CN104189258A - Medicine for treating pruritus - Google Patents
Medicine for treating pruritus Download PDFInfo
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- CN104189258A CN104189258A CN201410368743.4A CN201410368743A CN104189258A CN 104189258 A CN104189258 A CN 104189258A CN 201410368743 A CN201410368743 A CN 201410368743A CN 104189258 A CN104189258 A CN 104189258A
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Abstract
The invention provides a medicine for treating pruritus. The medicine is prepared from the following components: 50-80g of pomegranate rind, 50-80g of Chinese azalea flower, 50-80g of herba agrimoniae, 30-50g of semen torreya, 30-50g of climbing groundsel herb, 30-50g of coptis root, 30-50g of heartleaf houttuynia herb, 30-50g of honeysuckle stem, 30-50g of fructus chebulae, 10-25g of gleditsia sinensis, 10-25g of cicada slough, 10-25g of dark plum, 3-5g of lime and 3-5g of tea oil. The medicine is simple in proportioning, is convenient to use and has good antibacterial effects and obvious delousing effects.
Description
technical field:
The present invention relates to technical field of pharmaceuticals, relate in particular to a kind of skin pruritus medicine.
background technology:
Louse is the parasite that a kind of parasitism is supported one's family by sucking blood in animals, and intimate contact or house pet propagation are main conventionally.Adult and the nymph of louse are sucked blood throughout one's life on pin main body.Host is mainly: Terrestrial mammal animal, and minority is the sea mammals of dwelling, the mankind are also often by parasitism.The louse harm of not only sucking blood, and make host's uneasiness of very itching, and can infect a lot of important person poultry diseases.The relapsing fever of being propagated by louse is global disease, and the pathogen of this disease is a kind of spirillum.In nearly six week in life-span of louse, each female louse approximately produces ten ovum every day, and ovum firmly sticks on people's hair or clothes.Within eight days, the little louse in left and right hatches, and stings at once people and suck blood.After about two or three week, cast off a skin and just can grow for adult by three times.Louse is all parasitic life throughout one's life.People are because contact can be propagated mutually.The propagation of relapsing fever is that it is stung after people, is snapped position and itches very much, and people, can rack louse in the time firmly scratching, and the pathogen in its body fluid is with scratching and bring the wound being snapped into, and people fall ill at this point.
The louse that colonizes in human body has: body louse, and head louse, and three kinds of pubic louses, wherein important with body louse, it is the main media of spread and epidemic class rash, cold, LBRF and trench fever etc.Traditional Therapeutic Method, washes with 10% Radix Stemonae water decoction, also can clean by use 25% Radix Stemonae ethanol (ethanol) solution per week, or cleans with acetum, all can play the effect of delousing.The words of Drug therapy can adopt sulphur ointment and Lindane emulsifiable paste etc.
Along with development in science and technology and social progress; people's hygienic habit changes; often changing a thing often has a bath; seldom there is the situation of the long louse of health; but house pet is more and more, the fur of house pet is the host of louse the best; people and house pet be basis closely, and then causes the situation of also finding louse on the person to happen occasionally.For personal delousing operation, people favor plant source medicine more, for example, and Radix Stemonae aqueous solution etc.In prior art, Chinese patent application 8,910 3338.6 discloses a kind of sterilization, delousing shampoo, its main delousing composition is any or several in the Radix Stemonae, group planting perfume (or spice), Flos Caryophylli, Fructus Cnidii, Li Lu, Radix seu Caulis Derridis Trifoliatae, peppery Miao, Flos Rhododendri Mollis, for another example, it is that antibacterial parasite killing delousing kills the antipruritic easypro skin tincture of demodicid mite that Chinese patent application 201210237575.6 discloses a kind of nanometer silver, and hundred step 100-140g account for 18.5-25.9%; Sulfur 40-80g accounts for 7.4-14.8%; Fructus Carpesii, Radix Sophorae Flavescentis, Cortex Dictamni, the Fructus Kochiae, Galla Chinensis, Fructus Cnidii, Liu Jishuan, Radix Et Rhizoma Rhei, the each 20-60g of sulfur zinc respectively account for 3.7-11.1%.For another example, Chinese patent application 20,121,053 09313 discloses a kind of Chinese medicine for the treatment of enterobiasis, Rhizoma Fagopyri Dibotryis 13-17, Rhizoma Smilacis Glabrae 10-14, Galla Chinensis 13-17, Fructus Cnidii 6, Fructus Rosae Laevigatae 6, Corium Erinacei Seu Hemiechianus 10-14, Herba Plantaginis 1-5, Herba Salviae Chinensis 13-17,
Pseudobulbus Bletillae (Rhizoma Bletillae) 10-14, Folium Artemisiae Argyi 1-5, Radix Notoginseng 6, Radix Stemonae 13-17, Bulbus Allii 10-14, Pericarpium Granati 6, bog moss 10-14.And for example, Chinese patent application 2013106950592 discloses one and has treated dermopathic medicine and preparation, Radix Cynanchi Atrati 20-30g, Aloe 15-35g, Cortex Meliae 30-50g, Alumen 30-50g, Spina Gleditsiae 30-40g, Fructus Bruceae 10-20g, Rhizoma Zingiberis Recens 20-40g, Pericarpium Zanthoxyli 20-30g, Folium Perillae 20-35g, Radix Angelicae Dahuricae 25-40g, Fructus Xanthii 30-40g, Herba Menthae 20-30g, Cortex Phellodendri 35-50g, Radix Sophorae Flavescentis 40-60g, Radix Arnebiae (Radix Lithospermi) 25-35g, Caulis Sargentodoxae 30-50g, Cortex Dictamni 50-70g, Cortex Lycii 30-50g, Radix Cynanchi Paniculati 30-45g, Fructus Kochiae 60-80g, Fructus Cnidii 60-80g, Flos Carthami 30-40g, Fructus Atriplicis Sibiricae 30-40g, Flos Chrysanthemi Indici 40-50g, Radix Stemonae 40-50g, Fructus Psoraleae 40-50g, Flos Caryophylli 30-40g.The present invention on the basis of existing technology, aims to provide a kind of proportioning simple, easy to use, and good antimicrobial effect has a kind of skin pruritus medicine of obvious cootie killing effect.
summary of the invention:
The object of the invention is to overcome the shortcoming existing in prior art, provide a kind of proportioning simple, easy to use, good antimicrobial effect, has a kind of skin pruritus medicine of obvious cootie killing effect.
To achieve these goals, the invention provides a kind of skin pruritus medicine, wherein, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-25g of Fructus Mume, Calx, Oleum Camelliae 3-5g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-20g of Fructus Mume, Calx, Oleum Camelliae 3-4g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 60-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15-25g of Fructus Mume, Calx, Oleum Camelliae 4-5g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 55-75g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 35-45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18-22g of Fructus Mume, Calx, Oleum Camelliae 3.5-4.5g.
The preparation method of medicine for skin pruritus, by Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, the lixiviate of use water extract method three times, after three times lixiviating solution merges, add Calx, steaming and decocting, to the thick Oleum Camelliae that adds, is powder after being dried.
After being dried to powder, the 80-120 order that sieves, after sieve, gains, through the ultra-vioket radiation 15S that sterilizes, obtain skin pruritus medicine of the present invention.
2-acetonylpiperidine in Pericarpium Granati; isopelletierine; have sterilization and disinfestation effect, Pericarpium Granati containing the matter of mixing that contains, after they contact with mucosa, wound surface etc. more; can precipitate or solidify local protein; make to form comparatively fine and close protective layer on surface, contribute to local woanded surface healing or protection part to avoid stimulating, antipruritic; protection wound, Pericarpium Granati decoct has anthelmintic action.Its mechanism system acts on parasitic muscle, makes it sink into continue to shrink, and the effect of tool anthelmintic.Chinese azalea extract in Flos Rhododendri Mollis has significant insecticidal effect, and Herba Agrimoniae has antibacterial disinfective action, the detumescent of simultaneously curing the wound.
Semen Torreyae killing insect and eliminating accumulation, Caulis Lonicerae anti-inflammation, Herba Senecionis Scandentis has bacteriostasis, and in addition, it has insecticidal action containing alkaloid, the effect of Periostracum Cicadae nerve block, insecticidal effect is obvious.Herba Houttuyniae is antibacterial, Rhizoma Coptidis effective ingredient alkaloid has bacteriostasis, Fructus Chebulae has antibacterial action, effective ingredient terchebin is slightly poisonous, have insecticidal effect, Fructus Mume has fungistatic effect, and the gledinin of Fructus Gleditsia has Pesticidal and sterilizing effect, Oleum Camelliae is bits, antipruritic, the effect of deoiling, sterilize, repairing impaired hair quality only, also has obvious blackening and generating hair effect
Calx has the effect of killing pests and suppressing bacteria.
Advantage of the present invention is: proportioning is simple, easy to use, good antimicrobial effect, there is obvious cootie killing effect, the present invention is taking Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae as monarch drug, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae are ministerial drug, and Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, Calx are adjuvant drug, and Oleum Camelliae is for making medicine.Total alkaloid content of the present invention is higher than 1.9%, and biological general glycoside is greater than 1.3%, and louse, fungal infection, bacterial dermatosis patient amount to 120 routine effect comparisons, effective percentage 93.2%.
detailed description of the invention:
Skin pruritus medicine, wherein, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-25g of Fructus Mume.Calx, Oleum Camelliae 3-5g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-20g of Fructus Mume, Calx, Oleum Camelliae 3-4g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 60-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15-25g of Fructus Mume, Calx, Oleum Camelliae 4-5g.
Or, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 55-75g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 35-45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18-22g of Fructus Mume, Calx, Oleum Camelliae 3.5-4.5g.
The preparation method of medicine for skin pruritus, by Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, the lixiviate of use water extract method three times, after three times lixiviating solution merges, add Calx, steaming and decocting, to the thick Oleum Camelliae that adds, is powder after being dried.
After being dried to powder, the 80-120 order that sieves, after sieve, gains, through the ultra-vioket radiation 15S that sterilizes, obtain skin pruritus medicine of the present invention.
Experimental data: with for mycotic experiment
Get 3 parts of each 50g of powder, be respectively charged into 500ml small beaker, add the organic solvent methanol of 5 times of weight of powder.Chloroform, petroleum ether.Under room temperature, soak 3 days, filtering and concentrating is to paste, and take a certain amount of extract and add Tween 80 and make emulsifying agent, 4 degrees Celsius of preservations,
Adopt growth rate method, get the vigorous strain of 6mm colony edge with card punch, be placed on the PDA flat board of dosing and cultivate, the sterilized water that adds equivalent with culture medium contrasts, each repetition 3 times, is placed in 25 degrees Celsius of cultivations, surveys each colony diameter by decussation method, represent the diameter of bacterium colony with meansigma methods, obtain rate of growth=(contrast colony diameter-processing colony diameter)/(contrast colony diameter-0.6) × 100% of Antifungi/antibacterial.(fungal culture)
The extract of 3 kinds of organic solvents is made to the PEA culture medium that final concentration is the extracting solution of 1mg/ml, get the spore suspension 10ul preparing in advance, being inoculated into diameter is the culture dish central authorities of 9cm, logical spreader is smeared evenly, in 25 degrees Celsius of incubators, cultivate 48 hours, observe spore germination quantity, 5 repetitions are established in every processing, average, calculate germination rate and the suppression ratio of spore.
Spore germination rate %=has sprouted spore count/microscopy spore sum × 100%
Suppression ratio %=(contrast germination rate-processing germination rate)/contrast germination rate × 100%
For the experiment of fungus, colony diameter (mm) and suppression ratio (100%), as following table
Delousing experiment:
Be 15%, 25%, 35%, 45% mass percent concentration by the powder proportioning that adds water, get body louse, head louse, and each 100 of pubic louse, spray respectively, then get the Radix Stemonae 10% aqueous solution and spray, and contrasts as follows:
Can find that by aforementioned proportion 15% mass percent concentration cootie killing effect is good.
Alkaloid content determination
Get 100g powder (Pericarpium Granati, Flos Rhododendri Mollis, the each 50g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10g of Fructus Mume.Calx, Oleum Camelliae 3g) as one group.
Get 100g powder (Pericarpium Granati, Flos Rhododendri Mollis, the each 70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15g of Fructus Mume.Calx, Oleum Camelliae 4g).As two groups.
Get 100g powder (Pericarpium Granati, Flos Rhododendri Mollis, the each 60g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18g of Fructus Mume.Calx, Oleum Camelliae 5g).As three groups.
Every group, add 120ml extracting solution (oxolane: water: acetonitrile: acetic acid is by 50:25:20:1 preparation V/V%), smash to pieces and be slurry, filter paper filtering, centrifugal 5 minutes of filtrate, get supernatant 100ml, add 2ml glacial acetic acid, ultrasonic wave concussion 5 minutes, ammonia regulates PH10.5, boiling water is concentrated into dry, twice of a small amount of ammonia scrubbing residue of cooling rear use, centrifugal rear abandoning supernatant, residue water bath method, with 3ml, the phosphoric acid of mass ratio 7% dissolves, centrifugal 5 minutes again, clear liquid is for measuring TGA, select 600nm as measuring wavelength, under room temperature, react 30 minutes with polyformaldehyde phosphoric acid developer, after ultrasonic Treatment, calculate alkaloid, one group 1.97 milligram/gram.Two group 2.03 milligram/gram, three group 1.92 milligram/gram.Show that alkaloid of the present invention is greater than 1.9%.
Biological general glycoside is measured
Glycoside reacts with vanillin-sulfuric acid and produces aubergine, and at 550nm wavelength, there is absorption maximum at place, and within the scope of finite concentration, its concentration is directly proportional to absorbance, taking Saponin as reference substance, and quantitative assay.
Instrument and reagent
1, instrument
(1) visible ultraviolet spectrophotometer or 721 spectrophotometers (2) reflux
(3) single hole water-bath, (4) 10,5ml volumetric flask
(5) 90mm porcelain evaporating dish, (6) 500ml separatory funnel
(7) 10ml tool plug test tube, (8) 250ml flask
(9) measuring pipette
2, reagent
(1) ether, (2) 5% vanillin glacial acetic acid solutions
(3) concentrated sulphuric acid, (4) methanol
(5) n-butyl alcohol, (6) 2mg/ml Saponin standard solution: accurately take saponin monomer standard substance as Saponin Re10mg, be placed in 5ml volumetric flask, add dissolve with methanol and be diluted to scale.
(7) 70% ethanol, (8) glacial acetic acid
Operational approach
Specification Curve of Increasing: accurate Saponin Re standard solution 0,20,40,60,80, the 100ul of drawing, be placed in respectively tool plug test tube, in water-bath, wave most solvent, cooling, then add 5% vanillin glacial acetic acid solution 0.2ml and sulphuric acid sulphur 1.0ml, shake up, capping plug, in 60 DEG C of water-baths, heat 15min, cooling immediately, ice acetic acid 5.0ml, shake up, taking reagent as blank, measure absorbance, drawing standard curve at 550nm ± 1nm wavelength place.
Sample treatment: precision takes the each 10g(Pericarpium Granati of three groups of powder of the present invention, Flos Rhododendri Mollis, the each 50g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10g of Fructus Mume.Calx, Oleum Camelliae 3g) as one group.Pericarpium Granati, Flos Rhododendri Mollis, the each 70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15g of Fructus Mume.Calx, Oleum Camelliae 4g).As two groups.Pericarpium Granati, Flos Rhododendri Mollis, the each 60g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18g of Fructus Mume.Calx, Oleum Camelliae 5g).As three groups.), be placed in respectively 250ml flask, the 40ml that adds diethyl ether, water-bath backflow 2h, fling to the defat sample of ether, then it is colourless to be back to flow liquid with 70% alcoholic solution 30ml, and ether extracted liquid is put in evaporating dish, is concentrated into dryly in water-bath, and the residue 10ml that adds water makes to dissolve.With the full n-butanol extraction closing of 50ml water, re-extract 4 times, merges butanol extraction liquid, with the full Heshui washing of 20ml n-butyl alcohol.Butanol solution is transferred in evaporating dish, is concentrated into dryly in water-bath, with dissolve with methanol residue and transfer them in 10ml volumetric flask, is diluted to scale, shakes up, and obtains test liquid.
Sample determination: draw 20ul test liquid and be placed in tool plug test tube, by the time-and-motion study absorbance under " Specification Curve of Increasing " item, find corresponding total salidroside content on standard curve.
Calculate:
General glycoside (mg/100g)=C*V1*100/m*V2
In formula: C---absorbance per sample, try to achieve the amount of Saponin, mg from standard curve;
V1---sample extraction volume, ml;
V2---sample analysis volume ml;
M---sample quality, g.
Draw one group 1.35 of biological general glycoside milligram/gram, two group 1.42 milligram/gram, three group 1.32 milligram/gram, draw the biological general glycoside about 1.2% of powder of the present invention.
Toxicity:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD 50) > 2000mg/kg,
Belong to low toxicity
Rat glasses are had to the slightly zest to moderate.
Object lesson 1
Liu, man, can find granule worm's ovum at hair follicle root.Paroxysmal pruritus, pruritus is hard to bear, and the part of being stung by pubic louse is rubescent, has little erythema.Use Pericarpium Granati of the present invention, Flos Rhododendri Mollis, the each 50g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10g of Fructus Mume.Calx, Oleum Camelliae 3g.
By Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, the lixiviate of use water extract method three times, after three times lixiviating solution merges, add Calx, steaming and decocting, to the thick Oleum Camelliae that adds, is powder after being dried.The 80-120 order that sieves, after sieve, gains, through the ultra-vioket radiation 15S that sterilizes, obtain skin pruritus medicine of the present invention.Powder is added water and prepares the aqueous solution that becomes 15% mass ratio, clean every day three times, within continuous three days, stop using afterwards, louse disappearance, observed after one week, did not have recurrence, and maintenance good hygiene custom, often has a bath and the thing of changing one's clothes, and visits, not recurrence after half a year.
Object lesson 2
Land, female can see the steel gray mottle that 1cm is large near affected part, and that presses is colour-fast, and the sustainable several months, this steel gray mottle sees breast abdominal part, burst inner side.The pubic louse place of biting magnifier is observed often micropore, local rubescent, has little red stain, has blood crusts on it, local generation anaphylaxis.After scratching, damaged and suppuration, was used Pericarpium Granati of the present invention, Flos Rhododendri Mollis, the each 70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15g of Fructus Mume.Calx, Oleum Camelliae 4g.
By Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, the lixiviate of use water extract method three times, after three times lixiviating solution merges, add Calx, steaming and decocting, to the thick Oleum Camelliae that adds, is powder after being dried.The 80-120 order that sieves, after sieve, gains, through the ultra-vioket radiation 15S that sterilizes, obtain skin pruritus medicine of the present invention.It is 10% methanol solution that powder is added to mass percent, and the mass ratio of powder and methanol solution is 1:15-20, cleans every day three times, within continuous three days, stops using afterwards, louse disappearance, observed after one week, did not have recurrence, kept good hygiene custom, often have a bath and the thing of changing one's clothes, after half a year, visit, not recurrence.
Object lesson 3
Liu, skin pruritus is hard to bear, forms speckle on skin, and the silver bits that drop, scratchiness is strong, is fungal infection, use the present invention (Pericarpium Granati, Flos Rhododendri Mollis, the each 60g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18g of Fructus Mume.The powder that Calx, Oleum Camelliae 5g make) adding water is configured as the aqueous solution of mass percent 15-25%, soaks, and every day, sooner or later once each half an hour, making water temperature was 40-50 degree Celsius.After 3 days, foot's decortication, pruritus stops, and continues to soak, and after 7 days, after Lao Pi takes off, it is bright and clean that foot recovers, and uses new footgear instead, keeps the present invention of every first quarter moon to soak once, visits, not recurrence after half a year.
Object lesson 4
Make pottery certain, the visible erythema of scalp, the alopecia of erythema periphery, erythema place pruritus is hard to bear, uses Pericarpium Granati of the present invention, Flos Rhododendri Mollis, the each 55g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 35g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 12g of Fructus Mume.The powder that Calx, Oleum Camelliae 3g make, adds water and is configured as the solution of mass percent 15%, adds vinegar 5-10ml, cleans hair, once a day, use continuously one week, after one week, the dandruff disappears, after this, keep first quarter moon to wash hair with a present invention, after half a year, visit, not recurrence.
Proportioning is simple, easy to use, good antimicrobial effect, have obvious cootie killing effect, the present invention is taking Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae as monarch drug, and Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae are ministerial drug, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, Calx are adjuvant drug, and Oleum Camelliae is for making medicine.Total alkaloid content of the present invention is higher than 1.9%, and biological general glycoside is greater than 1.3%, and louse (78 example), fungal infection (28 example), bacterial dermatosis patient (14 example) amount to 120 routine effect comparisons, effective percentage 93.2%.
Claims (5)
1. a skin pruritus medicine, is characterized in that, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-25g of Fructus Mume, Calx, Oleum Camelliae 3-5g.
2. skin pruritus medicine according to claim 1, it is characterized in that, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 50-70g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 30-40g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 10-20g of Fructus Mume, Calx, Oleum Camelliae 3-4g.
3. skin pruritus medicine according to claim 1, it is characterized in that, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 60-80g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 40-50g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 15-25g of Fructus Mume, Calx, Oleum Camelliae 4-5g.
4. skin pruritus medicine according to claim 1, it is characterized in that, according to following component preparation, Pericarpium Granati, Flos Rhododendri Mollis, the each 55-75g of Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, the each 35-45g of Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, the each 18-22g of Fructus Mume, Calx, Oleum Camelliae 3.5-4.5g.
One kind as arbitrary in claim 1-4 as described in the preparation method of medicine for skin pruritus, it is characterized in that, by Pericarpium Granati, Flos Rhododendri Mollis, Herba Agrimoniae, Semen Torreyae, Herba Senecionis Scandentis, Rhizoma Coptidis, Herba Houttuyniae, Caulis Lonicerae, Fructus Chebulae, Fructus Gleditsia, Periostracum Cicadae, Fructus Mume, the lixiviate of use water extract method three times, after three times lixiviating solution merges, add Calx, steaming and decocting, to the thick Oleum Camelliae that adds, is powder after being dried.
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| CN201410368743.4A CN104189258A (en) | 2014-07-30 | 2014-07-30 | Medicine for treating pruritus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129509A (en) * | 2007-09-12 | 2008-02-27 | 李丽妮 | Medicament for treating diseases of genitalia and rectum |
| CN101564519A (en) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof |
| KR101208013B1 (en) * | 2012-04-13 | 2012-12-04 | 주식회사 코씨드바이오팜 | A skin-care agent containing mycoleptodonoides aitchisonii mycelium extract |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129509A (en) * | 2007-09-12 | 2008-02-27 | 李丽妮 | Medicament for treating diseases of genitalia and rectum |
| CN101564519A (en) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof |
| KR101208013B1 (en) * | 2012-04-13 | 2012-12-04 | 주식회사 코씨드바이오팜 | A skin-care agent containing mycoleptodonoides aitchisonii mycelium extract |
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