CN104606627A - Pharmaceutical composition treating pigling diarrhoea and preparation method thereof - Google Patents
Pharmaceutical composition treating pigling diarrhoea and preparation method thereof Download PDFInfo
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Abstract
A provided pharmaceutical composition treating pigling diarrhea comprises: a first gavaging medicine and a second gavaging medicine, wherein the first gavaging medicine comprises, in parts by weight, 50-70 parts of herba potentillae chinensis, 50-70 parts of shrubalthea flower, 40-60 parts of red-knees herb, 40-60 parts of radix pulsatillae, 40-60 parts of cortex fraxini, 20-40 parts of purslane, 10-30 parts of radix curcumae, 10-30 parts of rhizoma atractylodis; and the second gavaging medicine comprises, in parts by weight, 3-7 parts of montmorillonite powder, and 3-7 parts of a bacteria-growth promoting tablet. The first gavaging medicine is taken at morning, the second gavaging medicine is taken at afternoon, and the two medicines are taken at certain intervals. The above medicines are organically combined, and through syndrome-differentiation compatibility and mutual complementation, the pharmaceutical composition is enhanced in efficacy of clearing heat, drying dampness and checking diarrhea, thereby realizing the purpose of curing pigling diarrhea, and the cure rate is 92.17% and the effective rate is 99.40%. The pharmaceutical composition prepared by the preparation method is relatively obvious in effect.
Description
Technical field
The present invention relates to the pharmaceutical composition for the treatment of Animal diseases, particularly a kind of pharmaceutical composition for the treatment of piglet diarrhea and preparation method thereof.
Background technology
Piglet diarrhea clinically sickness rate, mortality rate is all higher, is the disease of a class serious harm pig industry development.Very general at China's primary disease, it is reported, the piglet of below 30kg, average of the whole year sickness rate 46.5%, mortality rate reaches 15%, every year to the more than one hundred million unit of direct economic loss that industrial belt of raising pigs is come.Primary disease is also higher at the M & M of the countries such as the more flourishing America and Europe of pig industry, and primary disease all brings great puzzlement to poultry feeders, especially Compact Develop both at home and abroad.Piglet, once suffer from diarrhoea, except making medication expense and rising, also causes that the survival rate of piglet declines, poor growth or stagnation, thus affects the price of deed, reduction fertility performance, causes huge economic loss to pig farm.Cause the cause of disease of morbidity of a great variety, characteristic of disease is complicated, wherein has virus (transmissible gastroenteritis, epidemic diarrhea, rotavirus etc.), antibacterial (escherichia coli, clostridieum welchii, Salmonella, vibrio etc.), parasite (coccidiosis, pouch ciliate etc.).According to the emergency of morbidity, show different symptoms.Large frequently-occurring disease is anxious, body temperature raises, be afraid of cold, like and bore careless nest or crowdedly to flock together, and spirit is depressed, big-eared ear of bowing, be reluctant activity, loss of appetite or do not eat, dyspnea, water sample is had loose bowels, feces is yellow-white or canescence, stench, be mingled with not digested feedstuff or ziega in some feces, backward dehydro, enophthalmos impatient by hair; Chronic disease body temperature does not generally raise even lower than room temperature, and spirit is poor, loss of appetite, and walking is slow or stand transfixed to the ground, and repeatedly has loose bowels, and dehydration is serious, has pica, likes gnawing pad grass, drinking addle, severe anemia, and visual mucosa is pale, last exhaustion death.
Current control piglet diarrhea adopts antibacterial, the antiviral agents of chemosynthesis to feed or drug administration by injection usually, although temporarily can delay the state of an illness, cures the symptoms, not the disease, drops into large quantities of fund, reduces benefit of raising pigs.And some antiviral chemical drugs (as moroxydine, virazole etc.) is used for the treatment of Animal diseases by domestic having forbidden at present, and antimicrobial DP finish easily causes drug residue again, there is the drawback that treatment thoroughly can not cause secondary disease or slow virus infection.And Integrated TCM is applied in antibacterial, anti-virus aspect, there is original advantage, cheap, toxic and side effects is little, source is wide.Not only cost-saving, and interior symptom management can be asked when shorter, reduce piglet dead, and then improve culture benefit.Therefore, a kind of Chinese and western drugs compositions for piglet diarrhoea is badly in need of, for clinical practice.
Summary of the invention
The technical problem to be solved in the present invention overcomes at present in the weak point for the treatment of piglet diarrhea, provide one draw materials easy, easy to prepare, reduce drug residue and toxic and side effects, and the pharmaceutical composition of the higher treatment piglet diarrhea of cheap curative effect.We have overall curative effect high, not easily produce drug resistance, residual low, the advantage such as toxic and side effects is little, it has significant inhibitory action to the growth and reproduction of many pathogenic microorganisms, even can reach the pharmacological effect killing cause of disease, for promoting that the sound development of pig industry has very important economy and social meaning.
The invention provides following technical scheme: a kind of pharmaceutical composition for the treatment of piglet diarrhea, its crude drug composition by weight is
Gavage medicine 1: Herba Potentillae Chinensis 50-70 part, white Flos Hibisci 50-70 part, Herba polygoni hydropiperis 40-60 part, Radix Pulsatillae 40-60 part, Cortex Fraxini 40-60 part, Herba portulacae 20-40 part, Radix Curcumae 10-30 part, Rhizoma Atractylodis 10-30 part;
Gavage medicine 2: montmorillonite powder 3-7 part, cereobiogen sheet 3-7 part;
Preferred composition by weight is:
Gavage medicine 1: Herba Potentillae Chinensis 70 parts, white Flos Hibisci 70 parts, Herba polygoni hydropiperis 60 parts, the Radix Pulsatillae 60 parts, Cortex Fraxini 60 parts, Herba portulacae 40 parts, Radix Curcumae 30 parts, Rhizoma Atractylodis 30 parts;
Gavage medicine 2: montmorillonite powder 7 parts, cereobiogen sheet 7 parts.
Or be:
Gavage medicine 1: Herba Potentillae Chinensis 50 parts, white Flos Hibisci 50 parts, Herba polygoni hydropiperis 40 parts, the Radix Pulsatillae 40 parts, Cortex Fraxini 40 parts, Herba portulacae 20 parts, Radix Curcumae 10 parts, Rhizoma Atractylodis 10 parts;
Gavage medicine 2: montmorillonite powder 3 parts, cereobiogen sheet 3 parts.
Or be:
Gavage medicine 1: Herba Potentillae Chinensis 60 parts, white Flos Hibisci 60 parts, Herba polygoni hydropiperis 50 parts, the Radix Pulsatillae 50 parts, Cortex Fraxini 50 parts, Herba portulacae 30 parts, Radix Curcumae 20 parts, Rhizoma Atractylodis 20 parts;
Gavage medicine 2: montmorillonite powder 5 parts, cereobiogen sheet 5 parts.
Another object of the present invention be to provide a kind of treat the pharmaceutical composition of piglet diarrhea gavage medicine 1 preparation method:
Each Chinese medicine component is taken by a kind of proportioning raw materials for the treatment of the pharmaceutical composition of piglet diarrhea, Chinese medicine Herba Potentillae Chinensis, Herba polygoni hydropiperis, white Flos Hibisci, the Radix Pulsatillae, Cortex Fraxini, Herba portulacae, Radix Curcumae, Rhizoma Atractylodis are pulverized, decoct with water, filter medicinal residues, get filtrate, concentrated filtrate is to containing crude drug 0.66-0.70g/ml;
A kind of pharmaceutical composition for the treatment of piglet diarrhea of the present invention, in side, Herba Potentillae Chinensis is root or the whole herb with root of rosaceous plant Herba Potentillae Chinensis, and nature and flavor bitter cold, has the merit of heat-clearing and toxic substances removing, hemostasis, dysentery relieving.Have loose bowels for stomachache especially, chronic dysentery has good curative effect incessantly.White Flos Hibisci energy clearing away damp-heat, removing heat from blood are to control dysentery, and Herba Potentillae Chinensis shares, and can strengthen the curative effect of Herba Potentillae Chinensis.There is heat clearing and damp drying, the merit of cooling blood for hemostasis, for hygropyretic dysentery or diarrhoea effect fine.Flos Hibisci is divided into red white two kinds, and red person controls hemorrhoidal hamorrhage dysentery, and white person controls Hakuri, therefore diarrhoea with white Flos Hibisci treatment better.Herba polygoni hydropiperis is the dry herb of polygonaceae plant FUMAO knotweed, and nature and flavor are pungent, temperature.Return lung, liver, large intestine channel.There is removing toxic substances, damp eliminating, dissipating blood stasis, hemostasis.For dysentery, gastroenteritis, the curative effect of disease such as diarrhoea are certain.The Radix Pulsatillae can heat-clearing and toxic substances removing, and can enter again blood system and removing heat from blood antidiarrheal, especially kind clearing stomach intestinal is damp and hot, is the key medicine for the treatment of diarrhea due to damp-heat; Cortex Fraxini is bitter, cold.Enter liver, gallbladder, large intestine channel.Effect is heat clearing and damp drying, liver heat removing and eyesight improving.Can control damp-heat dysentery, normal being equal to the Radix Pulsatillae, is used.Herba portulacae heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, the cards such as pyretic stranguria, be used in particular for damp and hot caused diarrhoea, dysentery.Radix Curcumae is pungent, bitter, cold.Enter liver, the heart, lung meridian.There is removing heat from blood clear away heart-fire, the merit of promoting QI circulation for relieving depression.For the breast abdomen pain caused by damp-heat disease and qi stagnation hemagglutination.Rhizoma Atractylodis are pungent, bitter, temperature.Enter spleen, stomach warp.Have drying damp and strengthening spleen, the merit of relieving the exterior syndrome by diaphoresis.Montmorillonitum has another name called montmorillonite, is a kind of aluminosilicate.Clinically be applicable to the acute and chronic diarrhoea of people and animals.There is matured product montmorillonite powder at field of medicaments, almost become the synonym of Montmorillonitum, play antidiarrheal efficacy.Montmorillonitum pharmacological research shows, it has good adsorption to escherichia coli, vibrio cholera, campylobacter jejuni, staphylococcus aureus and rotavirus and cholate; Fixation is have to bacterial poison; Montmorillonitum only adsorbs, fixed surface with the pathogenic charged pathogen of grain encoding proteins (CS31 A), the normal flora of effects on surface not with CS31 A is without fixing scavenging action, and the uneven charging property of Montmorillonitum makes it can adsorb various digestive tract virulence factor.Montmorillonitum and digestive tract mucus protein electrostatical binding, can increase mucus amount and improve cohesiveness and the elasticity of mucus Quality advance mucus, thus playing protection and repair to gastrointestinal mucosal.The diarrhoea that Montmorillonitum causes the various cause of disease is all effective, is that bacillary, viral, lienteric, dysbiosis and intestinal poison bowel syndrome diarrhoea all has good curative effect.Montmorillonitum does not enter blood, gets rid of external completely, never residual, and any bacterial virus does not produce drug resistance to it, is green animal health product.Cereobiogen sheet is a safe and effective active bacteria formulation, without toxicity.Be mainly used in people and animals' diarrhoea, acute chronic enteritis, acute and chronic dysentery and bowel dysfunction etc., have good curative effect to the diarrhoea of piglet especially.
All medicines share the agent becoming heat clearing and damp drying antidiarrheal altogether.
The side's of system feature: we are with heat-clearing and toxic substances removing, and dampness removing and diarrhea-relieving use, hold concurrently with harmonizing the functional activities of vital QI, dispel pathogenic factor in the exterior, treating both the exterior and interior.
Said medicine is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country, enhances effect of the party's heat clearing and damp drying antidiarrheal, thus reaches the object of curing piglet diarrhea.The present invention passes through scientific compatibility, gavage medicine 1 to take the morning, gavage medicine 2 to take afternoon, two medicine separated in time are separately taken, Chinese medicine compound decoction and the medicine such as Montmorillonitum, cereobiogen are achieved organic assembling, can more effectively prevent and treat the various piglet diarrhea caused by bacillary and viral etc., curative effect safety non-toxic again really, strengthen the immunity of animal, improve raise benefit.Clinical Treatment Test proves, the cure rate 92.17% of we's treatment piglet diarrhea, effective percentage 99.40%.
Detailed description of the invention
embodiment 1
Gavage medicinal liquid 1 composition by weight: Herba Potentillae Chinensis 70 parts, white Flos Hibisci 70 parts, Herba polygoni hydropiperis 60 parts, the Radix Pulsatillae 60 parts, Cortex Fraxini 60 parts, Herba portulacae 40 parts, Radix Curcumae 30 parts, Rhizoma Atractylodis 30 parts.
Add water by 6 times of total dose, both 2520 parts of water, become 600 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.70 gram.
Gavage medicinal liquid 2 components by weight percent: Montmorillonitum 7 parts, cereobiogen 7 parts, add water by 5 times of total dose, both 70 parts of water, every milliliter of medicinal liquid is containing crude drug about 0.20 gram.
embodiment 2
Gavage medicinal liquid 1 composition by weight: Herba Potentillae Chinensis 50 parts, white Flos Hibisci 50 parts, Herba polygoni hydropiperis 40 parts, the Radix Pulsatillae 40 parts, Cortex Fraxini 40 parts, Herba portulacae 20 parts, Radix Curcumae 10 parts, Rhizoma Atractylodis 10 parts.
Add water by 6 times of total dose, both 1560 parts of water, become 394 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.66 gram.
Gavage medicinal liquid 2 components by weight percent: Montmorillonitum 3 parts, cereobiogen 3 parts, add water by 5 times of total dose, both 30 parts of water, every milliliter of medicinal liquid is containing crude drug about 0.20 gram.
embodiment 3
Gavage medicinal liquid 1 composition by weight: Herba Potentillae Chinensis 60 parts, white Flos Hibisci 60 parts, Herba polygoni hydropiperis 50 parts, the Radix Pulsatillae 50 parts, Cortex Fraxini 50 parts, Herba portulacae 30 parts, Radix Curcumae 20 parts, Rhizoma Atractylodis 20 parts.
Add water by 6 times of total dose, both 2040 parts of water, become 500 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid was containing crude drug about 0.68 gram.
Gavage medicinal liquid 2 components by weight percent: Montmorillonitum 5 parts, cereobiogen 5 parts, add water by 5 times of total dose, both 50 parts of water, every milliliter of medicinal liquid is containing crude drug about 0.20 gram.
embodiment 4
Gavage medicinal liquid 1: gavage medicine 1 proportioning by embodiment 1,2 or 3 and weigh, put into pot for boiling chinese traditional medicine, add water by proportional quantity, before decoction, first soak 40 minutes; Then heated and boiled, keeps temperature, decocts 30 minutes, and slagging-off, get filtrate, filtrate had both gavaged medicinal liquid 1.
Wherein
Embodiment 1 adds water 2520 parts, concentrated filtrate to 600 part;
Embodiment 2 adds water 1560 parts, concentrated filtrate to 394 part;
Embodiment 3 adds water 2040 parts, concentrated filtrate to 500 part;
Gavaging medicinal liquid 2: gavage medicine 2 proportioning by embodiment 1,2 or 3 and take montmorillonite powder and cereobiogen sheet, by mix homogeneously after two medicine pulverizes, put into container, add water by proportional quantity, stirring both for gavaging medicinal liquid 2.
experimental example
Instructions of taking:
1, dose: what embodiment 1, embodiment 4 are obtained gavages medicinal liquid 1, once gavages the morning by 4.5ml/kg body weight; What embodiment 2, embodiment 4 are obtained gavages medicinal liquid 1, once gavages the morning by 2.1ml/kg body weight; What embodiment 3, embodiment 4 are obtained gavages medicinal liquid 1, once gavages the morning by 3.06ml/kg body weight; .What embodiment 1, embodiment 4 are obtained gavages medicinal liquid 2, once gavages afternoon by 4.5ml/kg body weight; What embodiment 2, embodiment 4 are obtained gavages medicinal liquid 2, once gavages afternoon by 2.1ml/kg body weight; What embodiment 3, embodiment 4 are obtained gavages medicinal liquid 2, once gavages afternoon by 3.06ml/kg body weight;
2, medicine time: gavaging medicinal liquid 1 morning and afternoon every day respectively and gavage medicinal liquid 2, gavaging for last hour feeding.
3, medicine temperature control: about 40 DEG C decoction being taken warmly.
Taboo item: treatment period in a medicine strengthens feeding and management to ill piglet, ensures sufficient drinking-water, feeds to soft digestible feedstuff.
Criterion of therapeutical effect: the medicine composite for curing piglet diarrhea for the treatment of piglet diarrhea, whether efficacy determination Main Basis piglet diarrhea symptom disappears.Taking medicine 5 days is a course for the treatment of, and concrete curative effect is divided into three grades:
Cure: piglet diarrhea symptom all disappears;
Take a turn for the better: piglet diarrhea symptom partial disappearance;
Invalid: piglet diarrhea symptom is not improved.
In recent years, we, in thousands of examples of single therapeutic piglet diarrhea such as multiple pig farm and veterinary hospitals, treat a course for the treatment of, cure rate 92.17%, effective percentage 99.40%.
clinical effect trial
1. method: five, the pig farm of publishing cub's diarrhea of pigs, selects piglet 1266 example that piglet diarrhea occurs, age 7-35 age in days altogether.Ill piglet is divided into four groups, is respectively of the present invention group, Radix Pulsatillae side's group, Montmorillonitum add cereobiogen group and matched group.
Of the present invention group is the pharmaceutical composition by the treatment piglet diarrhea obtained by embodiment 3,4.
Radix Pulsatillae Decoction group Radix Pulsatillae Decoction used derives from treatise on Febrile Diseases, and it consists of the Radix Pulsatillae 60 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 45 parts, Cortex Fraxini 60 parts, and medicine is put into decoction pot, add water 1200 parts, decoct 30 minutes, slagging-off, get filtrate, gained filtrate is 287 parts, every milliliter contained 0.68 gram.
Montmorillonitum adds cereobiogen group both for gavaging medicinal liquid 2 in of the present invention group, and it consists of montmorillonite powder 5 parts, cereobiogen sheet 5 parts, adds water by 5 times of total dose, both 50 parts of water, every milliliter of medicinal liquid drug containing about 0.20 gram.
Matched group need not any Drug therapy.
Treatment time is a course for the treatment of, namely 5 days, and once, dosage presses 3.06ml/kg body weight to each medication of every day at upper and lower noon.
Table 1 suffers from poultry grouping and primary treatments
2. efficacy determination:
Criterion of therapeutical effect: whether the symptom of efficacy determination Main Basis piglet diarrhea disappears.Medication 5 days is a course for the treatment of, observe the curative effect after the course for the treatment of.Concrete curative effect is divided into three grades:
Cure: piglet diarrhea symptom all disappears;
Take a turn for the better: piglet diarrhea symptom partial disappearance;
Invalid: piglet diarrhea symptom is not improved.
3. result: 1266 routine ill piglets are by different dosage regimens, and after the treatment of a course for the treatment of, the therapeutic effect of each group is in table 2.
The various therapeutic scheme therapeutic effect of table 2
From table 2; three groups of medicines have different therapeutic effect to piglet diarrhea, and wherein best with of the present invention group of therapeutic effect, cure rate reaches 92.17%; total effective rate 99.40%, pole is significantly higher than other two groups (P < 0. 01); Radix Pulsatillae Decoction group is taken second place, and Montmorillonitum adds cereobiogen group again, and matched group does not have therapeutical effect.Statistical result shows, each group difference extremely significantly (P< 0. 01).
Facts have proved, medicine of the present invention is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country, enhances the party's heat-clearing and toxic substances removing, effect of dampness removing and diarrhea-relieving, have good curative effect for piglet diarrhea, thus reach the object of healing.The pharmaceutical composition of the treatment piglet diarrhea adopting the present invention a kind of preparation method for the treatment of the pharmaceutical composition of piglet diarrhea to obtain has that cost is low, preparation easily, to have no side effect and evident in efficacy.For this disease of clinical treatment provides a kind of practicable new drug.Clinical practice proves, the cure rate 92.17% of this medicine, effective percentage 99.40%.
Above-mentioned detailed description of pharmaceutical composition of this treatment piglet diarrhea and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (5)
1. treat a pharmaceutical composition for piglet diarrhea, its crude drug composition by weight is
Gavage medicine 1: Herba Potentillae Chinensis 50-70 part, white Flos Hibisci 50-70 part, Herba polygoni hydropiperis 40-60 part, Radix Pulsatillae 40-60 part, Cortex Fraxini 40-60 part, Herba portulacae 20-40 part, Radix Curcumae 10-30 part, Rhizoma Atractylodis 10-30 part;
Gavage medicine 2: montmorillonite powder 3-7 part, cereobiogen sheet 3-7 part.
2. a kind of pharmaceutical composition for the treatment of piglet diarrhea according to claim 1, is characterized in that:
Gavage medicine 1: Herba Potentillae Chinensis 70 parts, white Flos Hibisci 70 parts, Herba polygoni hydropiperis 60 parts, the Radix Pulsatillae 60 parts, Cortex Fraxini 60 parts, Herba portulacae 40 parts, Radix Curcumae 30 parts, Rhizoma Atractylodis 30 parts;
Gavage medicine 2: montmorillonite powder 7 parts, cereobiogen sheet 7 parts.
3. a kind of pharmaceutical composition for the treatment of piglet diarrhea according to claim 1, is characterized in that:
Gavage medicine 1: Herba Potentillae Chinensis 50 parts, white Flos Hibisci 50 parts, Herba polygoni hydropiperis 40 parts, the Radix Pulsatillae 40 parts, Cortex Fraxini 40 parts, Herba portulacae 20 parts, Radix Curcumae 10 parts, Rhizoma Atractylodis 10 parts;
Gavage medicine 2: montmorillonite powder 3 parts, cereobiogen sheet 3 parts.
4. a kind of pharmaceutical composition for the treatment of piglet diarrhea according to claim 1, is characterized in that:
Gavage medicine 1: Herba Potentillae Chinensis 60 parts, white Flos Hibisci 60 parts, Herba polygoni hydropiperis 50 parts, the Radix Pulsatillae 50 parts, Cortex Fraxini 50 parts, Herba portulacae 30 parts, Radix Curcumae 20 parts, Rhizoma Atractylodis 20 parts;
Gavage medicine 2: montmorillonite powder 5 parts, cereobiogen sheet 5 parts.
5. a kind of preparation method gavaging medicine 1 for the treatment of the pharmaceutical composition of piglet diarrhea according to claim 1:
Each Chinese medicine component is taken by a kind of proportioning raw materials for the treatment of the pharmaceutical composition of piglet diarrhea according to claim 1, Chinese medicine Herba Potentillae Chinensis, Herba polygoni hydropiperis, white Flos Hibisci, the Radix Pulsatillae, Cortex Fraxini, Herba portulacae, Radix Curcumae, Rhizoma Atractylodis are pulverized, decoct with water, filter medicinal residues, get filtrate, concentrated filtrate is to containing crude drug 0.66-0.70g/ml.
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| CN113827518A (en) * | 2021-09-27 | 2021-12-24 | 广州市科能化妆品科研有限公司 | Composition for inhibiting melanin generation, whitening composition, whitening emulsion and preparation thereof |
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| CN103655881A (en) * | 2013-12-18 | 2014-03-26 | 杨春晓 | Veterinary drug for treating livestock dysentery |
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| CN103655881A (en) * | 2013-12-18 | 2014-03-26 | 杨春晓 | Veterinary drug for treating livestock dysentery |
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| CN113827518A (en) * | 2021-09-27 | 2021-12-24 | 广州市科能化妆品科研有限公司 | Composition for inhibiting melanin generation, whitening composition, whitening emulsion and preparation thereof |
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