CN105726625A - Traditional Chinese medicine composition used for treating dog and cat acariasis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition used for treating dog and cat acariasis and preparation method and application thereof Download PDFInfo
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- CN105726625A CN105726625A CN201610078184.2A CN201610078184A CN105726625A CN 105726625 A CN105726625 A CN 105726625A CN 201610078184 A CN201610078184 A CN 201610078184A CN 105726625 A CN105726625 A CN 105726625A
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- chinese medicine
- medicine composition
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- ethanol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
The invention provides a traditional Chinese medicine composition used for treating dog and cat acariasis.Every 100 ml of the preparation is prepared from 6-10 g of radix angelica sinensis and alcohol extracts, 5-8 g of origanum vulgare L.and alcohol extracts, 25-30 ml of glycerinum, 10-15 ml of glycerolformal, 5-10 ml of alcohol, 1 ml of azone and the balance water.The invention further provides a preparation method and application of the composition.The traditional Chinese medicine composition has the advantages of being safe, effective, low in toxicity, free of pollution and the like in the aspect of dog and cat acariasis treatment.Meanwhile, the traditional Chinese medicine composition can kill parasites to relieve itching, promote recovery of harmed fur and reduce the risks that fur is damage and people are infected with acariasis.The traditional Chinese medicine composition is free of residues during use, is simple in preparation technology, low in cost and capable of being conveniently prepared into various preparations.The traditional Chinese medicine composition is convenient to use and only need to be smeared or sprayed on the affected portions, the healing rate is as high as 80%, and the effective rate reaches 90% or above.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of for treat dog, the Chinese medicine composition of cat acaricide and
Preparation method and application.
Background technology
Pet dog, cat acariasis are a kind of common dermatosiss, point acaricide, otodectic mange and demodicidosis 3 type,
Symptom is more common in the positions such as the head of house pet, neck, tail.It is that it is main that the depilation incrustation of chronic dermatitis, pruritus, affected part and whole body are smelt as of rotten fish
Characteristics of lesion.The acaricide of house pet mostly occurs in the winter time, late fall and early spring.Due to sunlight underexposure, pet hair dense and
Long, particularly in dark moist doghouse, the beneficially growth of acarid and breeding.Healthy dogs and sick dog contact or healthy dogs
Contact with by the object of pathogen contamination, be all highly susceptible to infect, thus cause the generation of disease.If ill dog, cat are too late
Time treatment, will cause become thin, handicapped, even dead serious consequence.This disease is the most special due to the parasitic site of polypide
Very, spread speed is fast, prevents and treat just to seem more difficult, have a strong impact on house pet growth, grow, production etc., to doting on
Thing dog, the aquaculture of cat cause huge harm, simultaneously as acaricide can infect the mankind, pet dog, cat acaricide can provisions
The person of growing brings potentially hazardous and infects, and affects human health.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of for treating dog, the Chinese medicine of cat acaricide
Compositions, this medicine has prevention and therapeutic effect to acaricide, has killing parasites for relieving itching, promotes that damaged skin recovers, residual without medicine
Stay, the advantage that toxic and side effects is little.The present invention also provides for its preparation method and application.
First purpose of the present invention is to provide a kind of for treating dog, the Chinese medicine composition of cat acaricide, every 100ml preparation
It is made up of following component: Radix Angelicae Sinensis ethanol extraction 6-10g, Adeps Bovis seu Bubali ethanol extraction 5-8g, glycerol 25-30ml, glycerol acetonide first
Aldehyde 10-15ml, ethanol 5-10ml, azone 1ml, add water to 100ml.
As preferably, every 100ml preparation is made up of following component: Radix Angelicae Sinensis ethanol extraction 6g, Adeps Bovis seu Bubali ethanol extraction
5g, glycerol 25ml, glycerol formal 10ml, ethanol 5ml, azone 1ml, add water to 100ml.
As preferably, every 100ml preparation is made up of following component: Radix Angelicae Sinensis ethanol extraction 10g, Adeps Bovis seu Bubali ethanol extraction
8g, glycerol 30ml, glycerol formal 15ml, ethanol 10ml, azone 1ml, add water to 100ml.
As preferably, every 100ml preparation is made up of following component: Radix Angelicae Sinensis ethanol extraction 8g, Adeps Bovis seu Bubali ethanol extraction
6g, glycerol 28ml, glycerol formal 12ml, ethanol 8ml, azone 1ml, add water to 100ml.
Second object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition, is carried by the Radix Angelicae Sinensis ethanol of formula ratio
Take thing, Adeps Bovis seu Bubali ethanol extraction is dissolved in the ethanol of formula ratio, adds the glycerol of formula ratio, glycerol formal, azone, and mixing is all
Even, then slowly add the water of formula ratio, constant volume, grinding stirring while adding, be allowed to uniform, to obtain final product.
Third object of the present invention is to provide above-mentioned Chinese medicine composition answering in the medicine of dog, cat acaricide is treated in preparation
With.
Fourth object of the present invention is to provide a kind of medicine, its effective ingredient be claim 1-4 arbitrary described in
Drug composition.
As preferably, the dosage form of described medicine is Emulsion.
In the present invention, Radix Angelicae Sinensis has the effects such as replenishing and activating blood, pain relieving, modern pharmacological research show its have antiinflammatory, antibacterial,
Analgesia and the effect such as raising immunity of organisms and promotion skin recovery；Adeps Bovis seu Bubali has the effects such as clearing away heat and expelling pathogen in the exterior, regulating QI to expel dampness, research
Show that Adeps Bovis seu Bubali contains more than 30 kind of antimicrobial component, there is the effects such as antibacterial, antiinflammatory, antifungal, be a kind of potential natural antibiotics
With medicine growth promoter；In the Chinese medicine composition of the present invention, the merging of Radix Angelicae Sinensis and Adeps Bovis seu Bubali uses while pressing down mite killing worm,
It can also promote the recovery of the impaired fur of animal, reduces the loss brought by acarid.The interpolation of glycerol formal and ethanol promotees
Enter using of dissolving and the transdermal effect of Chinese medicine ethanol extraction, glycerol and azone and promote that animal is to the absorption of medicine and transdermal.
The Chinese medicine composition of the present invention has safely, effectively in terms for the treatment of dog, cat acaricide, toxicity is low, pollution-free etc. excellent
Point；At the same time it can also be killing parasites for relieving itching, the recovery of the impaired fur of promotion, reduce fur damage and infect the risk factor of people；This
The in use noresidue of bright Chinese medicine composition, preparation technology is simple, and low cost is conveniently prepared as various preparation；It is easy to use,
Directly it is coated with and puts affected part, affected part on the skin；Cure rate is up to 80%, and effective percentage reaches 90%.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiment
Method, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is city
Sell.
The formula of the Chinese medicine composition for treating dog, cat acaricide of the present invention is as follows:
Radix Angelicae Sinensis ethanol extraction 6-10g, Adeps Bovis seu Bubali ethanol extraction 5-8g, glycerol 25-30ml, glycerol formal 10-15ml, ethanol
5-10ml, azone 1ml, add water to 100ml.
Wherein, Radix Angelicae Sinensis ethanol extraction preparation method: take Radix Angelicae Sinensis medical material 10 weight portion, add 95% ethanol of 10 times of weight, leaching
After steeping overnight, heating and refluxing extraction three times, each 2h, sucking filtration removes impurity in extracting solution, and Rotary Evaporators concentrates, and concentrated solution exists
Water-bath is flung to ethanol, dried in vacuum drying oven, obtain Radix Angelicae Sinensis ethanol extraction.
Adeps Bovis seu Bubali ethanol extraction preparation method: take Adeps Bovis seu Bubali medical material 10 weight portion, adds 95% ethanol of 10 times of weight, soaked
After night, heating and refluxing extraction three times, each 2h, sucking filtration removes impurity in extracting solution, and Rotary Evaporators concentrates, and concentrated solution is in water-bath
Ethanol is flung in Guo, dried in vacuum drying oven, obtain Adeps Bovis seu Bubali ethanol extraction.
The preparation method of the Chinese medicine composition for treating dog, cat acaricide of the present invention is:
Radix Angelicae Sinensis ethanol extraction 6-10g, Adeps Bovis seu Bubali ethanol extraction 5-8g are dissolved in 5-10ml ethanol, addition 25-30ml glycerol,
10-15ml glycerol formal, 1ml azone, mix homogeneously, the most slowly add water, be settled to 100ml, grinding stirring while adding,
It is allowed to uniform, obtains Emulsion.
The preparation embodiment of the Chinese medicine composition of the embodiment 1-3 present invention
The Chinese medicine composition of the present invention carries out proportioning according to embodiment data each in table 1.
Each constituent content in table 1 embodiment 1-3
The preparation method of the Chinese medicine composition of the present invention is:
The Radix Angelicae Sinensis ethanol extraction of formula ratio, Adeps Bovis seu Bubali ethanol extraction are dissolved in the ethanol of formula ratio, add the sweet of formula ratio
Oil, glycerol formal, azone, mix homogeneously, then slowly add the water of formula ratio, constant volume, grinding stirring while adding, be allowed to equal
Even, obtain Emulsion.
The effect experimental of the Chinese medicine composition of embodiment 4 present invention
1. experimental animal
Qi Lihe district, Lanzhou pet clinic dog 50.
2. medicine
Test drug: extract the Emulsion medicine of preparation for previous embodiment.
Comparison medicine: ivermectin injection, Shanxi animal pharmaceutical factory produces.
3. test method
50 dogs of natural infection acarid are randomly divided into five groups, and first group real to the affected part uniform application suffering from demodicid mite dog every three days
Execute example 1 medicine 5ml, smear three times altogether；Second group every three days to suffering from the affected part uniform application embodiment 2 medicine 5ml of demodicid mite dog, altogether
Smear three times；3rd group every three days to suffering from the affected part uniform application embodiment 3 medicine 5ml of demodicid mite dog, smear three times altogether；4th group
As drug control group, ivermectin injection 0.2mg/kg, every three days subcutaneous injections once, totally three times；5th group of conduct
Blank group, every three days to adjuvant 5ml such as the affected part uniform application glycerol suffering from acaricide dog, smears three times.Above-mentioned each group is total to
Observe 15 days.
4. curative effect determinate standard
Recovery from illness: the affected part suffering from acaricide dog has no that crust or crust reduce, scrapes a small amount of skin and examines under a microscope and have no polypide,
And fur recovers good；
Taking a turn for the better: the affected part crust suffering from acaricide dog reduces, scraping a small amount of skin, to examine under a microscope polypide less, and fur is
Recover；
Invalid: the affected part crust suffering from acaricide dog has no minimizing, and basis of microscopic observation polypide has no minimizing, even increases, and fur
Have no improvement.
5 results
The Chinese medicine composition of the application present invention is smeared embodiment and is 10 examples, and cure rate is respectively 70%, 80% and 70%, the most effectively
Rate is 90%, 90% and 90%.The cure rate of drug control group (experimental group 4) is only 60%, and total effective rate 80% is below embodiment
Group；Meanwhile, blank group aggravation.The Drug therapy dog acaricide of the present invention has good effect as can be seen from the results
Really.Refer to table 2.
The effect to dog acaricide of table 2 different pharmaceutical
The effect experimental of the Chinese medicine composition of embodiment 5 present invention
1. experimental animal
Chengguan District of Lanzhou, China pet clinic cat 50.
2. medicine
Test drug: extract the Emulsion medicine of preparation for previous embodiment.
Comparison medicine: ivermectin injection, Shanxi animal pharmaceutical factory produces.
3. test method
By infect acarid 50 cats be randomly divided into five groups, first group every three days to the affected part uniform application embodiment suffering from demodicid mite cat
1 medicine 5ml, smears three times altogether；Second group every three days to suffering from the affected part uniform application embodiment 2 medicine 5ml of demodicid mite cat, smear altogether
Three times；3rd group every three days to suffering from the affected part uniform application embodiment 3 medicine 5ml of demodicid mite cat, smear three times altogether；4th group of conduct
Drug control group, ivermectin injection 0.2mg/kg, every three days subcutaneous injections once, totally three times；5th group as blank
Matched group, every three days to adjuvant 5ml such as the affected part uniform application glycerol suffering from acaricide cat, smears three times.Observe altogether for above-mentioned each group
15 days.
4. curative effect determinate standard
Recovery from illness: the affected part suffering from acaricide cat has no that crust or crust reduce, scrapes a small amount of skin and examines under a microscope and have no polypide,
And fur recovers good；
Taking a turn for the better: the affected part crust suffering from acaricide cat reduces, scraping a small amount of skin, to examine under a microscope polypide less, and fur is
Recover；
Invalid: the affected part crust suffering from acaricide cat has no minimizing, and basis of microscopic observation polypide has no minimizing, even increases, and fur
Have no improvement.
5 results
The Chinese medicine composition of the application present invention is smeared embodiment and is 10 examples, and cure rate is respectively 70%, 80% and 70%, the most effectively
Rate is 90%, 100% and 90%.The cure rate of drug control group (experimental group 4) is only 70%, and total effective rate 90% is equal to or is less than
Embodiment group；Meanwhile, blank group aggravation.The Drug therapy cat acaricide of the present invention has well as can be seen from the results
Effect.Refer to table 3.
The effect to cat acaricide of table 3 different pharmaceutical
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, although
Being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still can be right
Technical scheme described in foregoing embodiments is modified, or wherein portion of techniques feature is carried out equivalent.All
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the protection of the present invention
Within the scope of.
Claims (8)
1. one kind is used for treating dog, the Chinese medicine composition of cat acaricide, it is characterised in that: every 100ml preparation is by following component group
Become: Radix Angelicae Sinensis ethanol extraction 6-10g, Adeps Bovis seu Bubali ethanol extraction 5-8g, glycerol 25-30ml, glycerol formal 10-15ml, ethanol
5-10ml, azone 1ml, add water to 100ml.
Chinese medicine composition the most according to claim 1, it is characterised in that: every 100ml preparation is made up of following component: when
Return ethanol extraction 6g, Adeps Bovis seu Bubali ethanol extraction 5g, glycerol 25ml, glycerol formal 10ml, ethanol 5ml, azone 1ml, add water
To 100ml.
Chinese medicine composition the most according to claim 1, it is characterised in that: every 100ml preparation is made up of following component: when
Return ethanol extraction 10g, Adeps Bovis seu Bubali ethanol extraction 8g, glycerol 30ml, glycerol formal 15ml, ethanol 10ml, azone 1ml, add
Water is to 100ml.
Chinese medicine composition the most according to claim 1, it is characterised in that: every 100ml preparation is made up of following component: when
Return ethanol extraction 8g, Adeps Bovis seu Bubali ethanol extraction 6g, glycerol 28ml, glycerol formal 12ml, ethanol 8ml, azone 1ml, add water
To 100ml.
5. the preparation method of the arbitrary described Chinese medicine composition of claim 1-4, it is characterised in that: by the Radix Angelicae Sinensis ethanol of formula ratio
Extract, Adeps Bovis seu Bubali ethanol extraction are dissolved in the ethanol of formula ratio, add the glycerol of formula ratio, glycerol formal, azone, mixing
Uniformly, then slowly add the water of formula ratio, constant volume, grinding stirring while adding, be allowed to uniform, to obtain final product.
6. the application in the medicine of dog, cat acaricide is treated in preparation of the Chinese medicine composition described in claim 5.
7. a medicine, its effective ingredient is the arbitrary described Chinese medicine composition of claim 1-4.
Medicine the most according to claim 7, it is characterised in that: the dosage form of described medicine is Emulsion.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610078184.2A CN105726625A (en) | 2016-02-04 | 2016-02-04 | Traditional Chinese medicine composition used for treating dog and cat acariasis and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610078184.2A CN105726625A (en) | 2016-02-04 | 2016-02-04 | Traditional Chinese medicine composition used for treating dog and cat acariasis and preparation method and application thereof |
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Family
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209722A (en) * | 2021-12-31 | 2022-03-22 | 四川农业大学 | Application of angelica essential oil in preparation of medicine or daily chemical product with mite removing effect |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385927A (en) * | 2013-07-16 | 2013-11-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for the treatment of animal acariasis |
-
2016
- 2016-02-04 CN CN201610078184.2A patent/CN105726625A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103385927A (en) * | 2013-07-16 | 2013-11-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for the treatment of animal acariasis |
Non-Patent Citations (1)
| Title |
|---|
| 李钧 等: ""1.5%MC-3100霜剂对人面部螨虫皮炎的功效研究"", 《2010国际化妆品高峰论坛》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209722A (en) * | 2021-12-31 | 2022-03-22 | 四川农业大学 | Application of angelica essential oil in preparation of medicine or daily chemical product with mite removing effect |
| CN114209722B (en) * | 2021-12-31 | 2022-09-23 | 四川农业大学 | Application of angelica essential oil in preparation of medicine or daily chemical product with mite removing effect |
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Application publication date: 20160706 |