CN102580068A - Compound perfusate for treating mammitis of dairy cattle and preparation method thereof - Google Patents
Compound perfusate for treating mammitis of dairy cattle and preparation method thereof Download PDFInfo
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- CN102580068A CN102580068A CN2012100731243A CN201210073124A CN102580068A CN 102580068 A CN102580068 A CN 102580068A CN 2012100731243 A CN2012100731243 A CN 2012100731243A CN 201210073124 A CN201210073124 A CN 201210073124A CN 102580068 A CN102580068 A CN 102580068A
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Abstract
The invention relates to a compound perfusate for treating mammitis of dairy cattle. The compound perfusate is prepared from the following components: a sophora alopecuroide extract, a liquoric root extract, trypsin, chymotrypsin and papain through compatibility. according to a preparation method, Chinese medicines and protease are compounded, so that the compound perfusate for treating mammitis of dairy cattle has the effects of regulating the blood circulation of udders, inhibiting bacteria, diminishing inflammation and improving the immunity of organisms, is quick in response, low in toxic and side effect, convenient to use, high in bioavailability, safe and effective, and does not have medicinal residues.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly relate to a kind of perfusate of treating mammitis of cow and preparation method thereof.
Background technology
Mastitis is one of milch cow three big common diseases, and sickness rate is higher, and it not only has a strong impact on milk production, the milk-quality of ill cattle, prolongs post-partum estrus time and pregnant time, but also jeopardizes human health.
Mammitis of cow can be divided into clinic mastitis and latent mammitis.The clinical symptoms of clinic mastitis shows as the swelling of disease cow breast, heating, hyperemia, pain, and milk ejection is obstructed, milk is rare, even stops secretion, lymphadenectasis.Contain curdling piece or flocculent curd in the milk, weight person is mixed with blood, pus.Sick cattle is reluctant to stand up, and hind leg is said good-bye when walking, refusal young stock suckling and artificial milking.Appetite occurs, ruminate and reduce and lassitude, with the development of cattle disease journey, also can infect other mammary gland, lactation amount sharply descends, and extrudes clear water appearance and is mixed with the milk of floccule.Stealthy mastitis generally is difficult for coming to light in clinical production, observes not obviously, only shows as lactation amount and descends and the unstable properties of giving milk, generally will be through just making a definite diagnosis behind the lab testing; Stealthy mastitis generally is thoroughly not transformed and got by the clinic mastitis treatment.
The method of traditional treatment mammitis of cow adopts antibiotherapy more, promptly at local penicillin, streptomycin, oxytetracycline, the kanamycin etc. of using of breast, but long-time the repeated use; The drug resistance that easy generation is stronger; Dosage increases year by year, is prone to cause antibiotic remains simultaneously, influences human health.Therefore become a new research direction with Chinese medicine and other non-antibiotic treatment mammitis of cow.
Summary of the invention
The object of the present invention is to provide a kind of effective treatment clinic mastitis and latent mammitis, therapeutic effect is remarkable, and is rapid-action, at the bottom of the toxic and side effects, and the perfusate of the treatment mammitis of cow of noresidue;
Another object of the present invention provides the method for preparing of above-mentioned perfusate.
For realizing that the technical scheme that the foregoing invention purpose is taked is:
A kind of perfusate of treating mammitis of cow is characterized in that the main pharmacodynamics of this infusion liquid consists of the following weight proportion raw material:
Herba Sophorae alopecuroidis extract 1-10 part,
Radix Glycyrrhizae extract 1-5 part,
Trypsin 0.2-2 part,
Chymotrypsin 0.2-2 part,
Papain 0.1-1 part.
The method for preparing of the perfusate of above-mentioned treatment mammitis of cow, its technical process comprises:
⑴ the preparation of Herba Sophorae alopecuroidis extract: sophora alopecuroide or Sophora Alopecuroides L. are ground into coarse powder, add 10 times of amounts, the extraction of 45%-75% ethanol continuous backflow, concentrate and reclaim ethanol; Concentrated solution adds the water dilution that 1-1.5 doubly measures, and adds hydrochloric acid adjust pH 3-4, and 1-3 doubly measures absolute ether and extracts 3 times (defat); Acid liquid hydro-oxidation sodium is transferred more than the pH13, adds methylene chloride to extract (consumption is followed successively by 3 times of amounts, 2 times of amounts and 1 times of amount), combined dichloromethane extracting solution 3 times; Reclaim dichloromethane, concentrated solution is dissolved in 65% the ethanol, filters; Reclaim ethanol to thick paste shape, vacuum drying is to Powdered, and it is subsequent use to get Herba Sophorae alopecuroidis extract.
⑵ the preparation of Radix Glycyrrhizae extract: the extracting liquorice decoction pieces, with the alcoholic solution reflux, extract, of 5%-10% 3 times, each alcoholic solution consumption be 8-10 doubly; Merge extractive liquid, after placement is spent the night, is got supernatant liquid filtering; Filtrating is concentrated into thick paste, and vacuum drying is to Powdered, and it is subsequent use to get Radix Glycyrrhizae extract.
⑶ get Herba Sophorae alopecuroidis extract 1-10 part and Radix Glycyrrhizae extract 1-5 part, and adding distil water 5-10 part stirs, and after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filtered, sterilization, fill became injection in glass ampule.
⑷ get Trypsin trypsin 0.2-2 part, Chymotrypsin 0.2-2 part, papain 0.1-1 part; Adding distil water 2-10 part; Behind the dissolving mix homogeneously, microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, and filtrating is spray dried to Powdered; Under aseptic condition, be divided in the cillin bottle, become injectable sterile powder.
⑸ during clinical use, carry out the breast perfusion of milch cow after with the injection of Herba Sophorae alopecuroidis extract and Radix Glycyrrhizae extract preparation the sterilized powder dissolving of protease being mixed.
The present invention develops according to the pathogeny of Chinese veterinarian's theory and mammitis of cow, has the adjusting blood circulation of breast, inhibiting bacteria and diminishing inflammation and human body immunity improving power effect.
Herba Sophorae alopecuroidis extract in the prescription of the present invention has antipyretic-antalgic, inhibiting bacteria and diminishing inflammation, the effect of raising immunity; Radix Glycyrrhizae extract has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, the effect of relieving spasm to stop pain; Trypsin, Chymotrypsin and papain coupling degradable thrombosis, fibrin and slough reduce the phagocytosis that the serum viscosity also can strengthen macrophage, can improve the microcirculation of focus generating region simultaneously, recover dynamic equilibrium.All medicine compatibilities, combined effect make prescription have heat-clearing and toxic substances removing, regulate blood circulation of breast, inhibiting bacteria and diminishing inflammation and human body immunity improving power effect.
The present invention is composite with Chinese prescription and protease, is used to treat mammitis of cow, has that onset speed is fast, toxic and side effects is low, a drug residue free, easy to use, characteristics that bioavailability is high, is one to treat the compound filling agent of mammitis of cow safely and effectively.
The specific embodiment
With instance the present invention is described below, it should be understood that instance is to be used to explain the present invention rather than limitation of the present invention.Scope of the present invention and core content are confirmed according to claims.
Embodiment 1
A kind of perfusate of treating mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 5kg, Radix Glycyrrhizae extract 2kg, trypsin 0.4kg, Chymotrypsin 0.2kg, papain 0.1kg.
Its preparation method is:
⑴ sophora alopecuroide is ground into coarse powder, and the 60% ethanol continuous backflow that adds 10 times is extracted, and concentrates and reclaims ethanol, and concentrated solution adds the water dilution of 1 times of amount; Add hydrochloric acid adjust pH 3-4, absolute ether extracts 3 times, the absolute ether of each 2.5 times of amounts; Acid liquid hydro-oxidation sodium is transferred more than the pH13, adds methylene chloride to extract (amount of 3 adding dichloromethane is respectively 3 times of amounts, 2 times of amounts, 2 times of amounts), combined dichloromethane extracting solution 3 times; Reclaim dichloromethane, concentrated solution is dissolved in 65% the ethanol, filters; Reclaim ethanol to thick paste shape, vacuum drying is to Powdered, and it is subsequent use to get Herba Sophorae alopecuroidis extract.
⑵ extracting liquorice decoction pieces, the alcoholic solution reflux, extract, with 5% 3 times (each alcoholic solution consumption is respectively 8 times of amounts), merge extractive liquid; After placement is spent the night, get supernatant liquid filtering, filtrating is concentrated into thick paste; Vacuum drying (temperature is 65～75 ℃) is to Powdered, and it is subsequent use to get Radix Glycyrrhizae extract.
⑶ get Herba Sophorae alopecuroidis and extract Herba Sophorae alopecuroidis extract 5kg and Radix Glycyrrhizae extract 2kg, and adding distil water 20kg stirs, and after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filtered, sterilization, fill became the injection of every dress 10ml.
⑷ get trypsin 0.4kg, Chymotrypsin 0.2kg, papain 0.1kg; Adding distil water 2kg mixed dissolution; After microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, be spray dried to Powderedly, fill becomes the injectable sterile powder of every dress 1g under aseptic condition.
⑸ during clinical use, get a pheron sterilized powder, carry out the breast perfusion of milch cow after mixing with the injection dissolving of two Chinese medicine extract.
Clinical practice test effect: be used for 15 of the milch cows that Litong District milk cattle cultivating base, Wuzhong, Ningxia treatment suffers from clinical type mammitis of cow; Before the treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node; The thin flocculus that contains of milk is diagnosed as the serosity mastitis through clinical examination.Method of treatment: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage 100%, and after 7-12 days, 13 cow heads are cured, and cure rate is 86%.
Embodiment 2
A kind of perfusate of treating mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 8kg, Radix Glycyrrhizae extract 4kg, trypsin 0.5kg, Chymotrypsin 0.5kg, papain 0.2kg.
Its preparation method is following:
⑴ Sophora Alopecuroides L. is ground into coarse powder, and the 45% ethanol continuous backflow that adds 10 times is extracted, and concentrates and reclaims ethanol, and concentrated solution adds the water dilution of 1.5 times of amounts; Add hydrochloric acid adjust pH 3-4, absolute ether extracts 3 times, the absolute ether of each 2.5 times of amounts; Acid liquid hydro-oxidation sodium is transferred more than the pH13, adds methylene chloride to extract (amount of 3 adding dichloromethane is respectively 3 times of amounts, 2 times of amounts, 2 times of amounts), combined dichloromethane extracting solution 3 times; Reclaim dichloromethane, concentrated solution is dissolved in 65% the ethanol, filters; Reclaim ethanol to thick paste shape, vacuum drying is to Powdered, and it is subsequent use to get Herba Sophorae alopecuroidis extract.
⑵ extracting liquorice decoction pieces, the alcoholic solution reflux, extract, with 8% 3 times (each alcoholic solution consumption is respectively 10 times of amounts), merge extractive liquid; After placement is spent the night, get supernatant liquid filtering, filtrating is concentrated into thick paste; Vacuum drying (temperature is 65～75 ℃) is to Powdered, and it is subsequent use to get Radix Glycyrrhizae extract.
⑶ get Herba Sophorae alopecuroidis and extract Herba Sophorae alopecuroidis extract 8kg and Radix Glycyrrhizae extract 4kg, and adding distil water 20kg stirs, and after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filtered, sterilization, fill became the injection of every dress 10ml.
⑷ get trypsin 0.5kg, Chymotrypsin 0.5kg, papain 0.2kg; Adding distil water 2kg mixed dissolution; After microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, be spray dried to Powderedly, fill becomes the injectable sterile powder of every dress 1g under aseptic condition.
⑸ during clinical use, get a pheron sterilized powder, carry out the breast perfusion of milch cow after mixing with the injection dissolving of two Chinese medicine extract.
Clinical practice test effect: be used for 17 of the milch cows that Litong District milk cattle cultivating base, Wuzhong, Ningxia treatment suffers from clinical type mammitis of cow; The ill domestic animal symptom is that newborn matter is thin and amount is few before the treatment; On inspection; Somatic cell is 650,000/ml, and other unclear symptoms shows, and is diagnosed as stealthy mastitis through clinical examination.Method of treatment: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, and effective percentage is after 100%, 7 day, and 16 cow heads are cured, and 200,000/ml is reduced in somatic cell, and cure rate is 94%.
Embodiment 3
A kind of perfusate of treating mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 1kg, Radix Glycyrrhizae extract 1kg, trypsin 0.2kg, Chymotrypsin 2kg, papain 0.8kg.
Method for preparing is with embodiment 1.
Clinical practice test effect: be used for 20 of the milch cows that milk cattle cultivating district, Yinchuan City, Ningxia treatment suffers from clinical type mammitis of cow; Before the treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node; The thin flocculus that contains of milk is diagnosed as the serosity mastitis through clinical examination.Method of treatment: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage 100%, and after 7-10 days, 18 cow heads are cured, and cure rate is 90%.
Embodiment 4
A kind of perfusate of treating mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 10kg, Radix Glycyrrhizae extract 4kg, trypsin 2kg, Chymotrypsin 1kg, papain 0.6kg.
Method for preparing is with embodiment 1.
The clinical practice test effect: be used for 12 of the milch cows that milk cattle cultivating district, Yinchuan, Ningxia treatment suffers from clinical type mammitis of cow, the ill domestic animal symptom is that newborn matter is thin and amount is few before the treatment, and other unclear symptoms shows, and is diagnosed as stealthy mastitis through clinical examination.Method of treatment: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, and effective percentage is after 100%, 7 day, and 11 cow heads are cured, and cure rate is 91%.
Embodiment 5
A kind of perfusate of treating mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 6kg, Radix Glycyrrhizae extract 5kg, trypsin 1.2kg, Chymotrypsin 1.5kg, papain 1kg.
Method for preparing is with embodiment 1.
Clinical practice test effect: be used for 15 of the milch cows that Litong District milk cattle cultivating base, Wuzhong, Ningxia treatment suffers from clinical type mammitis of cow; Before the treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node; Acinus, lactiferous ducts degeneration, the also toughness exudate that comes off are diagnosed as the mucus mastitis through clinical examination.Method of treatment: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, and effective percentage is after 100%, 7 day, and 12 cow heads are cured, and cure rate is 80%.
Claims (10)
1. perfusate of treating mammitis of cow is characterized in that the main pharmacodynamics of this infusion liquid consists of the following weight proportion raw material:
Herba Sophorae alopecuroidis extract 1-10 part,
Radix Glycyrrhizae extract 1-5 part,
Trypsin 0.2-2 part,
Chymotrypsin 0.2-2 part,
Papain 0.1-1 part.
2. method for preparing of treating the perfusate of mammitis of cow, its technical process comprises:
A. with the Herba Sophorae alopecuroidis extract and the Radix Glycyrrhizae extract adding distil water of formula ratio, stir, sterilize behind the filtering with microporous membrane, fill obtains injection;
B. trypsin, Chymotrypsin and the papain of formula ratio are used dissolved in distilled water, behind the mix homogeneously, filtering with microporous membrane, filtrating is spray dried to Powdered, and packing obtains injectable sterile powder under aseptic condition.
3. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 2, the consumption that it is characterized in that above-mentioned Herba Sophorae alopecuroidis extract, Radix Glycyrrhizae extract and distilled water is 1-10 part, 1-5 part and 5-10 part.
4. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 3, it is characterized in that above-mentioned Herba Sophorae alopecuroidis extract adopts following method to obtain: sophora alopecuroide or Sophora Alopecuroides L. coarse powder are extracted with 45%-75% ethanol continuous backflow, concentrate recovery ethanol; The concentrated solution thin up, adjust pH 3-4 adds absolute ether and extracts; More than 13, dichloromethane is reclaimed in the extraction that adds methylene chloride to the gained acid liquid with adjusting PH with base; Concentrated solution is dissolved in 65% the ethanol, filters, and reclaims ethanol to thick paste shape; Vacuum drying gets Herba Sophorae alopecuroidis extract to Powdered.
5. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 4, it is characterized in that: amount of ethanol is sophora alopecuroide or Sophora Alopecuroides L. coarse powder 10 times in the above-mentioned ethanol continuous backflow.
6. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 4, it is characterized in that: above-mentioned concentrated solution adds the water dilution that 1-1.5 doubly measures.
7. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 4, it is characterized in that: above-mentionedly extract 3 times the absolute ether of at every turn doubly measuring with absolute ether with 1-3.
8. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 4, it is characterized in that: above-mentioned with dichloromethane extraction 3 times, consumption is followed successively by 3 times of amounts, 2 times of amounts and 1 times of amount.
9. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 3; It is characterized in that said Radix Glycyrrhizae extract adopts following method to obtain: with the alcoholic solution reflux, extract, of licorice piece with 5%-10%, the alcoholic solution consumption is 8-10 a times of licorice piece, after placement is spent the night; Get supernatant liquid filtering; Filtrating is concentrated into thick paste, and vacuum drying gets Radix Glycyrrhizae extract to Powdered.
10. according to the method for preparing of the perfusate of the described treatment mammitis of cow of claim 2, the consumption that it is characterized in that above-mentioned trypsin, Chymotrypsin, papain and distilled water is 0.2-2 part, 0.2-2 part, 0.2-2 part and 2-10 part.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142683A (en) * | 2013-03-12 | 2013-06-12 | 广东海纳川药业股份有限公司 | Sophora alopecuroide total alkaloid-containing traditional Chinese medicine perfusion fluid for treating bovine mastitis and endometritis as well as preparation method of perfusion fluid |
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| CN101406515A (en) * | 2008-12-02 | 2009-04-15 | 黑龙江省汇丰动物保健品有限公司 | Breast perfusate for treating mammitis of milk cattle and preparation thereof |
| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
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- 2012-03-20 CN CN201210073124.3A patent/CN102580068B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406515A (en) * | 2008-12-02 | 2009-04-15 | 黑龙江省汇丰动物保健品有限公司 | Breast perfusate for treating mammitis of milk cattle and preparation thereof |
| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142683A (en) * | 2013-03-12 | 2013-06-12 | 广东海纳川药业股份有限公司 | Sophora alopecuroide total alkaloid-containing traditional Chinese medicine perfusion fluid for treating bovine mastitis and endometritis as well as preparation method of perfusion fluid |
| CN103142683B (en) * | 2013-03-12 | 2015-09-09 | 广东海纳川生物科技股份有限公司 | Be used for the treatment of Chinese medicinal perfusion liquid containing Herba Sophorae alopecuroidis total alkali of bovine mastitis and endometritis and preparation method thereof |
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