CN103721065A - Preparation method of preoperative care substance for anorectal operation - Google Patents
Preparation method of preoperative care substance for anorectal operation Download PDFInfo
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Abstract
The invention discloses a preparation method of a preoperative pharmaceutical composition for anorectal operation and aims to solve the problem in preoperative care for anorectal operation. The preparation method is characterized by comprising the following steps: (1) extracting volatile oil from Semen Citri Reticulatae, flame leaf birch bark coarse powder, elsholtzia, Trachelospermum jasminoides coarse powder and fistular onion stalk for later use; (2) pulverizing yellow gelatin and stir-fried haricot into fine powder for later use; (3) carrying out water extraction and alcohol precipitation on Bulbophyllum inconspicuum Maxim, Oxalis pes-caprae, retinervus luffae fructus, Cladostachys amaranthoides, cymose buckwheat rhizome stem and leaf and decoction dregs obtained in the step (1), taking the centrifugate, concentrating and carrying out spray drying to obtain a primary material; and (4) spraying the volatile oil obtained in the step (1) into the primary material obtained in the step (3), adding the fine powder obtained in the step (2), evenly mixing, passing through a 100-mesh screen, sterilizing and subpackaging. The clinical experiment proves that the preoperative care substance is suitable for preoperative application of anorectal operation, has the characteristics of favorable curative effect and high safety, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preoperative preparation method that makes pharmaceutical composition of anal-surgery that is applicable to.
Background technology
Anal-surgery comprises internal hemorrhoid, external hemorrhoid, mixed hemorrhoid etc., and postoperative common complication has that pain, wound are hemorrhage, Anal edema, constipation, abdominal distention, fever etc.
The nursing of anal-surgery at present is mainly postoperative care, and in recent years, more and more evidence shows, in art, crissum and anegenitical ring state and incidence of complications and Degree of Accord Relation are close.Because operation itself is also a kind of extraneous wound for body, after wound, local stress is crossed and can be caused by force local inflammatory response too strong, cause pain, edema obvious, even primosome temperature rise, and this fervescence and infection uncorrelated, but the thermoregulation obstacle that a kind of stress state causes.In addition, anal-surgery routine need to be cooked coloclysis processing, and coloclysis itself can promote the irritability of crissum, and high quick patient even not yet performs the operation and just occurs anus redness, affects surgical effect.
So urgent clinical needs are now a kind of, for anal-surgery preoperative care thing, reduce the stimulation that preoperative coloclysis produces for anus, and contribute to reduce the nursing thing of the local the state of high stress of anus simultaneously.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and side effect is little is applicable to the preoperative preparation method that makes pharmaceutical composition of anal-surgery.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition that is applicable to the preoperative use of anal-surgery, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Bulbophylli inconspicui, 6 ~ 12 parts of Semen corchoris, 6 ~ 12 parts of 3 ~ 10 parts, nine layers wind of Retinervus Luffae Fructus, 3 ~ 10 parts of Herba Moslaes, 6 ~ 12 parts of gelatinum oxhide, 6 ~ 12 parts of Semen Citri Reticulataes, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of stir-fried kidney beans, 1 ~ 5 part of Cortex Betulae Luminiferae, 3 ~ 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 ~ 25 parts of Bulbus Allii Fistulosi.
Chinese medicine of the present invention can be prepared from by following method:
(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
Wherein said: Herba Bulbophylli inconspicui, for the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.Nature and flavor are sweet; Pungent; Cool; Nontoxic.Return lung; Stomach warp.Merit can heat clearing away YIN nourishing; Nourishing the lung to arrest cough.
Semen corchori is the seed of Tiliaceae plant Corchorus olitorius L. Corchorus capsularis L..Nature and flavor hardship; Temperature.Return lung; Liver; Kidney channel.Merit can be invigorated blood circulation; Regulating menstruation; Cough-relieving.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor hardship, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, invigorates blood circulation, and dredging collateral.
Herba Moslae is the dry aerial parts of labiate Mosla chinensis Maxim..Nature and flavor are pungent, tepor.Attach to the lung and stomach meridians.Merit can relieving the exterior syndrome by diaphoresis, and middle dampness removing.
Gelatinum oxhide, the glue of making for the gelatinum oxhide skin that is bovid cattle Bos taurus domesticus Gmelin.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Merit can be nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.
Semen Citri Reticulatae is the seed of rutaceae orange Citrus reticulata Blanco.There is oiliness.Feeble QI, mildly bitter flavor.Nature and flavor are flat bitter; Return liver, kidney channel.Merit can be regulated the flow of vital energy, eliminating stagnation, pain relieving.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.
Stir-fried kidney beans, is the dry mature seed of pulse family Dolichos plant Seem Lablab Album, fries to micro-yellow, and the used time smashs to pieces.Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.
Cortex Betulae Luminiferae is Betulaceae betula luminifera Betula luminifera H. Win Flos jasmini. bark.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.
Rhizoma Fagopyri Dibotryis stem and leaf is the stem and leaf of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Nature and flavor hardship, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.
Bulbus Allii Fistulosi, is the cauloid of Liliaceae allium Herba Alii fistulosi, and merit can be delivered and activate yang, removing toxic substances parasite killing.
Composition principle: in art, crissum and anegenitical ring state and incidence of complications and Degree of Accord Relation are close.Because operation itself is also a kind of extraneous wound for body, after wound, local stress is crossed and can be caused by force local inflammatory response too strong, cause pain, edema obvious, even primosome temperature rise, and this fervescence and infection uncorrelated, but the thermoregulation obstacle that a kind of stress state causes.In addition, anal-surgery routine need to be cooked coloclysis processing, and coloclysis itself can promote the irritability of crissum, and high quick patient even not yet performs the operation and just occurs anus redness, affects surgical effect.Inventor's clinical research finds, the key link that reduces crissum stress state be local nerve functional status and
Compared with prior art, the present invention has following characteristics:
1, prescription uniqueness: get Herba Bulbophylli inconspicui, Semen corchori in side for monarch, described Herba Bulbophylli inconspicui, Semen corchori coordinate, and the two is lung meridian medication, and lung large intestine phase the exterior and the interior, so the two can enter large intestine; The feature of Herba Bulbophylli inconspicui is heat clearing away, but nature and flavor are sweet cool; There is the merit of sweet profit, simultaneously can YIN nourishing; In rat inflammatory pain model, the Herba Bulbophylli inconspicui water extraction liquid of 1mg/kg can reduce localized heat shock protein (HSP) expresses; The bitter temperature of Semen corchori, for rat skin lesion model, the Corchorus olitorius L. glycoside extract of 0.1mg/kg is local to be used, and can make local mast cell activity reduce, and then resists local nerve hypersensitive state excitation;
2, in side, getting Herba Moslae is minister, the outer dampness of Herba Moslae solution Intradermal film, and Herba Moslae volatile oil can weaken rabbit local inflammation response strength;
3, getting Retinervus Luffae Fructus, Caulis Trachelospermi, nine layers of wind promoting blood circulation to remove obstruction in the collateral is minister, and inventor for many years Clinical and experimental study show, Caulis Trachelospermi, Retinervus Luffae Fructus can be alleviated rapidly the high quick pruritus sense of discomfort of bringing of local nerve; Get the Semen Citri Reticulatae eliminating stagnation of regulating the flow of vital energy; Gelatinum oxhide is nourshing Yin and drynsessmoistening prescription to nourish blood;
4, make medication pair: Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, the two heat one is cold, forms medicine pair, jointly reaching the effect of drying and unbiased, and has the effect of removing toxic substances;
5, gelatinum oxhide is rich in colloidality, stir-fried kidney beans rich in starch, and the two local use contributes to increase local skin cytotrophy state;
6, Bulbus Allii Fistulosi merit can be delivered and activate yang, and the effect in we is to increase medicine entirety transdermal absorption factor;
7, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Herba Bulbophylli inconspicui, 10 parts of Semen corchoris, 10 parts of 6 parts, nine layers wind of Retinervus Luffae Fructus, 6 parts of Herba Moslaes, 10 parts of gelatinum oxhide, 10 parts of Semen Citri Reticulataes, 10 parts of Caulis Trachelospermis, 10 parts of stir-fried kidney beans, 2 parts of Cortex Betulae Luminiferaes, 6 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 20 parts of Bulbus Allii Fistulosi.
The preparation method of embodiment 1 is: Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Herba Moslae, gelatinum oxhide, Semen Citri Reticulatae, Caulis Trachelospermi, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Bulbus Allii Fistulosi mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and gets appropriate morning and evening crissum local wet dressing preoperative three day every day.
Embodiment 2, raw material weight proportioning: 10 parts of Herba Bulbophylli inconspicui, 6 parts of Semen corchoris, 6 parts of 3 parts, nine layers wind of Retinervus Luffae Fructus, 3 parts of Herba Moslaes, 6 parts of gelatinum oxhide, 6 parts of Semen Citri Reticulataes, 6 parts of Caulis Trachelospermis, 6 parts of stir-fried kidney beans, 1 part of Cortex Betulae Luminiferae, 3 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 parts of Bulbus Allii Fistulosi.
Embodiment 3, raw material weight proportioning: 20 parts of Herba Bulbophylli inconspicui, 10 parts of Semen corchoris, 10 parts of 6 parts, nine layers wind of Retinervus Luffae Fructus, 6 parts of Herba Moslaes, 10 parts of gelatinum oxhide, 10 parts of Semen Citri Reticulataes, 10 parts of Caulis Trachelospermis, 10 parts of stir-fried kidney beans, 2 parts of Cortex Betulae Luminiferaes, 6 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 20 parts of Bulbus Allii Fistulosi.
Embodiment 4, raw material weight proportioning: 30 parts of Herba Bulbophylli inconspicui, 12 parts of Semen corchoris, 12 parts of 10 parts, nine layers wind of Retinervus Luffae Fructus, 10 parts of Herba Moslaes, 12 parts of gelatinum oxhide, 12 parts of Semen Citri Reticulataes, 12 parts of Caulis Trachelospermis, 12 parts of stir-fried kidney beans, 5 parts of Cortex Betulae Luminiferaes, 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 25 parts of Bulbus Allii Fistulosi.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
During use, the hot water of 50 ℃ of left and right tunes to open, and get and spread in right amount crissum part preoperative three day every day.
Effective combination of said medicine, coordinates mutually, effectively reach the object that is applicable to the preoperative use of anal-surgery, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in December, 2011 ~ 2012 year December is without anorectal surgery patient 103 examples of selecting a time of open wound, male 55 examples, female's 48 examples, 18～70 years old age, average (32.7 ± 3.4) year.Wherein external hemorrhoid 29 examples, internal hemorrhoid 18 examples, mixed hemorrhoid 44 examples, hypertrophy of anal papilla 4 examples, rectal cancer 8 examples.Before all operation in patients, all carry out cleansing enema.
1.1.2 grouping: be divided at random matched group 34 examples, soak group 34 examples, dress group 35 examples.Three groups of cases difference not statistically significant (P>0.05) on sex, age, disease distribute, has comparability.
1.2 method.
1.2.1 Therapeutic Method: three groups of first three days of difference Rhizoma Atractylodis Macrocephalae, matched group normal saline soak, 2 times/d; Soak group is with gained decoction crissum local wet dressing in the embodiment of the present invention 1,2 times/d; Dress group and dress after melting with gained medicated powder hot water in the embodiment of the present invention 2,2 times/d.
1.2.2 observation index: pain situation, use analgesic drug product situation in postoperative 3d; Record and postoperatively whether exist hemorrhage, dizzy, nauseating, the complication such as blood pressure increases, non-infectious fervescence to occur situation.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
2.1 3 groups of postoperative pain situations comparison: all patients all exist postoperative pain, wherein pain cannot be stood, need to use the ratio of analgesic to be: matched group 85.29%(29/34), soak group 47.06%(16/34), dress group 42.86%(15/35), the ratio of matched group use medicine analgesic is apparently higher than soak group and dress group (P<0.05).
In 2.2 postoperative 3d there is situation comparison in non-infectious complication: in matched group 34 examples, have 12 routine patients that one or several complication (postoperative early stage hemorrhage second operation sewing hemostasis 3 examples again that need occur; Postoperative dizzy 2 examples; Non-infectious fervescence 8 examples; Blood pressure increases 5 examples; Nauseating 3 examples), complication rate is 35.29%.In soak group 34 examples, there are 5 routine patients that one or several complication (postoperative early stage hemorrhage second operation sewing hemostasis 1 example again that needs occur; Non-infectious fervescence 2 examples; Blood pressure increases 4 examples), complication rate is 14.71%.Dressing in group 35 examples has 5 routine patients that one or several complication (postoperative early stage hemorrhage second operation sewing hemostasis 2 examples again that need occur; Non-infectious fervescence 2 examples; Blood pressure increases 3 examples), complication rate is 14.29%.The non-infectious complication ratio of matched group is apparently higher than soak group and dress group, and difference has statistical significance (P<0.05).
2.3 soak groups are organized patient's rate of adverse reactions with dressing: two groups all do not have obvious adverse reaction report.
3. conclusion.
This result of study shows, use soak group of the present invention and dress the preoperative intervention effect of group good, postoperative non-infectious complication is starkly lower than matched group, and can obviously reduce the utilization rate of postoperative analgesia medicine, the incidence rate of the untoward reaction of medicine own is low, illustrates that the present invention has that untoward reaction is light, the higher advantage of safety being applicable to the preoperative use of anal-surgery.
Claims (1)
1. one kind is applicable to the preoperative preparation method that makes pharmaceutical composition of anal-surgery, it is characterized in that, crude drug comprises Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Herba Moslae, gelatinum oxhide, Semen Citri Reticulatae, Caulis Trachelospermi, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Bulbus Allii Fistulosi, following steps, consists of:
(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102526694A (en) * | 2012-03-14 | 2012-07-04 | 刘晓枫 | Lotion beneficial to health of anus and preparation method thereof |
| CN102552760A (en) * | 2012-03-13 | 2012-07-11 | 陈淑香 | Nursing liquid for eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102552760A (en) * | 2012-03-13 | 2012-07-11 | 陈淑香 | Nursing liquid for eczema |
| CN102526694A (en) * | 2012-03-14 | 2012-07-04 | 刘晓枫 | Lotion beneficial to health of anus and preparation method thereof |
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