CN111388366A - Acupoint bead-blasting traditional Chinese medicine mask, preparation method and application - Google Patents
Acupoint bead-blasting traditional Chinese medicine mask, preparation method and application Download PDFInfo
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- CN111388366A CN111388366A CN202010217707.3A CN202010217707A CN111388366A CN 111388366 A CN111388366 A CN 111388366A CN 202010217707 A CN202010217707 A CN 202010217707A CN 111388366 A CN111388366 A CN 111388366A
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
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- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
- A61H2201/105—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy with means for delivering media, e.g. drugs or cosmetics
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Abstract
The invention relates to an acupoint bead-blasting traditional Chinese medicine mask, a preparation method and application thereof, wherein the mask comprises the following components: 3-7 parts of wormwood, 1-5 parts of ligusticum wallichii, 0.5-1.5 parts of safflower, 1-3 parts of tribulus terrestris, 1-3 parts of radix angelicae, 1-3 parts of rhizoma nardostachyos, 1-3 parts of white chrysanthemum, 1.5-2.5 parts of xanthan gum, 0.8-1.5 parts of sodium alginate, 0.5-2 parts of sodium carboxymethylcellulose and 20-30 parts of olive oil. Processing raw materials into freeze-dried powder; heating olive oil to 42-47 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, uniformly stirring, mixing with the freeze-dried powder, uniformly stirring, injecting into a dripping pill machine, preparing a mould with a pill diameter of 3mm, and dripping the glue solution into the mould for pre-molding; sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead; the bead blasting type traditional Chinese medicine mask disclosed by the invention has the advantages that the efficacy of the medicine is concentrated and the acupuncture points are stimulated, the double effects of the medicine and the acupuncture points can be exerted, the medicinal materials are saved, the side effect is small, and the effects of moisturizing, whitening, wrinkle removing, speckle lightening, acne removing and the like are realized.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine skin care products, in particular to an acupoint bead blasting type traditional Chinese medicine mask, a preparation method and application.
Background
The theory of traditional Chinese medicine, namely the basic theory of traditional Chinese medicine, is called "middle base" for short. The traditional Chinese medicine is the foundation and the core of a traditional Chinese medicine system with the greatest characteristics of the overall concept of three philosophies of heaven-human unification and the evidence-based view of syndrome differentiation, treatment and similarity (fractal view). The theories of the basic theory of traditional Chinese medicine mainly comprise a fractal yin-yang five-element theory, a visceral manifestation five-system theory (a heart system, a liver system, a spleen system, a lung system and a kidney system), a five-fortune six-qi theory, a qi-blood-essence-body-fluid-spirit theory (qi: information-energy-matter-ternary theory-multivariate theory), a constitutional theory, a etiology theory, a pathogenesis theory and a health preserving theory, a fractal meridian theory and the like, wherein the visceral manifestation is taken as a core, and the information-energy-matter theory is taken as a basis, so that physiological and pathological phenomena of a human body are comprehensively and systematically elucidated and are used for guiding clinical diagnosis and treatment activities.
The holistic concept of traditional Chinese medicine is that "there are many interior types, but there are many exterior types; the appearance is known as the interior; in and out of it ". The skin is the outermost surface of the human body, "the exterior and interior of the body" and the exterior is diseased, so it can be inferred which zang-fu organs are disordered. Most skin diseases are caused by the disorder of the internal organs. Treating the interior with the aim of healing the exterior means treating the disorder in the body, and the exterior is good. Through treatment, the traditional Chinese medicine achieves the healing of skin diseases,
the treatment of the same disease and the treatment of different diseases in the traditional Chinese medicine mean that the same disease has different manifestations in different development stages, and the treatment methods and the medicines are different. For example, eczema is usually manifested as damp-heat in acute progressive stage, such as itching, exudation, erosion, erythema, and blisters, and should be treated mainly by clearing heat and removing dampness. In the sub-acute stage, the skin is relatively thick, itching is also caused, and exudation is not much, so that the spleen-tonifying and dampness-removing medicines are added. In the chronic stage, itching, pachynsis, even rhagadia, spleen dampness weakening, but yin impairment, yin nourishing and dampness removing should be used for treatment.
"Ri\28729Zhongwen" Zhongyun: the different Fa Er … … can supplement the treatment of internal diseases, the treatment of external diseases is the treatment of internal diseases, and the treatment of external diseases is the treatment of internal diseases. The traditional Chinese medicine mask is a specific form of external application of traditional Chinese medicines, and has a definite curative effect in the treatment aspects of common facial diseases such as dark yellow and lusterless skin, acne, whelk and pimples. Compared with the traditional facial mask, the traditional Chinese medicine facial mask does not contain chemical components such as alcohol, hormone, artificial pigment, preservative and the like, combines the overall concept and characteristic method and reasonable prescription proportion by the basic theory of traditional Chinese medicine, utilizes the effective components in the traditional Chinese medicine to achieve the beauty effects of improving circulation, cleaning face, beautifying skin, eliminating facial flaws and the like, is very suitable to be used as a cosmetic additive, and is safer, more natural, milder and more lasting in effect compared with the cosmetic taking a chemical synthetic product as a raw material.
The application number is CN201810825166.5, the traditional Chinese medicine mask and the preparation method thereof, the traditional Chinese medicine mask provided by the invention comprises the following raw materials in parts by weight: 8-16 parts of lophatherum gracile extract, 10-4 parts of spirulina extract, 6-10 parts of honeysuckle extract, 5-11 parts of folium isatidis extract, 1-3 parts of banana, 0.2-0.8 part of tartaric acid, 1-6 parts of tremella, 2-4 parts of radix angelicae, 1-5 parts of poria cocos, 4-8 parts of pearl powder, 2-5 parts of astragalus membranaceus, 4-6 parts of gardenia, 1-6 parts of honey, 1-3 parts of olive oil, 20-30 parts of papaya water and 0.05-0.1 part of xanthan gum. The invention is prepared by the steps of extracting limited components of traditional Chinese medicines, mixing, sterilizing, drying and the like. The traditional Chinese medicine mask disclosed by the invention utilizes a reinforcing system consisting of olive oil, pawpaw water and xanthan gum to improve the effectiveness of the traditional Chinese medicine mask in treating acne, acne marks and pigmentation, does not contain any chemical additive, does not contain a preservative, is natural, mild and non-irritant, and is suitable for people with various skin qualities.
CN201710737858.X A traditional Chinese medicine facial mask, and a preparation method and a use method thereof, the invention provides a traditional Chinese medicine facial mask, and a preparation method and a use method thereof, which are safe, efficient, and capable of whitening, removing freckles and wrinkles. A traditional Chinese medicine facial mask comprises, by weight, 20-28 parts of silk fibroin, 5-10 parts of cimicifuga foetida, 11-15 parts of gynostemma pentaphylla, 3-6 parts of Chinese yew, 8-13 parts of corn stigma, 5-8 parts of glossy privet fruit, 2-5 parts of artemisinin, 2-4 parts of collagen and 2-6 parts of a film forming agent. The formula of the invention has good freckle removing effect, wrinkle removing, skin whitening, skin glossiness restoring, skin elasticity restoring, pore shrinking effect, blackhead reciprocating effect, pox removing effect and pox scar lightening; the film forming agent formula of 0.5-1.6 parts of polyvinyl alcohol, 0.2-1.0 part of pectin, 0.4-1.0 part of gellan gum and 0.9-2.4 parts of xanthan gum, together with other components of the mask, forms a film with good film forming speed, film forming air permeability and film forming tension strength, thereby further improving the absorption of the mask components by the skin and providing the effects of whitening, removing freckles, removing wrinkles, removing scars and the like of the mask on the skin.
The invention discloses a whitening, freckle-removing and acne-removing traditional Chinese medicine mask which is under the application number of CN201910755110.1 and comprises main materials and auxiliary materials, and is characterized in that the main materials comprise the following components in parts by weight: 10-30 parts of sanguis Draxonis, 10-20 parts of bletilla striata, 12-34 parts of Ampelopsis japonica, 22-50 parts of rhizoma typhonii, 10-20 parts of clove, 13-25 parts of pseudo-ginseng, 14-32 parts of litharge, 5-10 parts of sulfur, 5-20 parts of rhizoma smilacis glabrae, 10-20 parts of raw rhubarb and 30-50 parts of deep sea pearl powder; the adjuvants are vinegar and Mel; grinding the main material into powder, mixing with the auxiliary material to obtain paste, and applying on face to form facial mask. The pearl powder mask prepared by the invention has the effects of whitening and tendering skin, reducing pigmentation, resisting bacteria and diminishing inflammation, cooling blood and activating blood, and activating meridians and collaterals; can deeply remove facial dirt and effectively treat facial diseases such as acne, pimple, acne and the like generated on the face, and has the characteristics of simple use method, mild drug effect and good effect.
The application numbers of the three inventions are CN201810825166.5, CN201710737858.X and CN20191075511, the three inventions have the following defects that ① traditional Chinese medicine components are dispersed in the whole mask, so that the efficacy of the traditional Chinese medicine is not concentrated enough, and the stimulation to other positions of the face is increased once the medicine concentration is increased, so that adverse reactions such as allergy and the like can be caused, ② causes medicine waste and the mask cost is increased, ③ achieves the beautifying effects of removing freckles, wrinkles, whitening and removing acnes by externally applying the mask to the face, and the medicines are not applied to the meridian points of the face, so that the effects of dredging the meridians or stimulating the meridian points to further beautify and keep health.
Application number CN201811203301.9, an acupuncture point facial mask cloth, including facial mask cloth base member, establish eyelet, nose broken lines seam and mouth hole on facial mask cloth base member, its characterized in that: the facial mask cloth substrate is provided with Cuanzhu acupoint salient points and temple acupoint salient points; cheek lath acupoint convex points, Yingxiang acupoint convex points, ditch acupoint convex points and Chengjiang acupoint convex points. By adopting the structure, when people apply the facial mask, the convex body material is close to the skin of the face, and the purposes of beautifying, maintaining and preserving health are achieved by massaging (extruding) acupuncture points on the facial mask or beating the facial mask with palms, and the weight percentage of the formula is as follows: 40% of polyvinyl chloride paste resin (with the polymerization degree of 1100-1400); DOTP; 53 percent; filler SiO27 percent; the balance is oleophylic pearl powder or oleophylic pigment.
The application number of CN201811203301.9 is that ① the invention uses chemical synthesis agent, which has the disadvantages of large toxic and side effects, and not treating the symptoms and root causes, ② the invention is inconvenient because it needs to massage (squeeze) the points on the face mask or flap the face mask with palm when in use.
Aiming at the problems, the inventor adopts a traditional Chinese medicine mask which stimulates the facial acupuncture points to administer medicine through an exploded bead-shaped mask, can combine the whole effects of the acupuncture points and the mask, concentrates the exploded bead components near the facial acupuncture points, increases the concentration of the traditional Chinese medicine at the acupuncture points, reduces the concentration of the medicine along with the diffusion to the periphery, limits the medicine stimulating the acupuncture points to the local acupuncture points or the periphery, and does not stimulate other parts of skin; secondly, the traditional Chinese medicine compound is adopted to stimulate the acupuncture points in a targeted manner, so that the corresponding facial acupuncture points can achieve better treatment effect; thirdly, the bead blasting medicine is concentrated on the local parts of the channels and the acupoints, so that the interference on other parts is avoided, the skin burden is not increased, more effects are achieved, and the cost is lower. When in use, the facial mask is applied on the face, and then the explosive beads at corresponding acupuncture points are pinched and exploded to release the medicine in the explosive beads, so as to stimulate the acupuncture points and achieve corresponding effects by stimulating the acupuncture points.
Disclosure of Invention
The invention aims to establish an acupoint bead-blasting traditional Chinese medicine mask, a preparation method and application.
The invention relates to an acupoint bead-blasting traditional Chinese medicine mask which is prepared from the following raw materials: the facial mask is prepared from the following raw materials: 3-7 parts of wormwood, 1-5 parts of ligusticum wallichii, 0.5-1.5 parts of safflower, 1-3 parts of tribulus terrestris, 1-3 parts of radix angelicae, 1-3 parts of rhizoma nardostachyos and 1-3 parts of white chrysanthemum.
The traditional Chinese medicine mask also comprises a pharmaceutically acceptable dosage form prepared by pharmaceutically acceptable auxiliary materials.
The auxiliary materials of the invention are: 1.5-2.5 parts of xanthan gum, 0.8-1.5 parts of sodium alginate, 0.5-2 parts of sodium carboxymethylcellulose and 20-30 parts of olive oil.
The traditional Chinese medicine mask disclosed by the invention consists of the following raw and auxiliary materials: 3-7 parts of wormwood, 1-5 parts of ligusticum wallichii, 0.5-1.5 parts of safflower, 1-3 parts of tribulus terrestris, 1-3 parts of radix angelicae, 1-3 parts of rhizoma nardostachyos, 1-3 parts of white chrysanthemum, 1.5-2.5 parts of xanthan gum, 0.8-1.5 parts of sodium alginate, 0.5-2 parts of sodium carboxymethylcellulose and 20-30 parts of olive oil.
Preferably, the traditional Chinese medicine mask disclosed by the invention consists of the following raw and auxiliary materials: 5 parts of wormwood, 3 parts of ligusticum wallichii, 1 part of safflower, 2 parts of tribulus terrestris, 2 parts of radix angelicae, 2 parts of nardostachys chinensis, 2 parts of white chrysanthemum, 1.8-2.2 parts of xanthan gum, 1-1.2 parts of sodium alginate, 0.8-1.5 parts of sodium carboxymethylcellulose and 22-28 parts of olive oil.
Further preferably, the traditional Chinese medicine mask provided by the invention comprises the following raw and auxiliary materials: 5 parts of wormwood, 3 parts of ligusticum wallichii, 1 part of safflower, 2 parts of tribulus terrestris, 2 parts of angelica dahurica, 2 parts of nardostachys chinensis, 2 parts of white chrysanthemum, 2 parts of xanthan gum, 1.2 parts of sodium alginate, 1 part of sodium carboxymethylcellulose and 25 parts of olive oil.
The preparation method of the traditional Chinese medicine mask comprises the following steps:
1) adding 5-8 times of 40-60% methanol into the raw materials, extracting for 2-4 times, each time for 20-40 minutes, and filtering; pre-freezing the filtrate at-50 to-20 ℃ for 1.5 to 3 hours; controlling the thickness of the pre-frozen medicine to be 5-7 mm, and drying for 7-11 hours under the conditions that the pressure is 30-50 Pa and the temperature is 53-65 ℃ to obtain freeze-dried powder;
2) heating olive oil to 42-47 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and uniformly stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Preferably, the preparation method of the traditional Chinese medicine mask comprises the following steps:
1) extracting the raw materials with 7 times of 50% methanol for 3 times, each for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of 40Pa and 60 ℃ for 9 hours to obtain lyophilized powder;
2) heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
The facial acupuncture points of the mask with the function of popping the beads are Yingxiang acupuncture point, auricular acupuncture point, Quanliao acupuncture point, Sibai acupuncture point, Jiache acupuncture point, Xiaguan acupuncture point, Yangbai acupuncture point, Chengjiang acupuncture point and Taiyang acupuncture point.
The placement positions of the blasting beads on the non-woven fabric are determined according to the corresponding positions of the Yingxiang acupoint, the Er-Men acupoint, the Quanliao acupoint, the Sibai acupoint, the Jiache acupoint, the Xiaguan acupoint, the Yangbai acupoint, the Chengjiang acupoint and the Taiyang acupoint in the human face acupoints, and can be placed at the corresponding positions of the acupoints or at the positions of 0.1-0.5 cm of the corresponding acupoints. The acupuncture points are shown in figure 1.
The bead blasting fixing method can be characterized in that a thermosol film is placed on the contact surface of two layers of non-woven fabrics and heated to 45-60 ℃, and the bead blasting can be fixed when the thermosol film generates viscosity and pressure, and can also be fixed by adopting conventional technologies in the field such as thread sewing and the like.
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The method comprises the following steps of (1) conveying a die into a dryer for drying and molding to obtain a finished product of the popping bead; the drying temperature is 60-80 ℃ and the drying time is 0.5-1.5 hours.
The bead blasting type mask disclosed by the invention is applied to the aspects of moisturizing, whitening, wrinkle removing, speckle lightening and acne removing.
The invention has the following beneficial effects:
1. disadvantages of the prior art and advantages of the present invention
The Chinese patent application numbers are CN201810825166.5, CN201710737858.X and CN20191075511, and the three inventions belong to traditional Chinese medicine facial masks, but the defects that ① traditional Chinese medicine components are dispersed in the whole facial mask, so that the medicine efficacy is not concentrated enough, and once the medicine concentration is increased, the stimulation to other positions of the face is increased, so that adverse results such as allergy and the like are possibly caused are increased, ② causes medicine waste and increases the facial mask cost, ③ achieves the beautifying effects of removing freckles, whitening and removing acnes by externally applying the facial mask, and the beautifying effects of dredging channels and collaterals or stimulating the acupoints of the facial channels and cannot be comprehensively achieved.
The Chinese patent application No. CN201811203301.9 has the defects that ① the formula of the mask is a chemical synthesis agent, so that the mask has great toxic and side effects and can treat symptoms and root causes, and ② the mask is inconvenient to use because points on the mask need to be massaged (squeezed) or the palm needs to be used for beating the mask.
The invention can overcome the defects of CN201810825166.5, CN201710737858.X and CN20191075511, and has the advantages that ① increases the concentration of traditional Chinese medicines at acupuncture points, so that the medicine concentration is reduced along with diffusion to the periphery, the medicines stimulating the acupuncture points are limited to local acupuncture points, and skin at other parts is not stimulated, ② adopts traditional Chinese medicine compound stimulation to the acupuncture points in a targeted manner, so that corresponding facial acupuncture points can achieve better treatment effect, ③ concentrates the bead blasting medicines at local acupuncture points, does not cause interference at other parts, does not increase skin burden, achieves more effects, and is lower in cost, and ④ is used, the mask is applied to the face, then the corresponding bead blasting can be pinched to release the medicines in the bead blasting to stimulate the acupuncture points, and achieves the beautifying effect by stimulating the acupuncture points.
2. The bead blasting mask disclosed by the invention acts on facial acupuncture points and is beneficial to the penetration of functional substances into the deep layer of the skin. Meanwhile, the expansion of capillary vessels and the increase of blood microcirculation can greatly promote the absorption and utilization of the cells to the nutrients contained in the mask.
3. The bead blasting mask disclosed by the invention can rapidly activate blood circulation to dissipate blood stasis, expel toxin and detoxify, enhance skin metabolism, promote blood circulation and enable skin pores to absorb after passing through the channels of herbaceous plants, active ingredients are intensively acted on the surface of a problem skin to permeate into the deep part of the skin, the normal function of the skin is recovered, the activity of cells is mobilized, the metabolism of the cells is enhanced, and thus smooth and purer skin is recovered.
4. The invention researches an acupoint bead blasting type traditional Chinese medicine mask with the effects of moisturizing, whitening, removing wrinkles, lightening spots and removing acnes, and through experiments of a face moisturizing performance test, an acne removing performance test, a wrinkle removing performance test, a whitening performance test and a spot lightening performance test, the result of the invention is that all performance test data are superior to the comparative examples: the water-replenishing rate can reach more than 200%, the moisture-preserving rate can reach more than 90%, the melanin inhibition rate in the whitening performance test reaches 60%, and the acne-removing, spot-lightening and wrinkle-removing effects are obvious.
5. The skin irritation test result shows that the mask has no irritation to healthy skin; the pH value of the facial mask is 5.1-5.5, and the facial mask is suitable for the characteristics of normal human skin; the results of high-temperature and low-temperature resistant experiments and centrifugal experiments show that the mask has no change in properties, is easy to store and is convenient to carry.
6. According to the invention, through stability test investigation, the facial mask is tested for appearance, fineness, pH value and centrifugation test within 0-18 months, and the result shows that the facial mask has stable appearance, fineness and pH value, the pH value meets the requirement, and the centrifugation test has no water analysis and layering phenomenon; the facial mask has relatively stable quality in 0 to 18 months, and is suitable for industrial production.
7. The invention is a bead-blasting type facial mask, which combines the mode of combining the existing popular facial mask with the existing facial mask, integrates the advantages of the existing facial mask for beautifying and skin care and the advantages of the traditional Chinese medicine compound for stimulating the acupuncture point and beautifying, saves the cost as much as possible and enlarges the efficacy.
8. The mask disclosed by the invention can achieve the multi-effect through the action of different acupuncture points on one mask, so that the cost is saved, and the beautifying effect is improved.
Description of the drawings:
FIG. 1: face acupoint map (Yingxiang for Yingxiang acupoint, Er Men for Er Men acupoint, Quanliao for Quanliao acupoint, Sibai for Sibai acupoint, Jiache for Jiache acupoint, Xiaguan for Xiaguan acupoint, Yangbai for Yangbai acupoint, Chengjiang for Chengjiang acupoint, Taiyang for Taiyang acupoint).
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The formula is as follows: 5g of wormwood, 3g of ligusticum wallichii, 1g of safflower, 2g of tribulus terrestris, 2g of radix angelicae, 2g of rhizoma nardostachyos, 2g of white chrysanthemum, 2g of xanthan gum, 1.2g of sodium alginate, 1g of sodium carboxymethylcellulose and 25g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 7 times of 50% methanol for 3 times, each for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of 40Pa and 60 ℃ for 9 hours to obtain lyophilized powder;
2) heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 2
The formula is as follows: 3g of wormwood, 1g of ligusticum wallichii, 0.5g of safflower, 1g of tribulus terrestris, 1g of radix angelicae, 1g of rhizoma nardostachyos, 1g of white chrysanthemum, 1.5g of xanthan gum, 0.8g of sodium alginate, 0.5g of sodium carboxymethylcellulose and 20g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 5 times of 40% methanol for 2 times, each for 20min, and filtering; pre-freezing the filtrate at-50 deg.C for 1.5 h; controlling the thickness of the pre-frozen medicine at 5mm, and drying under the conditions of pressure of 30Pa and temperature of 53 deg.C for 7 hr to obtain lyophilized powder;
2) heating olive oil to 42 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 3
The formula is as follows: 7g of wormwood, 5g of ligusticum wallichii, 1.5g of safflower, 3g of tribulus terrestris, 3g of radix angelicae, 3g of rhizoma nardostachyos, 3g of white chrysanthemum, 2.5g of xanthan gum, 1.5g of sodium alginate, 2g of sodium carboxymethylcellulose and 30g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 8 times of 60% methanol for 4 times, each for 40 min, and filtering; pre-freezing the filtrate at-20 deg.C for 3 h; controlling the thickness of the pre-frozen medicine at 7mm, and drying under the conditions of pressure of 50Pa and temperature of 65 ℃ for 11 hours to obtain lyophilized powder;
2) heating olive oil to 47 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 4
The formula is as follows: 4g of wormwood, 2g of ligusticum wallichii, 0.8g of safflower, 1.2g of tribulus terrestris, 1.2g of radix angelicae, 1.2g of rhizoma nardostachyos, 1.2g of white chrysanthemum, 1.6g of xanthan gum, 0.8g of sodium alginate, 0.6g of sodium carboxymethylcellulose and 21g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 5.5 times of 42% methanol for 3 times, each for 22 min, and filtering; pre-freezing the filtrate at-45 deg.C for 1.6 h; controlling the thickness of the pre-frozen medicine at 5.2mm, and drying under the conditions of pressure of 32Pa and temperature of 54 ℃ for 7.2 hours to obtain lyophilized powder;
2) heating olive oil to 43 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 5
The formula is as follows: 5g of wormwood, 2g of ligusticum wallichii, 1g of safflower, 1.5g of tribulus terrestris, 1.5g of radix angelicae, 1.5g of rhizoma nardostachyos, 1.5g of white chrysanthemum, 1.8g of xanthan gum, 1g of sodium alginate, 0.7g of sodium carboxymethylcellulose and 23g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 6 times of 45% methanol for 3 times, each time for 25 min, and filtering; pre-freezing the filtrate at-40 deg.C for 1.8 h; controlling the thickness of the pre-frozen medicine at 5.5mm, and drying under the conditions of 35Pa and 54 ℃ for 7.5 hours to obtain lyophilized powder;
2) heating olive oil to 44 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 6
The formula is as follows: 6g of wormwood, 3g of ligusticum wallichii, 1.2g of safflower, 1.8g of tribulus terrestris, 1.8g of radix angelicae, 1.8g of rhizoma nardostachyos, 1.8g of white chrysanthemum, 2g of xanthan gum, 1.1g of sodium alginate, 0.8g of sodium carboxymethylcellulose and 24g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 6 times of 48% methanol for 2 times, each for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 5.8mm, and drying under the conditions of 40Pa pressure and 58 ℃ for 8 hours to obtain lyophilized powder;
2) heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 7
The formula is as follows: 7g of wormwood, 4g of ligusticum wallichii, 1.5g of safflower, 2g of tribulus terrestris, 2g of radix angelicae, 2g of rhizoma nardostachyos, 2g of white chrysanthemum, 2.1g of xanthan gum, 1.2g of sodium alginate, 0.9g of sodium carboxymethylcellulose and 25g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 7 times of 50% methanol for 4 times (each for 32 min), and filtering; pre-freezing the filtrate at-32 deg.C for 2.2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of 42Pa and 59 ℃ for 9 hours to obtain lyophilized powder;
2) heating olive oil to 46 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and uniformly stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 8
The formula is as follows: 5g of wormwood, 5g of ligusticum wallichii, 1g of safflower, 2.5g of tribulus terrestris, 2.5g of radix angelicae, 2.5g of rhizoma nardostachyos, 2.5g of white chrysanthemum, 2.2g of xanthan gum, 1.3g of sodium alginate, 1.2g of sodium carboxymethylcellulose and 26g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 8 times of 52% methanol for 4 times, each for 33 min, and filtering; pre-freezing the filtrate at-30 deg.C for 2.4 h; controlling the thickness of the pre-frozen medicine at 5mm, and drying under the conditions of 43Pa and 60 ℃ for 10 hours to obtain lyophilized powder;
2) heating olive oil to 47 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 9
The formula is as follows: 6g of wormwood, 3g of ligusticum wallichii, 1.3g of safflower, 2.8g of tribulus terrestris, 2.8g of radix angelicae, 2.8g of rhizoma nardostachyos, 2.8g of white chrysanthemum, 2.3g of xanthan gum, 1.4g of sodium alginate, 1.4g of sodium carboxymethylcellulose and 27g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 6 times of 55% methanol for 4 times, each for 35 min, and filtering; pre-freezing the filtrate at-28 deg.C for 2.5 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of pressure of 45Pa and temperature of 61 deg.C for 8 hr to obtain lyophilized powder;
2) heating olive oil to 42 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 10
The formula is as follows: 5g of wormwood, 3g of ligusticum wallichii, 1g of safflower, 3g of tribulus terrestris, 3g of angelica dahurica, 3g of nardostachys chinensis, 3g of white chrysanthemum, 2.4g of xanthan gum, 1.5g of sodium alginate, 1.6g of sodium carboxymethylcellulose and 28g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 7 times of 58% methanol for 3 times, each time for 38 min, and filtering; pre-freezing the filtrate at-25 deg.C for 2.8 h; controlling the thickness of the pre-frozen medicine at 7mm, and drying under the conditions of pressure of 46Pa and temperature of 62 ℃ for 9 hours to obtain lyophilized powder;
2) heating olive oil to 43 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 11
The formula is as follows: 6g of wormwood, 2g of ligusticum wallichii, 1.5g of safflower, 2g of tribulus terrestris, 2g of radix angelicae, 2g of rhizoma nardostachyos, 2g of white chrysanthemum, 2.5g of xanthan gum, 1.2g of sodium alginate, 1.8g of sodium carboxymethylcellulose and 29g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 8 times of 60% methanol for 2 times, each time for 39 min, and filtering; pre-freezing the filtrate at-23 deg.C for 2.9 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of 48Pa and 64 ℃ for 10 hours to obtain lyophilized powder;
2) heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Example 12
The formula is as follows: 4g of wormwood, 3g of ligusticum wallichii, 5g of safflower, 3g of tribulus terrestris, 3g of angelica dahurica, 2g of nardostachys chinensis, 1g of white chrysanthemum, 2.3g of xanthan gum, 0.9g of sodium alginate, 1.9g of sodium carboxymethylcellulose and 30g of olive oil.
The preparation method comprises the following steps: 1) extracting the raw materials with 6 times of 50% methanol for 3 times, each for 30min, and filtering; pre-freezing the filtrate at-21 deg.C for 3 h; controlling the thickness of the pre-frozen medicine at 6.5mm, and drying under the conditions of 49Pa and 65 ℃ for 11 hours to obtain lyophilized powder;
2) heating olive oil to 46 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and uniformly stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
To further verify the feasibility of the present invention, the inventors performed a series of experiments, as follows: 1 experimental instrument:
pill dropping machines (DWJ-S2, Tanzhou high-class pharmaceutical machinery Co., Ltd.), freeze-drying machines (TF-L FD-10A, Shanghai Tuo mechanical equipments Co., Ltd.), (electrothermal constant temperature drying ovens (HPD-101-3A, Henzhou Huapoda teaching instruments Co., Ltd.), digital display constant temperature water bath (DRRH-S4, Shanghai Shuijie experimental equipments Co., Ltd.), electronic balances (FA2-204-N, Shanghai Jinghai instruments Co., Ltd.), thermal collection magnetic stirrers (DF-101S, Jiangsu Ke analysis instruments Co., Ltd.), PH meter testers (PHS-25, Shanghai instruments electro scientific instruments Co., Ltd.), desktop electric centrifuges (80-2, Henzhou Jintan instruments Co., Ltd.), low temperature refrigerators (YB-60-288, Henzhou Henghuan Henglong instruments Co., Ltd.), skin detectors (Corneometeric CM285, Guangzhou Alphaffy medical treatment Co., Ltd.), skin pigment analyzers (Mevie 16, Mitsu Tech technologies).
2 screening of formula of bead-blasting type mask
2.1 screening of raw and auxiliary materials
2.1.1 basis for raw Material selection
According to the efficacy and the indication of the traditional Chinese medicines, the traditional Chinese medicines with the efficacies of promoting blood circulation and promoting qi circulation, warming channels and stopping bleeding, eliminating dampness and stopping leucorrhea, reducing swelling and expelling pus, regulating qi and relieving pain, and dispelling melancholy and activating spleen are selected for treating skin pruritus, sore and ulcer swelling and pain and irregular menstruation.
2.1.2 screening of the starting materials
Tentatively taking the following medicines as raw materials:
and (3) moxa: warming channels, stopping bleeding, dispelling cold, and relieving pain; it has effects in eliminating dampness, killing parasite, relieving itching, and resisting allergy. Can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, fetal leakage, lower blood, lower abdomen psychroalgia, menoxenia, and infertility due to cold womb; it can be used for treating skin pruritus and allergy.
Ligusticum wallichii: promote blood circulation and move qi, dispel wind and alleviate pain. It is applicable to various diseases caused by blood stasis.
Safflower: promoting blood circulation, removing blood stasis, relieving swelling and pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, thoracic and hypochondriac pain, traumatic injury, and pyocutaneous disease with swelling and pain.
Tribulus terrestris: calming the liver, relieving depression, promoting blood circulation, expelling pathogenic wind, improving eyesight, and relieving itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus.
Radix angelicae: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, and relieving swelling and pus for common cold, headache, supercilium pain, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, and sore and ulcer with swelling and pain.
And (3) rhizoma nardostachyos: regulating qi-flowing for relieving pain, resolving stagnation and activating spleen; dispel dampness and relieve swelling for external use. Can be used for treating abdominal distention, anorexia, and emesis; it is used externally to treat toothache, beriberi and other swelling and toxin.
White chrysanthemum: dispel wind and clear heat, pacify liver and improve vision, clear heat and remove toxicity. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling.
2.2 screening of adjuvants
2.2.1 basis for screening of adjuvants
According to the requirements of cosmetic auxiliary materials, proper auxiliary materials are selected by combining the properties of the 2.1.2 Chinese medicaments.
2.2.2 screening of adjuvants
Heating olive oil, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, uniformly stirring, after the auxiliary materials are fully swelled or dissolved, parallelly adding mixed powder of 7 traditional Chinese medicines in the same amount of 2.1.2, stirring until the medicines are observed to be dissolved by naked eyes, preliminarily forming a mask glue solution, respectively taking 5m L masks in 4 10m L small plastic test tubes, carrying out centrifugation for 30min, carrying out comprehensive scoring according to the scoring standard in table 1, wherein the total score of all indexes is 10, and the scoring result is shown in table 1.
TABLE 1 screening results of adjuvants
The results of the data in the table show that the comprehensive scores of all the auxiliary materials are more than 9.0, wherein the comprehensive score of the olive oil is the highest, and the comprehensive score of the xanthan gum is the second highest. The comprehensive scores of the sodium carboxymethylcellulose and the sodium alginate are not greatly different, and the mask is unchanged after centrifugation, so that the olive oil, the xanthan gum, the sodium carboxymethylcellulose and the sodium alginate serving as drug substrates can uniformly disperse the drugs, no agglomeration or precipitation is caused after centrifugation, and the properties are stable.
Selection of initial formula of 3 bead blasting type mask
According to the efficacy and the main treatment symptoms of the traditional Chinese medicine and the dosage of auxiliary materials in cosmetics, and in combination with the theory of treatment based on syndrome differentiation of traditional Chinese medicine, three formulas are preliminarily designed, wherein the three formulas are respectively as follows:
the formula I is as follows: 5g of wormwood, 3g of ligusticum wallichii, 1g of safflower, 2g of tribulus terrestris, 2g of radix angelicae, 2g of rhizoma nardostachyos, 2g of white chrysanthemum, 2g of xanthan gum, 1.2g of sodium alginate, 1g of sodium carboxymethylcellulose and 25g of olive oil.
And a second formula: 2g of wormwood, 2g of ligusticum wallichii, 0.3g of safflower, 0.5g of tribulus terrestris, 0.5g of radix angelicae, 0.5g of rhizoma nardostachyos, 0.5g of white chrysanthemum, 0.2g of xanthan gum, 0.5g of sodium alginate, 0.3g of sodium carboxymethylcellulose and 15g of olive oil.
And the formula III: 10g of wormwood, 10g of ligusticum wallichii, 8g of safflower, 5g of tribulus terrestris, 5g of radix angelicae, 5g of rhizoma nardostachyos, 5g of white chrysanthemum, 5g of xanthan gum, 3g of sodium alginate, 3g of sodium carboxymethylcellulose and 40g of olive oil.
Selection of 4 bead blasting type mask process
4.1 selection of drug extract solvent:
according to common solvents of traditional Chinese medicinal materials, water, 25% methanol, 50% ethanol, 75% ethanol and ethyl acetate are respectively weighed to be 10m L, 0.5g of wormwood powder, ligusticum wallichii powder, safflower powder, tribulus terrestris powder, angelica dahurica powder, rhizoma nardostachyos powder and feverfew powder are respectively added, stirring is carried out for 5 minutes, and the dissolution conditions of the powders are shown in table 2 according to the expression of the solubility in four valves of the Chinese pharmacopoeia.
Table 2 solvent selection results table
As a result: through comprehensive analysis of the dissolution conditions of the medicinal material powders in different solvents, the relative solubility of each medicament in 50% methanol is the best, so that the invention selects 50% methanol as the solvent.
4.2 treatment method selection of the medicine:
according to the properties of 7 medicaments in 2.1.2, three extraction methods are preliminarily designed, and respectively as follows:
method 1
Extracting the first, second and third formulas of "3" with 7 times of 50% methanol for 3 times (each for 30 min), and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under 40Pa and 60 deg.C for 9 hr to obtain lyophilized powder.
Method two
Extracting the first, second and third formulas of "3" with 7 times of 50% methanol for 3 times (each for 30 min), and filtering; volatilizing the filtrate, drying by a drying method, and collecting dry powder;
method III
Extracting the first, second and third formulas of "3" with 7 times of 50% methanol for 3 times (each for 30 min), and filtering; volatilizing the filtrate, drying under reduced pressure for 4 hours, and collecting dry powder;
as a result: the sample treated by the method I has uniform powder thickness and loose texture, is easy to be uniformly mixed with auxiliary materials, and is not easy to deteriorate and easy to store after being pre-frozen at low temperature; the sample powder treated by the methods II and III is easy to agglomerate, has relatively hard texture and is not beneficial to being uniformly mixed with auxiliary materials; therefore, the invention selects 'method one' as the preferred scheme.
4.3 selection of bead blasting type surface film process:
4.3.1 the efficacies and main indications of face acupuncture points are as follows:
① Yingxiang acupoint has effects in expelling pathogenic wind, dredging meridians, and relieving nasal obstruction, and can be used for treating facial distortion, rosacea, acne, facial spasm, facial pruritus, and edema.
② the ERMEN acupoint has effects of dredging ear orifice, and dispelling pathogenic heat, and can be used for treating facial distortion, external ear eczema, ear furuncle, tinnitus, deafness, and temporomandibular joint syndrome.
③ ZUANLIAO acupoint has effects in dredging meridian passage, caring skin, and removing wrinkle, and can be used for treating facial distortion, cyclomastopathy, cheilosis, gomaschalia, dark macula, acne, and facial wrinkle.
④ the four white points are used for dredging channels, activating collaterals, nourishing eyes, and improving eyesight, and can be used for treating facial distortion, blackish facial wrinkle, eyelid edema, pouch, cyclothymia, dark circle, myopia, hypermetropia, and strabismus.
⑤ the buccal acupoint has wrinkle removing, collateral flow activating, and analgesic effects, and can be used for treating facial distortion, facial wrinkle, dark macula, acne, myospasm, mandibular joint dysfunction, and toothache.
⑥ the JIANGJING acupoint has wrinkle removing, collateral flow activating, and analgesic effects, and can be used for treating facial distortion, facial wrinkle, cutis laxa, facial dark spot, acne, joint disorder syndrome, and toothache.
⑦ YANGBAI acupoint has the effects of expelling pathogenic wind, and expelling collateral obstruction, and can be used for treating facial distortion, facial spasm, supracytoptosis, and facial wrinkle.
⑧ Chengjiang acupoint has the effects of expelling pathogenic wind, dredging collaterals, and promoting fluid production.
⑨ Taiyang acupoint, QINGGANMINGMU, TONGLUOZHITONG, is used for treating migraine, facial paralysis, facial pain, conjunctival congestion, swelling and pain, hordeolum, nebula, eye dryness, toothache, trigeminal neuralgia, facial paralysis, acute conjunctivitis, hordeolum, etc.
4.3.2 selection of Process
According to the general consideration of the efficacy of the '4.3.1' acupoint and the efficacy of the '2.1.2' medicine, the design of the bead-blasting type mask is selected by combining the theory of dialectical treatment of traditional Chinese medicine, and the placement position of the bead blasting is determined according to the corresponding positions of the Yingxiang acupoint, the auricular acupoint, the zygosaur acupoint, the Sibai acupoint, the Jiache acupoint, the Xiaguan acupoint, the Yangbai acupoint, the Chengjiang acupoint and the Taiyang acupoint in the human face acupoint, wherein the acupoint is shown in figure 1. When in use, the blasting beads are pinched at corresponding acupuncture points, so that the traditional Chinese medicine components in the blasting beads can be exuded to stimulate the corresponding acupuncture points, thereby achieving the effect of treatment; then three methods are preliminarily designed according to a preferred solvent (50% methanol) for extracting the medicine of 4.1 and a method one of 4.2 (the raw material is added with 7 times of 50% methanol for extraction for 3 times, each time is 30 minutes, filtration is carried out, the filtrate is pre-frozen at minus 35 ℃ for 2 hours, the thickness of the pre-frozen medicine is controlled at 6mm, and the pre-frozen medicine is dried for 9 hours under the conditions that the pressure is 40Pa and the temperature is 60 ℃ to obtain freeze-dried powder), wherein the three methods are respectively as follows:
method IV
Step 1: extracting the first, second and third formulas of formula I, II and III in the step 3 with 7 times of 50% methanol for 3 times, each time for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, drying under the conditions of 40Pa and 60 ℃ for 9 hours to obtain lyophilized powder, and then respectively processing according to the following steps;
step 2: heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
and step 3: uniformly stirring the freeze-dried powder and the auxiliary materials in the step (2), injecting the mixture into a pill dropping machine, preparing a mould with the diameter of 3mm for pill making, and dropping glue solution into the mould for pre-molding;
and 4, step 4: sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
and 5: the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
Method five
Step 1: extracting the first, second and third formulas of formula I, II and III in the step 3 with 7 times of 50% methanol for 3 times, each time for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, drying under the conditions of 40Pa and 60 ℃ for 9 hours to obtain lyophilized powder, and then respectively processing according to the following steps;
step 2, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose into olive oil, and uniformly stirring;
step 3, uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2, injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping glue solution into the mould for pre-molding;
step 4, the mould is sent into a dryer for drying and molding to obtain a finished product of the popping bead;
and 5, putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, fixing the bead blasting to obtain the bead blasting type traditional Chinese medicine mask, and when the bead blasting type traditional Chinese medicine mask is used, the bead blasting can be pinched to enable traditional Chinese medicine components in the bead blasting to seep out to stimulate the corresponding acupuncture point to play a corresponding role.
The method six:
step 1: extracting the first, second and third formulas of formula I, II and III in the step 3 with 7 times of 50% methanol for 3 times, each time for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, drying under 40Pa and 60 deg.C for 9 hr to obtain lyophilized powder, and processing according to the following steps.
Step 2: heating olive oil to 50-60 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and uniformly stirring;
and step 3: uniformly stirring the freeze-dried powder and the auxiliary materials in the step (2), injecting the mixture into a pill dropping machine, preparing a mould with the diameter of 3mm for pill making, and dropping glue solution into the mould for pre-molding;
and 4, step 4: sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
and 5: the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
4.4 Experimental methods and results
And (4) scoring the bead blasting mask, and making a comprehensive score for the bead blasting mask prepared in the top grade according to the scoring standard in the table 3, wherein the comprehensive score is the sum of all indexes and is 5 points.
TABLE 3 mask Scoring standards
According to the scoring standards in the table 2, the prepared popping bead facial mask is subjected to preliminary screening scoring from the aspects of solubility and centrifugation, the scoring results are four grades of excellent (2.0-2.5), good (1.0-1.9), medium (0.4-0.9) and poor (0-0.3), and because the screening objects in the experiment are different, the scoring mode has two modes of comprehensive scoring and single scoring. The comprehensive score is that the score is respectively carried out from two angles of solubility and centrifugation degree, the comprehensive score is the sum of the scores of all indexes, and the full score is 5; and the single item score means that one of the two items is selected for scoring, and the full score is 2.5. The formulations and process combinations are shown in table 4.
Table 4 verification of the experimental results for the formulations and process combinations
As a result: according to the data in the table, the single item score and the comprehensive score of the combination of the formula one and the process four are the highest, so the formula one and the process four are the preferred schemes. Is that
Step 1: extracting 5g of wormwood, 3g of ligusticum wallichii, 1g of safflower, 2g of tribulus terrestris, 2g of angelica dahurica, 2g of nardostachys chinensis, 2g of white chrysanthemum, 2g of xanthan gum, 1.2g of sodium alginate, 1g of sodium carboxymethylcellulose and 25g of olive oil with 7 times of 50% methanol for 3 times, each time for 30 minutes, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under 40Pa and 60 deg.C for 9 hr to obtain lyophilized powder.
Step 2: heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
and step 3: uniformly stirring the freeze-dried powder and the auxiliary materials in the step (2), injecting the mixture into a pill dropping machine, preparing a mould with the diameter of 3mm for pill making, and dropping glue solution into the mould for pre-molding;
and 4, step 4: sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
and 5: the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
5 quality evaluation test of the invention
5.1 appearance Properties and fineness
Taking 0.5g of each product of examples 1, 2 and 3, putting the product into a test tube with the thickness of 10m L after being pinched and broken, observing the appearance character, taking the finished product, coating the product on the back of a hand after being pinched and broken, and evaluating the fineness of the product through sensory indexes.
And (4) checking results: the product is brown transparent jelly, uniform, fine, glossy, smooth to touch and moderate in viscosity.
5.2 pH value
0.5g of each of the products of examples 1, 2 and 3 was taken, kneaded, dissolved in L m of distilled water, kept at 40 ℃ for 30min, cooled to room temperature, and measured for pH.
As a result: example 1, pH 5.1; example 2, pH 5.5, example 3, pH 5.4. The pH value of the skin is optimal between pH5.0 and 5.6, and the pH results of 3 examples are in the range.
5.3 simulation experiment for in vitro moisture retention
In order to better simulate human skin, a layer of 3M medical breathable adhesive tape is selected to be used for manufacturing a simulation device in the experiment. In the experiment, the temperature is kept at room temperature, and the 'examples 1, 2 and 3' are weighed; "comparative example 1 (application No. CN 201811203301.9)"; 0.5g each of the masks of "comparative example 2 (commercially available)" was kneaded, applied to the surface of a simulation apparatus, left at room temperature for 1 hour, and then weighed, and the moisture retention rate was calculated, and the results are shown in Table 5.
Moisture retention (100%) [ (weight of sample after leaving for 1 h-3M patch weight)/weight of sample before leaving ] × 100%
TABLE 5 in vitro moisturizing test results
As a result: from the above test results, the moisturizing rate data of "examples 1, 2, and 3" is larger than that of "comparative examples 1 and 2", so that it is demonstrated that the facial mask of the present invention has a significant moisturizing effect in the in vitro moisturizing simulation experiment.
5.4 centrifugation experiments
At room temperature, 5g of each of the products of examples 1, 2 and 3 was kneaded, and then put into a centrifuge tube of 10m L, and the centrifuge tube was rotated at 1000, 2000, 3000, 4000 and 5000rpm for 10min to observe whether or not the sample was analyzed for water.
As a result: no delamination occurred.
5.5 skin irritation test
Three parts (proper amount) of the products of the examples 1, 2 and 3 are taken in parallel, the three parts are respectively smeared on the inner skin of the left wrist of a healthy human body after being pinched and broken, the smearing is carried out for three times, the smearing is carried out for 24 hours once, and the naked eye observation is carried out after 24 hours.
As a result: three parts (proper amount) of the products of the examples 1, 2 and 3 are taken in parallel, the three parts are respectively smeared on the inner side skin of the left wrist of a healthy human body after being pinched, each part of the product is smeared for three times, the painting is kept for 24 hours once, and the naked eye observation is carried out after 24 hours. No adverse phenomenon is generated in the third time, and the stimulation of the acupoint bead blasting type traditional Chinese medicine mask to healthy skin is preliminarily proved.
5.6 Performance testing of bead blasting mask on face acupoints
5.6.1 moisturizing Performance test
The masks of "examples 1, 2, 3", "comparative example 1 (application No. CN 201811203301.9)", and "comparative example 2 (commercially available)" were distributed to 100 subjects, the subjects were 18 to 50 years old, all were female, the subjects were divided into five groups of 20 persons each, and the same mask was used for each group of subjects. A subject draws a fixed area of 2 square centimeters on the forehead in an indoor environment with the temperature of 20 ℃ and the relative humidity of 50 percent respectively, uses a Corneometer CM285 skin moisture detector to test after using a mask on the fixed area, comprehensively obtains skin moisture change data, and calculates the water replenishing rate and the moisture preserving rate. Wherein the post-use, pre-use and post-1 hour humidity values are the average values for each group of subjects. The test results are shown in Table 6.
The water supplementing rate (%) is B/A × 100%
Moisture retention rate (%) C/B × 100%
Table 6 water replenishing and moisture keeping performance test result recording table
As a result: from the above test results, the data of the moisturizing rate and the moisturizing rate of "examples 1, 2, and 3" are larger than those of "comparative examples 1 and 2", so that it is demonstrated that the moisturizing and moisturizing effects of the mask of the present invention are significant.
5.6.2 whitening Performance test
The masks of "examples 1, 2, 3", "comparative example 1 (application No. CN 201811203301.9)", "comparative example 2 (commercially available)" were distributed to 100 subjects who were 18 to 50 years old, all women, and divided into five groups of 20 persons, each group of subjects used the same mask by acupoints every day for 30 days, and no other skin care product was used during the test period. The whitening effect of the facial mask is evaluated by measuring the melanin content of the facial skin (taking an average value) 1 day before use and 30 days after continuous use by using a MEXAMETER MX 16 skin pigment analyzer under the conditions that the ambient temperature is 25 +/-1 ℃ and the humidity is 50 +/-5%. The results of the melanin inhibition results are shown in table 7.
TABLE 7 test results of melanin inhibition
| Numbering | Sample (I) | Melanin inhibition ratio (%) |
| First group | Example 1 | 61.6 |
| Second group | Example 2 | 60.1 |
| Third group | Example 3 | 61.4 |
| Fourth group | Comparative example 1 | 48.3 |
| Fifth group | Comparative example 2 | 50.2 |
As a result: as can be seen from the above test results, the melanin inhibition ratio of "examples 1, 2, and 3" was higher than that of "comparative examples 1 and 2", and thus it was demonstrated that the whitening effect of the mask of the present invention was significant.
5.6.3 wrinkle reduction Performance test
The masks of "examples 1, 2, 3", "comparative example 1 (application No. CN 201811203301.9)", "comparative example 2 (commercially available)" were distributed to 100 subjects who were 18 to 50 years old, all women, and divided into five groups of 20 persons, each group of subjects used the same mask by acupoints every day for 30 days, and no other skin care product was used during the test period. Under the conditions that the ambient temperature is 25 +/-1 ℃ and the humidity is 50 +/-5%, a VISIA facial image analyzer is adopted for testing, smoothness data are comprehensively obtained, and the higher the data value is, the worse the skin smoothness is. The test results are shown in table 8, where the smoothness data are the average values for each group of subjects.
TABLE 8 skin smoothness Change Rate test results
| Numbering | Sample (I) | Before use | After use |
| First group | Example 1 | 2.4312 | 1.4213 |
| Second group | Example 2 | 2.4689 | 1.4539 |
| Third group | Example 3 | 2.5314 | 1.5210 |
| Fourth group | Comparative example 1 | 2.5132 | 2.0014 |
| Fifth group | Comparative example 2 | 2.4960 | 2.1036 |
As a result: as can be seen from the above test results, the skin smoothing rates of "examples 1, 2, and 3" are greatly different from those of "comparative examples 1 and 2", and thus it is demonstrated that the facial mask of the present invention has a remarkable wrinkle-removing effect.
5.6.4 acne removing Performance test
5.6.4.1 diagnostic criteria: clinically, patients with facial lesions such as papules, pustules, nodules, cysts and scars, with greasy facial skin, all adolescents with the above symptoms and middle-aged men and women are the criteria for selecting cases.
5.6.4.2 method of use: after the face is cleaned by warm water, the facial mask is applied to corresponding acupuncture points of the face, and is washed off after being kept for 20min, 3 times a week.
5.6.4.3 criteria for efficacy assessment:
and (3) healing: the symptoms completely disappeared;
the method has the following advantages: the symptoms are obviously improved or improved;
and (4) invalidation: no improvement in symptoms.
5.6.4.4 according to the above diagnostic criteria, the facial masks of "examples 1, 2 and 3", "comparative example 1 (application No. CN 201811203301.9)" and "comparative example 2 (commercially available)" were distributed to 100 subjects, the subjects were 18-50 years old, male and female were randomized, the subjects were divided into five groups of 20 subjects, each group of subjects was treated with the same facial mask on the acupuncture points, and the treatment effect was counted after 60 days of continuous use, and the results are shown in Table 9.
TABLE 9 statistical results of the acne-removing effect
As a result: as a result: from the above test results, it can be seen that the number of healing people and the number of ineffective people in examples 1, 2 and 3 are greater than those in comparative examples 1 and 2, and thus it is demonstrated that the facial mask of the present invention has a remarkable acne removing effect.
5.6.5 plaque reduction Performance test
The facial masks of "examples 1, 2 and 3", "comparative example 1 (application No. CN 201811203301.9)", and "comparative example 2 (commercially available)" were distributed to 100 subjects, the subjects were 18-50 years old, the subjects were randomized, the subjects were divided into five groups of 20 persons, each group of subjects was treated with the same facial mask on the acupoints, and the treatment effect was counted after 90 days of continuous use, and the results are shown in Table 10.
TABLE 10 statistical table of speckle reduction performance test results
As a result: from the above test results, it can be seen that the spot-fading effect of "examples 1, 2, and 3" is more remarkable than that of "comparative examples 1 and 2" after 3 months, thus showing that the spot-fading effect of the mask of the present invention is remarkable.
5.7 high temperature and Low temperature test
5g of the products obtained in the practical examples 1, 2 and 3 are respectively put into a centrifuge tube, placed in a constant-temperature water bath kettle at 100 ℃ and a refrigerator at-5 ℃ and-10 ℃, kept for 24h, and restored to room temperature for observation, and no obvious difference exists before and after the experiment.
5.8 mask stability Studies
The facial masks prepared by the methods of examples 1, 2 and 3 were respectively stored at room temperature for 3 months, 6 months, 12 months and 18 months, and the following quality stability tests were conducted.
5.8.1 examination of appearance and fineness
0.5g of each facial mask of the products of examples 1, 2 and 3 is taken, the facial masks are put into a test tube with the thickness of 10m L after being pinched and broken, the appearance characters of the facial masks are observed, a proper amount of finished products are taken and coated on the back of the hand, the fineness of the finished products is evaluated through sensory indexes, and the inspection results are shown in a table 11.
TABLE 11 table for the survey of appearance and fineness stability
As a result: according to the results in the table above, the appearance and the fineness of the facial mask are unchanged within 0-18 months, which indicates that the appearance and the fineness of the facial mask are relatively stable within 18 months.
pH value of 5.8.2
0.5g of each of the products of examples 1, 2 and 3 was kneaded, dissolved in L m of distilled water, kept at 40 ℃ for 30min, cooled to room temperature, and measured for pH shown in Table 12.
TABLE 12 table for pH stability
As a result: according to the results in the table, the pH value detection data of the facial mask is stable within 0-18 months, and the pH value detection data are all within 5.0-5.4, which indicates that the pH value of the facial mask is relatively stable within 18 months.
5.8.3 centrifugal experiment
At room temperature, 5g of the product of "examples 1, 2 and 3" was taken, kneaded, filled into a centrifuge tube of 10m L, placed in a centrifuge, and rotated at 1000, 2000, 3000, 4000 and 5000rpm for 10min, and the presence or absence of water in the sample was observed, and the results are shown in Table 13.
TABLE 13 Stable examination results of the centrifugation experiment
As a result: according to the results of the table above, no water analysis is found in the mask in 0-18 months of centrifugal test detection, and no layering phenomenon occurs, which indicates that the mask is relatively stable in 18 months of centrifugal test.
6. Conclusion of the research experiment
The invention researches an acupoint bead blasting type traditional Chinese medicine mask with the effects of moisturizing, whitening, removing wrinkles, lightening spots and removing acnes, and through experiments of a face moisturizing performance test, an acne removing performance test, a wrinkle removing performance test, a whitening performance test and a spot lightening performance test, the result of the invention is that all performance test data are superior to the comparative examples: the water-replenishing rate can reach more than 200%, the moisture-preserving rate can reach more than 90%, the melanin inhibition rate in the whitening performance test reaches 60%, and the acne-removing, spot-lightening and wrinkle-removing effects are obvious.
According to the invention, through stability test investigation, the appearance character and the fineness of the facial mask, the pH value and the centrifugal test are detected within 0 to 18 months, and the result shows that the facial mask has stable appearance character and fineness results, the pH value meets the requirement, and the centrifugal test has no water analysis and layering phenomenon; the facial mask has relatively stable quality in 0 to 18 months, and is suitable for industrial production.
Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. An acupoint bead-blasting traditional Chinese medicine mask is characterized by comprising the following raw materials: 3-7 parts of wormwood, 1-5 parts of ligusticum wallichii, 0.5-1.5 parts of safflower, 1-3 parts of tribulus terrestris, 1-3 parts of radix angelicae, 1-3 parts of rhizoma nardostachyos and 1-3 parts of white chrysanthemum.
2. The traditional Chinese medicine mask as claimed in claim 1, wherein the mask further comprises a pharmaceutically acceptable dosage form prepared from pharmaceutically acceptable excipients.
3. The traditional Chinese medicine mask as claimed in claim 2, wherein the auxiliary materials are: 1.5-2.5 parts of xanthan gum, 0.8-1.5 parts of sodium alginate, 0.5-2 parts of sodium carboxymethylcellulose and 20-30 parts of olive oil.
4. The traditional Chinese medicine mask as claimed in claim 3, which is prepared from the following raw and auxiliary materials: 3-7 parts of wormwood, 1-5 parts of ligusticum wallichii, 0.5-1.5 parts of safflower, 1-3 parts of tribulus terrestris, 1-3 parts of radix angelicae, 1-3 parts of rhizoma nardostachyos, 1-3 parts of white chrysanthemum, 1.5-2.5 parts of xanthan gum, 0.8-1.5 parts of sodium alginate, 0.5-2 parts of sodium carboxymethylcellulose and 20-30 parts of olive oil.
5. The traditional Chinese medicine mask as claimed in claim 4, which is prepared from the following raw and auxiliary materials: 5 parts of wormwood, 3 parts of ligusticum wallichii, 1 part of safflower, 2 parts of tribulus terrestris, 2 parts of radix angelicae, 2 parts of nardostachys chinensis, 2 parts of white chrysanthemum, 1.8-2.2 parts of xanthan gum, 1-1.2 parts of sodium alginate, 0.8-1.5 parts of sodium carboxymethylcellulose and 22-28 parts of olive oil.
6. The acupoint bead blasting type traditional Chinese medicine mask as claimed in claim 5, which is composed of the following raw and auxiliary materials: 5 parts of wormwood, 3 parts of ligusticum wallichii, 1 part of safflower, 2 parts of tribulus terrestris, 2 parts of angelica dahurica, 2 parts of nardostachys chinensis, 2 parts of white chrysanthemum, 2 parts of xanthan gum, 1.2 parts of sodium alginate, 1 part of sodium carboxymethylcellulose and 25 parts of olive oil.
7. The preparation method of the traditional Chinese medicine mask as claimed in any one of claims 1 to 6 is characterized by comprising the following steps:
1) adding 5-8 times of 40-60% methanol into the raw materials, extracting for 2-4 times, each time for 20-40 minutes, and filtering; pre-freezing the filtrate at-50 to-20 ℃ for 1.5 to 3 hours; controlling the thickness of the pre-frozen medicine to be 5-7 mm, and drying for 7-11 hours under the conditions that the pressure is 30-50 Pa and the temperature is 53-65 ℃ to obtain freeze-dried powder;
2) heating olive oil to 42-47 ℃, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and uniformly stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
8. The traditional Chinese medicine mask as claimed in claim 7, wherein the mask preparation method comprises:
1) extracting the raw materials with 7 times of 50% methanol for 3 times, each for 30min, and filtering; pre-freezing the filtrate at-35 deg.C for 2 h; controlling the thickness of the pre-frozen medicine at 6mm, and drying under the conditions of 40Pa and 60 ℃ for 9 hours to obtain lyophilized powder;
2) heating olive oil to 45 deg.C, sequentially adding xanthan gum, sodium alginate and sodium carboxymethylcellulose, and stirring;
3) uniformly stirring the freeze-dried powder and the auxiliary materials in the step 2), injecting the mixture into a pill dropping machine, preparing a mould with a pill making diameter of 3mm, and dropping the glue solution into the mould for pre-molding;
4) sending the mould into a dryer for drying and molding to obtain a finished product of the popping bead;
5) the bead blasting type traditional Chinese medicine facial mask is obtained by putting the bead blasting on non-woven fabric according to the position of the acupuncture point of the face, covering a layer of non-woven fabric on the bead blasting, and fixing the bead blasting.
9. The traditional Chinese medicine facial mask according to any one of claims 1 to 6, wherein the facial acupoints of the mask for bead blasting are Yingxiang, Er Men, Quanliao, Sibai, Jiache, Xiaguan, Yangbai, Chengjiang and Taiyang.
10. The traditional Chinese medicine facial mask according to any one of claims 1 to 6, which is characterized by application of the facial mask in moisturizing, whitening, wrinkle removal, speckle reduction and acne removal.
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| CN115252752A (en) * | 2022-07-20 | 2022-11-01 | 江西隆成医疗器械有限公司 | Acupoint stimulation paste essential oil blasting bead and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115252752A (en) * | 2022-07-20 | 2022-11-01 | 江西隆成医疗器械有限公司 | Acupoint stimulation paste essential oil blasting bead and preparation method and application thereof |
| CN115252752B (en) * | 2022-07-20 | 2023-11-28 | 江西隆成医疗器械有限公司 | Acupoint stimulation patch essential oil explosion bead, and preparation method and application thereof |
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