CN105362936A - Composition capable of assisting blood lipid reducing and preparation method of composition - Google Patents
Composition capable of assisting blood lipid reducing and preparation method of composition Download PDFInfo
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- CN105362936A CN105362936A CN201510829639.5A CN201510829639A CN105362936A CN 105362936 A CN105362936 A CN 105362936A CN 201510829639 A CN201510829639 A CN 201510829639A CN 105362936 A CN105362936 A CN 105362936A
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- rhizoma curcumae
- curcumae longae
- fructus crataegi
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Abstract
The invention provides a composition capable of assisting blood lipid reducing and a preparation method of the composition. The composition is prepared by mixing, by weight, 25-78 parts of red yeast rice powder, 5-70 parts of hawthorn fruit powder and 1-10 parts of radix curcuma extract. The composition capable of assisting blood lipid reducing has the advantages that the constituents of the composition are combined to achieve synergic effects of promoting blood circulation to remove blood stasis and enriching and nourishing blood, the composition capable of assisting blood lipid reducing is especially suitable for being taken by people with blood stasis and blood-yin deficiency type high blood lipid and low in dose, and the preparation method of the composition is simple, convenient to use and capable of satisfying the requirements of large-scale industrial production.
Description
Technical field
The present invention relates to a kind of composition and method of making the same, especially a kind of composition and method of making the same with auxiliary lipid-lowering efficacy.
Background technology
Hyperlipemia is the key factor causing atherosclerosis and coronary heart disease.At drug treatment, Chinese medicine has the little unique advantage of toxic and side effects in adjusting blood lipid.
But due to Chinese medicine ingredients comparatively complicated, the effective blood fat reducing monomer of Chinese medicine containing one or more adjusting blood lipid itself, application present stage Chinese medicine effective monomer compatibility theory, makes to carry out specific cooperation between Chinese medicinal components to promote the fat-reducing effect between medicine, has very important using value.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions with auxiliary lipid-lowering efficacy.
Another technical problem to be solved by this invention is to provide the above-mentioned preparation method with the compositions of auxiliary lipid-lowering efficacy.
For solving the problems of the technologies described above, technical scheme of the present invention is:
There is a compositions for auxiliary lipid-lowering efficacy, be made up of Hongqu powder (red colouring agent), Fructus Crataegi powder and Rhizoma Curcumae Longae extract, by its weight parts Hongqu powder (red colouring agent) 25-78 part, Fructus Crataegi powder 5-70 part, Rhizoma Curcumae Longae extract 1-10 part.
Preferably, the above-mentioned compositions with auxiliary lipid-lowering efficacy, by its weight parts Hongqu powder (red colouring agent) 45-60 part, Fructus Crataegi powder 25-45 part, Rhizoma Curcumae Longae extract 2-8 part.
Preferably, the above-mentioned compositions with auxiliary lipid-lowering efficacy, by its weight parts Hongqu powder (red colouring agent) 54 parts, Fructus Crataegi powder 37 parts, Rhizoma Curcumae Longae extract 7 parts.
Preferably, the above-mentioned compositions with auxiliary lipid-lowering efficacy, described Rhizoma Curcumae Longae extract is obtained by alcohol extraction process.
The above-mentioned preparation method with the compositions of auxiliary lipid-lowering efficacy, concrete steps are as follows:
(1) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are crossed 20-60 mesh sieve respectively, and take Hongqu powder (red colouring agent) by prescription amount proportioning, Fructus Crataegi powder, Rhizoma Curcumae Longae extract be raw material;
(2) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are put into blending tank and be mixed to evenly, again cross 20-60 mesh sieve;
(3), after mixing, material is standby to be deposited, inspection, fill.
The above-mentioned usage and dosage with the compositions of auxiliary lipid-lowering efficacy: every day 0.5 gram.
The invention has the beneficial effects as follows:
The above-mentioned compositions with auxiliary lipid-lowering efficacy, each component synergism, can blood circulation promoting and blood stasis dispelling, and blood-supplementing blood-nourishing, has effect of auxiliary antilipemic, and be particularly applicable to stagnation of blood stasis, hyperlipemia crowd that insufficiency of blood the moon loses pattern of syndrome takes, dose is few; Its preparation method is simple, easy to use, is applicable to the needs that large-scale industrial is produced.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
A kind of compositions with auxiliary lipid-lowering efficacy, be made up of Hongqu powder (red colouring agent), Fructus Crataegi powder and Rhizoma Curcumae Longae extract, concrete consumption is in table 1 (each component is commercially available prod, and Rhizoma Curcumae Longae extract is the extract that alcohol extraction process obtains), and described compositions is obtained by following method:
(1) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are crossed 40 mesh sieves respectively, and take Hongqu powder (red colouring agent) by proportioning described in Table A, Fructus Crataegi powder, Rhizoma Curcumae Longae extract be raw material;
(2) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are put into blending tank mixing 50 minutes, until evenly, again cross 40 mesh sieves;
(3), after mixing, material is standby to be deposited, inspection, fill.
Table A
| Embodiment | Hongqu powder (red colouring agent) (kg) | Fructus Crataegi powder (kg) | Rhizoma Curcumae Longae extract (kg) |
| 1-1 | 78 | 11 | 10 |
| 1-2 | 75 | 9 | 1 |
| 1-3 | 60 | 25 | 7 |
| 1-4 | 64 | 19 | 9 |
| 1-5 | 56 | 35 | 8 |
| 1-6 | 54 | 37 | 7 |
| 1-7 | 50 | 43 | 6 |
| 1-8 | 30 | 5 | 5 |
| 1-9 | 39 | 56 | 3 |
| 1-10 | 35 | 60 | 4 |
| 1-11 | 45 | 45 | 3 |
| 1-12 | 25 | 70 | 2 |
The composition principle of compositions of the present invention is: in side, Hongqu powder (red colouring agent) has the effect of blood fat reducing, and the contained Kelin K that do not draw can stop generation cholesterol; Containing various active composition in Fructus Crataegi, as flavone compound, organic acid, dietary fiber and sterin etc.Fructus Crataegi is the one that in the health product of current adjusting blood lipid, frequency of utilization is the highest, and the pharmacological research of flavone compound also shows effect for reducing blood fat.Rhizoma Curcumae Longae extract has effect of blood circulation promoting and blood stasis dispelling.The mutual Synergistic of each component, reduces cholesterol, triglyceride is remarkably productive, improve hyperlipidemia Be very effective.
Embodiment 2
1 experiment purpose
Compositions auxiliary lipid-lowering efficacy of the present invention is evaluated.
2 experimental basis
" health food inspection and assessment technical specification " (version in 2003) method of promulgating according to health ministry is carried out.
3 materials, animal and other
3.1 laboratory samples:
There is described in embodiment 1-6 the compositions of auxiliary lipid-lowering efficacy.
3.2 laboratory animals and feedstuff:
SPF level SD rat 60, male, body weight 160 ± 20g, often organizes 12, is provided, the quality certification number: 11400700054422 by Beijing Vital River Experimental Animals Technology Co., Ltd..
High lipid food: 78.8% normal feedstuff, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica, 0.2% cholate.
3.3 laboratory animal environment:
SPF level barrier environment, the quality certification number: SYXK (Tianjin) 2012-0004.
3.4 main apparatus and consumables associated therewiths
Gastric perfusion needle, syringe, balance, spectrophotometer, refrigerated centrifuger, dissecting instrument, spectrophotometer, cholesterol, sodium cholate, serum total cholesterol (TC), triglyceride (TG), HDL-C (HDL) measure test kit.
4 experimental techniques
4.1 grouping
Three dosage groups (establishing basic, normal, high dosage group with 5 times, 10 times and 30 times of human body recommended dose (every day 0.5 gram) respectively), a blank group and a model group are established in experiment.5 groups altogether, often organize 12, gavage volume.It is 30 days that given the test agent gives the cycle.
4.2 hyperlipoidemias-prevention type is to given the test agent
Under experimental situation, feed normal feedstuff to rat, observe 5-10d, then get tail blood.Measure serum total cholesterol (TC) level.According to T-CHOL (TC) level, carry out random packet, the given the test agent of various dose is given while giving high lipid food, regularly weigh in, terminate fasting 16h in experiment, survey serum TC, triglyceride (TG) and high density lipoprotein (HDL) level.
5 date processing and result judge
Experiment SPSS16.0 carries out statistical analysis.
6 interpretations of result
6.1 modeling
Table 1 modeling is on the impact of TC
As shown in Table 1: initial TC and blank group TC there was no significant difference (P>0.05); Model group has significance to increase (P<0.05) with blank group and initial TC after 30 days giving high lipid food.Therefore, high blood lipid model success is made.
6.2 impacts on hyperlipemia rat body weight
On the impact that rat body weight increases after table 2 administration
As shown in Table 2, before modeling, each group rat body weight does not have significant difference (P>0.05), therefore, can show the front point reasonable set of modeling.After modeling, last body weight, each group rat body weight does not have significant difference (P>0.05), therefore, show that the body weight of said composition on laboratory animal does not affect.
The preventive effect of 6.3 couples of hyperlipemia rats TC, HDL and TG
Table 3 is on the impact of TG, HDL and TC
Note: have same letter not have significant difference, does not have same letter to have significant difference
As shown in Table 3:
TC:1) blank group numerical value is lower than model group, has significant difference (P<0.05) compared with model group; 2) administration group numerical value, higher than blank group, has significant difference (P<0.05) compared with blank group; 3) administration group (basic, normal, high dosage group) all has significant difference (P<0.05) compared with model group.
TG:1) blank group numerical value is lower than model group, has significant difference (P<0.05) compared with model group; 2) administration group numerical value is substantially higher than blank group, low, middle dosage is there was no significant difference (P>0.05) compared with blank group, and high dose group has significant difference (P<0.05) compared with blank group; 3) administration group (basic, normal, high dosage group) numerical value lower than model group, and has significant difference (P<0.05) compared with model group.
HDL:1) blank group numerical value is lower than model group, has significant difference (P<0.05) compared with model group; 2) administration group numerical value, higher than blank group, has significant difference (P<0.05) compared with blank group; 3) administration group (basic, normal, high dosage group) does not have significant difference (P>0.05) compared with model group.
According to " health food inspection and assessment technical specification " (version in 2003) judgment criteria, in TC, TG and HDL tri-indexs, TC, TG result is positive, then can judge that said composition has effect of auxiliary antilipemic.Under this experimental condition, TC is basic, normal, high, and three dosage experiments results are positive, and TG is basic, normal, high, and three dosage experiments results are positive, then can judge that said composition has effect of auxiliary antilipemic.
Conclusion: experiment shows, under this experiment condition, utilize the Arteriosclerosis rat model that high lipid food modeling is formed, in this embodiment, resulting composition has the effect of auxiliary antilipemic.In three dosage, the action effect of middle dosage group best (being converted to people, the day 2 times of dose for compositions referrer).
Above-mentioned detailed description of this kind of composition and method of making the same with auxiliary lipid-lowering efficacy being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (5)
1. there is a compositions for auxiliary lipid-lowering efficacy, it is characterized in that: be made up of Hongqu powder (red colouring agent), Fructus Crataegi powder and Rhizoma Curcumae Longae extract, by its weight parts Hongqu powder (red colouring agent) 25-78 part, Fructus Crataegi powder 5-70 part, Rhizoma Curcumae Longae extract 1-10 part.
2. the compositions with auxiliary lipid-lowering efficacy according to claim 1, is characterized in that: by its weight parts Hongqu powder (red colouring agent) 45-60 part, Fructus Crataegi powder 25-45 part, Rhizoma Curcumae Longae extract 2-8 part.
3. the compositions with auxiliary lipid-lowering efficacy according to claim 1, is characterized in that: by its weight parts Hongqu powder (red colouring agent) 54 parts, Fructus Crataegi powder 37 parts, Rhizoma Curcumae Longae extract 7 parts.
4. according to the compositions with auxiliary lipid-lowering efficacy one of claim 1-3 Suo Shu, it is characterized in that: described Rhizoma Curcumae Longae extract is obtained by alcohol extraction process.
5. there is described in claim 1 preparation method of the compositions of auxiliary lipid-lowering efficacy, it is characterized in that: concrete steps are as follows:
(1) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are crossed 20-60 mesh sieve respectively, and take Hongqu powder (red colouring agent) by prescription amount proportioning, Fructus Crataegi powder, Rhizoma Curcumae Longae extract be raw material;
(2) Hongqu powder (red colouring agent), Fructus Crataegi powder, Rhizoma Curcumae Longae extract are put into blending tank and be mixed to evenly, again cross 20-60 mesh sieve;
(3), after mixing, material is standby to be deposited, inspection, fill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105876776A (en) * | 2016-03-24 | 2016-08-24 | 大兴安岭百盛蓝莓科技开发有限公司 | Black fungus, blueberry and red yeast rice ultrafine instant nutritious meal replacement powder and preparation method thereof |
| CN106890307A (en) * | 2017-03-21 | 2017-06-27 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
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| CN1762441A (en) * | 2004-10-22 | 2006-04-26 | 山西亚宝药业集团股份有限公司 | Chinese medicine composition for treating hyperlipemia and preparing method thereof |
| CN102895268A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Lipid-lowering composition |
| CN103372073A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Red rice and hawthorn medicinal composition for regulating blood fat and preparation method of composition |
| CN104225466A (en) * | 2014-09-04 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicinal composition used for lowering blood lipid |
| CN104940295A (en) * | 2015-06-24 | 2015-09-30 | 天津天狮生物发展有限公司 | Blood fat reducing composition |
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2015
- 2015-11-25 CN CN201510829639.5A patent/CN105362936A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1762441A (en) * | 2004-10-22 | 2006-04-26 | 山西亚宝药业集团股份有限公司 | Chinese medicine composition for treating hyperlipemia and preparing method thereof |
| CN103372073A (en) * | 2012-04-20 | 2013-10-30 | 北京北大维信生物科技有限公司 | Red rice and hawthorn medicinal composition for regulating blood fat and preparation method of composition |
| CN102895268A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Lipid-lowering composition |
| CN104225466A (en) * | 2014-09-04 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicinal composition used for lowering blood lipid |
| CN104940295A (en) * | 2015-06-24 | 2015-09-30 | 天津天狮生物发展有限公司 | Blood fat reducing composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105876776A (en) * | 2016-03-24 | 2016-08-24 | 大兴安岭百盛蓝莓科技开发有限公司 | Black fungus, blueberry and red yeast rice ultrafine instant nutritious meal replacement powder and preparation method thereof |
| CN106890307A (en) * | 2017-03-21 | 2017-06-27 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
| CN106890307B (en) * | 2017-03-21 | 2018-07-10 | 中国中医科学院中医基础理论研究所 | A kind of Chinese medicine composition with effect for reducing blood fat |
| WO2018171585A1 (en) * | 2017-03-21 | 2018-09-27 | 中国中医科学院中医基础理论研究所 | Chinese medicine composition for lowering blood lipid |
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Application publication date: 20160302 |
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