CN101564519A - External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof - Google Patents
External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof Download PDFInfo
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- CN101564519A CN101564519A CNA2009100670676A CN200910067067A CN101564519A CN 101564519 A CN101564519 A CN 101564519A CN A2009100670676 A CNA2009100670676 A CN A2009100670676A CN 200910067067 A CN200910067067 A CN 200910067067A CN 101564519 A CN101564519 A CN 101564519A
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Abstract
The invention discloses an external medicine for treating the parasitic infection, fungal infection and bacterial infection of pets, which is prepared by processing radix stemonae, dittany bark, common cnidium fruits, belvedere fruits, red paeony roots, Japanese honeysuckle stems, lightyellow sophora roots, rhizoma coptidis, sulfur and mint. The external medicine can effectively and safely resist mites, lice, fleas, ticks and other parasites, and has the functions of resisting fungal infection and bacterial infection.
Description
Technical field:
The present invention relates to a kind of herbal medicine and preparation method thereof, particularly a kind of topical agent for the treatment of house pet parasite, fungus, bacterial infection and preparation method thereof belongs to traditional Chinese medical science veterinary drug technical field.
Background technology
The house pet parasitic disease is one of house pet common disease, and the clinical onset rate accounts for dermopathic demodicidosis, acaricide, otoacariasis, pediculosis, pulicosis, the ixodes infestation etc. of mainly containing more than 60%.Already endanger very greatly to supporting dog, not only influence the normal breeding of dog and produce, and influence the use value of dog.In addition, but parasite also secondary fungus, bacterial infection, and these parasites, fungus, bacterial infection can infect the people, and human health is caused potential threat.
Dog adopts ivermectin to treat more in treatment, and consumption is every kg body weight 0.05-0.1 milligram, at interval 7-10 days repeated drug takings once, how this amount medication causes Canis familiaris L. to poison.Occur after the poisoning that lethargy appetite is useless exhausted, myasthenia of limbs, back acroparalysis, the general paralysis that has is breathed, palpitating speed is dead because of heart failure at last.The therapeutic dose of ivermectin and toxic dose are good at approaching, if consumption surpasses three times of therapeutic dose, can be poisoned to death.If at a distance of too near, also may causing to overstock, double injection poisons.In addition, because that ivermectin absorbs is slow, common the 3rd talent responds, the poisoning sign: useless exhausted, the dyspnea of depressed, the unable paralysis of spirit, palpitating speed, serious appetite, if untimely rescue, and can be dead because of heart failure.The excessive poisoning symptom of ivermectin is as follows: Canis familiaris L. spirit is depressed, back acroparalysis, and heart failure appears in the dyspnea of palpitating quickly, but body temperature is still normal.Conceived bitch Canis familiaris L. can not be used ivermectin and derivant thereof, causes miscarriage and stillborn fetus easily, uses ivermectin can not breed in half a year at least, causes empty pregnant easily.Other drug such as decis, Amitraz, organophosphor medicine etc. are all to the house pet toxic side effect.
Summary of the invention
The object of the invention provides a kind of topical agent for the treatment of house pet parasite, fungus, bacterial infection, parasitic medicines such as antimite, louse, flea, Ticks safely and effectively, and the effect of antifungal, bacterial infection is arranged.
The invention also discloses manufacturing method for above mentioned medicine, be suitable for suitability for industrialized production.
The present invention treats the topical agent of house pet parasite, fungus, bacterial infection, is made by following parts of medicines by weight:
Radix Stemonae 100-500 weight portion, Cortex Dictamni 100-500 weight portion, Fructus Cnidii 100-500 weight portion, Fructus Kochiae 100-500 weight portion, Radix Paeoniae Rubra 100-500 weight portion, Caulis Lonicerae 100-500 weight portion, Radix Sophorae Flavescentis 100-300 weight portion, Rhizoma Coptidis 100-300 weight portion, sulfur 100-300 weight portion, Herba Menthae 100-500 weight portion.
The aforementioned pharmaceutical compositions preferred group becomes:
The Radix Stemonae 300 weight portions, Cortex Dictamni 300 weight portions, Fructus Cnidii 200 weight portions, the Fructus Kochiae 200 weight portions, Radix Paeoniae Rubra 200 weight portions, Caulis Lonicerae 200 weight portions, Radix Sophorae Flavescentis 100 weight portions, Rhizoma Coptidis 100 weight portions, sulfur 100 weight portions, Herba Menthae 200 weight portions.
The aforementioned pharmaceutical compositions preferred group becomes:
The Radix Stemonae 400 weight portions, Cortex Dictamni 200 weight portions, Fructus Cnidii 300 weight portions, the Fructus Kochiae 100 weight portions, Radix Paeoniae Rubra 100 weight portions, Caulis Lonicerae 100 weight portions, Radix Sophorae Flavescentis 200 weight portions, Rhizoma Coptidis 200 weight portions, sulfur 100 weight portions, Herba Menthae 100 weight portions.
Process for preparing medicine of the present invention may further comprise the steps: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 6-10 and doubly measure the 60%-95% alcohol reflux 1-3 time, each 1-3h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure 40%-70%, add the sulfur fine powder to final volume, dissolving, filter, add acceptable clinically all the other adjuvants such as surfactant, permeation-promoter, distilled water etc., make solution.
Medicine spray preparation method of the present invention is as follows: above ten flavors, it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 75% alcohol refluxs 3 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 60% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% propylene glycol, distilled water again and adds to 10000ml, spray is made in fill.
Inuncts process for preparing medicine of the present invention is characterized in that this method is: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 95% alcohol refluxs 2 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 40% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% glycerol, distilled water again and adds to 10000ml, inuncts are made in fill.
The medical effect of following clinical practice proof pharmaceutical preparation of the present invention:
Example 1
Suffer from dog head portion, the bridge of the nose, eye socket, ear and skin of chest be rubescent the brief summary of rash shape, and there are a large amount of wheat bran shape scurfs on the surface, pachyderma, by hair come off, surface coverage crust, be full of cracks.Sick dog play is itched, and scratches with hind leg frequently, and friction has skin to scratch or crust breaks, and hemorrhage, affected part can have purulent secretion, and frowziness.Be diagnosed as mite infection.
Treatment: earlier with dermatitis curative, treatments such as 886, no positive effect selects for use medicine of the present invention to treat, and logotype three days suffers from dog skin skin crust all to come off, and the petechia disappears, and skin recovers normally.
Example 2
The little honored guest girl of black, there is the bald spot of the circle of a black at the back, does not take notice of at the beginning, think it is burning hot, the coming off of black after having a bath afterwards just seen the little kitchen that is originally many clearly, the Rhizoma Imperatae that can indistinctly see. made a definite diagnosis to hospital afterwards, say so acarid and fungus mixed infection have been played antiinflammatory and have been killed demodicid mite, also have the pin of skin nutrition, 5 pins have been played once, opened the medicine that external is smeared, result, the 2nd day slight redness of discovery.So inquire by telephone the doctor, say so and will then beat, slowly nurse one's health, the general meaning is, and pin can not break, and 5 days one courses of treatment, the result does not still feel any better.Adopt medicine of the present invention to embrocate treatment, one day twice, logotype three days, result's recovery from illness.
Example 3
Scotland shepherd dog, find before two wheat harvesting periods that it got acarid (it is just the same that symptom and I see) on data, thing as dandruff is arranged a lot, whole body all overgrows with, a lot of veterinarys have been asked, as if it is pretty troublesome to say that all this Canis familiaris L. got acarid, can not beat ivermectin, do not have medicine to cure at all.
Treatment: select for use medicine of the present invention to carry out whole body and embrocate treatment, logotype five days is suffered from dog skin skin scurf and is all disappeared, and it is normal that skin recovers.
Good effect of the present invention is: adopt Chinese medicines such as the Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae and sulfur, the pure Chinese medicinal preparation for preparing a kind of energy parasiticide, fungus, bacterial infection, be characterized in having no side effect, the wide spectrum specially good effect, effect is lasting, easy to use, clinical symptom disappearance is rapid, and no rebound phenomena takes place.Be used for the treatment of the sarcoptes canis disease, otodectic mange, the type of wriggling acariasis louse infects disease, fungus dermatitis, eczema, dermatitis, acute and chronic dermatosiss such as skin wire-like bacteria, to the leprosy of house pet, skin infectious disease such as tinea have special efficacy, simultaneously endoparasite and ectoparasite are also killed effect.
The specific embodiment:
Below in conjunction with embodiment, to as follows according to the specific embodiment provided by the invention:
Embodiment 1
Take by weighing by weight: Radix Stemonae 300g, Cortex Dictamni 300g, Fructus Cnidii 200g, Fructus Kochiae 200g, Radix Paeoniae Rubra 200g, Caulis Lonicerae 200g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 100g, sulfur 100g, Herba Menthae 200g.
Described process for preparing medicine is as follows: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 75% alcohol refluxs 3 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 60% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% propylene glycol, distilled water again and adds to full dose 10000ml, spray is made in fill.
Embodiment 2
Take by weighing by weight: Radix Stemonae 400g, Cortex Dictamni 200g, Fructus Cnidii 300g, Fructus Kochiae 100g, Radix Paeoniae Rubra 100g, Caulis Lonicerae 100g, Radix Sophorae Flavescentis 200g, Rhizoma Coptidis 200g, sulfur 100g, Herba Menthae 100g.
Described process for preparing medicine is as follows: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 95% alcohol refluxs 2 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 40% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% glycerol, distilled water again and adds to full dose 10000ml, inuncts are made in fill.
Embodiment 3
Take by weighing Radix Stemonae 500g, Cortex Dictamni 200g, Fructus Cnidii 500g, Fructus Kochiae 300g, Radix Paeoniae Rubra 400g, Caulis Lonicerae 300g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 250g, sulfur 200g, Herba Menthae 200g.More than ten the flavor, it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 75% alcohol refluxs 2 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 50% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% glycerol, distilled water again and adds to full dose 10000ml, solution is made in fill.
Claims (6)
1, a kind of topical agent for the treatment of house pet parasite, fungus, bacterial infection, make by following parts of medicines by weight:
Radix Stemonae 100-500, Cortex Dictamni 100-500, Fructus Cnidii 100-500, Fructus Kochiae 100-500, Radix Paeoniae Rubra 100-500, Caulis Lonicerae 100-500, Radix Sophorae Flavescentis 100-300, Rhizoma Coptidis 100-300, sulfur 100-300, Herba Menthae 100-500.
2, the described pharmaceutical composition of claim 1, preferred group becomes:
The Radix Stemonae 300, Cortex Dictamni 300, Fructus Cnidii 200, the Fructus Kochiae 200, Radix Paeoniae Rubra 200, Caulis Lonicerae 200, Radix Sophorae Flavescentis 100, Rhizoma Coptidis 100, sulfur 100, Herba Menthae 200.
3, the described pharmaceutical composition of claim 1, preferred group becomes:
The Radix Stemonae 400, Cortex Dictamni 200, Fructus Cnidii 300, the Fructus Kochiae 100, Radix Paeoniae Rubra 100, Caulis Lonicerae 100, Radix Sophorae Flavescentis 200, Rhizoma Coptidis 200, sulfur 100, Herba Menthae 100.
4, the preparation method of claim 1 or 2 or 3 described medicines may further comprise the steps: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 6-10 and doubly measure the 60%-95% alcohol reflux 1-3 time, each 1-3h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure 40%-70%, add the sulfur fine powder to final volume, dissolving, filter, add acceptable clinically all the other adjuvants such as surfactant, permeation-promoter, distilled water, make solution.
5, the spray preparation method of claim 1 or 2 or 3 described medicines may further comprise the steps: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 75% alcohol refluxs 3 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 60% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% propylene glycol, distilled water again and adds to 10000ml, spray is made in fill.
6, the inuncts preparation method of claim 1 or 2 or 3 described medicines may further comprise the steps: above ten flavors, and it is standby that Cosan is broken into fine powder; The Radix Stemonae, Cortex Dictamni, Fructus Cnidii, the Fructus Kochiae, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Menthae add 8 times of amount 95% alcohol refluxs 2 times, each 1h, merge alcohol reflux liquid, reclaim ethanol, make to contain alcohol and measure to 40% of final volume, add the sulfur fine powder, dissolving is filtered, and adds 2% Tween 80,5% dimethyl sulfoxide, 10% glycerol, distilled water again and adds to 10000ml, inuncts are made in fill.
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