CN102727700A - Traditional Chinese medicine granule for treating ascaris suum and preparation method thereof - Google Patents
Traditional Chinese medicine granule for treating ascaris suum and preparation method thereof Download PDFInfo
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- CN102727700A CN102727700A CN2012102496801A CN201210249680A CN102727700A CN 102727700 A CN102727700 A CN 102727700A CN 2012102496801 A CN2012102496801 A CN 2012102496801A CN 201210249680 A CN201210249680 A CN 201210249680A CN 102727700 A CN102727700 A CN 102727700A
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Abstract
The invention provides a traditional Chinese medicine granule for treating ascaris suum and a preparation method thereof. The traditional Chinese medicine granule comprises the following components in parts by weight: 15-20 parts of granatum, 2-5 parts of betel nut and 3-5 parts of quispualis indica which are prepared by decocting and adding with auxiliary materials. The traditional Chinese medicine granule provided by the invention is formulated reasonably to be an effective medicine for treating ascaris suum, thus having the advantages of rapid effect, real curative effect, no medicine residue and no any toxic and side effects, and being convenient to convey and rapid to use; and in addition, the preparation method is simple, so that the traditional Chinese medicine granule for treating ascaris sum is appropriate for meeting the demand of industrialized production in a large scale.
Description
Technical field
The present invention relates to a kind of Chinese medicine granules and preparation method thereof, especially a kind of sick Chinese medicine granules of ascaris suum and preparation method thereof of treating.
Background technology
The ascaris suum disease is that ascarid colonizes in the small intestinal of pig and causes that pig digestive disorders, body are become thin and a kind of nematicide of retarded growth; It also is the widest common endobiosis parasitosis of a kind of distribution; The piglet at main infringement 2-6 monthly age; Causing the dysplasia of disease pig, growth retardation, is the one of the main reasons that causes cad pig, can cause when serious that the disease pig is dead.Yet the treatment present stage for this disease does not still have effective method, therefore utilizes the Chinese material medicine resource of China's abundant, through Chinese medicine is rationally screened and prescription, research and develop a kind of newtype drug of treating the ascaris suum disease and has very important production practices meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of sick Chinese medicine granules of ascaris suum of treating.
Another technical problem to be solved by this invention is to provide the method for preparing of the sick Chinese medicine granules of above-mentioned treatment ascaris suum.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, by 15～20 parts of its parts by weight Pericarpium Granatis, 2～5 parts of Semen Arecaes, 3～5 parts of Fructus Quisqualis.
Preferably, the Chinese medicine granules that above-mentioned treatment ascaris suum is sick is by 16～18 parts of its parts by weight Pericarpium Granatis, 3～4 parts of Semen Arecaes, 4～5 parts of Fructus Quisqualis.
Preferably, the Chinese medicine granules that above-mentioned treatment ascaris suum is sick is by 17 parts of its parts by weight Pericarpium Granatis, 3 parts of Semen Arecaes, 4 parts of Fructus Quisqualis.
Preferably, the Chinese medicine granules that above-mentioned treatment ascaris suum is sick is obtained by following method:
(1) taking by weighing Pericarpium Granati, Semen Arecae, Fructus Quisqualis by weight is raw material, mix homogeneously;
(2) in above-mentioned three flavor Chinese medicines, add the water that medical material gross weight 10-20 doubly measures, decoct 2 times, decocted 1.5-2.0 hour for the first time, decocted 1.5-2.0 hour for the second time, collecting decoction, filtrating was left standstill 12-36 hour, filtered;
(3) gained is filtrated under 70-80 ℃ of condition, be concentrated into relative density 1.24-1.36, pulverize the oven dry back under the 60-70 ℃ of condition, obtains medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 80%-90% (v/v) ethanol and cross the 10-30 mesh sieve, under 60-70 ℃ of condition, dry,, promptly get after the 10-30 mesh sieve.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) takes by weighing 15～20 parts of Pericarpium Granatis, 2～5 parts of Semen Arecaes, Fructus Quisqualis by weight and be raw material, mix homogeneously for 3～5 parts;
(2) in above-mentioned three flavor Chinese medicines, add the water that medical material gross weight 10-20 doubly measures, decoct 2 times, decocted 1.5-2.0 hour for the first time, decocted 1.5-2.0 hour for the second time, collecting decoction, filtrating was left standstill 12-36 hour, filtered;
(3) gained is filtrated under 70-80 ℃ of condition, be concentrated into relative density 1.24-1.36, pulverize the oven dry back under the 60-70 ℃ of condition, obtains medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 80%-90% (v/v) ethanol and cross the 10-30 mesh sieve, under 60-70 ℃ of condition, dry,, promptly get after the 10-30 mesh sieve.
Preferably, the method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) takes by weighing 17 parts of Pericarpium Granatis, 3 parts of Semen Arecaes, Fructus Quisqualis by weight and be raw material, mix homogeneously for 4 parts;
(2) water of 10 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 2.0 hours for the first time, decocted 1.5 hours for the second time, and collecting decoction, filtrating was left standstill 24 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.28,65 ℃ of conditions of relative density under 80 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 85% (v/v) ethanol and cross 20 mesh sieves, under 65 ℃ of conditions, dry,, promptly get after 30 mesh sieves.
Preferably, the method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, the weight ratio of said step (4) medicinal powder and sucrose is 10:6-8.
Preferably, the method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, the weight ratio of said step (4) medicinal powder and sucrose is 10:7.
Above-mentioned relative density is meant the proportion of this filtrating.
The consumption of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick stirs and mixes drink for adding in the 10kg water by every 20g Chinese medicine granules, and fasting is 12～18 hours before the pig anthelmintic, and logotype 4-5 days is a course of treatment.
The invention has the beneficial effects as follows:
The Chinese medicine granules that above-mentioned treatment ascaris suum is sick; With the Chinese medicine reasonable formula, for pig industry provides a kind of ascaris suum sick effective medicine, have instant effect, curative effect really, no drug residue, characteristics without any side effects; And convenient transportation, easy to use; Its preparation method is simple, is fit to requirements of large-scale industrial production.
The specific embodiment
Below in conjunction with specific embodiment technical scheme according to the invention is further described.
Embodiment 1
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 17kg, Semen Arecae 3kg, Fructus Quisqualis 4kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 17kg, Semen Arecae 3kg, Fructus Quisqualis 4kg is raw material, mix homogeneously;
(2) water of 10 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 2.0 hours for the first time, decocted 1.5 hours for the second time, and collecting decoction, filtrating was left standstill 24 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.28,65 ℃ of conditions of relative density under 80 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:7, processes granule with 85% (v/v) ethanol and crosses 20 mesh sieves, under 65 ℃ of conditions, dries, and after 30 mesh sieves, promptly gets.
Embodiment 2
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 15kg, Semen Arecae 5kg, Fructus Quisqualis 3kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 15kg, Semen Arecae 5kg, Fructus Quisqualis 3kg is raw material, mix homogeneously;
(2) water of 20 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 2.0 hours for the first time, decocted 1.5 hours for the second time, and collecting decoction, filtrating was left standstill 36 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.36,60 ℃ of conditions of relative density under 80 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:8, processes granule with 90% (v/v) ethanol and crosses 30 mesh sieves, under 60 ℃ of conditions, dries, and after 10 mesh sieves, promptly gets.
Embodiment 3
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 20kg, Semen Arecae 2kg, Fructus Quisqualis 5kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 20kg, Semen Arecae 2kg, Fructus Quisqualis 5kg is raw material, mix homogeneously;
(2) water of 10 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 1.5 hours for the first time, decocted 2.0 hours for the second time, and collecting decoction, filtrating was left standstill 12 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.24,70 ℃ of conditions of relative density under 70 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:6, processes granule with 80% (v/v) ethanol and crosses 10 mesh sieves, under 70 ℃ of conditions, dries, and after 30 mesh sieves, promptly gets.
Embodiment 4
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 16kg, Semen Arecae 4kg, Fructus Quisqualis 4kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 16kg, Semen Arecae 4kg, Fructus Quisqualis 4kg is raw material, mix homogeneously;
(2) water of 15 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 1.7 hours for the first time, decocted 1.7 hours for the second time, and collecting decoction, filtrating was left standstill 20 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.30,65 ℃ of conditions of relative density under 75 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:6.5, processes granule with 85% (v/v) ethanol and crosses 20 mesh sieves, under 65 ℃ of conditions, dries, and after 20 mesh sieves, promptly gets.
Embodiment 5
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 18kg, Semen Arecae 3kg, Fructus Quisqualis 5kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 18kg, Semen Arecae 3kg, Fructus Quisqualis 5kg is raw material, mix homogeneously;
(2) water of 13 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 1.8 hours for the first time, decocted 1.6 hours for the second time, and collecting decoction, filtrating was left standstill 28 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.26,63 ℃ of conditions of relative density under 72 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:7.8, processes granule with 85% (v/v) ethanol and crosses 20 mesh sieves, under 63 ℃ of conditions, dries, and after 30 mesh sieves, promptly gets.
Embodiment 6
A kind of sick Chinese medicine granules of ascaris suum of treating is made up of Pericarpium Granati, Semen Arecae and Fructus Quisqualis, wherein Pericarpium Granati 19kg, Semen Arecae 3kg, Fructus Quisqualis 4kg.
The method for preparing of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick, concrete preparation process is following:
(1) taking by weighing Pericarpium Granati 19kg, Semen Arecae 3kg, Fructus Quisqualis 4kg is raw material, mix homogeneously;
(2) water of 16 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 1.7 hours for the first time, decocted 1.5 hours for the second time, and collecting decoction, filtrating was left standstill 15 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.32,65 ℃ of conditions of relative density under 80 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, the weight ratio of wherein said medicinal powder and sucrose is 10:7, processes granule with 85% (v/v) ethanol and crosses 30 mesh sieves, under 70 ℃ of conditions, dries, and after 30 mesh sieves, promptly gets.
The said Chinese crude drug of one of embodiment 1-6 is the commercially available prod, and each amounts of components is increased or reduces according to same ratio, and the parts by weight relation of each component of gained all belongs to protection scope of the present invention.
The said Chinese crude drug of embodiment 1-6 all meets " Chinese veterinary drug allusion quotation " version two ministerial standards in 2010.
The composition principle of Chinese medicine oral liquid according to the invention is: Pericarpium Granati has insecticidal action, astringing to arrest bleeding in the side; Semen Arecae is killed effect to Enterozoa, and to drive away polypide with discharge function be its advantage; The existing good effect of killing ascarid of Fructus Quisqualis, the sliding slowly sharp property of leading to intestinal of tool again; All medicines share, and Synergistic is remarkably productive to treatment ascaris suum disease each other, especially adopts embodiment 1 said proportioning, and the effect of driving away polypide under rushing down is very remarkable, particularly is fit to the sick treatment of ascaris suum.
The clinical trial example:
The consumption of the Chinese medicine granules that above-mentioned treatment ascaris suum is sick stirs and mixes drink for adding in the 10kg water by every 20g Chinese medicine granules, and fasting is 16 hours before the pig anthelmintic, and logotype 4 days was a course of treatment.
In November, 2010,50 piglets morbidities that Heze, Shandong self-employed pig raiser raises, clinical symptoms: breathe, fervescence, weight loss and lethargy, dead pig occurs.Analyse visible hemorrhage, the pneumonia of pig liver, form nebulous milk spots in liver surface; Gather feces and detect the discovery worm's ovum, be diagnosed as the ascaris suum disease.Then treat with embodiment 1 said Chinese medicine granules, medication is after 4 days, and the state of an illness is controlled, does not occur diarrhoea, lassitude phenomenon again.
Above-mentioned detailed description of this a kind of Chinese medicine granules of treating the ascaris suum disease and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (8)
1. treat the sick Chinese medicine granules of ascaris suum for one kind, it is characterized in that: form by Pericarpium Granati, Semen Arecae and Fructus Quisqualis, by 15～20 parts of its parts by weight Pericarpium Granatis, 2～5 parts of Semen Arecaes, 3～5 parts of Fructus Quisqualis.
2. the sick Chinese medicine granules of treatment ascaris suum according to claim 1 is characterized in that: by 16～18 parts of its parts by weight Pericarpium Granatis, 3～4 parts of Semen Arecaes, 4～5 parts of Fructus Quisqualis.
3. the sick Chinese medicine granules of treatment ascaris suum according to claim 2 is characterized in that: by 17 parts of its parts by weight Pericarpium Granatis, 3 parts of Semen Arecaes, 4 parts of Fructus Quisqualis.
4. according to the sick Chinese medicine granules of the described treatment of one of claim 1-3 ascaris suum, it is characterized in that: obtain by following method:
(1) taking by weighing Pericarpium Granati, Semen Arecae, Fructus Quisqualis by weight is raw material, mix homogeneously;
(2) in above-mentioned three flavor Chinese medicines, add the water that medical material gross weight 10-20 doubly measures, decoct 2 times, decocted 1.5-2.0 hour for the first time, decocted 1.5-2.0 hour for the second time, collecting decoction, filtrating was left standstill 12-36 hour, filtered;
(3) gained is filtrated under 70-80 ℃ of condition, be concentrated into relative density 1.24-1.36, pulverize the oven dry back under the 60-70 ℃ of condition, obtains medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 80%-90% (v/v) ethanol and cross the 10-30 mesh sieve, under 60-70 ℃ of condition, dry,, promptly get after the 10-30 mesh sieve.
5. the method for preparing of the sick Chinese medicine granules of the described treatment of claim 1 ascaris suum, it is characterized in that: concrete preparation process is following:
(1) takes by weighing 15～20 parts of Pericarpium Granatis, 2～5 parts of Semen Arecaes, Fructus Quisqualis by weight and be raw material, mix homogeneously for 3～5 parts;
(2) in above-mentioned three flavor Chinese medicines, add the water that medical material gross weight 10-20 doubly measures, decoct 2 times, decocted 1.5-2.0 hour for the first time, decocted 1.5-2.0 hour for the second time, collecting decoction, filtrating was left standstill 12-36 hour, filtered;
(3) gained is filtrated under 70-80 ℃ of condition, be concentrated into relative density 1.24-1.36, pulverize the oven dry back under the 60-70 ℃ of condition, obtains medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 80%-90% (v/v) ethanol and cross the 10-30 mesh sieve, under 60-70 ℃ of condition, dry,, promptly get after the 10-30 mesh sieve.
6. the method for preparing of the Chinese medicine granules that treatment ascaris suum according to claim 5 is sick is characterized in that: concrete preparation process is following:
(1) takes by weighing 17 parts of Pericarpium Granatis, 3 parts of Semen Arecaes, Fructus Quisqualis by weight and be raw material, mix homogeneously for 4 parts;
(2) water of 10 times of amounts of adding medical material gross weight in above-mentioned three flavor Chinese medicines decocts 2 times, decocts 2.0 hours for the first time, decocted 1.5 hours for the second time, and collecting decoction, filtrating was left standstill 24 hours, filtered;
(3) gained is filtrated in being concentrated into oven dry back pulverizing under 1.28,65 ℃ of conditions of relative density under 80 ℃ of conditions, obtain medicinal powder;
(4) in medicinal powder, add the sucrose mixing, process granule with 85% (v/v) ethanol and cross 20 mesh sieves, under 65 ℃ of conditions, dry,, promptly get after 30 mesh sieves.
7. according to claim 5 or 6 described method for preparinies of treating the sick Chinese medicine granules of ascaris suums, it is characterized in that: the weight ratio of said step (4) medicinal powder and sucrose is 10:6-8.
8. the method for preparing of the Chinese medicine granules that treatment ascaris suum according to claim 7 is sick, it is characterized in that: the weight ratio of said step (4) medicinal powder and sucrose is 10:7.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973755A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Composition for treating ascariasis and teniasis in livestock and poultry, and preparation method thereof |
| CN104383392A (en) * | 2014-11-04 | 2015-03-04 | 重庆泰通动物药业有限公司 | Traditional Chinese veterinary medicine for preventing and treating poultry gastrointestinal parasite |
| CN105056159A (en) * | 2015-09-25 | 2015-11-18 | 山东新希望六和集团有限公司 | Medicine for treating parasitic diseases of pigs and preparation method thereof |
-
2012
- 2012-07-18 CN CN2012102496801A patent/CN102727700A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973755A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Composition for treating ascariasis and teniasis in livestock and poultry, and preparation method thereof |
| CN102973755B (en) * | 2012-11-22 | 2015-04-22 | 青岛绿曼生物工程有限公司 | Composition for treating ascariasis and teniasis in livestock and poultry, and preparation method thereof |
| CN104383392A (en) * | 2014-11-04 | 2015-03-04 | 重庆泰通动物药业有限公司 | Traditional Chinese veterinary medicine for preventing and treating poultry gastrointestinal parasite |
| CN105056159A (en) * | 2015-09-25 | 2015-11-18 | 山东新希望六和集团有限公司 | Medicine for treating parasitic diseases of pigs and preparation method thereof |
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Application publication date: 20121017 |