CN111658600B - Biological nursing lotion and preparation method thereof - Google Patents
Biological nursing lotion and preparation method thereof Download PDFInfo
- Publication number
- CN111658600B CN111658600B CN202010756063.5A CN202010756063A CN111658600B CN 111658600 B CN111658600 B CN 111658600B CN 202010756063 A CN202010756063 A CN 202010756063A CN 111658600 B CN111658600 B CN 111658600B
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- biological
- oligosaccharide
- percent
- lactobacillus
- lotion
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- 239000006210 lotion Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 230000000474 nursing effect Effects 0.000 title abstract description 31
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 62
- 241000186660 Lactobacillus Species 0.000 claims abstract description 25
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 23
- 239000000284 extract Substances 0.000 claims abstract description 22
- 239000002253 acid Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 19
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 19
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 19
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 19
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 18
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 18
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 18
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims abstract description 18
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims abstract description 17
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 16
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 16
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 16
- 229940107187 fructooligosaccharide Drugs 0.000 claims abstract description 16
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 16
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- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims abstract description 11
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- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 3
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Classifications
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- A61K8/42—Amides
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention relates to the field of nursing products, in particular to a biological nursing lotion suitable for women and a preparation method thereof. The biological care lotion consists of the following components: by mass percentage, 0.1-1% of sodium carboxymethyl cellulose, 3-6% of propylene glycol, 0.1-0.5% of caprylyl hydroximic acid, 0.1-0.5% of potassium sorbate, 10-55% of lactobacillus fermented extract, 2-6% of fructo-oligosaccharide, 2-6% of isomalto-oligosaccharide, 2-5% of sodium lauroyl sarcosinate, 1-5% of decyl glucoside, 0.1-0.5% of menthol and the balance of pure water. The biological nursing lotion has the identifying and sterilizing effects, can effectively kill harmful bacteria and does not harm beneficial bacteria, and has a certain repairing function on skin. The biological nursing lotion has the three-in-one effects of bacteriostasis, cleaning and nursing, has lasting and stable bacteriostasis performance, and is not easy to relapse of various inflammations.
Description
Technical Field
The invention relates to the field of nursing products, in particular to a biological nursing lotion suitable for women and a preparation method thereof.
Background
The "Xiao-character" washing lotion for women belongs to the category of disinfectants, and is a bacteriostatic agent which is used for women to clean, eliminate bad smell and treat gynecological inflammation so as to kill pathogenic microorganisms of pudendum and disinfect. The common female lotion in the market at present has various varieties, wherein the common antibacterial active ingredients comprise different antibacterial active ingredients, and the common antibacterial active ingredients comprise triclosan, chlorhexidine acetate, methyl hydroxybenzoate, silver ions, lysozyme and the like. However, these bacteriostatic active ingredients are not selective against bacterial and fungal kill, and therefore these products are called "general kill" bacteriostats.
If the general killing type bacteriostatic agent is used for a long time, the microecological balance of the vagina is broken, the lactobacillus and harmful bacteria are completely removed, and the vagina is in a sterile state. When the bacteriostatic agent is stopped, pathogenic bacteria invade the vagina again, and vagina inflammation also recurs.
In recent years, intensive research on female vaginal microbial flora has been carried out, and the results show that more than 70% of the microbial flora in the female vagina are lactobacillus which can effectively control the growth of harmful microorganisms and maintain the vaginal microecological balance. The lactobacilli can convert glycogen in the vagina into lactic acid, so that the whole vagina maintains a weak acid environment, and microorganisms which are easy to cause vagina inflammation, such as bacteria, mould, trichomonas and the like, can not tolerate a lower pH value like lactic acid bacteria, thereby achieving the purposes of killing and inhibiting harmful bacteria. Lactic acid bacteria also produce hydrogen peroxide, which has the effects of cleaning vagina and killing harmful bacteria. Thus, lactobacilli are also known as "health guards" for the vagina.
The Chinese invention patent CN103989623B discloses a functional female care lotion using probiotics and a preparation method thereof, and the functional female care lotion using the probiotics is prepared from the following raw materials: functional probiotics, anionic surfactant, nonionic surfactant, moisturizing and curing agent, 2.4.4-trichloro-2-hydroxydiphenyl ether, essential oil, essence and purified water. The probiotics are introduced through a specific formula proportion and a production process, and can play a role in inhibiting the growth of harmful bacteria; however, the activity of the probiotics gradually declines with the prolonging of the storage time, and the activity is easily influenced by the ambient temperature, so that the stability of the product is poor.
Disclosure of Invention
The biological care lotion can effectively inhibit harmful microorganisms, has lasting and stable antibacterial performance and has small influence on beneficial microorganisms; the biological nursing liquid provided by the invention is stable in performance and easy to preserve, and overcomes the defects of the existing product.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a biological care lotion, which comprises the following components: by mass percentage, 0.05-5% of sodium carboxymethyl cellulose, 1-10% of propylene glycol, 0.05-1.5% of organic acid, 0.05-1.5% of potassium sorbate, 5-60% of lactobacillus fermentation extract, 0.5-5% of sodium lauroyl sarcosinate, 0.1-5% of decyl glucoside, 0.01-1.0% of menthol and the balance of pure water.
Further, the biological care lotion further comprises the following components: calculated by mass percent, the prebiotics is 1 to 20 percent.
Further, the organic acid is caprylyl hydroximic acid, and the propylene glycol is 1, 2-propylene glycol.
The biological nursing lotion adopts novel, safe and non-irritant organic acid preservative, and the caprylyl hydroximic acid is organic acid and non-allergen component, has no carcinogenicity and teratogenicity, and can be biodegraded. The product can be used as chelating agent in cosmetics, and can effectively chelate iron ions, so that the growth of mould is limited in the environment lacking iron ions. The potassium sorbate belongs to organic acid preservatives, is internationally recognized low-toxicity and high-efficiency acid preservatives, and can effectively inhibit the activity of mould, microzyme and aerobic bacteria.
The invention adopts caprylyl hydroximic acid potassium sorbate as a main bacteriostatic component, and the combination of the caprylyl hydroximic acid potassium sorbate and the main bacteriostatic component can effectively inhibit the activities of respiratory enzymes and electron transfer enzyme systems in microbial cells, destroy the permeability of microbial membranes, and cause the leakage of proteins and ions in the intracellular parts, thereby achieving the effect of inhibiting and killing certain microbes. The antibacterial spectrum is characterized by strong action on aerobic pathogenic bacteria such as escherichia coli, staphylococcus aureus and candida albicans, and no or weak inhibition on anaerobic probiotics.
The biological nursing lotion is added with a lactobacillus fermentation extract, wherein the lactobacillus fermentation extract is a solution prepared by using skim milk powder as a main raw material and performing lactobacillus fermentation, separation, extraction, concentration and other operation processes. The solution contains lactic acid and bacteriocin, and has good antibacterial effect on harmful bacteria in vagina. Meanwhile, the skin care cream also contains amino acids, vitamin series, organic matters (alcohol, phenol, unsaturated fatty acid) and the like, and has an important effect on skin repair.
The biological nursing lotion is also added with prebiotics which have obvious nourishing and benefiting effects as a micro-ecological regulator. The addition of specific prebiotics further strengthens the dominance of the in-situ lactic acid bacteria.
Sodium lauroyl sarcosinate is an anionic surfactant, has excellent foamability, fine and durable foam, no stimulation to skin bodies and good washing/dispersing/emulsifying performance, and is the optimal choice for the surfactant in the formula of the nursing washing liquid. The alkyl glucoside is a nonionic surfactant prepared from natural renewable plants, has mild performance, good foamability, rich, fine and stable foam, good compatibility with skin, no irritation, and biodegradability. According to the invention, the sodium lauroyl sarcosinate and the alkyl glucoside are compounded and used to supplement each other, and the foam is rich, fine, stable and non-irritant.
The invention also provides a preparation method of the biological care lotion, which comprises the following steps:
s1, mixing part of deionized water and the lactobacillus fermentation extract, and stirring at the temperature of 30-40 ℃ and the rpm of 50-100 for 10-20min to obtain a mixture;
s2, sequentially adding fructo-oligosaccharide, isomaltooligosaccharide, sodium carboxymethyl cellulose, sodium lauroyl sarcosinate, alkyl glucoside, caprylyl hydroximic acid, potassium sorbate, propylene glycol and menthol into the mixture obtained in the step S1 under the condition of stirring, and keeping the temperature at 30-40 ℃;
and S3, after all the ingredients are dissolved, adding the rest deionized water, stirring, homogenizing, and standing to obtain a solution with the pH value of 5.2-5.6.
Compared with the prior art, the invention has the following advantages:
the biological nursing lotion has the identifying and sterilizing effects, can effectively kill harmful bacteria and does not harm beneficial bacteria, and has a certain repairing function on skin. The biological nursing lotion has rich, fine and stable foam, strong wetting power, no toxicity, no harm, no stimulation and quick biodegradation. The biological nursing lotion has the three-in-one effects of bacteriostasis, cleaning and nursing, has lasting and stable bacteriostasis performance, and is not easy to relapse of various inflammations.
The biological nursing lotion has simple components, stable performance and easy preservation, and the quality guarantee period can reach 24 months at normal temperature.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, and/or combinations thereof, unless the context clearly indicates otherwise.
In order to overcome the defects of the prior art, the invention provides a biological care lotion which comprises the following components, by mass, 0.05-5% of sodium carboxymethyl cellulose, 1-10% of propylene glycol, 0.05-1.5% of organic acid, 0.05-1.5% of potassium sorbate, 5-60% of a lactic acid bacteria fermentation extract, 0.5-5% of sodium lauroyl sarcosinate, 0.1-5% of decyl glucoside, 0.01-1.0% of menthol and the balance of pure water.
Preferably, the organic acid is caprylyl hydroxamic acid and the propylene glycol is 1, 2-propylene glycol.
Preferably, the bio-care lotion further comprises the following ingredients: the prebiotics are 1-20% by mass.
Further preferably, the prebiotics comprise one or more of fructo-oligosaccharide, isomalto-oligosaccharide, galacto-oligosaccharide, xylo-oligosaccharide, soybean oligosaccharide and inulin.
Even more preferably, the prebiotic consists of fructooligosaccharide and isomaltooligosaccharide. The fructo-oligosaccharide and isomalto-oligosaccharide are used in combination, the proliferation efficiency of the endogenous probiotics can reach 10-100 times higher, and the growth advantage of the vaginal pro-lactic acid bacteria can be effectively enhanced.
Preferably, the bio-care lotion consists of the following ingredients: by mass percentage, 0.1-1% of sodium carboxymethyl cellulose, 3-6% of propylene glycol, 0.1-0.5% of caprylyl hydroximic acid, 0.1-0.5% of potassium sorbate, 10-55% of lactobacillus fermented extract, 2-6% of fructo-oligosaccharide, 2-6% of isomaltooligosaccharide, 2-5% of sodium lauroyl sarcosinate, 1-5% of decyl glucoside, 0.1-0.5% of menthol and the balance of pure water.
Preferably, the preparation method of the lactobacillus fermentation extract comprises the following steps: (1) inoculating seed liquid of Lactobacillus rhamnosus, Lactobacillus plantarum and Lactobacillus acidophilus into a fermentation culture medium, and performing stationary culture at 37 deg.C for 20-24 hr; (2) pumping the fermentation liquid into a tubular centrifuge, and separating the solid and liquid components of the fermentation liquid under the conditions of 8000-10000 rpm; (3) and pumping the collected liquid part into a ceramic membrane filtering device with 100-150 nm for filtering to remove impurities, thus obtaining the product.
Preferably, the fermentation medium consists of: by mass percentage, 1-10% of skimmed milk powder, 0.1-5% of yeast extract powder and the balance of deionized water; sterilizing at 105 deg.C for 15-30 min.
Preferably, the pH of the wash liquor is between 5.2 and 5.6.
The invention also provides a preparation method of the biological care lotion, which comprises the following steps:
s1, mixing part of deionized water and the lactobacillus fermentation extract, and stirring at the temperature of 30-40 ℃ and the rpm of 50-100 for 10-20min to obtain a mixture;
s2, sequentially adding fructo-oligosaccharide, isomaltooligosaccharide, sodium carboxymethyl cellulose, sodium lauroyl sarcosinate, alkyl glucoside, caprylyl hydroximic acid, potassium sorbate, propylene glycol and menthol into the mixture obtained in the step S1 under the condition of stirring, and keeping the temperature at 30-40 ℃;
and S3, after all the ingredients are dissolved, adding the rest deionized water, stirring, homogenizing, and standing to obtain a solution with the pH value of 5.2-5.6.
Preferably, the temperature in steps S1, S2 is 37 ℃.
In order to make the technical solutions of the present invention more clearly understood by those skilled in the art, the technical solutions of the present invention will be described in detail below with reference to specific embodiments.
EXAMPLE 1A biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 0.3 percent of sodium carboxymethyl cellulose, 3 percent of 1, 2-propylene glycol, 0.2 percent of caprylyl hydroximic acid, 0.1 percent of potassium sorbate, 20 percent of lactobacillus fermentation extract, 2 percent of fructo-oligosaccharide, 2 percent of isomalto-oligosaccharide, 2 percent of sodium lauroyl sarcosine, 1 percent of alkyl glucoside, 0.1 percent of menthol and the balance of ultrapure water.
The lactic acid extract comprises the following components: the method comprises the following specific steps:
(1) preparing a seed solution: respectively inoculating strains of lactobacillus rhamnosus, lactobacillus plantarum and lactobacillus acidophilus to an MRS culture medium, and statically culturing at 37 deg.C for 18 h;
(2) and (3) fermenting and culturing lactic acid bacteria: inoculating the prepared seed liquid into a fermentation culture medium according to the inoculation amount of 2% of each bacterium, and performing static culture at 37 ℃ for 20-24 h;
the fermentation medium consists of the following components: 4 percent of skimmed milk powder, 0.6 percent of yeast extract powder and the balance of deionized water in percentage by mass; sterilizing at 105 deg.C for 15 min.
(3) And pumping the collected liquid part into a 100-nanometer ceramic membrane filtering device for filtering to remove impurities, thus obtaining the nano-composite ceramic membrane.
The preparation method of the biological care lotion comprises the following steps:
s1, adding part of ultrapure water and a lactobacillus fermentation extract into a stirring tank, stirring for 10-20min at the rotation speed of 50rpm, and controlling the temperature at 30-40 ℃;
s2, adding sodium carboxymethyl cellulose into S1, stirring for 20min at the rotation speed of 50rpm, and controlling the temperature at 37 ℃;
s3, adding fructo-oligosaccharide and isomaltose hypgather into S2, stirring for 20min under the condition that the rotation speed is 50rpm, and controlling the temperature at 37 ℃;
s4, adding sodium sarcosinate laurate and alkyl glucoside into S3, stirring for 10-20min under the condition that the rotation speed is 50rpm, and controlling the temperature at 37 ℃;
s5, adding capryl hydroximic acid and potassium sorbate into S4, stirring for 20min at the rotation speed of 50rpm, and controlling the temperature at 37 ℃;
s6, adding 1, 2-propylene glycol, menthol and residual ultrapure water into S5, stirring for 20min at the rotation speed of 50rpm, and controlling the temperature at 37 ℃;
s7, homogenizing the stock solution obtained in the step S6, and standing for later use, wherein the final pH of the obtained solution is 5.2-5.6.
And S8, detecting, filling, labeling, detecting and boxing the S7.
Through test detection, the female care lotion prepared in the embodiment has the health index, the bacteriostatic performance, the bacteriostatic stability, the skin allergy test, the vaginal mucosa irritation test and the cleaning power which all meet the requirements of national standards and regulations and also meet the property declaration of products.
The specific detection content and information are as follows:
(1) the nursing lotion provided by the embodiment 1 is detected to have bacteriostatic performance meeting the GB15979-2002 hygienic standard of disposable sanitary products and the requirements of the disinfection technical Specification (third edition). The detection result shows that the lotion has obvious bacteriostatic effect on common pathogenic bacteria such as escherichia coli, staphylococcus aureus and candida albicans in the vagina and meets the requirements of regulations. Has small inhibiting effect on common beneficial bacteria lactobacillus acidophilus in the vagina, and can not break the microecological balance in the vagina. The results are shown in table 1:
TABLE 1 results of the bacteriostatic properties test
(2) The nursing lotion provided by the embodiment 1 of the invention is accelerated at constant temperature and humidity, the acceleration period is 90 days at 37 ℃, the relative humidity is kept to be more than 75 percent, namely the relative humidity is converted into storage time of two years, and the antibacterial stability of the nursing lotion reaches the hygienic standard of GB15979-2002 disposable hygienic products and the requirement of 'disinfection technical specification' (third edition), thereby meeting the regulation requirement. The results are shown in table 2:
TABLE 2 results of the bacteriostatic stability test
(3) The nursing lotion provided by the embodiment 1 of the invention is detected to meet the requirements of disinfection technical specification (third edition) through skin allergy tests, the product is determined to be extremely light sensitization and meets the requirements of regulations, and the detection results are shown in Table 3:
TABLE 3 skin allergy test results
(4) Through detection, the vaginal mucosa irritation test of the nursing lotion provided by the embodiment 1 of the invention meets the requirements of disinfection technical specification (third edition), the product is clear to have no vaginal mucosa irritation and meets the requirements of regulations, and the detection result is shown in table 4:
TABLE 4 vaginal mucosa irritation test results
(5) The cleaning power of the inspection sample of the nursing lotion provided by the embodiment reaches the corresponding physicochemical index specified by the common adult shower gel (QB 1994 and 2013, bath lotion).
(6) Through detection, the pH value of the stock solution of the nursing lotion provided by the invention is 5.2-5.6 at 25 ℃, the stock solution accords with the proper pH value of female pudendum and genital tract, is beneficial to the growth of beneficial bacteria, and has good effect on maintaining and restoring local microecological balance.
Example 2A biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 1% of sodium carboxymethyl cellulose, 3% of propylene glycol, 0.1% of caprylyl hydroximic acid, 0.1% of potassium sorbate, 10% of lactobacillus fermentation extract, 2% of fructo-oligosaccharide, 2% of isomaltooligosaccharide, 2% of sodium lauroyl sarcosinate, 1% of decyl glucoside, 0.1% of menthol and the balance of ultrapure water.
The method for extracting lactic acid bacteria by fermentation and preparing the biological nursing lotion is the same as that described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 87.2 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 86.5 percent; the bacteriostasis rate of candida albicans (ATCC 10231) is as follows: 84.3 percent; the bacteriostasis rate of lactobacillus acidophilus (SDGL-01) is as follows: 6.2 percent.
EXAMPLE 3A biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 0.1% of sodium carboxymethyl cellulose, 6% of propylene glycol, 0.5% of caprylyl hydroximic acid, 0.5% of potassium sorbate, 55% of lactobacillus fermentation extract, 6% of fructo-oligosaccharide, 6% of isomalto-oligosaccharide, 5% of sodium lauroyl sarcosine, 5% of decyl glucoside, 0.5% of menthol and the balance of pure water.
The method for extracting lactic acid bacteria by fermentation and preparing the biological nursing lotion is the same as that described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 67.2 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 66.4 percent; the bacteriostasis rate of candida albicans (ATCC 10231) is as follows: 63.2 percent; the bacteriostasis rate of lactobacillus acidophilus (SDGL-01) is as follows: 6.7 percent.
EXAMPLE 4A biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 0.3 percent of sodium carboxymethyl cellulose, 3 percent of 1, 2-propylene glycol, 0.2 percent of caprylyl hydroximic acid, 0.1 percent of potassium sorbate, 20 percent of lactobacillus fermentation extract, 2 percent of sodium lauroyl sarcosinate, 1 percent of alkyl glucoside, 0.1 percent of mint ice, and the balance of ultrapure water.
The method of lactic acid bacteria fermentation extraction and the preparation of the biological care lotion are as described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 96.5 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 95.3 percent; the bacteriostasis rate of candida albicans (ATCC 10231) is as follows: 94.6 percent; the bacteriostasis rate of the lactobacillus acidophilus (SDGL-01) is as follows: 6.2 percent.
EXAMPLE 5A biological Care lotion
The biological care lotion consists of the following components: the high-purity sodium carboxymethyl cellulose is prepared from 0.05% of sodium carboxymethyl cellulose, 1% of propylene glycol, 0.05% of caprylyl hydroximic acid, 1.5% of potassium sorbate, 60% of lactobacillus fermented extract, 0.5% of sodium lauroyl sarcosinate, 0.1% of decyl glucoside, 0.01% of menthol and the balance of pure water.
The method for extracting lactic acid bacteria by fermentation and preparing the biological nursing lotion is the same as that described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 57.3 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 56.2 percent; the bacteriostatic rate of candida albicans (ATCC 10231) is as follows: 64.5 percent; the bacteriostasis rate of the lactobacillus acidophilus (SDGL-01) is as follows: 6.4 percent.
EXAMPLE 6A biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 5% of sodium carboxymethyl cellulose, 10% of propylene glycol, 1.5% of caprylyl hydroximic acid, 0.05% of potassium sorbate, 5% of lactobacillus fermentation extract, 4% of xylo-oligosaccharide, 5% of sodium lauroyl sarcosinate, 5% of decyl glucoside, 1.0% of menthol and the balance of pure water.
The method for extracting lactic acid bacteria by fermentation and preparing the biological nursing lotion is the same as that described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 82.5 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 80.2 percent; the bacteriostasis rate of candida albicans (ATCC 10231) is as follows: 88.5 percent; the bacteriostasis rate of lactobacillus acidophilus (SDGL-01) is as follows: 5.2 percent.
Comparative example 1 biological Care lotion
The biological care lotion consists of the following components: by mass percentage, 0.3 percent of sodium carboxymethyl cellulose, 3 percent of 1, 2-propylene glycol, 0.15 percent of chlorhexidine acetate, 20 percent of lactobacillus fermented extract, 2 percent of fructo-oligosaccharide, 2 percent of isomalto-oligosaccharide, 2 percent of sodium lauroyl sarcosine, 1 percent of alkyl glucoside, 0.1 percent of menthol and the balance of ultrapure water.
The method for extracting lactic acid bacteria by fermentation and preparing the biological nursing lotion is the same as that described in example 1.
When the bacteria inhibition is carried out for 10min, the bacteria inhibition rate of Escherichia coli (ATCC 25922) is as follows: 99.5 percent; the bacteriostatic rate of staphylococcus aureus (ATCC6538) was: 99.4 percent; the bacteriostasis rate of candida albicans (ATCC 10231) is as follows: 98.6 percent; the bacteriostasis rate of lactobacillus acidophilus (SDGL-01) is as follows: 99.8 percent.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (6)
1. A biological care lotion characterized in that it comprises the following ingredients: by mass percentage, 0.05-5% of sodium carboxymethylcellulose, 1-10% of propylene glycol, 0.05-1.5% of organic acid, 0.05-1.5% of potassium sorbate, 5-60% of lactobacillus fermentation extract, 0.5-5% of sodium lauroyl sarcosinate, 0.1-5% of decyl glucoside, 0.01-1.0% of menthol crystal and the balance of pure water;
also comprises prebiotics which are 1 to 20 percent by mass percent; the prebiotics comprise one or more of fructo-oligosaccharide, isomaltooligosaccharide, galacto-oligosaccharide, xylo-oligosaccharide, soybean oligosaccharide and inulin;
the organic acid is caprylyl hydroximic acid, and the propylene glycol is 1, 2-propylene glycol;
the preparation method of the lactobacillus fermentation extract comprises the following steps:
(1) inoculating seed liquid of Lactobacillus rhamnosus, Lactobacillus plantarum and Lactobacillus acidophilus into fermentation culture medium, and standing at 37 deg.C for 20-24 hr;
(2) pumping the fermentation liquid into a tubular centrifuge, and separating the solid and liquid components of the fermentation liquid under the conditions of 8000-10000 rpm;
(3) pumping the collected liquid part into a ceramic membrane filtering device with 100-150 nm for filtering to remove impurities, thus obtaining the product;
the fermentation medium consists of the following components: by mass percentage, 1-10% of skimmed milk powder, 0.1-5% of yeast extract powder and the balance of deionized water; sterilizing at 105 deg.C for 15-30 min.
2. The bio-care lotion according to claim 1, wherein the prebiotic is comprised of fructooligosaccharide and isomaltooligosaccharide.
3. The bio-care lotion according to claim 1, consisting of: by mass percentage, 0.1-1% of sodium carboxymethylcellulose, 3-6% of propylene glycol, 0.1-0.5% of caprylyl hydroximic acid, 0.1-0.5% of potassium sorbate, 10-55% of lactobacillus fermentation extract, 2-6% of fructo-oligosaccharide, 2-6% of isomaltooligosaccharide, 2-5% of sodium lauroyl sarcosinate, 1-5% of decyl glucoside, 0.1-0.5% of menthol and the balance of pure water.
4. A biological care lotion according to any of claims 1 to 3, characterized in that the lotion has a pH of 5.2 to 5.6.
5. A method of making a biological care lotion according to any of claims 1 to 3 comprising the steps of:
s1, mixing part of deionized water and the lactobacillus fermentation extract, and stirring at the temperature of 30-90 ℃ and the rpm of 50-100 for 10-20min to obtain a mixture;
s2, sequentially adding fructo-oligosaccharide, isomaltooligosaccharide, sodium carboxymethylcellulose, sodium lauroyl sarcosinate, decyl glucoside, caprylyl hydroximic acid, potassium sorbate, propylene glycol and menthol into the mixture obtained in the step S1 under stirring, and keeping the temperature at 30-90 ℃;
and S3, after all the ingredients are dissolved, adding the rest deionized water, stirring, homogenizing, and standing to obtain a solution with the pH value of 5.2-5.6.
6. The method of claim 5, wherein the temperature in steps S1 and S2 is 37 ℃.
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| CN202010756063.5A Active CN111658600B (en) | 2020-07-31 | 2020-07-31 | Biological nursing lotion and preparation method thereof |
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| CN103989623B (en) * | 2014-06-13 | 2016-08-24 | 云南白药清逸堂实业有限公司 | A kind of functional Feminine care lotion applying probiotic bacteria and preparation method |
| KR20170074043A (en) * | 2015-12-21 | 2017-06-29 | 한방약초힐링 농업회사법인주식회사 | Cleanser for women's vagina and method for manufacturing the same |
| CN106580791B (en) * | 2016-12-23 | 2020-06-09 | 广州睿森生物科技有限公司 | Antibacterial composition and private care product |
| KR20190042164A (en) * | 2017-10-16 | 2019-04-24 | (주)몽드드 | Composition and method for non-atiseptic wet tissues containing the ingredient to inhibit microbial propagation |
| CN109044928A (en) * | 2018-09-05 | 2018-12-21 | 广州丽彦妆生物科技有限公司 | A kind of secret nursing bacteriostatic gel and preparation method thereof |
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