CN104027342A - Medicinal composition for preventing and treating fur animal mites - Google Patents
Medicinal composition for preventing and treating fur animal mites Download PDFInfo
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- CN104027342A CN104027342A CN201410179344.3A CN201410179344A CN104027342A CN 104027342 A CN104027342 A CN 104027342A CN 201410179344 A CN201410179344 A CN 201410179344A CN 104027342 A CN104027342 A CN 104027342A
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Abstract
The invention relates to a medicinal conjugate for preventing and treating fur animal mites. The medicinal conjugate includes emamectin, flumethrin, amitraz and optional traditional Chinese medicinal extracts. The mixed application of active components with different action mechanisms and different control spectrums can prevent or delay the development of the drug resistance of mites, prolongs the effective periods of insecticides, and realizes a synergistic effect. The invention also relates to a medicinal combination of the conjugate. The medicinal composition can be a spray or an ointment.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of active constituents of medicine conjugate and pharmaceutical composition of preventing and treating fur-bearing animal body demodicid mite.
Background technology
Fur-bearing animal body acaricide is that evil demodicid mite parasitizes animal body surface and the chronic epizootic disease of a kind of animal that causes, causes that the main pathogen of body acaricide evil mainly comprises acaricide, itch mite, vermiform mite, sufficient demodicid mite, ear demodicid mite etc.When this disease occurs animal, main manifestations is violent pruritus, appetite depression, becomes thin, by hair, is come off etc., has a strong impact on fertility performance and the economic worth of animal, and then affects the development of animal husbandry.
At present, the medicine of relevant control and/or treatment animal body demodicid mite has a lot, comprises organic phosphates, chrysanthemum esters and Chinese medicine extract etc., and the patent application of this aspect is also not within minority:
CN101879176A discloses a kind of injection for mite infection of dog, wherein consisting of of every 100L injection: ivermectin 0.001～0.5kg, and chlorphenamine maleate 0.05～0.5kg, dimethyl acetylamide 5～30L, surplus is propylene glycol.It adopts ivermectin as the main component of killing acarid.
CN103070960A discloses a kind of external used medicine liniment for the treatment of equus acaricide, its composition comprises Cortex Pseudolaricis 30-50 part, Cortex Hibisci 20-40 part, Radix Rumicis 20-40 part, Radix Sophorae Flavescentis 20-40 part, Spina Gleditsiae 20-40 part, Fructus Cnidii 20-40 part, Cortex Ailanthi 20-40 part, Cortex Phellodendri 15-25 part, Radix Angelicae Dahuricae 15-25 part, Realgar 15-25 part, sulfur 15-25 part, catechu 15-25 part, salicylic acid powder 5-15 part, and its active component mainly be take Chinese medicine as main.
CN102784166A discloses a kind of compound ivermectin compositions for the treatment of domestic animal acariasis, by following component by weight mixed preparing form: ivermectin 0.5-1.0 part, sulfur 15-25 part, propylene glycol 50-70 part, stearic acid 10-30 part, ethanol 10-30 part.
CN103385927A discloses a kind of Chinese medicine composition for the treatment of animal acaricide, comprises each component of following mass fraction: 180～250 parts, blue flower side gold small cup, 220～300 parts of Flos Caryophyllis, 180～250 parts of Cortex Pseudolariciss, 120～200 parts of Radix Sophorae Flavescentiss.Its active component mainly be take Chinese medicine as main.
Yet organophosphor medicine toxicity is larger, chrysanthemum esters medicine easily produces resistance, and Chinese medicine extract composition drug effect is slower; And as everyone knows, the drug effect of single-activity composition medicine is poor and easily bring out harmful demodicid mite generation resistance, therefore has a kind of demand that can effectively prevent and treat fur-bearing animal body demodicid mite and be difficult for bringing out the medicine of harmful demodicid mite resistance.
Summary of the invention
The present invention aims to provide a kind of active ingredient combination and the preparation compositions thereof that can effectively prevent and treat fur-bearing animal body demodicid mite, described conjugate and/or compositions epidermis penetration are strong, Synergistic, can effectively prevent and treat the harmful demodicid mite of fur-bearing animal skin surface, and toxicity is low and be difficult for bringing out harmful demodicid mite and produce resistance.
In order to achieve the above object, the present invention adopts following technical scheme.
One aspect of the present invention relates to a kind of drug conjugates of preventing and treating fur-bearing animal body demodicid mite, and it comprises following component and weight portion thereof:
Emaricin 10-20 part
Flumethrin 5-15 part
Amitraz 5-10 part.
Preferably, each component and weight portion thereof are:
Emaricin 12-16 part
Flumethrin 8-12 part
Amitraz 6-8 part.
Further preferred, each component and weight portion thereof are:
15 parts of emaricins
10 parts of flumethrins
8 parts of Amitrazs.
In one embodiment of the invention, described conjugate also comprises Chinese medicine extract, and wherein each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
Radix Sophorae Flavescentis 1-5 part, Realgar 2-8 part, Fructus Cnidii 5-8 part, Herba Plantaginis 2-5 part, Radix Glycyrrhizae 3-6 part, Herba Andrographis 2-4 part, Radix Angelicae Dahuricae 6-9 part, Fructus Kochiae 3-7 part.
Preferably, each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
Radix Sophorae Flavescentis 2-4 part, Realgar 4-6 part, Fructus Cnidii 6-8 part, Herba Plantaginis 2-4 part, Radix Glycyrrhizae 4-5 part, Herba Andrographis 3-4 part, Radix Angelicae Dahuricae 7-8 part, Fructus Kochiae 4-6 part.
Further preferred, each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
3 parts of Radix Sophorae Flavescentiss, 5 parts of Realgars, 7 parts of Fructus Cnidiis, 3 parts of Herba Plantaginis, 4 parts, Radix Glycyrrhizae, 3 parts of Herba Andrographis, 7 parts of the Radixs Angelicae Dahuricae, 5 parts of the Fructus Kochiae.
In above-mentioned formula, the extracting method of described Chinese medicine extract is:
The Chinese medicinal components of formula ratio is pulverized, is then used 55-70%, preferably 65% alcohol dipping 30-50 hour, preferred 40-45 hour, during jolting or stir 2-3 time; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 2-3 time again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be described Chinese medicine extract.
In active ingredient combination of the present invention, the active component of different mechanism of action, different control spectrums is mixed to application, can prevent or delay the resistance development of body demodicid mite to medicine on the one hand, on the other hand, because each composition mechanism of action is not quite similar, after combination, the prevention effect of body demodicid mite is better than to each single dose, Synergistic.
Preferably, in above-mentioned formula, add Chinese medicine ingredients, can further prevent or delay on the one hand body demodicid mite resistance and produce; On the other hand, active ingredient of Chinese herbs can form the complementation of action effect with Western medicine chemical composition, reduce the use of Western medicine chemical composition, extends the medicament lasting period etc.
The present invention relates to a kind of pharmaceutical composition of preventing and treating fur-bearing animal body demodicid mite on the other hand, it is characterized in that, described pharmaceutical composition be take above-mentioned conjugate as active component, and described pharmaceutical composition is prepared into spray or ointment.
Preferably, described pharmaceutical composition is prepared into ointment, wherein each component and weight portion thereof are as follows:
Aforementioned arbitrary drug conjugates 5-40 part
Penetrating agent 2-30 part
Substrate 20-100 part;
Wherein, described penetrating agent is selected from one or more in trisiloxane ethoxylate, trisiloxanes polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, sodium lauryl sulphate;
Described substrate is selected from glycerol, lanoline or liquid paraffin.
Further preferred, each component and weight portion thereof are:
Aforementioned arbitrary drug conjugates 10-30 part
Penetrating agent 5-20 part
Substrate 40-80 part;
Wherein, described penetrating agent is selected from one or more in trisiloxane ethoxylate, trisiloxanes polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, sodium lauryl sulphate;
Described substrate is selected from glycerol, lanoline or liquid paraffin.
In further preferred embodiment, in described pharmaceutical composition, each component and weight portion thereof are preferred:
20 parts of aforementioned arbitrary described drug conjugates
10 parts of penetrating agent
60 parts of substrate
Wherein, described penetrating agent is selected from trisiloxanes polyoxyethylene ether and sodium lauryl sulphate, and the weight ratio of the two is 1:1;
Described substrate is selected from glycerol.
In above-mentioned composition, adding of penetrating agent can help active component to infiltrate effectively and rapidly cortex, and this contributes to the performance of drug effect, effectively prevents and treats body demodicid mite.Consider that active component of the present invention is as the physicochemical property of emaricin, flumethrin and Amitraz etc. and the cortex construction of fur-bearing animal, through experiment sieving, the present invention has filtered out and can promote active component infiltration and the penetrating agent trisiloxane ethoxylate, trisiloxanes polyoxyethylene ether, fatty alcohol-polyoxyethylene ether and the sodium lauryl sulphate that have no side effect.Preferably, in further screening test, find when penetrating agent selects non-ionic surface active material to be combined with special ratios with anionic surface active substances, in the situation that guaranteeing animal to have no side effect, can further significantly promote active component to the infiltration of animal cortex, therefore determine that it is the preferred embodiment of the present invention.
Another aspect of the present invention relates to the preparation method of aforementioned pharmaceutical compositions, prepared by the technique of the various routines that it can be known by these those skilled in the art, and these processing steps are that those skilled in the art can know.
For example, when pharmaceutical composition of the present invention is prepared into spray, preferably, by mixing such as described active ingredient combination, surfactant, solvents, stir, make all active substance uniform dissolution or be scattered in solvent, obtain spray.Wherein said solvent can be ethanol, propanol, n-butyl alcohol, acetone, water etc.
When pharmaceutical composition of the present invention is prepared into ointment, preferably by following steps, prepare:
1) active ingredient combination of formula ratio is mixed with the penetrating agent of formula ratio, and stir, can add appropriate solvent if desired;
2) get the substrate of formula ratio, be heated to 90-120 ℃, make its fusing;
3) get the substrate of the fusing that accounts for formula ratio approximately 1/2 weight, the mixture that adds wherein step 1 to obtain while stirring, until stir;
4) in the mixture obtaining to step 3 while stirring, add residue substrate, until stir, cooling, obtain ointment of the present invention.
Drug conjugates described in another aspect of the present invention relates to or described pharmaceutical composition are for the preparation of the purposes in the medicine of control fur-bearing animal body demodicid mite.Preferably, described fur-bearing animal is cattle, sheep, rabbit.During use, affected part can be smeared or be sprayed on to described conjugate or compositions, smear consumption or spray consumption and can be easy to determine according to the order of severity of body demodicid mite.
The present invention's various raw materials used are as commercially available in active component and auxiliary agent and substrate etc. are, can be purchased from Tianjin Min Bo biochemistry Science and Technology Ltd., western Shandong veterinary drug limited company, Ren Bang bio tech ltd, Xi'an etc. such as described emaricin, flumethrin and Amitraz etc.; Described Chinese crude drug can be purchased from Baoding good English medical material distribution centre, the capable Chinese crude drug of Anguo City Luo Shen company, Shandong Ya Kang Pharmaceutical limited company etc.Described penetrating agent and substrate can be purchased from Shangyu Zhe Chuan Chemical Co., Ltd., Zhejiang Xinan Chemical Industry Group Co.Ltd, Weifang Hao Yuan industry auxiliary agent company limiteies etc.The present invention's other raw materials used are also on market, to be easy to access.
Beneficial effect of the present invention is mainly manifested in following several respects:
1) in active ingredient combination of the present invention, the active component of different mechanism of action, different control spectrums is mixed to application, can prevent or delay the resistance development of body demodicid mite to medicine on the one hand, on the other hand, because each composition mechanism of action is not quite similar, after combination, the prevention effect of body demodicid mite is better than to each single dose, Synergistic.
2) in above-mentioned formula, add Chinese medicine ingredients, can further prevent or delay on the one hand body demodicid mite resistance and produce; On the other hand, active ingredient of Chinese herbs can form the complementation of action effect with Western medicine chemical composition, reduce the use of Western medicine chemical composition, extends the medicament lasting period etc.
3) in compositions of the present invention, adding of penetrating agent can help active component to infiltrate effectively and rapidly cortex, and this contributes to the performance of drug effect, effectively prevents and treats body demodicid mite.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these specific embodiment.One skilled in the art would recognize that the present invention contained all alternatives, improvement project and the equivalents that within the scope of claims, may comprise.
Embodiment 1
Take Radix Sophorae Flavescentis 90g, Realgar 150g, Fructus Cnidii 210g, Herba Plantaginis 90g, Radix Glycyrrhizae 120g, Herba Andrographis 90g, Radix Angelicae Dahuricae 210g, Fructus Kochiae 150g, by its mixing pulverizing, then use 65% alcohol dipping 45 hours, during jolting or stir 3 times; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 3 times again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be Chinese medicine extract, about 180g.
Take above-mentioned Chinese medicine extract 150g, emaricin 150g, flumethrin 100g, Amitraz 80g, trisiloxanes polyoxyethylene ether 120g and sodium lauryl sulphate 120g, mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1440g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment of the present invention.
Embodiment 2
Take Radix Sophorae Flavescentis 90g, Realgar 150g, Fructus Cnidii 210g, Herba Plantaginis 90g, Radix Glycyrrhizae 120g, Herba Andrographis 90g, Radix Angelicae Dahuricae 210g, Fructus Kochiae 150g, by its mixing pulverizing, then use 65% alcohol dipping 45 hours, during jolting or stir 3 times; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 3 times again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be Chinese medicine extract, about 180g.
Take above-mentioned Chinese medicine extract 150g, emaricin 150g, flumethrin 100g, Amitraz 80g, fatty alcohol-polyoxyethylene ether 240g, mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1440g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment of the present invention.
Embodiment 3
Take Radix Sophorae Flavescentis 60g, Realgar 240g, Fructus Cnidii 150g, Herba Plantaginis 150g, Radix Glycyrrhizae 160g, Herba Andrographis 120g, Radix Angelicae Dahuricae 270g, Fructus Kochiae 210g, by its mixing pulverizing, then use 60% alcohol dipping 50 hours, during jolting or stir 2 times; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 3 times again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be Chinese medicine extract, about 200g.
Take above-mentioned Chinese medicine extract 120g, emaricin 100g, flumethrin 150g, Amitraz 100g, trisiloxane ethoxylate 360g, mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1600g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment of the present invention.
Embodiment 4
Take Radix Sophorae Flavescentis 60g, Realgar 240g, Fructus Cnidii 150g, Herba Plantaginis 150g, Radix Glycyrrhizae 160g, Herba Andrographis 120g, Radix Angelicae Dahuricae 270g, Fructus Kochiae 210g, by its mixing pulverizing, then use 60% alcohol dipping 50 hours, during jolting or stir 2 times; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 3 times again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be Chinese medicine extract, about 200g.
Take above-mentioned Chinese medicine extract 180g, emaricin 120g, flumethrin 120g, Amitraz 80g, trisiloxane ethoxylate 100g, fatty alcohol-polyoxyethylene ether 150g, mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 2200g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment of the present invention.
Embodiment 5
Take emaricin 150g, flumethrin 100g, Amitraz 80g, fatty alcohol-polyoxyethylene ether 120g and sodium lauryl sulphate 120g, mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1350g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment of the present invention.
Comparative example 1
Take emaricin 350g, azone 180g, the two is mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1400g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment.
Comparative example 2
Take flumethrin 300g, azone 150g, the two is mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1300g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment.
Comparative example 3
Take Amitraz 300g, azone 150g, the two is mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 1300g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment.
Comparative example 4
Take Radix Sophorae Flavescentis 90g, Realgar 150g, Fructus Cnidii 210g, Herba Plantaginis 90g, Radix Glycyrrhizae 120g, Herba Andrographis 90g, Radix Angelicae Dahuricae 210g, Fructus Kochiae 150g, by its mixing pulverizing, then use 65% alcohol dipping 45 hours, during jolting or stir 3 times; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 3 times again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be Chinese medicine extract, about 180g.
Take above-mentioned Chinese medicine extract 160g, azone 75g, the two is mixed, and stir, obtain the mixture A of active component and penetrating agent;
Take 750g glycerol, be heated to 110 ℃, make its fusing; Then be divided into two parts, in portion, added while stirring wherein mixture A obtained above, until stir; After stirring, continue to add wherein another part of glycerol, stir, be cooled to room temperature, obtain ointment.
Clinical effect trial
1, experimental animal:
The rabbit of natural infection acarid, the about 1.5-2kg of body weight, Tianjin feed lot provides;
2, test grouping and administration:
By 500 of the rabbits of natural infection acarid, be divided at random totally 10 groups of A-J, 50 every group, respectively above-described embodiment and the prepared medicine of comparative example are applied in to affected part, guarantee that between each group, dosage is consistent.For each group, every other day smear once, smear altogether three times.
Table 1 is respectively organized dosage regimen
| Group # | Dosage regimen |
| A | Embodiment 1 medicine |
| B | Embodiment 2 medicines |
| C | Embodiment 3 medicines |
| D | Embodiment 4 medicines |
| E | Embodiment 5 medicines |
| F | Comparative example 1 medicine |
| G | Comparative example 2 medicines |
| H | Comparative example 3 medicines |
| I | Comparative example 4 medicines |
| J | Contrast (not administration) |
3, curative effect determinate standard
Cure: animal body acaricide shape all disappears;
Take a turn for the better: animal body acaricide shape partly disappears;
Invalid: animal body acaricide shape is without significant change;
4, result investigation
Administration is after ten days the last time, and the condition of illness of rabbit is respectively organized in investigation, and after 30 days its recurrence of follow up survey.The results are shown in following table 2.Wherein, condition of illness recurrence investigation is for observing the rabbit of having cured recurrence at the appointed time, and investigation statistics.
Wherein:
Table 2 is respectively organized result investigation and is gathered
| Group # | Take a turn for the better (only) | Cure (only) | Invalid (only) | Cure rate | Total effective rate | Recurrence (only) | Relapse rate |
| A | 0 | 50 | 0 | 100.0％ | 100.0％ | 0 | 0.0％ |
| B | 2 | 48 | 0 | 96.0％ | 100.0％ | 0 | 0.0％ |
| C | 4 | 46 | 0 | 92.0％ | 100.0％ | 0 | 0.0％ |
| D | 2 | 48 | 0 | 96.0％ | 100.0％ | 0 | 0.0％ |
| E | 4 | 46 | 0 | 92.0％ | 100.0％ | 3 | 6.5％ |
| F | 6 | 37 | 7 | 74.0％ | 86.0％ | 5 | 13.5％ |
| G | 7 | 35 | 8 | 70.0％ | 84.0％ | 7 | 20.0％ |
| H | 5 | 38 | 7 | 76.0％ | 86.0％ | 7 | 18.4％ |
| I | 9 | 31 | 10 | 62.0％ | 80.0％ | 4 | 12.9％ |
| J | 0 | 0 | 50 | --- | --- | --- | --- |
By the above results, be not difficult to find out, each group (A-E) of administration medicine of the present invention, no matter cure rate or total effective rate are all greater than contrast medicament (group F-I).The cure rate of the group A of for example administration embodiment of the present invention 1 medicine is 100%, and total effective rate is 100%; The cure rate of the group B of the administration embodiment of the present invention 2 medicines is 96%, and total effective rate is 100%.And the cure rate of the group F of administration comparative example 1 medicine is only 74%, total effective rate is only 86%; The cure rate of the group G of administration comparative example example 2 medicines is only 70%, and total effective rate is only 84%.This explanation, in the present invention, when by the selected emaricin of the present invention, flumethrin, Amitraz and described Chinese medicine extract administering drug combinations, with respect to individually dosed separately processing, cure rate and total effective rate all significantly increase, and between selected each component of the present invention, have produced synergism.
Further, in the present invention, when selecting suitable penetrating agent and suitable compatibility thereof, can further increase curative effect as cure rate.Concrete, for example, in the embodiment of the present invention 1, penetrating agent is selected trisiloxanes polyoxyethylene ether and the sodium lauryl sulphate of the ratio of 1:1, in follow-up investigation, finds, the cure rate of the group A of this embodiment of administration is higher than other groups (B-E) of administration other drug of the present invention.That is to say, specific penetrating agent compatibility (for example ratio of trisiloxanes polyoxyethylene ether and sodium lauryl sulphate 1:1) can further increase the curative effect of medicine of the present invention.
Further, in medicine of the present invention, the Chinese medicine and western medicine drug combination mode that has adopted Western medicine chemical composition to mix with Chinese medicine ingredients, this can reduce the recurrence of animal body acaricide shape greatly.The relapse rate of the group A-D of for example administration embodiment of the present invention 1-4 is 0, and the relapse rate of the group F-I of administration comparative example 1-4 is all greater than 10%, and the relapse rate of especially organizing G, H group is particularly high, reaches 20% left and right.In addition, group A-D is more directly perceived with the Data Comparison of group E, is all pharmaceutical preparation of the present invention, and when as preferred implementation, while containing Chinese medicine ingredients in preparation, condition of illness does not recur substantially; And while not containing Chinese medicine ingredients in preparation, after 30 days, have the situation of recurrence; Visible, add after Chinese medicine ingredients, in the situation that guaranteeing cure rate, extended drug effect, further avoided disease relapse.
Above-mentioned example is only to further explanation of the present invention; it is not limitation of the invention; by the scheme that such scheme is simply adjusted and then obtained; same within the application's protection domain; that is to say, within not departing from all similar replacement of spirit of the present invention and changing and to be all deemed to be included in scope of the present invention.
Claims (10)
1. prevent and treat a drug conjugates for fur-bearing animal body demodicid mite, it comprises following component and weight portion thereof:
Emaricin 10-20 part
Flumethrin 5-15 part
Amitraz 5-10 part.
2. conjugate according to claim 1, is characterized in that, described conjugate also comprises Chinese medicine extract, and wherein each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
Radix Sophorae Flavescentis 1-5 part, Realgar 2-8 part, Fructus Cnidii 5-8 part, Herba Plantaginis 2-5 part, Radix Glycyrrhizae 3-6 part, Herba Andrographis 2-4 part, Radix Angelicae Dahuricae 6-9 part, Fructus Kochiae 3-7 part.
3. conjugate according to claim 2, is characterized in that, each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
Radix Sophorae Flavescentis 2-4 part, Realgar 4-6 part, Fructus Cnidii 6-8 part, Herba Plantaginis 2-4 part, Radix Glycyrrhizae 4-5 part, Herba Andrographis 3-4 part, Radix Angelicae Dahuricae 7-8 part, Fructus Kochiae 4-6 part.
4. conjugate according to claim 3, is characterized in that, each component and weight portion thereof are:
Wherein, described Chinese medicine is comprised of the component of following weight portion:
3 parts of Radix Sophorae Flavescentiss, 5 parts of Realgars, 7 parts of Fructus Cnidiis, 3 parts of Herba Plantaginis, 4 parts, Radix Glycyrrhizae, 3 parts of Herba Andrographis, 7 parts of the Radixs Angelicae Dahuricae, 5 parts of the Fructus Kochiae.
5. according to the conjugate described in claim 3 or 4, it is characterized in that, the extracting method of described Chinese medicine extract is: the Chinese medicinal components of formula ratio is pulverized, is then used the alcohol dipping 30-50 hour of 55-70%, during jolting or stir 2-3 time; Filter afterwards, collect lixiviating solution, filtering residue is used to said method lixiviate 2-3 time again; Finally merge lixiviating solution, and by lixiviating solution concentrating under reduced pressure, obtain thick liquid, be described Chinese medicine extract.
6. a pharmaceutical composition of preventing and treating fur-bearing animal body demodicid mite, is characterized in that, it is active component that described pharmaceutical composition be take the arbitrary described conjugate of claim 1-5, and described pharmaceutical composition is prepared into spray or ointment.
7. compositions according to claim 6, is characterized in that, described medicine is ointment, and it comprises following component and weight portion thereof:
The arbitrary described drug conjugates 5-40 part of claim 1-5
Penetrating agent 2-30 part
Substrate 20-100 part;
Preferably, each component and weight portion thereof are:
The arbitrary described drug conjugates 10-30 part of claim 1-5
Penetrating agent 5-20 part
Substrate 40-80 part;
Wherein, described penetrating agent is selected from one or more in trisiloxane ethoxylate, trisiloxanes polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, sodium lauryl sulphate;
Described substrate is selected from glycerol, lanoline or liquid paraffin.
8. compositions according to claim 7, is characterized in that, each component and weight portion thereof are preferred:
20 parts of the arbitrary described drug conjugates of claim 1-5
10 parts of penetrating agent
60 parts of substrate
Wherein, described penetrating agent is selected from trisiloxanes polyoxyethylene ether and sodium lauryl sulphate, and the weight ratio of the two is 1:1;
Described substrate is selected from glycerol.
9. the conjugate described in claim 1-5 or the compositions described in claim 6-8 are for the preparation of the purposes in the medicine of control fur-bearing animal body demodicid mite.
10. purposes according to claim 9, is characterized in that, described fur-bearing animal is cattle, sheep, rabbit.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410179344.3A CN104027342A (en) | 2014-04-27 | 2014-04-27 | Medicinal composition for preventing and treating fur animal mites |
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| CN201410179344.3A CN104027342A (en) | 2014-04-27 | 2014-04-27 | Medicinal composition for preventing and treating fur animal mites |
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| CN201410179344.3A Pending CN104027342A (en) | 2014-04-27 | 2014-04-27 | Medicinal composition for preventing and treating fur animal mites |
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| CN102000141A (en) * | 2010-11-29 | 2011-04-06 | 齐晓东 | External traditional Chinese medicine for treating skin disease of livestock |
| CN102784350A (en) * | 2012-08-07 | 2012-11-21 | 孙雅儒 | Mite killing bactericide and preparation method of mite killing bactericide |
| CN103142908A (en) * | 2013-03-29 | 2013-06-12 | 武汉中博绿亚生物科技有限公司 | Spray for killing mites on body surface of pet and preparation method of spray |
| CN103467463A (en) * | 2013-09-18 | 2013-12-25 | 南开大学 | Lignin derivatives as well as preparation method and use thereof |
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| CN102000141A (en) * | 2010-11-29 | 2011-04-06 | 齐晓东 | External traditional Chinese medicine for treating skin disease of livestock |
| CN102784350A (en) * | 2012-08-07 | 2012-11-21 | 孙雅儒 | Mite killing bactericide and preparation method of mite killing bactericide |
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