CN103622994A - Compound ointment containing borneol, sulfur and realgar - Google Patents
Compound ointment containing borneol, sulfur and realgar Download PDFInfo
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- CN103622994A CN103622994A CN201210309133.8A CN201210309133A CN103622994A CN 103622994 A CN103622994 A CN 103622994A CN 201210309133 A CN201210309133 A CN 201210309133A CN 103622994 A CN103622994 A CN 103622994A
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Abstract
A compound ointment containing borneol, sulfur and realgar is a dermatologic externally-used drug mainly used for treating herpes zoster and developed against the tedious method, slow curative effect, high cost and obvious side effects of the long-term Chinese and Western medicinal herpes zoster treatment. The compound ointment is obtained by mincing borneol (3-5g), sulfur (3-5g), realgar (1-2g), dexamethasone (0.75mg*10 tablets) and furazolidone (0.1mg*5 tablets), mixing, adding a proper amount of Vaseline, and blending. The compound ointment is applied onto affected parts to treat diseases comprising the herpes zoster, dermatitis, eczemas, scabies, acnes, mumps, acne rosacea and psoriasis.
Description
One, title: compound recipe ice two unguentum flavums
Two, technical field: the department of dermatologry medicine for external use class in medical science field.
Three, technical background: herpes zoster is viral dermatosis, in doctor trained in Western medicine, range < < skin cypridology > >, the traditional Chinese medical science is named as herpes zoster, have another name called herpes zoster, herpes zoster, herpes zoster, herpes zoster etc., range < < Surgery of Chinese Medicine > >.
(1) in doctor trained in Western medicine < < skin cypridology > >, the treatment of herpes zoster is expressed as:
Primary disease has self limiting, and Therapeutic Principle is antiviral, pain relieving, antiinflammatory, prevents and treats complication.
1. innerlich anwenden thing treatment:
(1) antiviral drugs: early stage, enough antiviral therapies, particularly 50 years old above patient, is conducive to alleviating neuropathic pain, shortens the course of disease.Conventionally after dermexanthesis, in 48-72 hour, start antiviral therapy.The each 800mg of acyclovir, every day 5 times is oral; Or the each 1000mg of valaciclovir, every day 3 times is oral; Or the each 250mg of famciclovir, every day 3 times is oral.Be 7 days the course for the treatment of.
(2) pain relieving: can take the circumstances into consideration to select somedon sheet, indomethacin etc.Medicine that simultaneously can applied nutrition nerve, as oral or intramuscular injection vitamin B1, B12.
(3) glucocorticoid: apply disputablely, think that early rationally application can inflammation-inhibiting process more, shorten the course of disease of acute stage herpes dependency pain, but to PHN (post-herpetic neuralgia) without sure preventive effect.Be mainly used in the course of disease 7 days with interior, without the gerontal patient of other relevant diseases, can oral prednisone 30-40mg/d.The course for the treatment of 7-10 days.
2. external medication:
(1) medicine for external use: take be dried, antiinflammatory is as main.Can external Calamine Lotion when bleb liquid is broken, Virless Cream or Denavir; Can be as one sees fit with 3% boric acid solution or furacilin solution soak in 1: 5000 after herpes ulceration, or external 0.5% neomycin ointment or mupirocin ointment.
(2) eye is processed: as merged eye infringement, need to ask ophthalmologist's associated treatment.Can external 3% aciclovir eye ointment, idoxuridine (iodouracil desoxyriboside) eye drop, local forbidding glucocorticoid external preparation.
3. naturopathy is as local irradiations such as ultraviolet, frequency spectrograph, infrared ray, can alleviating pain, promote the dry and incrustation of vesicle.”
---select from national Teaching Materials at College level < < skin cypridology > > the 7th edition.
As can be seen here, its internal treatment is very loaded down with trivial details, by prodrug complex and slow curative effect, expensive and side effect is obvious.Cost and result that whole body drug treatment local patholoic change that Here it is is born.Its external treatment and naturopathy are auxiliary treatment, and what play is symptomatic treatment effect.Its Main Function be dried, antiinflammatory, alleviating pain, promote the dry and incrustation of vesicle.
Take a broad view of above-mentioned Therapeutic Method: curative effect is slow, the course of disease is long, generally in 2-3 week, old people is 3-4 week.
(2) in < < Surgery of Chinese Medicine > >, the Therapeutic Method of herpes zoster (herpes zoster that is equivalent to doctor trained in Western medicine) is expressed as:
It is main method for the treatment of that clearing away heat-damp and promoting diuresis, promoting the circulation of QI to relieve pain are take in primary disease treatment.Initial stage be take clearing away heat-damp and promoting diuresis as main; Later stage be take promoting blood circulation, dredging meridian and relieving pain as main; Body void person, with strengthening vital QI to eliminate pathogenic factors and removing obstruction in the collateral to relieve pain use.
1. determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs:
(1) 1. stagnated heat of liver channel card syndrome for the treatment of by oral administration of medicines: skin lesion is scarlet, scorching hot twinge, tonic vesicle wall; Bitter taste in the mouth and dry throat, susceptible to lose temper due to restlessness, is hard and dry or yellow urine; Red tongue, yellow and thin fur or yellow thick, stringy and rolling pulse number.Method for the treatment of: let out clearly liver-fire, removing toxic substances pain relieving.Side's medicine: Longdanxiegan Tonga Radix Arnebiae (Radix Lithospermi), Radix Isatidis, corydalis tuber etc.Send out in women's head-ornaments person, add Fructus Arctii, Flos Chrysanthemi Indici; The person that has blood blister, adds Cornu Bubali powder, Cortex Moutan; The obvious person of pain, adds Olibanum (processed), Myrrha (processed).2. insufficiency of the spleen wetting accumulate card syndrome: skin lesion color is light, and pain is aobvious, flaccid vesicle wall; Mouth is not thirsty, and lack of appetite abdominal distention is half congealed during stool; Light red tongue or normal, Tai Bai or greasy in vain, deep-slow pulse or cunning.Method for the treatment of: invigorating spleen to remove dampness, removing toxic substances pain relieving.Side's medicine: dehumidifying Wei Ling Tonga subtracts.Send out in lower limb person, add Radix Achyranthis Bidentatae, Cortex Phellodendri; Large and the many person of vesicle, adds Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Herba Plantaginis.3. syndrome of qi stagnation and blood stasis syndrome: erythra alleviate or disappear after local pain more than, emit near position, unbearably painful, uneasy in either sitting or lying, sustainable several months of severe one or longer time; Tongue is dim, and tongue is white, stringy and thready pulse.Method for the treatment of: vital energy regualting and blood circulation-promoting, removing obstruction in the collateral to relieve pain.Side's medicine: bupleurum powder for relieving liver-qi closes ingredient-modified Taohong Siwu decoction.Vexed insomniac, adds Concha Margaritifera, Concha Ostreae, SHANZHIZI, Semen Ziziphi Spinosae; Person with intense pain, adds corydalis tuber, Olibanum (processed), Myrrha (processed), Scolopendra etc.
(2) 1. external treatment is just reinstated two taste Herba Sidae Szechuensiss and is adjusted strong tea water to be coated with outward; Or external application YULU cream; Or outer putting on the skin Shuang Bai San, SANHUANG lotion, cooling emulsions (Oleum Sesami adds saturated limewater supernatant and fully stirs into emulsus), every day three times; Or fresh Dens Equi flower, wild chrysanthemum leaf, Flos Hostae Plantagineae floral leaf is mashed external application.If after 2. vesicle is broken, be coated with outward with Rhizoma Coptidis extractum, four yellow cream or Indigo Naturalis pipe, there is bad the dead, with nine-Dan or tidal land, fall apart and change dressings.If 3. vesicle is not broken or vesicle the greater, available three edged needle or sterilization empty needle puncture, and exhaust bleb liquid or bleb liquid stream is gone out, to alleviate distending pain sense of discomfort.
2. other therapies:
(1) 1. antiviral drugs of western medical treatment: should apply early acyclovir 5mg/kg intravenous drip, every 8 hours 1 time, 5-7 day is 1 course for the treatment of.In addition available vidarabine 15mg/ (kgd) still, 1 times/day, slowly quiet more than 12 hours; Also can oral acyclovir, each 0.2g, 5 times/day; Or famciclovir, each 0.25g, 3 times/day; Or valaciclovir, each 0.3g, 2 times/day.Be 7-10 day the course for the treatment of.2. glucocorticoid: early application can ease the pain, preferably application in onset 5-7 day.General application prednisone 20-30mg/d, minute 2-3 time oral, is used in conjunction 3-7 day.3. analgesic drug product: optional somedon, ibuprofen, indomethacin, diclofenac, Dai Fen etc.Also can select aspirin.
(2) pass, gb 34, tsu san li in acupuncture acupoint selection.The flat thorn of local sleeping pin around, let the acupuncture needle remain at a certain point 30 minutes, every day 1 time.Pain with the passing of time person adds Zhigou, or jar acupuncture hepatic region, imbedding needle 3 days.Or Ashi point strong stimulation.”
---select from new century second edition whole nation higher institutions of Chinese medicine planning teaching material < < Surgery of Chinese Medicine > >.
In view of this, in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the medicine typing of its treatment by oral administration of medicines, principle-method-recipe-medicines, plus-minus changes very complicated, and non-veteran senior full-time Chinese physician can not accurate dialectical medication, and curative effect is slow, the course for the treatment of is long, from seeing a doctor the decoction of making up the prescription etc., all has numerous and diverse and factor that affect the treatment, is difficult to become first-selection.In its external treatment, provide the square medicine of selection more, all non-finished medicines, purchases medicine, preparation, use etc. all extremely inconvenient, and curative effect slowly and not certainly.The innerlich anwenden thing treatment of its western medical treatment and front < < skin cypridology > > is basic identical, and disadvantage the more.Its acupuncture treatment, the one, amateur acupuncture therapy Shi Buneng implements; The 2nd, patient is painful; The 3rd, belong to auxiliary treatment, pain relieving can, antiinflammatory, antiviral are still uncertainly.
Take a broad view of above-mentioned Therapeutic Method: the course of disease about 2 weeks, in about 3-4 week of old people, treatment is complicated, the course for the treatment of is long and curative effect is real difficult satisfied.
The cause and onset of disease mechanism of herpes zoster:
VZV (varicella zoster virus) is called after human herpesvirus 3 type (HHV-3) now.Virus is brick shape, has three-dimensional symmetrical capsid, includes double chain DNA molecule, only has One serotype.VZV to the resistance of external environment a little less than, in dry crust, lose activity very soon.
People is unique host of VZV.Virus enters blood through respiratory mucosa and forms viremia, chickenpox occurs or be inapparent infection, and rear virus lays dormant is in spinal cord posterior root ganglion or cranial nerve sensory ganglion; While stimulating (as wound, fatigue, malignant tumor or weak etc. after being ill) to cause Abwehrkraft des Koepers to decline when body is subject to certain, latent virus is activated, descending along sensory nerve axon, arrive in the skin in region that this nerve is arranged and copy, produce vesicle, get involved nerve is inflamed, necrosis simultaneously, produces neuralgia.Originally after recovering, can obtain more lasting immunity, therefore generally can not send out again.
---select from national Teaching Materials at College level < < skin cypridology > > the 7th edition.
The sick position that can be shown herpes zoster by above-mentioned cause and onset of disease mechanism produces sings and symptoms on the skin in body surface nerve and domination region thereof.Because sick position is at epidermis, thus completely can be according to other treating for skin disease general character, and the external treatment of take is treated as main.
Four, summary of the invention:
The technical problem that 1, will solve: for the background technology of above-mentioned herpes zoster, herpes zoster is still dermatosis, all exists dermatosis to take external treatment as main precondition.At present, by external treatment, treat dermopathic new drug develop rapidly, make rapid progress both at home and abroad, but as far as I know, with the medicine for external use of external treatment treatment herpes zoster, be still a blank at present.In order to realize, take medicine for external use as curing mainly the more object of herpes zoster, I have developed " compound recipe ice two unguentum flavums " in 1988, take to be coated with to put affected part on the skin and treat herpes zoster as main mode, and by two hundreds of repetition test and checkings during the last ten years, proof " compound recipe ice two unguentum flavums " in the upper curative effect for the treatment of " herpes zoster " certainly, produce effects very prompt, facilitate inexpensive, economical and practical, side effect is little, particularly the course of disease is short, generally at 3-5 Ke More, severe patient all do not surpass one week Er More." compound recipe ice two unguentum flavums,, filled up the blank that herpes zoster only can be healed by external treatment, started and only with external treatment, can treat the beginning of herpes zoster.It is medicine the most desirable in current herpes zoster, the most effective, most convenient.Meanwhile, through checking repeatedly, " compound recipe ice two unguentum flavums " are equally very effective to multiple dermatosis such as dermatitis, eczema, scabies, acne, parotitis, rosacea, psoriasiss.
2, technical scheme: " compound recipe ice two unguentum flavums " are to grind mixing into powder by Borneolum Syntheticum (3-5g), sulfur (3-5g), Realgar (1-2g) three taste Chinese medicines and dexamethasone (0.75mg * 10 slice), two kinds of Western medicine of furazolidone (0.1mg * 5 slice), calls in that in appropriate vaseline, to make ointment standby.
The pharmacological action analysis of each component medicine:
Borneolum Syntheticum has the merit of the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, has the effect of calmness, analgesia, antibacterial, antiinflammatory, more has and extensively makes an addition in various external preparation to promote the use of the Transdermal absorption of other medicine.
Sulfur has the effect of softening epidermis, acaricide worm, cathartic, relieving cough and expelling phlegm.Clinical external all has clear and definite therapeutical effect to scabies, acne, dermatitis, eczema, dense herpes, rosacea, psoriasis.
That Realgar has is antibacterial, suppress the effects such as dermatophytes, schistosomicide, disease-resistant protozoon, antitumor.Clinical external plays effective therapeutical effect to facial paralysis, various inflammation, urinary tract infection, cervical erosion, parotitis, eczema, scabies, dermatitis, malnutrition due to parasitic infestation, bulbar conjunctiva polyp etc.
Dexamethasone has obvious antiinflammatory action, and histiocyte is had to obvious protective effect, can obviously suppress and shorten inflammatory process, can shorten the course of disease of acute stage herpes dependency pain.
Furazolidone both can affine peripheral nervous, was conducive to effective absorption of Borneolum Syntheticum, sulfur, Realgar, had again the antibacterial carbohydrate metabolism of interference and oxidase system and brought into play local antibacterial effect.
In a word, outside patent of the present invention " compound recipe ice two unguentum flavums " decapacitation specific treatment herpes zoster,
Can also effectively treat dermatitis, eczema, scabies, acne, parotitis, rosacea, impetigo, psoriasis etc.
Using method: the dermatosis patient that herpes zoster and attending effectiveness are conformed to carries out after routine disinfection with hydrogen peroxide or ethanol, " compound recipe ice two unguentum flavums " that prepared are coated with and are put on the skin in affected part, widen the trouble face that has more as far as possible, then repaste the place of putting on the skin and gently rub 1-2 minute, to promote ointment more to absorb.
Five, the specific embodiment: 1, Borneolum Syntheticum (3-5g), sulfur (3-5g), Realgar (1-2g) three taste Chinese medicines and dexamethasone (0.75mg * 10 slice), two kinds of Western medicine of furazolidone (0.1mg * 5 slice) are ground altogether for smalls, call in appropriate vaseline that to make " compound recipe ice two unguentum flavums " standby.
Generally be diagnosed as the dermatosiss such as herpes zoster, dermatitis, eczema, scabies, acne, parotitis, rosacea, psoriasis and all can select this Ointment in Treatment, bring into play its significant therapeutic effect.
Test case first: Zhao, male ，78Sui， Shaba District, Chongqing City people from village, because suffering from, chronic bronchitis is scorching, emphysema, acute attack is in hospital in Chongqing City hospital of Jiangling factory, during Complicated with Herpes Zoster cause back large area collection bunch property vesicle on back porch neck, hurt like hell.Hospital is diagnosed as Complicated with Herpes Zoster, and through medical treatment three days, effect was also not obvious, and rope medicine is in me upon somebody's introduction, because area is larger, convert " compound recipe ice two unguentum flavums " two parts, be coated with and put affected part on the skin, sooner or later respectively once, pain relief on the 1st, the incrustation that disappears of 2-3 day skin ulcer, recovers on the 5th.After half a year, follow up a case by regular visits to, without staying sequela.
Claims (5)
1. main component, manufacture method and the clinical application of " compound recipe ice two unguentum flavums ".Its principal character is: take Borneolum Syntheticum (3-5g), sulfur (3-5g), Realgar (1-2g) three taste Chinese medicines and dexamethasone (0.75mg * 10 slice), furazolidone (0.1mg * 5 slice) two taste Western medicine is main component, ground into powder mixing, be aided with appropriate vaseline mediation and form; The mode of putting affected part on the skin to be coated with is clinically treated the diseases such as herpes zoster, dermatitis, eczema, scabies, acne, parotitis, acne rosacea, psoriasis.
2. the main component of " compound recipe ice two unguentum flavums " according to claim 1, its principal character is: take Borneolum Syntheticum (3-5g), sulfur (3-5g), Realgar (1-2g) three taste Chinese medicines and dexamethasone (0.75mg * 10 slice), furazolidone (0.1mg * 5 slice) two taste Western medicine is main component.And request retains any component percentage ratio or component dosage and the right to the change of component flavour of a drug plus-minus identical with " compound recipe ice two unguentum flavums " main component.
3. the manufacture method of the main component of " compound recipe ice two unguentum flavums " according to claim 1, it is characterized in that: take Borneolum Syntheticum (3-5g), sulfur (3-5g), Realgar (1-2g) three taste Chinese medicines and dexamethasone (0.75mg * 10 slice), furazolidone (0.1mg * 5 slice) two taste Western medicine is main component, is ground into powder mixing.And request retain and to come from " compound recipe ice two unguentum flavums,, the utilization science and technology refinement mode that main component is identical and right that the dosage form that forms changes.
4. the adjuvant of " compound recipe ice two unguentum flavums " according to claim 1 is selected, and its principal character is: with vaseline, be in harmonious proportion.And request retain with " compound recipe ice two unguentum flavums,, the right that main component adjuvant identical and that occur changes.
5. the clinical application of " compound recipe ice two unguentum flavums " according to claim 1, its principal character is: the mode of putting affected part to be coated with on the skin is treated the diseases such as herpes zoster, dermatitis, eczema, scabies, acne, parotitis, acne rosacea, psoriasis.And request retains the right of the expansion that comes from " compound recipe ice two unguentum flavums " existing therapeutic domain.
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| CN201210309133.8A CN103622994A (en) | 2012-08-28 | 2012-08-28 | Compound ointment containing borneol, sulfur and realgar |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436101A (en) * | 2014-11-05 | 2015-03-25 | 张学举 | Externally applied traditional Chinese medicine ointment for treating acne rosacea and preparation method thereof |
| CN105561198A (en) * | 2016-02-01 | 2016-05-11 | 项庄勇 | External-use medicine for treating herpes zoster and preparation method thereof |
| CN114948993A (en) * | 2022-03-29 | 2022-08-30 | 罗露曦 | Preparation method and application of skin gel for treating tinea capitis, skin eczema and acne |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433552A (en) * | 2008-11-27 | 2009-05-20 | 崔凤玉 | External-use medicament for treating psora |
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2012
- 2012-08-28 CN CN201210309133.8A patent/CN103622994A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433552A (en) * | 2008-11-27 | 2009-05-20 | 崔凤玉 | External-use medicament for treating psora |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436101A (en) * | 2014-11-05 | 2015-03-25 | 张学举 | Externally applied traditional Chinese medicine ointment for treating acne rosacea and preparation method thereof |
| CN105561198A (en) * | 2016-02-01 | 2016-05-11 | 项庄勇 | External-use medicine for treating herpes zoster and preparation method thereof |
| CN114948993A (en) * | 2022-03-29 | 2022-08-30 | 罗露曦 | Preparation method and application of skin gel for treating tinea capitis, skin eczema and acne |
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Application publication date: 20140312 |