The specific embodiment
China's Chinese herbal medicine resource vast in territory is very abundant, aspect the development Chinese herb feed additive great potential is being arranged, a large amount of production practices and scientific research have confirmed that also Chinese herbal medicine has many nutritional labelings and bioactivator, as alkaloid, polysaccharide, volatile oil, organic acid etc., have the double action of the property of medicine and trophism concurrently, both preventable disease can improve production performance again; Direct bactericidal not only, and can regulate the immunity function of body, have non-special antibacterial action.Therefore abandon the chemical classes additive, use the relieved feed addictive of safety, making food reach the delicious effect of safety is our consistent pursuit; Advantage that the more important thing is the Chinese herb feed additive uniqueness is to have pure natural property, from nature animal, plant and mineral matter, and its natural structure and activity have been kept, the long-term use and drug residue free, the no resistance to the action of a drug and have no side effect, it is good green medicated premix, also catered to consumers in general and culturist to the pursuit of green non-pollution no drug residue product, in breeding feed, seemed more meaningful so make feed addictive with Chinese herbal medicine.
Chinese herb feed additive has non-special antibacterial action; fundamentally protect and coordinate the holistic health of animal; can prevent disease, enhancing body's immunological function is driven away harmful parasite in the body; beneficial microbe group in the control agent; give full play to and improve the potential ability that body itself has, Chinese herb feed additive can improve digestibility, the utilization rate of nutriment, strengthens the metabolism of livestock and poultry; stimulate circulation, improve the speed of growth.Chinese herbal medicine is of a great variety, and aboundresources can be gathered materials on the spot, and uses simple and easy, convenience, is easy to large-scale promotion and uses.The pure natural property Chinese herbal medicine mostly is medical practice confirmation natural plants or the product useful and harmless to human and livestock health through several thousand, can play disease preventing and treating, the effect that promotion is grown, its unique advantage is to use drug residue free, the no resistance to the action of a drug for a long time and have no side effect, and is good green medicated premix.Multiple functional Chinese herbal medicine is complicated organism, multicomponent own and in addition reasonable combination formed the physiological function of the multipotency performance across-the-board regulation body of the unified uniqueness of Total tune, have the double action of nutriment and medicine concurrently, but not only disease preventing and treating but also can improve production performance, has the nospecific immunity antibacterial action, a certain single chemical composition is difficult to mention in the same breath with Chinese herbal medicine, is that chemical synthetic drug is incomparable.Chinese herbal feed additive is theoretical and the animal different needs is formulated according to Chinese veterinarian by the Chinese herbal medicine of various flavor function, and is various owing to of a great variety, complex structure, composition, determined the Chinese herbal medicine of different compositions to have different effects.
Raise together with in the breed of fish pattern, obtain best productivity effect and just must further investigate the nutritional need of various fresh-water fishes, prepare feed according to nutritional requirement, in addition, the additive that adds safety nuisance free in the feed is particularly important.Chinese medicine additive can promote digestion and the absorption of fresh-water fishes, promotes growth performance, improves the speed of growth, improves food conversion ratio.
Embodiment 1
At as under the prerequisite that improves the grass carp cultured output, improve the output of other breed variety, increase the problem of economic benefit, the embodiment of the invention provides a kind of fish meal of raising together with, and the ratio of weight and number of raw material is in its feed: 28 parts of dregs of beans, 31 parts of rape cakes, 13 parts of rice bran meals, 2 parts of salt, 0.3 part of liquid vitamin C, 1.0 parts of betaines, 2 parts of rare-earth forage additives, 1.2 parts of Chinese medicine additives.
Wherein, the ratio of weight and number of bulk drug is in the Chinese medicine additive: 14 parts of golden cypresses, 12 parts of the roots of large-flowered skullcap, 11 parts of rheum officinales, 9 parts of wilsoniis, 10 parts of spirit grass, 15 parts of Lysimachia sikokianas, 14 parts of rhizoma nardostachyos, 15 parts of the roots of Dahurain angelica, 15 parts of Radix Isatidis, 15 parts of Herba Andrographitis, 10 parts of the tubers of stemona, 12 parts of cordate houttuynias, 14 parts of folium isatidis, 4 parts of quassias, 9 parts of glossy ganodermas, 15 parts in garlic, 11 parts of rabdosia lophanthides, 12 parts of chrysanthemums, 12 parts of honeysuckles, 8 parts in Chinese gall.
The preparation method of Chinese medicine additive comprises: take by weighing described bulk drug proportioning according to ratio of weight and number and mix, the acid and alkali-resistance infusion kettle is put in chopping, at room temperature, flooded 18 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, cool off the back and grind to form fine-powdered, obtain Chinese medicine additive.
The present invention also provides a kind of preparation method who raises together with fish meal, and its preparation process comprises: pulverising step: take by weighing all raw materials by weight percentage, drop into pulverizer and pulverize, grinding particle size is 40 orders; Blend step: abundant mixing, incorporation time is 120s; Granulation step: drop into granulator and granulate, pelleting temperature is 90 ℃, makes its gelatinization degree reach 45-50%.
By the feed that said method obtains, its nutritive value is: crude protein 30.36, crude fat 5.50, crude fibre 8.51, coarse ash 9.05, calcium 0.66, total phosphorus 1.38, salt 0.40, total lysine 1.60, methionine 0.49, total methionine 1.04.
Embodiment 2
The embodiment of the invention provides a kind of fish meal of raising together with, and the ratio of weight and number of raw material is in its feed: 23 parts of dregs of beans, 38 parts of rape cakes, 15 parts of rice bran meals, 2 parts of salt, 0.4 part of liquid vitamin C, 1.2 parts of betaines, 1.5 parts of Chinese medicine additives.
Wherein, the ratio of weight and number of bulk drug is in the Chinese medicine additive: 16 parts of golden cypresses, 10 parts of the roots of large-flowered skullcap, 9 parts of rheum officinales, 7 parts of wilsoniis, 7 parts of spirit grass, 13 parts of Lysimachia sikokianas, 16 parts of rhizoma nardostachyos, 12 parts of the roots of Dahurain angelica, 12 parts of Radix Isatidis, 13 parts of Herba Andrographitis, 12 parts of the tubers of stemona, 12 parts of cordate houttuynias, 16 parts of folium isatidis, 5 parts of quassias, 12 parts of glossy ganodermas, 12 parts in garlic, 12 parts of rabdosia lophanthides, 14 parts of chrysanthemums, 10 parts of honeysuckles, 10 parts in Chinese gall.
The preparation method of Chinese medicine additive comprises: take by weighing described bulk drug proportioning according to ratio of weight and number and mix, the acid and alkali-resistance infusion kettle is put in chopping, at room temperature, flooded 18 days with the above ethanol of 90 degree, liquid and the dregs of a decoction that dipping is good carry out squeeze and filter, get filtrate after the separation; Described filtrate heating is concentrated into pasty state, puts into drying in oven, cool off the back and grind to form fine-powdered, obtain Chinese medicine additive.
The present invention also provides a kind of preparation method who raises together with fish meal, and its preparation process comprises: pulverising step: take by weighing all raw materials by weight percentage, drop into pulverizer and pulverize, grinding particle size is 40 orders; Blend step: abundant mixing, incorporation time is 120s; Granulation step: drop into granulator and granulate, pelleting temperature is 95 ℃, makes its gelatinization degree reach 45-50%.
By the feed that said method obtains, its nutritive value is: crude protein 30.36, crude fat 5.50, crude fibre 8.51, coarse ash 9.05, calcium 0.66, total phosphorus 1.38, salt 0.40, total lysine 1.60, methionine 0.49, total methionine 1.04.
Each component pharmacology is as follows in the Chinese medicine additive:
Golden cypress: bitter, cold in nature, return kidney, bladder, large intestine channel, be used for damp-heat dysentery, jaundice, under the band, heat is drenched, beriberi, impotence is warded off, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema itch.Stir-baked CORTEX PHELLODENDRI with salt solution is nourishing Yin and falling fire.For fire excess from yin deficiency, the night sweat hectic fever due to yin.
The root of large-flowered skullcap: heat-clearing and damp-drying drug is arranged, and cool blood is antiabortive, detoxicating functions.Cure mainly diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical practice of the root of large-flowered skullcap is antibiotic not worse than the coptis, and does not develop immunity to drugs.We are by the strong characteristics of broad-spectrum antibacterial action, and it is special severe to be used in the fungal culture microbial contamination, and are fine with root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so except evil: so bitter eliminating dampness; So cold sensation of the genitalia wins heat, so main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines be out-of-the-way, let out dysentery, the disease of all damp and hot victory is also analysed it, then all diseases are from recover.Bitter cold can be except damp and hot, thus small intestine profit and water from pursuing, the source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood chamber makes us obstructed through closing, damp and hot solution, then Ying Qi is clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head is then stayed knot, and is that the swollen stain of carbuncle is mashed also: fiery ulcer person, the internal heat blood trouble also, cool blood heat extraction, then self-healing also.
Rheum officinale: bitter, cold in nature, return stomach, spleen, large intestine, liver, pericardium channel, have the purgating heat and bowels effect, be used for that the real heat of stomach and intestine is stagnant, constipation, belly turgor, pain with tenderness, even hyperpyrexia, coma and delirium, as dachengqi decoction; Or the cold accumulation and constipation of spleen YANG deficiency.The removing toxicity for eliminating carbuncles effect is used for pathopyretic ulcer, sudden and violent cute conjunctivitis pain, aphthae, gingivitis.The removing damp-heat effect is for jaundice, difficult urination, the dry and hard excrement of stagnation of damp-heat; Heat pouring, urolithiasis such as Bazheng San.
Wilsonii: flavor suffering, little hardship, slightly warm in nature.Return spleen, kidney, the heart channel of Hang-Shaoyin.Modern medicine studies have shown that effect characteristics and the genseng of wilsonii is basic identical, has the disorder of the body of adjusting, makes it to be tending towards normal function.Good antifatigue effect is arranged, remarkable than genseng, and can significantly improve hypoxia-bearing capability.Bowl spares, smart, the strong will of benefit, dispel the wind wet, strengthen the bone, functions such as blood circulation and promoting silt, stomach invigorating diuresis.Obey for a long time " make light of one's life by commiting suicide and endure hardships ".Wilsonii contains noticeable composition---eleutheroside, and it can stimulate the mind ﹠ body vigor.Numerous scientific publication things about wilsonii have proved its antifatigue effect, strengthen endurance and ability, increase alertness and learning ability.Numerous usages have all obtained confirmation in human experimentation.Wilsonii is rehabilitation after being ill, bears too much pressure or anxiety, and it is excessive to work, and chronic disease causes weakly crowd and those need reach the very welcome self-medication medicine of philtrum on physiology and psychological performance peak.At present there is the report of considerable quantity to point out that it has the support immune system equally, recovers improper low blood pressure, improve the circulatory system, make disorderly glycolipid metabolism normalization, liver, testis, the anabolic effect of bone density and other vitals.But siberian Ginseng P.E shows irritation cell immunity.Discover that it can stimulate the T-cell to produce, particularly assistant's cell.Therefore wilsonii is used to the panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has had strong inhibitory effects to mouse S180, human leukemia K562 cells in vitro propagation, and siberian Ginseng P.E contains multiple glucoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, increasing leukocyte, raising body to anoxic, radiation, stress, the adaptive capacity of non-specific injuries such as fatigue, poisoning.Tumour there is the obvious suppression effect, also can promotes marrow hemopoietic stem cells to grain-monocyte differentiation leucocyte to be increased simultaneously.
Spirit grass: have another name called Radix Glycyrrhizae; Property is put down, and it is sweet to distinguish the flavor of, and returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Be used for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolysis be so that pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Lysimachia sikokiana: it is sweet to distinguish the flavor of, and property is flat, and is nontoxic.Function cures mainly: cure cold, cough and breathe heavily, rheumatalgia, irregular menstruation." middle traditional Chinese medicines are planted will ": " control weakness." " Sichuan Chinese medicinal herbal ": " it is wet to dispel the wind, and regulates the flow of vital energy, and ends the gas pain, and freckle is put in the restoring consciouness relieving restlessness on the skin." " GUIHAIA register ": " beneficial gas qi-restoratives, expelling wind and activating blood flow.Control weakness, tracheitis, asthma, irregular menstruation, cold cough.”
Rhizoma nardostachyos: it is hot, sweet, warm to distinguish the flavor of.Return spleen, stomach warp.Function with cure mainly: promoting qi circulation and relieving pain, relieving stagnation to activate spleen.External application clearing damp detumescence.Be used for burnt cold obstruction causing qi stagnation, incoordination between the spleen and the stomach, poor appetite, vomiting; Toothache is controlled in external application.Compendium of Material Medica: " rhizoma nardostachyos, it is strongly fragrant that fragrance can be opened spleen, adds in the taste medicine gas of very being amusing less "." book on Chinese herbal medicine converges and says ": " rhizoma nardostachyos, the medicine of the smooth stomach of being amusing also." opening treasured side " main sudden attack of pain in the chest and abdomen, the full therapeutic method to keep the adverse qi flowing downward of loosing is all got the diffusing meaning of Wen Xianghang.Its gas fragrance is gone in the taste medicine, holds up spleen pleasant greatly, the merit of appetite-stimulating indigestion-relieving.”
The root of Dahurain angelica: flavor is hot, and is warm in nature, goes into lung, spleen, stomach warp, having induces sweat loose cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness is ended band, and the effect of detumescence and apocenosis cures mainly headache, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin is dry itches cards such as mange.
Radix Isatidis: the resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has in various degree inhibitory action to hay bacillus, staphylococcus aureus, sarcine, Escherichia coli, typhoid bacillus, paratyphosum Bacterium, dysentery (will is congratulated, Fu Shi) bacillus, bacillus enteritidis etc.; The acetone leachate also has similar effect, and to hemolytic streptococcus effective (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and garlic, honeysuckle. influenza virus PR8 strain and Jing Ke 68-1 strain there are obvious inhibitory action.In vitro Radix Isatidis is killed leptospiral effect.To cardiovascular effect: these product can make the exsomatize rabbit ear and rat lower limb perfusion flow increase, and improve the microcirculation of rabbit mesenterium, reduce the blood pressure of anesthesia rabbit, reduce capillary permeability, and the mouse cardiac muscle oxygen demand is descended.Suppress platelet aggregation effect Radix Isatidis the rabbit platelet aggregation that ADP induces is had remarkable inhibitory action.Get the rabbit platelet aggregation that uridine, hypoxanthine, pyrimidine, salicylic acid etc. induce ATP and also all show certain inhibition activity from Radix Isatidis, its inhibiting rate is respectively 18.2%, 24.2%, 10.8% and 20% when 0.21mg/kg concentration.Detoxication: dog with clothes (each 2.0g/kg), can be separated the black false hellebore poison with Radix Isatidis, coptis powder and black false hellebore, reduces the death rate; If it is use it again behind the veratrum poisoning, then invalid; Single with Radix Isatidis powder or coptis powder respectively, effect is also bad." book on Chinese herbal medicine is stated ": hardship, cold, nontoxic." book on Chinese herbal medicine is just read ": go into liver, stomach blood system." China's book on Chinese herbal medicine ": return liver; The stomach warp.Have heat-clearing, detoxifcation, cool blood, relieve sore throat effect.The treatment febrile virulent maculae; High heat headache; Major part pestilence; Tongue is dark reddish purple dark, scarlet fever; Erysipelas; Mumps; Larynx numbness; Sore is swollen, carbuncle is swollen; Varicella; Measles; Hepatitis; Influenza, epidemic meningitis, encephalitis, pneumonia, coma is told nosebleed, and pharynx is swollen, pinkeye, sore rash; Can prevent and treat Japanese Type-B encephalitis, acute, chronic hepatitis, mumps, osteomyelitis.
Herba Andrographitis: bitter, cold in nature.The thoughts of returning home, lung, large intestine, urinary bladder channel.Effect cures mainly: cold, fever, and abscess of throat, aphthae, pertussis labor is coughed, dysentery, heat is drenched puckery pain, the carbuncle sore that swells, venomous snake bite.Clearing heat and detoxicating, cool blood detumescence.Control acute bacillary dysentery, gastroenteritis, flu, epidemic meningitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, nosebleed epistaxis, oropharynx swells and ache, and sore furuncle carbuncle is swollen, scald, venomous snake bite.
The tuber of stemona: sweet, bitter, tepor.Return lung channel.The moistening lung to lower qi cough-relieving, desinsection.Be used for new chronic cough and cough pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, private parts is disturbed and is itched.The honey tuber of stemona moistens the lung and relieve the cough.Being used for deficiency of Yin labor coughs.Tuber of stemona bactericidal effect is good, and can also prevent and treat cough due to wind-cold evil etc.
Cordate houttuynia: suffering is slightly cold.Return lung channel, be used as medicine, the traditional Chinese medical science thinks that its flavor is hot, cold, energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, stomach strengthening and digestion promoting are treated in the detumescence of row's pain, with controlling lung carbuncle that real heat, heat poison, damp evil, disease heat are trouble, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc., list is used or the compatibility compound, the equal determined curative effect of the use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, the cordate houttuynia master contains volatile oil, and multiple components such as decanoyl acetaldehyde decanoy acetaldehyde have the inhibition antibacterial action to various Xenorhabduses, coccus, influenza virus, Leptospira etc., and can improve the human immunity regulatory function.
Folium isatidis: bitter, cold in nature, the thoughts of returning home, stomach warp, folium isatidis function clearing heat and cooling blood, be the detoxifcation key medicine, be mainly used in the heat poison and send out spot, erysipelas, abscess of throat, aphthae that folium isatidis is used for warm disease and evil and goes into all diseases due to blood system and the hot poison, return the stomach warp, effect is heat-clearing.
Quassia: nature and flavor are cold in nature, bitter.Return lung, large intestine channel.Function cures mainly heat-clearing, clearing damp, detoxifcation.Be used for anemopyretic cold, abscess of throat, diarrhoea diarrhea, eczema, sore furuncle, venomous snake bite.To the influence of blood flow, the canthinone in the quassia is given the quiet notes of rabbit 0.3mg/kg, can increase the blood flow rate of rabbit intestines and stomach, and increment rate respectively is 15%, 10%.And quassia alkali D, 5-hydroxyl-4-methoxyl group canthinone (5-hydroxyl-quassia alkali) F and kumujian B only increase the blood flow rate of rabbit intestines.The Study on Mechanism that quassia is increased blood flow finds that the alkaloid in the quassia has inhibitory action to the cAMP phosphodiesterase.The 1-methoxyl group carbon back-carboline that is separated to from the quassia base portion has inhibitory action to OX-heart cAMP phosphodiesterase, and its IC50 is 3.6 * l0(-5) mol/L.The IC50 of 5-hydroxyl-4-methoxyl group canthinone is 1.4 * l0(-5) mol/L, and the IC50 of 4,5-dimethoxy canthinone is 10.4 * l0(-5).Picrasmin glucoside-the B that is separated to from quassia has inhibitory action in external growth to lymphocytic leukemia P388 cell line, but its action intensity is weaker than 5 FU 5 fluorouracil.In the quassia-carboline is in the external activity that anti-herpes simplex virus is arranged.The parenteral solution that the quassia branches and leaves are made (the 2g crude drug/ml) to small white mouse (0.2-0.5ml/ is only) and dog (8ml/ is only) hypodermic injection; the protective effect that the small white mouse that bungarotoxin is poisoned and dog have highly significant; the small white mouse protective rate is 75.6%, and the dog protective rate is 100%.
Glossy ganoderma: property is sweet, and is flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, indigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has inhibitory action to nervous system, and the circulatory system has step-down and strengthens the effect of cardiac contractile force, and respiratory system is had phlegm-dispelling functions, in addition, protects liver in addition, improves immunologic function, effect such as antibiotic grade.
Garlic: warm in nature, flavor is hot flat; Go into spleen, stomach, lung channel.The detoxifcation desinsection, swelling and pain relieving, antidiarrheal is ended dysentery, controls lung, and expelling parasite also has warm spleen to warm up stomach in addition.Control swollen ulcer drug, white bald tinea sore, dysentery is had loose bowels, the tuberculosis pertussis, the roundworm pinworm, eating accumulation, coldness and pain in the epigastrium, the oedema turgor, promoting the circulation of qi disappears long-pending, the desinsection detoxifcation.Be used for flu, bacillary dysentery, amoebic dysentery, enteritis, eating accumulation, the swollen sore of carbuncle.Strong disinfecting: sulfur-containing compound has strong antibacterial and anti-inflammation functions in the garlic, multiple coccus, bacillus, fungi and virus etc. is all had suppress and killing action, is the strongest a kind of of antibacterial action in the natural plants of finding at present.Anti-curing oncoma and cancer: elements such as the germanium in the garlic and selenium can suppress the growth of tumour cell and cancer cell, and experiment finds that the crowd that the cancer incidence is minimum is exactly the highest crowd of selenium content in the blood.The American National cancerous tissue thinks that in the plant of the anticancer potentiality of tool in the whole world, what rank first is garlic.Toxin-expelling intestine-cleaning, the prevention gastrointestinal disease: garlic can effectively suppress and kill the bacterial viruses such as helicobacter pylori that cause gastrointestinal disease, removes the stomach noxious material, and the stimulating gastrointestinal mucous membrane promotes appetite, accelerates digestion.Reduce blood sugar, the prevention diabetes: garlic can promote secretion of insulin, increases histocyte to the absorption of glucose, improve the human glucose tolerance, reduce blood sugar level in the body rapidly, and can kill the various germs because of the infection-induced diabetes, thereby effectively prevent and treat diabetes.The control cardiovascular and cerebrovascular disease: garlic can prevent the fat deposition in the cardiovascular and cerebrovascular, the metabolism of induced tissue fat inside, significantly increase FA, reduce cholesterol, suppress hematoblastic gathering, reduce PC, increase arteriolar expansion ratio, impel vasodilation, regulate blood pressure, increase the permeability of blood vessel, thereby suppress formation and the prevention of arterial sclerosis of thrombus.Eating 2 ~ 3 lobe garlics every day, is the preferably the most easy way of step-down, and garlic can help to keep the right quantity of a kind of enzyme in the body and avoid occurring hypertension.
Rabdosia lophanthide: it is sweet, cold in nature to distinguish the flavor of, and function cures mainly clearing heat and promoting diuresis, cool the blood dissipate blood stasis.Control oxyhepatitis, acute cholecystitis, dysentery, enteritis, the retention of urine falls dozen stasis of blood and swells.
Chrysanthemum: the wind heat-clearing of loosing, flat liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, red eye, swell pain, and eyes is dim-sighted.The phenol position of cardiovascular aspect pharmacological action chrysanthemum can increase the guinea pig isolated heart coronary flow, improves mouse to the tolerance energy corn flower power of decompression anoxic, and the heart, liver, the renal function of rabbit do not had the overt toxicity effect.The total extract of chrysanthemum all shows to have positive inotropic action to isolated heart, cardiac muscle cell, and FLOS CHRYSANTHEMI ALBA from Haizhou of China has the rat ventricular that anti-aconitine brings out, and the mouse arrhythmia cordis effect brought out of chloroform.Antivirus action foreign study scholar finds that chrysanthemum is to herpes simplex virus (HSV1), and poliovirus and measles virus have inhibitory action in various degree.In addition, chrysanthemum also has the effect of anti-AIDS, can suppress the activity that ZV reverse transcriptase and HLV copy, and wherein separating the acacetin 7 O β D galactolipins that obtain from chrysanthemum is its active components, and toxicity is very little.The anti-aging effects chrysanthemum can strengthen the glutathione peroxidating and reduce, and obviously prolongs the silkworm life-span; Can also improve mouse heart and brain resisting oxygen lack; the ability that prolongs its life span and remove free radical; someone studies then and finds; chrysanthemum extract has obvious protective effect to biomembranous ultra-oxygen anion free radical damage, mainly is by shielding behind the glyceride that directly enters cell membrane.This new discovery makes chrysanthemum be expected to develop becomes new functional food, especially its effect of performance in antisenility cistanche food.Antiinflammatory action had the researcher just to find that chrysanthemum extract can influence the permeability of mouse capillary as far back as 1950, increased capillary resistance, thereby had antiinflammatory action.In recent years, the foreign scholar finds that after deliberation separation obtains from chrysanthemum triterpene glycol, triol and corresponding palmitate thereof and myristinate have tangible antiinflammatory action to the mouse ear oedema of being brought out by 12O myristoyl phorbol 13 acyls (TPA).Antitumor action separates the taraxerane type triterpene alcohols that obtains from chrysanthemum have than significant inhibitory effect the mouse skin tumour that is caused by TPA; From chrysanthemum, separate 15 triterpene glycol and the triol obtain in addition the BVEA EA that is brought out generation by TPA is all had the obvious suppression effect, wherein 6 compounds carry out the experiment of cell in vitro cytotoxic activity to 60 kinds of human tumor cells such as kinds of tumor such as lung cancer, colon cancer, kidney, oophoroma, the cancer of the brain, leukaemia, found that the leukaemia HL60 cell of compound a rnidiol has extremely significant cytotoxic activity, GI50 is 0.47 μ mol/L.
Honeysuckle: it is sweet, cold in nature to distinguish the flavor of, and goes into the heart, lung, stomach, large intestine channel, and clearing heat and detoxicating effect is arranged, and double can removing heat from the blood and relieve diarrhea is mainly used in affection of exogenous wind-heat, warm heat disease heat poison and contains, or warm disease is from the beginning of heat evil still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; The malicious diarrhea of heat, stool be blood down; Heat temperature card; The sore carbuncle that hot poison gathers is from the beginning of the , inflammation heat person of swelling and ache, and other skin infections, and this thing has antipyretic effect preferably, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis.
Chinese gall: meridian distribution of property and flavor: flavor acid, puckery, cold in nature.Return lung, large intestine, kidney channel.Effect: astringe the lung; Hidroschesis; Puckery intestines; Controlling nocturnal emission with astringent drugs; Hemostasis; Detoxifcation.Cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Protracted dysentery is rushed down for a long time; Prolapse of the anus; Seminal emission; Gonorrhoea; Various hemorrhage; The carbuncle sore furuncle that swells.Astriction: owing to wherein contained tannic acid has precipitation to protein, behind skin, mucous membrane, the ulcer contact tannic acid, its tissue protein namely is solidified, and causes one deck tunicle and is astriction, also oppressed contraction of little blood vessel simultaneously, blood clotting and play hemostasia effect; The protein of gland cell is solidified and causes that secretion suppresses, and produces the mucous membrane drying, and the precipitation of nerve endings protein can be faint local anaesthesia phenomenon.Tannic acid can form not dissolved compound with some metals, alkaloid or glucoside, thereby as antidote.Tannic acid does not have very influence to normal intestinal motility, owing to its astriction alleviates intestinal inflammatory, so can prevent diarrhoea.As there being stimulus such as bacterium, poisonous substance to exist in the intestines and stomach, should not use the tannic acid preparation.Tannic acid what can disturb the absorption (precipitating proteins) of food, but in the alkaline environment of small intestine, protein can be released again, so to contain a small amount of tannic acid in food or the beverage be harmless, but when a large amount of as excessively drinking tea, can delay the absorption of food.Greater amount even can cause stimulation, corrosion can cause pain on an empty stomach, vomit, drops or constipation especially.
The toxicity test of Chinese medicine additive of the present invention:
Take by weighing the Chinese herb feed additive of 300g embodiment 1 preparation, it is added in the 1000g cold water soaked 32 hours, with slow fire boiling, decocting time is 1 hour, and decoction liquor is filtered, and obtains first filtrate; Add again in the 1000g cold water filtering the filter residue that obtains, with slow fire boiling 2 hours, filter and obtain second filtrate; Merge filtrate twice, decompression concentrates removes part water, obtains oral liquid, and the crude drug concentration of oral liquid is 3g/ml.Select the SD rat for use, give variable concentrations (18.0,6.0, the Chinese herb feed additive 1 of embodiments of the invention 1 preparation of 2.0g crude drug/kg), be dissolved in the distilled water, irritate stomach every day twice, sooner or later respectively once, continuous 30 days, respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, after the administration 90 days and carry out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and index inspections such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology.Result of the test shows: the traditional Chinese powder medicine in the embodiment of the invention 1 is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain be no abnormal variation all; Three dosage groups and control group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range (NR), do not have significant difference between group; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat, no clear and definite toxicity target organ and sensitive indicator, convalescence observes and does not also see the retardance toxic reaction, the dosage safety of the Chinese herb feed additive clinical practice among prompting the present invention is higher, having no side effect, is good green medicated premix.
The antibacterial tests of Chinese medicine additive of the present invention:
Choose 100 tail healthy grass carp and be divided into two groups at random, use the feed of grass carp (embodiment group) of the embodiment 1 that contains Chinese medicine additive of the present invention and the feed of grass carp (control group, the traditional Chinese medicine ingredients that is about among the embodiment 1 is removed resulting prescription) of removal Chinese medicine additive composition to feed 50 tails respectively.The equal lumbar injection 105-109cfu/mL of the grass carp of embodiment group and control group visible peristalsis visible intestinal peristalsis point-like aerogenesis monad, every tail 0.2mL bacterium liquid observed for 3 weeks, and the duration of test water temperature is about 28 ℃, records morbidity and the death condition of each experimental group, and the result is as shown in table 1.
Table 1: grass carp morbidity and the death condition table of comparisons
From the data of table 1 as can be known: the grass carp of manually attacking poison of using the mixed feed of the present invention that contains Chinese herb feed additive to feed, its M ﹠ M is starkly lower than the grass carp that does not contain the Chinese medicine additive forage feed.This shows that the Chinese herb feed additive that contains among the present invention obviously has non-special antibacterial action, and enhancing body's immunological function is directly murdered germ, beneficial microbe group in the control agent,
The contrast experiment:
We have set up 30 in Xiantao City Yang Lin tail town innovation village, He Pantan village, Yong He village and have cultured demonstration pilot project.30 demonstration pilot projects are equally divided into three groups at random, the embodiment 1(embodiment group 1 of throwing something and feeding respectively), embodiment 2(embodiment group 2) mixing fish meal and traditional feed of grass carp (control group).By the service technician guidance of regularly following up, and carry out the management accounts of aspects such as fingerling stocking, water quality management, feedstuff feeding, disease prevention and cure.
The pond area is generally at 10-20 mu, depth of water 2-2.5 rice, pond four limit kind grass.Main foster grass carp is raised together with crucian, variegated carp, silver carp, and a small amount of bream is raised together with in the small part pond.The fingerling stocking pattern basically identical (as shown in table 2) in this pond, town.The fingerling release time, went out fish general every year 3-4 time, do the pool end of the year before year or after year.The grass carp survival rate is different and different according to the pond managerial skills, generally between 70-85%, and average every mu of inventory 0.95-1.08 ton/mu.
Wherein, the prescription of traditional feed of grass carp is as follows: rapeseed dregs 34.5%, dregs of beans 15%, the cottonseed dregs of rice 15%, full-cream rice bran 15%, rice bran meal 20%, salt 0.5%.
All data adopt the SPSS13.0 software kit to carry out t(p<0.05) check.The result represents with mean+SD.
Table 2: test tank pond fish kind stocking model situation (unit: mu)
Under the normal condition, grass carp is thrown something and fed 3 times every day, and the time is respectively 8:30 in morning, noon 12:00, afternoon 4:00, day the rate about 3% of throwing something and feeding.The rate of throwing something and feeding day is as shown in table 3:
Table 3: the rate (%) of throwing something and feeding the feed day in grass carp pond reference table
The state that survives and the weightening finish situation that fish raised together with in record in the process of feeding, feed when going out the pool, the total flow of record feed and the output of fish, calculate the economic benefit of total output, feed of grass carp coefficient, full pool feed coefficient and the feed per ton of feed per ton, each experimental group is chosen the survival rate that a pond statistics is raised together with fish, and the result is shown in table 4 and table 5.
Table 4: feed coefficient and feed net production per ton
Annotate: the table intermediate value is mean+SD (n=10); The different letter representation A of similar fingerling, two groups of significant differences of B (p<0.05) in the table.
From the data of table 4 as can be known, use grass carp, bream, crucian, variegated carp and the silver carp of the forage feed of embodiment group 1 and 2, the survival rate of its every kind fish and feed net production per ton all are higher than grass carp, bream, crucian, variegated carp and the silver carp that conventional feed is fed, and its feed of grass carp coefficient all is lower than conventional feed with full pool feed coefficient.
Table 5: the economic benefit of feed per ton
Annotate: listed profit is the profit of the deduction feed cost that brings of feed per ton in the table, does not deduct the daily management cost of feed per ton, as costs such as fishing medicine, artificial, the electricity charge, pool rents.The table intermediate value is mean+SD (n=10), the different letter representation significant differences (p<0.05) of same column.
As can be seen from Table 5, compare with control group, embodiment group 1 and 2 full pool profit, grass carp profit, variegated carp profit and silver carp profit significantly increase, embodiment group 1 has improved 10.4%, 6.5%, 19.6% and 11.9% respectively, embodiment group 2 improved respectively 10.4%, 6.6%, 19.6% and the culturing economic benefit of 13.1%, embodiment group 1 and 2 be improved significantly.
Wherein, the feed formula cost of three kinds of prescriptions is more or less the same, and the terminal price is about 3400 yuan/ton; The market average price of fingerling is as follows: grass carp is that 4.5 yuan/jin, crucian are that 5 yuan/jin, bream are 3 yuan/jin, 3 yuan/jin of variegated carps, 2 yuan/jin of silver carps; The average commercial value in the market of adult fish is as follows: grass carp is that 4.3 yuan/jin, crucian are that 4.8 yuan/jin, bream are 4.8 yuan/jin, 5.0 yuan/jin of variegated carps, 2.2 yuan/jin of silver carps.
By the contrast experiment as can be known, the embodiment of the invention 1 and 2 provides raises together with fish meal, and its feed coefficient is low, feed cost performance height, and the market competitiveness is strong, and full pool remarkable in economical benefits is higher than conventional feed.Wherein, fish that embodiment group 1 and 2 survival rate are fed apparently higher than conventional feed illustrates opposing function and the immunocompetence that fish meal has obviously improved grass carp etc. of raising together with of the present invention.The fish meal of raising together with of the present invention has significantly improved the output of bream, crucian, variegated carp, silver carp under the prerequisite that grass carp output slightly promotes.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.