CN102552760A - Nursing liquid for eczema - Google Patents
Nursing liquid for eczema Download PDFInfo
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- CN102552760A CN102552760A CN2012100647116A CN201210064711A CN102552760A CN 102552760 A CN102552760 A CN 102552760A CN 2012100647116 A CN2012100647116 A CN 2012100647116A CN 201210064711 A CN201210064711 A CN 201210064711A CN 102552760 A CN102552760 A CN 102552760A
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Abstract
The invention discloses nursing liquid for eczema. By the nursing liquid, the problem of the treatment of the eczema is solved. The nursing liquid is characterized by being prepared from the following Chinese herbal medicines in part by weight: 10 to 20 parts of japanese honeysuckle stem, 10 to 20 parts of angelica dahurica, 15 to 20 parts of densefruit pittany root-bark, 10 to 15 parts of Siberian cocklour fruit, 1 to 3 parts of chaulmoogratree seed, 10 to 15 parts of akebia fruit, 10 to 20 parts of red paeony root, 6 to 12 parts of lanceolate codonopsis root, 6 to 12 parts of fruit of princesplume ladysthumb, 6 to 12 parts of smilax, 10 to 15 parts of buchnera and 6 to 12 parts of european verbena. Clinical experiments prove that the nursing liquid for treating the eczema has the characteristics of good curative effect and high safety, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of eczema conditioning liquid.
Background technology
Eczema is that a kind of common chronic, recurrent, inflammatory skin are sick, is caused by multiple internal and external factor, and the allergy of, patient's unbalance with skin barrier function atopy body constitution, food and enviromental allergen mediation is relevant.This disease pruritus obviously, the state of an illness repeatedly, have a strong impact on patients ' life quality, particularly sleep quality.Common western medicine is antihistaminic and glucocorticoid; But when patient such as need long-term treatment or the skin lesion zone of receiving treatment are excessive, then might cause untoward reaction such as HPAA (HPA) axle inhibition after the external glucocorticoid systemic absorption.Research in recent years shows that also the field planting rate of staphylococcus aureus is significantly higher than the normal person on the skin of eczema patients, and the quantity of the order of severity of skin lesion and bacteria planting is proportionate; The extracellular toxin that gold Portugal bacterium discharges can bring out and add celsus' papules; And induce the glucocorticoid beta receptor to express, thus suppress glucocorticoid α receptor, make the T cell insensitive to glucocorticoid; Affect the treatment, so cause traditional therapeutic scheme effective percentage to reduce.In addition, hormone or ointment can be used for small size eczema, but the use of large tracts of land eczema uses inconvenience and side effect big.Chinese medicine eczema is evident in efficacy; The rule of treatment is main with expelling wind and removing dampness, heat clearing away often, but this therapeutic scheme for but unsatisfactory curative effect of intractable eczema, its reason is; Humid-heat stagnation is in interior; Dry, the blood stasis of blood that then occurs together for a long time, the wet blood of heat is fought mutually and is fallen ill, clinical medicine or the care product of controlling from the blood system opinion that still lack.
Summary of the invention
Technical assignment of the present invention is the deficiency to above prior art, provides that a kind of curative effect is sure, the little widely used eczema conditioning liquid of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of eczema conditioning liquid; It is characterized in that being processed into by kinds of traditional Chinese medicines, its raw material weight ratio is: 10 ~ 20 parts of Caulis Loniceraes, 10 ~ 20 parts of the Radixs Angelicae Dahuricae, 15 ~ 20 parts of Cortex Dictamnis, 10 ~ 15 parts of Fructus Xanthii, 1 ~ 3 part of Semen Hydnocarpi, 10 ~ 15 parts of Fructus Akebiaes, 10 ~ 20 parts of Radix Paeoniae Rubra, 6 ~ 12 parts of Radix Codonopsis lanceolatae, 6 ~ 12 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Rhizoma Smilacis Chinensiss, 10 ~ 15 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s, 6 ~ 12 parts of Herba Verbenae.
Its preferred weight ratio is: 15 parts of Caulis Loniceraes, 15 parts of the Radixs Angelicae Dahuricae, 18 parts of Cortex Dictamnis, 12 parts of Fructus Xanthii, 2 parts of Semen Hydnocarpis, 12 parts of Fructus Akebiaes, 15 parts of Radix Paeoniae Rubra, 10 parts of Radix Codonopsis lanceolatae, 10 parts of Fructus Polygoni Orientaliss, 10 parts of Rhizoma Smilacis Chinensiss, 12 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s, 10 parts of Herba Verbenae.
Wherein said:
Caulis Lonicerae is the caprifoliaceae plant stem of Radix Ophiopogonis.Nature and flavor are sweet, and are cold.Go into lung, stomach, the heart, spleen channel.But the merit heat-clearing and toxic substances removing, collateral dredging.
The Radix Angelicae Dahuricae is the root of the samphire Radix Angelicae Dahuricae or angelica anomala.Nature and flavor are hot, temperature.Go into lung, stomach warp.But the merit expelling pathogenic wind from the body surface, pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping.
Cortex Dictamni is root or the root bark of cloud savoury herb dittany.Nature and flavor are bitter, and are cold.Go into spleen, stomach, bladder, small intestine meridian.But the merit heat clearing and damp drying is dispeled the wind, detoxifcation.
Herba Xanthii grass is the stem and leaf of feverfew Herba Xanthii.Bitter in the mouth; Hot; Cold nature.Return lung; Spleen; Liver Channel.Merit can be dispeled the wind; Heat radiation; Dehumidifying; Detoxifcation.
Semen Hydnocarpi is the mature seed of Flacourtiaceae plant Semen Hydnocarpi.Acrid in the mouth; Hot in nature.Return liver; Spleen; Kidney channel.But merit dispeiling pathogenic wind and removing dampness; Detoxicating and killing parasites.
Fructus Akebiae is the mature fruit of Lardizabalaceae plant Caulis Akebiae, threeleaf akebia.The property mildly bitter flavor, property is flat.Return liver, stomach, urinary bladder channel.But the merit dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.
Radix Paeoniae Rubra is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Nature and flavor are bitter, are slightly cold.Return Liver Channel.But the merit clearing away heat and cooling blood, eliminating stasis to stop pain.
Radix Codonopsis lanceolatae is the root of campanulaceae plant Lac caprae seu ovis.Sweet in the mouth; Hot; Property is put down.Return spleen; Lung meridian.But merit supplementing QI and nourishing YIN; The detoxifcation removing heat from blood; Evacuation of pus; Eliminating stagnation; Lactogenesis.
Fructus Polygoni Orientalis is the dry mature fruit of polygonaceae plant smartweed.Salty, be slightly cold.Return liver, stomach warp.The merit blood eliminating mass of can loosing, the removing food stagnancy pain relieving.
Rhizoma Smilacis Chinensis is the root stock of liliaceous plant Rhizoma Smilacis Chinensis.Nature and flavor are sweet, light, and are flat.Return liver, stomach warp.But the merit expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, easing joint movement.
Ramulus Euonymi (Herba Buchnerae cruciatae) is the herb of goatweed Ramulus Euonymi (Herba Buchnerae cruciatae).Lightly seasoned; Little hardship; Cool in nature.But merit heat-clearing and toxic substances removing; Cooling blood for hemostasis.
Herba Verbenae is the dry aerial parts of Verenaceae plant Herba Verbenae.Hardship, cold.Return liver, spleen channel.But the merit promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, detoxifcation, inducing diuresis to remove edema.
Composition principle: traditional medicine thinks that eczema is for receiving stagnated fire poison in the rheumatism outward, and the rule of treatment is main with expelling wind and removing dampness, heat clearing away often.But in the actual clinical case, humid-heat stagnation is in interior, dry, the blood stasis of blood that then occurs together for a long time, and the wet blood of heat is fought mutually and is fallen ill, so treatment should be from clearing away heat-damp and promoting diuresis, blood circulation promoting and dispersing pathogen accumulation.So side of the present invention gets the Caulis Lonicerae heat-clearing and toxic substances removing; The Radix Angelicae Dahuricae, Cortex Dictamni, Herba Xanthii grass, Rhizoma Smilacis Chinensis expelling wind and removing dampness; Semen Hydnocarpi dispeiling pathogenic wind and removing dampness counteracting toxic substances; Fructus Akebiae, Radix Codonopsis lanceolatae, Fructus Polygoni Orientalis blood circulation promoting and dispersing pathogen accumulation; Radix Paeoniae Rubra, Ramulus Euonymi (Herba Buchnerae cruciatae), Herba Verbenae clearing away heat and cooling blood; And Caulis Lonicerae, Rhizoma Smilacis Chinensis also have the merit of collateral dredging.Modern pharmacological research shows that simultaneously Radix Paeoniae Rubra has antiinflammatory action, and multiple bacterium is had inhibitory action, and can suppress acetic acid induced mice writhing response, produces analgesic activity etc.; Herba Verbenae contains compositions such as saponin and alkaloid, and stronger antibiotic, antibacterial, anti-inflammatory and analgesic effect are arranged; Cortex Dictamni can obviously suppress CD54 expression, NF-κ B p65 activation and stop the increase of transcribing of NF-κ B p65 mRNA, proteic synthetic to reduce p65, and can the antagonism leukotriene active, reach its antiphlogistic purpose; Caulis Lonicerae extracting solution external xylol causes mice auricle swelling, carrageenin and causes rat paw edema and acetic acid and cause the acute inflammation of mice capillary permeability due to increasing remarkable inhibitory action is all arranged, and can also significantly suppress rat passive cutaneous anaphylaxis, PCA of the same race and the passive cutaneous anaphylaxis, PCA of mice xenogenesis.
When being the expelling wind and removing dampness heat clearing away, prescription characteristics of the present invention take into account blood system, even the intractable eczema of outbreak also has good efficacy repeatedly.Take the conditioning liquid dosage form to avoid gastrointestinal irritation, local application's effect is more direct, and for the large tracts of land skin lesion, can take conditioning liquid dilution back to soak.
The specific embodiment
Below in conjunction with practical situation, specific embodiments of the invention elaborates.
Embodiment 1, crude drug weight: Caulis Lonicerae 10g, Radix Angelicae Dahuricae 10g, Cortex Dictamni 15g, Fructus Xanthii 10g, Semen Hydnocarpi 1g, Fructus Akebiae 10g, Radix Paeoniae Rubra 10g, Radix Codonopsis lanceolatae 6g, Fructus Polygoni Orientalis 6g, Rhizoma Smilacis Chinensis 6g, Ramulus Euonymi (Herba Buchnerae cruciatae) 10g, Herba Verbenae 6g.Above all medicines except that Semen Hydnocarpi mix the back decocting and take concoction, and get filtrating after the filtration, and filtrate to add and pulverize Semen Hydnocarpi powder later, wet dressing, every day is sooner or later respectively once.
Embodiment 2, crude drug weight: Caulis Lonicerae 20g, Radix Angelicae Dahuricae 20g, Cortex Dictamni 20g, Fructus Xanthii 15g, Semen Hydnocarpi 3g, Fructus Akebiae 15g, Radix Paeoniae Rubra 20g, Radix Codonopsis lanceolatae 12g, Fructus Polygoni Orientalis 12g, Rhizoma Smilacis Chinensis 12g, Ramulus Euonymi (Herba Buchnerae cruciatae) 15g, Herba Verbenae 12g.Above all medicines except that Semen Hydnocarpi mix the back decocting and take concoction, and get filtrating after the filtration, and filtrate to add and pulverize Semen Hydnocarpi powder later, wet dressing, every day is sooner or later respectively once.
Embodiment 3, crude drug weight: Caulis Lonicerae 15g, Radix Angelicae Dahuricae 15g, Cortex Dictamni 18g, Fructus Xanthii 12g, Semen Hydnocarpi 2g, Fructus Akebiae 12g, Radix Paeoniae Rubra 15g, Radix Codonopsis lanceolatae 10g, Fructus Polygoni Orientalis 10g, Rhizoma Smilacis Chinensis 10g, Ramulus Euonymi (Herba Buchnerae cruciatae) 12g, Herba Verbenae 10g.Above all medicines except that Semen Hydnocarpi mix the back decocting and take concoction, and get filtrating after the filtration, and filtrate to add and pulverize Semen Hydnocarpi powder later, wet dressing, every day is sooner or later respectively once.
Embodiment 4, crude drug weight: Caulis Lonicerae 30g, Radix Angelicae Dahuricae 25g, Cortex Dictamni 40g, Fructus Xanthii 25g, Semen Hydnocarpi 4g, Fructus Akebiae 25g, Radix Paeoniae Rubra 30g, Radix Codonopsis lanceolatae 15g, Fructus Polygoni Orientalis 15g, Rhizoma Smilacis Chinensis 20g, Ramulus Euonymi (Herba Buchnerae cruciatae) 25g, Herba Verbenae 20g.Above all medicines except that Semen Hydnocarpi mix the back decocting and take concoction, and get filtrating after the filtration, pulverize Semen Hydnocarpi powder later filtrating adding, and the distilled water standardize solution is to 3000ml, and soak in the affected part, each 30min, and every day is sooner or later respectively once.
Effective combination of above-mentioned conditioning liquid is coordinated mutually, expelling wind and removing dampness, and heat clearing and blood circulation promoting, hard masses softening and resolving effectively reach the purpose of eczema affected part nursing, and side effect is less.The above results is that clinical data proves that fully interrelated data is following, and wherein treatment group conditioning liquid is used for the crude drug weight proportion among the embodiment 3.
1 materials and methods
1.1 eczema patients 104 examples of physical data in April, 2008 ~ 2010 year December the court outpatient service prescription on individual diagnosis are divided into 2 groups at random, 51 examples are organized in treatment, male 28 examples, women 23 examples, 22.51 ± 6.8 years old mean age; Matched group 53 examples, male 31 examples, women 22 examples, 29.11 ± 8.1 years old mean age.Two groups of sexes, age differences not statistically significant.The diagnostic criteria of eczema is treated in preceding 2 weeks and was not used glucocorticoid or antihistamine drug with reference to " clinical dermatology ".
1.2 the treatment group of handling the trouble face adopts the embodiment of the invention 3 gained conditioning liquid affected parts directly to smear every day 2 times; Ooze out obvious person and take the soak of stock solution affected part, every day 2 times, each half an hour; Area the greater with stock solution and pure water 1:9 mixed diluting after whole body clean every day 2 times.Matched group affected part hydrocortisone butyrate ointment (trade name: hydrocortisone butyrate, Tianjin Pharmaceutical Group Corp., Ltd produces, the accurate word H10940095 of traditional Chinese medicines) smear, every day 2 times, ooze out obvious person and add with 3% BAS soak.Two groups of treatment times are 14 days.Stop using other for oral administration or external used medicine during two groups of patient treatments, avoid Exposure to Sunlight and pungent zest diet etc., when the treatment later stage xerosis cutis, desquamation or rash occur and itches, can give the vitamin E emulsifiable paste and put skin moistening outward on the skin.
1.3 curative effect determinate standard 3d, 7 d, 14d after the first visit same day and treatment carry out the sign scoring.Sign employing eczema skin lesion area and severity index (eczemaarea and severity index, EASI) point system is divided into 4; Be erythema (erythema; E), swollen firmly or pimple (induration/papulation, I), exfoliation (excoriation, Ex), lichenization (lichenification; L), each sign performance order of severity is divided in 0 ~ 3 minute (0 minute=do not have, 1 minute=light, 2 minutes=in, 3 minutes=weigh).The ratio score value that the skin lesion area accounts for each position area is 0 ~ 6 minute: 0 is divided into no erythra, and 1 is divided into that < 10%, 2 is divided into 10% ~ 19%, and 3 are divided into 20% ~ 49%, and 4 are divided into 50% ~ 69%, and 5 are divided into 70% ~ 89%, and 6 are divided into 90% ~ 100%.Scoring * 100% before therapeutic index=(scoring-treatment back scoring before the treatment)/treatment.Cure and be therapeutic index>=90%; Produce effects is that therapeutic index is 60% ~ 89%; Progressive is therapeutic index 30% ~ 59%; Invalid is therapeutic index<30% or sx.Effective percentage=cure rate+obvious effective rate.
1.4 the statistical method measurement data is represented with x ± s, relatively with the q check, relatively adopts paired t-test before and after the treatment between group; Enumeration data adopts X 2 test; < 0.05 has statistical significance for difference to P.
Effective percentage is 58.82% during 2 treatment groups as a result 3d, and matched group is to compare χ between 69.81%, two group of group
2=1.37, P=0.24; Effective percentage is 76.47% during treatment group 7d, and matched group is to compare χ between 73.58%, two group of group
2=0.11, P=0.73; Effective percentage is 86.27% during treatment group 14d, and matched group is to compare χ between 86.79%, two group of group
2=0.01, P=0.93.With comparing difference not statistically significant between two groups of time points (P>0.05), show two groups of therapeutic equivalences.
2.4 in the recurrence situation 6 months, the treatment group recurs 9 examples (17.65%), matched group recurs 10 examples (18.87%), and comparing difference not statistically significant between two groups (χ 2=0.02, P=0.87).
2.5 untoward reaction does not appear in untoward reaction and toleration treatment group, matched group has 1 example scorching hot dry desquamation to occur when first week.
3. this result of study of conclusion shows; The present invention can effectively improve the eczema patient symptom, its effect and glucocorticoid are suitable, but has avoided using the rebound phenomenon that occurs after untoward reaction and the drug withdrawal due to the ointment; There is not obvious side reaction; And, especially be suitable for child patient and the extensive person of skin lesion area, worth clinical selecting for use outward because of it not only can have been put on the skin, but soak but also washout are taken a shower.
Claims (2)
1. eczema conditioning liquid; It is characterized in that being processed into by kinds of traditional Chinese medicines, its crude drug weight ratio is: 10 ~ 20 parts of Caulis Loniceraes, 10 ~ 20 parts of the Radixs Angelicae Dahuricae, 15 ~ 20 parts of Cortex Dictamnis, 10 ~ 15 parts of Fructus Xanthii, 1 ~ 3 part of Semen Hydnocarpi, 10 ~ 15 parts of Fructus Akebiaes, 10 ~ 20 parts of Radix Paeoniae Rubra, 6 ~ 12 parts of Radix Codonopsis lanceolatae, 6 ~ 12 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Rhizoma Smilacis Chinensiss, 10 ~ 15 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s, 6 ~ 12 parts of Herba Verbenae.
2. a kind of eczema conditioning liquid according to claim 1; It is characterized in that being processed into by kinds of traditional Chinese medicines, its crude drug weight ratio is: 15 parts of Caulis Loniceraes, 15 parts of the Radixs Angelicae Dahuricae, 18 parts of Cortex Dictamnis, 12 parts of Fructus Xanthii, 2 parts of Semen Hydnocarpis, 12 parts of Fructus Akebiaes, 15 parts of Radix Paeoniae Rubra, 10 parts of Radix Codonopsis lanceolatae, 10 parts of Fructus Polygoni Orientaliss, 10 parts of Rhizoma Smilacis Chinensiss, 12 parts of Ramulus Euonymi (Herba Buchnerae cruciatae)s, 10 parts of Herba Verbenae.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103721065A (en) * | 2014-01-13 | 2014-04-16 | 彭青 | Preparation method of preoperative care substance for anorectal operation |
| CN103721064A (en) * | 2014-01-13 | 2014-04-16 | 张卫华 | Medicine for treating perianal eczema |
| CN105920602A (en) * | 2016-06-28 | 2016-09-07 | 西安交通大学 | Application of NF-kappa B p65/HMGCS2 regulation approach in preparation of medicines for regulating ketone body synthesis |
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| CN101564519A (en) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof |
| CN101849983A (en) * | 2010-06-10 | 2010-10-06 | 吴启明 | Medicament for treating eczema |
| CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
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- 2012-03-13 CN CN 201210064711 patent/CN102552760B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101564519A (en) * | 2009-06-05 | 2009-10-28 | 中国人民解放军军事医学科学院军事兽医研究所 | External medicine for treating parasitic infection, fungal infection and bacterial infection of pets and preparation method thereof |
| CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
| CN101849983A (en) * | 2010-06-10 | 2010-10-06 | 吴启明 | Medicament for treating eczema |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721065A (en) * | 2014-01-13 | 2014-04-16 | 彭青 | Preparation method of preoperative care substance for anorectal operation |
| CN103721064A (en) * | 2014-01-13 | 2014-04-16 | 张卫华 | Medicine for treating perianal eczema |
| CN103721064B (en) * | 2014-01-13 | 2015-11-11 | 张卫华 | A kind of medicine for the treatment of anal eczema |
| CN105920602A (en) * | 2016-06-28 | 2016-09-07 | 西安交通大学 | Application of NF-kappa B p65/HMGCS2 regulation approach in preparation of medicines for regulating ketone body synthesis |
| CN105920602B (en) * | 2016-06-28 | 2021-07-06 | 西安交通大学 | Application of NF-kappa B p65/HMGCS2 regulation pathway in preparation of medicine for regulating synthesis of ketone body |
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