CN108567864A - Chinese medicine preparation for treating sore mouth virus - Google Patents
Chinese medicine preparation for treating sore mouth virus Download PDFInfo
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- CN108567864A CN108567864A CN201810609117.8A CN201810609117A CN108567864A CN 108567864 A CN108567864 A CN 108567864A CN 201810609117 A CN201810609117 A CN 201810609117A CN 108567864 A CN108567864 A CN 108567864A
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract
The invention belongs to technical field of animal husbandry more particularly to a kind of Chinese medicine preparations for treating sore mouth virus.The Chinese medicine preparation is the Chinese medicine composition for treating sore mouth virus, composed of the following components by weight：40 100 parts of cornu bubali, 90 150 parts of Radix Rehmanniae, 30 80 parts of Armstrong, 50 120 parts of the coptis, 40 110 parts of radix scutellariae, 50 120 parts of plantain seed, 50 120 parts of cape jasmine, 5 20 parts of Lygodium japonicum, 50 120 parts of Fructus Forsythiae, 40 110 parts of campanulaceae, 50 120 parts of honeysuckle, 30 80 parts of dianthus superbus, 80 150 parts of rush, 10 30 parts of 50 90 parts of field pennycress, 30 80 parts of sweet basil and blackberry lily.The Chinese medicine composition is better than the prior art to the therapeutic effect of sore mouth virus, is the further prevention based theoretical of sore mouth virus.The Chinese medicine composition does not have any toxic side effect, medicinal material easily to obtain, at low cost.
Description
Technical field
The invention belongs to technical field of animal husbandry more particularly to a kind of Chinese medicine preparations for treating sore mouth virus.
Background technology
Sheep infective warts is commonly called as sore mouth virus, is a kind of infectious disease that sheep caused by sheep infective pustule virus occurs.Face
Bed can be divided into lip type, style of the shoe, outer female, and goat aphtha disease belongs to one kind in Poxviridae, in negative staining sample, virion
Feature with Coiling-type.This disease is mainly in 3-6 months lambs, and normal Cheng Qunfa has certain disease-resistant energy into age sheep
Power.Sick sheep is infected with lip portion for cardinal symptom.The small red stain being dispersed on bicker, upper lip or asoscope first, after
Papule, tubercle are gradually become, blister or warts are then formed, is spread to around entire lip and the portions such as face, eyelid and auricle.
Sick sheep is reluctant to search for food due to pain, and performance salivation, spirit is tired, anorexia or useless exhausted, ruminates reductions, hair slightly unrest nothing
Light, day are gradually thin.The breast of wet sheep may also same illness, mainly infected since lamb is bitten.In recent years, the disease
There is outburst in multiple areas at home.The drug for being presently used for treatment sore mouth virus is relatively fewer, is brought to the prevention of the disease huge
Difficulty brings larger economic loss to sheep husbandry.
Currently, the research of antiviral natural drug has become hot spot.It is anti-that various biological technology is used for Large-scale Screening
Viral Chinese medicine, mainly by being detected to body antibody level, blood parameters, hormonal readiness, Molecular biology
Analyze influence of the Chinese medicine to animal body immune system, digestion and metabolism system.Such as application No. is 201310486476.6 inventions
Patent discloses a kind of Chinese herbal medicine formula preventing goat aphtha, which consists of the following compositions by weight percentage：Tongue is joined
4%, imperial born of the same parents 5%, Bai Jian 5%, Chinese prickly ash 6%, Hypericum beanii 4%, borneol 5%, borax 30%, saltcake 5%, calamitas urinae hominis 4%, calculus bovis factitius 6%, blueness
Black pigment used by women in ancient times to paint their eyebrows 4%, gypsum 5%, Cortex Phellodendri 4%, the coptis 2%, campanulaceae 2%, catechu 2%, excess water to 100%.Find that formula prevention is reachable through practice
To 95% or more, especially to being begun in the flock of sheep prevented from lamb, basic preventive effect can reach 100%, and not
There is any side effect, is suitable for large-scale farming.For another example application No. is 201510533885.6 patents of invention to disclose one kind
The drug of sore mouth virus is treated, which is made of the raw material of following parts by weight：Ilex viridis Champ 1-2 parts by weight, adiantum cpilus-veneris 1-2
Parts by weight, Salvia japonica 0.5-1 parts by weight, sweet basil 0.5-1 parts by weight.The medicine preparation is at topical administration formulations, preparation method：It is dry
Dry Ilex viridis Champ, adiantum cpilus-veneris, Salvia japonica, sweet basil, for the first time plus 11 times of amount water impregnate 1 hour, decoct 1 hour, second plus 4
Amount water decocts 1 hour again, merges decocting liquid, filtration, and filtrate adds 50% ethyl alcohol, drug liniment is made.
Most of medicinal herb components all have preferable antiviral effect, as honeysuckle infects and exhales in anti-alimentary tract virus
Tool has a better effect when inhaling the infection of road virus, and Radix Astragali infected by influenza etc. has certain inhibition.Currently, about heat-clearing
The research of antidote is relatively more, but really relatively fewer for treating the Chinese medicine of sore mouth virus.Present inventor is based on
An article has been delivered in the research of its early stage《Primary Study of three kinds of Chinese medicine compound prescriptions to sore mouth virus function and effect》, remember in this article
It has carried by anti-inflammatory analgesic, clearing heat and detoxicating, hepatic cholagogic, enhancing are immune and three kinds of Chinese medicines filtering out for the purpose of whetting the appetite are multiple
Side selects three kinds of Chinese medicine compound prescriptions to handle sore mouth virus case, and to treated sheep Biochemical Indices In Serum, associated hormone
Index and weight are for statistical analysis, the results showed that, three kinds of Chinese medicine compound prescriptions have the effect for controlling the disease, and with Chinese medicine compound prescription II
It is optimal to the therapeutic effect of sore mouth virus.Present inventor further gos deep into compound II by experimental study and clinical observation
Research, explores its therapeutic effect to sore mouth virus, and improved compound formula, it was found that a kind of sore mouth virus for the treatment of more has
The Chinese medicine composition of effect is the further prevention based theoretical of sore mouth virus.
This case is divisional application, female case it is entitled《Treat the Chinese medicine composition of sore mouth virus》, application No. is
201610200026.x the applying date is on April 1st, 2016.
Invention content
In view of this, treating sore mouth virus effect more preferably Chinese medicine composition the purpose of the present invention is to provide a kind of, in this
Drug composition is that gained is further improved on the basis of existing research, and therapeutic effect is better than the prior art.
To achieve the above object, the technical scheme is that：
The Chinese medicine composition of sore mouth virus is treated, it is composed of the following components by weight：
40-100 parts of cornu bubali, 90-150 parts of Radix Rehmanniae, 30-80 parts of Armstrong, 50-120 parts of the coptis, 40-110 parts of radix scutellariae, plantain seed
50-120 parts, 50-120 parts of cape jasmine, 5-20 parts of Lygodium japonicum, 50-120 parts of Fructus Forsythiae, 40-110 parts of campanulaceae, 50-120 parts of honeysuckle,
30-80 parts of dianthus superbus.
Further, the Chinese medicine composition, it is composed of the following components by weight：
50-80 parts of cornu bubali, 100-130 parts of Radix Rehmanniae, 40-60 parts of Armstrong, 70-110 parts of the coptis, 60-100 parts of radix scutellariae, plantain seed
70-110 parts, 70-110 parts of cape jasmine, 10-15 parts of Lygodium japonicum, 70-110 parts of Fructus Forsythiae, 50-80 parts of campanulaceae, 70-100 parts of honeysuckle,
40-70 parts of dianthus superbus.
Further, the Chinese medicine composition, it is composed of the following components by weight：
60 parts of cornu bubali, 120 parts of Radix Rehmanniae, 50 parts of Armstrong, 80 parts of the coptis, 70 parts of radix scutellariae, 90 parts of plantain seed, 80 parts of cape jasmine, Hai Jin
It is 10 parts husky, 80 parts of Fructus Forsythiae, 70 parts of campanulaceae, 80 parts of honeysuckle, 50 parts of dianthus superbus.
The present invention also protects the Chinese medicine composition preparing the application in treating sore mouth virus drug, Chinese medicine of the invention
Composition has a better effect sore mouth virus tool.
The present invention also protects the pharmaceutical preparation of any treatment sore mouth virus prepared by the Chinese medicine composition of the present invention, the system
Agent is the achievable any dosage form in this field, such as powder, granule, aqua.
In one particular embodiment of the present invention, a kind of powder is specifically disclosed, preparation method is：Chinese medicine composition
All drugs through crusher for Chinese herbal medicine smash it through 40-120 mesh sieve, mix to obtain Chinese traditional medicine composition composition powders thoroughly.The use of the powder
Method is to be made an addition in sheep feed to be fed, and is fed generally according to 0.5% additive amount, but the addition of powder
Amount can be taken the circumstances into consideration to add or reduced by feeding personnel according to sheep size, state of an illness situation and feeding time, until fully recovering.
Present inventor also found, when the Chinese medicine composition is used cooperatively with another composition, effect is more
Good, there is synergistic effect in the two.
Therefore, further, the Chinese medicine composition of the treatment sore mouth virus, the Chinese medicine composition and cooperative compositions B
It is used cooperatively, the cooperative compositions B is composed of the following components by weight：80-150 parts of rush, field pennycress 50-90
10-30 parts of part, 30-80 parts of sweet basil and blackberry lily.
Preferably, the cooperative compositions B is composed of the following components by weight：100-130 parts of rush, field pennycress
60-80 parts, 40-60 parts of sweet basil, blackberry lily 20-30.
It is furthermore preferred that the cooperative compositions B is composed of the following components by weight：120 parts of rush, field pennycress 70
Part, 50 parts of sweet basil, blackberry lily 25.
Since the Chinese medicine composition and cooperative compositions B have synergistic effect, the present invention also protect described in
Drug composition is used cooperatively with cooperative compositions B and is preparing the application in treating sore mouth virus drug, and the two is used cooperatively to Yang Kou
More preferably, the cooperative compositions B is composed of the following components by weight for sore therapeutic effect：80-150 parts of rush, field pennycress
10-30 parts of 50-90 parts, 30-80 parts of sweet basil and blackberry lily.
Further, described the present invention also provides the method that the Chinese medicine composition and cooperative compositions B are used cooperatively
Cooperative compositions B is composed of the following components by weight：80-150 parts of rush, 50-90 parts of field pennycress, 30-80 parts of sweet basil
With 10-30 parts of blackberry lily；The method is：
（1）All drugs of Chinese medicine composition smash it through 40-120 mesh sieve through crusher for Chinese herbal medicine, mix to obtain Chinese medicine composition thoroughly
Powder；
（2）Cooperative compositions B is mixed by above-mentioned parts by weight, is boiled 20-60 minutes after the water of 1-3 times of weight is added, and is filtered
Obtain filtrate；
（3）Step is added in sheep feed（1）The Chinese traditional medicine composition composition powders of gained are fed, and step is gavaged after each feeding
（2）The filtrate of gained.
Wherein the additive amount of powder is fed generally according to 0.5% additive amount, but the additive amount of powder can be by feeding
Personnel take the circumstances into consideration to add or reduce according to sheep size, state of an illness situation and feeding time, until fully recovering.Similarly, filtrate is gavaged
It is carried out generally according to the amount of each 20-30ml, but also can be by feeding personnel according to sheep size, state of an illness situation and feeding time
It adds or reduces as one sees fit, until fully recovering.
Further, all drugs of the method, Chinese medicine composition smash it through 60-80 mesh through crusher for Chinese herbal medicine
Sieve.
Further, in order to keep drug-eluting more abundant, in the method, step（2）In, cooperative compositions B can be into
Row impregnates in advance, also can repeatedly add boiling boiling, be then combined with filtrate.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention clearer, below to the preferred embodiment of the present invention into
The detailed description of row.
Animal sheep involved in following embodiment is only boer goat, is selected from Chongqing Rongchang County Yang Chang.
Test the selection of sheep only：
Specific primer is designed with reference to the sheep of virus memebrane protein F1L gene orders announced in NCBI, will be come from same
Only, acquisition port lip crust carries out cause of disease to sheep similar in the size of the doubtful sheep infective pustule virus infection of sheep same breed
PCR Molecular Identifications, and PCR product is sent to raw work bioengineering（Shanghai）Limited liability company is sequenced.Sheep is tested only to exist
Occur expected positive band at about 1000 positions bp, finds that size is 1023 bp after sequencing, through BLAST in NCBI
It compares and finds, be 100% with sheep of virus F1L gene order similarities, and then determine that on-demand experiment sheep is only sheep
The illness sheep of infective pustule virus infection is only.
Embodiment 1 treats the Traditional Chinese medicine composition formula of sore mouth virus
It is formulated A:
It is composed of the following components by weight：
50 parts of cornu bubali, 90 parts of Radix Rehmanniae, 40 parts of Armstrong, 70 parts of the coptis, 60 parts of radix scutellariae, 70 parts of plantain seed, 110 parts of cape jasmine, Hai Jin
It is 15 parts husky, 120 parts of Fructus Forsythiae, 80 parts of campanulaceae, 100 parts of honeysuckle, 70 parts of dianthus superbus.
It is formulated B:
It is composed of the following components by weight：
80 parts of cornu bubali, 130 parts of Radix Rehmanniae, 60 parts of Armstrong, 110 parts of the coptis, 100 parts of radix scutellariae, 110 parts of plantain seed, 70 parts of cape jasmine, sea
10 parts of Jinsha, 70 parts of Fructus Forsythiae, 50 parts of campanulaceae, 70 parts of honeysuckle, 40 parts of dianthus superbus.
It is formulated C:
It is composed of the following components by weight：
60 parts of cornu bubali, 120 parts of Radix Rehmanniae, 50 parts of Armstrong, 80 parts of the coptis, 70 parts of radix scutellariae, 90 parts of plantain seed, 80 parts of cape jasmine, Hai Jin
It is 10 parts husky, 80 parts of Fructus Forsythiae, 70 parts of campanulaceae, 80 parts of honeysuckle, 50 parts of dianthus superbus.
It is formulated D:
It is composed of the following components by weight：
60 parts of cornu bubali, 120 parts of Radix Rehmanniae, 80 parts of the coptis, 70 parts of radix scutellariae, 80 parts of cape jasmine, 80 parts of Fructus Forsythiae, 70 parts of campanulaceae, honeysuckle
80 parts, 50 parts of dianthus superbus.
2 sore mouth virus of embodiment treats effectiveness study
（1）The preparation of drug
By all drugs through crusher for Chinese herbal medicine smash it through 40 mesh sieve, respectively according to formula A, B, C, D in embodiment 1 into
Row is prepared, and is mixed thoroughly, spare.
（2）Having determined that from same sheep same breed is tested similar in infection sheep infective pustule virus and size
Sheep is only equally divided into four groups, and every group 10, optionally 10 Healthy Sheeps are as Normal group.It is added respectively in testing sheep feed
It is formulated the drug of A, B, C, D, is fed according to 0.5% additive amount, stops addition Chinese medicine after 20 d, one is kept with Normal group
The feed mode of cause observes and records the rehabilitation situation of sheep only.
After only being treated to sheep with the drug of formula A, B, C, D, as a result：
A, B, C group sheep only whole rehabilitations, the whole rehabilitation durations of sheep were at 10-12 days, and D group rehabilitations sheep is only 6, rehabilitation duration
It is 16-18 days.
In addition, reference《Primary Study of three kinds of Chinese medicine compound prescriptions to sore mouth virus function and effect》[HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE science and technology
Version, animal health-care product, 2015 October（On）208-210 pages] in method, after feeding 20 days, acquisition experiment sheep only reaches pair
According to a group serum, it is sent to hospital general of Chongqing Yongrong Mining Co., Ltd. and carries out index of correlation（Enzyme in serum）Detection and analysis, pass through
Biochemical Indices In Serum is tested and analyzed and is found, lactic dehydrogenase, alkaline phosphatase, white egg in the sheep serum of A, B, C group processing
In vain, gpt level is significantly higher than blank control group Healthy Sheep only, and lactic dehydrogenase in the sheep serum that D groups are handled,
Alkaline phosphatase, albumin, gpt level with blank control group Healthy Sheep only compared with difference it is not notable.
3 Chinese medicine composition of embodiment is used cooperatively with cooperative compositions B
（1）Chinese medicine composition is composed of the following components by weight：
60 parts of cornu bubali, 120 parts of Radix Rehmanniae, 50 parts of Armstrong, 80 parts of the coptis, 70 parts of radix scutellariae, 90 parts of plantain seed, 80 parts of cape jasmine, Hai Jin
It is 10 parts husky, 80 parts of Fructus Forsythiae, 70 parts of campanulaceae, 80 parts of honeysuckle, 50 parts of dianthus superbus；By all drugs of Chinese medicine composition through Chinese herbal medicine powder
Broken machine smashes it through 60 mesh sieve, mixes to obtain Chinese traditional medicine composition composition powders thoroughly；
（2）The cooperative compositions B is composed of the following components by weight：120 parts of rush, 70 parts of field pennycress, sweet basil 50
Part, 25 parts of blackberry lily；Cooperative compositions B is mixed by above-mentioned parts by weight, is boiled 20-60 minutes after the water of 1-3 times of weight is added,
It filters to get filtrate；
（3）By having determined that from same sheep same breed, experiment sheep is only similar in infection sheep infective pustule virus and size
It is equally divided into two groups of E, F, every group 10, optionally 10 Healthy Sheeps are as Normal group.Chinese medicine is added in E groups experiment sheep feed
Composition powders are combined, are fed according to 0.5% additive amount, F groups, which are tested, adds Chinese traditional medicine composition composition powders in sheep feed, according to 0.5%
Additive amount is fed, and gavages 20ml steps after each feeding（2）The filtrate of gained.Stop addition Chinese medicine composition after 20d
And stop gavaging liquid, the feed mode being consistent with Normal group, observe and record the rehabilitation situation of sheep only.As a result table
Bright, the only whole rehabilitations of E groups sheep, only whole rehabilitation durations are 10 days to sheep, and the only whole rehabilitations of F groups sheep, only whole rehabilitation durations are 5 to sheep
It.Also, it is found by being tested and analyzed to Biochemical Indices In Serum, lactic dehydrogenase, alkaline phosphatase in the sheep serum of F groups processing
Enzyme, albumin, gpt level are significantly higher than E groups.
In the present embodiment, Chinese medicine composition proportioning is optimum proportioning, present inventor with cooperative compositions B proportionings
Also other proportionings of Chinese medicine composition and cooperative compositions B are tested, the results showed that, the only whole rehabilitations of experiment sheep,
Only whole rehabilitation durations are 5-7 days to sheep.
Finally illustrate, the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although with reference to compared with
Good embodiment describes the invention in detail, it will be understood by those of ordinary skill in the art that, it can be to the skill of the present invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of technical solution of the present invention, should all be covered at this
In the right of invention.
Claims (5)
1. treating the Chinese medicine composition of sore mouth virus, which is characterized in that composed of the following components by weight：
40-100 parts of cornu bubali, 90-150 parts of Radix Rehmanniae, 30-80 parts of Armstrong, 50-120 parts of the coptis, 40-110 parts of radix scutellariae, plantain seed
50-120 parts, 50-120 parts of cape jasmine, 5-20 parts of Lygodium japonicum, 50-120 parts of Fructus Forsythiae, 40-110 parts of campanulaceae, 50-120 parts of honeysuckle,
10-30 parts of 30-80 parts of dianthus superbus, 80-150 parts of rush, 50-90 parts of field pennycress, 30-80 parts of sweet basil and blackberry lily.
2. Chinese medicine composition according to claim 1, which is characterized in that composed of the following components by weight：
40-100 parts of cornu bubali, 90-150 parts of Radix Rehmanniae, 30-80 parts of Armstrong, 50-120 parts of the coptis, 40-110 parts of radix scutellariae, plantain seed
50-120 parts, 50-120 parts of cape jasmine, 5-20 parts of Lygodium japonicum, 50-120 parts of Fructus Forsythiae, 40-110 parts of campanulaceae, 50-120 parts of honeysuckle,
30-80 parts of dianthus superbus, 100-130 parts of rush, 60-80 parts of field pennycress, 40-60 parts of sweet basil and blackberry lily 20-30.
3. Chinese medicine composition according to claim 2, which is characterized in that composed of the following components by weight：
40-100 parts of cornu bubali, 90-150 parts of Radix Rehmanniae, 30-80 parts of Armstrong, 50-120 parts of the coptis, 40-110 parts of radix scutellariae, plantain seed
50-120 parts, 50-120 parts of cape jasmine, 5-20 parts of Lygodium japonicum, 50-120 parts of Fructus Forsythiae, 40-110 parts of campanulaceae, 50-120 parts of honeysuckle,
30-80 parts of dianthus superbus, 120 parts of rush, 70 parts of field pennycress, 50 parts of sweet basil and blackberry lily 25.
4. claim 1-3 any one of them Chinese medicine composition is preparing the application in treating sore mouth virus drug.
5. the preparation method of claim 1-3 any one of them Chinese medicine compositions, which is characterized in that the preparation method
For：
（1）Cornu bubali, Radix Rehmanniae, Armstrong, the coptis, radix scutellariae, plantain seed, cape jasmine, Lygodium japonicum, Fructus Forsythiae, campanulaceae, honeysuckle and dianthus superbus are pressed
Above-mentioned parts by weight smash it through 40-120 mesh sieve through crusher for Chinese herbal medicine respectively, mix to obtain Chinese traditional medicine composition composition powders thoroughly；
（2）Rush, field pennycress, sweet basil and blackberry lily are mixed by above-mentioned parts by weight, are boiled after the water of 1-3 times of weight is added
It 20-60 minutes, filters to get filtrate；
（3）Step is added in supporting feed（1）The Chinese traditional medicine composition composition powders of gained gavage step after feeding every time（2）Gained
Filtrate.
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| CN104208468A (en) * | 2014-08-22 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition used for treating horse aphtha |
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| CN104208468A (en) * | 2014-08-22 | 2014-12-17 | 严中明 | Traditional Chinese medicine composition used for treating horse aphtha |
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