CN103705836B - Chinese medicine composition of a kind of improving water flood and preparation method thereof - Google Patents
Chinese medicine composition of a kind of improving water flood and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Chinese medicine composition of a kind of improving water flood and preparation method thereof.Said composition is that raw material is prepared from by medical materials such as Radix Codonopsis, the Radix Astragali, Herba Epimedii, Semen Cuscutae, Fructus Psoraleae, Fructus Corni, the Radix Polygoni Multiflori, Rhizoma Polygonati, Concha Ostreae, Cortex Cinnamomi, Fructus Amomi, Semen Ziziphi Spinosae, Semen Platycladi, panoxadiol's glycosides.Present invention also offers the preparation method of the Chinese medicine composition of this improving water flood.Compositions provided by the invention can extend mice to the length of one's sleep after pentobarbital sodium, and can increase mice to minute sleep rate of 30 after pentobarbital sodium, compared with prior art, the present invention has the function of significance improving water flood.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to Chinese medicine composition of a kind of improving water flood and preparation method thereof.
Background technology
Insomnia is (English: sleeplessness) i.e. sleep disorder.Show as difficulty falling asleep, intermittently discontinuous, and wake up prematurely, can not continue to sleep after waking up again, not have enough sleep, malaise, asthenia be felt.Insomnia is mainly due to environmental factors, and at heart, Nervous and Mental Factors causes, psychological factor as anxiety, dysphoria or depressed, mood is unhappy, is all the major reason causing insomnia.The strike of life, the pressure of work with study, the change etc. of not accomplished wish and social environment, can make people produce psychology and physiological reaction, cause neural dysfunction, cause the dysfunction of brain, just there will be sleep disorder---have a sleepless night.
Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even form the dependence to sleeping medicine, and the sleeping medicine of long-term taking can cause iatrogenic disease.
Expert says that insomnia is called " unable to close the eyes ", " insomnia ", " must not crouch " in "Nei Jing", and thinks that to mainly contain two kinds: one be other disorders affect to insomnia reason, as cough, vomiting, abdominal distention etc., makes people must not peacefully sleeping; Two is that negative and positive of qi and blood is become estranged, and people can not be fallen asleep.
At present, be used for the main selection sleeping pill of Cure for insomnia clinically, as stable.But life-time service sleeping pill, causes human body drug resistance and dependency, meanwhile, has detrimental effect to Liver and kidney.Disease of having a sleepless night position mainly at heart, and relates to liver, spleen, stomach, kidney three are dirty.Therefore, need soothing the liver, spleen invigorating, stomach function regulating, make the normal operation of all functions of body and coordinate, the operation of the gas of yin-Yang is also normal, therefore, reach treating both the principal and the secondary aspects of a disease at the same time, mainly adopt and pacify internal organs for Therapeutic Principle with QI and blood regulating, invigorating the spleen and regulating the stomach, nourishing blood to tranquillize the mind, " promoting circulation of QI-blood makes it reach and make peace flat ", then the sleep of people is also normal.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of improving water flood;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of improving water flood.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition of improving water flood of the present invention is prepared from by the raw material containing following weight portion:
Radix Codonopsis 30-60 part, Radix Astragali 30-60 part, Herba Epimedii 20-40 part, Semen Cuscutae 20-40 part, Fructus Psoraleae 20-40 part, Fructus Corni 20-40 part, Radix Polygoni Multiflori 8-25 part, Rhizoma Polygonati 8-25 part, Concha Ostreae 8-25 part, Cortex Cinnamomi 8-25 part, Fructus Amomi 8-25 part, Semen Ziziphi Spinosae 8-25 part, Semen Platycladi 8-25 part, panoxadiol's glycosides 3-8 part.
Preferably, be prepared from by the raw material containing following weight portion:
Radix Codonopsis 40-50 part, Radix Astragali 40-50 part, Herba Epimedii 25-35 part, Semen Cuscutae 25-35 part, Fructus Psoraleae 25-35 part, Fructus Corni 25-35 part, Radix Polygoni Multiflori 10-20 part, Rhizoma Polygonati 10-20 part, Concha Ostreae 10-20 part, Cortex Cinnamomi 10-20 part, Fructus Amomi 10-20 part, Semen Ziziphi Spinosae 10-20 part, Semen Platycladi 10-20 part, panoxadiol's glycosides 4-6 part.
More preferably, be prepared from by the raw material containing following weight portion:
Radix Codonopsis 45 parts, the Radix Astragali 45 parts, Herba Epimedii 30 parts, Semen Cuscutae 30 parts, Fructus Psoraleae 30 parts, Fructus Corni 30 parts, the Radix Polygoni Multiflori 15 parts, Rhizoma Polygonati 15 parts, Concha Ostreae 15 parts, Cortex Cinnamomi 15 parts, Fructus Amomi 15 parts, Semen Ziziphi Spinosae 15 parts, Semen Platycladi 15 parts, panoxadiol's glycosides 5 parts.
Below crude drug source of the present invention:
Radix Codonopsis: this product is Campanulaceae Radix Codonopsis Codonopsispilosula(Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) CodonopsispilosulaNannf.var.modesta(Nannf.) dry root of L.T.Shen or radix codonpsis tangshen CodonopsistangshenOliv..Autumn excavates, and cleans, dries.[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
The Radix Astragali: be leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) dry root of Bge..Spring, Qiu Erji excavate, and removing fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba Epimedii: this product is Berberidaceae plant Herba Epimedii EpimediumbrevicornumMaxim., Epimedium sagittatum Epimediumsagittatum(Sieb.etZucc.) dry aerial parts of Maxim., E. Pubescens EpimediumpubescensMaxim., Epimedium wushanense EpimediumwushanenseT.S.Ying or Herba Epimedii EpimediumkoreanumNakai.Tap when summer, autumn, stem and leaf was luxuriant, the thick stalk of removing and impurity, dry or dry in the shade.[nature and flavor] acrid, sweet, warm.[return through] returns liver, kidney channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant CuscutachinensisLam..To gather during fruit maturation in autumn plant, dry, lay seed, removing impurity.[nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Psoraleae: this product is the dry mature fruit of legumes psoraleae PsoraleacorylifoliaL..To gather during fruit maturation in autumn infructescence, dry, rub fruit, removing impurity.[nature and flavor] are pungent, bitter, temperature.[return through] returns kidney, spleen channel.[function cures mainly] warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.[usage and dosage] 6 ~ 9g.External 20% ~ 30% tincture is coated with affected part.
Fructus Corni: this product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni CornusofficinalisSieb.etZucc..Picking fruit when time of the year when autumn changes into winter, peel reddened, after drying with slow fire or putting in boiling water and slightly scald, in time except removal core, dry.[nature and flavor] are sour, puckery, tepor.[return through] returns liver, kidney channel.[function cures mainly] liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
The Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb PolygonummultiflorumThunb., and its rattan claims " Caulis Polygoni Multiflori ".Autumn, winter two excavate when season, leaf was withered, two ends of pruning, and clean, individual greatly be cut into block, dry.[nature and flavor] are bitter, sweet, puckery, temperature.[return through] returns liver, the heart, kidney channel.[function cures mainly] detoxifies, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Rhizoma Polygonati: this product is the dry rhizome of liliaceous plant P. kingianum PolygonatumkingianumColl.etHemsl., Rhizoma Polygonati PolygonatumsibiricumRed. or Polygonatum cyrtonema Hua PolygonatumcyrtonemaHua.Different by shape, practise and claim " large Rhizoma Polygonati ", " polygonatum sibiricum Redoute " " RHIZOMA POLYGONATI ZINGIBERIFORME ".Spring, Qiu Erji excavate, and removing fibrous root, cleans, and put in boiling water and slightly scald or steam to the saturating heart, dry.[nature and flavor] are sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Concha Ostreae: this product is the shell of the long Concha Ostreae OstreagigasThunberg of Ostreidae animal, Dalian Bay Concha Ostreae OstreatalienwhanensisCrosse or Crassostrea rivularis OstrearivularisGould.The whole year all can gather, fleshing, cleans, dries.[nature and flavor] are salty, are slightly cold.[return through] returns liver, gallbladder, kidney channel.[function cures mainly] tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi CinnamomumcassiaPresl.Strip more than autumn, dry in the shade.[nature and flavor] are pungent, sweet, hot greatly.[return through] returns kidney, spleen, the heart, Liver Channel.It is supporing yang that [function cures mainly] mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi AmomumvillosumLour., green shell sand AmomumvillosumLour.var.xanthioidesT.L.WuetSenjen or SEMEN AMOMI LONGILIGULA AmomumlongiligulareT.L.Wu.Gather during fruit maturation between summer, autumn, dry or cold drying.[nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Semen Ziziphi Spinosae: this product is Rhamnaceae plant Ziziphi Spinosae ZiziphusjujubaMill.var.spinosa(Bunge) dry mature seed of HuexH.F.Chou.Time of the year when autumn changes into winter gathers mature fruit, removing sarcocarp and nucleocapsid, collects seed, dries.[nature and flavor] are sweet, sour, flat.[return through] returns liver, gallbladder, heart channel.[function cures mainly] tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Semen Platycladi: this product is Cupressaceae plant Cacumen Platycladi Platycladusorientalis(L.) dry mature kernal of Franco.Autumn, mature seed of gathering in season in winter two, dry, and removing seed coat, collects kernel.[nature and flavor] are sweet, flat.[return through] GUIXIN, kidney, large intestine channel.[function cures mainly] tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Panaxadiol saponin: the one being ginsenoside.Ginsenoside (Ginsenoside) is a kind of steroid compound, triterpene saponin.Mainly be present in Araliaceae Panax medical material, Panax's majority is some rare Chinese medicines, as Radix Notoginseng, Radix Ginseng, Radix Panacis Quinquefolii etc.Ginsenoside can be divided into two class three groups according to the difference of sapogenin, and a class is the Dammar methane series saponin of tetracyclic triterpene, and wherein one group of acid hydrolysis end product is panoxadiol, as ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 etc.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, and each extraction time is 1-3 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, obtains described active component.
Scheme two: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, filtrate is condensed into fluid extract, obtains described active component.
Scheme three: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, obtains described active component.
The Chinese medicine composition of improving water flood of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, be dried to dried cream powder, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get one of scheme one to scheme three gained active component, be dried to dried cream powder, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.
Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get one of scheme one to scheme three gained active component, be dried to dried cream powder, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Fang Xie: we's card loses by QI and blood is two, and YANG QI deficiency, deficiency of spleen-YANG and kidneyYANG, caused by lack of preservation of spirit.Overtax one's nerves with controlling to work with one's mind, old asthenia or just recover from a dangerous illness, YANG QI deficiency, asthenia of both the spleen and kidney, disarmony between the heart and kidney institute induced insomnia, drowsiness, deep-thready pulse person.Share as monarch drug with Radix Codonopsis, the Radix Astragali in side, benefiting vital QI and blood, hold concurrently simultaneously and get Central Region with the method for flat benefit, hold up QI of the spleen and stomach with " Zi Huayuan ", can anti-void do not mended.Herba Epimedii, Semen Cuscutae, Fructus Psoraleae warming and recuperating the kidney-YANG, hold concurrently with the supporing yang benefit fire of Cortex Cinnamomi, guiding fire to origin; Fructus Corni tonifying both YIN and YANG, holds concurrently and can assist Fructus Amomi principal drug assistance invigoration spleen qi, the Radix Polygoni Multiflori and Rhizoma Polygonati benefiting vital QI and blood.Above eight taste medicines are ministerial drug altogether, are that negative and positive are assisted mutually, qi and blood tonifying, and the kind YANG invigorating person of lid, must in treating YANG within YIN.Nourish heart latent liver, the method for calming the nerves as assertive evidence takes stopgap measures, Gu Zuo with Concha Ostreae, Semen Ziziphi Spinosae, Semen Platycladi mutual reinforcement between for.In side, the monarch and his subjects control its insomnia originally, and its mark controlled by adjuvant drug, giving consideration to both the incidental and fundamental.
The present invention adds panoxadiol's glycosides on the basis of above-mentioned side, and panoxadiol's glycosides can improve cerebral blood flow, thus improves brain metabolic function, and R wherein
b1there is sedation.Thus, panoxadiol's glycosides can strengthen the health care of our improving water flood, is especially suitable for senile insomnia crowd.
The Chinese medicine composition of a kind of improving water flood provided by the invention has the following advantages:
1, the present invention obviously can extend mice to the length of one's sleep after pentobarbital sodium, significant difference (P < 0.01) compared with blank group; And the present invention is compared with comparative example group, effect is better, there is significant difference (P < 0.05, P < 0.01).
2, the present invention obviously can increase mice to the sleep rate in 30min after pentobarbital sodium, significant difference (P < 0.05, P < 0.01) compared with blank group; And the present invention's effect compared with comparative example group is better, all there is significant difference (P < 0.05, P < 0.01).
3, Traditional Chinese medicine composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.
Embodiment 1 syrup
Get Radix Codonopsis 45g, Radix Astragali 45g, Herba Epimedii 30g, Semen Cuscutae 30g, Fructus Psoraleae 30g, Fructus Corni 30g, Radix Polygoni Multiflori 15g, Rhizoma Polygonati 15g, Concha Ostreae 15g, Cortex Cinnamomi 15g, Fructus Amomi 15g, Semen Ziziphi Spinosae 15g, Semen Platycladi 15g, panoxadiol's glycosides 5g.By above-mentioned whole medical material, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract.In extractum, add syrup adjuvant sucrose, Mel, potassium sorbate, water stirs, obtained syrup.
Embodiment 2 tablet
Get Radix Codonopsis 40g, Radix Astragali 40g, Herba Epimedii 25g, Semen Cuscutae 25g, Fructus Psoraleae 25g, Fructus Corni 25g, Radix Polygoni Multiflori 10g, Rhizoma Polygonati 10g, Concha Ostreae 10g, Cortex Cinnamomi 10g, Fructus Amomi 10g, Semen Ziziphi Spinosae 10g, Semen Platycladi 10g, panoxadiol's glycosides 4g.By above-mentioned whole medical material, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, after filtrate is condensed into fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 mixture
Get Radix Codonopsis 50g, Radix Astragali 50g, Herba Epimedii 35g, Semen Cuscutae 35g, Fructus Psoraleae 35g, Fructus Corni 35g, Radix Polygoni Multiflori 20g, Rhizoma Polygonati 20g, Concha Ostreae 20g, Cortex Cinnamomi 20g, Fructus Amomi 20g, Semen Ziziphi Spinosae 20g, Semen Platycladi 20g, panoxadiol's glycosides 6g.By above-mentioned whole medical material, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filters, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, makes alcohol content be 40%, leave standstill 24 hours, filter, filtrate is condensed into fluid extract, adds 3 times that purified water ad pond om is medical material gross weight, fill, obtains mixture of the present invention.
Add mixture adjuvant sucrose, ethyl ester, water, potassium sorbate stir, obtained mixture.
Embodiment 4 tablet
Get Radix Codonopsis 30g, Radix Astragali 30g, Herba Epimedii 20g, Semen Cuscutae 20g, Fructus Psoraleae 20g, Fructus Corni 20g, Radix Polygoni Multiflori 8g, Rhizoma Polygonati 8g, Concha Ostreae 8g, Cortex Cinnamomi 8g, Fructus Amomi 8g, Semen Ziziphi Spinosae 8g, Semen Platycladi 8g, panoxadiol's glycosides 3g.By above-mentioned whole medical material alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, after filtrate is condensed into fluid extract, be dried to dried cream powder, add microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, micropowder silica gel, obtained tablet.
Embodiment 5 capsule
Get Radix Codonopsis 60g, Radix Astragali 60g, Herba Epimedii 40g, Semen Cuscutae 40g, Fructus Psoraleae 40g, Fructus Corni 30g, Radix Polygoni Multiflori 25g, Rhizoma Polygonati 25g, Concha Ostreae 25g, Cortex Cinnamomi 25g, Fructus Amomi 25g, Semen Ziziphi Spinosae 25g, Semen Platycladi 25g, panoxadiol's glycosides 8g.By above-mentioned whole medical material, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, after filtrate is condensed into fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.
Embodiment 6 granule
Get Radix Codonopsis 60g, Radix Astragali 45g, Herba Epimedii 20g, Semen Cuscutae 20g, Fructus Psoraleae 30g, Fructus Corni 30g, Radix Polygoni Multiflori 20g, Rhizoma Polygonati 15g, Concha Ostreae 15g, Cortex Cinnamomi 8g, Fructus Amomi 25g, Semen Ziziphi Spinosae 15g, Semen Platycladi 15g, panoxadiol's glycosides 3g.By above-mentioned whole medical material, extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filters, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, makes alcohol content be 70%, leave standstill 12 hours, filter, after filtrate is condensed into fluid extract, be dried to dried cream powder, add adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
Embodiment 7 powder
Take Radix Codonopsis 30g, Radix Astragali 60g, Herba Epimedii 25g, Semen Cuscutae 35g, Fructus Psoraleae 30g, Fructus Corni 20g, Radix Polygoni Multiflori 25g, Rhizoma Polygonati 10g, Concha Ostreae 20g, Cortex Cinnamomi 15g, Fructus Amomi 8g, Semen Ziziphi Spinosae 25g, Semen Platycladi 10g, panoxadiol's glycosides 6g.Medical material cleans, pulverize, and crosses 80-100 mesh sieve, obtains powder of the present invention.
Pharmacodynamics test: the evaluation of improving water flood health care
1 experiment material
1.1 animal
Healthy SPF level Kunming mouse, male, body weight 20 ± 2g, buys from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2009-0002).
1.2 tested materials and reagent
Embodiment of the present invention 1-5; Comparative example (melatonin sheet); Pentobarbital sodium (sigma).
2 extend the pentobarbital sodium experiment length of one's sleep
2.1 grouping with give sample
Mice adaptability feeds 3d, gets 84 mices, is divided into blank group, comparative example group, embodiment 1-5 group at random, often organizes 12 mices.Carry out gavage to sample by following dosage: embodiment group dosage is 3.0g/kg/d by crude drug gauge, contrast groups dosage is 0.5mg/kg/d, and blank group gives isometric(al) distilled water, 0.2mL/10g, 1 time/d, continuous 30d.
2.2 method
Last is to after sample 15min, and each group mouse peritoneal injects 50mg/kg pentobarbital sodium, and injection volume is 0.2mL/20g, with righting reflex loss (when mice is placed in supine position, can not the person of righting in 60s, namely think righting reflex loss) be index, observe the length of one's sleep.Variance analysis is adopted to add up.
2.3 result
Table 1. is on the impact extending the pentobarbital sodium length of one's sleep
Note: compare with blank group, * * P < 0.01; Compare with comparative example group,
#p < 0.05,
##p < 0.01.
Table 1 result shows, and embodiment 1-5 group and comparative example group be energy obviously Sleeping Time Prolong Ed all, significant difference (P < 0.01) compared with blank group; And embodiment 1-5 group is compared with comparative example group, all there is significant difference (P < 0.05, P < 0.01).
3 pentobarbital sodium sub-threshold lull dosage experiments
3.1 grouping with give sample
Get 140 mices, be divided into blank group, comparative example group, embodiment 1-5 group at random, often organize 20, gavage is carried out to sample: embodiment group dosage is 3.0g/kg/d by crude drug gauge by following dosage, contrast groups dosage is 0.5mg/kg/d, and blank group gives isometric(al) distilled water, 0.2mL/10g, 1 time/d, continuous 30d.
3.2 method
Last is to after sample 15min, and the maximum subthreshold hypnotic dosage of each group mouse peritoneal injection 30mg/kg pentobarbital sodium, injection volume is 0.2mL/20g, observes in 30min (the above person of righting reflex loss 1min) number of mice of falling asleep.
3.3 result
Table 2. is on the impact of pentobarbital sodium sub-threshold lull dosage experiment mice
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with comparative example group,
#p < 0.05,
##p < 0.01.
Table 2 result shows, and embodiment 1-5 group and comparative example group all obviously can increase the sleep rate of mice in 30min, significant difference (P < 0.05, P < 0.01) compared with blank group; And embodiment 1-5 group is compared with comparative example group, all there is significant difference (P < 0.05, P < 0.01).
Conclusion: the present invention can extend mice to the length of one's sleep after pentobarbital sodium, can increase mice to minute sleep rate of 30 after pentobarbital sodium, compared with prior art, the present invention has the function of significance improving water flood.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. a Chinese medicine composition for improving water flood, is characterized in that it is prepared from by the raw material of following weight portion: Radix Codonopsis 30-60 part, Radix Astragali 30-60 part, Herba Epimedii 20-40 part, Semen Cuscutae 20-40 part, Fructus Psoraleae 20-40 part, Fructus Corni 20-40 part, Radix Polygoni Multiflori 8-25 part, Rhizoma Polygonati 8-25 part, Concha Ostreae 8-25 part, Cortex Cinnamomi 8-25 part, Fructus Amomi 8-25 part, Semen Ziziphi Spinosae 8-25 part, Semen Platycladi 8-25 part, panoxadiol's glycosides 3-8 part.
2. the Chinese medicine composition of improving water flood as claimed in claim 1, is characterized in that it is prepared from by the raw material of following weight portion: Radix Codonopsis 40-50 part, Radix Astragali 40-50 part, Herba Epimedii 25-35 part, Semen Cuscutae 25-35 part, Fructus Psoraleae 25-35 part, Fructus Corni 25-35 part, Radix Polygoni Multiflori 10-20 part, Rhizoma Polygonati 10-20 part, Concha Ostreae 10-20 part, Cortex Cinnamomi 10-20 part, Fructus Amomi 10-20 part, Semen Ziziphi Spinosae 10-20 part, Semen Platycladi 10-20 part, panoxadiol's glycosides 4-6 part.
3. the Chinese medicine composition of improving water flood as claimed in claim 1, is characterized in that it is prepared from by the raw material of following weight portion: Radix Codonopsis 45 parts, the Radix Astragali 45 parts, Herba Epimedii 30 parts, Semen Cuscutae 30 parts, Fructus Psoraleae 30 parts, Fructus Corni 30 parts, the Radix Polygoni Multiflori 15 parts, Rhizoma Polygonati 15 parts, Concha Ostreae 15 parts, Cortex Cinnamomi 15 parts, Fructus Amomi 15 parts, Semen Ziziphi Spinosae 15 parts, Semen Platycladi 15 parts, panoxadiol's glycosides 5 parts.
4. the Chinese medicine composition as described in claim 1-3 any one, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, filtrate is condensed into fluid extract, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
8. a Chinese medicine composition for improving water flood, in the Chinese medicine composition of the improving water flood any one of claim 1-3 and pharmaceuticals industry, acceptable carrier prepares and forms.
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