ab2171), malonaldehyde (MDA) measure test kit, catalase (CAT) measures test kit, total antioxidant capacity (T-AOC) detection kit, BCA determination of protein concentration test kit.
1.2 experimental subject
30 regular grade Chinchilla Rabbit, male and female are not limit, body weight 2.5 ± 0.2kg.All laboratory animals are examination of ocular fundus after experiment moves ahead examination with slitlamp microscope and mydriasis all, and deutomerite is showed no exception at the moment.Cleaning grade Chinchilla Rabbit is raised in indoor, and ventilation condition is good, and normal day-night change (8:00am-8:00pm), relative humidity is 55 ± 5%, and room temperature is 23 ± 2 DEG C.To feed administration 21 days, within the 14th day, carry out photic damage irradiation.
1.3 experimental technique
1.3.1 animal grouping and administration
Raised one week by Chinchilla Rabbit adaptability, period freely adopts water, diet.Be divided into 5 groups at random by body weight after 1 week, be respectively blank group, model group, the low middle high dose group of given the test agent.The calculating of gavage amount calculates according to the method for Xu Shuyun etc., namely calculate according to the dose,equivalent ratio of the body surface area conversion of people and rabbit, low-dosage sample consumption every day (g)=1.36 × 0.07 × [rabbit weight (kg)/1.5], middle dosage is its 3 times, high dose is 3 times of middle dosage, every day gavage 1 time.Gavage method: sample normal saline makes suspension, translucent silicone catheter, gag carries out gavage, uses rabbit to press from both sides and be fixed in gavage process.
1.3.2 photic damage is irradiated
Model group and low middle high dose group Chinchilla Rabbit are after dark adaptation 24h, compound tropicamide eye drops carries out mydriasis to eyes, 20min is placed in self-control lighting box and starts illumination, a Chinchilla Rabbit is placed in each lighting box, illuminance is 18000 ± 1000lux, and illumination 2h does not limit Chinchilla Rabbit activity, whole During Illumination keeps ventilating, and makes the temperature in lighting box remain on 21-24 DEG C.Illumination terminates rear experimental animal and sends dark adaptation in Animal House back to, and each group experimental animal carries out electroretinogram mensuration respectively at first day before illumination, after illumination and the 7th day, and whole process of the test freely adopts water, diet.
1.3.3ERG measure
Scalpel scrapes off chaeta among a small circle in Chinchilla Rabbit forehead and temporo side, exposes epidermis, is convenient to the stickup of electrode.Su Mian Xin intramuscular anesthesia experimental animal before detecting, the abundant mydriasis of compound tropicamide eye drops.In dark situation, ERG electrode is placed down after dark adaptation 30min, front pole electrode conductance patch is in forehead, ground electrode is connected in homonymy temporo side, gold hook electrode is hung on lower eyelid and contacts with cornea, regulate and stimulate light and intensity, carry out the mensuration of scotopia retinal rod reaction with reference to clinical ERG standard (1990).After scotopia reaction assay, light adaptation 30min, carries out photopic vision cone reaction assay.Mensuration terminates rear lucifuge and sends experimental animal back to Animal House dark adaptation, normally adopts water and feed, and carries out the demarcation of b wave-wave width to measuring the ERG figure obtained, and record data, analyze.
1.3.4 retinal histology is observed
After illumination 7d carries out ERG mensuration, Chinchilla Rabbit is put to death by air tap inserting method, extracts eyeball, puts into 4% formalin immediately, fix 24h at 4 DEG C.Remove cornea and crystal after 24h, again fix 24 hours.Along optic nerve vertical meridian, shear and obtain retina longitudinal section, buffer solution for cleaning, dehydration of alcohol step by step, routine paraffin wax embeds, ultrathin section, and HE dyes, and inverted microscope is observed, and takes the photograph sheet, adopts image processing software to process.On picture, nipple is looked in location, along looking nipple up and down every 500 μm, getting and a little carrying out outer nuclear layer (ONL) thickness measurement, get 12 points altogether, record data, statistical analysis.
1.3.5 SABC detects
(1) section dewaxing: environment friendly transparent agent is immersed in section, changes 5 times, each 5min; (2) decylization of cutting into slices protects clarifier: dehydrated alcohol is immersed in section and changes 2 times, each 2min; (3) section dealcoholization: section is immersed 95% respectively, 80% ethanol, each 2min, tap water, then immerse deionized water 1 minute; (4) increase the upper cell permeability of section: 0.1MpH6.0 citric acid soln is immersed in section, hot high pressure repair 3 points 30 seconds, natural cooling, immersion deionized water, washes 3 times, each 1 minute; (5) close: close 20min by 3% aqueous hydrogen peroxide solution room temperature, deionized water is immersed in section, 3 times, each 2min, shirt import normal sheep serum working solution during section is immersed, room temperature closes 30min, and PBS is immersed in section, 3 times, PBS rinses 2 times, each 2min; (6) primary antibodie is hatched: by the dilution of Caspase3 monoclonal antibody 10% sheep blood serum 50 times, 4 spend night; (7) labeled reactant: room temperature rewarming more than 1 hour, tapping microscope slide removes a resistant to liquids, and PBST rinses 3 times, and each 2min, PBS rinse 2 times, each 2min; Add the reagent 1, room temperature 25min in the PV-9002 against murine immunohistochemical kit of Zhong Shan company; PBST rinses 3 times, and each 2min, PBS rinse 2 times, each 2min; Add the reagent 2, room temperature 30min in the PV-9002 against murine immunohistochemical kit of Zhong Shan company; PBST rinses 3 times, and each 2min, PBS rinse 2 times, each 2min; (8) DAB colour developing: tapping microscope slide removes surplus liquid, adds the nitrite ion of 50ulDAB (5ul adds 1ml buffer) 20 times dilution, basis of microscopic observation.Deionized water cessation reaction; (9) redye, mounting: haematoxylin redyeing 4 minutes, with the hydrochloride alcohol pink colour liquid color separation of new preparation, conventional method oil blackeite, dehydration, mounting.
1.3.6 in retinal tissue, malonaldehyde, total antioxidant capacity and catalase detect
(1) retinal tissue homogenate preparation: take out the retinal tissue be kept in-80 DEG C of refrigerators, the weight of analytical balance precise specimen to be measured, volume ratio 1:9 normal saline on the rocks by weight, grinds to form tissue homogenate with grinding rod by retinal tissue in EP pipe under ice-water bath.-4 DEG C, 2500 revs/min low-temperature and high-speed centrifuge 15 minutes, get supernatant for subsequent use.
(2) malonaldehyde (MDA), catalase (CAT) and total antioxidant capacity (T-AOC) detect: malonaldehyde, catalase, total antioxidant capacity and determination of protein concentration detect the explanation of reference reagent box and detect.
2, experimental result
2.1 impacts on Chinchilla Rabbit visual electrophysiology function
2.1.1 on the impact of Chinchilla Rabbit ERG scotopia reaction
After illumination, secretly suitable ERG and blank group all have significant difference (as Figure 1A) for first day and the 7th day model group, ERG scotopia response value reflection rod cell function status, illustrate that 18000lux illumination in 2 hours causes damage to Chinchilla Rabbit rod cell, wherein after illumination, first day and the 7th day dark suitable b wave-amplitude not have dropped 32.43% and 27.68% relative to blank elements.After illumination, first day all has significant difference with high dose group in the 7th day tested material compared with model group; 57.33% and 41.33% is improve respectively relative to first day b wave-amplitude after high dose group illumination in model group; within 7th day, b wave-amplitude improves 41.98% and 29.63% respectively, illustrates that given the test agent has protective effect to photoinduced retina rod cell damage.
2.1.2 on the impact of Chinchilla Rabbit ERG photopic vision reaction
After illumination, the 7th day bright suitable ERG of model group and blank group have significant difference (as Figure 1B), the change of what photopic vision ERG mainly reflected is cone cell, illustrate that 18000lux illumination in 2 hours causes damage to Chinchilla Rabbit cone cell, wherein after illumination, the 7th daybreak is fitted b wave-amplitude and be have dropped 25.49% relative to blank group.After illumination, the 7th day administration group compares model group all remarkable increase; wherein middle high dose group does not improve 28.95% and 29.26% relative to model components; there is significant difference, illustrate that tested material has protective effect to photoinduced retinal cones cell injury.
The protective effect of 2.2 pairs of Chinchilla Rabbit outer nuclear layer thickness
After illumination 7 days, blank group retinal tissue form was normal, and layer of structure is clear, interior acromere marshalling rule, and photoperiod sensitivity gene a large amount of in model group, quantity significantly reduce, outer core cellular layer is thinning, and the above-mentioned phenomenon of middle high dose group significantly improves (as Fig. 2 A); Photic damage model group significantly reduces by 27.14% (p<0.05) relative to blank group ONL layer thickness, the Chinchilla Rabbit retina ONL layer thickness of middle high dose group raises 25.78% and 28.21% (p<0.05) (as Fig. 2 B) respectively compared with model group, is conducive to the recovery of photoreceptor cell，photosensory cell number.
The effect that 2.3 couples of Chinchilla Rabbit retina Caspase3 express
In this experiment, Caspase3 mainly dye (as Fig. 3 A) at amphiblestroid inner nuclear layer and ganglion cell layer, and immunohistochemical staining standards of grading are according to the ratio of positive cell and staining power scoring.Model group retina Caspase3 expresses 2.8 times (p<0.05) being about blank group, middle high dose health product significantly suppress retina Caspase3 to express (p<0.05), are respectively 15.92% and 10.64% of model group expression.
The effect of 2.4 pairs of Chinchilla Rabbit retina oxidative stress levels
Compared with blank group, after photic damage, in model group retinal tissue, MDA content significantly raises (p<0.05), in middle high dose group retina, MDA level reduces 39.02% and 54.08% respectively relative to model group, all has significant difference (p<0.05) (as Fig. 4 A); In model group retinal tissue, total antioxidant capacity significantly reduces (p<0.05), in middle high dose group retina, total antioxidant capacity raises 2.97 and 3.10 times respectively relative to model group, all has significant difference (p<0.05) (as Fig. 4 B); In model group retinal tissue, CAT vigor significantly reduces (p<0.05), in middle high dose group retina, CAT level raises 2.97 and 3.40 times respectively relative to model group, all has significant difference (p<0.05) (as Fig. 4 C).
As can be seen from Fig. 1-Fig. 4 result; the present composition is used to intervene; there is protective effect to photoinduced retina rod cell, cone cell damage, suppress photoperiod sensitivity gene and impel it to return to normal level, thus effectively protecting photoinduced retina injury.Remarkable suppression retina Caspase3 expresses, the remarkable generation suppressing MDA in tissue, improve total antioxidant capacity and catalatic vigor, therefore improve Chinchilla Rabbit retina anti-oxidation stress level, the present composition have employed the five tastes prescription of simplifying, by rational formula and consumption proportion, effectively can treat retinal diseases, degeneration of macula, retinitis pigmentosa, the diagram shape malnutrition of Stargardt disease (Stargardt ' sdisease) Progressive cone dystrophy and retinal pigment epithelium, macular edema, detachment of retina, retina wound, Retinal neoplasms and the retinal diseases be associated with described tumor, congenital hypertrophy of retinal pigmented epithelium, acute multifocal ischemic choroidopathy, and acute retinal pigment epithelitis, create the effect of significant alleviating asthenopia.
The compositions that Example 2 ~ 5 is obtained, according to above-mentioned test method, carry out the mensuration of the reaction of scotopia retinal rod and the reaction of the photopic vision cone, carry out retinal histology to observe and SABC detection, detect malonaldehyde in retinal tissue, total antioxidant capacity and catalase, effect of its result of the test and embodiment 1 compositions is close, show that embodiment 2 ~ 5 compositions is to photoinduced retina rod cell, cone cell damage has protective effect, suppress photoperiod sensitivity gene and impel it to return to normal level, thus effectively protect photoinduced retina injury, remarkable suppression retina Caspase3 expresses, and significantly suppresses the generation of MDA in tissue, improves total antioxidant capacity and catalatic vigor, therefore improves Chinchilla Rabbit retina anti-oxidation stress level, create the effect of significant alleviating asthenopia.
Embodiment 7 treats the test of rat light type alcoholic hepatic injury
Getting above-described embodiment 1-5 resulting composition is experiment product, by the product A in contrast of compositions disclosed in embodiment 1 in publication number CN102919921A, by compositions disclosed in specific implementation method (each amounts of components gets intermediate value) product B in contrast in publication number CN102366009A, by disclosed for embodiment in publication number CN102204615A 1 concrete compositions product C in contrast, according to the preparation method preparation experiment product be pulverized and mixed in the embodiment of the present invention 3 and reference substance.
Rat normally raises 2d, be divided into Normal group, ethanol model group (56 ° of Chinese liquor of 1: 1 dilution), bifendate positive controls (100mg/kg), embodiment 1-5 (4.0g crude drug/kg), control group A-C (4.0g crude drug/kg) at random, often organize 12.Bifendate positive controls: 56 ° of Chinese liquor that ig bifendate+14ml/kg1: 1 dilutes, each administration group is all with 56 ° of Chinese liquor that 1.0ml/100g (body weight) gavage embodiment 1-5 (or control group A-C)+14ml/kg1: 1 dilutes, Normal group gavage gives isometric(al) distilled water, 56 ° of Chinese liquor of ethanol model group ig distilled water+14ml/kg1: 1 dilution, altogether 10d.Last gives fasting 24h after drinking, and eye socket gets blood, separation of serum.ALT, AST is measured, the results detailed in Table 1 with ALT/AST testing cassete.Then cervical dislocation puts to death rat, and broken abdomen gets liver immediately, clean with normal saline flushing, gets liver lobus sinister same area, fixes, paraffin embedding with 10% formalin solution, and HE dyes, and makes pathologic finding.
Table 1 is on the impact of the alcohol induced Liver Damage in Rats serum transaminase of rat 56%
| Group | Animal number of elements | Dosage (g crude drug/kg) | ALT(U/L) | AST(U/L) |
| Blank group | 12 | - | 46.2 | 175.9 |
| Model control group | 12 | - | 72.6 | 247.2 |
| Embodiment 1 | 12 | 4.0 | 50.1 | 181.5 |
| Embodiment 2 | 12 | 4.0 | 45.4 | 174.8 |
| Embodiment 3 | 12 | 4.0 | 43.9 | 171.9 |
| Embodiment 4 | 12 | 4.0 | 44.7 | 188.6 |
| Embodiment 5 | 12 | 4.0 | 49.2 | 179.4 |
| Bifendate group | 12 | 100mg/kg | 41.9 | 173.5 |
| Reference substance A | 12 | 4.0 | 81.8 | 213.7 |
| Reference substance B | 12 | 4.0 | 97.9 | 228.8 |
| Reference substance C | 12 | 4.0 | 104.6 | 219.2 |
More than test shows; the present composition all has definite liver injury protection effect; by prescription and the reasonable compatibility of selected integration of edible and medicinal herbs; reach and be beneficial to absorption significantly; the definite curative effect of liver-nourishing and eyesight-improving; to human non-toxic's side effect, be applicable to long-term edible, the beneficial effect for the treatment of and health care two-ways regulation can be played.The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. a compositions, is characterized in that, obtains primarily of following raw material:
Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori, phylloxanthin and/or xanthophyll derivatives.
2. compositions according to claim 1, is characterized in that, with parts by weight, described Fructus Mori 1000 ~ 4000 parts, described Fructus Lycii 1000 ~ 4000 parts, described Flos Chrysanthemi 500 ~ 3000 parts, 500 ~ 3000 parts, described Folium Mori, described phylloxanthin and/or xanthophyll derivatives 5 ~ 15 parts.
3. compositions according to claim 1 and 2, is characterized in that, also comprises one or more in Flos Lonicerae, Semen Cassiae, Fructus Crataegi or Bulbus Lilii.
4. compositions according to any one of claim 1 to 3, wherein said xanthophyll derivatives is lutein ester.
5. compositions according to any one of claim 1 to 4 is being prepared inhibited oxidation stress, is being prevented and treated retina injury or alleviating asthenopia, the application in the control medicine of hepatic injury or health food.
6. the preparation method of compositions according to any one of Claims 1-4, is characterized in that, adopt following a)-c) in the preparation of one or more methods, comprise the steps:
A) Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori are pulverized, obtain mixing major ingredient; Phylloxanthin and/or xanthophyll derivatives are mixed with the described major ingredient that mixes, obtains compositions; Or
B) by Fructus Mori, Fructus Lycii, Flos Chrysanthemi, Folium Mori water extraction, concentrated, dry, obtain mixing major ingredient; Phylloxanthin and/or xanthophyll derivatives are mixed with the described major ingredient that mixes, obtains compositions; Or
C) by Fructus Mori and Fructus Lycii Fructus Lycii mixing water extraction, alcohol settling, obtains polysaccharide precipitation;
By Folium Mori and Flos Chrysanthemi mixing water extraction, obtain water extract;
Described water extract is mixed with described polysaccharide precipitation, dry, obtain mixing major ingredient;
Phylloxanthin is mixed with the described major ingredient that mixes, obtains compositions.
7. the preparation method of compositions according to claim 6, wherein said xanthophyll derivatives is lutein ester.
8. a product, described product is medicine or health food, it is characterized in that, comprises adjuvant and compositions according to any one of Claims 1-4, and described adjuvant is acceptable adjuvant in pharmaceutically acceptable adjuvant or bromatology.
9. product according to claim 8, is characterized in that, the dosage form of described medicine is tablet, capsule, medicinal tea, granule, effervescent tablet, buccal tablet, disintegrating tablet or pill.
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| CN105434678A (en) * | 2015-12-16 | 2016-03-30 | 成都市康飞药业有限公司 | Composition for preventing and/or treating sub-health caused by using of electronic products |
| CN106418529A (en) * | 2016-08-02 | 2017-02-22 | 马佳 | Preparation method of chrysanthemum oral liquid capable of improving immunity and oral liquid thereof |
| CN106539083A (en) * | 2016-10-28 | 2017-03-29 | 河南省科高植物天然产物开发工程技术有限公司 | It is a kind of to be used to prevent and treat diabetic retinopathy, alleviate asthenopic compositionss |
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| CN105434678A (en) * | 2015-12-16 | 2016-03-30 | 成都市康飞药业有限公司 | Composition for preventing and/or treating sub-health caused by using of electronic products |
| CN106418529A (en) * | 2016-08-02 | 2017-02-22 | 马佳 | Preparation method of chrysanthemum oral liquid capable of improving immunity and oral liquid thereof |
| CN107811168A (en) * | 2016-09-14 | 2018-03-20 | 北京宝得瑞健康产业有限公司 | A kind of eye-protecting function beverage and preparation method thereof |
| CN106539083A (en) * | 2016-10-28 | 2017-03-29 | 河南省科高植物天然产物开发工程技术有限公司 | It is a kind of to be used to prevent and treat diabetic retinopathy, alleviate asthenopic compositionss |
| CN106539083B (en) * | 2016-10-28 | 2020-01-17 | 河南省科高植物天然产物开发工程技术有限公司 | A composition for preventing and treating diabetic retinopathy and relieving asthenopia |
| CN106880626A (en) * | 2017-03-14 | 2017-06-23 | 何伟 | Application of the Kaempferol in prevention and treatment retinal damage disease medicament is prepared |
| CN107753739A (en) * | 2017-10-24 | 2018-03-06 | 宁国平衡健康管理有限公司 | A kind of liver protection alternative tea and preparation method thereof |
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| CN115918828A (en) * | 2022-12-23 | 2023-04-07 | 安徽九鑫药业有限公司 | Honeysuckle, mulberry leaf and mulberry instant drink |
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Application publication date: 20151209 |