CN105012673B - A kind of Chinese medicine for preventing domestic animal mycotoxicosis and preparation method thereof - Google Patents
A kind of Chinese medicine for preventing domestic animal mycotoxicosis and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicines for preventing domestic animal mycotoxicosis, it is characterised in that the Chinese medicine is made of the Chinese medicine material of following parts by weight：Radix Glycyrrhizae 80 120, penthorum chinense pursh 80 120, oriental wormwood 60 100, cape jasmine 60 100, Cortex Phellodendri 60 100, rhizoma atractylodis 60 100, root of Chinese trichosanthes 60 100, Radix Glehniae 60 100, Radix Ophiopogonis 60 100, radix scutellariae 40 80, radix bupleuri 40 80, rheum officinale 40 80, talcum 80 120, Chinese herbaceous peony benevolence 40 60.Advantages of the present invention and advantageous effect are：A kind of Chinese prescription for preventing domestic animal mycotoxicosis of present invention offer is reasonable, preparation science, curative for effect, safe without toxic side effect, there is detoxication and toxicant eliminating function, liver protection shield kidney, nourish stomach and intestine, repair damage, can effectively prevent the domestic animals such as pig, ox, sheep mycotoxicosis caused by feed, forage grass etc. go mouldy.It is Ultramicro-powder dosage form to crush Chinese medicine material in Chinese medicinal preparation method of the present invention, enhances medicine stability, clinical efficacy, improves the absorption rate of drug.
Description
Technical field
The invention belongs to veterinary medicine fields, and in particular to a kind of Chinese medicine for preventing domestic animal mycotoxicosis and its preparation side
Method.
Background technology
Mould is the general designation of filamentous fungi, they tend to form branch mycelium in great numbers, but unlike mushroom
Generate large-scale fructification.It substantially can be divided into Aspergillus, Penicillium notatum, Fusarium etc. by attribute.Mycotoxin is then mould
The metabolite generated during growth and breeding on cereal, food and feed, such as fusarium toxin and aflatoxin.It is mould
Verticillium toxin is typically small-molecule substance, and molecular weight is usually hundreds of to several kilodaltons, and it does not have resistance, belongs to thermostabilization
Property substance, will not be destroyed when simply heating, so as to which livestock and poultry or human body usually be caused mycotoxicosis phenomenon occur.Often
See that the maximum mycotoxin of harm has aflatoxin, ochratoxin, zearalenone, vomitoxin, T-2 toxin, cigarette
Aspertoxin and ergotoxin etc..Mycotoxin is one of factor of harm production most serious in livestock culturing industry, and mould is malicious
Plain type is various, and toxin caused by various moulds is different, caused by the extent of injury be also not quite similar.
Mycotoxin jeopardizes domestic animal and human health through a variety of ways.Feed mold generate mycotoxin mainly with
Immunosuppressive mode endangers livestock and poultry and human health, and feed intake, feed conversion rate is caused to decline, and induce in livestock and poultry cultivation
Livestock and poultry, breeding difficulty etc. are the great difficult problems that Present Global herding, feed industry face.The main harm side of mycotoxin
Formula has following several：Mycotoxin directly destroys Immune Organs of Body, causes irreversible immunosupress, so as to induce some viruses
Property disease such as blue otopathy, circovirus, pseudoabies, swine fever；Mycotoxin can generate toxin peptide and promote body drug resistance, by mould
The influence of verticillium toxin, Abwehrkraft des Koepers decline, and are inoculated with after biovaccine by program and cannot get due immunoprotection, and body occurs
The phenomenon that medication treatment also can not receive desired effect after disease；Mycotoxin can destroy the organa parenchymatosum of body, cause each system
Functionally inactive, maximum harm are to cause liver, injury of kidney, reduce liver detoxification function, kidney excretion dysfunction and make whole
A body regulatory function is disorderly；Mycotoxin covers stomach and intestine after concluding：On the one hand enzymatic digestion effect in stomach is reduced, on the other hand
Inhibit intestinal villi activity, nutriment cannot absorb, and cause growth of animal wooden.The mycotoxin remained in livestock products leads to
Influence of the food chain to health is crossed, has caused breeding enterprise, supervision department and the attention of the public.
Domestic animal mycotoxicosis shows as chronic process mostly, also has excessive serious mould feeding (grass) material lost of feeding to cause
Acute poisoning.The chronic animal clinical performance different with acute poisoning is not quite similar, and is described in detail by taking pig, cattle and sheep as an example：Pig
During acute poisoning, spirit is depressed, and appetite is given up absolutely, and body temperature is normal or increases 1 DEG C or so, and excrement is stiff, and the back of a bow of hanging one's head, gait is not
Surely.Some is stood transfixed to the ground, and some excited uneasy, purple plague purpura occurs in salivation, skin surface, has nervous symptoms before dead.During cattle and sheep are acute
Poison is also embodied by affected animal opisthotonos in addition to having above-mentioned symptom, and the enhancing of rumen peristalsis sound, intestines pitch is high, muscle tremors, pain,
Later care for abdomen, diarrhea carries the symptoms such as blood, astasia in excrement.
During pig slow poisoning, loss of appetite, down in spirits, body temperature is normal, becomes thin, and slightly disorderly, skin is blue or gloomy for fur,
It walks powerless, conjunctiva xanthochromia or pale is slow-growing, there is different food phenomenon, and some vomitings are had loose bowels.Later stage is drowsiness, twitch, hind leg
It cannot stand.Cattle and sheep slow poisoning shows as appetite, ruminates reduction, and rumen peristalsis sound weakens, and becomes thin, and walking is powerless, conjunctiva tide
The symptoms such as red or xanthochromia, slow-growing, mouth Tianjin is sticky, and tongue fur is yellow thick, and constipation, urine is short of, and urine color Huang is red.
The present inventor is studied especially for boar mycotoxicosis disease, finds mycotoxicosis to boar
Bigger is injured, nonpregnant sows are out of heat, infertile.Pregnant sow vaginal orifice, vagina swelling, breast enlargement, vagina is deviate from when serious；It is early
Production, miscarriage, production stillborn foetus and weak son etc..Herd boar mammary gland enlargement, Foreskin edema, orchiatrophy, sexual hypoesthesia etc..
The traditional approach of prevention domestic animal mycotoxicosis is to add to take off mould dose in feed, will be mould by suction-operated
Verticillium toxin absorption discharge, but de- mould dose can only absorbed portion mycotoxin, it is impossible to it thoroughly removes, mycotoxin can not be repaired
The body injury brought.The part nutrition essence substance that animal eats can be also adsorbed while using de- mould dose of tradition de- mould,
So as to which animal be made malnutritive situation occur, growth, production capacity is caused to decline.And the mould dose de- of chemical synthesis is used for a long time
There is damage and inhibiting effect to immune cell, irreversible pathology damage can be caused to animal.
It is existing in the prior art that mycotoxicosis is prevented using Chinese medicine composition, it is still, up to the present, existing
Pharmaceutical compositions are more single, and effect is not good enough, it is impossible to pathology damage effectively caused by prevention and reverse mycotoxicosis, because
This needs the Chinese medicine of further research and development prevention domestic animal mycotoxicosis.
Invention content
The object of the present invention is to provide a kind of Chinese medicines for preventing domestic animal mycotoxicosis, and there is detoxication and toxicant eliminating function, liver protection to protect
Kidney nourishes stomach and intestine, repairs the effect of damage, and the Chinese prescription is reasonable, preparation science, curative for effect, safe without toxic side effect energy
Enough effectively prevention domestic animal mycotoxicosis.
It is a further object to provide a kind of preparation methods for the Chinese medicine for preventing domestic animal mycotoxicosis.
The purpose of the present invention is what is realized using following technical scheme, a kind of Chinese medicine for preventing domestic animal mycotoxicosis,
It is characterized in that：The Chinese medicine is made of the Chinese medicine material of following parts by weight：
Radix Glycyrrhizae 80-120, penthorum chinense pursh 80-120, oriental wormwood 60-100, cape jasmine 60-100, Cortex Phellodendri 60-100, rhizoma atractylodis 60-100,
Root of Chinese trichosanthes 60-100, Radix Glehniae 60-100, Radix Ophiopogonis 60-100, radix scutellariae 40-80, radix bupleuri 40-80, rheum officinale 40-80, talcum 80-
120th, Chinese herbaceous peony benevolence 40-60.
Preferably, which is made of the Chinese medicine material of following parts by weight：
Radix Glycyrrhizae 110, penthorum chinense pursh 110, oriental wormwood 90, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 90, Radix Ophiopogonis
90th, radix scutellariae 70, radix bupleuri 70, rheum officinale 70, talcum 110, Chinese herbaceous peony benevolence 55.
Preferably, which is made of the Chinese medicine material of following parts by weight：
Radix Glycyrrhizae 90, penthorum chinense pursh 90, oriental wormwood 80, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 80, Radix Ophiopogonis 80,
Radix scutellariae 60, radix bupleuri 60, rheum officinale 60, talcum 90, Chinese herbaceous peony benevolence 50.
Preferably, which is made of the Chinese medicine material of following parts by weight：
Radix Glycyrrhizae 80, penthorum chinense pursh 80, oriental wormwood 60, cape jasmine 60, Cortex Phellodendri 60, rhizoma atractylodis 60, root of Chinese trichosanthes 60, Radix Glehniae 60, Radix Ophiopogonis 60,
Radix scutellariae 40, radix bupleuri 40, rheum officinale 40, talcum 80, Chinese herbaceous peony benevolence 40.
A kind of preparation method for the Chinese medicine for preventing domestic animal mycotoxicosis, it is characterised in that include the following steps：
(1) by Radix Glycyrrhizae, penthorum chinense pursh, oriental wormwood, cape jasmine, Cortex Phellodendri, rhizoma atractylodis, root of Chinese trichosanthes, Radix Glehniae, Radix Ophiopogonis, radix scutellariae, radix bupleuri, big
Huang, talcum, Chinese herbaceous peony benevolence Chinese medicine material reject impurity, dry, precomminution respectively；
(2) medicinal mixture after precomminution in step (1) with super-micro wall-broken technology is finely smashed, then crosses 500 mesh
Hole sizer to keep raw material Ultramicro-powder grain size at 25 μm or so, and obtains one after sieved powder is sufficiently mixed uniformly in proportion
The Chinese herbal ultra-fine powder preparation of kind prevention domestic animal mycotoxicosis.
Chinese medicine of the present invention can be made into the dosage forms such as ordinary powder, Ultramicro-powder, tablet, oral liquid, but in view of the stabilization of drug
The absorption rate of property, clinical efficacy and drug, preferred dosage form is Ultramicro-powder.
The clinical experimental study of the present inventor's long campaigns herbal control Animal diseases, finds Chinese medicine of the present invention
Composition can be very good prevention domestic animal mycotoxicosis disease.
It is as follows the effect of each component in a kind of prescription for preventing domestic animal mycotoxicosis provided by the invention：
Radix Glycyrrhizae sweet and neutral, enters the heart, spleen, stomach, Liver Channel, clearing heat and detoxicating, relieving spasm to stop pain, and the glycyrrhizin in ingredient is known as very strong
Detoxication, to food poisoning, a variety of drug poisoning, pesticide poisoning, snake venom, interior metabolism product poisoning, anaphylactia
Deng there is a good effect, therefore forefathers' meaning " Radix Glycyrrhizae can solve hundred poison "；Penthorum chinense pursh is sweet, and tepor enters liver and kidney channel, has heat-clearing, profit
The effect of urine, removing toxic substances, promoting blood circulation, soothing the liver, invigorating the spleen, jaundice of dispelling, which includes gallic acid and Quercetin, has liver-protective effective
Ingredient can restore liver function；Oriental wormwood is bitter, pungent, is slightly cold, enters spleen, stomach, Liver Channel, clearing away damp-heat, removing jaundice subcutaneous ulcer, dredging water passages；Cape jasmine is bitter,
It is cold, enter the heart, liver, spleen, stomach, tri-jiao channel, clearing heat-fire, eliminating damp, detoxifying, cooling blood and hemostasis.Four medicines share concurrence liver protection shield kidney, removing toxic substances
The benefits of toxin expelling is main ingredient.
Cortex Phellodendri is bitter, trembles with fear, enters kidney, bladder, spleen, large intestine channel, heat-clearing and damp-drying drug, purging intense heat and detonicating；Rhizoma atractylodis are pungent, bitter, and temperature enters spleen, stomach
Through, it is drying damp and strengthening spleen, with Cortex Phellodendri with, invigorating the spleen fortune wet work(clearing heat and detoxicating with being formed.Root of Chinese trichosanthes is sweet, bitter, is slightly cold, and enters lung, stomach, drop
Fire moisturizes, promote the production of body fluid only drink, apocenosis detumescence；Radix Glehniae, Radix Ophiopogonis are sweet in flavor, are slightly cold, and enter the heart, lung, stomach, heart clearing, lung moistening, nourishing the stomach to improve the production of body fluid,
Inducing diuresis for treating strangurtia has the benefits of similar fluid infusion cardiac stimulant, can protect stomach and intestine, and clear toxin expelling elemen improves Abwehrkraft des Koepers.Five medicine concurrence cardiac stimulants are mended
Liquid nourishes stomach and intestine, improves resistance and tolerance of the body to mycotoxin, helps main ingredient removing toxic substances altogether, the work(of toxin expelling is adjuvant.
Radix scutellariae is bitter, trembles with fear, enters lung, courage, spleen, stomach, heat-clearing and damp-drying drug, purging intense heat and detonicating；Rheum officinale is bitter, trembles with fear, enter spleen, stomach, large intestine,
It is similarly hereinafter controlled in liver, pericardium channel, with radix scutellariae resultant force, clearing heat and removing food stagnation, activating blood circulation and dissipating blood stasis, repairs damage of the toxin to body；Radix bupleuri hardship,
It is pungent, it is slightly cold, enters liver, gallbladder channel, soothing liver-qi stagnation enables it, and it is all adjutant to promote the yang-energy walk help efficacy of a drug without stagnant.Talcum, Chinese herbaceous peony benevolence are sweet, light,
It is cold, enter stomach, kidney, bladder warp, clearing heat and expelling damp, promoting diuresis for stranguria restore aqueous metabolism, and the toxin for the row clearly that promotes to add medicine to can be in time
It excretes to make medicine.
Composition of medicine primary efficacy is：Internal mycotoxin is removed, mycotoxin is repaired and is damaged caused by liver kidney, solved
Except toxic state；Stomach and intestine are nourished in cardiac stimulant fluid infusion, improve resistance and tolerance of the body to mycotoxin；Soothing liver and strengthening spleen, defaecation
Li Shui restores gastrointestinal function and excretes toxin.So as to play the role of effectively preventing domestic animal mycotoxicosis.
It cures mainly：The domestic animals such as pig, ox, sheep mycotoxicosis caused by feed, forage grass etc. go mouldy.Kind can effectively be treated
Pig mycotoxicosis disease：Fertility declines, and nonpregnant sows are out of heat, infertile.Pregnant sow vaginal orifice, vagina swelling, breast
Room enlargement, vagina is deviate from when serious；Premature labor, miscarriage, production stillborn foetus and weak son etc..Herd boar mammary gland enlargement, Foreskin edema, testis wither
Contracting, sexual hypoesthesia etc..Shrinkage is had dry skin, canthus tear spot is serious, is hard and dry, oliguresis color Huang, limb hoof illness.Can have
Effect treatment grower pigs mycotoxicosis disease：Spirit is depressed, tired, loss of appetite, eating green forage apocleisis fine fodder, happiness drink
Water is not swallowed suddenly, and body temperature is abnormal, and skin colour dimness is blue, thick disorderly unglazed, the weakness of limbs of hair, slow-growing, eye conjunctiva tide
Red or xanthochromia, is hard and dry, urine Huang lacks, and progressive emaciation, part pig now vomits, has loose bowels.
Cattle and sheep mycotoxicosis disease can effectively be treated：Appetite ruminates reduction, affected animal opisthotonos, rumen peristalsis
Sound enhances, and intestines pitch is high, and muscle tremors, walk powerless, conjunctiva flush or xanthochromia, slow-growing, mouth Tianjin is sticky, and tongue fur is yellow thick,
Constipation, urine are short of, and urine color Huang is red, and pain later cares for abdomen, diarrhea, and the symptoms such as blood, astasia are carried in excrement.
Other domestic animal mycotoxicosis that drug of the present invention is used to prevent other than pig, cattle and sheep also have significant curative effect.
Advantages of the present invention and advantageous effect are：The present invention provides a kind of Chinese prescription for preventing domestic animal mycotoxicosis
Rationally, preparation science, curative for effect, safe without toxic side effect；Internal mycotoxin can be removed, repairs mycotoxin to liver kidney
Caused by damage, release toxic state；Stomach and intestine are nourished in cardiac stimulant fluid infusion, improve resistance and tolerance of the body to mycotoxin；
Soothing liver and strengthening spleen, defaecation Li Shui restore gastrointestinal function and excrete toxin, so as to play effectively prevention domestic animal mycotoxicosis
Effect.The present invention can effectively prevent the domestic animals such as pig, ox, sheep mycotoxicosis caused by feed, forage grass etc. go mouldy.This
It is Ultramicro-powder dosage form to crush Chinese medicine material in invention Chinese medicinal preparation method, enhances medicine stability, clinical efficacy, improves
The absorption rate of drug.
Specific embodiment
The present invention will be further elucidated by the following examples.It should be noted that：Following embodiments are illustrative, are not
It is limited, it is impossible to limit protection scope of the present invention with following embodiments.
Embodiment one
A kind of Chinese medicine for preventing domestic animal mycotoxicosis, it is characterised in that：Said preparation is former by the Chinese medicine of following parts by weight
Material is made：
Radix Glycyrrhizae 110, penthorum chinense pursh 110, oriental wormwood 90, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 90, Radix Ophiopogonis
90th, radix scutellariae 70, radix bupleuri 70, rheum officinale 70, talcum 110, Chinese herbaceous peony benevolence 55.
A kind of preparation method for the Chinese medicine for preventing domestic animal mycotoxicosis, it is characterised in that include the following steps：
(1) by Radix Glycyrrhizae, penthorum chinense pursh, oriental wormwood, cape jasmine, Cortex Phellodendri, rhizoma atractylodis, root of Chinese trichosanthes, Radix Glehniae, Radix Ophiopogonis, radix scutellariae, radix bupleuri, big
Huang, talcum, Chinese herbaceous peony benevolence Chinese medicine material reject impurity, dry, precomminution respectively；
(2) medicinal mixture after precomminution in step (1) with super-micro wall-broken technology is finely smashed, then crosses 500 mesh
Hole sizer to keep raw material Ultramicro-powder grain size at 25 μm or so, and obtains one after sieved powder is sufficiently mixed uniformly in proportion
The Chinese herbal ultra-fine powder preparation of kind prevention domestic animal mycotoxicosis.
Embodiment two
It is a kind of prevent domestic animal mycotoxicosis Chinese medicine, it is characterised in that the Chinese medicine by following parts by weight Chinese medicine material
It is made：
Radix Glycyrrhizae 90, penthorum chinense pursh 90, oriental wormwood 80, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 80, Radix Ophiopogonis 80,
Radix scutellariae 60, radix bupleuri 60, rheum officinale 60, talcum 90, Chinese herbaceous peony benevolence 50.
The step of preparation method, is the same as embodiment one.
Embodiment three
A kind of Chinese medicine for preventing domestic animal mycotoxicosis, it is characterised in that：Said preparation is former by the Chinese medicine of following parts by weight
Material is made：
Radix Glycyrrhizae 80, penthorum chinense pursh 80, oriental wormwood 60, cape jasmine 60, Cortex Phellodendri 60, rhizoma atractylodis 60, root of Chinese trichosanthes 60, Radix Glehniae 60, Radix Ophiopogonis 60,
Radix scutellariae 40, radix bupleuri 40, rheum officinale 40, talcum 80, Chinese herbaceous peony benevolence 40.
The step of preparation method, is the same as embodiment one.
Clinical practice
In order to verify clinical prevention effect of the drug of the present invention to domestic animal mycotoxicosis, inventor is to because of mycotoxin
The domestic animal of poisoning has carried out test of cure.Subjects are divided into cattle and sheep pig three classes, using drug of the present invention and de- mould dose plus Western medicine
Injection or three white dissipate add Western medicine injection control group to carry out curative effect comparison, so as to evaluate drug of the present invention to domestic animal mycotoxicosis
Control effect.
1st, material and method
1.1 subjects
It is tested respectively from the sick pig of three place acquisition mycotoxicosis, the same this derives from Sichuan Province's Yibin City
The Cheng Zhen Bo of Xingwen County nine are prosperous up to pig farm, which acquires sow 104, every group 52 because the feeding corn that goes mouldy causes pig poisoning
Head, is divided into medicine group of the present invention and de- mould dose adds Western medicine injection control group, and grower pigs 250 are divided into medicine group 130 of the present invention
Head takes off mould dose plus Western medicine injection control group 120；The same this tries to gain certain pig from the cities and towns of Sichuan Province Yibin City Xingwen County nine
, which acquires sow 30 because the feeding wheat bran that goes mouldy causes pig poisoning, every group 15, is divided into medicine group of the present invention and de-
Mould dose plus Western medicine injection control group；Another samples sources are in nine cities and towns in Sichuan Province Yibin City Xingwen County Lu pig farm, the pig farm
Because feeding is gone mouldy pellet poisoning, grower pigs 96 are acquired, every group 48, are divided into medicine group of the present invention and de- mould dose plus Western medicine
Inject control group.
The infected cattle of acquisition mycotoxicosis is tested, and samples sources are in Sichuan Province Yibin City Xingwen County dam township Chen
Cattle farm, the cattle farm acquire ox 36 because feeding is gone mouldy poisoning with spent grains, every group 18, are divided into medicine group of the present invention and three and white dissipate
Western medicine is added to inject control group.
The sick sheep of acquisition mycotoxicosis is tested, and samples sources are in Sichuan Province Yibin City Xingwen County Gu Song towns Luo
Yang Chang, the Yang Chang acquire goat 44 because feeding is gone mouldy poisoning with spent grains, every group 22, are divided into medicine group of the present invention and three and white dissipate
Western medicine is added to inject control group.
1.2 drug usage
50-80 grams/day of pig, 50-80 grams/day of sheep, 250-450 grams/day of ox, weight the lighter take the circumstances into consideration to be reduced, 1 time a day,
7-10 days as one therapeutic course, one course for the treatment of of the lighter's medication, two courses for the treatment of of severe one continuous use.Spice is fed, severe patient's boiling water
It reconstitutes, waits temperature and gavage.
Preventive administration can use drug spice of the present invention to feed, and dosage adds 5-6 kilograms for feed per ton, is within 7-10 days
One course for the treatment of is monthly fed primary.
1.3 test method
Subjects are grouped and processing：
Experiment one
It will be included into drug of the present invention respectively from the nine Si Cheng towns prosperous sick pigs up to pig farm of Bo of Sichuan Province Yibin City Xingwen County
Group and it is de- mould dose plus Western medicine injection control group it is as follows：
I group is tested as de- mould dose plus Western medicine injection group, sick sow 52, medication number of days 14 days, to specifications medication.
II group is tested as medicine group of the present invention, sick sow 52, medication number of days 14 days, according to drug usage explanation of the present invention
Medication.
III group is tested as de- mould dose plus Western medicine injection group, sick grower pigs 120, medication number of days 14 days is used to specifications
Medicine.
IV groups are tested as medicine group of the present invention, sick grower pigs 130, medication number of days 14 days, according to drug usage of the present invention
Illustrate medication.
The sick pig that certain pig farm is tried to gain from the cities and towns of Sichuan Province Yibin City Xingwen County nine is included into medicine group of the present invention respectively
It is as follows with de- mould dose plus Western medicine injection control group：
I group is tested as de- mould dose plus Western medicine injection group, sick sow 15, medication number of days 10 days, to specifications medication.
II group is tested as medicine group of the present invention, sick sow 15, medication number of days 10 days, according to drug usage explanation of the present invention
Medication.
Nine cities and towns in Sichuan Province Yibin City Xingwen County Lu pig farm will be derived from
I group is tested as de- mould dose plus Western medicine injection group, sick grower pigs 48, medication number of days 20 days, to specifications medication.
II group is tested as medicine group of the present invention, sick grower pigs 48, medication number of days 20 days is said according to drug usage of the present invention
Bright medication.
Experiment two
It will be included into medicine group of the present invention respectively from the sick ox of Sichuan Province Yibin City Xingwen County dam township Chen cattle farm
Add Western medicine injection control group as follows with three white dissipate：
It tests I group and adds Western medicine injection group, sick ox 18, medication number of days 14 days, to specifications medication for three white dissipate.
II group is tested as medicine group of the present invention, sick ox 18, medication number of days 14 days, according to drug usage explanation of the present invention
Medication.
Experiment three
It will be included into medicine group of the present invention respectively from the sick goat of Sichuan Province Yibin City Xingwen County Gu Song towns Luo Yang Chang
Add Western medicine injection control group as follows with three white dissipate：
It tests I group and adds Western medicine injection group, sick goat 22, medication number of days 10 days, to specifications medication for three white dissipate.
II group is tested as medicine group of the present invention, sick goat 22, medication number of days 10 days, according to drug usage explanation of the present invention
Medication.
2nd, analysis of clinical symptom
Domestic animal mycotoxicosis shows as chronic process mostly, also has excessive serious mould feeding (grass) material lost of feeding to cause
Acute poisoning.The chronic animal clinical performance different with acute poisoning is not quite similar, and is described in detail by taking pig, cattle and sheep as an example：Pig
During acute poisoning, spirit is depressed, and appetite is given up absolutely, and body temperature is normal or increases 1 DEG C or so, and excrement is stiff, and the back of a bow of hanging one's head, gait is not
Surely.Some is stood transfixed to the ground, and some excited uneasy, purple plague purpura occurs in salivation, skin surface, has nervous symptoms before dead.During cattle and sheep are acute
Poison is also embodied by affected animal opisthotonos in addition to having above-mentioned symptom, and the enhancing of rumen peristalsis sound, intestines pitch is high, muscle tremors, pain,
Later care for abdomen, diarrhea carries the symptoms such as blood, astasia in excrement.
During pig slow poisoning, loss of appetite, down in spirits, body temperature is normal, becomes thin, and slightly disorderly, skin is blue or gloomy for fur,
It walks powerless, conjunctiva xanthochromia or pale is slow-growing, there is different food phenomenon, and some vomitings are had loose bowels.Later stage is drowsiness, twitch, hind leg
It cannot stand.Cattle and sheep slow poisoning shows as appetite, ruminates reduction, and rumen peristalsis sound weakens, and becomes thin, and walking is powerless, conjunctiva tide
The symptoms such as red or xanthochromia, slow-growing, mouth Tianjin is sticky, and tongue fur is yellow thick, and constipation, urine is short of, and urine color Huang is red.
During boar mycotoxicosis, nonpregnant sows are out of heat, infertile.Pregnant sow vaginal orifice, vagina swelling, breast swell
Greatly, vagina is deviate from when serious；Premature labor, miscarriage, production stillborn foetus and weak son etc..Herd boar mammary gland enlargement, Foreskin edema, orchiatrophy,
Sexual hypoesthesia etc..
2.1 criterions of therapeutical effect judge
It cures：The state of mind is good, and appetite, defecation restore normal, other clinical indications disappear, and cure rate=healing number/
Treatment sum.
Effectively：The state of mind is obviously improved, and appetite, defecation take an evident turn for the better, other clinical indications are not eliminated temporarily, efficient
=healing number+significant figure/treatment sum.
2.2 result of the test
Western medicine injection or three is added in vain to drug of the present invention and de- mould dose respectively to the pig, ox, sheep of mycotoxicosis
It dissipates plus Western medicine injection control group is treated, result of the test is as shown below：
Experiment one
Samples sources are as follows in the prosperous result of the tests up to pig farm of Cheng Zhen Bo of Sichuan Province Yibin City Xingwen County nine：
Sow：The cure rate of medicine group of the present invention is 96.2%, and effective percentage is 100%；(production of certain factory is mould dose de- for control group
It is Western medicine is added to inject, for oral administration to take off mould dose of spice and feed, while intramuscular injection Herba Andrographitis, vitamin C respectively) cure rate is 67.3%,
Effective percentage is 76.9%.Grower pigs：The cure rate of medicine group of the present invention is 95.4%, and effective percentage is 98.5%；Control group (certain factory
Produce de- mould dose and add Western medicine injection, de- mould dose of spice for oral administration is fed, as one sees fit interval difference intramuscular injection Herba Andrographitis, vitamin C) it controls
More rate is 70.8%, and effective percentage is 84.2%.
Samples sources are as follows in the result of the test that certain pig farm is tried to gain in the cities and towns of Sichuan Province Yibin City Xingwen County nine：
Sow：The cure rate of medicine group of the present invention is 93.3%, and effective percentage is 100%；(production of certain factory is mould dose de- for control group
Western medicine being added to inject, for oral administration to take off mould dose of spice and feed, interval intramuscular injection Herba Andrographitis, vitamin C respectively as one sees fit) cure rate is
60%, effective percentage is 73.3%.
Result of the test of the samples sources in nine cities and towns in Sichuan Province Yibin City Xingwen County Lu pig farm is as follows：
Grower pigs：The cure rate of medicine group of the present invention is 97.9%, and effective percentage is 100%；(production of certain factory is de- mould for control group
Agent adds Western medicine to inject, for oral administration to take off mould dose of spice and feed, as one sees fit interval intramuscular injection Herba Andrographitis, vitamin C respectively) cure rate is
68.8%, effective percentage is 77.1%.
Experiment two
Result of the test of the samples sources in Sichuan Province Yibin City Xingwen County dam township Chen cattle farm is as follows：
Ox：The cure rate of medicine group of the present invention is 100%, and effective percentage is 100%；(certain factory production three dissipates in vain to be added control group
Western medicine is injected, and three white dissipate gavage, as one sees fit interval intramuscular injection Herba Andrographitis, vitamin C respectively) cure rate is 66.7%, it is efficient
It is 77.8%.
Experiment three
Samples sources are as follows in the result of the test of Sichuan Province Yibin City Xingwen County Gu Song towns Luo Yang Chang：
Sheep：The cure rate of medicine group of the present invention is 95.5%, and effective percentage is 100%；(certain factory production three dissipates in vain to be added control group
Western medicine is injected, and three white dissipate gavage, as one sees fit interval intramuscular injection Herba Andrographitis, vitamin C respectively) cure rate is 68.2%, it is efficient
It is 81.8%.
3rd, interpretation of result
It is analyzed in terms of clinical symptoms and cure rate two, medicine group of the present invention is to pig, cattle and sheep mycotoxicosis
Cure rate and effective percentage are apparently higher than other control groups, and traditional de- mould dose plus Western medicine injection dissipate in vain with three plus Western medicine injection compares
Group has certain therapeutic effect, but significant in efficacy not as good as medicine group of the present invention.Medicament composing prescription of the present invention rationally, preparation science,
Curative for effect, safe without toxic side effect；Internal mycotoxin can be removed, mycotoxin is repaired and is damaged caused by liver kidney, solved
Except toxic state；Stomach and intestine are nourished in cardiac stimulant fluid infusion, improve resistance and tolerance of the body to mycotoxin；Soothing liver and strengthening spleen, defaecation
Li Shui restores gastrointestinal function and excretes toxin, so as to play the role of effectively preventing domestic animal mycotoxicosis.The present invention
The domestic animals mycotoxicosis disease such as pig, ox, sheep can effectively be prevented.
Claims (5)
1. it is a kind of prevent domestic animal mycotoxicosis Chinese medicine, it is characterised in that the Chinese medicine by following parts by weight Chinese medicine material system
Into：
Radix Glycyrrhizae 80-120, penthorum chinense pursh 80-120, oriental wormwood 60-100, cape jasmine 60-100, Cortex Phellodendri 60-100, rhizoma atractylodis 60-100, smallpox
Powder 60-100, Radix Glehniae 60-100, Radix Ophiopogonis 60-100, radix scutellariae 40-80, radix bupleuri 40-80, rheum officinale 40-80, talcum 80-120, vehicle
Preceding benevolence 40-60.
2. a kind of Chinese medicine of prevention domestic animal mycotoxicosis according to claims 1, it is characterised in that the Chinese medicine by
The Chinese medicine material of following parts by weight is made：
Radix Glycyrrhizae 110, penthorum chinense pursh 110, oriental wormwood 90, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 90, Radix Ophiopogonis 90, Huang
A kind of reed mentioned in ancient books 70, radix bupleuri 70, rheum officinale 70, talcum 110, Chinese herbaceous peony benevolence 55.
3. a kind of Chinese medicine of prevention domestic animal mycotoxicosis according to claims 1, it is characterised in that the Chinese medicine by
The Chinese medicine material of following parts by weight is made：
Radix Glycyrrhizae 90, penthorum chinense pursh 90, oriental wormwood 80, cape jasmine 90, Cortex Phellodendri 90, rhizoma atractylodis 90, root of Chinese trichosanthes 90, Radix Glehniae 80, Radix Ophiopogonis 80, radix scutellariae
60th, radix bupleuri 60, rheum officinale 60, talcum 90, Chinese herbaceous peony benevolence 50.
4. a kind of Chinese medicine of prevention domestic animal mycotoxicosis according to claims 1, it is characterised in that the Chinese medicine by
The Chinese medicine material of following parts by weight is made：
Radix Glycyrrhizae 80, penthorum chinense pursh 80, oriental wormwood 60, cape jasmine 60, Cortex Phellodendri 60, rhizoma atractylodis 60, root of Chinese trichosanthes 60, Radix Glehniae 60, Radix Ophiopogonis 60, radix scutellariae
40th, radix bupleuri 40, rheum officinale 40, talcum 80, Chinese herbaceous peony benevolence 40.
5. a kind of preparation method of Chinese medicine for preventing domestic animal mycotoxicosis according to claim 1, it is characterised in that
Include the following steps：
(1) by Radix Glycyrrhizae, penthorum chinense pursh, oriental wormwood, cape jasmine, Cortex Phellodendri, rhizoma atractylodis, root of Chinese trichosanthes, Radix Glehniae, Radix Ophiopogonis, radix scutellariae, radix bupleuri, rheum officinale, cunning
Stone, Chinese herbaceous peony benevolence Chinese medicine material reject impurity, dry, precomminution respectively；
(2) medicinal mixture after precomminution in step (1) with super-micro wall-broken technology is finely smashed, then crosses 500 mesh hole sizers,
And a kind of Chinese herbal ultra-fine powder system for preventing domestic animal mycotoxicosis is obtained after sieved powder is sufficiently mixed uniformly in proportion
Agent.
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| EP3342416A1 (en) * | 2016-12-28 | 2018-07-04 | Erber Aktiengesellschaft | Use of at least one glycyrrhiza plant preparation, an antidote containing same and use of the antidote |
| CN113521155A (en) * | 2021-09-09 | 2021-10-22 | 四川省畜牧科学研究院 | Traditional Chinese medicine composition for treating lacrimation and pore bleeding of sows and application thereof |
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| CN1262109A (en) * | 1999-02-03 | 2000-08-09 | 魏志忠 | Process for preparing Chinese medicine to treat ganorrhea |
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| Title |
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| 《中药治疗奶牛霉菌性胃肠炎》;陈西彦等;《中兽医医药杂志》;20080331(第3期);第67页左栏第2段至右栏第3段 * |
| 中药治疗牛皮肤霉菌病76例;孙荣华;《中兽医医药杂志》;19890430(第04期);第63页第2-4段 * |
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