CN1965976A - Chinese medicinal composition for preventing and treating cow mastitis - Google Patents
Chinese medicinal composition for preventing and treating cow mastitis Download PDFInfo
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- CN1965976A CN1965976A CN 200610150996 CN200610150996A CN1965976A CN 1965976 A CN1965976 A CN 1965976A CN 200610150996 CN200610150996 CN 200610150996 CN 200610150996 A CN200610150996 A CN 200610150996A CN 1965976 A CN1965976 A CN 1965976A
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Abstract
The invention discloses a Chinese medicinal composition for treating cow mastitis which is prepared from the following raw materials (by weight portion): dandehon herb 4-6 parts, honeysuckle flower 3-6 parts, Philippine violet herb 2-6 parts, Chinese angelica root 4-6 parts, pericarpium trichosanthis 3-7 parts, arctium fruit 3-6 parts, rhizome of Sichuan lovage 2-5 parts, green tangerine orange peel 3-7 part, baikal skullcap root 4-6 parts and capsule of weeping forsythia 2-6 parts.
Description
One, technical field
What the present invention relates to is Chinese medicine for animals, particularly be a kind of Chinese medicine composition of preventing and treating mammitis of cow.
Two, background technology
Mammitis of cow (Bovine mastitis) is that mammary gland is subjected to physics, chemistry, microorganism and stimulates a kind of inflammatory that is taken place to change.Clinical pathology shows as: somatic cell content increases in the milk, and mammary gland tissue generation physical change is commonly encountered diseases, the frequently-occurring disease of milch cow.Mammitis of cow not only makes the milk yield of milch cow descend, and the quality of reduction milk, shorten the service life of milch cow, increase the cost of reserve milch cow, increase extra labor expenses, medicine spending and veterinary's service fee, prolong post-partum estrus and pregnant time, cause enormous economic loss to dairy.
At present, the method about the control mammitis of cow mainly is antibiotherapy and herbal treatment.Antibiotherapy is detrimental to health because long-term, a large amount of administrations causes the generation of a large amount of antibiotic remains in Ruzhong and bacterial drug resistance.The used dosage form of Chinese herb prevention mammitis of cow is comparatively single, mainly is powder and decoct, administration inconvenience.
Three, summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition of preventing and treating mammitis of cow, be used for the treatment of bacterial bovine subclinical mastitis and clinic mastitis.
Another object of the present invention is that above-mentioned composition is made unguentum, makes things convenient for administration.
The present invention adopts following technical proposals to be achieved: according to the pathological characters of Chinese veterinarian's theory and mammitis of cow, the Chinese medicine composition of development control mammitis of cow, its prescription should have heat-clearing and toxic substances removing, anti-inflammation, restore menstrual flow and invigorate blood circulation, anti-inflammatory analgetic, the effect of active lactogenesis determines that in conjunction with Chinese medical theory the Chinese medicine composition among the present invention made by following parts by weight proportion raw material: Herba Taraxaci 4-6 part, Flos Lonicerae 3-6 part, Herba Violae 2-6 part, Radix Angelicae Sinensis 4-6 part, Fructus Trichosanthis 3-7 part, Fructus Arctii 3-6 part, Rhizoma Chuanxiong 2-5 part, Pericarpium Citri Reticulatae Viride 3-7 part, Radix Scutellariae 4-6 part, Fructus Forsythiae 2-6 part.Herba Taraxaci, Flos Lonicerae are the effect that principal agent has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, wind-heat dissipating in the side; Fructus Forsythiae, Herba Violae, Radix Scutellariae have removing heat from blood, antibacterial, antiphlogistic effect, and Pericarpium Citri Reticulatae Viride is regulated the flow of vital energy, removing food stagnancyization stagnates, and is accessory drugs altogether; Chinese angelica blood supplementing is invigorated blood circulation, pain relieving, with the Rhizoma Chuanxiong blood stasis dispersing and deswelling that matches be adjuvant drug; Fructus Arctii, Fructus Trichosanthis be for making, and all medicines are in harmonious proportion compatibility, combined effect, makes that its prescription has heat-clearing and toxic substances removing, anti-inflammation, restores menstrual flow and invigorates blood circulation, the effect of anti-inflammatory analgetic, active lactogenesis.
Above-mentioned Chinese medicine composition can be made into any dosage form that Zoopharmacy allows after adding adjuvant, as unguentum, injection, powder, decoct.
Emulsifiable paste matrix in the unguentum is by stearic acid, glyceryl monostearate, vaseline, ethyl hydroxybenzoate, azone, and triethanolamine, potassium hydroxide, Borax, potassium sorbate, glycerol, liquid paraffin, distilled water constitute, and the azone in the component is the transdermal penetrating agent.
The concrete preparation method of unguentum: earlier Chinese medicine composition is taken by weighing by formula ratio, produce traditional Chinese medicine composition extract liquid with decoction and alcohol sedimentation technique; Take by weighing stearic acid, glyceryl monostearate, vaseline, ethyl hydroxybenzoate, azone Hybrid Heating by the formula ratio of making the used emulsifiable paste matrix of unguentum and make its fusing fusion back form the oil phase component mixed liquor, 82 ± 2 ℃ of water bath heat preservations are standby; The potassium hydroxide, triethanolamine, potassium sorbate, the Borax that take by weighing the emulsifiable paste matrix formula ratio mix with the glycerol, the liquid paraffin that add formula ratio behind the dissolved in distilled water, the adding traditional Chinese medicine composition extract liquid is heated to and boils behind the mixing, when temperature is 82 ± 2 ℃, join in the oil phase component mixed liquor, promptly get unguentum after the condensation.
Other dosage form is preparation according to a conventional method all, as injection, powder, decoct.
The present invention also can be used for treating the mastitis of other ruminant animal.
Effect of the present invention and advantage:
1, compositions of the present invention is a pure Chinese medicinal preparation, and reasonable recipe has no side effect, raw material be easy to get and cost low.
2, the unguentum of making by the compositions among the present invention, by adding the transdermal penetrating agent in the external coated administration of breast, make Chinese medicine ingredients easily see through skin of mammary gland, in mammary gland, reach higher drug level, promptly changed administering mode, avoided excessive again, produced the drawback that stress brought of liver first-pass effect, gastrointestinal toxicity and body because of oral administration dosage, drug effect is reliable, convenient drug administration.
3, its preparation is used for the treatment of bovine subclinical mastitis and clinic mastitis, and through clinic trial, tracing observation record, its latent mammitis cure rate is more than 80%, and effective percentage is more than 86%; The clinic mastitis cure rate is more than 70%, and effective percentage is more than 82%.
Four, the specific embodiment
Embodiment 1:
(1), the preparation of traditional Chinese medicine composition extract liquid and unguentum
1, prescription is formed: a kind of Chinese medicine composition of preventing and treating mammitis of cow is made by following parts by weight proportion raw material: Herba Taraxaci 5 parts of (150g), Flos Lonicerae 5 parts of (150g), Herba Violae 5 parts of (150g), Radix Angelicae Sinensis 5 parts of (150g), Fructus Trichosanthis 5 parts of (150g), Fructus Arctii 5 parts of (150g), Rhizoma Chuanxiong 4 parts of (120g), Pericarpium Citri Reticulatae Viride 4 parts of (120g), Radix Scutellariae 4 parts of (120g), 4 parts of Fructus Forsythiaes (120g).
2, the preparation of traditional Chinese medicine composition extract liquid: after each component takes by weighing by formula ratio, added 10 times of water logging bubbles 12 hours, decoct twice, decocted 1 hour for the first time, decocted 45 minutes for the second time, twice medicinal liquid merge filter after, add ethanol (95%) and make and contain the alcohol amount and reach 70% (volume ratio), behind the mixing, 4 ℃ leave standstill centrifugal concentrating after 12 hours, and then add ethanol (95%) and make and contain the alcohol amount and reach 80% (volume ratio), after 4 ℃ of mixings leave standstill 12 hours, use filter paper filtering, after filtrate is concentrated into alcohol volatilization totally, add distilled water diluting, promptly get the 1400ml traditional Chinese medicine composition extract liquid with the filtering with microporous membrane of 0.45 μ m, reconcentration is to 70ml.
3, the preparation of unguentum (1000g emulsifiable paste): take by weighing stearic acid 120g, glyceryl monostearate 30g, ethyl hydroxybenzoate 0.5g, white vaseline 50g, azone 40ml respectively by formula proportion, above-mentioned each component mixes common heating fusion back, back and forms the oil phase component mixed liquor, and it is standby to put into 82 ± 2 ℃ of water bath heat preservations; Taking by weighing potassium hydroxide 5g, triethanolamine 5ml, potassium sorbate 3g, Borax 10g respectively joins to stir in the 610ml distilled water and makes its dissolving, add 50ml glycerol, 50g liquid paraffin and traditional Chinese medicine composition extract liquid 70ml then, the mixing post-heating is to boiling, slowly join when temperature is 82 ± 2 ℃ in the oil phase component mixed liquor, condensation promptly gets unguentum behind the mixing.
(2), the test of pesticide effectiveness
1, is used for the treatment of the bovine subclinical mastitis test
A, test method: adopt international latent mammitis diagnostic method " California, USA mastitis test (CMT) " method to detect, list testing result in test for " ++ " or above trouble cattle.Choosing 10 sick cattle tests, 5 of test group, before treatment, clean the breast district of suffering from mastitis with warm water, after drying with dry towel, the unguentum 10-15g among the present invention is smeared in each ill breast district, 2 times/day, continuous use 7 days was a course of treatment, then with 5 blank group contrasts (blank group is not used any medicine).
B, criterion:
Cure: strong positive (+++) or positive (++) transfer feminine gender (-) or suspicious (±) to.
Effectively: strong positive (+++) or positive (++) transfer the weak positive (+) to.
Invalid: no change after the medication.
C, test effect:
Positive breast district number is 15 before 5 sick cattle medications of experimental group, is 2 after the medication, and cure rate is 86.67%, and effective percentage is 92.86%; And the positive breast district number of blank group is increased to 14 by 13, does not have mammary gland spontaneous recovery situation, and as seen, the unguentum among the present invention has good therapeutical effect to bovine subclinical mastitis.
2, be used for the treatment of the test of milch cow clinic mastitis
A, test method: by the diagnostic criteria of milch cow clinic mastitis, choose breast district's swelling, skin rubefaction, the palpation breast generates heat, has lump, pain sensitivity, milk yield to reduce, milk is unusual, flavescence white or serum sample, in ziega is arranged, comprehensive diagnos is that the milch cow of clinic mastitis is listed test in.Choosing 10 sick cattle tests, 5 of experimental grouies, before treatment, clean the breast district of suffering from mastitis with warm water, after drying with dry towel, the unguentum 12-17g among the present invention is smeared in each ill breast district, 2 times/day, continuous use 7 days was a course of treatment, then with 5 blank group contrasts (blank group is not used any medicine).
B, criterion:
Cure:, pain transference cure red, swollen, hot for breast, the milk perusal is normal, and the milk yield recovery is spiritual, appetite is normal, and somatic number drops to normal range in the milk.
Effectively:, pain sx red, swollen, hot for breast, the milk floccule disappears substantially or obviously reduces, and milk yield is gone up;
Invalid:, pain symptom red, swollen, hot for breast do not have obviously and alleviates, the clear rare or jaundice of milk, and flocculus is more obvious, and milk yield is not gone up, and general body state is not seen improvement.
C, test effect:
Positive breast district number is 16 before 5 sick cattle medications of experimental group, is 4 after the medication, and cure rate is 75.0%, and effective percentage is 87.50%; And the positive breast district number of blank group does not change, and as seen, unguentum of the present invention has good therapeutical effect to the milch cow clinic mastitis.
Embodiment 2:
(1), the preparation of compositions extracting solution and unguentum
1, prescription is formed: a kind of Chinese medicine composition of preventing and treating mammitis of cow is made by following parts by weight proportion raw material: Herba Taraxaci 4 parts of (120g), Flos Lonicerae 5 parts of (180g), Herba Violae 2 parts of (60g), Radix Angelicae Sinensis 4 parts of (120g), Fructus Trichosanthis 3 parts of (90g), Fructus Arctii 3 parts of (90g), Rhizoma Chuanxiong 2 parts of (60g), Pericarpium Citri Reticulatae Viride 3 parts of (90g), Radix Scutellariae 4 parts of (120g), 2 parts of Fructus Forsythiaes (60g).
2, the preparation of traditional Chinese medicine composition extract liquid: with embodiment 1, gained traditional Chinese medicine composition extract liquid 1000ml, reconcentration is to 50ml.
3, the preparation of unguentum (1000g emulsifiable paste): azone is 60ml in the oil phase mixed liquor, and other composition weight is with embodiment 1, and preparation method is with embodiment 1.
(2), the test of pesticide effectiveness
The test method of the test of pesticide effectiveness, criterion are with embodiment 1, and when the addition of azone was 60ml, the cure rate of latent mammitis was 81.43%, and effective percentage is 92.86%; The cure rate of clinic mastitis is 71.22%, and effective percentage is 83.33%; And the blank group does not all have mammary gland spontaneous recovery situation.
Embodiment 3:
(1), the preparation of traditional Chinese medicine composition extract liquid and unguentum
1, prescription is formed: a kind of Chinese medicine composition of preventing and treating mammitis of cow is made by following parts by weight proportion raw material: Herba Taraxaci 6 parts of (180g), Flos Lonicerae 4 parts of (120g), Herba Violae 6 parts of (180g), Radix Angelicae Sinensis 6 parts of (180g), Fructus Trichosanthis 7 parts of (210g), Fructus Arctii 6 parts of (180g), Rhizoma Chuanxiong 5 parts of (150g), Pericarpium Citri Reticulatae Viride 7 parts of (210g), Radix Scutellariae 6 parts of (180g), 6 parts of Fructus Forsythiaes (180g).
2, the preparation of traditional Chinese medicine composition extract liquid: with embodiment 1, gained traditional Chinese medicine composition extract liquid 1500ml, reconcentration is to 90ml.
3, the preparation of unguentum (1000g emulsifiable paste): azone is 20ml in the oil phase mixed liquor, and other composition weight is with embodiment 1, and preparation method is with embodiment 1.
(2), the test of pesticide effectiveness
The test method of the test of pesticide effectiveness, criterion are with embodiment 1, and when the addition of azone was 20ml, the cure rate of latent mammitis was 80.00%, and effective percentage is 86.67%; The cure rate of clinic mastitis is 70.59%, and effective percentage is 82.35%; And the blank group does not all have mammary gland spontaneous recovery situation.
Claims (5)
1, a kind of Chinese medicine composition of preventing and treating mammitis of cow is made by following parts by weight proportion raw material: Herba Taraxaci 4-6 part, Flos Lonicerae 3-6 part, Herba Violae 2-6 part, Radix Angelicae Sinensis 4-6 part, Fructus Trichosanthis 3-7 part, Fructus Arctii 3-6 part, Rhizoma Chuanxiong 2-5 part, Pericarpium Citri Reticulatae Viride 3-7 part, Radix Scutellariae 4-6 part, Fructus Forsythiae 2-6 part.
2,, it is characterized in that compositions made by following parts by weight proportion raw material: 5 parts of Herba Taraxacis, 5 parts of Flos Loniceraes, 5 parts of Herba Violaes, 5 parts of Radix Angelicae Sinensis, 5 parts of Fructus Trichosanthis, 5 parts of Fructus Arctiis, 4 parts of Rhizoma Chuanxiongs, 4 parts on Pericarpium Citri Reticulatae Viride, 4 parts of Radix Scutellariaes, 4 parts of Fructus Forsythiaes according to the Chinese medicine composition of the described control mammitis of cow of claim 1.
3, a kind of dosage form of being made by the Chinese medicine composition of claim 1 or 2 described control mammitis of cow is unguentum, injection, powder, decoct.
4, the Chinese medicine composition of control mammitis of cow according to claim 3, the emulsifiable paste matrix that it is characterized in that unguentum is by stearic acid, glyceryl monostearate, ethyl hydroxybenzoate, white vaseline, azone; The water group component is potassium hydroxide, triethanolamine, potassium sorbate, Borax, glycerol, liquid paraffin, distilled water formation; Stearic acid 120g, glyceryl monostearate 30g, ethyl hydroxybenzoate 0.5g, white vaseline 50g, azone 20-60ml in the emulsifiable paste matrix of every 1000g unguentum; The water group component is potassium hydroxide 5g, triethanolamine 5ml, potassium sorbate 3g, Borax 10g, glycerol 50ml, liquid paraffin 50g, distilled water 610ml.
5, the Chinese medicine composition unguentum of control mammitis of cow according to claim 4 is characterized in that the azone in the emulsifiable paste matrix is 40ml.
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| CNB200610150996XA CN100464768C (en) | 2006-11-05 | 2006-11-05 | Chinese medicinal composition for preventing and treating cow mastitis |
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| CNB200610150996XA CN100464768C (en) | 2006-11-05 | 2006-11-05 | Chinese medicinal composition for preventing and treating cow mastitis |
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| CN1965976A true CN1965976A (en) | 2007-05-23 |
| CN100464768C CN100464768C (en) | 2009-03-04 |
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| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN101810712B (en) * | 2009-11-16 | 2011-08-17 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for preventing and treating mastitis of female animals and preparation method thereof |
| CN101406609B (en) * | 2008-11-18 | 2011-08-24 | 布焕景 | External-use medicament for treating breast inflammation of milk cattle |
| CN102293870A (en) * | 2011-08-27 | 2011-12-28 | 广东省农业科学院兽医研究所 | Traditional Chinese medicine composition used for preventing and treating cow recessive mastitis and preparation method thereof |
| CN102846795A (en) * | 2012-10-22 | 2013-01-02 | 新疆维吾尔自治区畜牧科学院兽医研究所 | Chinese medicine composition for preventing and treating mastitis of dairy cattle and preparation method thereof |
| CN104324111A (en) * | 2014-10-10 | 2015-02-04 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicine feed additive for preventing dairy cow postpartum mastitis |
| CN104491203A (en) * | 2014-12-11 | 2015-04-08 | 郑州后羿制药有限公司 | Chinese herbal medicine fermentative extract liquid for preventing and treating cow mastitis and preparation method of Chinese herbal medicine fermentative extract liquid |
| CN104667166A (en) * | 2013-12-03 | 2015-06-03 | 天津市中敖饲料有限公司 | Traditional Chinese medicine composition for treating clinical mastitis of dairy cow and preparation method of traditional Chinese medicine composition |
| CN104800421A (en) * | 2015-04-23 | 2015-07-29 | 河南省首家中兽医药服务有限公司 | Traditional Chinese medicine powder for preventing and treating cow subclinical mastitis |
| CN105918631A (en) * | 2016-04-28 | 2016-09-07 | 青岛海之星生物科技有限公司 | Feed additive for preventing cow subclinical mastitis and preparation method thereof |
| CN106511999A (en) * | 2016-12-06 | 2017-03-22 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition used for preventing and treating mastitis and carbuncle swelling of dairy cow as well as preparation method and application of drug composition |
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN115531518A (en) * | 2022-09-22 | 2022-12-30 | 湖南科技学院 | Traditional Chinese medicine ointment for preventing and treating cow mastitis and preparation method thereof |
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| RU2669929C1 (en) * | 2017-07-21 | 2018-10-17 | Федеральное государственное бюджетное научное учреждение "Федеральный Алтайский научный центр агробиотехнологий" (ФГБНУ ФАНЦА) | Preparation for treatment of cows suffering from mastitis and method of its production |
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| CN1084630C (en) * | 1999-03-20 | 2002-05-15 | 胡清华 | Mastopathy treating ointment |
| CN100420480C (en) * | 2004-06-01 | 2008-09-24 | 闫丽娟 | Pillows for mastosis, e.g., hyperplasia, tumours and other diseases |
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- 2006-11-05 CN CNB200610150996XA patent/CN100464768C/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406609B (en) * | 2008-11-18 | 2011-08-24 | 布焕景 | External-use medicament for treating breast inflammation of milk cattle |
| CN101810712B (en) * | 2009-11-16 | 2011-08-17 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicinal composition for preventing and treating mastitis of female animals and preparation method thereof |
| CN102058667B (en) * | 2011-01-07 | 2012-04-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102058667A (en) * | 2011-01-07 | 2011-05-18 | 河南亚卫动物药业有限公司 | Chinese medical intramammary infusion for treating mastitis of dairy cows and preparation method thereof |
| CN102293870A (en) * | 2011-08-27 | 2011-12-28 | 广东省农业科学院兽医研究所 | Traditional Chinese medicine composition used for preventing and treating cow recessive mastitis and preparation method thereof |
| CN102293870B (en) * | 2011-08-27 | 2013-03-13 | 广东省农业科学院兽医研究所 | Traditional Chinese medicine composition used for preventing and treating cow recessive mastitis and preparation method thereof |
| CN102846795A (en) * | 2012-10-22 | 2013-01-02 | 新疆维吾尔自治区畜牧科学院兽医研究所 | Chinese medicine composition for preventing and treating mastitis of dairy cattle and preparation method thereof |
| CN104667166A (en) * | 2013-12-03 | 2015-06-03 | 天津市中敖饲料有限公司 | Traditional Chinese medicine composition for treating clinical mastitis of dairy cow and preparation method of traditional Chinese medicine composition |
| CN104324111B (en) * | 2014-10-10 | 2016-06-29 | 青岛嘉瑞生物技术有限公司 | A kind of Chinese herbal feed additive preventing milch cow puerperal mastitis |
| CN104324111A (en) * | 2014-10-10 | 2015-02-04 | 青岛嘉瑞生物技术有限公司 | Chinese herbal medicine feed additive for preventing dairy cow postpartum mastitis |
| CN104491203A (en) * | 2014-12-11 | 2015-04-08 | 郑州后羿制药有限公司 | Chinese herbal medicine fermentative extract liquid for preventing and treating cow mastitis and preparation method of Chinese herbal medicine fermentative extract liquid |
| CN104800421A (en) * | 2015-04-23 | 2015-07-29 | 河南省首家中兽医药服务有限公司 | Traditional Chinese medicine powder for preventing and treating cow subclinical mastitis |
| CN105918631A (en) * | 2016-04-28 | 2016-09-07 | 青岛海之星生物科技有限公司 | Feed additive for preventing cow subclinical mastitis and preparation method thereof |
| CN106511999A (en) * | 2016-12-06 | 2017-03-22 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition used for preventing and treating mastitis and carbuncle swelling of dairy cow as well as preparation method and application of drug composition |
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN115531518A (en) * | 2022-09-22 | 2022-12-30 | 湖南科技学院 | Traditional Chinese medicine ointment for preventing and treating cow mastitis and preparation method thereof |
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