CN102114175A - Compound preparation for treating acute mastitis of milk cow - Google Patents

Abstract

The invention relates to a compound preparation for treating acute mastitis of a milk cow and the preparation method thereof. The composition mainly comprises lincomycin hydrochloride, houttuynia, honeysuckle flower, weeping forsythia fruit, dandelion, Chinese angelica root, luffa, ricepaper plant pith, cotton rose hibiscus leaves, chekiang fritillary bulb, cosolvent, preservative and proper amount of water for injection. The composition provided by the invention has the advantages of quick action and small irritation, is not easy to generate drug tolerance, and is used for treating both principal and secondary aspect of disease. The prepared compound preparation is injection which is convenient for application and easy for operation and can be easily accepted by farmers.

Description

A kind of compound preparation that is used for the treatment of acute mammitis of cow

Technical field

The invention belongs to the herbal medicine technical field, particularly relate to a kind of compound preparation that is used for the treatment of acute mammitis of cow and preparation method thereof.

Background technology

Mammitis of cow is one of four big diseases of milch cow, and this cause of disease it cause milch cow output to descend, and sick breast is distinguished the discarded of milk, severe patient, gangrene is suppurated in the breast district, atrophys etc. cause the permanent ability of losing and lose it and be worth, therefore and the milch cow of eliminating account for total eliminate 40%～60%.Foreign study report mammitis of cow sickness rate is 20%～70%, and the sickness rate of China's report is 40%～80%.And mammitis of cow is divided into three types: acute mastitis, latent mammitis, chronic mammitis, the present invention mainly is the drug development at acute mastitis.

The cardinal symptom of acute mastitis is a sudden onset, and it is rubescent to show as skin of breast, edema, and swelling can reach 2-3 times of normal volume sometimes, observes from the milch cow rear quarters, and morbidity breast district is asymmetric with normal breast.The district's hardening of morbidity breast, the pain of touching, sensitivity.Majority is one or two breast district morbidity together, and three, four breasts are distinguished the less of morbidity simultaneously.Milk is undesired, and the district's beginning of morbidity breast can only be extruded a small amount of milk because of swelling, and milk does not also degenerate, a small amount of clear water can only be extruded subsequently,, a small amount of corrupt milk that degenerates can only be extruded along with the development of the state of an illness, the breast district milk yield of not having morbidity also obviously reduces, but milk is not bad.Most cases, suffering from cattle has fervescence, and spirit is depressed, inappetence, the sick cattle that has is because of the limping that occurs together of breast district pain, General Symptoms such as tremble.This disease such as timely symptomatic treatment, multipotency is cured, but very easily changes the chronic and latent mammitis of milch cow slowly into as untimely treatment or treatment.And cause after the chronic mammitis, more refractory is treated recovery from illness, and the cost medical expense is more.

Find that according to the market actual survey the main medicine for the treatment of mammitis of cow at present clinically is antibiotics injection, Chinese powder medicine and injections of Chinese medicine, and find that according to investigation the administering mode that is applicable to cattle is the injection injection.Wherein the medicine of antibiotics be easy to generate drug resistance, easily repeatedly, abandon problems such as the milk phase is long, the Chinese medicine preparation treatment is slower the course of treatment, if untimely treatment is easy to transfer to chronic mammitis and latent mammitis as acute mastitis, therefore use antibiotics or Chinese medicine class medicine all to have some drawbacks separately.Therefore the present invention has adopted the Chinese and Western combination, utilizes the produce effects of antibiotics fast, treat fast advantage, is difficult in conjunction with Chinese medicine class medicine again that generation drug resistance, zest are little, the advantage for the treatment of both the principal and secondary aspects of a disease, the bonded injection in the Chinese and Western that makes.

Summary of the invention

Purpose one of the present invention provides a kind of compound preparation that is used for the treatment of acute mammitis of cow.

Purpose two of the present invention provides the preparation method of the compound preparation of this treatment acute mammitis of cow.

A kind of compound preparation that is used for the treatment of acute mammitis of cow of the present invention, mainly by lincomycin hydrochloride, the middle drug solns that Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii are made, cosolvent, antiseptic etc. are formed with proper amount of water for injection.

Above-mentioned compound preparation, each component content scope is: lincomycin hydrochloride 5-10% (W/V), the middle drug solns that Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii are made (every 1ml contains crude drug in whole 1.0g) (20%-50%), benzyl alcohol 5-15% (V/V), EDTA-2Na 0.1-1% (W/V), ethanol 5-15% (V/V), propylene glycol 5-15% (V/V).

Each component content scope of above-mentioned compound preparation is preferably: lincomycin hydrochloride 7.5% (W/V), the middle drug solns that Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii are made (every 1ml contains crude drug in whole 1.0g) (40%), benzyl alcohol 10% (V/V), EDTA-2Na 0.2% (W/V), ethanol 10% (V/V), propylene glycol 10% (V/V).

Be to be the middle drug solns (every 1ml contains crude drug in whole 1.0g) that Herba Houttuyniae 20-30 part, Flos Lonicerae 1-3 part, Fructus Forsythiae 1-3 part, Herba Taraxaci 20-30 part, Radix Angelicae Sinensis 10-15 part, Retinervus Luffae Fructus 0.5-2 part, Medulla Tetrapanacis 1-5 part, Folium Hibisci Mutabilis 1-3 part, Bulbus Fritillariae Thunbergii 1-3 part are made in the drug solns in above-mentioned by parts by weight.

Drug solns is realized by following technical step in described:

(1) weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.

(2) get the Chinese medicine medical material of getting ready and added the injection water wetness impregnation one hour, decocted 40～60 minutes, filter, residue adds injection water again and decocts secondary, merging filtrate, and evaporation and concentration to relative density is the clear paste of 1.20 (80 ℃), add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, filter, reclaim ethanol, add injection and be diluted with water to the solution that contains primary crude drug 1.0g among every 1ml.

The compound preparation of described treatment acute mammitis of cow is realized by following technical step:

(1) according to above-mentioned prescription weighing, neck material, standby.

(2) it is an amount of to get water for injection, under stirring, adds lincomycin hydrochloride, EDTA-2Na successively, stirs it is dissolved fully, adds ethanol, propylene glycol then, stirs fully dissolving, obtains A liquid.

(3) with A liquid and above-mentioned middle drug solns mixing and stirring, slowly add benzyl alcohol, regulate pH value, be diluted to recipe quantity, filter with water for injection between the 5.5-7.0, packing, embedding, sterilization promptly gets this medicinal liquid

Beneficial effect of the present invention:

1, the present invention has used the bonded method in Chinese and Western, and produce effects is fast, and treatment is fast, is difficult for producing drug resistance, little, the treating both the principal and secondary aspects of a disease of zest.

2, compound preparation of the present invention is the injection injection, and is easy to use, is beneficial to operation, easily accepted by numerous raisers.

The specific embodiment

The present invention will be further described below in conjunction with embodiment.

Embodiment one:

Prescription:

The Chinese medicine solution formula:

Herba Houttuyniae 1667g

Flos Lonicerae 67g

Fructus Forsythiae 133g

Herba Taraxaci 1500g

Radix Angelicae Sinensis 670g

Retinervus Luffae Fructus 67g

Medulla Tetrapanacis 133g

Folium Hibisci Mutabilis 67g

Bulbus Fritillariae Thunbergii 67g

Make drug solns among the 5000ml

Lincomycin hydrochloride 750g

EDTA-2Na 20g

Ethanol 1000ml

Propylene glycol 1000ml

Benzyl alcohol 1000ml

Middle drug solns 4000ml

The water for injection interpolation is concentrated into 10L.

Preparation method:

1, weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.

2, get the Chinese medicine medical material of getting ready and added the injection water wetness impregnation one hour, decocted 40～60 minutes, filter, residue adds injection water again and decocts secondary, merging filtrate, and evaporation and concentration to relative density is the clear paste of 1.20 (80 ℃), add 2～3 times of amount 95% alcohol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, filter, reclaim ethanol, add injection and be diluted with water to every 5000ml.

3, get 2000ml water for injection, under stirring, add lincomycin hydrochloride, EDTA-2Na successively, stirring is dissolved it fully, adds ethanol, propylene glycol then, stirs fully dissolving, obtains A liquid.

4, above-mentioned A liquid and the merging of middle drug solns are mixed, slowly add benzyl alcohol, regulate pH value, be diluted to 10 liters, filter with water for injection between the 5.5-7.0, packing, embedding, 100 ℃ of sterilizations in 30 minutes promptly get this medicinal liquid.

Embodiment two: by the effect of clinical trial proof compound preparation of the present invention.

1. material

1.1 trial drug:

The injection of A, the embodiment of the invention one preparation;

The powder of the treatment mammitis of cow of B, certain company

C, lincomycin hydrochloride injection (30%)

1.2 test milch cow:

Choose milk cattle cultivating field, Ninghe County, Tianjin and suffer from the milch cow of acute mastitis

2. method

Choose 15 of the trouble cattle of the acute mastitis of milk cattle cultivating field, Ninghe County, Tianjin, be divided into 3 groups at random, per 5 is one group, and wherein the A group is as treatment, and B group and C group be group in contrast, (every kg body weight 0.1ml) used in the intramuscular injection of A group, logotype 3 days, contrast B group spice (1g spice 1kg), logotype 3 days, contrast C group injection (every kg body weight 0.05ml), logotype 3 days.During the medication without any other medicine.Observed 10 days record treatment situation continuously.

3. curative effect judging standard

Cure: transference cure after the medication, body temperature is normal, and body recovery is normal in 7 days, and it is normal that milk yield recovers.

Effectively: sx after the medication, body recover normally substantially, milk yield recovers gradually.

Invalid: symptom does not subtract after the medication, and body development is affected.

4. result and analysis: see the following form:

After the medication 3 days, the treatment of A group is organized disease cattle spirit and is taken a turn for the better, and feed intake increases, and hyperpyrexia is decorporated, and morbidity breast district takes a turn for the better, no lump, and that touches is reactionless; Contrast B organizes disease cattle spirit and takes a turn for the better, the fever sx, and the reaction that morbidity breast district touches has the pain performance, and morbidity cow feeding amount slightly increases; Contrast C group, change of illness state slightly take a favorable turn, and observes disease Lac Bovis seu Bubali district, has 4 cattle to turn for the better by and large, and other one also will be continued to observe.According to above data show, use medicine of the present invention that the treatment acute mammitis of cow is had good curative effect.

Claims (7)

1. compound preparation that is used for the treatment of acute mammitis of cow is characterized in that described compositions mainly is made up of with proper amount of water for injection lincomycin hydrochloride, Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii, cosolvent, antiseptic etc.

2. a kind of compound preparation that is used for the treatment of acute mammitis of cow according to claim 1 is characterized in that solution, cosolvent, antiseptic and proper amount of water for injection that described compositions is made by lincomycin hydrochloride, above-mentioned Chinese medicinal ingredients form.

3. a kind of compound preparation that is used for the treatment of acute mammitis of cow according to claim 1 and 2, it is characterized in that each component content scope is: lincomycin hydrochloride 5-10% (W/V), the middle drug solns that Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii are made (every 1ml contains crude drug in whole 1.0g) (20%-50%), benzyl alcohol 5-15% (V/V), EDTA-2Na 0.1-1% (W/V), ethanol 5-15% (V/V), propylene glycol 5-15% (V/V), water for injection are an amount of.

4. according to the described a kind of compound preparation that is used for the treatment of acute mammitis of cow of claim 1 to 3, it is characterized in that each component content scope is preferably: lincomycin hydrochloride 7.5% (W/V), the middle drug solns that Herba Houttuyniae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Angelicae Sinensis, Retinervus Luffae Fructus, Medulla Tetrapanacis, Folium Hibisci Mutabilis, Bulbus Fritillariae Thunbergii are made (every 1ml contains crude drug in whole 1.0g) (40%), benzyl alcohol 10% (V/V), EDTA-2Na 0.2% (W/V), ethanol 10% (V/V), propylene glycol 10% (V/V).

5. according to the described a kind of compound preparation that is used for the treatment of acute mammitis of cow of claim 1 to 4, it is characterized in that in the described middle drug solns be to be by parts by weight: the middle drug solns (every 1ml contains crude drug in whole 1.0g) that Herba Houttuyniae 20-30 part, Flos Lonicerae 1-3 part, Fructus Forsythiae 1-3 part, Herba Taraxaci 20-30 part, Radix Angelicae Sinensis 10-15 part, Retinervus Luffae Fructus 0.5-2 part, Medulla Tetrapanacis 1-5 part, Folium Hibisci Mutabilis 1-3 part, Bulbus Fritillariae Thunbergii 1-3 part are made.

6. a kind of compound preparation that is used for the treatment of acute mammitis of cow according to claim 5 is characterized in that the solution that Chinese medicinal ingredients is made realizes by following technical step:

(1) weighing, clean: weigh up medical material by recipe quantity, the impurity of sneaking in the medical material is removed, the medical material that selection is good is put in the clean container.

(2) get the Chinese medicine medical material of getting ready and added the injection water wetness impregnation one hour, decocted 40～60 minutes, filter, residue adds injection water again and decocts secondary, merging filtrate, and evaporation and concentration to relative density is the clear paste of 1.20 (80 ℃), add 2～3 times of amount 95% ethanol, fully stir, place more than 12 hours, filter, disgorging reclaims ethanol, add ethanol 2～3 times till do not have a precipitation by last method, filter, reclaim ethanol, add injection and be diluted with water to the solution that contains primary crude drug 1.0g among every 1ml.

7. according to the described a kind of compound preparation that is used for the treatment of acute mammitis of cow of claim 1 to 6, it is characterized in that described compound preparation realizes by following technical step:

(1) according to above-mentioned prescription weighing, neck material, standby.

(2) it is an amount of to get water for injection, under stirring, adds lincomycin hydrochloride, EDTA-2Na successively, stirs it is dissolved fully, adds ethanol, propylene glycol then, stirs fully dissolving, obtains A liquid.

(3) with the middle drug solns mixing and stirring of making in the A liquid claim 5, slowly add benzyl alcohol, regulate pH value, be diluted to recipe quantity, filter with water for injection between the 5.5-7.0, packing, embedding, sterilization promptly gets this medicinal liquid.