CN103721065B - A kind of preparation method of preoperative care substance for anorectal operation - Google Patents

Abstract

The invention discloses and be a kind ofly applicable to the preoperative preparation method making pharmaceutical composition of anal-surgery, to solve anal-surgery preoperative care problem.It is characterized in that preparation method comprises: (1) by Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi extract volatile oil for subsequent use; (2) by gelatinum oxhide, that stir-fried kidney beans is ground into fine powder is for subsequent use; (3) by gained medicinal residues water extract-alcohol precipitation in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1, extracting centrifugal liquid concentrated spray is dry, obtains just material; (4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained fine powder mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.Clinical trial certificate: the present invention is applicable to the preoperative use of anal-surgery, has good effect and the higher feature of safety, clinic application, promotes.

Description

A kind of preparation method of preoperative care substance for anorectal operation

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind ofly be applicable to the preoperative preparation method making pharmaceutical composition of anal-surgery.

Background technology

Anal-surgery comprises internal hemorrhoid, external hemorrhoid, mixed hemorrhoid etc., postoperative common complication has that pain, wound are hemorrhage, Anal edema, constipation, abdominal distention, fever etc.

The nursing of current anal-surgery is mainly postoperative care, and in recent years, increasing evidence shows, in art crissum and anegenitical ring state and incidence of complications and Degree of Accord Relation close.Because operation itself is also a kind of extraneous wound for body, after wound, local stress is crossed and local inflammatory response then can be caused too strong by force, cause pain, edema obvious, even primosome temperature rise, and this body temperature raises and infect and uncorrelated, but the thermoregulatory dysfunctions that a kind of stress state causes.In addition, anal-surgery routine needs to cook coloclysis process, and coloclysis itself can promote the irritability of crissum, and high quick patient even not yet performs the operation and just occurs that anus is red and swollen, affects surgical effect.

So now urgent clinical needs are a kind of reduce for preoperative care substance for anorectal operation the stimulation that preoperative coloclysis produces for anus, and contribute to reducing the nursing thing of anus locally the state of high stress simultaneously.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provide a kind of curative effect certainly and side effect little be applicable to the preoperative preparation method making pharmaceutical composition of anal-surgery.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition being applicable to the preoperative use of anal-surgery, it is characterized in that being prepared from by the crude drug of following weight proportion: Herba Bulbophylli inconspicui 10 ~ 30 parts, Semen corchori 6 ~ 12 parts, Retinervus Luffae Fructus 3 ~ 10 parts, nine layers of wind 6 ~ 12 parts, Herba Moslae 3 ~ 10 parts, gelatinum oxhide 6 ~ 12 parts, Semen Citri Reticulatae 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, stir-fried kidney beans 6 ~ 12 parts, Cortex Betulae Luminiferae 1 ~ 5 part, Rhizoma Fagopyri Dibotryis stem and leaf 3 ~ 10 parts, Bulbus Allii Fistulosi 10 ~ 25 parts.

Chinese medicine of the present invention can be prepared from by following method:

(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, for subsequent use after the medicinal residues mixing after extraction;

(2) gelatinum oxhide, stir-fried kidney beans are pulverized 150 mesh sieves respectively, become fine powder mixing for standby use;

(3) gained medicinal residues mixing in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 is added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray is dry, obtains just material;

(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained mixing fine powders mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.

Wherein said: Herba Bulbophylli inconspicui is the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui BulbophylluminconspicuumMaxim., with all herbal medicine.Nature and flavor are sweet; Pungent; Cool; Nontoxic.Return lung; Stomach warp.Merit can heat clearing away YIN nourishing; Nourishing the lung to arrest cough.

Semen corchori is the seed of Tiliaceae plant Corchorus olitorius L. CorchoruscapsularisL..Nature and flavor are bitter; Temperature.Return lung; Liver; Kidney channel.Merit can be invigorated blood circulation; Regulating menstruation; Cough-relieving.

Retinervus Luffae Fructus is cucurbitaceous plant Fructus Luffae Luffacylindrica(L.) vascular bundle of the dry mature fruit of Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, dispels the wind.

Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus SpatholobussuberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, and invigorates blood circulation, dredging collateral.

Herba Moslae is the dry aerial parts of labiate Mosla chinensis Maxim..Nature and flavor are pungent, tepor.Attach to the lung and stomach meridians.Merit can relieving the exterior syndrome by diaphoresis, and middle dampness removing.

Gelatinum oxhide is the glue that the gelatinum oxhide skin that is bovid cattle BostaurusdomesticusGmelin is made.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Merit can be nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.

Semen Citri Reticulatae is the seed of rutaceae orange CitrusreticulataBlanco.There is oiliness.Feeble QI, mildly bitter flavor.Nature and flavor are flat bitter; Return liver, kidney channel.Merit can be regulated the flow of vital energy, eliminating stagnation, pain relieving.

Caulis Trachelospermi is apocynaceae plant trachelospermum jasminoide Trachelospermumjasminoides(Lindl.) the dry zone leaf rattan of Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.

Stir-fried kidney beans is the dry mature seed of pulse family Dolichos plant Seem Lablab Album, and fry to micro-yellow, the used time smashs to pieces.Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.

Cortex Betulae Luminiferae is Betulaceae betula luminifera BetulaluminiferaH.Win Flos jasmini. bark.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.

Rhizoma Fagopyri Dibotryis stem and leaf is polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrumdibotrys(D.Don) stem and leaf of Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.

Bulbus Allii Fistulosi, be the cauloid of Liliaceae allium Herba Alii fistulosi, merit can be delivered and activate yang, removing toxic substances parasite killing.

Composition principle: in art crissum and anegenitical ring state and incidence of complications and Degree of Accord Relation close.Because operation itself is also a kind of extraneous wound for body, after wound, local stress is crossed and local inflammatory response then can be caused too strong by force, cause pain, edema obvious, even primosome temperature rise, and this body temperature raises and infect and uncorrelated, but the thermoregulatory dysfunctions that a kind of stress state causes.In addition, anal-surgery routine needs to cook coloclysis process, and coloclysis itself can promote the irritability of crissum, and high quick patient even not yet performs the operation and just occurs that anus is red and swollen, affects surgical effect.Inventor's clinical research finds, the key link reducing crissum stress state be local nerve functional status and

Compared with prior art, the present invention has following characteristics:

1, prescription is unique: get Herba Bulbophylli inconspicui in side, Semen corchori is monarch, the cooperation of described Herba Bulbophylli inconspicui, Semen corchori, the two is lung meridian medication, lung large intestine phase the exterior and the interior, so the two can enter large intestine; The feature of Herba Bulbophylli inconspicui is heat clearing away, but nature and flavor are sweet cool; There is the merit of sweet profit, simultaneously can YIN nourishing; For in rat inflammatory pain model, the Herba Bulbophylli inconspicui Aqueous extracts of 1mg/kg can reduce localized heat shock protein (HSP) expresses; The bitter temperature of Semen corchori, for rat skin lesion model, the Corchorus olitorius L. glycoside extract local of 0.1mg/kg uses, and local mast cell activity can be made to reduce, then resist local nerve hypersensitive state excitation;

2, getting Herba Moslae in side is minister, the outer dampness of Herba Moslae solution Intradermal film, and Herba Moslae volatile oil can weaken rabbit local inflammation response strength;

3, get Retinervus Luffae Fructus, Caulis Trachelospermi, nine layers of wind promoting blood circulation to remove obstruction in the collateral be minister, and inventor for many years Clinical and experimental study show, Caulis Trachelospermi, Retinervus Luffae Fructus can alleviate rapidly the pruritus sense of discomfort that local nerve high sensitive strip is come; Get Semen Citri Reticulatae to regulate the flow of vital energy eliminating stagnation; Gelatinum oxhide is nourshing Yin and drynsessmoistening prescription to nourish blood;

4, make medication pair: Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, the two heat one is trembled with fear, and forms medicine pair, jointly reaching the effect of drying and unbiased, and having effect of removing toxic substances;

5, gelatinum oxhide is rich in colloidality, stir-fried kidney beans rich in starch, and the two local uses and contributes to increasing local skin cytotrophy state;

6, Bulbus Allii Fistulosi merit can be delivered and activate yang, and the effect in we increases the overall transdermal absorption factor of medicine;

7, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.

Detailed description of the invention

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: Herba Bulbophylli inconspicui 20 parts, Semen corchori 10 parts, Retinervus Luffae Fructus 6 parts, nine layers of wind 10 parts, Herba Moslae 6 parts, gelatinum oxhide 10 parts, Semen Citri Reticulatae 10 parts, Caulis Trachelospermi 10 parts, stir-fried kidney beans 10 parts, Cortex Betulae Luminiferae 2 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 parts, Bulbus Allii Fistulosi 20 parts.

The preparation method of embodiment 1 is: Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Herba Moslae, gelatinum oxhide, Semen Citri Reticulatae, Caulis Trachelospermi, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Bulbus Allii Fistulosi mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and gets appropriate crissum local wet dressing sooner or later preoperative three day every day.

Embodiment 2, raw material weight proportioning: Herba Bulbophylli inconspicui 10 parts, Semen corchori 6 parts, Retinervus Luffae Fructus 3 parts, nine layers of wind 6 parts, Herba Moslae 3 parts, gelatinum oxhide 6 parts, Semen Citri Reticulatae 6 parts, Caulis Trachelospermi 6 parts, stir-fried kidney beans 6 parts, Cortex Betulae Luminiferae 1 part, Rhizoma Fagopyri Dibotryis stem and leaf 3 parts, Bulbus Allii Fistulosi 10 parts.

Embodiment 3, raw material weight proportioning: Herba Bulbophylli inconspicui 20 parts, Semen corchori 10 parts, Retinervus Luffae Fructus 6 parts, nine layers of wind 10 parts, Herba Moslae 6 parts, gelatinum oxhide 10 parts, Semen Citri Reticulatae 10 parts, Caulis Trachelospermi 10 parts, stir-fried kidney beans 10 parts, Cortex Betulae Luminiferae 2 parts, Rhizoma Fagopyri Dibotryis stem and leaf 6 parts, Bulbus Allii Fistulosi 20 parts.

Embodiment 4, raw material weight proportioning: Herba Bulbophylli inconspicui 30 parts, Semen corchori 12 parts, Retinervus Luffae Fructus 10 parts, nine layers of wind 12 parts, Herba Moslae 10 parts, gelatinum oxhide 12 parts, Semen Citri Reticulatae 12 parts, Caulis Trachelospermi 12 parts, stir-fried kidney beans 12 parts, Cortex Betulae Luminiferae 5 parts, Rhizoma Fagopyri Dibotryis stem and leaf 10 parts, Bulbus Allii Fistulosi 25 parts.

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, for subsequent use after the medicinal residues mixing after extraction;

(2) gelatinum oxhide, stir-fried kidney beans are pulverized 150 mesh sieves respectively, become fine powder mixing for standby use;

(3) gained medicinal residues mixing in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 is added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray is dry, obtains just material;

(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained mixing fine powders mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.

During use, the hot water of about 50 DEG C tunes to open, and gets preoperative three day every day and spreads on crissum local in right amount.

The efficient combination of said medicine, coordinates mutually, effectively reach the object being applicable to the preoperative use of anal-surgery, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.

1 object and method.

1.1 object.

1.1.1 case selection: in December, 2011 ~ 2012 year December without anorectal surgery patient 103 example of selecting a time of open wound, man 55 example, female 48 example, 18 ~ 70 years old age, average (32.7 ± 3.4) year.Wherein external hemorrhoid 29 example, internal hemorrhoid 18 example, mixed hemorrhoid 44 example, hypertrophy of anal papilla 4 example, rectal cancer 8 example.All cleansing enema is carried out before all operation in patients.

1.1.2 divide into groups: be divided into matched group 34 example at random, soak group 34 example, dresses group 35 example.Three groups of cases no significant difference (P>0.05) on sex, age, Disease Distribution, has comparability.

1.2 method.

1.2.1 Therapeutic Method: other first three sky of Rhizoma Atractylodis Macrocephalae of three components, matched group normal saline soak, 2 times/d; Soak group with gained decoction crissum local wet dressing in the embodiment of the present invention 1,2 times/d; Dress group to dress after melting with gained medicated powder hot water in the embodiment of the present invention 2,2 times/d.

1.2.2 observation index: pain condition, use analgesic drug product situation in postoperative 3d; Record and postoperatively whether there is hemorrhage, dizzy, nauseating, the complication such as blood pressure increases, non-infectious body temperature rising and occur situation.

1.2.3 statistical analysis: SPSS13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ ²inspection.

2 results.

2.1 3 groups of postoperative pain situations compare: all patients all exist postoperative pain, wherein pain cannot be stood, need to use the ratio of analgesic be: matched group 85.29%(29/34), soak group 47.06%(16/34), dress group 42.86%(15/35), matched group uses the ratio of medicine analgesic apparently higher than soak group and dresses group (P<0.05).

In 2.2 postoperative 3d, non-infectious complication occurs that situation compares: (early postoperation is hemorrhage needs second operation sewing hemostasis 3 example again to have 12 routine patients that one or several complication occur in matched group 34 example; Postoperative dizzy 2 examples; Non-infectious body temperature raises 8 examples; Blood pressure increases 5 examples; Nauseating 3 examples), complication rate is 35.29%.(early postoperation is hemorrhage needs second operation sewing hemostasis 1 example again to have 5 routine patients that one or several complication occur in soak group 34 example; Non-infectious body temperature raises 2 examples; Blood pressure increases 4 examples), complication rate is 14.71%.Dress in group 35 example have 5 routine patients that one or several complication occur (early postoperation is hemorrhage needs second operation sewing hemostasis 2 example again; Non-infectious body temperature raises 2 examples; Blood pressure increases 3 examples), complication rate is 14.29%.The non-infectious complication rate of matched group is apparently higher than soak group and dress group, and difference has statistical significance (P<0.05).

2.3 soak groups organize Patient drug's adverse reaction rate with dressing: two groups all do not have obvious adverse reaction to report.

3. conclusion.

This result of study shows, use soak group of the present invention and dress the preoperative intervention effect of group good, postoperative non-infectious complication is starkly lower than matched group, and obviously can reduce the utilization rate of postoperative analgesia medicine, the incidence rate of the untoward reaction of medicine own is low, illustrates that the present invention has the advantage that untoward reaction is comparatively light, safety is higher being applicable to the preoperative use of anal-surgery.

Claims (1)

1. one kind is applicable to the preoperative preparation method making pharmaceutical composition of anal-surgery, it is characterized in that, crude drug comprises Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Herba Moslae, gelatinum oxhide, Semen Citri Reticulatae, Caulis Trachelospermi, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Bulbus Allii Fistulosi, is made up of following steps:

(1) Semen Citri Reticulatae, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Caulis Trachelospermi coarse powder, Bulbus Allii Fistulosi are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, for subsequent use after the medicinal residues mixing after extraction;

(2) gelatinum oxhide, stir-fried kidney beans are pulverized 150 mesh sieves respectively, become fine powder mixing for standby use;

(3) gained medicinal residues mixing in Herba Bulbophylli inconspicui, Semen corchori, Retinervus Luffae Fructus, nine layers of wind, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 is added 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray is dry, obtains just material;

(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained mixing fine powders mixing in step 2, cross 100 mesh sieves, sterilizing subpackage forms.