CN108785212A - A kind of Chinese herbal compounds and its application with antibacterial and anti-mite - Google Patents

A kind of Chinese herbal compounds and its application with antibacterial and anti-mite Download PDF

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Publication number
CN108785212A
CN108785212A CN201811060201.5A CN201811060201A CN108785212A CN 108785212 A CN108785212 A CN 108785212A CN 201811060201 A CN201811060201 A CN 201811060201A CN 108785212 A CN108785212 A CN 108785212A
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chinese herbal
antibacterial
mite
herbal compounds
chinese
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CN108785212B (en
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孔令姗
吴震
郑雄健
谢振荣
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Shanghai Lanhai Biotechnology Co Ltd
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Shanghai Lanhai Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/51—Gentianaceae (Gentian family)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
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    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants

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Abstract

The invention discloses a kind of Chinese herbal compounds with antibacterial and anti-mite, the active constituents of the Chinese herbal compounds by Cnidium Monnieri, felwort, kuh-seng, the leaf of bamboo, Chinese herbaceous peony, myrrh, Radix Glycyrrhizae, Cortex Phellodendri, the root bark of shaggy-fruited dittany, Fructus Forsythiae, the tuber of stemona, caulis lonicerae, sophora flower is compound is prepared.Chinese herbal compounds provided by the invention can be used for washing in shield product, have the effect of antibacterial, sterilization, anti-inflammatory, anti-mite.

Description

A kind of Chinese herbal compounds and its application with antibacterial and anti-mite
Technical field
The invention belongs to Chinese medicine and daily chemicals field more particularly to a kind of Chinese herbal compounds with antibacterial and anti-mite and its answer With.
Background technology
With the continuous improvement of people's living standard and health perception, to the knowledge used in everyday for washing shield product and requirement Also it is being continuously improved and is extending.It is known that it is parasitic on human body or be infected with a large amount of dirts such as bacterium and acarid, it gives People's health causes different degrees of loss and injury.Acarid is generally 0.1-0.2 millimeters long, and type is various, and wherein human body is compacted Shape mite is the higher a kind of parasite of infection rate in crowd, in parasitic and hair follicle and sebaceous glands, with cell liquid and smegma Grease be nutriment, effect is damaged to the skin histology of host, pruitus, small papule etc., severe one occurs in less serious case Lead to acne rosacea, epifolliculitis, seborrhea and acne.
That often sells on the market at present washes shield product, such as：Anti- mite cosmetics, body cleansing products, cleaning products, women Care product etc., active ingredient is mainly based on chemical reagent finished product.
Invention content
For above-mentioned technical problem in the prior art, the present invention provides a kind of Chinese medicine with antibacterial and anti-mite is compound Object and its application, this Chinese herbal compounds and its application will solve antimite product antimite effect in the prior art Bad technical problem.
The present invention provides a kind of Chinese herbal compounds with antibacterial and anti-mite, the active constituents of the Chinese herbal compounds by Cnidium Monnieri, felwort, kuh-seng, the leaf of bamboo, Chinese herbaceous peony, myrrh, Radix Glycyrrhizae, Cortex Phellodendri, the root bark of shaggy-fruited dittany, Fructus Forsythiae, the tuber of stemona, caulis lonicerae, sophora flower It is compound to be prepared.
Further, the active constituent of the Chinese herbal compounds is prepared by the raw material of following weight percent：
Frutus cnidii 1-20%,
Felwort 1-20%,
Kuh-seng 1-20%,
Leaf of bamboo 1-20%,
Chinese herbaceous peony 1-20%,
Myrrh 1-20%,
Radix Glycyrrhizae 0.5-10%,
Cortex Phellodendri 0.5-10%,
Root bark of shaggy-fruited dittany 0.5-10%,
Fructus Forsythiae 0.5-10%,
Tuber of stemona 0.5-10%,
Caulis lonicerae 0.5-10%
Sophora flower 0.5-10%.
Further, a kind of active constituent of Chinese herbal compounds with antibacterial and anti-mite is by following weight percent Raw material be prepared：
Frutus cnidii 13-18%,
Felwort 11-16%,
Kuh-seng 7-12%,
Leaf of bamboo 5-10%,
Chinese herbaceous peony 10-15%,
Myrrh 9-14%,
Radix Glycyrrhizae 3-8%,
Cortex Phellodendri 3-8%,
Root bark of shaggy-fruited dittany 2-7%,
Fructus Forsythiae 1-6%,
Tuber of stemona 3-8%,
Caulis lonicerae 1-6%,
Sophora flower 2-7%.
Further, a kind of active constituent of Chinese herbal compounds with antibacterial and anti-mite is by following weight percent Raw material be prepared：
Frutus cnidii 15%,
Felwort 15%,
Kuh-seng 7%,
The leaf of bamboo 7%,
Chinese herbaceous peony 11%,
Myrrh 11%,
Radix Glycyrrhizae 6%,
Cortex Phellodendri 6%,
The root bark of shaggy-fruited dittany 6%,
Fructus Forsythiae 6%,
The tuber of stemona 4%,
Caulis lonicerae 4%,
Sophora flower 2%.
Further, a kind of active constituent of Chinese herbal compounds with antibacterial and anti-mite is by following weight percent Raw material be prepared：
Frutus cnidii 20%,
Felwort 15%,
Kuh-seng 12%,
The leaf of bamboo 11%；
Chinese herbaceous peony 9%,
Myrrh 8%,
Radix Glycyrrhizae 8%,
Cortex Phellodendri 6%,
The root bark of shaggy-fruited dittany 6%,
Fructus Forsythiae 2%,
The tuber of stemona 2%,
Caulis lonicerae 0.5%,
Sophora flower 0.5%.
The present invention also provides a kind of above-mentioned Chinese herbal compounds with antibacterial and anti-mite prepare it is antibacterial, sterilize, disappear Application in the product of scorching or anti-mite.
The present invention also provides one kind washing shield product, contains a kind of above-mentioned Chinese herbal compounds with antibacterial and anti-mite.
Further, the mass percent concentration of the Chinese herbal compounds is 0.5 ~ 5%.
The present invention also provides a kind of face creams, it is characterised in that：Contain a kind of above-mentioned Chinese medicine with antibacterial and anti-mite Compound.
Further, the mass percent concentration of the Chinese herbal compounds is 0.5 ~ 5%.
In the raw material that the present invention selects：
Frutus cnidii is the dry mature fruit of samphire cnidium monnieri, there is eliminating dampness, wind-dispelling, the effect of desinsection, for treating sun Impotence, Gong Leng, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the back；Control eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis outside.
Felwort, Gentianaceae, Gentiana perennial herb, rhizome lies down or upright, most sturdy, slightly meat the palpuses of tool Root.Branch Dan Sheng, uprightly, yellow green or aubergine, hollow, subcircular have a rib, have mastoid process on rib, dilute smooth.It is wet for treating Hot jaundice, urine leaching pain, swelling of vulva pruritus vulvae, humid tropics are inferior.
Kuh-seng is the dry root of legume kuh-seng, bitter, trembles with fear, there is the effect of heat-clearing and damp-drying drug, desinsection, diuresis；It can be used for controlling Treatment hot dysentery, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy control trichomonas vaginitis outside.
The leaf of bamboo is the leaf of grass henon bamboo.It with clearing heat and relieving fidgetness, promotes the production of body fluid, the effect of diuresis.It is tired for treating pyreticosis Yearningly, pediatric epilepsy scared, cough is against hematemesis, scanty drak urine, aphthous stomatitis tongue boil.
Chinese herbaceous peony is Paeoniaceae Paeonia Chinese herbaceous peony group perennial herb, has antispastic, analgesia, promoting menstruation effect；To the abdomen of women Bitterly, the illnesss such as gastrospasm, dizziness, gout, diuresis are effective.
Myrrh is olive subject plant Chinese violet tree or the dry resin of Ha Didingshu.It is divided into natural myrrh and gum opoponax.Point It is distributed in the ground such as Somalia, Ethiopia and Arabia Peninsula south.With scattered stasis pain, the effect of detumescence and promoting granulation.It is usually used in Chest impediment and cardialgia, arthralgia pain due to rheumatism, traumatic injury, the treatment of the illnesss such as carbuncle swells sore.
Radix Glycyrrhizae is pulse family, Glycyrrhiza perennial herb, and root is sturdy with root-like stock, is a kind of help Chinese herbal medicine, can treat Clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..
In addition, Cortex Phellodendri, the root bark of shaggy-fruited dittany, Fructus Forsythiae, the tuber of stemona, caulis lonicerae, sophora flower also have heat-clearing and damp-drying drug, purging intense heat, detoxification sore treatment etc. Effect.
A kind of Chinese herbal compounds with antibacterial and anti-mite provided by the invention, have preferable antibacterial, sterilization, anti-inflammatory, Control for Varroa, Chinese herbal compounds combination China's traditional Chinese medicine ingredients and theory, it is safe, it is easy to use, it is applied daily Wash shield product in, have significant effect and preferable foreground.
The present invention is compared with prior art, and technological progress is significant.The present invention provides one kind have it is antibacterial, kill Bacterium, anti-inflammatory and anti-mite have the Chinese herbal compounds of positive effect, safe using China traditional traditional Chinese medicine ingredients and theory, With preferable application value and meaning.And the antimite time is short, effect is good, can be applied to daily wash in shield product.
With reference to specific embodiment, the invention will be further described.
Specific implementation mode
It can be with the present invention will be further elaborated by the following examples, it is clear that the scope of the present invention not office It is limited to following embodiments.Based on the embodiments of the present invention, relevant technical staff in the field is not departing from the content of present invention, essence Method described herein and application are modified or are suitably changed and combined in god and range, belongs to the protection model of the present invention It encloses.
The present invention carries out general and/or concrete description to the raw material and experimental method that are arrived used in experiment, uses To many materials and operating method be known in the art, be described in detail as far as possible in the present invention；Used Chinese medicine material It is provided for our company and/or market product purchasing.
Embodiment 1：Chinese herbal compounds
A kind of active constituent of the Chinese herbal compounds with antibacterial and anti-mite is prepared by the raw material of following weight percent：Snake Machine tool 20%, felwort 15%, kuh-seng 12%, the leaf of bamboo 11%；Chinese herbaceous peony 9%, myrrh 8%, Radix Glycyrrhizae 8%, Cortex Phellodendri 6%, the root bark of shaggy-fruited dittany 6%, even Stick up 2%, the tuber of stemona 2%, caulis lonicerae 0.5%, sophora flower 0.5%.
The preparation method of the Chinese herbal compounds of the present embodiment is：By above-mentioned weight percent, Chinese medicine is weighed, by feed liquid matter Measure ratio 1:10 are added volume fraction carries out reflux extraction, about 3h for 50~90% ethyl alcohol, and filtering settles overnight, granular activated carbon 60 DEG C processing 2h, diatomite filtration treatment, centrifugation, feed liquid low temperature is concentrated into medicinal extract, the as Chinese herbal compounds of the present embodiment.
Embodiment 2：Chinese herbal compounds
A kind of active constituent of the Chinese herbal compounds with antibacterial and anti-mite is prepared by the raw material of following weight percent：Snake Machine tool 15%, felwort 15%, kuh-seng 7%, the leaf of bamboo 7%；Chinese herbaceous peony 11%, myrrh 11%, Radix Glycyrrhizae 6%, Cortex Phellodendri 6%, the root bark of shaggy-fruited dittany 6%, even Stick up 6%, the tuber of stemona 4%, caulis lonicerae 4%, sophora flower 2%.
The preparation method of the Chinese herbal compounds of the present embodiment is：By above-mentioned weight percent, Chinese medicine is weighed, by feed liquid matter Measure ratio 1:10 are added volume fraction carries out reflux extraction, about 3h for 50~90% ethyl alcohol, and filtering settles overnight, granular activated carbon 60 DEG C processing 2h, diatomite filtration treatment, centrifugation, feed liquid low temperature is concentrated into medicinal extract, the as Chinese herbal compounds of the present embodiment.
Embodiment 3：Chinese herbal compounds application
The Chinese herbal compounds medicinal extract prepared in embodiment 1 is weighed, glycerine-water as solvent is added（The mass ratio of glycerol and water is 4: 1）, the dissolving of 85 DEG C of heating stirrings obtains mixed solution, and the mass percent concentration of the mixed solution is 5%, stirring cooling To 50 DEG C, it is added 0.02%（For the mass percent concentration of above-mentioned mixed solution）Chelating agent disodium ethylene diamine tetraacetate and 0.05% （For the mass percent concentration of above-mentioned mixed solution）Antioxidant BHT obtains Chinese herbal compounds product liquid.
Embodiment 4：Anti-microbial property test
Chinese herbal compounds product liquid（Using embodiment 3）Antibacterial ability test with reference to QB/T 2738-2012《Daily chemical products The evaluation method of antibacterial bacteriostatic effect》The fungistatic effect method of inspection of -7.3 antibacterial type daily chemical products（Suspension quantitative method）It carries out, Activity is 1:1 and 1:1000, action time 5min, the experimental results showed that, product is to Candida albicans（ATCC 10231） And staphylococcus aureus（ATCC 6538）Sterilization and fungistatic effect are as shown in the following table 1 and 2.
Table 1：Chinese herbal compounds product liquid bactericidal effect test result
Table 2：Chinese herbal compounds product liquid fungistatic effect test result
Embodiment 4：Mite resistance can be tested
The Chinese herbal compounds of embodiment 1 are added in basic face cream, the face containing 0.5%, 2% and 5% Chinese herbal compounds is configured to Frost carries out external resistance test to vermiform mite.Polypide and the face cream containing Chinese herbal compounds are mixed well, 37 DEG C of incubators are placed in Glass slide is taken out in interior incubation, timing, and microscopically observation records polypide activity condition, with the gnathosoma of acarid, four pairs of foots and opisthosoma Standard of the without motion as acarid dead；Control group is face cream and 10% sulfur ointment without Chinese herbal compounds.Experimental result As shown in table 3.
This laboratory reference document：The effect of Li Jianhua, the beautiful folium eucalyptis bloom of Zhou Minjun, Qiu Xue anti-vermiform mite, is observed [J] China Amphixenosis's magazine, 2001,17（3）.
Table 3：Chinese herbal compounds face cream anti-vermiform mite effect in vitro
By above-described embodiment it is found that Chinese herbal compounds provided by the invention have good antibacterial, antibacterial, anti-mite effect, can use Shield product is washed in daily.

Claims (10)

1. a kind of Chinese herbal compounds with antibacterial and anti-mite, it is characterised in that：The active constituent of the Chinese herbal compounds is in Medicine frutus cnidii, felwort, kuh-seng, the leaf of bamboo, Chinese herbaceous peony, myrrh, Radix Glycyrrhizae, Cortex Phellodendri, the root bark of shaggy-fruited dittany, Fructus Forsythiae, the tuber of stemona, caulis lonicerae, sophora flower are multiple Conjunction is prepared.
2. Chinese herbal compounds according to claim 1, which is characterized in that a kind of Chinese medicine with antibacterial and anti-mite is multiple The active constituent for closing object is prepared by the raw material of following weight percent：
Frutus cnidii 1-20%,
Felwort 1-20%,
Kuh-seng 1-20%,
Leaf of bamboo 1-20%,
Chinese herbaceous peony 1-20%,
Myrrh 1-20%,
Radix Glycyrrhizae 0.5-10%,
Cortex Phellodendri 0.5-10%,
Root bark of shaggy-fruited dittany 0.5-10%,
Fructus Forsythiae 0.5-10%,
Tuber of stemona 0.5-10%,
Caulis lonicerae 0.5-10%
Sophora flower 0.5-10%.
3. Chinese herbal compounds according to claim 2, which is characterized in that a kind of Chinese medicine with antibacterial and anti-mite is multiple The active constituent for closing object is prepared by the raw material of following weight percent：
Frutus cnidii 13-18%,
Felwort 11-16%,
Kuh-seng 7-12%,
Leaf of bamboo 5-10%,
Chinese herbaceous peony 10-15%,
Myrrh 9-14%,
Radix Glycyrrhizae 3-8%,
Cortex Phellodendri 3-8%,
Root bark of shaggy-fruited dittany 2-7%,
Fructus Forsythiae 1-6%,
Tuber of stemona 3-8%,
Caulis lonicerae 1-6%,
Sophora flower 2-7%.
4. Chinese herbal compounds according to claim 3, which is characterized in that a kind of Chinese medicine with antibacterial and anti-mite is multiple The active constituent for closing object is prepared by the raw material of following weight percent：
Frutus cnidii 15%,
Felwort 15%,
Kuh-seng 7%,
The leaf of bamboo 7%；
Chinese herbaceous peony 11%,
Myrrh 11%,
Radix Glycyrrhizae 6%,
Cortex Phellodendri 6%,
The root bark of shaggy-fruited dittany 6%,
Fructus Forsythiae 6%,
The tuber of stemona 4%,
Caulis lonicerae 4%,
Sophora flower 2%.
5. Chinese herbal compounds according to claim 3, which is characterized in that a kind of Chinese medicine with antibacterial and anti-mite is multiple The active constituent for closing object is prepared by the raw material of following weight percent：
Frutus cnidii 20%,
Felwort 15%,
Kuh-seng 12%,
The leaf of bamboo 11%；
Chinese herbaceous peony 9%,
Myrrh 8%,
Radix Glycyrrhizae 8%,
Cortex Phellodendri 6%,
The root bark of shaggy-fruited dittany 6%,
Fructus Forsythiae 2%,
The tuber of stemona 2%,
Caulis lonicerae 0.5%,
Sophora flower 0.5%.
6. a kind of Chinese herbal compounds with antibacterial and anti-mite described in claim 1 are preparing antibacterial, sterilization, anti-inflammatory or are resisting Application in the product of mite.
7. one kind washing shield product, it is characterised in that：It is compound containing a kind of Chinese medicine with antibacterial and anti-mite described in claim 1 Object.
8. one kind according to claim 1 washes shield product, it is characterised in that：The mass percent of the Chinese herbal compounds A concentration of 0.5 ~ 5%.
9. a kind of face cream, it is characterised in that：Contain a kind of Chinese herbal compounds with antibacterial and anti-mite described in claim 1.
10. a kind of face cream according to claim 1, it is characterised in that：The mass percent of the Chinese herbal compounds is dense Degree is 0.5 ~ 5%.
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