CN101439044B - Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application in preparing medicine - Google Patents
Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application in preparing medicine Download PDFInfo
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- CN101439044B CN101439044B CN2008102374333A CN200810237433A CN101439044B CN 101439044 B CN101439044 B CN 101439044B CN 2008102374333 A CN2008102374333 A CN 2008102374333A CN 200810237433 A CN200810237433 A CN 200810237433A CN 101439044 B CN101439044 B CN 101439044B
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Abstract
The invention belongs to the technical field of animal remedy preparation and in particular relates to a pharmaceutical composition for curing dairy cow mastitis and a preparation method and a usage of the pharmaceutical composition. The remedy comes into being by mixing carbomer-940, povidone iodine, hydrocortisone, potash iodate, propylene glycol or glycerol, sodium hydroxide and purified water. The povidone iodine in the preparation has great sterilizing power, no odor or stimulation or sensitization and low toxicity and leads to no residuals which are formed in milk and harmful to human body, no withdrawal period is required during the course of medication, and no milk drinking stop is required; a prepared gel preparation is injected into breasts, a relatively high drug concentration can be achieved in the breasts in a short time, and the treatment cycle is short. Results of clinical trials show that the cure rate of recessive mastitis of the diary cow is up to 86.43 percent, and the effective rate is up to100 percent; and the cure rate of clinical mastitis of the diary cow is up to 78.03 percent, and the effective rate is up to 93.75 percent.
Description
Technical field
The invention belongs to technical field of animal remedy preparation, specifically belong to a kind of compound povidone iodine gel for the treatment of bovine mastitis and preparation method thereof and application.
Background technology
Mastitis are common, the most multiple a kind of mastopathy of milch cow, are common in high yield cow lactogenic initial stage or milk production higher period, and mastitis not only influence the milk quality, and reduce milk yield, have caused serious harm for the development of milk industry.Bovine mastitis is mainly caused by pathogen such as staphylococcus aureus, escherichia coli, streptococcus dysgalactiae, streptococcus agalactiae, pneumobacilluses.Adopted antibiotic or treatment by Chinese herbs, yet antibiotic therapy easily causes drug-resistance of bacteria, its effect of treatment by Chinese herbs is slow and fail to make this problem to be solved at all in the past.On the basis that the present invention is intended to address the above problem, produce and apply the novel veterinary drug of a kind of treatment bovine mastitis.
Povidone iodine in the preparation of the present invention is to be the nonionic povidone iodine that main sterilization composition is made with iodine, is to use the most extensive, safest antibiosis and sterilization agent at present.China and countries in the world pharmacopeia have all been taken in interior.It contains various active iodines, and the effect of powerful mastitis-resisting pathogen is arranged, and is to treat one of very promising medicine of mastitis now.Povidone iodine is a kind of new and effective, wide-spectrum bactericide (Zhou Yan etc., efficient germicide-povidone iodine, Journal of Occupational Health andDamage, 2004,19 (2): 144), be a kind of unbodied soluble complex that polyvinylpyrrolidone homopolymer (PVP) combines with iodine and forms, its available iodine content is 9%～12%.Polyvinylpyrrolidone is as the carrier of iodine, and penetrable bacterial membrane makes povidone iodine enter thalline, discharges the diatomic free-iodine, makes sulfohydrate in the cell, protein, material oxidation such as enzyme and vitamin and instantaneous kill bacteria.At present, the product of povidone iodine has been applied in above the bovine mastitis treatment, as the nipple appropriative disinfector---and activating the iodine powder, is to adopt U.S.'s state-of-the-art technology, veterinary drug novel formulation through developing has for many years been filled up the blank of domestic mammilla of milk cattle appropriative disinfector product.Passing through the strictness audit of veterinary drug evaluation committee of the Ministry of Agriculture in 2004, obtained new veterinary drug certificate of national three classes and authentication code, is domestic unique mammilla of milk cattle appropriative disinfector through state approval.Cow breast soak (betagen solution) is taken in " Chinese veterinary drug allusion quotation " 2000 editions (one one), said preparation can effectively be killed staphylococcus aureus, streptococcus agalactiae, streptococcus dysgalactiae, streptococcus uberis and escherichia coli etc., by continuous release free-iodine, destroy the thalline metabolism, and make antibacterial etc. microorganism deactivated.Be a kind of germ killing drugs of high-efficiency low-toxicity, antibacterial, virus and fungus are all had good killing action, have disinfective action.But this medicine must be before and after milk the whole surface of the contacted breast of covering and rubber cushion and milk, soak and at least 2/3 degree of depth of breast, be not easy operation in the production practices, in the winter time,, easily cause cracked nipple or cold injury in the exsiccant use in winter of cold.
Hydrocortisone in the preparation of the present invention (claiming hydrocortisone again) belongs to adrenal gland's glucocorticoid, has stronger antiinflammatory, antitoxic action.Simultaneously, the life-span of hydrocortisone scalable cattle and sheep lactotroph, scientifically utilize hydrocortisone to be expected to prolong the lactation period of cattle and sheep, improve milk yield (Russia's " scientific information ").
The present invention is that forefathers research and develop on the basis of treatment bovine mastitis, has both added antibiosis and sterilization agent-povidone iodine preferably in the compound preparation, has added the strong hydrocortisone of antiinflammation again; Simultaneously, this medicine is the gel dosage form, and itself preparation technology is simple, and production cost is low, and characteristics such as easy to operate are easily accepted by vast milk cattle cultivating family during medication, are convenient to apply in middle-size and small-size cattle farm.
Have not yet to see the report of the preparation method of the compound povidone iodine gel for the treatment of bovine mastitis.
Summary of the invention
The object of the invention is to overcome the defective that traditional therapy exists, and a kind of convenient drug administration is provided, and is efficient, safety, the preparation method and the application thereof of the compound povidone iodine gel that is used for the treatment of bovine mastitis that has no side effect.
The present invention is achieved in that
A kind of compound povidone iodine gel preparation for the treatment of bovine mastitis, in parts by weight, its component is as follows:
Carbomer-940 0.1～2 part;
0.2～6 part of povidone iodine;
1～10 part of hydrocortisone;
0.05～0.1 part of sodium hydroxide;
0.1～0.5 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts;
Preparation according to the following steps:
(1) carbomer is added little water and stir, fully swelling;
(2) sodium hydroxide is added in the carbomer of step (1), obtain gel-type vehicle;
(3) povidone iodine is joined in the gel-type vehicle of step (2), stir;
(4) with little water potassium iodate is made solution and will add in the lump in the product of step (3) gained behind hydrocortisone and propylene glycol or the glycerol mixing;
(5) keep the skin wet and to formula ratio, stir, be finished product.
Preferably, preparation of the present invention, in parts by weight, its component is as follows:
Carbomer-940 0.2～1 part;
1～5 part of povidone iodine;
2～8 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
Preferably, preparation of the present invention, in parts by weight, its component is as follows:
Carbomer-940 0.4～0.8 part;
2～4 parts of povidone iodine;
3～7 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
Preferably, preparation of the present invention, in parts by weight, its component is as follows:
Carbomer-940 0.5～0.7 part;
3～3.75 parts of povidone iodine;
4～6 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
In the present invention, preferred protective agent is selected from glycerol, not only economy but also effective.
Preparation method of the present invention is as follows:
In parts by weight, its component is as follows:
Carbomer-940 0.1～2 part;
0.2～6 part of povidone iodine;
1～10 part of hydrocortisone;
0.05～0.1 part of sodium hydroxide;
0.1～0.5 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts;
Press formula ratio and the following step
(1) carbomer is added little water and stir, fully swelling;
(2) sodium hydroxide is added in the carbomer of step (1), obtain gel-type vehicle;
(3) povidone iodine is joined in the gel-type vehicle of step (2), stir;
(4) with little water potassium iodate is made solution and will add in the lump in the product of step (3) gained behind hydrocortisone and propylene glycol or the glycerol mixing;
(5) keep the skin wet and to formula ratio, stir, be finished product.
The compound povidone iodine gel of applicant's preparation shows that through zoopery the treatment bovine mastitis is had the good clinical effect.
Of the present inventionly usefully be:
1, povidone iodine has strong, tasteless, non-stimulated, the no sensitization of sterilizing power in the compound preparation of the present invention, toxicity is low; Hydrocortisone has stronger antiinflammatory, antitoxic action in the preparation, is used to replace traditional antibiotic therapy mammitis of cow, can not form harmful residually in milk, does not have withdrawal time during the medication, need not to abandon milk;
2, the gel of making carries out injecting administration in the breast, reaches higher drug level in the short time in mammary gland, and treatment cycle is short, and is easy to operate during medication;
3, through clinic trial: the bovine subclinical mastitis cure rate is 86.43%, and effective percentage is 100%; Milch cow clinic mastitis cure rate is more than 78.03%, and effective percentage is more than 93.75%.
To more detailed description of the present invention referring to the embodiment part.
The specific embodiment
Embodiment 1
The addition in kind of preparation 100Kg compound povidone iodine gel finished product component is as follows:
Carbomer-940 0.1Kg
4% povidone iodine 0.2Kg
Hydrocortisone 1Kg
Sodium hydroxide 0.05Kg
Potassium iodate 0.1Kg
Propylene glycol 5Kg
Add pure moisture 93.55Kg.
Preparation according to the following steps:
Press formula ratio:
(1) carbomer is added little water and stir, fully swelling;
(2) sodium hydroxide is added in the carbomer of step (1), obtain gel-type vehicle;
(3) povidone iodine is joined in the gel-type vehicle that step (2) obtains, stir;
(4) with little water potassium iodate is made solution and will add in the lump behind hydrocortisone and the propylene glycol mixing in the product of step (3) gained;
(5) be finished product after the mixing of interpolation pure water stirs evenly.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 0.5g, 4% povidone iodine 10g,, hydrocortisone 5g, sodium hydroxide 0.25g, potassium iodate 0.5g, propylene glycol 25g, every bottle of gel gross weight 500g.
Embodiment 2
The step described according to embodiment 1, the addition in kind of each component for preparing the 100Kg compound povidone iodine gel in the present embodiment is as follows:
Carbomer-940 0.2Kg
4% povidone iodine 1Kg
Hydrocortisone 2Kg
Sodium hydroxide 0.06Kg
Potassium iodate 0.2Kg
Propylene glycol 10Kg
Add pure moisture 86.54Kg.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 1g, 4% povidone iodine 5g, hydrocortisone 10g, sodium hydroxide 0.3g, potassium iodate 1.25g, propylene glycol 50g,, every bottle of gel gross weight 500g.
Embodiment 3
The step described according to embodiment 1, the addition in kind of each component for preparing the 100Kg compound povidone iodine gel in the present embodiment is as follows:
Carbomer-940 0.4Kg
4% povidone iodine 2Kg
Hydrocortisone 3Kg
Sodium hydroxide 0.06Kg
Potassium iodate 0.3Kg
Glycerol 10Kg
Add pure moisture 84.24Kg.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 2g, 4% povidone iodine 10g, hydrocortisone 15g, sodium hydroxide 0.3g, potassium iodate 1.5g, glycerol 50g,, every bottle of gel gross weight 500g.
Embodiment 4
The step described according to embodiment 1, the addition in kind of each component for preparing the 100Kg compound povidone iodine gel in the present embodiment is as follows:
Carbomer-940 0.5Kg
4% povidone iodine 3Kg
Hydrocortisone 4Kg
Sodium hydroxide 0.07Kg
Potassium iodate 0.25Kg
Glycerol 15Kg
Add pure moisture 77.18Kg.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 2.5g, 4% povidone iodine 15g, hydrocortisone 20g, sodium hydroxide 0.35g, potassium iodate 1g, glycerol 75g,, every bottle of gel gross weight 500g.
Embodiment 5
The step described according to embodiment 1, the addition in kind of each component for preparing the 100Kg compound povidone iodine gel in the present embodiment is as follows:
Carbomer-940 0.5Kg
4% povidone iodine 4Kg
Hydrocortisone 6Kg
Sodium hydroxide 0.08Kg
Potassium iodate 0.25Kg
Glycerol 15Kg
Add pure moisture 74.17Kg.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 2.5g, 4% povidone iodine 20g, hydrocortisone 30g, sodium hydroxide 0.4g, potassium iodate 1g, glycerol 75g,, every bottle of gel gross weight 500g.
Embodiment 6
The step described according to embodiment 1, the addition in kind of each component for preparing the 100Kg compound povidone iodine gel in the present embodiment is as follows:
Carbomer-940 0.5Kg
4% povidone iodine 3.75Kg
Hydrocortisone 5Kg
Sodium hydroxide 0.075Kg
Potassium iodate 0.25Kg
Glycerol 10Kg
Add pure moisture 80.425Kg.
Every bottle of gel 500g in the gel composite finished product that present embodiment is produced, every bottle of gel component content: carbomer-940 be 2.5g, 4% povidone iodine 18.75g, hydrocortisone 25g, sodium hydroxide 0.375g, potassium iodate 1g, glycerol 50g,, every bottle of gel gross weight 500g.
Embodiment 7 (animal experiment example)
Trial drug: come from the synthetic compound povidone iodine gel complex of the applicant, (lot number 081010) keeps in Dark Place
Control drug: penicillin (Jin He group in the Inner Mongol produces, lot number 071005); Streptomycin (Bei'an, Heilongjiang Province pharmaceutical factory, lot number 070502)
The case source:
Test used milch cow from 10 tame pastures such as Wuhan City, Hubei Province friend's friendly dairy industry company experiment pasture, the safe cattle farms of thing lake, Wuhan City China.Clinical type mastitis are defined as clinical type mastitis according to clinical symptoms.
Diagnostic criteria:
Milk has flocculus, grumeleuse, is water sample sometimes, and mammary gland slightly generates heat, pain (or nothing), and lactation amount reduces; For severe patient, acute swelling appears, and palpation has lump or tenderness, or fervescence occurs, the depressed General Symptoms that waits of spirit.
Grouping: adopt the random packet test
Treatment group: 64 ill breast districts;
Positive controls: totally 114 ill breasts are distinguished.Wherein 54 breasts of mycillin are distinguished, logical 60 the breast districts of lactogenic;
Blank group: 40 ill breast districts.
Recovery from illness: breast redness, burning pain, the hard disappearance, the milk perusal is normal, and milk yield gos up;
Effectively: breast redness, burning pain alleviate, and milk does not have lump or a small amount of lump is arranged, milk yield go up or fully recovered 7 days after recidivist again;
Invalid: the breast red and swollen heat pain is hard, does not have obviously improvement or more serious, and milk is unusual, and milk yield descends.
The zooperal result of present embodiment is as shown in the table as a result:
Table 1 the present invention and penicillin, streptomycin and blank are to the curative effect of the clinical type mastitis of milch cow
Analyze the significance of difference that adopts t check analysis treatment group of the present invention and positive controls and blank group curative effect.
The treatment group to the cure rate of subclinical mastitis treatment be 78.03%, total effective rate is 93.75%, and is all high than positive control penicillin and streptomycin group, the logical group of lactogenic.Through the t check, treatment group cure rate is significantly higher than positive control mycillin group, the logical group of lactogenic, shows that the effect of compound povidone iodine gel group treatment subclinical mastitis significantly is better than antibiotic.
Using method of the present invention is: adopt the lactogenesis pin that compound gel is sent into the mammary gland tissue deep, and a 10g, once-a-day, ten days is a course of treatment.
Embodiment 8 (animal experiment example)
Trial drug: come from the synthetic compound povidone iodine gel of the applicant, (lot number 081011) keeps in Dark Place
Control drug: penicillin (Jin He group in the Inner Mongol produces, lot number 071005); Streptomycin (Bei'an, Heilongjiang Province pharmaceutical factory, lot number 070502); Lactogenic logical (Pfizer Inc. Belgium produces, No. 15, (2006) outer veterinary drug card word)
The case source:
Test used milch cow from 10 tame pastures such as Wuhan City, Hubei Province friend's friendly dairy industry company experiment pasture, the safe cattle farms of thing lake, Wuhan City China.Clinical type mastitis are defined as clinical type mastitis according to clinical symptoms.
Diagnostic criteria:
Employing California mastitis detection method (Xiao Lianming. etc., bovine mastitis diagnostic method progress [J], Chinese cattle industry science, 2007) detection diagnosis of milk cow subclinical mastitis.
Grouping: adopt the random packet test
Treatment group: ill 140 breast districts;
Positive controls: ill 106 breast districts;
Blank group: ill 100 breast districts.
Cure: promptly negative, the fluid properties no change of the mixed liquor of milk and diagnosticum,
Effectively: promptly weak positive, slight viscosity appears in mixed liquor,
Invalid: promptly positive, obvious viscosity appears in mixed liquor,
The zooperal result of present embodiment is as shown in the table as a result:
Table 2 the present invention and penicillin, streptomycin and blank are to the curative effect of the latent type mastitis of milch cow
| ? | Breast district (individual) | Handle | Dosage and frequency | Cure | Effectively | Invalid | Cure rate | Total effective rate |
| The treatment group | 140? | Inject in the nipple of the present invention | 10g/ time 1 time/day | 121? | 19? | 0? | 86.43％? | 100％? |
| Positive controls | 106? | Benzathine penicillin | Penicillin 3,200,000 IU/ time 2 times/day | 49? | 21? | 36? | 46.23％? | 66.04％? |
| The blank group | 100? | Do not handle | Not administration | 0? | 0? | 100? | 0％? | 0％? |
Analyze the significance of difference that adopts t check analysis treatment group of the present invention and positive controls and blank group curative effect.
The treatment group to the cure rate of subclinical mastitis treatment be 86.43%, total effective rate is 100%, positive controls cure rate 46.23%, total effective rate are 66.04%, blank group cure rate, effective percentage are 0%, and treatment group cure rate, total effective rate are all than positive controls, blank group height; And treatment group and positive controls, blank group difference be (P＜0.01) extremely significantly, shows that the effect of compound povidone iodine gel group treatment subclinical mastitis significantly is better than antibiotic.
Using method of the present invention is: adopt milch cow lactogenesis pin that compound gel is sent into the mammary gland tissue deep, and a 10g, once-a-day, ten days is a course of treatment.
Embodiment 8 (animal experiment example)
Trial drug: three batches of the synthetic compound povidone iodine gels of the applicant, (lot number 081012,081013,081014) keeps in Dark Place
EXPERIMENTAL DESIGN: test is made as three groups, and hydrocortisone content is 5g/100g in above-mentioned three reply side's povidone iodine gels, and the content of povidone iodine is followed successively by 2.75g/100g, 3.75g/100g, 4.75g/100g in the lot number 081012,081013,081014.Adopt three reply side's povidone iodine gels to be used for treating the milk cow recessive mastitis respectively, observe therapeutic effect.
The case source:
Test used milch cow from 10 tame pastures such as Wuhan City, Hubei Province friend's friendly dairy industry company experiment pasture, the safe cattle farms of thing lake, Wuhan City China.Clinical type mastitis are defined as clinical type mastitis according to clinical symptoms.
Diagnostic criteria:
Employing California mastitis detection method (Xiao Lianming. etc., bovine mastitis diagnostic method progress [J], Chinese cattle industry science, 2007) detection diagnosis of milk cow subclinical mastitis.
Cure: promptly negative, the fluid properties no change of the mixed liquor of milk and diagnosticum,
Effectively: promptly weak positive, slight viscosity appears in mixed liquor,
Invalid: promptly positive, obvious viscosity appears in mixed liquor,
The zooperal result of present embodiment is as shown in the table as a result:
Analyze three reply side's povidone iodine gels to milk cow recessive mastitis curative effect.
As can be seen from the above table, the cure rate of the 081013 pair of subclinical mastitis of lot number treatment is 86.67%, total effective rate is 100%, is higher than the cure rate and the effective percentage of other two batches of gels.Check through t, cure rate and 081013,081,014 2 groups of significant differences of lot number (P＞0.05) of 081013 pair of subclinical mastitis treatment of lot number, show in compound povidone iodine gel, hydrocortisone content (5g/100g) one regularly, povidone iodine content at 3.75g/100g to treatment milk cow recessive mammary gland best results.
Using method of the present invention is: adopt milch cow lactogenesis pin that compound gel is sent into the mammary gland tissue deep, and a 10g, once-a-day, ten days is a course of treatment.
Embodiment 9 (animal experiment example)
Trial drug: three batches of the synthetic compound povidone iodine gels of the applicant, (lot number 081015,081016,081017) keeps in Dark Place
EXPERIMENTAL DESIGN: test is made as three groups, and povidone iodine content is 3.75g/100g in above-mentioned three reply side's povidone iodine gels, and the content of povidone iodine is followed successively by 3g/100g, 5g/100g, 7g/100g in the lot number 081015,081016,081017.Adopt three reply side's povidone iodine gels to be used for treating the milk cow recessive mastitis respectively, observe therapeutic effect.
The case source:
Test used milch cow from 10 tame pastures such as Wuhan City, Hubei Province friend's friendly dairy industry company experiment pasture, the safe cattle farms of thing lake, Wuhan City China.Clinical type mastitis are defined as clinical type mastitis according to clinical symptoms.
Diagnostic criteria:
Employing California mastitis detection method (Xiao Lianming. etc., bovine mastitis diagnostic method progress [J], Chinese cattle industry science, 2007) detection diagnosis of milk cow subclinical mastitis.
Cure: promptly negative, the fluid properties no change of the mixed liquor of milk and diagnosticum,
Effectively: promptly weak positive, slight viscosity appears in mixed liquor,
Invalid: promptly positive, obvious viscosity appears in mixed liquor,
The zooperal result of present embodiment is as shown in the table as a result:
Analyze three reply side's povidone iodine gels to milk cow recessive mastitis curative effect.
As can be seen from the above table, the cure rate of the 081016 pair of subclinical mastitis of lot number treatment is 85%, total effective rate is 100%, is higher than the cure rate and the effective percentage of other two batches of gels.Check through t, cure rate and 081015,081,017 2 groups of significant differences of lot number (P＞0.05) of 081016 pair of subclinical mastitis treatment of lot number, show in compound povidone iodine gel, povidone iodine content (3.75g/100g) one regularly, hydrocortisone content when 5g/100g to treatment milk cow recessive mammary gland best results.
Using method of the present invention is: adopt milch cow lactogenesis pin that compound gel is sent into the mammary gland tissue deep, and a 10g, once-a-day, ten days is a course of treatment.
Claims (7)
1. compound povidone iodine gel preparation for the treatment of bovine mastitis, in parts by weight, its component is as follows:
Carbomer-940 0.1～2 part;
0.2～6 part of povidone iodine;
1～10 part of hydrocortisone;
0.05～0.1 part of sodium hydroxide;
0.1～0.5 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts;
Preparation according to the following steps:
(1) carbomer is added little water and stir, fully swelling;
(2) sodium hydroxide is added in the carbomer-940 of step (1), obtain gel-type vehicle;
(3) povidone iodine is joined in the gel-type vehicle of step (2), stir;
(4) with little water potassium iodate is made solution and will add in the lump in the product of step (3) gained behind hydrocortisone and propylene glycol or the glycerol mixing;
(5) keep the skin wet and to formula ratio, stir, be finished product.
2. preparation according to claim 1, in parts by weight, its component is as follows:
Carbomer-940 0.2～1 part;
1～5 part of povidone iodine;
2～8 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
3. preparation according to claim 1, in parts by weight, its component is as follows:
Carbomer-940 0.4～0.8 part;
2～4 parts of povidone iodine;
3～7 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
4. preparation according to claim 1, in parts by weight, its component is as follows:
Carbomer-940 0.5～0.7 part;
3～3.75 parts of povidone iodine;
4～6 parts of hydrocortisone;
0.06～0.08 part of sodium hydroxide;
0.2～0.4 part of potassium iodate;
5～15 parts of protective agent propylene glycol or glycerol;
Keep the skin wet to 100 parts.
5. the described preparation of claim 1, wherein said protective agent is a glycerol.
6. the method for the compound povidone iodine gel of the described treatment bovine mastitis of preparation claim 1 is characterized in that, presses formula ratio and the following step
(1) carbomer is added little water and stir, fully swelling;
(2) sodium hydroxide is added in the carbomer-940 of step (1), obtain gel-type vehicle;
(3) povidone iodine is joined in the gel-type vehicle of step (2), stir;
(4) with little water potassium iodate is made solution and will add in the lump in the product of step (3) gained behind hydrocortisone and propylene glycol or the glycerol mixing;
(5) keep the skin wet and to formula ratio, stir, be finished product.
7. the application of the described compound povidone iodine gel preparation of claim 1 in preparation bovine mastitis pharmaceutical composition.
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| CN2008102374333A CN101439044B (en) | 2008-12-26 | 2008-12-26 | Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application in preparing medicine |
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| CN101804069A (en) * | 2010-05-17 | 2010-08-18 | 天津市大康科技有限公司 | Concentrated disinfectant for nipples of dairy cows |
| CN102552104A (en) * | 2010-12-18 | 2012-07-11 | 广西壮族自治区花红药业股份有限公司 | Gel for treating vaginitis and preparation method of gel |
| EP3313183B1 (en) | 2015-06-23 | 2020-07-08 | Ecolab USA Inc. | An aqueous antimicrobial film-forming composition for teat treatment by spray application |
| EP3603645A1 (en) | 2018-07-30 | 2020-02-05 | Virbac | Novel use of glucocorticoids for the treatment of epithelial microbial infections of a fluid containing organ with a natural exterior orifice in mammals |
| CN110464738A (en) * | 2019-09-26 | 2019-11-19 | 成都科宏达科技有限公司 | A kind of compound disinfectant preventing cow breast disease |
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2008
- 2008-12-26 CN CN2008102374333A patent/CN101439044B/en not_active Expired - Fee Related
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