CN103705836A - Traditional Chinese medicine composition for improving sleep and preparation method thereof - Google Patents
Traditional Chinese medicine composition for improving sleep and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for improving sleep and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: Codonopsis pilosula, Astragalus root, herba epimedii, semen cuscutae, fructus psoraleae, dogwood, multiflower knotweed root, rhizoma polygonati, oyster, cinnamon, fructus amomi, spina date seed, semen boitae, panaxadiol saponins and other medicinal materials. The invention also provides a preparation method of the traditional Chinese medicine composition for improving sleep. The traditional Chinese medicine composition can prolong the sleeping time of mice dosed by pentobarbital sodium, and can increase the rate of going to sleep, within 30 minutes, of the mice dosage by the pentobarbital sodium, and compared with the prior art, the traditional Chinese medicine composition has an effect on improving the sleep remarkably.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of Chinese medicine composition that improves sleep and preparation method thereof.
Background technology
Insomnia (English: sleeplessness) be sleep disorder.Show as difficulty falling asleep, intermittently discontinuous, and wake up prematurely, after waking up, can not continue again to sleep, do not have enough sleep, malaise, asthenia sensation.Insomnia is mainly due to environmental factors, at heart, Nervous and Mental Factors causes, psychological factor as anxiety, dysphoria or depressed, mood is unhappy etc., is all the major reason that causes insomnia.The pressure of the strike of life, work and study, not accomplished wish and the variation of social environment etc., can make people produce psychology and physiological reaction, causes neural dysfunction, causes the dysfunction of brain, just there will be sleep disorder---insomnia.
Insomnia is one of common clinical disease, though do not belong to critical illness, hinders people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia, brings long-term misery to patient, even forms the dependence to the medicine of sleeping peacefully, and long-term taking is slept peacefully, medicine can cause iatrogenic disease.
Expert says that insomnia is called " unable to close the eyes ", " insomnia ", " must not crouch " in < < in > >, and think that insomnia reason mainly contains two kinds: the one, other disease impacts, as cough, vomiting, abdominal distention etc., make the people must not peacefully sleeping; The 2nd, negative and positive of qi and blood is become estranged, and people can not be fallen asleep.
At present, be used for clinically the main selection sleeping pill of Cure for insomnia, as stable.Yet life-time service sleeping pill, causes human body drug resistance and dependency, meanwhile, Liver and kidney is had to detrimental effect.The sick position of insomnia is mainly at heart, and it is dirty to relate to liver, spleen, stomach, kidney three.Therefore, need to be soothing the liver, spleen invigorating, stomach function regulating, makes normal operation and the coordination of all functions of body, and the operation of the gas of yin-Yang is also normal, therefore, reach treating both the principal and the secondary aspects of a disease at the same time, main employing be take QI and blood regulating and is pacified internal organs as Therapeutic Principle, invigorating the spleen and regulating the stomach, nourishing blood to tranquillize the mind, " promoting circulation of QI-blood makes it reach and makes peace flat ", people's sleep is also normal.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition that improves sleep;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of improving sleep.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition of improvement sleep of the present invention is to be prepared from by the raw material containing following weight portion:
Radix Codonopsis 30-60 part, Radix Astragali 30-60 part, Herba Epimedii 20-40 part, Semen Cuscutae 20-40 part, Fructus Psoraleae 20-40 part, Fructus Corni 20-40 part, Radix Polygoni Multiflori 8-25 part, Rhizoma Polygonati 8-25 part, Concha Ostreae 8-25 part, Cortex Cinnamomi 8-25 part, Fructus Amomi 8-25 part, Semen Ziziphi Spinosae 8-25 part, Semen Platycladi 8-25 part, panoxadiol's glycosides 3-8 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Radix Codonopsis 40-50 part, Radix Astragali 40-50 part, Herba Epimedii 25-35 part, Semen Cuscutae 25-35 part, Fructus Psoraleae 25-35 part, Fructus Corni 25-35 part, Radix Polygoni Multiflori 10-20 part, Rhizoma Polygonati 10-20 part, Concha Ostreae 10-20 part, Cortex Cinnamomi 10-20 part, Fructus Amomi 10-20 part, Semen Ziziphi Spinosae 10-20 part, Semen Platycladi 10-20 part, panoxadiol's glycosides 4-6 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
45 parts of Radix Codonopsis, 45 parts of the Radixs Astragali, 30 parts of Herba Epimedii, 30 parts of Semen Cuscutae, 30 parts of Fructus Psoraleaes, 30 parts of Fructus Corni, 15 parts of the Radixs Polygoni Multiflori, 15 parts of Rhizoma Polygonatis, 15 parts of Concha Ostreaes, 15 parts of Cortex Cinnamomis, 15 parts of Fructus Amomis, 15 parts of Semen Ziziphi Spinosaes, 15 parts of Semen Platycladi, 5 parts of panoxadiol's glycosides.
Below crude drug source of the present invention:
Radix Codonopsis: this product is Campanulaceae Radix Codonopsis Codonopsis pilosula(Franch.) Nannf., element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) Codonopsis pilosula Nannf.var.modesta(Nannf.) dry root of L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Excavate autumn, cleans, and dries.[nature and flavor] are sweet, flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
The Radix Astragali: be leguminous plant Radix Astagali Astragalus membranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalus membranaceus(Fisch.) dry root of Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Herba Epimedii: this product is Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum(Sieb.et Zucc.) dry aerial parts of Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.When summer, autumn, stem and leaf was luxuriant, tap, remove thick stalk and impurity, dry or dry in the shade.[nature and flavor] acrid, sweet, warm.[return through] returns liver, kidney channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..The plant of gathering during fruit maturation autumn, dries, and lays seed, removes impurity.[nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Psoraleae: this product is the dry mature fruit of legumes psoraleae Psoralea corylifolia L..The infructescence of gathering during fruit maturation autumn, dries, and rubs fruit, removes impurity.[nature and flavor] are pungent, bitter, temperature.[return through] returns kidney, spleen channel.[function cures mainly] warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.[usage and dosage] 6～9g.External 20%～30% tincture is coated with affected part.
Fructus Corni: this product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et Zucc..The picking fruit when time of the year when autumn changes into winter, peel reddened, after drying or put and slightly scald in boiling water with slow fire, in time except removal core, dry.[nature and flavor] acid, puckery, tepor.[return through] returns liver, kidney channel.[function cures mainly] liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.Interior-heat is quenched one's thirst.
The Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., and its rattan claims " Caulis Polygoni Multiflori ".Autumn, two season of winter excavate when leaf is withered, and the two ends of pruning are cleaned, and the individual large piece that is cut into is dry.[nature and flavor] are bitter, sweet, puckery, temperature.[return through] returns liver, the heart, kidney channel.[function cures mainly] removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Rhizoma Polygonati: this product is the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Different by shape, practise and claim " large Rhizoma Polygonati ", " polygonatum sibiricum Redoute " " RHIZOMA POLYGONATI ZINGIBERIFORME ".Spring, Qiu Erji excavate, and remove fibrous root, clean, and put slightly boiling hot in boiling water or steam the heart extremely thoroughly, dry.[nature and flavor] are sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Concha Ostreae: this product is the shell of the long Concha Ostreae Ostrea of Ostreidae animal gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrea rivularis Gould.All can gather the whole year, and fleshing is cleaned, and dries.[nature and flavor] are salty, are slightly cold.[return through] returns liver, gallbladder, kidney channel.[function cures mainly] tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.The insomnia that is used for palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.More than stripping autumn, dry in the shade.[nature and flavor] are pungent, sweet, hot greatly.[return through] returns kidney, spleen, the heart, Liver Channel.It is supporing yang that [function cures mainly] mends fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, and conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Fructus Amomi: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi Amomum villosum Lour., green shell sand Amomum villosum Lour.var.xanthioides T.L.Wu et Senjen or SEMEN AMOMI LONGILIGULA Amomum longiligulare T.L.Wu.Between summer, autumn, gather during fruit maturation, dry or cold drying.[nature and flavor] are pungent, temperature.[return through] returns spleen, stomach, kidney channel.[function cures mainly] removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Semen Ziziphi Spinosae: this product is Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba Mill.var.spinosa(Bunge) dry mature seed of Hu ex H.F.Chou.The time of the year when autumn changes into winter mature fruit of gathering, removes sarcocarp and nucleocapsid, collects seed, dries.[nature and flavor] are sweet, sour, flat.[return through] returns liver, gallbladder, heart channel.[function cures mainly] tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Semen Platycladi: this product is Cupressaceae plant Cacumen Platycladi Platycladus orientalis(L.) dry mature kernal of Franco.The mature seed of gathering in autumn, two seasons of winter, dries, and removes kind of a skin, collects kernel.[nature and flavor] are sweet, flat.[return through] GUIXIN, kidney, large intestine channel.[function cures mainly] tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Panaxadiol saponin: be a kind of of ginsenoside.Ginsenoside (Ginsenoside) is a kind of steroid compound, triterpene saponin.Mainly be present in Araliaceae Panax medical material, Panax's majority is some rare Chinese medicines, as Radix Notoginseng, Radix Ginseng, Radix Panacis Quinquefolii etc.Ginsenoside can be divided into three groups of two classes according to the difference of sapogenin, and a class is the Dammar methane series saponin of tetracyclic triterpene, and wherein one group of acid hydrolysis end product is panoxadiol, as ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 etc.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, and each extraction time is 1-3 hour, and merge extractive liquid, filters, and filtrate is condensed into fluid extract, obtains described active component.
Scheme two: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, and standing 12-24 hour filters, filtrate is condensed into fluid extract, obtains described active component.
Scheme three: get whole medical materials, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 1-3 hour to the 4-10 that each ethanol consumption is medical material total amount, and merge extractive liquid,, filters, and filtrate is condensed into fluid extract, obtains described active component.
The Chinese medicine composition of improvement sleep of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add granule to commonly use adjuvant, production method is prepared into granule of the present invention routinely.
The conventional adjuvant of above-mentioned granule comprises one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active component, be dried to dried cream powder, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
Side separates: we's card loses by QI and blood is two, YANG QI deficiency, and deficiency of spleen-YANG and kidneyYANG, due to lack of preservation of spirit.With controlling to work with one's mind, overtax one's nerves, old asthenia or just recover from a dangerous illness, YANG QI deficiency, asthenia of both the spleen and kidney, disarmony between the heart and kidney institute induced insomnia, drowsiness, deep-thready pulse person.In side, take Radix Codonopsis, the Radix Astragali shares as monarch drug, and benefiting vital QI and blood, holds concurrently and get Central Region to equal the method for benefit simultaneously, holds up QI of the spleen and stomach with " Zi Huayuan ", can anti-void not mended.Herba Epimedii, Semen Cuscutae, Fructus Psoraleae warming and recuperating the kidney-YANG, hold concurrently with the supporing yang benefit fire of Cortex Cinnamomi, guiding fire to origin; Fructus Corni tonifying both YIN and YANG, holds concurrently and can assist Fructus Amomi principal drug assistance invigoration spleen qi, the Radix Polygoni Multiflori and Rhizoma Polygonati benefiting vital QI and blood.Above eight taste medicines are ministerial drug altogether, are that negative and positive are assisted mutually, qi and blood tonifying, and the kind YANG invigorating person of lid, must be in treating YANG within YIN.The method that nourishes heart and dive liver, calm the nerves and take stopgap measures for assertive evidence, it is use that Gu Zuo be take Concha Ostreae, Semen Ziziphi Spinosae, Semen Platycladi mutual reinforcement between.In side, the monarch and his subjects control its insomnia originally, and adjuvant drug is controlled its mark, giving consideration to both the incidental and fundamental.
The present invention adds panoxadiol's glycosides on above-mentioned side's basis, and panoxadiol's glycosides can improve brain blood flow, thereby improves brain metabolic function, and R wherein
b1there is sedation.Thereby panoxadiol's glycosides can be strengthened the health care that we improve sleep, is especially suitable for senile insomnia crowd.
A kind of Chinese medicine composition that improves sleep provided by the invention has the following advantages:
1, the present invention can obviously extend mice to pentobarbital sodium after the length of one's sleep, compare significant difference (P < 0.01) with blank group; And the present invention compares with comparative example group, and effect is better, there is significant difference (P < 0.05, P < 0.01).
2, the present invention can obviously increase mice to pentobarbital sodium after the rate of falling asleep in 30min, compare significant difference (P < 0.05, P < 0.01) with blank group; And it is better that the present invention and comparative example group are compared effect, all has significant difference (P < 0.05, P < 0.01).
3, Chinese medicine composition composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
Embodiment 1 syrup
Get Radix Codonopsis 45g, Radix Astragali 45g, Herba Epimedii 30g, Semen Cuscutae 30g, Fructus Psoraleae 30g, Fructus Corni 30g, Radix Polygoni Multiflori 15g, Rhizoma Polygonati 15g, Concha Ostreae 15g, Cortex Cinnamomi 15g, Fructus Amomi 15g, Semen Ziziphi Spinosae 15g, Semen Platycladi 15g, panoxadiol's glycosides 5g.By above-mentioned whole medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, and merge extractive liquid, filters, and filtrate is condensed into fluid extract.In extractum, add syrup adjuvant sucrose, Mel, potassium sorbate, water to stir, make syrup.
Embodiment 2 tablets
Get Radix Codonopsis 40g, Radix Astragali 40g, Herba Epimedii 25g, Semen Cuscutae 25g, Fructus Psoraleae 25g, Fructus Corni 25g, Radix Polygoni Multiflori 10g, Rhizoma Polygonati 10g, Concha Ostreae 10g, Cortex Cinnamomi 10g, Fructus Amomi 10g, Semen Ziziphi Spinosae 10g, Semen Platycladi 10g, panoxadiol's glycosides 4g.By above-mentioned whole medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 3 mixture
Get Radix Codonopsis 50g, Radix Astragali 50g, Herba Epimedii 35g, Semen Cuscutae 35g, Fructus Psoraleae 35g, Fructus Corni 35g, Radix Polygoni Multiflori 20g, Rhizoma Polygonati 20g, Concha Ostreae 20g, Cortex Cinnamomi 20g, Fructus Amomi 20g, Semen Ziziphi Spinosae 20g, Semen Platycladi 20g, panoxadiol's glycosides 6g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filters, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.20, adds ethanol, and making containing alcohol amount is 40%, standing 24 hours, filter, filtrate is condensed into fluid extract, and adding purified water ad pond om is 3 times of medical material gross weight, fill, obtains mixture of the present invention.
Add mixture adjuvant sucrose, ethyl ester, water, potassium sorbate to stir, make mixture.
Embodiment 4 tablets
Get Radix Codonopsis 30g, Radix Astragali 30g, Herba Epimedii 20g, Semen Cuscutae 20g, Fructus Psoraleae 20g, Fructus Corni 20g, Radix Polygoni Multiflori 8g, Rhizoma Polygonati 8g, Concha Ostreae 8g, Cortex Cinnamomi 8g, Fructus Amomi 8g, Semen Ziziphi Spinosae 8g, Semen Platycladi 8g, panoxadiol's glycosides 3g.By above-mentioned whole medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, and merge extractive liquid, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, micropowder silica gel, make tablet.
Embodiment 5 capsules
Get Radix Codonopsis 60g, Radix Astragali 60g, Herba Epimedii 40g, Semen Cuscutae 40g, Fructus Psoraleae 40g, Fructus Corni 30g, Radix Polygoni Multiflori 25g, Rhizoma Polygonati 25g, Concha Ostreae 25g, Cortex Cinnamomi 25g, Fructus Amomi 25g, Semen Ziziphi Spinosae 25g, Semen Platycladi 25g, panoxadiol's glycosides 8g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, and merge extractive liquid, filters, filtrate is condensed into after fluid extract, be dried to dried cream powder, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 6 granules
Get Radix Codonopsis 60g, Radix Astragali 45g, Herba Epimedii 20g, Semen Cuscutae 20g, Fructus Psoraleae 30g, Fructus Corni 30g, Radix Polygoni Multiflori 20g, Rhizoma Polygonati 15g, Concha Ostreae 15g, Cortex Cinnamomi 8g, Fructus Amomi 25g, Semen Ziziphi Spinosae 15g, Semen Platycladi 15g, panoxadiol's glycosides 3g.By above-mentioned whole medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, and merge extractive liquid, filters, filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, adds ethanol, and making containing alcohol amount is 70%, standing 12 hours, filter, filtrate is condensed into after fluid extract, is dried to dried cream powder, add adjuvant Icing Sugar, starch, dextrin, ethanol, make granule.
Embodiment 7 powder
Take Radix Codonopsis 30g, Radix Astragali 60g, Herba Epimedii 25g, Semen Cuscutae 35g, Fructus Psoraleae 30g, Fructus Corni 20g, Radix Polygoni Multiflori 25g, Rhizoma Polygonati 10g, Concha Ostreae 20g, Cortex Cinnamomi 15g, Fructus Amomi 8g, Semen Ziziphi Spinosae 25g, Semen Platycladi 10g, panoxadiol's glycosides 6g.Medical material cleans, pulverizes, and crosses 80-100 mesh sieve, obtains powder of the present invention.
Pharmacodynamics test: improve the evaluation of sleep health function
1 experiment material
1.1 animal
Healthy SPF level Kunming mouse, male, body weight 20 ± 2g, buys from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2009-0002).
1.2 tested materials and reagent
Embodiment of the present invention 1-5; Comparative example (melatonin sheet); Pentobarbital sodium (sigma).
2 extend the pentobarbital sodium experiment length of one's sleep
2.1 groupings with give sample
Mice adaptability is fed 3d, gets 84 mices, is divided at random blank group, comparative example group, embodiment 1-5 group, every group of 12 mices.By following dosage, carry out gavage to sample: embodiment group dosage is counted 3.0g/kg/d by crude drug amount, and contrast groups dosage is 0.5mg/kg/d, and blank group gives isometric(al) distilled water, 0.2mL/10g, 1 time/d, 30d continuously.
2.2 method
Last to sample 15min after, each organizes mouse peritoneal injection 50mg/kg pentobarbital sodium, injection volume is 0.2mL/20g, with righting reflex loss (when mice is placed in supine position, can not the person of righting in 60s, think righting reflex loss) be index, observe the length of one's sleep.Adopt variance analysis to add up.
2.3 result
Table 1. is on extending the pentobarbital sodium impact of the length of one's sleep
Note: with the comparison of blank group, * * P < 0.01; With the comparison of comparative example group,
#p < 0.05,
##p < 0.01.
The demonstration of table 1 result, embodiment 1-5 group and comparative example group be the obvious Sleeping Time Prolong Ed of energy all, compares significant difference (P < 0.01) with blank group; And embodiment 1-5 group is compared with comparative example group, all there is significant difference (P < 0.05, P < 0.01).
3 pentobarbital sodium sub-threshold lull dosage experiments
3.1 groupings with give sample
Get 140 mices, be divided at random blank group, comparative example group, embodiment 1-5 group, every group 20, by following dosage, carry out gavage to sample: embodiment group dosage is counted 3.0g/kg/d by crude drug amount, contrast groups dosage is 0.5mg/kg/d, and blank group gives isometric(al) distilled water, 0.2mL/10g, 1 time/d, continuous 30d.
3.2 method
Last to sample 15min after, each organizes the maximum subthreshold hypnotic dosage of mouse peritoneal injection 30mg/kg pentobarbital sodium, injection volume is 0.2mL/20g, observes (the above person of the righting reflex loss 1min) number of mice of falling asleep in 30min.
3.3 result
The impact of table 2. on pentobarbital sodium sub-threshold lull dosage experiment mice
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01; With the comparison of comparative example group,
#p < 0.05,
##p < 0.01.
The demonstration of table 2 result, embodiment 1-5 group and comparative example group all can obviously increase the fall asleep rate of mice in 30min, compare significant difference (P < 0.05, P < 0.01) with blank group; And embodiment 1-5 group is compared with comparative example group, all there is significant difference (P < 0.05, P < 0.01).
Conclusion: the present invention can extend mice to pentobarbital sodium after the length of one's sleep, can increase by 30 minute the fall asleep rates of mice after to pentobarbital sodium, compared with prior art, the present invention has the function that significance improves sleep.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. improve a Chinese medicine composition for sleep, it is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Codonopsis 30-60 part, Radix Astragali 30-60 part, Herba Epimedii 20-40 part, Semen Cuscutae 20-40 part, Fructus Psoraleae 20-40 part, Fructus Corni 20-40 part, Radix Polygoni Multiflori 8-25 part, Rhizoma Polygonati 8-25 part, Concha Ostreae 8-25 part, Cortex Cinnamomi 8-25 part, Fructus Amomi 8-25 part, Semen Ziziphi Spinosae 8-25 part, Semen Platycladi 8-25 part, panoxadiol's glycosides 3-8 part.
2. the Chinese medicine composition of improvement sleep as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Codonopsis 40-50 part, Radix Astragali 40-50 part, Herba Epimedii 25-35 part, Semen Cuscutae 25-35 part, Fructus Psoraleae 25-35 part, Fructus Corni 25-35 part, Radix Polygoni Multiflori 10-20 part, Rhizoma Polygonati 10-20 part, Concha Ostreae 10-20 part, Cortex Cinnamomi 10-20 part, Fructus Amomi 10-20 part, Semen Ziziphi Spinosae 10-20 part, Semen Platycladi 10-20 part, panoxadiol's glycosides 4-6 part.
3. the Chinese medicine composition of improvement sleep as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 45 parts of Radix Codonopsis, 45 parts of the Radixs Astragali, 30 parts of Herba Epimedii, 30 parts of Semen Cuscutae, 30 parts of Fructus Psoraleaes, 30 parts of Fructus Corni, 15 parts of the Radixs Polygoni Multiflori, 15 parts of Rhizoma Polygonatis, 15 parts of Concha Ostreaes, 15 parts of Cortex Cinnamomis, 15 parts of Fructus Amomis, 15 parts of Semen Ziziphi Spinosaes, 15 parts of Semen Platycladi, 5 parts of panoxadiol's glycosides.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, standing 12-24 hour, filter, filtrate is condensed into fluid extract, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get whole medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains described active component.
8. improve a Chinese medicine composition for sleep, comprise acceptable carrier in the Chinese medicine composition of improvement sleep of any one in claim 1-3 and pharmaceuticals industry.
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| CN105687564A (en) * | 2016-02-23 | 2016-06-22 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for improving sleep and memory and preparation method of traditional Chinese medicine composition for improving sleep and memory |
| CN108030099A (en) * | 2017-12-29 | 2018-05-15 | 广州硕维食品技术有限公司 | It is a kind of effectively to relieve stress the prescription nutrition food and preparation method for improving sleep |
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| CN103405716A (en) * | 2013-08-08 | 2013-11-27 | 谢春红 | Herbal decoction for treating insomnia |
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| 高尚社: "中医药治疗失眠近况", 《中国中医药现代远程教育》 * |
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| CN105687564A (en) * | 2016-02-23 | 2016-06-22 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for improving sleep and memory and preparation method of traditional Chinese medicine composition for improving sleep and memory |
| CN108030099A (en) * | 2017-12-29 | 2018-05-15 | 广州硕维食品技术有限公司 | It is a kind of effectively to relieve stress the prescription nutrition food and preparation method for improving sleep |
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