CN104054973A - Feed used for improving immune function of carp - Google Patents
Feed used for improving immune function of carp Download PDFInfo
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- CN104054973A CN104054973A CN201410322057.3A CN201410322057A CN104054973A CN 104054973 A CN104054973 A CN 104054973A CN 201410322057 A CN201410322057 A CN 201410322057A CN 104054973 A CN104054973 A CN 104054973A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
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- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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Abstract
The invention provides a traditional Chinese medicinal feed additive used for improving the immune function of carp. The traditional Chinese medicinal feed additive comprises the following raw medicaments: hawthorn, companumoea root, mosla soochouensis matsuda, white peony root, mistletoe, Chinese yam, rhubarb grown on mountain, gordon euryale, vine of multiflower knotweed, radix pseudostellariae, liriope spicata, cistanche, angelica sinensis, eclipta, adenophora tetraphylla, gallnut, cocklebur fruit, saururus chinensis, selfheal, rice bean seed and commeline communis. By feeding the feed, the production performance of the carp can be improved, the immunity and the anti-disease regulating force of fish bodies are enhanced, any toxic or side effect cannot be brought, and the feed does not have any harm to human bodies.
Description
Technical field
The present invention relates to field of feed, relate in particular to a kind of for improving the feed of carp immunologic function.
Background technology
Carp another name carp cripple, carp, formal name used at school
cyprinus carpio, be under the jurisdiction of Cypriniformes Cyprinidae, be that Asia originates in temperate zone fresh water fish, like living in the rivers and creeks of warm lake on Plain or sluggish flow.Carp is the same with most fresh-water fishes to be belonged to without stomach fingerling, and enteron aisle is carefully short, and rate of metabolism is fast, therefore eating habit is for eating less diligent food.Carp is the omnivorousness demersal fishes of high-output stress-resistance, is one of traditional freshwater aquiculture kind of China, is also to cultivate in the world one of fish the most widely.Because its delicious meat is delicate, thorn is few, moderate cost, nutritious, very popular, have the good reputation of " first of chinese carp ".
In recent years, along with the high density intensivization development of aquaculture, the breaking out to culture fishery and brought massive losses on a large scale of disease.And the current antibiotic generally using has the drawbacks such as animal immunizing power, polluted water and the medicament residue of reduction.Antibiotic a large amount of use can cause that the water environment degradation, soil pollution in aquaculture old liberated area is serious, pathogenic microorganism produces drug resistance, aquatic products quality declines, the residual a series of serious problems such as exceed standard of medicine.Therefore, seek can substitute antibiotics green feed additive be current culture fishery urgent problem.
Chinese herbal medicine natural plants additive is a kind of green feed additive with bright prospects, it have natural, efficient, toxic and side effect is little, the resistance to the action of a drug not significantly, aboundresources and the advantage such as performance is various, when improving aquatic livestock production performance and efficiency of feed utilization, there is again immunoregulation effect, and can fully guarantee the health of human body, having medical and trophism double action concurrently, is that chemical synthesis feed addictive is incomparable.Improve the production performance of cultured fishes, strengthen immunity and the disease-resistant adjusting power of fish body simultaneously, taking to rely mainly on prevention is to make the not sick or few sick key factor of fish.
Natural plants contains abundant organic principle, wherein the multiple compounds such as plant polyose, flavonoids can participate in the various physiological metabolisms of body, has to regulate immunity of organism, suppress tumour, delay senility, hypoglycemic, radioresistance, anti-bacteria and anti-virus, adjusting blood fat, improve the several functions such as the speed of growth.Natural plant extracts (flavonoids, polysaccharide) is just shown up prominently in the application in aquatic products field, and it has become focus as the research and development of Novel fish feed addictive in China.
The present invention takes full advantage of medical and the trophism double action that Chinese herbal feed additive has, a kind of feed that contains Chinese herbal feed additive has been proposed, by giving this feed of carp feeding, can improve the production performance of fish, strengthen immunity and the disease-resistant adjusting power of fish body, and it can not bring any toxic and side effect, to human body without any injury.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed for improving the Chinese herbal feed additive of carp production performance and containing this feed addictive, by this feed of feeding, can improve the production performance of carp, strengthen immunity and the disease-resistant adjusting power of fish body, and it can not bring any toxic and side effect, to human body without any injury.
For solving the problems of the technologies described above, the invention provides a kind ofly for improving the Chinese herbal feed additive of carp immunologic function, its bulk drug comprises hawthorn, Companumoea root, suchow mosla herb, the root of herbaceous peony, parasitic loranthus, Chinese yam, franzenbach rhubarb root and rhizome, Gorgon fruit, the vine of multiflower knotweed, radix pseudostellariae, Radix Liriopes, saline cistanche, Radix Angelicae Sinensis, eclipta, adenophora tetraphylla, Chinese gall, the achene of Siberian cocklebur, saururus chinensis, selfheal, rde bean and Commeline communis.
Wherein, in described Chinese herbal feed additive, the weight portion of each bulk drug is respectively hawthorn 25 weight portion～35 weight portions, Companumoea root 35 weight portion～45 weight portions, suchow mosla herb 20 weight portion～30 weight portions, the root of herbaceous peony 20 weight portion～30 weight portions, parasitic loranthus 35 weight portion～45 weight portions, Chinese yam 55 weight portion～65 weight portions, franzenbach rhubarb root and rhizome 25 weight portion～35 weight portions, Gorgon fruit 30 weight portion～40 weight portions, the vine of multiflower knotweed 25 weight portion～35 weight portions, radix pseudostellariae 70 weight portion～80 weight portions, Radix Liriopes 45 weight portion～55 weight portions, saline cistanche 35 weight portion～45 weight portions, Radix Angelicae Sinensis 35 weight portion～45 weight portions, eclipta 40 weight portion～50 weight portions, adenophora tetraphylla 35 weight portion～45 weight portions, Chinese gall 20 weight portion～30 weight portions, the achene of Siberian cocklebur 35 weight portion～45 weight portions, saururus chinensis 20 weight portion～30 weight portions, selfheal 25 weight portion～35 weight portions, rde bean 35 weight portion～45 weight portions and Commeline communis 20 weight portion～30 weight portions.
Wherein, in described Chinese herbal feed additive, the weight portion of each bulk drug is respectively hawthorn 28 weight portion～32 weight portions, Companumoea root 38 weight portion～42 weight portions, suchow mosla herb 23 weight portion～27 weight portions, the root of herbaceous peony 23 weight portion～27 weight portions, parasitic loranthus 38 weight portion～42 weight portions, Chinese yam 58 weight portion～62 weight portions, franzenbach rhubarb root and rhizome 28 weight portion～32 weight portions, Gorgon fruit 33 weight portion～37 weight portions, the vine of multiflower knotweed 28 weight portion～32 weight portions, radix pseudostellariae 73 weight portion～77 weight portions, Radix Liriopes 48 weight portion～52 weight portions, saline cistanche 38 weight portion～42 weight portions, Radix Angelicae Sinensis 38 weight portion～42 weight portions, eclipta 43 weight portion～47 weight portions, adenophora tetraphylla 38 weight portion～42 weight portions, Chinese gall 23 weight portion～27 weight portions, the achene of Siberian cocklebur 38 weight portion～42 weight portions, saururus chinensis 23 weight portion～27 weight portions, selfheal 28 weight portion～32 weight portions, rde bean 38 weight portion～42 weight portions and Commeline communis 23 weight portion～27 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese herbal feed additive, be specially each bulk drug of described Chinese herbal feed additive is uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, add the water with respect to 4 ~ 6 times of powder qualities, soak 4 ~ 8 hours, then decoct 2 ~ 4 hours, concoction is poured out, again add the water with respect to 2 ~ 4 times of powder qualities, decoct 1 hour ~ 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive.
It is a kind of for improving the feed of carp production performance that the present invention also provides, and its raw material comprises above-mentioned for improving Chinese herbal feed additive, Choline Chloride, inositol, vitamin C, fish meal, dregs of beans, wheat bran, calcium dihydrogen phosphate, dusty yeast, sodium alginate, methionine, threonine, salt, Copper lysinate and the manganese sulfate of carp production performance.
Wherein, the weight portion of described each raw material is respectively described Chinese herbal feed additive 10 weight portion～20 weight portions, Choline Chloride 0.2 weight portion～0.5 weight portion, inositol 0.2 weight portion～0.5 weight portion, vitamin C 0.2 weight portion～0.5 weight portion, fish meal 35 weight portion～45 weight portions, dregs of beans 20 weight portion～30 weight portions, wheat bran 15 weight portion～25 weight portions, calcium dihydrogen phosphate 1.5 weight portion～2.5 weight portions, dusty yeast 3 weight portion～5 weight portions, sodium alginate 0.5 weight portion～1 weight portion, methionine 0.3 weight portion～0.6 weight portion, threonine 0.3 weight portion～0.6 weight portion, salt 0.5 weight portion～1 weight portion, Copper lysinate 0.1 weight portion～0.3 weight portion, manganese sulfate 0.1 weight portion～0.3 weight portion.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese herbal feed additive according to method above;
Second step, it is even that the Chinese herbal feed additive that the first step is obtained and other each components in described feed are sent into stirrer for mixing in proportion;
The 3rd step, the material mixing carries out modified, and temperature is controlled at 90 ~ 95 ℃, and modulating time 55 ~ 65 seconds is granulated subsequently, and cooling, pellet composition is cooling, and temperature is controlled at 20 ~ 25 ℃, packing.
Beneficial effect of the present invention:
The invention provides the feed for improving the Chinese herbal feed additive of carp production performance and containing this feed addictive, by this feed of feeding, can improve the production performance of carp, strengthen immunity and the disease-resistant adjusting power of fish body, and it can not bring any toxic and side effect, to human body without any injury.
The specific embodiment
The invention provides a kind ofly for improving the Chinese herbal feed additive of carp immunologic function, its bulk drug comprises hawthorn, Companumoea root, suchow mosla herb, the root of herbaceous peony, parasitic loranthus, Chinese yam, franzenbach rhubarb root and rhizome, Gorgon fruit, the vine of multiflower knotweed, radix pseudostellariae, Radix Liriopes, saline cistanche, Radix Angelicae Sinensis, eclipta, adenophora tetraphylla, Chinese gall, the achene of Siberian cocklebur, saururus chinensis, selfheal, rde bean and Commeline communis.
Further, described Chinese herbal feed additive only consists of above-mentioned raw materials medicine.
The pharmacology of described each bulk drug is as follows:
Hawthorn: taste acid, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, has food digesting stomach fortifying, the effect of the loose stasis of blood of promoting the circulation of qi, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, and dysentery, hawthorn is the staple for the treatment of indigestion, and hawthorn can increase the secretion of peptic digest enzyme, promotes the cards such as digestion.
Companumoea root: latin name
radix campanumoea javanicae, be the root of Campanulaceae leopard platymiscium Campanumoea javanica and leopard, taste is sweet, and property is flat, returns lung, the spleen channel, have strengthening the spleen and replenishing qi, tonify the lung to relieve cough, the effect of lactogenesis, cures mainly the empty internal injury of labor, and the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea, leukorrhea, milk is rare, the cards such as insufficiency of the spleen cough.
Suchow mosla herb: warm in nature, taste is pungent, has dispelling summer-heat to relieve superficies syndrome, the effect of regulating qi-flowing for relieving pain, cures mainly flu, heatstroke, eruptive disease, peratodynia, the cards such as abscess of throat.
The root of herbaceous peony: latin name
paeoniae Radix Alba, bitter, acid, cool in nature, enter liver, the spleen channel, there is nourishing blood and liver, slow middle pain relieving, astringe yin is received the effect of sweat, cures mainly chest abdomen pain over the hypochondriac region, rushes down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, is with inferior card.
Parasitic loranthus: bitter, sweet, property is flat, enters liver, kidney channel, have the effect of filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic, antiabortive unit, for the soreness of waist pain due to kidney deficiency and liver, muscles and bones impotence is soft, the foot and knee being feeble, kidney deficiency and liver, essence and blood is empty to be lost, the fetal irritability of liability to be abortion, the cards such as waist abdomen pain.
Chinese yam: latin name
dioscoreae rhizoma, taste is sweet, property is flat, enters lung, spleen, stomach warp, has tonifying spleen nourishing the stomach, beneficial lung reinforces the kidney, the effect of nourishing Yin and promoting production of body fluid, cure mainly weakness of the spleen and the stomach, the card such as it is poor that the food of the dysfunction of the spleen in transport is received less, the vexed diarrhoea of gastral cavity.
Franzenbach rhubarb root and rhizome: latin name
radix et Rhizome Rhei Franzenbachii, be the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter; Cold in nature, return stomach; Large intestine channel, has the removing toxic substances of purging heat; The effect of the cool blood stasis of blood, cures mainly jaundice with damp-heat pathogen; Dysentery; Through closing stomachache; Hematemesis and epistaxis; Fall and beat stasis of blood pain; The carbuncle serious case of furuncle that swells; The erosion of mucous membrane in the oral cavity; The cards such as burn and scald.
Gorgon fruit: taste is sweet, puckery, property is flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, clearing damp is the function of band only, cures mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, is with inferior card.
The vine of multiflower knotweed: taste is sweet, property is flat, and the thoughts of returning home, Liver Channel, have nourishing blood and tranquilization, and the effect of dispelling wind and removing obstruction in the meridians, cures mainly insomnia and dreamful sleep, deficiency of blood bodily pain, arthralgia due to wind-dampness; The cards such as pruitus.
Radix pseudostellariae: sweet, the micro-hardship of taste, property is flat, enters spleen, lung channel, has air making-up and spleen enlivening, the effect that moistening lung is promoted the production of body fluid, for the few burnout of food of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, the beneficial temper of energy, nourishing stomach-YIN, many for the deficiency syndrome of the lung cough caused by dryness of deficiency of vital energy Tianjin wound and palpitaition egersis, abnormal heat sweat, can nourishing generate fluid.
Radix Liriopes: latin name
liriopes radix, sweet, the micro-hardship of taste, cold nature, the thoughts of returning home, lung, stomach warp, have nourishing Yin and promoting production of body fluid, the effect that moistening lung clears away heart-fire, for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as the dry constipation of intestines.
Saline cistanche: be the fleshy stem of Orobanchaceae Cistanche deserticola Vegetable meat desert cistanche and Cistanche tubulosa, latin name
herba cistanches, taste is sweet, salty, warm in nature, enters kidney, large intestine channel, there are kidney-replenishing, benefiting essence-blood, the effect relaxing bowel, for decline of kidney-YANG, the impotence and premature ejaculation of asthenia of essence and blood, infertile, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, the intestines of the suffering from a deficiency of the kidney deficiency of blood in dry and postpartum, the cards such as constipation that body fluid deficiency after being ill.
Radix Angelicae Sinensis: latin name
angelicae sinensis radix, taste is sweet, pungent, warm in nature, enters liver, the heart, the spleen channel, and enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect relaxing bowel, is mainly used in having a dizzy spell of deficiency of heart-blood, lassitude hypodynamia, palpitation, and other syndrome of blood deficiency; The sea of blood is hollow, the irregular menstruation of the cold and deficiency of chong and ren channels or extravasated blood retardance, and dysmenorrhoea, produces or stomachache, and other blood stasis are had a pain and the few dry cards such as constipation of intestines of deficiency of Yin blood.
Eclipta: have another name called Eclipta prostrata, China ink grass, floods and droughts lotus, taste is sweet, sour, cold in nature, returns liver, kidney channel, plays not liver and kidney benefiting, the effect of cooling blood and hemostasis, for having a dizzy spell due to the deficiency of liver-yin and kidney-yin, blurring of vision, soreness and weakness of waist and knees; Be suitable for the deficiency of Yin and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the symptoms such as the hemoptysis of heat impairing pulmonary collateral, eclipta has inhibitory action to staphylococcus aureus, typhoid bacillus, Song's Shigella flexneri, Pseudomonas aeruginosa, can obviously strengthen nospecific immunity and cellular immune function.
Adenophora tetraphylla: sweet, the micro-hardship of taste, cold nature, enter lung, stomach warp, moisten the lung and relieve the cough, the effect of nourishing the stomach to improve the production of body fluid, is mainly used in the few phlegm of the lung-dryness syndrome due to yin deficiency, dry cough, the labor phlegm blood of coughing, the cards such as the pharynx of deficiency of stomach-Yin, mouthfeel is dry, constipation, the red few tongue of tongue, can improve cellular immunity and non-specific immunity, suppress humoral immunity, there is the function that regulates immunologic balance.
Chinese gall: latin name
galla Chinensis,taste acid, puckery, cold in nature, return lung, large intestine, kidney channel, have that convergence is astringent or styptic treatment for spontaneous sweating, an effect of nourishing generate fluid, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Protracted dysentery is rushed down for a long time; Prolapse of the anus; Seminal emission; Gonorrhoea; Various hemorrhage; The cards such as the swollen sore furuncle of carbuncle, Chinese gall can strengthen the defence capability of body to nonspecific stimulation, can strengthen the immunologic function of cell, and this pathogenic bacteria are had to inhibitory action, and can antivirally grow.
The achene of Siberian cocklebur: latin name
xanthii Fructus, taste is pungent, bitter, warm in nature, returns lung channel, has the function of loose wind dehumidifying, understand things pain-stopping, cures mainly nasosinusitis; Anemofrigid headache; Arthralgia due to wind-dampness; Rubella; Eczema; The cards such as mange.Modern pharmacological research confirms that this product has antimicrobial, anti-inflammatory, analgesia, immunosupress, the effect such as anti-oxidant.
Saururus chinensis: latin name
saururi Herba, taste is sweet, pungent, cold in nature, returns lung, urinary bladder channel, has clearing away heat and promoting diuresis; The effect of removing toxicity for detumescence, cures mainly heat and drenches; Blood drenches; Oedema; Beriberi; Jaundice; Dysentery; Under band; Carbuncle sore tumefacting virus; Eczema; The cards such as snake bite.
Selfheal: bitter, pungent, cold in nature, enter liver, gallbladder channel, have and relieve inflammation or internal heat, improving eyesight, dissipating bind, the effect of detumescence, cures mainly red eye, swell pain, and order pearl nyctalgia, has a headache dizzy, scrofula, goiter and tumor, swells and ache; Thyroid gland enlargement, scrofula, the proliferation of mammary gland, the card such as hypertension, hyperglycaemia, high fat of blood and high blood are sticky.
Cape jasmine: latin name
gardeniae fructus, bitter, cold in nature, enter the heart, lung, three warmers, have the effect of relieving restlessness purging intense heat, soothing liver-qi stagnation, clearing heat and promoting diuresis, cooling blood and hemostasis, be mainly used in the strongly fragrant chest gastral cavity of warm heat disease heat vexed uneasiness, bother not peaceful; Liver depression is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, hot eyes dry throat; Jaundice with damp-heat pathogen; The cards such as the abdominal distention of qi depression to blood stasis.
Rde bean: latin name
vignae Semen,taste is sweet, sour, and property is flat, has Li Shui kinds that disappear, and the cards such as red, rheumatic fever numbness, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess are urinated in the effect of detoxify and drain pus for oedema turgor, beriberi edema, jaundice.
Commeline communis: latin name
commelnae Herba,taste is sweet, light, cold in nature, enters the heart, liver,spleen,kidney, intestine and small intestine warp, have clearing heat and detoxicating, the effect of inducing diuresis for removing edema.Cure mainly oedema, beriberi, difficult urination, flu, erysipelas, mumps, icterohepatitis, hot dysentery, malaria, nosebleed epistaxis, hematuria, metrorrhagia, leukorrhea, abscess of throat, the cards such as ulcer furunculosis.
In described Chinese herbal feed additive, the weight portion of each bulk drug is respectively hawthorn 25 weight portion～35 weight portions, Companumoea root 35 weight portion～45 weight portions, suchow mosla herb 20 weight portion～30 weight portions, the root of herbaceous peony 20 weight portion～30 weight portions, parasitic loranthus 35 weight portion～45 weight portions, Chinese yam 55 weight portion～65 weight portions, franzenbach rhubarb root and rhizome 25 weight portion～35 weight portions, Gorgon fruit 30 weight portion～40 weight portions, the vine of multiflower knotweed 25 weight portion～35 weight portions, radix pseudostellariae 70 weight portion～80 weight portions, Radix Liriopes 45 weight portion～55 weight portions, saline cistanche 35 weight portion～45 weight portions, Radix Angelicae Sinensis 35 weight portion～45 weight portions, eclipta 40 weight portion～50 weight portions, adenophora tetraphylla 35 weight portion～45 weight portions, Chinese gall 20 weight portion～30 weight portions, the achene of Siberian cocklebur 35 weight portion～45 weight portions, saururus chinensis 20 weight portion～30 weight portions, selfheal 25 weight portion～35 weight portions, rde bean 35 weight portion～45 weight portions and Commeline communis 20 weight portion～30 weight portions.
Further preferably, in described Chinese herbal feed additive, the weight portion of each bulk drug is respectively hawthorn 28 weight portion～32 weight portions, Companumoea root 38 weight portion～42 weight portions, suchow mosla herb 23 weight portion～27 weight portions, the root of herbaceous peony 23 weight portion～27 weight portions, parasitic loranthus 38 weight portion～42 weight portions, Chinese yam 58 weight portion～62 weight portions, franzenbach rhubarb root and rhizome 28 weight portion～32 weight portions, Gorgon fruit 33 weight portion～37 weight portions, the vine of multiflower knotweed 28 weight portion～32 weight portions, radix pseudostellariae 73 weight portion～77 weight portions, Radix Liriopes 48 weight portion～52 weight portions, saline cistanche 38 weight portion～42 weight portions, Radix Angelicae Sinensis 38 weight portion～42 weight portions, eclipta 43 weight portion～47 weight portions, adenophora tetraphylla 38 weight portion～42 weight portions, Chinese gall 23 weight portion～27 weight portions, the achene of Siberian cocklebur 38 weight portion～42 weight portions, saururus chinensis 23 weight portion～27 weight portions, selfheal 28 weight portion～32 weight portions, rde bean 38 weight portion～42 weight portions and Commeline communis 23 weight portion～27 weight portions.
Most preferably, in described Chinese herbal feed additive, the weight portion of each bulk drug is respectively hawthorn 30 weight portions, Companumoea root 40 weight portions, suchow mosla herb 25 weight portions, the root of herbaceous peony 25 weight portions, parasitic loranthus 40 weight portions, Chinese yam 60 weight portions, franzenbach rhubarb root and rhizome 30 weight portions, Gorgon fruit 35 weight portions, the vine of multiflower knotweed 30 weight portions, radix pseudostellariae 75 weight portions, Radix Liriopes 50 weight portions, saline cistanche 40 weight portions, Radix Angelicae Sinensis 40 weight portions, eclipta 45 weight portions, adenophora tetraphylla 40 weight portions, Chinese gall 25 weight portions, the achene of Siberian cocklebur 40 weight portions, saururus chinensis 25 weight portions, selfheal 30 weight portions, rde bean 40 weight portions and Commeline communis 25 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese herbal feed additive, be specially each bulk drug of described Chinese herbal feed additive is uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, add the water with respect to 4 ~ 6 times of powder qualities, soak 4 ~ 8 hours, then decoct 2 ~ 4 hours, concoction is poured out, again add the water with respect to 2 ~ 4 times of powder qualities, decoct 1 hour ~ 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive.
It is a kind of for improving the feed of carp production performance that the present invention also provides, and its raw material comprises above-mentioned for improving Chinese herbal feed additive, Choline Chloride, inositol, vitamin C, fish meal, dregs of beans, wheat bran, calcium dihydrogen phosphate, dusty yeast, sodium alginate, methionine, threonine, salt, Copper lysinate and the manganese sulfate of carp production performance.
The weight portion of described each raw material is respectively described Chinese herbal feed additive 10 weight portion～20 weight portions, Choline Chloride 0.2 weight portion～0.5 weight portion, inositol 0.2 weight portion～0.5 weight portion, vitamin C 0.2 weight portion～0.5 weight portion, fish meal 35 weight portion～45 weight portions, dregs of beans 20 weight portion～30 weight portions, wheat bran 15 weight portion～25 weight portions, calcium dihydrogen phosphate 1.5 weight portion～2.5 weight portions, dusty yeast 3 weight portion～5 weight portions, sodium alginate 0.5 weight portion～1 weight portion, methionine 0.3 weight portion～0.6 weight portion, threonine 0.3 weight portion～0.6 weight portion, salt 0.5 weight portion～1 weight portion, Copper lysinate 0.1 weight portion～0.3 weight portion, manganese sulfate 0.1 weight portion～0.3 weight portion.
Further, the weight portion of described each raw material is respectively described Chinese herbal feed additive 15 weight portions, Choline Chloride 0.3 weight portion, inositol 0.3 weight portion, vitamin C 0.3 weight portion, fish meal 40 weight portions, dregs of beans 25 weight portions, wheat bran 20 weight portions, calcium dihydrogen phosphate 2 weight portions, dusty yeast 4 weight portions, sodium alginate 0.8 weight portion, methionine 0.5 weight portion, threonine 0.5 weight portion, salt 1 weight portion, Copper lysinate 0.2 weight portion, manganese sulfate 0.2 weight portion.
The present invention also provides the preparation method of above-mentioned feed, is specially:
The first step, prepares described Chinese herbal feed additive according to method above;
Second step, it is even that the Chinese herbal feed additive that the first step is obtained and other each components in described feed are sent into stirrer for mixing in proportion;
The 3rd step, the material mixing carries out modified, and temperature is controlled at 90 ~ 95 ℃, and modulating time 55 ~ 65 seconds is granulated subsequently, and cooling, pellet composition is cooling, and temperature is controlled at 20 ~ 25 ℃, packing.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese herbal feed additive 1
Hawthorn 30g, Companumoea root 40g, suchow mosla herb 25g, root of herbaceous peony 25g, parasitic loranthus 40g, Chinese yam 60g, franzenbach rhubarb root and rhizome 30g, Gorgon fruit 35g, vine of multiflower knotweed 30g, radix pseudostellariae 75g, Radix Liriopes 50g, saline cistanche 40g, Radix Angelicae Sinensis 40g, eclipta 45g, adenophora tetraphylla 40g, Chinese gall 25g, achene of Siberian cocklebur 40g, saururus chinensis 25g, selfheal 30g, rde bean 40g and Commeline communis 25g are uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, the water that adds 4kg, soak 6 hours, then decoct 3 hours, concoction is poured out, the water that again adds 2.5kg, decoct 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive 1.
Embodiment 2 Chinese herbal feed additives 2
Hawthorn 28g, Companumoea root 38g, suchow mosla herb 23g, root of herbaceous peony 23g, parasitic loranthus 38g, Chinese yam 58g, franzenbach rhubarb root and rhizome 28g, Gorgon fruit 33g, vine of multiflower knotweed 28g, radix pseudostellariae 73g, Radix Liriopes 48g, saline cistanche 38g, Radix Angelicae Sinensis 38g, eclipta 43g, adenophora tetraphylla 38g, Chinese gall 23g, achene of Siberian cocklebur 38g, saururus chinensis 23g, selfheal 28g, rde bean 38g and Commeline communis 23g are uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, the water that adds 4kg, soak 6 hours, then decoct 3 hours, concoction is poured out, the water that again adds 2.5kg, decoct 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive 2.
Embodiment 3 Chinese herbal feed additives 3
Hawthorn 32g, Companumoea root 42g, suchow mosla herb 27g, root of herbaceous peony 27g, parasitic loranthus 42g, Chinese yam 62g, franzenbach rhubarb root and rhizome 32g, Gorgon fruit 37g, vine of multiflower knotweed 32g, radix pseudostellariae 77g, Radix Liriopes 52g, saline cistanche 42g, Radix Angelicae Sinensis 42g, eclipta 47g, adenophora tetraphylla 42g, Chinese gall 27g, achene of Siberian cocklebur 42g, saururus chinensis 27g, selfheal 32g, rde bean 42g and Commeline communis 27g are uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, the water that adds 4kg, soak 6 hours, then decoct 3 hours, concoction is poured out, the water that again adds 2.5kg, decoct 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive 3.
Embodiment 4 toxicology tests
Acute toxicity test
With reference to < < medicine registration management way > > and < < Chinese medicine, natural drug studies on acute toxicity technological guidance principle > > requirement, mouse stomach (ig) the administration the acute toxicity tests of the Chinese herbal feed additive 1 of the embodiment of the present invention 1 preparation is as follows: under maximum administration capacity and maximum administration concentration condition, after mouse ig Chinese herbal feed additive 223.9g of the present invention (crude drug)/kg, animal shows the phenomenons such as activity reduces to some extent, gradually recover subsequently normal.Test 40 routine animals without death.After administration, after approximately 1 hour, mouse behavior, movable basic recovery are normally.In the observation period of 14 days, body weight gain is normal afterwards, shows no obvious abnormalities symptom.
Long term toxicity test
With reference to < < medicine registration management way > > and < < Chinese medicine, natural drug long term toxicity investigative technique guideline > > requirement, carried out the long term toxicity test research of rodent SD rat oral gavage administration, result is as follows:
120 of SD rats, test minute high dose group (25.2 (crude drug) g/kg), middle dosage group (14.9g (crude drug)/kg), low dose group (10.2g (crude drug)/kg) and blank group (purified water), 30 of every treated animals, male and female half and half.Method of administration is gastric infusion, and once a day, administration is 6 days weekly, and the test period is 24 weeks.Each test group 1/3 animal should be observed the variation of 4 week convalescence.General status, changes of weight, food ration, blood cytology and biochemical index, gross anatomy and the histopathological examination of animal by the long term toxicity test requirement of new drug, have been observed.
In administration 24 time-of-weeks, it is abnormal that the high, medium and low dosage treated animal of medicine is showed no evident act, and ordinary circumstance is good, during administration without animal dead.Hematology, blood biochemical, prothrombin time, organ coefficient and the Histopathology of 1 month after administration 3 months, 6 months and drug withdrawal checked.Hematology, prothrombin time result show, all find no the Novel presentation relevant to medicine; Blood biochemical is learned result and is shown, the glutamic-pyruvic transaminase of administration animal after 3 months reduces, administration after 6 months creatinine reduce, after administration, sodium, potassium, chlorine ion concentration slightly fluctuate, and recover normal during to convalescence, think this result abiology meaning; Organ coefficient result shows, administration is buck low dose group liver coefficient, Spleen coefficient increase after 6 months, during convalescence, respectively organize each organ coefficient of rat and dirty brain than all in normal range (NR), think that this possibility of result and medicine are relevant through hepatic metabolism, this reaction is reversible with recoverable; Histopathologic examination's result shows, to each important organ of rat, all there is not the pathological change relevant to medicine in this medicine, although each treated animal is degree of taking a favourable turn interstitial lung inflammation all, there is slight fatty liver in indivedual animals, because the pathological change of administration group does not obviously surpass control group, and in conjunction with hematological indices, blood biochemical, learning the experimental results such as index, gross anatomy observation and organ coefficient comprehensively thinks, above-mentioned pathological change and medicine are without obvious correlation, and other each organs and tissues is showed no obvious abnormalities change.
Through to 6 months long term toxicity tests of rat, have no and obviously relevant serious toxicity reaction of medicine, evaluate on the whole, Chinese medicine preparation of the present invention can safety applications in clinical, this medicine non-toxic is 10.2g crude drug/kg.
The preparation of embodiment 5 feeds 1
The Chinese herbal feed additive 1.5kg that embodiment 1 is obtained, Choline Chloride 0.03kg, inositol 0.03kg, vitamin C 0.03kg, fish meal 4kg, dregs of beans 2.5kg, wheat bran 2kg, calcium dihydrogen phosphate 0.2kg, dusty yeast 0.4kg, sodium alginate 0.08kg, methionine 0.05kg, threonine 0.05kg, salt 0.1kg, Copper lysinate 0.02kg, it is even that manganese sulfate 0.02kg sends into stirrer for mixing, the material mixing is carried out modified, temperature is controlled at 95 ℃, modulating time 65 seconds, granulate subsequently, cooling, pellet composition is cooling, temperature is controlled at 20 ℃, packing.
The preparation of comparative example 1 feed 2
By Choline Chloride 0.03kg, inositol 0.03kg, vitamin C 0.03kg, fish meal 4kg, dregs of beans 2.5kg, wheat bran 2kg, calcium dihydrogen phosphate 0.2kg, dusty yeast 0.4kg, sodium alginate 0.08kg, methionine 0.05kg, threonine 0.05kg, salt 0.1kg, Copper lysinate 0.02kg, that manganese sulfate 0.02kg sends into stirrer for mixing is even, the material mixing is carried out modified, temperature is controlled at 95 ℃, modulating time 65 seconds, granulate subsequently, cooling, pellet composition is cooling, temperature is controlled at 20 ℃, packing.
Embodiment 6 raising data
Feed:
Test group adopts the feed 1 of embodiment 5 preparations, and control group adopts the feed 2 of comparative example 1 preparation.
Experiment fish and feeding and management:
Healthy 1 carp in age (No. 3, Beijing) fingerling, is provided by steep River Reservoir culture experiment base.Experiment fish is totally 200 tails, within random minute, supports in 2 aquariums, and adaptability was raised and train after 2 weeks, started experiment.An aquarium is for test group, and another aquarium is for control group, every group of 100 tail carps.Raise 120 d.The water temperature of experimental session, at 19.4 ~ 26.8 ℃, has circulation filter pump and inflator pump, refreshes the water periodically and cleans filter pulp, maintains dissolved oxygen at 5.7 ~ 7. 9 mg/L, and pH value, 6. 1 ~ 8. 0, is controlled ammonia (NH
3) concentration be less than 0. 02 mg/L, control nitrite (NO
2 -) content be less than 0.20 mg/L.
Test on immune function
The mensuration of phagocytic activity of leukocytes
From carp arteria caudalis sterile blood sampling, anticoagulant heparin.Get 0. 25 mL anticoagulations, add 0. 1 mL staphylococcus aureuses (
stapyloccus aureus) suspension (6 * 10
8cFU/mL), 25 ℃ of wet box incubation 1 h pusher blood sheets, after room temperature is dry, methyl alcohol is fixed 3 ~ 4min, alkaline methylene blue dyeing 2 ~ 3min after washing is dry, after washing airing, oily sem observation counting.Be calculated as follows percentage phagocytosis (phago-cytosis percentage, PP) and phagocytic index (phagocytic index, PI).
In percentage phagocytosis (PP)=100 leucocyte, participate in cell number/100 * 100% of engulfing
The bacterial population of phagocytic index (PI)=engulfed/the engulf cell number of bacterium
The mensuration of lysozyme activity
With micrococcus lysodeikticus (
micrococcus lysodeikticus) freeze-dried powder (sigma company product) is substrate, with the phosphate buffer (PBS) of 0. 1 mol/L, pH 6. 4, is made into certain density substrate bacteria suspension (OD
570≈ 0. 3), get 1. 5 mL substrate bacteria suspensions and mix in test tube with 25 μ L test serums, survey its A0 value.Then test solution is moved in 37 ℃ of water-baths and is incubated 30 min.After taking-up, be placed in immediately ice bath 10 min, with cessation reaction, survey its A value.Antalzyme activity is calculated as follows: U=(A
0-A)/A, U is antalzyme activity; A
0for reacting front optical density; A is the rear optical density of reaction.
The mensuration that hepatocuprein (SOD) is active
With xanthine oxidase, Bioengineering Research Institute's product is built up in Nanjing.
Statistical disposition
Experimental data represents with " average ± standard error ", difference statistics between organizing with t check.
Result
The impact of carp phagocytic activity of leukocytes, the results are shown in Table 1.
The impact of table 1 carp phagocytic activity of leukocytes
| Group | Test fish/tail | Percentage phagocytosis (PP)/% | Phagocytic index (PI) |
| Test group | 100 | 45.28±2.31 | 3.76±0.51 |
| Control group | 100 | 25.31±2.03 | 1.21±0.23 |
Phagocyte in animal body can be engulfed the foreign matter entering in body, in the nospecific immunity of animal, plays a significant role.Phagocyte, in digestion pathogenic microorganism, can retain relevant antigenic information and be passed to relevant lymphocyte, thereby the humoral immunity of excitating organism and cellular immunity is the important component part of animal body nospecific immunity.As can be seen from Table 1, test group and control group comparison, leukocytes phagocytic percentage (PP) and phagocytic index (PI) are all obviously high, P<0.05.
The impact of Serum of Common Carp lysozyme and SOD vigor, the results are shown in Table 2.
The impact of table 2 Serum of Common Carp lysozyme and SOD vigor
| Group | Test fish/tail | Lysozyme/10 －3U | SOD/10 3U·L -1 |
| Test group | 100 | 216.53±22.17 | 169.29±13.11 |
| Control group | 100 | 163.59±13.93 | 110.31±10.93 |
Lysozyme is a kind of hydrolase, fish, is mainly present in mucus, serum, neutrophil leucocyte, monocyte and macrophage.Lysozyme is killed by the mucopolysaccharide in enzymolysis pathogenic microorganism cell membrane, is the important component part of fish nospecific immunity system.Level and the activity of lysozyme in fish body, be directly connected to immunologic function and the health of fish.
Hepatocuprein (SOD) is one of key enzyme of Antioxidant Enzymes in body, and its major function is to remove the ultra-oxygen anion free radical producing in body.In body, the height of SOD activity has reflected the size of organ-tissue anti-oxidation protection ability; immunologic function to the defence capability of macrophage and whole body has material impact; being used for passing judgment on the impact of immunomodulator on body's immunity, is also an important indicator weighing organism health status.
The serum lysozyme of test group and serum activity of SOD are obviously higher compared with control group, P<0.05.
As can be seen from Table 1 and Table 2, adopt Chinese herbal feed additive provided by the invention can obviously improve the immunologic function of carp.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. for improving a Chinese herbal feed additive for carp immunologic function, it is characterized in that: bulk drug comprises hawthorn, Companumoea root, suchow mosla herb, the root of herbaceous peony, parasitic loranthus, Chinese yam, franzenbach rhubarb root and rhizome, Gorgon fruit, the vine of multiflower knotweed, radix pseudostellariae, Radix Liriopes, saline cistanche, Radix Angelicae Sinensis, eclipta, adenophora tetraphylla, Chinese gall, the achene of Siberian cocklebur, saururus chinensis, selfheal, rde bean and Commeline communis.
2. Chinese herbal feed additive as claimed in claim 1, is characterized in that: the weight portion of each bulk drug is respectively hawthorn 25 weight portion～35 weight portions, Companumoea root 35 weight portion～45 weight portions, suchow mosla herb 20 weight portion～30 weight portions, the root of herbaceous peony 20 weight portion～30 weight portions, parasitic loranthus 35 weight portion～45 weight portions, Chinese yam 55 weight portion～65 weight portions, franzenbach rhubarb root and rhizome 25 weight portion～35 weight portions, Gorgon fruit 30 weight portion～40 weight portions, the vine of multiflower knotweed 25 weight portion～35 weight portions, radix pseudostellariae 70 weight portion～80 weight portions, Radix Liriopes 45 weight portion～55 weight portions, saline cistanche 35 weight portion～45 weight portions, Radix Angelicae Sinensis 35 weight portion～45 weight portions, eclipta 40 weight portion～50 weight portions, adenophora tetraphylla 35 weight portion～45 weight portions, Chinese gall 20 weight portion～30 weight portions, the achene of Siberian cocklebur 35 weight portion～45 weight portions, saururus chinensis 20 weight portion～30 weight portions, selfheal 25 weight portion～35 weight portions, rde bean 35 weight portion～45 weight portions and Commeline communis 20 weight portion～30 weight portions.
3. Chinese herbal feed additive as claimed in claim 1 or 2, is characterized in that: the weight portion of each bulk drug is respectively hawthorn 28 weight portion～32 weight portions, Companumoea root 38 weight portion～42 weight portions, suchow mosla herb 23 weight portion～27 weight portions, the root of herbaceous peony 23 weight portion～27 weight portions, parasitic loranthus 38 weight portion～42 weight portions, Chinese yam 58 weight portion～62 weight portions, franzenbach rhubarb root and rhizome 28 weight portion～32 weight portions, Gorgon fruit 33 weight portion～37 weight portions, the vine of multiflower knotweed 28 weight portion～32 weight portions, radix pseudostellariae 73 weight portion～77 weight portions, Radix Liriopes 48 weight portion～52 weight portions, saline cistanche 38 weight portion～42 weight portions, Radix Angelicae Sinensis 38 weight portion～42 weight portions, eclipta 43 weight portion～47 weight portions, adenophora tetraphylla 38 weight portion～42 weight portions, Chinese gall 23 weight portion～27 weight portions, the achene of Siberian cocklebur 38 weight portion～42 weight portions, saururus chinensis 23 weight portion～27 weight portions, selfheal 28 weight portion～32 weight portions, rde bean 38 weight portion～42 weight portions and Commeline communis 23 weight portion～27 weight portions.
4. the preparation method of the Chinese herbal feed additive as described in claims 1 to 3, it is characterized in that: each bulk drug of described Chinese herbal feed additive is uniformly mixed, send in pulverizer and pulverize, be screened into 20 object powder, put into subsequently saucepan, add the water with respect to 4 ~ 6 times of powder qualities, soak 4 ~ 8 hours, then decoct 2 ~ 4 hours, concoction is poured out, again add the water with respect to 2 ~ 4 times of powder qualities, decoct 1 hour ~ 2 hours, filter, the concoction obtaining and the concoction obtaining above mixing will be filtered, reduced pressure concentration is except anhydrating, dry, pulverize, be screened into 20 object powder, obtain described Chinese herbal feed additive.
5. for improving a feed for carp production performance, it is characterized in that: raw material comprises Chinese herbal feed additive, Choline Chloride, inositol, vitamin C, fish meal, dregs of beans, wheat bran, calcium dihydrogen phosphate, dusty yeast, sodium alginate, methionine, threonine, salt, Copper lysinate and the manganese sulfate for improving carp production performance.
6. feed as claimed in claim 5, is characterized in that: the bulk drug of described Chinese herbal feed additive comprises hawthorn, Companumoea root, suchow mosla herb, the root of herbaceous peony, parasitic loranthus, Chinese yam, franzenbach rhubarb root and rhizome, Gorgon fruit, the vine of multiflower knotweed, radix pseudostellariae, Radix Liriopes, saline cistanche, Radix Angelicae Sinensis, eclipta, adenophora tetraphylla, Chinese gall, the achene of Siberian cocklebur, saururus chinensis, selfheal, rde bean and Commeline communis.
7. the feed as described in claim 5 or 6, is characterized in that: the weight portion of each bulk drug of described Chinese herbal feed additive is respectively hawthorn 25 weight portion～35 weight portions, Companumoea root 35 weight portion～45 weight portions, suchow mosla herb 20 weight portion～30 weight portions, the root of herbaceous peony 20 weight portion～30 weight portions, parasitic loranthus 35 weight portion～45 weight portions, Chinese yam 55 weight portion～65 weight portions, franzenbach rhubarb root and rhizome 25 weight portion～35 weight portions, Gorgon fruit 30 weight portion～40 weight portions, the vine of multiflower knotweed 25 weight portion～35 weight portions, radix pseudostellariae 70 weight portion～80 weight portions, Radix Liriopes 45 weight portion～55 weight portions, saline cistanche 35 weight portion～45 weight portions, Radix Angelicae Sinensis 35 weight portion～45 weight portions, eclipta 40 weight portion～50 weight portions, adenophora tetraphylla 35 weight portion～45 weight portions, Chinese gall 20 weight portion～30 weight portions, the achene of Siberian cocklebur 35 weight portion～45 weight portions, saururus chinensis 20 weight portion～30 weight portions, selfheal 25 weight portion～35 weight portions, rde bean 35 weight portion～45 weight portions and Commeline communis 20 weight portion～30 weight portions.
8. the feed as described in claim 5 to 7, it is characterized in that: the weight portion of described each raw material is respectively described Chinese herbal feed additive 10 weight portion～20 weight portions, Choline Chloride 0.2 weight portion～0.5 weight portion, inositol 0.2 weight portion～0.5 weight portion, vitamin C 0.2 weight portion～0.5 weight portion, fish meal 35 weight portion～45 weight portions, dregs of beans 20 weight portion～30 weight portions, wheat bran 15 weight portion～25 weight portions, calcium dihydrogen phosphate 1.5 weight portion～2.5 weight portions, dusty yeast 3 weight portion～5 weight portions, sodium alginate 0.5 weight portion～1 weight portion, methionine 0.3 weight portion～0.6 weight portion, threonine 0.3 weight portion～0.6 weight portion, salt 0.5 weight portion～1 weight portion, Copper lysinate 0.1 weight portion～0.3 weight portion, manganese sulfate 0.1 weight portion～0.3 weight portion.
9. the preparation method of feed described in claim 5 to 8, is characterized in that:
The first step, prepares described Chinese herbal feed additive in accordance with the method for claim 4;
Second step, it is even that the Chinese herbal feed additive that the first step is obtained and other each components in described feed are sent into stirrer for mixing in proportion;
The 3rd step, the material mixing carries out modified, and temperature is controlled at 90 ~ 95 ℃, and modulating time 55 ~ 65 seconds is granulated subsequently, and cooling, pellet composition is cooling, and temperature is controlled at 20 ~ 25 ℃, packing.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104286596A (en) * | 2014-11-11 | 2015-01-21 | 济南凯因生物科技有限公司 | Feed for carp in breeding season |
| CN105941858A (en) * | 2016-07-07 | 2016-09-21 | 山东新希望六和集团有限公司 | Winter carp feed additive |
| CN106387509A (en) * | 2016-09-23 | 2017-02-15 | 广州市联鲲生物科技有限公司 | Fish feed additive |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104286596A (en) * | 2014-11-11 | 2015-01-21 | 济南凯因生物科技有限公司 | Feed for carp in breeding season |
| CN105941858A (en) * | 2016-07-07 | 2016-09-21 | 山东新希望六和集团有限公司 | Winter carp feed additive |
| CN106387509A (en) * | 2016-09-23 | 2017-02-15 | 广州市联鲲生物科技有限公司 | Fish feed additive |
| CN106421014A (en) * | 2016-10-31 | 2017-02-22 | 通化师范学院 | Feed additive composition for cold water fish and application thereof |
| CN106562111A (en) * | 2016-11-02 | 2017-04-19 | 通化师范学院 | Traditional Chinese herbal feed additive composition for oncorhynchus mykiss, as well as preparation method and application thereof |
| CN106387514A (en) * | 2016-11-22 | 2017-02-15 | 防城港市海洋局 | Traditional Chinese medicine feed additive for fish and preparation method thereof |
| CN106819626A (en) * | 2016-12-20 | 2017-06-13 | 新昌县润普水产科技有限公司 | A kind of feed of grass carp easy to digest and preparation method thereof |
| CN106974136A (en) * | 2017-05-05 | 2017-07-25 | 山东百福生物科技有限公司 | A kind of feed addictive for improving fancy carp muscle of back thickness and its application |
| CN108077125A (en) * | 2017-12-26 | 2018-05-29 | 广西金海环岛渔业有限公司 | Improve the cultural method of Tilapia mossambica oxidation resistance |
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