CN102805275B - Feed and traditional Chinese medicine compound used for treating colibacillosis of chicken and preparation method of feed and traditional Chinese medicine compound - Google Patents
Feed and traditional Chinese medicine compound used for treating colibacillosis of chicken and preparation method of feed and traditional Chinese medicine compound Download PDFInfo
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Abstract
The invention discloses feed and a traditional Chinese medicine compound used for treating colibacillosis of a chicken, and a preparation method of the feed and the traditional Chinese medicine compound. The feed comprises a feed carrier and the traditional Chinese medicine compound, and the traditional Chinese medicine compound comprises rhizoma coptidis, Chinese pulsatilla root, frankincense, cape jasmine, rhizoma anemarrhenae, radix trichosanthis, angelica sinensis, radix paeoniae rubra, carbonied sanguisorba root, myrobalan, cortex cinnamomi, akebiaquinata, radix isatidis, rhizoma cyperi,herba agastachis, placenta hominis, radix glycyrrhizae, radish seeds and haws. The feed, the traditional Chinese medicine compound and the preparation method have the benefits that compared with the traditional feed, when the feed containing the traditional Chinese medicine compound is used to raise the sick chicken, the traditional Chinese medicine compound coordinates with the feed carrier, so that the normal nutritional requirements of the chicken are met, and the effects on preventing and treating the colibacillosis of the chicken are significant as well; and the cure rate is high withouttoxic or side effects.
Description
Technical field
The present invention relates to technical field of animal, particularly a kind of feed, Chinese medicine composition and preparation method who is used for the treatment of chicken colibacillosis.
Background technology
Chicken colibacillosis is a kind of common frdquently encountered disease that is caused by Escherichia coli.Comprising multiple diseases such as escherichia coli peritonitis, salpingitis, omphalitis, synovitis, air bag inflammation, granuloma, ophthalmias, bigger to poultry husbandry harm.Intensive poultry is after main eqpidemic disease obtains basic controlling, and colibacillosis has tangible ascendant trend, has become one of harm chicken group main bacteria disease, should cause enough attention.Escherichia coli are in natural environment, and the body surface of feed, drinking-water, chicken, hatchery, incubator etc. are ubiquity everywhere, this bacterium in kind of an egg surface, egg, in the hatching process dead germ and hair liquid in separation rate higher, therefore constituted the threat of poultry overall process.This disease all can take place chick stage, finishing period and adult laying hen, chick is the acute sepsis process, turkey is then based on subacute or chronic infection, in most cases because being subjected to the influence of various stress factor and other disease, this disease infects even more serious, and adult laying hen is often opening the generation of product stage, and death rate increases, influence is laid eggs, and production performance can not be given full play to.Kind of chicken house generation chicken colibacillosis directly has influence on hatching of breeding eggs rate, chickling-surviving rate, causes that dead germ and a hair egg increase in the hatching process, and strong young rate is low.This disease all can take place throughout the year, annual rainy, sultry, wet season is multiple.
Prevent and treat in this sick process at the employing Western medicine in recent years and find that Escherichia coli very easily develop immunity to drugs to medicine, the drug resistance of chicken pathogenic escherichia coli is extremely extensively propagated rapidly, makes chicken colibacillosis rise to one of the most thorny disease of harm aquaculture.Almost there is not therapeutic action as antibiotic such as penicillin, streptomysin, terramycin, tetracyclines, though and chloramphenicol, gentamicin, orfloxacin, neomycin have better therapeutic effect, but the bacterial strain that these medicines develop immunity to drugs has been occurred and the trend of increasing arranged, in addition, these chemicalses obviously can cause the chicken drug disposition residual, and then influence human and livestock health even harm public health.
At present, the Chinese medicine that some treatment chicken colibacillosis occurred, compare with Western medicine such as above-mentioned antibiotic, though have cheap advantage, but its result for the treatment of and produce effects speed are very slow, longer a period of time just can make transference cure after taking medicine, so still can not thoroughly eliminate the problem of medicament residue.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of feed that comprises the Chinese medicine composition that is used for the treatment of chicken colibacillosis, the feed that employing contains this Chinese medicine composition can overcome the defective of prior art Chinese and Western medicine and Chinese medicine, to the chicken that suffers from chicken colibacillosis have evident in efficacy, cure rate is high, have no side effect, do not have poisoning, be difficult for recurrence, advantage that cost is low.
In order to realize the foregoing invention purpose, the invention provides a kind of feed that is used for the treatment of chicken colibacillosis, comprise feed vector and Chinese medicine composition, described Chinese medicine composition comprises the coptis, the Chinese bulbul, frankincense, cape jasmine, the wind-weed, root of Chinese trichosanthes, Radix Angelicae Sinensis, the radix paeoniae rubrathe, charred RADIX SANGUISORBAE, myrobalan, Chinese cassia tree, akebi, Radix Isatidis, rhizoma cyperi, wrinkled giant hyssop, dried human placenta, Radix Glycyrrhizae, radish seed and hawthorn.
Described feed vector comprises corn, dregs of beans, composite bacillus and yucconin.
The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: the 1-5 weight portion.
The ratio of weight and number of various components is in the described Chinese medicine composition: coptis 20-45 part, Chinese bulbul 25-35 part, frankincense 15-25 part, cape jasmine 14-27 part, wind-weed 10-20 part, root of Chinese trichosanthes 10-25 part, Radix Angelicae Sinensis 20-35 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 15-25 part, myrobalan 10-25 part, Chinese cassia tree 10-35 part, akebi 15-25 part, Radix Isatidis 10-35 part, rhizoma cyperi 10-20 part, wrinkled giant hyssop 20-35 part, dried human placenta 10-20 part, Radix Glycyrrhizae 20-35 part, radish seed 10-15 part and hawthorn 15-35 part.
The ratio of weight and number of various components is in the described Chinese medicine composition: coptis 25-40 part, Chinese bulbul 25-30 part, frankincense 18-22 part, cape jasmine 18-24 part, wind-weed 13-18 part, root of Chinese trichosanthes 17-20 part, Radix Angelicae Sinensis 25-30 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 18-21 part, myrobalan 15-20 part, Chinese cassia tree 15-30 part, akebi 18-22 part, Radix Isatidis 17-30 part, rhizoma cyperi 12-18 part, wrinkled giant hyssop 26-30 part, dried human placenta 12-17 part, Radix Glycyrrhizae 25-30 part, radish seed 10-14 part and hawthorn 25-30 part.
The ratio of weight and number of various components is preferably in the described Chinese medicine composition: 27 parts of 32 parts of the coptiss, 27 parts of the Chinese bulbuls, 20 parts of frankincenses, 20 parts of cape jasmines, 15 parts of the wind-weeds, 18 parts of roots of Chinese trichosanthes, 26 parts of Radix Angelicae Sinensis, 23 parts of the radix paeoniae rubrathe, 19 parts of charred RADIX SANGUISORBAEs, 17 parts of myrobalans, 21 parts of Chinese cassia trees, 20 parts of akebis, 25 parts of Radix Isatidis, 14 parts of rhizoma cyperis, 28 parts of wrinkled giant hyssops, 15 parts of dried human placentas, 27 parts in Radix Glycyrrhizae, 12 parts of radish seeds and hawthorn.
The preparation method of described Chinese medicine composition can for: take by weighing all Chinese medicine material mixed grindings according to percentage by weight and become 150-200 order fine powder, be prepared into described Chinese medicine additive, the grinding particle size of bulk drug is 2-5mm, makes its fine powder amount reach more than 92% of the total material of Chinese medicine additive.
The ratio of weight and number of each component is in the described feed vector: corn 40-65 part, dregs of beans 20-45 part, composite bacillus 0.1-0.5 part and yucconin 0.01-0.08 part.
The ratio of weight and number of each component is preferably in the described feed vector: 0.07 part of 55 parts of corns, 25 parts of dregs of beans, 0.4 part of composite bacillus and yucconin.
The ratio of weight and number of each component can also be preferably in the described feed vector: 0.05 part of 50 parts of corns, 30 parts of dregs of beans, 0.35 part of composite bacillus and yucconin.
Described composite bacillus is one or more in bacillus subtilis, bacillus licheniformis and the bacillus cereus.
The present invention also provides a kind of preparation method who is used for the treatment of the feed of chicken colibacillosis, and described preparation method comprises:
(1) take by weighing corn and dregs of beans according to ratio of weight and number, be ground into 150-200 purpose powder after mixing, 120-140 ℃ temperature bottom fermentation 4-7 days, the oven dry and be ground into powder under 60-70 ℃ of temperature of fermentation back;
(2) take by weighing composite bacillus, yucconin and Chinese medicine composition according to ratio of weight and number, and with described step (1) in after the powder that obtains fully mixes, drop into granulator and granulate, pelleting temperature is 75-80 ℃, obtains pellet;
(3) pellet that obtains in the described step (2) is spread on the ebullated bed of boiling drier, heat drying 10-15 minute, the import wind-warm syndrome of heating degree was 120-130 ℃, obtained the dried granules feed.
A kind for the treatment of is used for the treatment of the Chinese medicine composition of chicken colibacillosis, comprises the bulk drug of following ratio of weight and number in the Chinese medicine composition: coptis 25-40 part, Chinese bulbul 25-30 part, frankincense 18-22 part, cape jasmine 18-24 part, wind-weed 13-18 part, root of Chinese trichosanthes 17-20 part, Radix Angelicae Sinensis 25-30 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 18-21 part, myrobalan 15-20 part, Chinese cassia tree 15-30 part, akebi 18-22 part, Radix Isatidis 17-30 part, rhizoma cyperi 12-18 part, wrinkled giant hyssop 26-30 part, dried human placenta 12-17 part, Radix Glycyrrhizae 25-30 part, radish seed 10-14 part and hawthorn 25-30 part.
The preparation method who is used for the treatment of the Chinese medicine composition of chicken colibacillosis comprises:
The first step, each component in the described Chinese medicine composition is mixed in proportion, and the input pulverizer is pulverized or directly chopping, and packing into decocts in the container, add suitable quantity of water and make its submergence medicinal material, soak after 10-25 minute, be heated to boiling after 40-70 minute, separate fried liquid, the dregs of a decoction add water again and decoct 2-3 time, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again;
Second step, treat filtrate cooling after, adding with respect to concentrating back liquid weight 1-2 determining alcohol doubly is 80-90% ethanol, fully mix, placement is spent the night, and makes its precipitation, obtain filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing lotion and merges with filtrate, after ethanol was regained in decompression, dislocation was put cold place, leaves standstill 0.5-1 hour, make precipitation fully, filter, the filtrate low-temperature evaporation obtains paste;
The 3rd step: it is dry that paste is put into spray dryer, guarantees EAT at 180 ℃-200 ℃, and 70 ℃-90 ℃ of leaving air temps are ground into 300 orders-400 order subsequently, obtain Powdered Chinese medicine composition.
The beneficial effect that technical scheme provided by the invention is brought is: compare with conventional feed, use contains the ill chicken of forage feed of Chinese medicine composition of the present invention, the effect of cooperatively interacting of Chinese medicine composition and feed vector, not only guarantee the normal nutritional need of chicken, and the effect of prevention and treatment chicken colibacillosis is remarkable, cure rate is high, have no side effect; Chinese medicine composition of the present invention to prevention and the treatment of the chicken that suffers from chicken colibacillosis have efficiently, have no side effect, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, effect rapid, cheap, have an advantage of applying.
The specific embodiment
But the chicken at various ages is the infected chicken colibacillosis all, but because of the effect of feeding and management level, environmental sanitation, prophylactico-therapeutic measures, has or not the influence of factors such as other eqpidemic disease of secondary, and this sick M ﹠ M has larger difference.Intensive poultry is after main eqpidemic disease obtains basic controlling, and colibacillosis has tangible ascendant trend, has become one of harm chicken group main bacteria disease.
Chicken colibacillosis does not have the clinical manifestation of feature, but with chicken morbidity age in days, course of disease length, the histoorgan of being encroached on and position, have or not secondary or mixed infection that much relations are arranged.
(1) nascent chick omphalitis is commonly called as " big navel ".Wherein most relevant with Escherichia coli.Sick young spirit is depressed, lacks and eats or do not eat, and belly is big, and umbilical opening and surrounding skin thereof are rubescent, oedema.This kind disease is young how dead or superseded in a week.Another kind shows as diarrhea, except spirit, appetite is poor, as seen releases earth sample ight soil, and is dead in sick young 1-2 days.Death loses obvious peak.
(2) between brood time comprising the colibacillosis of broiler, primary infection is fewer more rare, is mostly because due to scabies secondary infection and the mixed infection.Especially work as in the process of chick stage generation Bursal Disease, or cause that because feeding and management is improper the chicken chronic respiratory disease has this disease to take place often.Sick chicken feed desire descends, spirit is depressed, feather loose random, she has loose bowels.Have the symptom of other disease simultaneously concurrently.It is roughly similar to breed the chicken incidence.
(3) the stage chicken mass-sending of laying eggs is sick, and how extensive by feeding and management, environmental pollution is serious, or takes place rainy sultry season on the occasion of humidity.This situation is generally based on primary infection.Can be secondary in addition in the process of other disease such as white diarrhea, ewcastle disease, infective bronchitis, infectious laryngotracheitis and chronic respiratory disease generation.It is not high mainly to show as egg production, and the peak of laying eggs does not increase, the peak of the laying eggs weak point of holding time, and chicken group death rate increases.Sick chicken clinical manifestation is just like degradation performance under cockscomb atrophy, diarrhea, the appetite.
Pathology cuts open inspection to be changed: nascent chick omphalitis is visible umbilical opening surrounding skin oedema, ecchymoma, hemorrhage, oedema after death, and edematous fluid is faint yellow or yellowish red color.Umbilical opening is opened a business, and newborn young die of illness chicken and omphalitis based on the diarrhea chicken that causes death all can be seen yolk and do not absorb or malabsorption, and egg capsule hyperemia, hemorrhage, the interior yolk liquid thickness or thin of capsule are yellow green more.Enteron aisle is catarrhal inflammation.The faint yellow necrosis region that is dispersed in is seen in the liver enlargement sometimes, and Glisson's capsule slightly thickens.The chicken that dies of illness with Mycoplasma mixed infection sees hepatosplenomegaly more, and Glisson's capsule thickens, and the opaque yellow-white that is easily strips off.The part that is that this fiber disposition film that forms on the liver surface has takes place, and serious whole liver surface is wrapped up by this film, and this film strips off the back liver and is puce; Pericarditis, pericardial thickening is opaque, and pericardium amasss weak yellow liquid; The air bag inflammation also is common variation, and air bag cyst walls such as chest, abdomen thicken and are lark, fibrinous exudate that quantity do not wait or cheesy thing is arranged as yolk in the blister cavities.The visible salpingitis of the chicken that dies of illness that has, mucous hyperemia has the cheesy thing of inequality in the tube chamber, and the fallopian tubal inner product has relatively large shape thing when serious, the tubal wall attenuation, block is yellow-white, and tangent plane wheel stratiform is dry.See in the abdominal cavity that has that it is linen soft-shelled egg that outward appearance is arranged.More adult chicken also sees lecithality peritonitis, and seeing in the abdominal cavity has egg yolk liquid to be distributed in the enteron aisle surface widely.There is volume cellulose sample thing to be bonded on enteron aisle and the mesenterium in the slow slightly dead chicken abdominal cavity, peritoneal inflammation, peritoneal inflammation, peritonaeum is coarse, the visible intestinal adhesion that has.The escherichia coli granuloma is less to be seen.Small intestine, caecum serous coat and mesenterium can be seen the granuloma tubercle, and intestinal adhesion is not easily separated, liver then shows as necrosis region not of uniform size, that quantity does not wait.Other just can be seen in this sick generating process sometimes as ophthalmia, synovitis, pneumonia etc.
The invention provides a kind of Chinese medicine composition for the treatment of chicken colibacillosis, comprise the coptis, the Chinese bulbul, frankincense, cape jasmine, the wind-weed, root of Chinese trichosanthes, Radix Angelicae Sinensis, the radix paeoniae rubrathe, charred RADIX SANGUISORBAE, myrobalan, Chinese cassia tree, akebi, Radix Isatidis, rhizoma cyperi, wrinkled giant hyssop, dried human placenta, Radix Glycyrrhizae, radish seed and hawthorn.Wherein, Chinese medicine composition preferably only is made of said components.
The ratio of weight and number of various components is preferably in the Chinese medicine composition: coptis 20-45 part, Chinese bulbul 25-35 part, frankincense 15-25 part, cape jasmine 14-27 part, wind-weed 10-20 part, root of Chinese trichosanthes 10-25 part, Radix Angelicae Sinensis 20-35 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 15-25 part, myrobalan 10-25 part, Chinese cassia tree 10-35 part, akebi 15-25 part, Radix Isatidis 10-35 part, rhizoma cyperi 10-20 part, wrinkled giant hyssop 20-35 part, dried human placenta 10-20 part, Radix Glycyrrhizae 20-35 part, radish seed 10-15 part and hawthorn 15-35 part.
Wherein, in the Chinese medicine composition, the coptis, the Chinese bulbul and cape jasmine have heat-clearing and damp-drying drug, purging intense heat and detonicating, clearing heat and detoxicating; Frankincense, Radix Angelicae Sinensis and dried human placenta regulating the qi flowing in the channels are enriched blood and are invigorated blood circulation, analgesic therapy; Root of Chinese trichosanthes, wind-weed nourishing yin and purging fire, clearing heat and cooling blood, the radix paeoniae rubrathe and charred RADIX SANGUISORBAE promoting blood circulation and hemostasis; The myrobalan has convergence, anti-diarrhea effect; Dampness removing in Chinese cassia tree and the akebi temperature; Radix Isatidis suppresses the Escherichia coli bacterium; Rhizoma cyperi has the effect of alleviating the distending pain in hypochondrium, the full pain of gastral cavity abdomen ruffian; The wrinkled giant hyssop appetizing of being amusing; Radish seed and hawthorn digesting stomach invigorating promote ill chicken to eliminate eating accumulation, promote to digest and assimilate; The Radix Glycyrrhizae coordinating the drug actions of a prescription; All medicines share, and improve resistance against diseases and immunologic function, the effect of playing relieving the exterior syndrome with drugs pungent in flavor and warm in property, heat-clearing toxin expelling, clearing Ying heat and cooling blood altogether.
The pharmacology of described each component is as follows:
The coptis: bitter, cold in nature, go into the heart, lung, courage, stomach, large intestine channel, heat-clearing and damp-drying drug is arranged, purging intense heat and detonicating, the effect of cooling blood for improving eyesight, it is full to cure mainly damp and hot ruffian, and the vomiting acid regurgitation rushes down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head is told nosebleed, hot eyes, toothache is quenched one's thirst, the carbuncle furunculosis that swells, eczema, wet sore, duct card such as suppurate, the coptis is light broad spectrum antiviral drug thing, can effectively reduce the drug resistance of salmonella, to staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumonia, meningococcus, shigella dysenteriaes etc. have stronger bacteriostasis, amplification on Canon of Materia Medica: how moderns are with controlling dysentery, and lid is held with the dry justice of hardship.Down valgar but see that intestines void is oozed and let out, little seemingly have a bloody stool, namely uses it, more do not know to end.Ignore again fever and chills what, but with most agent degree of being, by being that to cause danger tired more.If gas is real just sick, hot many bloody flux, just ending of clothes still needn't be use up agent also.Or empty and cold, then must not obey.Surplus as " warp ".
The Chinese bulbul: bitter, cold in nature; Return stomach, large intestine channel; Have clearing heat and detoxicatingly, remove heat from the blood and relieve diarrhea the effect of removing dampness and destroying parasites; Cure mainly the pyrotoxic dysentery disease, nosebleed epistaxis, bleeding, band down, pruritus vulvae, the carbuncle sore, scrofula antibacterial action: the bright juice of the Chinese bulbul, decoction, ethanol extract equals the external tangible antibacterial action that all has, can suppress staphylococcus aureus, Pseudomonas aeruginosa, shigella dysenteriae, hay bacillus, typhoid bacillus, the growth of detection of Salmonella etc. Anemonin is to corynebacterium diphtheriae, staphylococcus, streptococcus, Escherichia coli, tubercle bacillus acts in addition, and the Chinese bulbul and compound thereof such as baitouweng decoction are to dermatophyte, saccharomycete, trypanosome, Candida albicans etc. all have inhibitory action. and the Chinese bulbul have the stronger fungi effect of killing.The Chinese bulbul also has slight inhibitory action to the small white mouse influenza infection, and its infusion can prolong the time-to-live of influenza virus infection PR8 strain mouse, alleviates lung inflammation. and Chinese bulbul ethanol extract has calmness, analgesic activity.
Frankincense: flavor is hot, and heat is gone into the heart, liver, the spleen channel, regulating qi and activating blood, analgesic therapy is arranged, chase after malicious effect.Control qi and blood stagnation, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhoea, postpartum blood stasis shouting pain." new compilation of materia medica ": control demented, stopping leak dysentery." book on Chinese herbal medicine converges and says ": frankincense, the wind of invigorating blood circulation, the medicine of Shujin pain relieving is also.Chen Shi invention cloud, perfume is strong walks to scurry, so go into ulcer section, the side is with extremely many.Falling again beats beats, folding injury of the tissues bone, postpartum, qi and blood was attacked thorn again, trusted subordinate's pain permanently use this, salty its fragrant suffering of getting is wandered away, the blood apocenosis of loosing, ventilationization is stagnant be special merit also.So large carbuncle can be managed, folding is hindered and can be continued, and postpartum blood stasis is detained feasible, disease piece mass in the abdomen, and the cold lump in the abdomen of volt blood can be gone, and property pathogenic dryness is strong, goes wind to invigorate blood circulation, and chases after malicious analgesic therapy, except large carbuncle, postpartum and injury of the tissues bone, neither must using.
Cape jasmine: bitter, cold in nature, go into the heart, lung, three warmers, the effect of relieving restlessness purging intense heat, soothing liver-qi stagnation, clearing heat and promoting diuresis, cooling blood and hemostasis is arranged, be mainly used in the strongly fragrant chest gastral cavity of warm heat disease heat vexed uneasiness, bother not peaceful; What liver depression was not relaxed or Liver Channel has heat has a dizzy spell pain in chest and hypochondrium, hot eyes dry throat; Jaundice with damp-heat pathogen; Symptoms such as the abdominal distention of qi depression to blood stasis, the heat conduction of cape jasmine tonneau three warmers is descending, and anti-hepatic lesion effect is arranged.
The wind-weed: bitter, sweet, cold.Return lung, stomach, kidney channel.The effect that has clearing heat-fire, promotes the production of body fluid and moisturize.Shennong's Herbal: main quenching one's thirst pined for, except perverse trend limbs edema, and following water, tonifying for the deficiency, beneficial gas." Mingyi Bielu ": the cold chronic malaria dysphoria with smothery sensation of curing the wound, the side of body is perverse trend down, dislikes in the diaphragm and the interior subcutaneous ulcer of wind sweat." property of medicine opinion ": cure mainly vexed hot-tempered vexedly, general debility during puerperium is given birth in the contact of the hot labor of bone, kidney qi labor, and the loathing of cold is deficient, suffers from people's void and dry, adds and uses it.
Root of Chinese trichosanthes: sweet, little hardship is slightly cold.Attach to the lung and stomach meridians.Effect with clearing heat and promoting fluid, detumescence and apocenosis.Be used for the pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin.Root of Chinese trichosanthes is joined the wind-weed, and nourishing yin and purging fire promotes the production of body fluid to quench thirst, the polydipsia for the treatment of consumption of body fluid caused by febrile disease and the diabete that lung and stomach excessive heat is hindered Tianjin.
Radix Angelicae Sinensis: distinguish the flavor of sweet and weigh, so specially can enrich blood, its gas is light and hot, thus again can promoting circulation of blood, and bowl spares has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the tonifying Qi production of sperm, five viscera settling, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain defaecation of dispelling, relieving rigidity of muscles and joints is controlled contraction, paralysis, card such as dry, puckery.Seek void and the exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and table is not held back the person, and assistant can be shown again admittedly with rheum officinale and so on.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
The radix paeoniae rubrathe: hardship, be slightly cold, return Liver Channel.Clearing heat and cooling blood, blood stasis removing analgesic.Be used for febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, through closing dysmenorrhoea, abdominal mass stomachache, injury from falling down, the carbuncle sore that swells." herbal classic ": main perverse trend stomachache, broken hard long-pending except blood-arthralgia, fever and chills hernia lump in the abdomen, pain relieving, diuresis, beneficial gas." property of medicine opinion ": control the lung perverse trend, Fu Zhong Xu pain, vim and vigour are gathered, and the logical internal organs of declaring are gathered around gas, control evil pain sepsis, disease bone heat when main, strong the five internal organs, kidney tonifying gas, it is hard bloated to control the trusted subordinate, and married woman's blood closes obstructed, and the hemostasis that disappears can lose purulence." not Lu ": clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder intestine and small intestine, subduing inflammation, the time row fever and chills, middle evil stomachache, pain in the back.
Charred RADIX SANGUISORBAE: bitter, acid, liver, stomach, large intestine channel are returned in cold.Have cooling blood and hemostasis, the effect of sore is held back in purging intense heat.The sour and astringent convergence of garden burnet, heat-clearing cool in nature, the bitter sedimentation, the through part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is controlled the card of blood-heat bleeding, and specially clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood-head is used for having blood in stool, hematuria, all cards of uterine bleeding.Bitter cool purging intense heat and detonicating, so sour and astringent convergence myogenic is treatment carbuncle sore tumefacting virus, the particularly good medicine of scald.
Myrobalan: bitter; Acid; Puckery; Property is put down.Convergence, anti-diarrhea effect.It is more that the myrobalan contains tannin, so convergence, anti-diarrhea effect are arranged.The resisting pathogenic microbes effect: myrobalan's water decoction (100%) all has inhibitory action to various shigella dysenteriaes, effect to Pseudomonas aeruginosa, corynebacterium diphtheriae is stronger, and staphylococcus aureus, Escherichia coli, pneumococcus, hemolytic streptococcus, proteus, bacillus typhi murium are also had inhibitory action (flat band method); Its valid density to staphylococcus aureus, the sense of green pus bar, shigella dysenteriae is respectively 1:128,1:64,1:32(test tube method).In addition, the myrobalan also has good antibacterial action external to typhoid bacillus.
Chinese cassia tree: suffering, temperature cures mainly: be used for that impotence, palace are cold, trusted subordinate's crymodynia, the cold of insufficiency type are vomited and diarrhoea, through close, dysmenorrhoea, warming meridians and promoting circulation of qi.Function cures mainly: it is supporing yang to mend fire, let the fire back to its origin, eliminating cold to stop pain, activating blood to promote menstruation.Warming spleen and stomach, removing internal cold, promoting blood circulation.Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion collapse, stomachache is had loose bowels, the cold hernia globefish that runs quickly, waist knee crymodynia, through closing abdominal mass, cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower.
Akebi: bitter, be slightly cold.Go into the heart channel of Hang-Shaoyin, small intestinl channel, urinary bladder channel.Have clearing away the heart-fire, diuresis, the effect of the lactogenesis of stimulating the menstrual flow.Be used for irritable feverish sensation in chestly, larynx numbness pharyngalgia urinate redly, and five drench, oedema, and whole body contraction pain is lacked through closing breast.Heat is drenched puckery pain, oedema.This product energy inducing diuresis for removing edema, following dampness removing heat makes damp and hot heresy descending from the urine discharge.The treatment bladder damp-heat, scanty drak urine is drenched the puckery pain of drop, adapteds such as normal and plantain seed, talcum; Be used for oedema, then be equipped with umbellate pore furgus, the root bark of white mulberry is equal to usefulness.Aphthae, vexed urine is red.The fire of this product energy supernatant the heart channel of Hang-Shaoyin, the heat of letting out small intestine down.Often control flaring up of heart fire, aphthae, or disease such as intestines and the vexed urine that causes is red under the heart-fire moving downward, adapteds such as many and radix rehmanniae recen, Radix Glycyrrhizae, the leaf of bamboo.Few through closing breast.These product lactogenesis of stimulating the menstrual flow.With controlling blood stasis through closing, join safflower, peach kernel, the red sage root and be equal to usefulness; If deficient or obstructed with controlling milk, can be equal to usefulness with the seed of cowherb, pangolin; These product can also sharp blood vessels, get round by bribery, and join ramulus mori, coix seed is equal to usefulness, treats damp and hot numbness pain.
Radix Isatidis: the resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has in various degree inhibitory action to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphosum Bacterium, dysentery (will is congratulated, Fu Shi) bacillus, bacillus enteritidis etc.; The acetone leachate also has similar effect, and to hemolytic streptococcus effective (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and garlic, honeysuckle.Influenza virus PR8 strain and Jing Ke 68-1 strain there is obvious inhibitory action.In vitro Radix Isatidis is killed leptospiral effect.To cardiovascular effect: these product can make the exsomatize rabbit ear and rat lower limb perfusion flow increase, and improve the microcirculation of rabbit mesenterium, reduce the blood pressure of anesthesia rabbit, reduce capillary permeability, and the mouse cardiac muscle oxygen demand is descended.Suppress platelet aggregation effect Radix Isatidis the rabbit platelet aggregation that ADP induces is had remarkable inhibitory action.Get the rabbit platelet aggregation that uridine, hypoxanthine, pyrimidine, salicylic acid etc. induce ATP and also all show certain inhibition activity from Radix Isatidis, its inhibiting rate is respectively 18.2%, 24.2%, 10.8% and 20% when 0.21mg/kg concentration.Detoxication: dog with clothes (each 2.0g/kg), can be separated the black false hellebore poison with Radix Isatidis, coptis powder and black false hellebore, reduces the death rate; If it is use it again behind the veratrum poisoning, then invalid; Single with Radix Isatidis powder or coptis powder respectively, effect is also bad." book on Chinese herbal medicine is stated ": hardship, cold, nontoxic." book on Chinese herbal medicine is just read ": go into liver, stomach blood system." China's book on Chinese herbal medicine ": return liver; The stomach warp.Have heat-clearing, detoxifcation, cool blood, relieve sore throat effect.The treatment febrile virulent maculae; High heat headache; Major part pestilence; Tongue is dark reddish purple dark, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle is swollen; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma is told nosebleed, and pharynx is swollen, pinkeye, sore rash; Can prevent and treat Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis.
Rhizoma cyperi: hot little hardship is sweet, and is flat, goes into liver, tri-jiao channel.The distending pain in hypochondrium; Spargosis is educated; Hernia pain; Irregular menstruation; The full pain of gastral cavity abdomen ruffian; The belch acid regurgitation, the evil of vomitting; Dysmenorrhea; Under the uterine bleeding band; Fetal irritability.
Wrinkled giant hyssop: its gas fragrance, the benefaction stomach Qi in transferring with this, is controlled the vomiting cholera, with this fast gas, except dirty jailbird vexed.Wrinkled giant hyssop can and be closed the five internal organs, if incoordination between the spleen and the stomach, the rib stomach of using and advance diet has the merit of the appetizing of being amusing.Hot energy tonneau nine orifices if haze miasma epidemic disease is used it, does not make in the outer heresy and invades, and the power of presiding over healthy tendency is arranged.All all gas medicines, solely this body is gently warm in nature, can defend gas greatly, specially supports the lung stomach.But leaf belongs to sun, is the thing of generation, and its property is sharp and fragrant looses, and should not obey more.Have Antitussive and Expectorant Effect, anti-inflammatory, antibacterial action.Low dose of geraniol can suppress the spontaneous activity of rat.The oral geraniol of rat can suppress gastrointestinal motility, and in a small amount oral have a slight diuresis." book on Chinese herbal medicine justice ": tsaoko, Xin Wen is dry strong, is apt to eliminating cold-damp and warm dry Middle Palace, so be taste cold-dampness main ingredient.By haze miasma mist wet heresy of exposing private part all, hinder the gas of clear sun most, use warm dry fragrance so ward off miasma more, Yi Shengyin wet suddenly turbid accumulate haunt and plague.Tsaoko control malignant malaria, meaning also still is.Right every malaria, how wet phlegm is hoodwinked to suffering from, so fevers and chills alternate is lingering, controls should open to let out and is elder generation.Tsaoko is kind washs wet phlegm, and the spleen sun that shakes is more assisted it with the wind-weed, considers its component, and the profit and loss at any time, preventing and curing malaria quite have wonderful justice, admittedly needn't aim at the legislation of haze miasma.The real heresy of the stupid what is called of stone Sheng person not only is when at the taboo ear.
Dried human placenta: sweet salty, warm.The effect of have tonifying Qi, nourish blood, benefit is smart.Cure mainly: disease such as deficient, thin thin, hemoptysis asthma, the hot hectic fever due to yin of labor, seminal emission.
Radix Glycyrrhizae: property is flat, and it is sweet to distinguish the flavor of, and returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Be used for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolysis be so that pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Radish seed: property is flat, and flavor is hot, sweet, returns lung, spleen, stomach warp, having to help digestion except expanding, and the effect of lowering the adverse-rising QI to resolve phlegm cures mainly retention of food and drink, abdominal distention, constipation, the stagnant dysentery, phlegm of rushing down is stopped up card such as breath with cough.
Hawthorn: flavor acid, sweet, slightly warm in nature is returned spleen, stomach, Liver Channel, is used for food digesting stomach fortifying, and the promoting the circulation of qi stasis of blood of loosing is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, hawthorn is the staple for the treatment of indigestion, hawthorn can increase the secretion of peptic digest enzyme, promotes to digest; Shigella dysenteriae, Escherichia coli, Pseudomonas aeruginosa, staphylococcus aureus etc. had the obvious suppression effect.
The present invention also provides the preparation method of above-mentioned Chinese traditional medicine composition composition powders, and it comprises:
The first step, each component in the described Chinese medicine composition is mixed in proportion, and the input pulverizer is pulverized or directly chopping, and packing into decocts in the container, add suitable quantity of water and make its submergence medicinal material, soak after 10-25 minute, be heated to boiling after 40-70 minute, separate fried liquid, the dregs of a decoction add water again and decoct 2-3 time, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again;
Second step, treat filtrate cooling after, adding with respect to concentrating back liquid weight 1-2 determining alcohol doubly is 80-90% ethanol, fully mix, placement is spent the night, and makes its precipitation, obtain filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing lotion and merges with filtrate, after ethanol was regained in decompression, dislocation was put cold place, leaves standstill 0.5-1 hour, make precipitation fully, filter, the filtrate low-temperature evaporation obtains paste;
The 3rd step: it is dry that paste is put into spray dryer, guarantees EAT at 180 ℃-200 ℃, and 70 ℃-90 ℃ of leaving air temps are ground into 300 orders-400 order subsequently, obtain Powdered Chinese medicine composition.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
Get coptis 32g, the Chinese bulbul 27 g, frankincense 20 g, cape jasmine 20 g, the wind-weed 15 g, root of Chinese trichosanthes 18 g, Radix Angelicae Sinensis 26 g, the radix paeoniae rubrathe 23 g, charred RADIX SANGUISORBAE 19 g, myrobalan 17 g, Chinese cassia tree 21 g, akebi 20 g, Radix Isatidis 25 g, rhizoma cyperi 14 g, wrinkled giant hyssop 28 g, dried human placenta 15 g, Radix Glycyrrhizae 27 g, radish seed 12 g and hawthorn 27 g; After mixing, pulverize, add the water of 1200g in the mixture after pulverize, decocted 2.5 hours, filter, the water that adds 500g in the filter residue decocted 1.5 hours again, filtered, and with twice filtrate mixing, was evaporated to the decoction that crude drug concentration is 3g/ml.
Get the ICR mouse, body weight restrains at 25-30, by the body weight random packet, and 10 every group, male and female half and half, the oral administration solution administration, dosage only is 6.0ml/.Observed 20 days continuously after the administration, all mouse are strong as a result deposits, and its activity, diet, hair, excreta are no abnormal, do not see toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, and not seeing has irritative response and other bad reaction.
Toxicity test proves, the not toxic effect of this medicine and bad reaction, and clinical practice is safe and reliable.
Embodiment 2 Chinese medicine composition 1 of the present invention and preparation methods
Get coptis 35g, the Chinese bulbul 30 g, frankincense 15 g, cape jasmine 15 g, the wind-weed 12 g, root of Chinese trichosanthes 14 g, Radix Angelicae Sinensis 30 g, the radix paeoniae rubrathe 21 g, charred RADIX SANGUISORBAE 16 g, myrobalan 13 g, Chinese cassia tree 16 g, akebi 17 g, Radix Isatidis 30 g, rhizoma cyperi 18 g, wrinkled giant hyssop 32 g, dried human placenta 12 g, Radix Glycyrrhizae 20 g, radish seed 13 g and hawthorn 20 g; The input pulverizer is pulverized or directly chopping, pack into and decoct in the container, add suitable quantity of water and make its submergence medicinal material, soak after 25 minutes, be heated to boiling after 65 minutes, separate fried liquid, the dregs of a decoction add water again and decoct 3 times, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again; After treating the filtrate cooling, adding with respect to the determining alcohol that concentrates 2 times of back liquid weights is 90% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that 55% ethanol is cleaned, and collects washing lotion and merges with filtrate, after ethanol is regained in decompression, dislocation is put cold place, left standstill 40 minutes, and made precipitation fully, filter, the filtrate low-temperature evaporation obtains paste; It is dry that paste is put into spray dryer, guarantees EAT at 190 ℃, and 80 ℃ of leaving air temps are ground into 400 orders subsequently, obtains powder Chinese traditional medicine composition composition powders.
Embodiment 3 Chinese medicine composition 2 of the present invention and preparation methods
Get coptis 27g, Chinese bulbul 26g, frankincense 19 g, cape jasmine 15 g, the wind-weed 20 g, root of Chinese trichosanthes 22 g, Radix Angelicae Sinensis 32 g, the radix paeoniae rubrathe 24 g, charred RADIX SANGUISORBAE 20 g, myrobalan 21 g, Chinese cassia tree 12 g, akebi 23 g, Radix Isatidis 18 g, rhizoma cyperi 12g, wrinkled giant hyssop 22 g, dried human placenta 11g, Radix Glycyrrhizae 32 g, radish seed 10 g and hawthorn 32 g; The input pulverizer is pulverized or directly chopping, pack into and decoct in the container, add suitable quantity of water and make its submergence medicinal material, soak after 20 minutes, be heated to boiling after 60 minutes, separate fried liquid, the dregs of a decoction add water again and decoct 2 times, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again; After treating the filtrate cooling, adding with respect to the determining alcohol that concentrates 1.5 times of back liquid weights is 85% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that 50% ethanol is cleaned, and collects washing lotion and merges with filtrate, after ethanol is regained in decompression, dislocation is put cold place, left standstill 1 hour, and made precipitation fully, filter, the filtrate low-temperature evaporation obtains paste; It is dry that paste is put into spray dryer, guarantees EAT at 185 ℃, and 85 ℃ of leaving air temps are ground into 350 orders subsequently, obtains powder Chinese traditional medicine composition composition powders.
Embodiment 4 Chinese medicine composition 3 of the present invention and preparation methods
Get coptis 32g, the Chinese bulbul 27 g, frankincense 20 g, cape jasmine 20 g, the wind-weed 15 g, root of Chinese trichosanthes 18 g, Radix Angelicae Sinensis 26 g, the radix paeoniae rubrathe 23 g, charred RADIX SANGUISORBAE 19 g, myrobalan 17 g, Chinese cassia tree 21 g, akebi 20 g, Radix Isatidis 25 g, rhizoma cyperi 14 g, wrinkled giant hyssop 28 g, dried human placenta 15 g, Radix Glycyrrhizae 27 g, radish seed 12 g and hawthorn 27 g; The input pulverizer is pulverized or directly chopping, pack into and decoct in the container, add suitable quantity of water and make its submergence medicinal material, soak after 15 minutes, be heated to boiling after 50 minutes, separate fried liquid, the dregs of a decoction add water again and decoct 3 times, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again; After treating the filtrate cooling, adding with respect to the determining alcohol that concentrates 1 times of back liquid weight is 80% ethanol, fully mixes, placement is spent the night, and makes its precipitation, obtains filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that 60% ethanol is cleaned, and collects washing lotion and merges with filtrate, after ethanol is regained in decompression, dislocation is put cold place, left standstill 0.5 hour, and made precipitation fully, filter, the filtrate low-temperature evaporation obtains paste; It is dry that paste is put into spray dryer, guarantees EAT at 195 ℃, and 75 ℃ of leaving air temps are ground into 300 orders subsequently, obtains powder Chinese traditional medicine composition composition powders.
Embodiment 5 feed 1 of the present invention and preparation methods
A kind of feed only comprises feed vector and Chinese medicine composition as additive, and its ratio of weight and number is 100 weight portions: 5 weight portions, wherein, each component and weight are corn 5000g, dregs of beans 3000g composite bacillus 35g and yucconin 5g in the feed vector.Wherein, it is standby that the Chinese medicine composition additive is got the Chinese traditional medicine composition composition powders 1 of embodiment 2 preparation.
The preparation method of feed is as follows: get 5000g corn and 3000g dregs of beans, be ground into 180 purpose powder after mixing, 120 ℃ temperature bottom fermentations 5 days, the oven dry under 65 ℃ of temperature of fermentation back was ground into powder; Take by weighing composite bacillus 35g, yucconin 5g and Chinese medicine composition 402g, and with after the above-mentioned powder that obtains fully mixes, drop into granulator and granulate, pelleting temperature is 75 ℃, obtains pellet; The above-mentioned pellet that obtains is spread on the ebullated bed of boiling drier, heat drying 15 minutes, the import wind-warm syndrome of heating degree is 130 ℃, obtains the dried granules feed.
Embodiment 6 feed 2 of the present invention and preparation methods
A kind of feed only comprises feed vector and Chinese medicine composition as additive, and its ratio of weight and number is 100 weight portions: 4 weight portions, wherein, each component and weight are corn 5500g, dregs of beans 2500g composite bacillus 40g and yucconin 7g in the feed vector.Wherein, it is standby that the Chinese medicine composition additive is got the Chinese traditional medicine composition composition powders 2 of embodiment 3 preparation.
The preparation method of feed is as follows: gets 5500g corn and 2500g dregs of beans, is ground into 180 purpose powder after mixing, and 130 ℃ temperature bottom fermentations 6 days, the oven dry and be ground into powder under 70 ℃ of temperature of fermentation back; Take by weighing composite bacillus 40g, yucconin 7g and Chinese medicine composition 322g according to ratio of weight and number, and with after the above-mentioned powder that obtains fully mixes, drop into granulator and granulate, pelleting temperature is 80 ℃, obtains pellet; The above-mentioned pellet that obtains is spread on the ebullated bed of boiling drier, heat drying 12 minutes, the import wind-warm syndrome of heating degree is 125 ℃, obtains the dried granules feed.
Embodiment 7 clinical testings
(1) material is prepared
Experimental chicken and place are chosen:
Select Xixia City, Yantai, Shandong Province broiler chicken to culture factory and be the experiment base, 300 healthy chicks of picked at random 5 ages in days are as prevention contrast test object; 300 conduct treatments of the broiler chicken of picked at random 35 age in days health contrast test object.
(2) bacterial strain extracts and cultivates:
30 chickens that die of illness to 6 broiler chicken fields, area, Yantai, Shandong are cutd open inspection, the die of illness internal organs such as the heart, kidney of chicken of aseptic collection are smeared and are inoculated in blood agar plate, cultivate 15-20h for 37 ℃, the pure culture of picking colonies typical, carry out the biochemical fermentation test according to a conventional method, and do reference with reference culture, it is carried out biochemical identification.Randomly draw the bacterium colony of agar pure culture, be inoculated in the nutrient broth, 37 ℃ cultivate 24 hours standby.
(3) prevention contrast experiment:
300 5 age in days broiler chicken of random choose are divided into 3 groups (control group 1, control group 2 and embodiment groups) at random, wherein, control group 1 and control group 2 use traditional broiler fodder feeding dorking respectively, the embodiment group is used feed 1 feeding dorking among the embodiment 5, feed after 7 days, control group 1 and embodiment group are carried out the artificial challenge with 5 times of dilutions of standby culture, lumbar injection 0.2mL/ only, observed and recorded is respectively organized the incidence of disease and the death rate of broiler chicken, and the result is as shown in table 1.
The table 1 preventive effect table of comparisons
From the data of table 1 as can be known: the feed that the present invention contains Chinese medicine composition has tangible preventive effect to chicken colibacillosis.
(4) treatment contrast test:
Broiler chicken with 300 35 ages in days of cultured solution of broth lumbar injection is divided into 3 groups (treatment by Chinese herbs group, western medicine group, blank groups) at random, occur treating with different medicines after the clinical symptoms, wherein, the treatment by Chinese herbs group is selected the Chinese medicine composition 3 of embodiment 4 for use, dose be every every day 0.5g; The western medicine group selects for use chloramphenicol 10mg/mL, orfloxacin 20mg/mL to carry out the neck injection; The blank group is not fed any medicine.Observed and recorded is respectively organized the incidence of disease, cure rate and the death rate of broiler chicken, and the result is as shown in table 2.
The table 2 result for the treatment of table of comparisons
From the data of table 2 as can be known: Chinese medicine composition of the present invention to chicken colibacillosis and result for the treatment of obviously be better than the western medicine group, reduce the death rate, improve cure rate.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. the feed that is used for the treatment of chicken colibacillosis, it is characterized in that, comprise feed vector and Chinese medicine composition, each component is in the described Chinese medicine composition: the coptis, the Chinese bulbul, frankincense, cape jasmine, the wind-weed, root of Chinese trichosanthes, Radix Angelicae Sinensis, the radix paeoniae rubrathe, charred RADIX SANGUISORBAE, myrobalan, Chinese cassia tree, akebi, Radix Isatidis, rhizoma cyperi, wrinkled giant hyssop, dried human placenta, Radix Glycyrrhizae, radish seed and hawthorn;
The ratio of weight and number of various components is in the described Chinese medicine composition: coptis 20-45 part, Chinese bulbul 25-35 part, frankincense 15-25 part, cape jasmine 14-27 part, wind-weed 10-20 part, root of Chinese trichosanthes 10-25 part, Radix Angelicae Sinensis 20-35 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 15-25 part, myrobalan 10-25 part, Chinese cassia tree 10-35 part, akebi 15-25 part, Radix Isatidis 10-35 part, rhizoma cyperi 10-20 part, wrinkled giant hyssop 20-35 part, dried human placenta 10-20 part, Radix Glycyrrhizae 20-35 part, radish seed 10-15 part and hawthorn 15-35 part;
Described feed vector comprises corn, dregs of beans, composite bacillus and yucconin; The ratio of weight and number of each component is in the described feed vector: corn 40-65 part, dregs of beans 20-45 part, composite bacillus 0.1-0.5 part and yucconin 0.01-0.08 part;
The ratio of weight and number of described feed vector and described Chinese medicine composition is 100 weight portions: the 1-5 weight portion.
2. the feed that is used for the treatment of chicken colibacillosis according to claim 1, it is characterized in that the ratio of weight and number of various components is in the described Chinese medicine composition: coptis 25-40 part, Chinese bulbul 25-30 part, frankincense 18-22 part, cape jasmine 18-24 part, wind-weed 13-18 part, root of Chinese trichosanthes 17-20 part, Radix Angelicae Sinensis 25-30 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 18-21 part, myrobalan 15-20 part, Chinese cassia tree 15-30 part, akebi 18-22 part, Radix Isatidis 17-30 part, rhizoma cyperi 12-18 part, wrinkled giant hyssop 26-30 part, dried human placenta 12-17 part, Radix Glycyrrhizae 25-30 part, radish seed 10-14 part and hawthorn 25-30 part.
3. the feed that is used for the treatment of chicken colibacillosis according to claim 1 and 2 is characterized in that, described composite bacillus is multiple in bacillus subtilis, bacillus licheniformis and the bacillus cereus.
4. Chinese medicine composition that is used for the treatment of chicken colibacillosis, it is characterized in that described Chinese medicine composition is made up of the bulk drug of following ratio of weight and number: coptis 25-40 part, Chinese bulbul 25-30 part, frankincense 18-22 part, cape jasmine 18-24 part, wind-weed 13-18 part, root of Chinese trichosanthes 17-20 part, Radix Angelicae Sinensis 25-30 part, radix paeoniae rubrathe 20-25 part, charred RADIX SANGUISORBAE 18-21 part, myrobalan 15-20 part, Chinese cassia tree 15-30 part, akebi 18-22 part, Radix Isatidis 17-30 part, rhizoma cyperi 12-18 part, wrinkled giant hyssop 26-30 part, dried human placenta 12-17 part, Radix Glycyrrhizae 25-30 part, radish seed 10-14 part and hawthorn 25-30 part.
5. the Chinese medicine composition that is used for the treatment of chicken colibacillosis according to claim 4 is characterized in that, the preparation method of described Chinese medicine composition comprises:
The first step, each bulk drug in the described Chinese medicine composition is mixed in proportion, and the input pulverizer is pulverized or directly chopping, and packing into decocts in the container, add suitable quantity of water and make its submergence medicinal material, soak after 10-25 minute, be heated to boiling after 40-70 minute, separate fried liquid, the dregs of a decoction add water again and decoct 2-3 time, the fried liquid that separated and collected is each through after filtering, is got filtrate and is abandoned filter residue again;
Second step, treat filtrate cooling after, adding with respect to concentrating back liquid weight 1-2 determining alcohol doubly is 80-90% ethanol, fully mix, placement is spent the night, and makes its precipitation, obtain filtrate after getting its supernatant liquid filtering next day, the sediment determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing lotion and merges with filtrate, after ethanol was regained in decompression, dislocation was put cold place, leaves standstill 0.5-1 hour, make precipitation fully, filter, the filtrate low-temperature evaporation obtains paste;
The 3rd step: it is dry that paste is put into spray dryer, guarantees EAT at 180 ℃-200 ℃, and 70 ℃-90 ℃ of leaving air temps are ground into 300 orders-400 order subsequently, obtain Powdered Chinese medicine composition.
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| CN104800676A (en) * | 2014-01-26 | 2015-07-29 | 天津嘉创生物科技有限公司 | Traditional Chinese medicinal composition for treating chicken colibacillosis, and preparation method thereof |
| CN103947869A (en) * | 2014-04-08 | 2014-07-30 | 安徽壮大饲料有限公司 | Premix for preventing laying hen from getting colibacillosis at laying period |
| CN105998312A (en) * | 2016-05-10 | 2016-10-12 | 烟台东和生态农牧科研所 | Traditional Chinese medicine composition for treating chicken salmonellosis and chicken feed |
| CN105832983A (en) * | 2016-05-17 | 2016-08-10 | 李莉 | Chinese herbal medicine preparation for preventing and treating mother graylag uterus seasonal febrile diseases |
| CN106491933A (en) * | 2016-10-25 | 2017-03-15 | 杨明军 | A kind of Chinese medicine formula of prevention chicken colibacillosis |
| CN106615942A (en) * | 2016-12-21 | 2017-05-10 | 广西浩昌敏再生资源利用有限公司 | Fodder for preventing and treating chicken colibacillosis and preparation method thereof |
| CN106986511A (en) * | 2017-06-13 | 2017-07-28 | 吕欣荣 | A kind of kitchen sewage handling process |
| CN107279583A (en) * | 2017-08-08 | 2017-10-24 | 西安格润牧业股份有限公司 | A kind of chicken feed for preventing and treating Escherichia coli and preparation method thereof |
| CN107981093A (en) * | 2017-12-15 | 2018-05-04 | 阜阳市玉琪农业科技有限公司 | A kind of feed for preventing E. coli isolated from ducks and preparation method thereof |
| CN115887535B (en) * | 2022-09-26 | 2023-09-08 | 吉林农业大学 | Compound Chinese medicinal residue fermentation liquor for preventing and treating colibacillosis of poultry and preparation method thereof |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101238858A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for preventing and controlling yellow and white scour of piglets |
| CN101683116A (en) * | 2008-09-23 | 2010-03-31 | 张松灿 | Pure traditional Chinese medicine feed additive |
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2012
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