CN107929593B - Medicament for treating children cough - Google Patents

Medicament for treating children cough Download PDF

Info

Publication number
CN107929593B
CN107929593B CN201711361317.8A CN201711361317A CN107929593B CN 107929593 B CN107929593 B CN 107929593B CN 201711361317 A CN201711361317 A CN 201711361317A CN 107929593 B CN107929593 B CN 107929593B
Authority
CN
China
Prior art keywords
percent
cough
medicament
root
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201711361317.8A
Other languages
Chinese (zh)
Other versions
CN107929593A (en
Inventor
帅云飞
李鑫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201711361317.8A priority Critical patent/CN107929593B/en
Publication of CN107929593A publication Critical patent/CN107929593A/en
Application granted granted Critical
Publication of CN107929593B publication Critical patent/CN107929593B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicament for treating children cough, which comprises the following components: raw ephedra, perilla leaves, platycodon grandiflorum, codonopsis pilosula, astragalus mongholicus, trichosanthes kirilowii maxim, rhizoma phragmitis, mangnolia officinalis, pericarpium citri reticulatae and agastache rugosus; the preparation method comprises mixing the raw materials, soaking in water in casserole, boiling with strong fire, decocting with slow fire, and filtering to obtain filtrate. The invention scientifically mixes the raw materials of the medicine aiming at children of different ages, can be used for treating cough of 0-18 years old children such as acute bronchitis, asthmatic bronchitis, capillary bronchitis, cough variant asthma (allergic cough), bronchial asthma, bronchopneumonia and the like, has obvious curative effect on treating cough and repeated cough, and has the effective rate of more than 98 percent.

Description

Medicament for treating children cough
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicament for treating children cough.
Background
Children are easily affected by environmental changes, and have weak resistance to the external environment; if the nursing is not thorough, the disease symptoms such as cold, cough or fever of children can be easily caused. Cough in children is a common disease, and particularly, the cough which is easy to cause lung discomfort due to cold is very easy to relapse. As the viscera of children are crisp and tender, the adaptability to the change of weather is low, and the cough is easily caused by the direct influence of the change of weather. The early stage of the disease is accompanied by chills and fever, no sweat, headache, nasal obstruction and watery nasal discharge, and the cough is accompanied by thin and white sputum, thin and white tongue coating and floating pulse.
At present, the common medicines for treating children cough are mainly western medicines, such as: antibiotics and antitussives, which have serious side effects and are liable to cause damage to the growth and development of children. In addition, the traditional Chinese medicines sold in the market have low side effect, but have slow curative effect and bitter taste, and children resist taking the medicines, are not beneficial to treatment and are easy to cause the pulmonary infection of the children.
Chinese patent application No. 201610148528.2 discloses a Chinese medicinal composition for treating children cough, which comprises the following components: 2-5 parts of radix ophiopogonis, 1-2 parts of cistanche, 4-8 parts of honeysuckle, 4-6 parts of hairyvein agrimony, 2-3 parts of polygonum perfoliatum, 2-3 parts of tree peony bark, 4-8 parts of loquat leaf, 1-3 parts of celery, 1-3 parts of abrus cantoniensis hance, 1-2 parts of grifola, 1-2 parts of forgetfulness, 1-3 parts of borneol, 5-6 parts of radix bupleuri, 2-3 parts of rhizoma arisaematis and 3-4 parts of rice sprout.
Chinese patent application No. 201210412132.6 discloses a traditional Chinese medicine for treating children cough, which is prepared from the following raw materials in parts by weight: 3-9 parts of radix asparagi, 3-9 parts of radix scrophulariae, 3-12 parts of poria cocos, 3-9 parts of radix ophiopogonis, 3-6 parts of fritillaria cirrhosa, 3-9 parts of perilla leaves, 3-6 parts of liquorice, 3-9 parts of scutellaria baicalensis, 3-9 parts of flos farfarae, 3-9 parts of wild buckwheat rhizome, 3-9 parts of selfheal spike, 3-9 parts of citron and 3-9 parts of fructus aristolochiae.
The traditional Chinese medicine for treating children cough achieves a certain treatment effect, some of the traditional Chinese medicines are still in experiments, but the raw materials of the traditional Chinese medicines are not scientifically proportioned aiming at children of different ages, the children of different ages are distinguished mainly by controlling the taking amount when the traditional Chinese medicines are taken, the traditional Chinese medicines are easy to grasp inaccurately, and the treatment effect cannot be achieved or side effects are caused.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a medicament for treating children cough.
The invention provides a medicament for treating children cough, which comprises the following components in percentage by weight: 2.32 to 3.70 percent of raw ephedra herb, 6.97 to 11.63 percent of perilla leaf, 3.70 to 5.81 percent of balloonflower root, 13.95 to 18.61 percent of radix codonopsitis, 16.13 to 18.61 percent of astragalus root, 16.13 to 18.61 percent of trichosanthes root, 16.13 to 18.61 percent of reed rhizome, 2.32 to 5.83 percent of officinal magnolia bark, 3.49 to 5.38 percent of tangerine peel and 3.70 to 5.82 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 2.32 percent of raw ephedra herb, 6.97 percent of perilla leaf, 4.65 percent of balloonflower root, 18.61 percent of radix codonopsitis, 18.61 percent of astragalus root, 18.61 percent of trichosanthes root, 18.61 percent of reed rhizome, 2.32 percent of magnolia bark, 4.65 percent of tangerine peel and 4.65 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 3.70 percent of raw ephedra herb, 7.41 percent of perilla leaf, 3.70 percent of balloonflower root, 18.53 percent of radix codonopsitis, 18.52 percent of astragalus root, 18.52 percent of trichosanthes root, 18.52 percent of reed rhizome, 3.70 percent of magnolia bark, 3.70 percent of dried orange peel and 3.70 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 3.03 percent of raw ephedra herb, 9.08 percent of perilla leaf, 4.55 percent of balloonflower root, 15.15 percent of radix codonopsitis, 18.18 percent of astragalus root, 18.18 percent of trichosanthes root, 18.18 percent of reed rhizome, 4.55 percent of magnolia bark, 4.55 percent of dried orange peel and 4.55 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 2.63 percent of raw ephedra herb, 10.53 percent of perilla leaf, 5.26 percent of platycodon root, 15.79 percent of radix codonopsitis, 15.79 percent of astragalus root, 18.42 percent of trichosanthes root, 18.42 percent of reed, 3.95 percent of magnolia bark, 3.95 percent of dried orange peel and 5.26 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 3.49 percent of raw ephedra herb, 11.63 percent of perilla leaf, 5.81 percent of balloonflower root, 13.95 percent of radix codonopsitis, 17.44 percent of astragalus root, 17.44 percent of trichosanthes root, 17.44 percent of reed rhizome, 3.49 percent of magnolia bark, 3.49 percent of dried orange peel and 5.82 percent of wrinkled gianthyssop herb.
Preferably, the medicament for treating children cough comprises the following components in percentage by weight: 3.22 percent of raw ephedra herb, 10.74 percent of perilla leaf, 5.38 percent of platycodon root, 16.13 percent of radix codonopsitis, 16.13 percent of astragalus root, 16.13 percent of trichosanthes root, 16.13 percent of reed rhizome, 5.38 percent of magnolia bark, 5.38 percent of dried orange peel and 5.38 percent of wrinkled gianthyssop herb.
Preferably, the preparation method of the medicament for treating children cough comprises the following steps: mixing the traditional Chinese medicine raw materials according to the proportion of 2.32-3.70% of raw ephedra herb, 6.97-11.63% of perilla leaf, 3.70-5.81% of balloonflower root, 13.95-18.61% of radix codonopsitis, 16.13-18.61% of astragalus root, 16.13-18.61% of trichosanthes root, 16.13-18.61% of reed rhizome, 2.32-5.83% of magnolia officinalis, 3.49-5.38% of dried orange peel and 3.70-5.82% of wrinkled gianthyssop herb uniformly, placing the mixture in an earthen pot, adding water for soaking, wherein the volume mass ratio of the water to the traditional Chinese medicine raw materials is 4.5: 1g, boiling with strong fire, then decocting with slow fire, and filtering to obtain filtrate, namely the medicament for treating children cough.
The invention has the beneficial effects that: the invention inherits the concept of 'no cough and cough stopping', adopts the functions of dispersing lung qi, conditioning middle-jiao qi and circulating qi of the whole body, has obvious effect and really reflects 'treating diseases and seeking the basis'. The invention scientifically mixes the raw materials of the medicine aiming at children of different ages, can be used for treating cough of 0-18 years old children such as acute bronchitis, asthmatic bronchitis, capillary bronchitis, cough variant asthma (allergic cough), bronchial asthma, bronchopneumonia and the like, has obvious curative effect on treating cough and repeated cough, and has the effective rate of more than 98 percent.
Cough and repeated cough are common diseases and frequently encountered diseases of children. Cough is a protective reflex, i.e. rejection, of the human body and should not be "coughing" therapeutically. According to the syndrome of "liver is always abundant, spleen is always deficient, heart is always abundant, lung is always deficient, kidney is always deficient" and "qi is always deficient" of pathogens ". The children have weak three zang organs and strong two zang organs, and pathogenic qi usually enters from the weak three zang organs. The lung governs exterior, the exterior is susceptible to external infection, the spleen is weak, and the patient is susceptible to food damage. Exogenous pathogenic factors and food injury usually occur simultaneously or affect each other the second time, i.e., exogenous pathogenic factors cause food injury, which causes exogenous pathogenic factors, and they are related to the connection of mother and child qi. Clinically, the three kinds of deficiency should be distinguished according to the characteristics of the liver and heart, and whether there is heart-liver yang-qi stagnation should be distinguished according to the characteristics of the liver and heart, and if there is no obvious fire-heat image, it is impossible for ten thousand to treat the yang-heat with bitter cold, and the generated qi should be removed and not killed. The rule of Huangdi's classic on questions and cough treatises on lung and spleen is as follows: in case of fur, the lung is combined, and the fur is affected by pathogenic qi first and then combined. When cold fluid enters the stomach, it enters the lung from the lung pulse, resulting in lung cold, which is combined with pathogenic factors from the exterior to the interior, and cough in the lung. Cough and repeated cough cause both exogenous pathogens and food injury, and cause deficiency to excess and deficiency to excess, and are treated by complementary purgative methods, i.e., tonifying lung and spleen and tonifying spleen and lung. When tonifying lung, there is a way for phlegm to flow out, and when there is a way for phlegm to flow out, spleen dampness is removed; the spleen tonifies phlegm-dampness, while the lung excess (phlegm) is discharged.
Raw ephedra: the lung meridian entered, the detection that the crude drug contains the effective components of ephedrine, methyllevoephedrine, pseudoheteroephedrine A and B, etc., so the medicine has good effects of relieving cough and asthma, increasing sweat gland secretion, and has the functions of sweating, dispelling cold evil and relieving fever.
And (3) perilla leaves: it enters spleen channel and lung channel, and is used for treating common cold, wind-cold, fever, aversion to cold, headache, nasal obstruction, cough or chest distress, and can disperse exterior cold and disperse lung qi.
Balloon flower: enter lung meridian, open lung qi, dispel phlegm and expel pus. It is indicated for cough due to exogenous pathogenic factors, swollen and sore throat, lung abscess with pus, fullness in chest, hypochondriac pain, dysentery and abdominal pain.
Codonopsis pilosula: entering spleen meridian, it can treat spleen deficiency, anorexia, loose stool, cough and asthma due to qi deficiency, strengthen the middle-jiao, replenish qi, harmonize stomach, promote fluid production, dispel phlegm, and relieve cough.
Astragalus root: enters spleen meridian and has the functions of invigorating spleen and strengthening stomach.
Trichosanthes root: the specific effects of the heat-clearing and fire-purging herbs which enter lung and stomach channels and clear heat and purge fire, promote the production of body fluid to quench thirst, expel pus and relieve swelling.
Reed rhizome: enters lung channel and stomach channel, and has the effects of clearing heat, promoting fluid production, relieving restlessness, arresting vomiting and promoting urination.
Magnolia officinalis: entering spleen, stomach and large intestine meridians, has the effects of promoting qi circulation, removing food stagnation, eliminating dampness, relieving fullness, lowering adverse qi and relieving asthma.
Dried orange peel: the Chinese medicinal composition enters lung channel, spleen channel and stomach channel, is suitable for symptoms such as weakness of spleen and stomach, diet reduction, dyspepsia, excrement diarrhea and the like, and can strengthen spleen and regulate qi.
Agastache rugosus: it is used for treating early stage of damp-warm syndrome, fever, listlessness, chest distress, cold-dampness, summer-heat, and lung deficiency with cold syndrome.
The medicines are researched and selected to enter lung channels or spleen channels, so that the traditional Chinese medicine composition can well protect spleen and lung, promote lung qi to be smooth, regulate middle-jiao energy, and circulate qi of the whole body, and has the strong effects of treating cough, reducing phlegm, relieving asthma, clearing and moistening throat and trachea, eliminating sore throat, relieving fever, sweating, dispelling cold evil and the like.
Detailed Description
Example 1
A medicament for treating children cough comprises the following components in parts by weight: 1g of raw ephedra herb, 3g of perilla leaf, 2g of platycodon root, 8g of codonopsis pilosula, 8g of astragalus, 8g of trichosanthes root, 8g of reed rhizome, 1g of magnolia bark, 2g of dried orange peel and 2g of wrinkled gianthyssop herb. The specific use method comprises the following steps: mixing the above materials uniformly, placing in casserole, soaking in 200ml water for 20min, boiling with strong fire, decocting with slow fire for 10-15min, and filtering to obtain 50-100ml medicinal liquid for twice a day. The preparation is suitable for children patients of 0-1 year old.
Example 2
A medicament for treating children cough comprises the following components in parts by weight: 2g of raw ephedra herb, 4g of perilla leaf, 2g of platycodon root, 10g of codonopsis pilosula, 10g of astragalus root, 10g of trichosanthes root, 10g of reed rhizome, 2g of magnolia bark, 2g of dried orange peel and 2g of wrinkled gianthyssop herb. The specific use method comprises the following steps: the traditional Chinese medicine raw materials are uniformly mixed according to the weight parts, placed in an earthen pot, soaked in 300mL of water for 20min, boiled on fire with strong fire, then decocted on slow fire for 10-15min, filtered to obtain 100mL and 150mL of liquid medicine, and taken twice a day. The preparation is suitable for children of 1-3 years old.
Example 3
A medicament for treating children cough comprises the following components in parts by weight: 2g of raw ephedra herb, 6g of perilla leaf, 3g of platycodon root, 10g of codonopsis pilosula, 12g of astragalus root, 12g of trichosanthes root, 12g of reed rhizome, 3g of magnolia bark, 3g of dried orange peel and 3g of wrinkled gianthyssop herb. The specific use method comprises the following steps: the traditional Chinese medicine raw materials are uniformly mixed according to the weight parts, placed in an earthen pot, soaked in 300mL of water for 20min, boiled on fire with strong fire, then decocted on slow fire for 10-15min, filtered to obtain 100mL and 150mL of liquid medicine, and taken twice a day. The preparation is suitable for children patients of 3-6 years old.
Example 4
A medicament for treating children cough comprises the following components in parts by weight: 2g of raw ephedra herb, 8g of perilla leaf, 4g of platycodon root, 12g of codonopsis pilosula, 12g of astragalus root, 14g of trichosanthes root, 14g of reed rhizome, 3g of magnolia bark, 3g of dried orange peel and 4g of wrinkled gianthyssop herb. The specific use method comprises the following steps: the traditional Chinese medicine raw materials are uniformly mixed according to the parts by weight, placed in an earthenware pot, soaked in 400mL of water for 20min, boiled on fire with strong fire, then decocted on slow fire for 10-15min, and filtered to obtain 100mL and 200mL of liquid medicine, which are taken twice a day. The preparation is suitable for children of 6-10 years old.
Example 5
A medicament for treating children cough comprises the following components in parts by weight: 3g of raw ephedra herb, 10g of perilla leaf, 5g of platycodon root, 12g of codonopsis pilosula, 15g of astragalus root, 15g of trichosanthes root, 15g of reed rhizome, 3g of magnolia bark, 3g of dried orange peel and 5g of wrinkled gianthyssop herb. The specific use method comprises the following steps: the traditional Chinese medicine raw materials are uniformly mixed according to the parts by weight, placed in an earthenware pot, soaked in 500mL of water for 20min, boiled on fire with strong fire, then decocted on slow fire for 10-15min, and filtered to obtain 150mL of liquid medicine, and the liquid medicine is taken twice a day. The preparation is suitable for children 10-14 years old.
Example 6
A medicament for treating children cough comprises the following components in parts by weight: 3g of raw ephedra herb, 10g of perilla leaf, 5g of platycodon root, 15g of codonopsis pilosula, 15g of astragalus root, 15g of trichosanthes root, 15g of reed rhizome, 5g of magnolia bark, 5g of dried orange peel and 5g of wrinkled gianthyssop herb. The specific use method comprises the following steps: the traditional Chinese medicine raw materials are uniformly mixed according to the parts by weight, placed in an earthen pot, soaked in 600mL of water for 20min, boiled on fire with strong fire, then decocted on slow fire for 10-15min, and filtered to obtain 200mL and 250mL of liquid medicine, which are taken twice a day. The preparation is suitable for 14-18 years old children patients.
Comparative example 1
Commercially available Bulbus Fritillariae Cirrhosae cough syrup (Chinese medicine standard character Z22020176) for children is prepared from herba Chelidonii, fructus Trichosanthis, rhizoma Pinelliae (processed with Alumen), and Bulbus Fritillariae Ussuriensis.
Cough relieving experiment of drug of the invention on rats with cough induced by strong ammonia water
100 healthy SD rats with half male and half female body weight of 20-200g are divided into 10 groups according to body weight, each group comprises 10 rats, wherein 20-40g of 10 mice in each half of male and female are used for treating group A, 40-60g of 10 mice in each half of female and male are used for treating group B, 60-90g of 10 mice in each half of male and female are used for treating group C, 90-120g of 10 mice in each half of male and female are used for treating group D, 120-160g of 10 mice in each half of male and female are used for treating group E, 160-200g of 10 mice in each half of male and female are used for treating group F, 20-40g of 10 mice in each half of male and female are used for treating group A, 60-90g of 10 mice in each half of male and female are used for treating group C, 90-120g of 10 mice in each half of male and female are used for treating group D, and 60-90g of 10 mice in each half of male and female are used for treating blank group. Then, corresponding medicines are administered by intragastric administration, 5ml of distilled water is intragastric administered to a distilled water group, the medicine of the group A intragastric administration example 1 is treated, the medicine of the group B intragastric administration example 2 is treated, the medicine of the group C intragastric administration example 3 is treated, the medicine of the group D intragastric administration example 4 is treated, the medicine of the group E intragastric administration example 5 is treated, the medicine of the group F intragastric administration example 6 is treated, the syrup of the group A, C, D intragastric administration example 1 is contrasted, the specific dosage is shown in the table 1, 1 time per day, 7 days of continuous administration is carried out, after 1 hour of the last administration, a rat is placed in a constant pressure spraying device, concentrated ammonia water is sprayed at constant speed in an isobaric manner, the contraction and opening of abdominal muscles of the rat are taken as cough action indications, the incubation period from the beginning of spraying until two minutes of cough of the rat occurs is observed, and the. The results are shown in Table 1.
TABLE 1 Effect of the agents of the present invention on Ammonia-induced cough in rats
Group of Dosage (ml) Cough incubation(s) Number of coughs within two minutes
Distilled water set 5 40.56±6.76 28.42±4.31
Treatment of group A 1.6 74.69±3.77*## 15.65±4.12*##
Treatment of group B 3.2 71.07±5.23* 14.78±3.56*
Treatment of group C 4.8 76.33±5.78**## 16.34±4.70**##
Treatment of group D 8 69.45±3.90*## 16.11±5.22*##
Treatment of group E 9.6 74.99±6.12* 13.07±5.95*
Treatment of group F 8 67.65±4.61* 14.46±4.40*
Control group A 0.3 56.77±5.43* 20.61±3.38*
Control group C 1.1 62.65±3.78** 19.78±3.96**
Control group D 1.6 54.32±4.60* 25.32±4.66*
Note: p <0.05, P <0.01 compared to distilled water group; compared with the control group, # P <0.05, # P < 0.01.
As can be seen from table 1, the treatment group had a significantly longer cough latency and a significantly smaller number of coughs within two minutes compared to the model group, and had a significantly different value, and the control group had a significantly different cough latency and a significantly different number of coughs within two minutes compared to the distilled water group (P < 0.01). Compared with a control group, the treatment A group, the treatment C group and the treatment D group of the traditional Chinese medicine composition have very obvious difference (P is less than 0.01), and the traditional Chinese medicine composition has obvious cough relieving effect on rats with cough caused by strong ammonia water.
Phenol red phlegm eliminating experiment of medicament on SD rat
100 healthy SD rats with half male and half female body weight of 20-200g are divided into 10 groups according to body weight, each group comprises 10 rats, wherein 20-40g of 10 mice in each half of male and female are used for treating group A, 40-60g of 10 mice in each half of female and male are used for treating group B, 60-90g of 10 mice in each half of male and female are used for treating group C, 90-120g of 10 mice in each half of male and female are used for treating group D, 120-160g of 10 mice in each half of male and female are used for treating group E, 160-200g of 10 mice in each half of male and female are used for treating group F, 20-40g of 10 mice in each half of male and female are used for treating group A, 60-90g of 10 mice in each half of male and female are used for treating group C, 90-120g of 10 mice in each half of male and female are used for treating group D, and 60-90g of 10 mice in each half of male and female are used for treating blank group. Then, the corresponding drugs are administered by gavage, 5ml of distilled water is used for gavage in a distilled water group, the drugs of the gavage example 1 in the treatment group A, the drugs of the gavage example 2 in the treatment group B, the drugs of the gavage example 3 in the treatment group C, the drugs of the gavage example 4 in the treatment group D, the drugs of the gavage example 5 in the treatment group E and the drugs of the gavage example 6 in the treatment group F are compared with A, C, D syrup in the gavage comparative example 1 in the treatment group C, the specific dose is as shown in the table 2, 1 time per day is continuously administered for 7 days, after 30min of last administration, 0.5ml of phenol red solution is injected into the abdominal cavity of the rat, after 30min of injection, the rat is killed, tissues around the trachea are stripped, a section of trachea from the lower part of the thyroid cartilage to the branch of the trachea is cut off, a test tube containing physiological saline is placed, 1mol/L of sodium hydroxide solution is added into each sample, the absorbance value is measured at a wavelength of 546nm, and the absorbance is converted into the phenol red content according to the phenol red standard curve. The results are shown in Table 2.
TABLE 2 Effect of the Agents of the present invention on the amount of phenol Red excretion
Group of Dosage of medicament (ml) Phenol Red solution concentration (%) Phenol Red concentration (μ g/ml)
Distilled water set 5 3 0.072±0.013
Treatment of group A 1.6 2.5 0.071±0.012*##
Treatment of group B 3.2 2.8 0.086±0.013*
Treatment of group C 4.8 3 0.087±0.011**##
Treatment of group D 8 3.2 0.090±0.012*##
Treatment of group E 9.6 3.5 0.098±0.012*
Treatment of group F 8 4 0.120±0.013*
Control group A 0.3 2.5 0.069±0.011*
Control group C 1.1 3 0.081±0.012**
Control group D 1.6 3.2 0.086±0.011*
Note: p <0.05, P <0.01 compared to distilled water group; compared with the control group, # P <0.05, # P < 0.01.
The standard curve of phenol red is 0.12577x +0.0313(y is phenol red concentration, x is absorbance, and gamma is 0.997), and the increase of the excretion amount of phenol red means that the sputum excretion capacity of the mouse is enhanced. As can be seen from table 2, the concentration of phenol red was significantly different (P <0.01) in the treatment group C compared to the distilled water group, and significantly different (P <0.01) in the control group C compared to the distilled water group. Compared with a control group, the treatment A group, the treatment C group and the treatment D group of the traditional Chinese medicine composition have obvious difference (P is less than 0.01), and the traditional Chinese medicine composition has obvious improvement effect on the excretion of phenol red of rats.

Claims (8)

1. The medicament for treating children cough is characterized in that the Chinese medicinal raw materials of the medicament comprise the following components in percentage by weight: 2.32 to 3.70 percent of raw ephedra herb, 6.97 to 11.63 percent of perilla leaf, 3.70 to 5.81 percent of balloonflower root, 13.95 to 18.61 percent of radix codonopsitis, 16.13 to 18.61 percent of astragalus root, 16.13 to 18.61 percent of trichosanthes root, 16.13 to 18.61 percent of reed rhizome, 2.32 to 5.83 percent of magnolia officinalis, 3.49 to 5.38 percent of dried orange peel and 3.70 to 5.82 percent of wrinkled gianthyssop herb; the cough of children is caused by acute bronchitis, asthmatic bronchitis, bronchiolitis, cough variant asthma, bronchial asthma and bronchopneumonia of children.
2. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 2.32 percent of raw ephedra herb, 6.97 percent of perilla leaf, 4.65 percent of balloonflower root, 18.61 percent of radix codonopsitis, 18.61 percent of astragalus root, 18.61 percent of trichosanthes root, 18.61 percent of reed rhizome, 2.32 percent of magnolia bark, 4.65 percent of tangerine peel and 4.65 percent of wrinkled gianthyssop herb.
3. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 3.70 percent of raw ephedra herb, 7.41 percent of perilla leaf, 3.70 percent of balloonflower root, 18.53 percent of radix codonopsitis, 18.52 percent of astragalus root, 18.52 percent of trichosanthes root, 18.52 percent of reed rhizome, 3.70 percent of magnolia bark, 3.70 percent of dried orange peel and 3.70 percent of wrinkled gianthyssop herb.
4. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 3.03 percent of raw ephedra herb, 9.08 percent of perilla leaf, 4.55 percent of balloonflower root, 15.15 percent of radix codonopsitis, 18.18 percent of astragalus root, 18.18 percent of trichosanthes root, 18.18 percent of reed rhizome, 4.55 percent of magnolia bark, 4.55 percent of dried orange peel and 4.55 percent of wrinkled gianthyssop herb.
5. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 2.63 percent of raw ephedra herb, 10.53 percent of perilla leaf, 5.26 percent of platycodon root, 15.79 percent of radix codonopsitis, 15.79 percent of astragalus root, 18.42 percent of trichosanthes root, 18.42 percent of reed, 3.95 percent of magnolia bark, 3.95 percent of dried orange peel and 5.26 percent of wrinkled gianthyssop herb.
6. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 3.49 percent of raw ephedra herb, 11.63 percent of perilla leaf, 5.81 percent of balloonflower root, 13.95 percent of radix codonopsitis, 17.44 percent of astragalus root, 17.44 percent of trichosanthes root, 17.44 percent of reed rhizome, 3.49 percent of magnolia bark, 3.49 percent of dried orange peel and 5.82 percent of wrinkled gianthyssop herb.
7. The medicament for treating children cough according to claim 1, wherein the traditional Chinese medicine raw materials of the medicament comprise the following components in percentage by weight: 3.22 percent of raw ephedra herb, 10.74 percent of perilla leaf, 5.38 percent of platycodon root, 16.13 percent of radix codonopsitis, 16.13 percent of astragalus root, 16.13 percent of trichosanthes root, 16.13 percent of reed rhizome, 5.38 percent of magnolia bark, 5.38 percent of dried orange peel and 5.38 percent of wrinkled gianthyssop herb.
8. The method for preparing a medicament for treating cough in children according to any one of claims 1 to 7, comprising the steps of: uniformly mixing the traditional Chinese medicine raw materials according to the components and the weight ratio defined in any one of claims 1 to 7, placing the mixture in a marmite, and soaking the mixture in water, wherein the volume mass ratio of the water to the traditional Chinese medicine raw materials is 4.5-6.5 ml: 1g, boiling with strong fire, then decocting with slow fire, and filtering to obtain filtrate, namely the medicament for treating children cough.
CN201711361317.8A 2017-12-18 2017-12-18 Medicament for treating children cough Active CN107929593B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711361317.8A CN107929593B (en) 2017-12-18 2017-12-18 Medicament for treating children cough

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711361317.8A CN107929593B (en) 2017-12-18 2017-12-18 Medicament for treating children cough

Publications (2)

Publication Number Publication Date
CN107929593A CN107929593A (en) 2018-04-20
CN107929593B true CN107929593B (en) 2021-05-11

Family

ID=61944543

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711361317.8A Active CN107929593B (en) 2017-12-18 2017-12-18 Medicament for treating children cough

Country Status (1)

Country Link
CN (1) CN107929593B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101152530A (en) * 2007-09-19 2008-04-02 牛海艳 Method for preparing defervesce and promoting digestion capsule for children
CN106266851A (en) * 2015-06-02 2017-01-04 北京海吉星医疗科技有限公司 A kind of chewable tablet of Chinese medicine composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101152530A (en) * 2007-09-19 2008-04-02 牛海艳 Method for preparing defervesce and promoting digestion capsule for children
CN106266851A (en) * 2015-06-02 2017-01-04 北京海吉星医疗科技有限公司 A kind of chewable tablet of Chinese medicine composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中西医结合治疗小儿支原体肺炎32例疗效观察;王翠玲等;《河南中医》;20090131(第01期);74,75 *
宣肺祛湿化痰汤治疗风寒咳嗽;何大昌;《四川中医》;20080515(第05期);60 *

Also Published As

Publication number Publication date
CN107929593A (en) 2018-04-20

Similar Documents

Publication Publication Date Title
CN101342317B (en) Medicament composition for treating tuberculosis and preparation method thereof
CN102846866B (en) Chinese medicine composition for prevention and control of porcine circovirus disease and preparation method thereof
CN103920106A (en) Traditional Chinese medicinal composition for treating bronchitis and bronchial asthma
CN104857238A (en) Traditional Chinese medicine for treating spleen-kidney-yang deficiency type iron-deficiency anemia and preparation method
CN107929593B (en) Medicament for treating children cough
CN108771754A (en) A kind of Chinese medicine composition and preparation method thereof for treating laying hen middle and later periods salpingitis
CN104027540A (en) Traditional Chinese medicine for treating asthma caused by syndrome of phlegm and blood stasis obstructing lung
CN103989762B (en) Chinese medicine composition of internal organs relieving cough and resolving phlegm and preparation method thereof is rushed down in a kind of heat clearing away
CN105250968A (en) Traditional Chinese medicine preparation for treating asthma
CN104606600A (en) Traditional Chinese medicine composition for treating interstitial lung disease and preparation method of composition
CN104998005A (en) Traditional Chinese medicine oral liquid special for treating constipation and preparation method thereof
CN104491318A (en) Traditional Chinese preparation used for treating asthma and preparation method of traditional Chinese preparation
CN104547859A (en) Application of traditional Chinese medicine preparation in preparation of medicine for treating chronic tracheitis
CN101985020B (en) Chinese medicament for treating tracheitis
CN108144037B (en) Traditional Chinese medicine composition for treating cough and application thereof
CN105012761A (en) Traditional Chinese medicine composition for treating urinary tract infection
CN105901199A (en) Heat-clearing herbal tea and production method thereof
CN105770779A (en) Medicine composition for preventing and treating contagious bovine pleuropneumonia and preparation method thereof
CN105412679A (en) Traditional Chinese medicine preparation for treating lung abscess and preparation method thereof
CN106806762A (en) A kind of Chinese medicine preparation for treating many phlegm bronchiectasis and preparation method thereof
CN105267687A (en) Traditional Chinese medicine preparation for treating acute tonsillitis and preparation method thereof
CN105106775A (en) Traditional Chinese medicine preparation for treating puerperal constipation and preparation method thereof
CN104689051A (en) Traditional Chinese medicine formula of phlegm eliminating drug and preparation method thereof
CN104623203A (en) Traditional-Chinese-medicine composition for treating blood-deficiency and wind-dryness type eczema
CN104547865A (en) Application of traditional Chinese medicine preparation in preparing medicine for treating senile dementia

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant