CN102058667A - Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof - Google Patents
Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof Download PDFInfo
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- CN102058667A CN102058667A CN 201110002218 CN201110002218A CN102058667A CN 102058667 A CN102058667 A CN 102058667A CN 201110002218 CN201110002218 CN 201110002218 CN 201110002218 A CN201110002218 A CN 201110002218A CN 102058667 A CN102058667 A CN 102058667A
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Abstract
The invention relates to a Chinese medical intramammary infusion for treating the mastitis of dairy cows, which is prepared by the following raw materials in proportions: 2-6 grams of dandelion, 1-4 grams of honeysuckle, 1-4 grams of scutellaria baicalensis georgi, 1-4 grams of radix isatidis, and 1-4 grams of angelica; the infusion also comprises 0.01-0.02 grams of sodium carboxymethylcellulose, 5-20 millilitres of propylene glycol, and 5-10 millilitres of Tween-80. The infusion of the invention is mainly prepared by Chinese herbal medicines has the advantages of antibacterium, anti-inflammation, low toxicity, no residues, small irritation for the dairy cows and lower cost, is difficult to generate medicine resistance, can effectively treat the mastitis of the dairy cows and ensures that dairy farmers and dairy cow breeding enterprises obtain better economic benefit.
Description
Technical field
This method relates generally to the medicine of treatment mammitis of cow, especially a kind of pure Chinese medicinal perfusion liquid that is used for the treatment of mammitis of cow, and the preparation method of this infusion liquid.
Background technology
Mastitis be a worldwide problem.At present, the whole world has 2.2 hundred million cow heads approximately, and wherein 1/3 suffers from various types of mastitiss.According to international milch cow community statistics, latent mammitis prevalence in the galactopoiesis milch cow reaches 50%.West Europe part developed country bovine subclinical mastitis sickness rate is also up to 25%.The drove investigation shows that the cow of the U.S. 30%-70% has an infected breast district at least.The incidence rate of China's mammitis of cow is higher, and the morbidity number of the mammitis of cow of Beijing area accounts for 21%-23% of the milch cow morbidity sum of growing up, and is only second to digestive disease, occupies second; The death toll that mammitis of cow causes accounts for 8%-10% of the milch cow that grows up, and is only second to reproductive disease and acropathy, housing the 3rd.This shows that mammitis of cow is current harm dairy development, a kind of important diseases that the restriction milch cow produces is worth milch cow Producer and animal and veterinary worker's great attention and concern.
The main cause that the causes mammitis of cow pathogenic microorganism that has been intramammary infection, at present to the treatment of this disease mostly based on antibiotic.Antibiotic is long-term, extensively, heavy dose is used for the treatment of mammitis of cow and caused a series of adverse consequencess: at first be milch cow and milk drug residue, people's health had a negative impact; Next is that Resistant strain increases, pathogenic bacterium produce drug resistance, be that mastitis becomes more and more refractory more, people have to strengthen antibiotic using dosage like this, and this has increased the weight of the danger of drug residue again, and other residual harm of medicine comprise that also the sweat in the milk product production is suppressed, cause the output and the quality of product to reduce, the demand of adding present milk product is increasing, and safety factor also is not allow the problem ignored, so antibiotic use has been subjected to serious restriction.
In secular practice, Chinese medicine veterinary has accumulated abundant clinical experience and a large amount of Chinese medicine formulas to the control bovine mastitis, though there is the not clear defective of composition, but pure natural substance contains multiple biological effective components, have antibiotic, antiinflammatory, low toxicity, low-residual or noresidue, be difficult for producing bacterial drug resistance, and the infusion liquid zest is less, and is with low cost, and Chinese medicinal perfusion liquid of the present invention provides the approach of better solution mammitis of cow problem for vast milk cattle cultivating family.
Summary of the invention
The object of the invention is to provide a kind of, noresidue little to the milch cow zest and can effectively treats the Chinese medicinal perfusion liquid of mammitis of cow.
The present invention also provides the preparation method of this Chinese medicinal perfusion liquid.
For achieving the above object, the present invention adopts following technical scheme:
A kind of Chinese medicine breast perfusate for the treatment of mammitis of cow, this infusion liquid is mainly made by the Chinese crude drug of following proportioning: Herba Taraxaci 2～6g, Flos Lonicerae 1～4g, Radix Scutellariae 1～4g, Radix Isatidis 1～4g, Radix Angelicae Sinensis 1～4g.
Above-mentioned Chinese medicine breast perfusate also contains sodium carboxymethyl cellulose 0.01～0.02g, propylene glycol 5～20ml, Tween-80 5～10ml.This infusion liquid pH is 6.5～7.0.
The preparation method of above-mentioned Chinese medicine breast perfusate may further comprise the steps:
1. get Herba Taraxaci, Flos Lonicerae, Radix Scutellariae, Radix Isatidis and Radix Angelicae Sinensis, pulverized 100 mesh sieves, add 80～90ml distilled water then, soak 3h, put in the multi-function extractor and extract 3 times, filter the back merging filtrate, it is 1.20～1.25g/cm that filtrate is concentrated into density
3(can measure the density of filtrate with gravimeter) gets a;
2. in the 100ml distilled water, add sodium carboxymethyl cellulose, grind 30～40min and get b;
3. in a, add propylene glycol and Tween-80, grind 10～20min, add b again, equidirectional grinding 10～20min, add the injection water and be settled to 1000ml, (generally the dosage of lactic acid is 5～20ml) adjusting pH to 6.5～7.0, after continuing to grind 30～40min, gets finished product after fill, sterilization with lactic acid.
Described grinding is carried out on homogenizer.3. described step is sterilized and is adopted flowing steam sterilization 30～40min.
The effect of Chinese medicine of the present invention: with the Herba Taraxaci is monarch, and it has the effect of heat-clearing and toxic substances removing, sterilization eliminating stagnation, wind-heat dissipating; Flos Lonicerae and Radix Scutellariae are ministerial drug altogether, and auxilliary monarch drug strengthens the effect of antiinflammatory, treatment carbuncle sore tumefacting virus; When being classified as adjuvant drug, its blood circulation promoting and enriching ends sick; Radix Isatidis is a messenger drug, above-mentioned all material combinations are reasonable, complement each other, and has strengthened the effect of medicine heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation to remove obstruction in the collateral, anti-inflammatory analgetic, active lactogenesis after the mediation.
Compare beneficial effect of the present invention with prior art:
Employing is the infusion liquid of main preparation with the Chinese herbal medicine, advantages such as having antibiotic, antiinflammatory, low toxicity, noresidue, be difficult for producing antibacterial, drug resistance is strong, and little to the milch cow zest, cost is lower, can effectively treat the mastitis problem of milch cow, make dairy farmer and milk cattle cultivating enterprise obtain favorable economic benefit.
The specific embodiment
The present invention is described further by the following examples, but protection scope of the present invention is not limited thereto.
Embodiment 1-4:
A kind of Chinese medicine breast perfusate for the treatment of mammitis of cow, each proportioning raw materials of this infusion liquid sees table 1 for details:
The preparation method of described Chinese medicine breast perfusate is described in detail in detail with embodiment 1:
1. get 5g Herba Taraxaci, 3g Flos Lonicerae, 4g Radix Scutellariae, 2g Radix Isatidis and 2g Radix Angelicae Sinensis, pulverized 100 mesh sieves, add the 90ml distilled water then, soak 3h, put in the multi-function extractor (Shanghai Yuanyue Light Industry and Machinery Co., Ltd.'s production) and extract 3 times, filter the back merging filtrate, it is 1.25g/cm that filtrate is concentrated into density
3, get a;
2. in the 100ml distilled water, add 0.01 part of sodium carboxymethyl cellulose, on homogenizer, grind 30min and get b;
3. in a, add 15ml propylene glycol and 5mlTween-80, grind 20min, add b again, equidirectional grinding 20min adds the injection water and is settled to 1000ml, and adding 10ml lactic acid adjusting pH is 7.0, after continuing to grind 30min, behind fill, flowing steam sterilization 30min, get finished product.
The test of pesticide effectiveness:
(1) experiment material
Choose 24 of the milch cows (about body weight 400kg) that body condition is close, suffer from mastitis from certain large-scale cattle farm, be divided into three groups at random, be Chinese drug-treated group (product of perfusion embodiment 1), Western medicine group (perfusion ciprofloxacin lactate, every 100ml contains the 0.2g ciprofloxacin) and blank group.
(2) test method and dosage: Chinese drug-treated group and Western medicine group breast perfusion every group of every day be (30ml/ head) once, and 3 days is a course of treatment, continuous use 6 days, and result of the test sees Table 2.
(3) clinical symptoms and curative effect determinate standard:
Clinical symptoms: mainly showing as breast and milk all has macroscopic unusual.Breast slightly generates heat, and owing to pain is refused suckling and milking, the Ipsilateral limb is walked lamely.Galactopoiesis reduces, and flocculus, grumeleuse are arranged in the milk, is water sample sometimes, and milk color, taste are unusual.Acute inflammation with fervescence, loss of appetite, spirit is depressed, lactogenic reduces or stop.
After medication, take a turn for the better show as breast red, swollen, hot, bitterly, symptom weakens firmly, a small amount of floccule is arranged in the milk, but the color and luster of milk is no abnormal, the milk yield rise; Cure show as breast redness, heat, bitterly, hard transference cure, the milk perusal is normal, milk yield is recovered substantially; Invalidly show as each above-mentioned clinical symptoms and do not alleviate or aggravate.Effective percentage is improvement rate and cure rate sum.
Test data adopts SPSS13.0 software to analyze, and analyzes with the remarkable method of minimum difference (LSD) between per two groups.As can be seen from Table 2, though Chinese drug-treated group milch cow treatment effective percentage and Western medicine group is the same, be 75% (P＜0.05), but those skilled in the art know, use the western medicine mammitis of cow to cause milk matter to descend because of producing drug resistance and drug residue easily, not only low-toxicity green environmental protection of utilization treatment by Chinese herbs, be difficult for producing drug residue and antibacterial, and effective, drug resistance is strong, little to the milch cow zest, cost is lower, can make dairy farmer and milk cattle cultivating enterprise obtain favorable economic benefit.
Claims (6)
1. a Chinese medicine breast perfusate for the treatment of mammitis of cow is characterized in that this infusion liquid is mainly made by the Chinese crude drug of following proportioning: Herba Taraxaci 2～6g, Flos Lonicerae 1～4g, Radix Scutellariae 1～4g, Radix Isatidis 1～4g, Radix Angelicae Sinensis 1～4g.
2. Chinese medicine breast perfusate as claimed in claim 1 is characterized in that, also contains sodium carboxymethyl cellulose 0.01～0.02g, propylene glycol 5～20ml, Tween-80 5～10ml.
3. Chinese medicine breast perfusate as claimed in claim 1 is characterized in that, this infusion liquid pH is 6.5～7.0.
4. the preparation method of claim 2 or 3 described Chinese medicine breast perfusates is characterized in that, may further comprise the steps:
1. get Herba Taraxaci, Flos Lonicerae, Radix Scutellariae, Radix Isatidis and Radix Angelicae Sinensis, pulverized 100 mesh sieves, add 80～90ml distilled water then, soak 3h, put in the multi-function extractor and extract 3 times, filter the back merging filtrate, it is 1.20～1.25g/cm that filtrate is concentrated into density
3, get a;
2. in the 100ml distilled water, add sodium carboxymethyl cellulose, grind 30～40min and get b;
3. add propylene glycol and Tween-80 in a, grind 10～20min, add b again, equidirectional grinding 10～20min adds the injection water and is settled to 1000ml, regulates pH to 6.5～7.0 with lactic acid, after continuing to grind 30～40min, after fill, sterilization finished product.
5. the preparation method of the described Chinese medicine breast perfusate of claim 4 is characterized in that, described grinding is carried out on homogenizer.
6. the preparation method of the described Chinese medicine breast perfusate of claim 4 is characterized in that, 3. described step is sterilized and adopted flowing steam sterilization 30～40min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100022187A CN102058667B (en) | 2011-01-07 | 2011-01-07 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
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| CN2011100022187A CN102058667B (en) | 2011-01-07 | 2011-01-07 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
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| CN102058667A true CN102058667A (en) | 2011-05-18 |
| CN102058667B CN102058667B (en) | 2012-04-18 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580068A (en) * | 2012-03-20 | 2012-07-18 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN108245587A (en) * | 2018-04-10 | 2018-07-06 | 宁夏智弘生物科技有限公司 | A kind of compound breast injection and preparation method thereof |
| CN110833570A (en) * | 2019-12-19 | 2020-02-25 | 元亨生物技术有限公司 | Preparation method of three-flower Chinese angelica perfusate |
| CN113440556A (en) * | 2021-06-23 | 2021-09-28 | 山西恒之源工贸有限公司 | Material for promoting blood circulation to remove blood stasis and clearing heat and cooling blood and cushion thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823903A (en) * | 2005-12-31 | 2006-08-30 | 天津生机集团 | Yinghuang breast filling liquid, its preparation method and use |
| CN1965976A (en) * | 2006-11-05 | 2007-05-23 | 武瑞 | Chinese medicinal composition for preventing and treating cow mastitis |
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- 2011-01-07 CN CN2011100022187A patent/CN102058667B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823903A (en) * | 2005-12-31 | 2006-08-30 | 天津生机集团 | Yinghuang breast filling liquid, its preparation method and use |
| CN1965976A (en) * | 2006-11-05 | 2007-05-23 | 武瑞 | Chinese medicinal composition for preventing and treating cow mastitis |
Non-Patent Citations (1)
| Title |
|---|
| 《山东畜牧兽医》 20061030 高玉君等 中草药对奶牛乳腺炎病原菌的体外抑菌试验 1-2 1-6 , 第05期 2 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580068A (en) * | 2012-03-20 | 2012-07-18 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN102580068B (en) * | 2012-03-20 | 2014-02-12 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN108245587A (en) * | 2018-04-10 | 2018-07-06 | 宁夏智弘生物科技有限公司 | A kind of compound breast injection and preparation method thereof |
| CN110833570A (en) * | 2019-12-19 | 2020-02-25 | 元亨生物技术有限公司 | Preparation method of three-flower Chinese angelica perfusate |
| CN113440556A (en) * | 2021-06-23 | 2021-09-28 | 山西恒之源工贸有限公司 | Material for promoting blood circulation to remove blood stasis and clearing heat and cooling blood and cushion thereof |
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| CN102058667B (en) | 2012-04-18 |
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