CN102580068B - Compound perfusate for treating mammitis of dairy cattle and preparation method thereof - Google Patents
Compound perfusate for treating mammitis of dairy cattle and preparation method thereof Download PDFInfo
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- CN102580068B CN102580068B CN201210073124.3A CN201210073124A CN102580068B CN 102580068 B CN102580068 B CN 102580068B CN 201210073124 A CN201210073124 A CN 201210073124A CN 102580068 B CN102580068 B CN 102580068B
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Abstract
The invention relates to a compound perfusate for treating mammitis of dairy cattle. The compound perfusate is prepared from the following components: a sophora alopecuroide extract, a liquoric root extract, trypsin, chymotrypsin and papain through compatibility. according to a preparation method, Chinese medicines and protease are compounded, so that the compound perfusate for treating mammitis of dairy cattle has the effects of regulating the blood circulation of udders, inhibiting bacteria, diminishing inflammation and improving the immunity of organisms, is quick in response, low in toxic and side effect, convenient to use, high in bioavailability, safe and effective, and does not have medicinal residues.
Description
Technical field
The invention belongs to veterinary drug technical field, particularly relate to a kind of perfusate for the treatment of mammitis of cow and preparation method thereof.
Background technology
Mastitis is one of milch cow three large common diseases, and sickness rate is higher, and it not only has a strong impact on milk production, the milk-quality of ill cattle, extends post-partum estrus time and pregnant time, but also jeopardizes human health.
Mammitis of cow can be divided into clinic mastitis and latent mammitis.The clinical symptoms of clinic mastitis shows as the swelling of disease cow breast, heating, hyperemia, pain, and milk ejection is obstructed, milk is rare, even stops secretion, lymphadenectasis.In milk, containing curdling piece or flocculent curd, severe one is mixed with blood, pus.Sick cattle is reluctant to stand up, and while walking, hind leg is said good-bye, refusal young stock suckling and artificial milking.Occur appetite, ruminate and reduce and lassitude, with the development of cattle disease journey, also can infect other mammary gland, lactation amount sharply declines, and extrudes clear water sample and is mixed with the milk of floccule.Recessive mastitis is generally difficult for being found in clinical production, observes not obviously, only shows as that lactation amount declines and Milk Production is unstable, and generally chamber just can be made a definite diagnosis after checking by experiment; Recessive mastitis is generally to be treated and thoroughly do not transformed and obtain by clinic mastitis.
The method of traditional treatment mammitis of cow adopts antibiotherapy more, at breast local application of penicillin, streptomycin, oxytetracycline, kanamycin etc., but reuses for a long time, easily produce stronger drug resistance, dosage increases year by year, easily causes antibiotic remains simultaneously, affects human health.Therefore with Chinese medicine and other non-antibiotic treatment mammitis of cow, become a new research direction.
Summary of the invention
The object of the present invention is to provide a kind of effective treatment clinic mastitis and latent mammitis, therapeutic effect is remarkable, rapid-action, at the bottom of toxic and side effects, and the perfusate of the treatment mammitis of cow of noresidue;
Another object of the present invention is to provide the preparation method of above-mentioned perfusate.
The technical scheme taked is for achieving the above object:
Treat a perfusate for mammitis of cow, it is characterized in that the main pharmacodynamics of this infusion liquid consists of the raw material of following weight proportioning:
Herba Sophorae alopecuroidis extract 1-10 part,
Radix Glycyrrhizae extract 1-5 part,
Trypsin 0.2-2 part,
Chymotrypsin 0.2-2 part,
Papain 0.1-1 part.
The preparation method of the perfusate of above-mentioned treatment mammitis of cow, its technical process comprises:
(1) the preparation of Herba Sophorae alopecuroidis extract: sophora alopecuroide or Sophora Alopecuroides L. are ground into coarse powder, add 10 times of amounts, 45%-75% ethanol continuous circumfluence extraction, concentration and recovery ethanol, concentrated solution adds the water dilution that 1-1.5 doubly measures, add hydrochloric acid adjust pH 3-4, 1-3 doubly measures absolute ether and extracts 3 times (defat), more than acid liquid hydro-oxidation sodium is adjusted pH13, adding methylene chloride, 3 times (consumption is followed successively by 3 times of amounts in extraction, 2 times of amounts and 1 times of amount), combined dichloromethane extracting solution, reclaim dichloromethane, concentrated solution is dissolved in 65% ethanol, filter, reclaim ethanol to thick paste shape, vacuum drying is to Powdered, obtain Herba Sophorae alopecuroidis extract standby.
(2) the preparation of Radix Glycyrrhizae extract: extracting liquorice decoction pieces, the alcoholic solution reflux, extract, of use 5%-10% 3 times, each alcoholic solution consumption is 8-10 times, merge extractive liquid,, placement is got supernatant liquid filtering after spending the night, filtrate is concentrated into thick paste, and vacuum drying, to Powdered, obtains Radix Glycyrrhizae extract standby.
(3) get Herba Sophorae alopecuroidis extract 1-10 part and Radix Glycyrrhizae extract 1-5 part, adding distil water 5-10 part, stirs evenly, after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, and sterilizing, fill, in glass ampule, becomes injection.
(4) get Trypsin trypsin 0.2-2 part, Chymotrypsin 0.2-2 part, papain 0.1-1 part, adding distil water 2-10 part, dissolve after mix homogeneously, microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, and filtrate is spray dried to Powdered, under aseptic condition, be divided in cillin bottle, become injectable sterile powder.
(5) during clinical use, the injection of preparing with Radix Glycyrrhizae extract with Herba Sophorae alopecuroidis extract dissolves the sterilized powder of protease the breast perfusion that carries out milch cow after mixing.
The present invention develops according to the pathogeny of Chinese veterinarian's theory and mammitis of cow, has adjusting blood circulation of breast, inhibiting bacteria and diminishing inflammation and improve immunity of organisms effect.
Herba Sophorae alopecuroidis extract in prescription of the present invention has antipyretic-antalgic, inhibiting bacteria and diminishing inflammation, the effect of raising immunity; Radix Glycyrrhizae extract has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, the effect of relieving spasm to stop pain; Trypsin, Chymotrypsin and papain coupling degradable thrombosis, fibrin and slough, reduce serum viscosity and also can strengthen the phagocytosis of macrophage, can improve the microcirculation of focus generating region simultaneously, recovers dynamic equilibrium.All medicine compatibilities, combined effect make prescription there is heat-clearing and toxic substances removing, regulate blood circulation of breast, inhibiting bacteria and diminishing inflammation and raising immunity of organisms effect.
The present invention is composite by Chinese prescription and protease, is used for the treatment of mammitis of cow, has that onset speed is fast, toxic and side effects is low, a drug residue free, the feature that easy to use, bioavailability is high, is one to treat safely and effectively the compound filling agent of mammitis of cow.
The specific embodiment
With example, be explained the present invention below, it should be understood that example is for the present invention rather than limitation of the present invention are described.Scope of the present invention and core content are determined according to claims.
Embodiment 1
Treat a perfusate for mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 5kg, Radix Glycyrrhizae extract 2kg, trypsin 0.4kg, Chymotrypsin 0.2kg, papain 0.1kg.
Its preparation method is:
(1) sophora alopecuroide is ground into coarse powder, add the 60% ethanol continuous circumfluence extraction of 10 times, concentration and recovery ethanol, concentrated solution adds the water dilution of 1 times of amount, add hydrochloric acid adjust pH 3-4, absolute ether extracts 3 times, the absolute ether of each 2.5 times of amounts, more than acid liquid hydro-oxidation sodium is adjusted pH13, adding methylene chloride to extract (adds for 3 times the amount of dichloromethane to be respectively 3 times of amounts 3 times, 2 times of amounts, 2 times of amounts), combined dichloromethane extracting solution, reclaim dichloromethane, concentrated solution is dissolved in 65% ethanol, filter, reclaim ethanol to thick paste shape, vacuum drying is to Powdered, obtain Herba Sophorae alopecuroidis extract standby.
(2) extracting liquorice decoction pieces, the alcoholic solution reflux, extract, 3 times (each alcoholic solution consumption is respectively 8 times of amounts) with 5%, merge extractive liquid,, after placement is spent the night, get supernatant liquid filtering, filtrate is concentrated into thick paste, vacuum drying (temperature is 65～75 ℃), to Powdered, obtains Radix Glycyrrhizae extract standby.
(3) get Herba Sophorae alopecuroidis and extract Herba Sophorae alopecuroidis extract 5kg and Radix Glycyrrhizae extract 2kg, adding distil water 20kg, stirs evenly, after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, and sterilizing, fill becomes the injection of every dress 10ml.
(4) get trypsin 0.4kg, Chymotrypsin 0.2kg, papain 0.1kg, adding distil water 2kg mixed dissolution, after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, be spray dried to Powderedly, under aseptic condition, fill becomes the injectable sterile powder of every dress 1g.
(5) during clinical use, get a pheron sterilized powder, with the injection of two Chinese medicine extract, dissolve the breast perfusion that carries out milch cow after mixing.
Clinical practice test effect: 15 of milch cows that suffer from clinical type mammitis of cow for milk cattle cultivating base, Litong District, Wuzhong, Ningxia treatment, before treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node, milk is thin in flocculus, through clinical examination, is diagnosed as serosity mastitis.Method for the treatment of: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage 100%, after 7-12 days, 13 cow heads are cured, and cure rate is 86%.
Embodiment 2
Treat a perfusate for mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 8kg, Radix Glycyrrhizae extract 4kg, trypsin 0.5kg, Chymotrypsin 0.5kg, papain 0.2kg.
Its preparation method is as follows:
(1) Sophora Alopecuroides L. is ground into coarse powder, add the 45% ethanol continuous circumfluence extraction of 10 times, concentration and recovery ethanol, concentrated solution adds the water dilution of 1.5 times of amounts, add hydrochloric acid adjust pH 3-4, absolute ether extracts 3 times, the absolute ether of each 2.5 times of amounts, more than acid liquid hydro-oxidation sodium is adjusted pH13, adding methylene chloride to extract (adds for 3 times the amount of dichloromethane to be respectively 3 times of amounts 3 times, 2 times of amounts, 2 times of amounts), combined dichloromethane extracting solution, reclaim dichloromethane, concentrated solution is dissolved in 65% ethanol, filter, reclaim ethanol to thick paste shape, vacuum drying is to Powdered, obtain Herba Sophorae alopecuroidis extract standby.
(2) extracting liquorice decoction pieces, the alcoholic solution reflux, extract, 3 times (each alcoholic solution consumption is respectively 10 times of amounts) with 8%, merge extractive liquid,, after placement is spent the night, get supernatant liquid filtering, filtrate is concentrated into thick paste, vacuum drying (temperature is 65～75 ℃), to Powdered, obtains Radix Glycyrrhizae extract standby.
(3) get Herba Sophorae alopecuroidis and extract Herba Sophorae alopecuroidis extract 8kg and Radix Glycyrrhizae extract 4kg, adding distil water 20kg, stirs evenly, after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, and sterilizing, fill becomes the injection of every dress 10ml.
(4) get trypsin 0.5kg, Chymotrypsin 0.5kg, papain 0.2kg, adding distil water 2kg mixed dissolution, after microporous filter membrane (aperture 0.22 μ m-0.24 μ m) filters, be spray dried to Powderedly, under aseptic condition, fill becomes the injectable sterile powder of every dress 1g.
(5) during clinical use, get a pheron sterilized powder, with the injection of two Chinese medicine extract, dissolve the breast perfusion that carries out milch cow after mixing.
Clinical practice test effect: 17 of milch cows that suffer from clinical type mammitis of cow for milk cattle cultivating base, Litong District, Wuzhong, Ningxia treatment, before treatment, ill domestic animal symptom is that newborn matter is thin and amount is few, on inspection, somatic cell is 650,000/ml, other symptom is not obvious, through clinical examination, is diagnosed as recessive mastitis.Method for the treatment of: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage is after 100%, 7 day, and 16 cow heads are cured, and 200,000/ml is reduced in somatic cell, and cure rate is 94%.
Embodiment 3
Treat a perfusate for mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 1kg, Radix Glycyrrhizae extract 1kg, trypsin 0.2kg, Chymotrypsin 2kg, papain 0.8kg.
Preparation method is with embodiment 1.
Clinical practice test effect: 20 of milch cows that suffer from clinical type mammitis of cow for milk cattle cultivating district, Yinchuan of Ningxia Province city treatment, before treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node, milk is thin in flocculus, through clinical examination, is diagnosed as serosity mastitis.Method for the treatment of: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage 100%, after 7-10 days, 18 cow heads are cured, and cure rate is 90%.
Embodiment 4
Treat a perfusate for mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 10kg, Radix Glycyrrhizae extract 4kg, trypsin 2kg, Chymotrypsin 1kg, papain 0.6kg.
Preparation method is with embodiment 1.
Clinical practice test effect: suffer from 12 of the milch cows of clinical type mammitis of cow for Yinchuan of Ningxia Province milk cattle cultivating district treatment, before treatment, ill domestic animal symptom is that newborn matter is thin and amount is few, and other symptom is not obvious, is diagnosed as recessive mastitis through clinical examination.Method for the treatment of: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage is after 100%, 7 day, and 11 cow heads are cured, and cure rate is 91%.
Embodiment 5
Treat a perfusate for mammitis of cow, its prescription and weight ratio thereof are: Herba Sophorae alopecuroidis extract 6kg, Radix Glycyrrhizae extract 5kg, trypsin 1.2kg, Chymotrypsin 1.5kg, papain 1kg.
Preparation method is with embodiment 1.
Clinical practice test effect: 15 of milch cows that suffer from clinical type mammitis of cow for milk cattle cultivating base, Litong District, Wuzhong, Ningxia treatment, before treatment ill domestic animal symptom be that breast is red and swollen, heat, bitterly, the enlargement of breast superior gluteal lymph node, acinus, lactiferous ducts degeneration, the also toughness exudate that comes off, be diagnosed as mucus mastitis through clinical examination.Method for the treatment of: get the breast perfusion that said medicine is carried out ill milch cow, every day three times, continuous 5 days, ill milch cow symptom obviously alleviated, effective percentage is after 100%, 7 day, and 12 cow heads are cured, and cure rate is 80%.
Claims (8)
1. treat a perfusate for mammitis of cow, it is characterized in that the main pharmacodynamics of this infusion liquid consists of the raw material of following weight proportioning:
Herba Sophorae alopecuroidis extract 1-10 part,
Radix Glycyrrhizae extract 1-5 part,
Trypsin 0.2-2 part,
Chymotrypsin 0.2-2 part,
Papain 0.1-1 part;
Above-mentioned Herba Sophorae alopecuroidis extract adopts following method to obtain: by sophora alopecuroide or Sophora Alopecuroides L. coarse powder 45%-75% ethanol continuous circumfluence extraction, concentration and recovery ethanol, concentrated solution thin up, adjust pH 3-4, add absolute ether and extract, gained acid liquid is with adjusting PH with base more than 13, and extraction adds methylene chloride, reclaim dichloromethane, concentrated solution is dissolved in 65% ethanol, filters, and reclaims ethanol to thick paste shape, vacuum drying, to Powdered, obtains Herba Sophorae alopecuroidis extract;
Above-mentioned Radix Glycyrrhizae extract adopts following method to obtain: the alcoholic solution reflux, extract, by licorice piece with 5%-10%, and the 8-10 that alcoholic solution consumption is licorice piece times, after placement is spent the night, get supernatant liquid filtering, filtrate is concentrated into thick paste, and vacuum drying, to Powdered, obtains Radix Glycyrrhizae extract.
2. according to the perfusate for the treatment of mammitis of cow claimed in claim 1, it is characterized in that ethanol consumption in above-mentioned ethanol continuous backflow is sophora alopecuroide or Sophora Alopecuroides L. coarse powder 10 times.
3. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 1, it is characterized in that: in above-mentioned Extraction Process of Sophora alopecuroides, concentrated solution adds the water dilution that 1-1.5 doubly measures.
4. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 1, it is characterized in that: in above-mentioned Extraction Process of Sophora alopecuroides, with absolute ether, extract 3 times the absolute ether of at every turn doubly measuring with 1-3.
5. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 1, it is characterized in that: in above-mentioned Extraction Process of Sophora alopecuroides, use dichloromethane extraction 3 times, consumption is followed successively by 3 times of amounts, 2 times of amounts and 1 times of amount.
6. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 1, its technical process comprises:
A. by the Herba Sophorae alopecuroidis extract of formula ratio and Radix Glycyrrhizae extract adding distil water, stir evenly, sterilizing after filtering with microporous membrane, fill obtains injection;
B. the trypsin of formula ratio, Chymotrypsin and papain are dissolved with distilled water, after mix homogeneously, filtering with microporous membrane, filtrate is spray dried to Powdered, and under aseptic condition, packing obtains injectable sterile powder.
7. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 6, the consumption that it is characterized in that above-mentioned Herba Sophorae alopecuroidis extract, Radix Glycyrrhizae extract and distilled water is 1-10 part, 1-5 part and 5-10 part.
8. according to the preparation method of the perfusate for the treatment of mammitis of cow claimed in claim 6, the consumption that it is characterized in that above-mentioned trypsin, Chymotrypsin, papain and distilled water is 0.2-2 part, 0.2-2 part, 0.1-1 part and 2-10 part.
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| CN103142683B (en) * | 2013-03-12 | 2015-09-09 | 广东海纳川生物科技股份有限公司 | Be used for the treatment of Chinese medicinal perfusion liquid containing Herba Sophorae alopecuroidis total alkali of bovine mastitis and endometritis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406515A (en) * | 2008-12-02 | 2009-04-15 | 黑龙江省汇丰动物保健品有限公司 | Breast perfusate for treating mammitis of milk cattle and preparation thereof |
| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406515A (en) * | 2008-12-02 | 2009-04-15 | 黑龙江省汇丰动物保健品有限公司 | Breast perfusate for treating mammitis of milk cattle and preparation thereof |
| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
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