CN102526578A - Granular medicine for treating cold - Google Patents
Granular medicine for treating cold Download PDFInfo
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- CN102526578A CN102526578A CN2012100136568A CN201210013656A CN102526578A CN 102526578 A CN102526578 A CN 102526578A CN 2012100136568 A CN2012100136568 A CN 2012100136568A CN 201210013656 A CN201210013656 A CN 201210013656A CN 102526578 A CN102526578 A CN 102526578A
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Abstract
The invention discloses a medicine for treating cold. The medicine comprises the following raw materials: radix bupleuri, honeysuckle, herba schizonepetae, perilla, folium isatidis, tangerine peel, bulbus fritillariae cirrhosae, szechuan lovage rhizome, radix glehniae, flower bud of lily magnolia, dandelion, radix puerariae, coix seed, radix astragali, liquorice, Indian buead, radix ophiopogonis, notopterygium root, chrysanthemum, blighted wheat, lotus seed meat, radix angelicae dahuricae, fructus mume, rhizoma alpiniae officinarum, stir-fried green beans and lily; the required conventional accessories such as thickener and sweetener are added into the raw materials; and common granular medicine is prepared by a conventional traditional Chinese medicine preparation method. The granular medicine disclosed by the invention has the effects of low cost, obvious curative effect, high cure rate and the like, and is easy to process and safe to use.
Description
Technical field
The present invention relates to the field of Chinese medicines, being specifically related to a kind of is the granule medicament of raw material treatment flu with Chinese medicine.
Background technology
Flu is common, multiple and the epidemic disease very harmful to the mankind.The generation of influenza is many because of due to the influenza virus, and it is few to be used to treat the influenza virus specific medicament in the world today.Mostly Western medicine class medicine of the prior art is to slow down the medicine of disease, slows down effect though can play the malaise symptoms such as caused heating, pain, cough of falling ill like the antipyretic-antalgic class medicine that generally uses, and can not play therapeutical effect to the cause of disease.In recent years, Chinese approved several kinds of new drugs that are used to treat influenza, flu, like SHUANGHUANGLIAN KELI, GANMAO QINGRE KELI etc.; Because this type of medicine has stronger inhibitory action to influenza virus; Except that can slowing down the symptom, and can shorten healing time, play the effect of treating both the principal and secondary aspects of a disease; And have no side effect, receive patient and medical personnel's welcome deeply.But compare the weak point that also existence is brought down a fever, pain relieving is slower with Western medicine class medicine.Mostly the preparation of clinical use is slightly to obtain through refining agent in addition, and it is remarkable to lack drug effect, and the effective ingredient and the mechanism of action are clear, and is quality controllable, the modern Chinese medicine that dosage form is advanced.
Summary of the invention
The object of the invention provides a kind of active constituent content high and recipe quantity is little, it is fast to bring down a fever, analgesic effect significantly is used to granule medicament of treating flu and preparation method thereof just to above-mentioned weak point of the prior art, evident in efficacy, with low cost, toxic and side effects is minimum.
Realize through following technical scheme during technical problem that the present invention will solve.
Medicament of the present invention is made up of following weight portion:
Major ingredient: Radix Bupleuri 30-50 part, Flos Lonicerae 20-40 part, Herba Schizonepetae 10-15 part, Folium Perillae 10-20 part, Folium Isatidis 5-8 part; Pericarpium Citri Reticulatae 6-10 part, Bulbus Fritillariae Cirrhosae 5-8 part, Rhizoma Chuanxiong 5-8 part, Radix Glehniae 10-15 part, Flos Magnoliae 10-15 part; Herba Taraxaci 20-30 part, Radix Puerariae 10-20 part, Semen Coicis 6-15 part, Radix Astragali 5-10 part, Radix Glycyrrhizae 11-18 part; Poria 6-10 part, Radix Ophiopogonis 10-20 part, Rhizoma Et Radix Notopterygii 3-5 part, Flos Chrysanthemi 30-40 part, Fructus Tritici Levis 10-15 part; Semen Nelumbinis 20-30 part, Radix Angelicae Dahuricae 6-10 part, Fructus Mume 10-20 part, Rhizoma Alpiniae Officinarum 8-13 part, stir-fried kidney beans 4-8 part, Bulbus Lilii 3-6 part;
Thickening agent 5-8 part, said thickening agent are any one in starch, maltodextrin, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, the carboxymethyl starch sodium;
Sweeting agent 3-5 part: said sweeting agent is any one in maltose, mannose or the xylitol.
The preferred following steps of medicament processing method of the present invention:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 60 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the powder about 100 orders, and with various powder even blend;
(4) pour in the electric-heating container powder after the mixing of step (3) gained or Steam Heating, the decocting that dosing grain weight amount is 10 times boiled 4 hours, and temperature is no more than 100 ℃, filtered medicinal residues, collected the gained medicinal liquid;
(5) water that step (4) gained medicinal residues is added 5 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(6) with twice collected combining medicine that gets, centrifugalize concentrates after removing remaining tiny medicinal residues; 80 ℃ of thickening temperatures, 1 hour time;
(7) thickening agent and the sweeting agent in the adding formula proportion fully stirs, and makes it reach concentration about 80%;
(8) spray drying forming;
(9) granulate, sieve, packing, sterilization, quality inspection, packing, obtain the finished particle agent.
Usage: oral, each 1 to 2 bag, after washing open, warm water takes, and each 2 times, 7 days is a course of treatment, and be 1-2 visual effects the course of treatment usually.
The specific embodiment
Embodiment 1
Take by weighing major ingredient and adjuvant by following proportioning:
Major ingredient: 30 parts of Radix Bupleuri, 20 parts of Flos Loniceraes, 10 parts of Herba Schizonepetae, 10 parts of Folium Perillaes, 5 parts of Folium Isatidiss, 6 parts of Pericarpium Citri Reticulataes, 5 parts of Bulbus Fritillariae Cirrhosaes; 5 parts of Rhizoma Chuanxiongs, 10 parts of Radix Glehniaes, 10 parts of Flos Magnoliaes, 20 parts of Herba Taraxacis, 10 parts of Radix Puerariaes, 6 parts of Semen Coicis, 5 parts of the Radixs Astragali; 11 parts in Radix Glycyrrhizae, 6 parts in Poria, 10 parts of Radix Ophiopogonis, 3 parts of Rhizoma Et Radix Notopterygiis, 30 parts of Flos Chrysanthemis, 10 parts of Fructus Tritici Levis; 20 parts of Semen Nelumbinis, 6 parts of the Radixs Angelicae Dahuricae, 10 parts of Fructus Mumes, 8 parts of Rhizoma Alpiniae Officinarums, 4 parts of stir-fried kidney beans, 3 parts of Bulbus Liliies;
5 parts of thickening agents, 3 parts of sweeting agents.
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 60 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the powder about 100 orders, and with various powder even blend;
(4) pour in the electric-heating container powder after the mixing of step (3) gained or Steam Heating, the decocting that dosing grain weight amount is 10 times boiled 4 hours, and temperature is no more than 100 ℃, filtered medicinal residues, collected the gained medicinal liquid;
(5) water that step (4) gained medicinal residues is added 5 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(6) with twice collected combining medicine that gets, centrifugalize concentrates after removing remaining tiny medicinal residues; 80 ℃ of thickening temperatures, 1 hour time;
(7) maltodextrin and the sucrose in the adding formula proportion fully stirs, and makes it reach concentration about 80%;
(8) spray drying forming;
(9) granulate, sieve, packing, sterilization, quality inspection, packing, obtain the finished particle agent.
Embodiment 2
Take by weighing major ingredient and adjuvant by following proportioning:
Major ingredient: 50 parts of Radix Bupleuri, 40 parts of Flos Loniceraes, 15 parts of Herba Schizonepetae, 20 parts of Folium Perillaes, 8 parts of Folium Isatidiss, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Bulbus Fritillariae Cirrhosaes; 8 parts of Rhizoma Chuanxiongs, 15 parts of Radix Glehniaes, 15 parts of Flos Magnoliaes, 30 parts of Herba Taraxacis, 20 parts of Radix Puerariaes, 15 parts of Semen Coicis, 10 parts of the Radixs Astragali; 18 parts in Radix Glycyrrhizae, 10 parts in Poria, 20 parts of Radix Ophiopogonis, 5 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Flos Chrysanthemis, 15 parts of Fructus Tritici Levis; 30 parts of Semen Nelumbinis, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Fructus Mumes, 13 parts of Rhizoma Alpiniae Officinarums, 8 parts of stir-fried kidney beans, 6 parts of Bulbus Liliies;
8 parts of sodium carboxymethyl cellulose, 5 parts of maltose.
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 60 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the powder about 100 orders, and with various powder even blend;
(4) pour in the electric-heating container powder after the mixing of step (3) gained or Steam Heating, the decocting that dosing grain weight amount is 10 times boiled 4 hours, and temperature is no more than 100 ℃, filtered medicinal residues, collected the gained medicinal liquid;
(5) water that step (4) gained medicinal residues is added 5 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(6) with twice collected combining medicine that gets, centrifugalize concentrates after removing remaining tiny medicinal residues; 80 ℃ of thickening temperatures, 1 hour time;
(7) maltodextrin and the sucrose in the adding formula proportion fully stirs, and makes it reach concentration about 80%;
(8) spray drying forming;
(9) granulate, sieve, packing, sterilization, quality inspection, packing, obtain the finished particle agent.
Embodiment 3
Take by weighing major ingredient and adjuvant by following proportioning:
Major ingredient: 44 parts of Radix Bupleuri, 35 parts of Flos Loniceraes, 12 parts of Herba Schizonepetae, 17 parts of Folium Perillaes, 6 parts of Folium Isatidiss, 8 parts of Pericarpium Citri Reticulataes, 7 parts of Bulbus Fritillariae Cirrhosaes; 7 parts of Rhizoma Chuanxiongs, 13 parts of Radix Glehniaes, 12 parts of Flos Magnoliaes, 24 parts of Herba Taraxacis, 16 parts of Radix Puerariaes, 12 parts of Semen Coicis, 8 parts of the Radixs Astragali; 14 parts in Radix Glycyrrhizae, 7 parts in Poria, 13 parts of Radix Ophiopogonis, 4 parts of Rhizoma Et Radix Notopterygiis, 34 parts of Flos Chrysanthemis, 12 parts of Fructus Tritici Levis; 22 parts of Semen Nelumbinis, 8 parts of the Radixs Angelicae Dahuricae, 13 parts of Fructus Mumes, 10 parts of Rhizoma Alpiniae Officinarums, 5 parts of stir-fried kidney beans, 4 parts of Bulbus Liliies;
7 parts of starch, 4 parts in mannitol.Medicament processing method of the present invention is carried out as follows:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 60 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the powder about 100 orders, and with various powder even blend;
(4) pour in the electric-heating container powder after the mixing of step (3) gained or Steam Heating, the decocting that dosing grain weight amount is 10 times boiled 4 hours, and temperature is no more than 100 ℃, filtered medicinal residues, collected the gained medicinal liquid;
(5) water that step (4) gained medicinal residues is added 5 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(6) with twice collected combining medicine that gets, centrifugalize concentrates after removing remaining tiny medicinal residues; 80 ℃ of thickening temperatures, 1 hour time;
(7) maltodextrin and the sucrose in the adding formula proportion fully stirs, and makes it reach concentration about 80%;
(8) spray drying forming;
(9) granulate, sieve, packing, sterilization, quality inspection, packing, obtain the finished particle agent.
Medicine of the present invention proves through pharmacological testing: to draft beer yeast and 2,2, 4-dinitrophenol causes rat fever, and these article all can obviously reduce laboratory animal body temperature; The skin of abdomen capillary permeability that mice auricular concha swelling that can suppress to be caused by xylene and histamine phosphate cause increases, and tangible antiinflammatory action is arranged.External bacteriostatic experiment shows that these article all have the obvious suppression effect to staphylococcus aureus, Bacillus typhi, escherichia coli, Shigella flexneri, bacillus pyocyaneus, Bacillus proteus.To influenza virus A, B and become strain, respiratory syncytial virus, adenovirus, Sa Keqi, Chinese mugwort can virus, infectious parotitis is viral, prevailing type herpes zoster virus etc., and tangible antiviral and inhibitory action are all arranged.
The curative effect statistics:
Medicament of the present invention attempts treating patient's 82 examples altogether; Medication generally can be seen the improvement effect in 1 course of treatment, can reach curative effect 2 courses of treatment basically, and the number that reaches recovery from illness in 1 course of treatment is 58 people; Take an evident turn for the better in 2 courses of treatment, need continue to take medicine with the number of curing 24 people.
Claims (5)
1. a granule medicament of treating flu is characterized in that, is made up of following materials of weight proportions:
Major ingredient: Radix Bupleuri 30-50 part, Flos Lonicerae 20-40 part, Herba Schizonepetae 10-15 part, Folium Perillae 10-20 part, Folium Isatidis 5-8 part; Pericarpium Citri Reticulatae 6-10 part, Bulbus Fritillariae Cirrhosae 5-8 part, Rhizoma Chuanxiong 5-8 part, Radix Glehniae 10-15 part, Flos Magnoliae 10-15 part; Herba Taraxaci 20-30 part, Radix Puerariae 10-20 part, Semen Coicis 6-15 part, Radix Astragali 5-10 part, Radix Glycyrrhizae 11-18 part; Poria 6-10 part, Radix Ophiopogonis 10-20 part, Rhizoma Et Radix Notopterygii 3-5 part, Flos Chrysanthemi 30-40 part, Fructus Tritici Levis 10-15 part; Semen Nelumbinis 20-30 part, Radix Angelicae Dahuricae 6-10 part, Fructus Mume 10-20 part, Rhizoma Alpiniae Officinarum 8-13 part, stir-fried kidney beans 4-8 part, Bulbus Lilii 3-6 part;
Thickening agent 5-8 part, said thickening agent are any one in starch, maltodextrin, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose, the carboxymethyl starch sodium;
Sweeting agent 3-5 part: said sweeting agent is any one in maltose, mannitol or the xylitol.
2. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 30 parts of Radix Bupleuri, 20 parts of Flos Loniceraes, 10 parts of Herba Schizonepetae, 10 parts of Folium Perillaes, 5 parts of Folium Isatidiss, 6 parts of Pericarpium Citri Reticulataes, 5 parts of Bulbus Fritillariae Cirrhosaes; 5 parts of Rhizoma Chuanxiongs, 10 parts of Radix Glehniaes, 10 parts of Flos Magnoliaes, 20 parts of Herba Taraxacis, 10 parts of Radix Puerariaes, 6 parts of Semen Coicis, 5 parts of the Radixs Astragali; 11 parts in Radix Glycyrrhizae, 6 parts in Poria, 10 parts of Radix Ophiopogonis, 3 parts of Rhizoma Et Radix Notopterygiis, 30 parts of Flos Chrysanthemis, 10 parts of Fructus Tritici Levis; 20 parts of Semen Nelumbinis, 6 parts of the Radixs Angelicae Dahuricae, 10 parts of Fructus Mumes, 8 parts of Rhizoma Alpiniae Officinarums, 4 parts of stir-fried kidney beans, 3 parts of Bulbus Liliies;
5 parts of thickening agents, 3 parts of sweeting agents.
3. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 50 parts of Radix Bupleuri, 40 parts of Flos Loniceraes, 15 parts of Herba Schizonepetae, 20 parts of Folium Perillaes, 8 parts of Folium Isatidiss, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Bulbus Fritillariae Cirrhosaes; 8 parts of Rhizoma Chuanxiongs, 15 parts of Radix Glehniaes, 15 parts of Flos Magnoliaes, 30 parts of Herba Taraxacis, 20 parts of Radix Puerariaes, 15 parts of Semen Coicis, 10 parts of the Radixs Astragali; 18 parts in Radix Glycyrrhizae, 10 parts in Poria, 20 parts of Radix Ophiopogonis, 5 parts of Rhizoma Et Radix Notopterygiis, 40 parts of Flos Chrysanthemis, 15 parts of Fructus Tritici Levis; 30 parts of Semen Nelumbinis, 10 parts of the Radixs Angelicae Dahuricae, 20 parts of Fructus Mumes, 13 parts of Rhizoma Alpiniae Officinarums, 8 parts of stir-fried kidney beans, 6 parts of Bulbus Liliies;
8 parts of thickening agents, 5 parts of sweeting agents.
4. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 44 parts of Radix Bupleuri, 35 parts of Flos Loniceraes, 12 parts of Herba Schizonepetae, 17 parts of Folium Perillaes, 6 parts of Folium Isatidiss, 8 parts of Pericarpium Citri Reticulataes, 7 parts of Bulbus Fritillariae Cirrhosaes; 7 parts of Rhizoma Chuanxiongs, 13 parts of Radix Glehniaes, 12 parts of Flos Magnoliaes, 24 parts of Herba Taraxacis, 16 parts of Radix Puerariaes, 12 parts of Semen Coicis, 8 parts of the Radixs Astragali; 14 parts in Radix Glycyrrhizae, 7 parts in Poria, 13 parts of Radix Ophiopogonis, 4 parts of Rhizoma Et Radix Notopterygiis, 34 parts of Flos Chrysanthemis, 12 parts of Fructus Tritici Levis; 22 parts of Semen Nelumbinis, 8 parts of the Radixs Angelicae Dahuricae, 13 parts of Fructus Mumes, 10 parts of Rhizoma Alpiniae Officinarums, 5 parts of stir-fried kidney beans, 4 parts of Bulbus Liliies;
7 parts of thickening agents, 4 parts of sweeting agents.
5. like any said preparation of medicaments method among the claim 1-4, it is characterized in that, carry out according to following steps:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 60 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the powder about 100 orders, and with various powder even blend;
(4) pour in the electric-heating container powder after the mixing of step (3) gained or Steam Heating, the decocting that dosing grain weight amount is 10 times boiled 4 hours, and temperature is no more than 100 ℃, filtered medicinal residues, collected the gained medicinal liquid;
(5) water that step (4) gained medicinal residues is added 5 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(6) with twice collected combining medicine that gets, centrifugalize concentrates after removing remaining tiny medicinal residues; 80 ℃ of thickening temperatures, 1 hour time;
(7) thickening agent and the sweeting agent in the adding formula proportion fully stirs, and makes it reach concentration about 80%;
(8) spray drying forming;
(9) granulate, sieve, packing, sterilization, quality inspection, packing, obtain the finished particle agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210013656 CN102526578B (en) | 2012-01-17 | 2012-01-17 | Granular medicine for treating cold |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210013656 CN102526578B (en) | 2012-01-17 | 2012-01-17 | Granular medicine for treating cold |
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| CN102526578A true CN102526578A (en) | 2012-07-04 |
| CN102526578B CN102526578B (en) | 2013-08-14 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836203A (en) * | 2012-09-18 | 2012-12-26 | 南京正亮医药科技有限公司 | Traditional Chinese medicine composition for treating wind-heat type common cold as well as preparation method and application thereof |
| CN103815094A (en) * | 2013-12-14 | 2014-05-28 | 潘清水 | Health protection tea |
| CN105560500A (en) * | 2014-10-14 | 2016-05-11 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for treatment of influenza |
| CN106377741A (en) * | 2016-09-27 | 2017-02-08 | 魏庆 | Traditional Chinese medicine for treating infertility and preparation method thereof |
| CN107307142A (en) * | 2017-06-28 | 2017-11-03 | 邢夺伟 | A kind of golden aster tea for preventing and treating influenza |
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| CN1161840A (en) * | 1996-03-19 | 1997-10-15 | 路晓康 | Medicine for making four-seasons tea for treating cold and preparation technology thereof |
| CN101524524A (en) * | 2009-04-23 | 2009-09-09 | 彭海清 | Drug for treating severe cold and preparation method thereof |
| CN102048973A (en) * | 2010-10-28 | 2011-05-11 | 闫吉强 | Medicament for treating cold |
| CN102145114A (en) * | 2011-03-29 | 2011-08-10 | 权士珍 | Novel traditional Chinese medicine for treating cold |
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2012
- 2012-01-17 CN CN 201210013656 patent/CN102526578B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093581A (en) * | 1993-04-16 | 1994-10-19 | 刘永举 | The compound method of tea capable of preventing and curing cold |
| CN1161840A (en) * | 1996-03-19 | 1997-10-15 | 路晓康 | Medicine for making four-seasons tea for treating cold and preparation technology thereof |
| CN101524524A (en) * | 2009-04-23 | 2009-09-09 | 彭海清 | Drug for treating severe cold and preparation method thereof |
| CN102048973A (en) * | 2010-10-28 | 2011-05-11 | 闫吉强 | Medicament for treating cold |
| CN102145114A (en) * | 2011-03-29 | 2011-08-10 | 权士珍 | Novel traditional Chinese medicine for treating cold |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102836203A (en) * | 2012-09-18 | 2012-12-26 | 南京正亮医药科技有限公司 | Traditional Chinese medicine composition for treating wind-heat type common cold as well as preparation method and application thereof |
| CN103815094A (en) * | 2013-12-14 | 2014-05-28 | 潘清水 | Health protection tea |
| CN105560500A (en) * | 2014-10-14 | 2016-05-11 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for treatment of influenza |
| CN106377741A (en) * | 2016-09-27 | 2017-02-08 | 魏庆 | Traditional Chinese medicine for treating infertility and preparation method thereof |
| CN107307142A (en) * | 2017-06-28 | 2017-11-03 | 邢夺伟 | A kind of golden aster tea for preventing and treating influenza |
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| Publication number | Publication date |
|---|---|
| CN102526578B (en) | 2013-08-14 |
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