CN111558011A - Traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis - Google Patents

Traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis Download PDF

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CN111558011A
CN111558011A CN202010543510.9A CN202010543510A CN111558011A CN 111558011 A CN111558011 A CN 111558011A CN 202010543510 A CN202010543510 A CN 202010543510A CN 111558011 A CN111558011 A CN 111558011A
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parts
proventriculitis
chicken
scorched
traditional chinese
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张瑜
张朔生
闫敬来
王一婕
陈珏
常银霞
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Shanxi University of Chinese Mediciine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/02—Breeding vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The invention discloses a traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis, which relates to the field of treatment of chicken proventriculitis, and is prepared by weighing the following medicinal materials in parts by weight: 14-18 parts of scorched hawthorn fruit, 14-18 parts of scorched malt, 14-18 parts of scorched medicated leaven, 3-4 parts of areca nut, 6-8 parts of liquorice, 12-14 parts of tuckahoe, 8-11 parts of bighead atractylodes rhizome, 5-6 parts of dried orange peel, 10-14 parts of astragalus root and 10-14 parts of codonopsis pilosula, all the medicinal materials are mixed and crushed by a crusher to be uniformly distributed, and then the preparation is finished by adopting the sieving operation. The prepared traditional Chinese veterinary medicine powder mixture is added into the feed according to the mass percentage of 0.5-1% of the feed, so that the sick chicken infected with proventriculitis can take the mixture for 10-20 days. The invention takes the veterinary drugs as the entry point, achieves the effect of radically treating the proventriculitis of the chicken by utilizing the special treatment advantages (strengthening body resistance, consolidating superficial resistance and the like) of the traditional Chinese medicines, reduces the use of western antibiotics, does not generate drug resistance, and is beneficial to improving the growth performance and the immunologic function of the broiler chicken.

Description

Traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis
Technical Field
The invention relates to the field of treatment of chicken proventriculitis, in particular to a traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis.
Background
Since the first report in 1994, proventriculitis of chicken has always been one of the most serious epidemic diseases in the production process of poultry industry. A great deal of research has been done by a plurality of scholars at home and abroad about the proventriculitis of the chicken, but the replication of the disease in a laboratory is not easy to succeed, so that the specific cause of the disease is known independently so far, and no conclusion is uniformly determined. Firstly, the cause of the chicken proventriculitis is not clear, so that most researchers or scholars only use antibiotic chemicals to treat sick chickens, and the antibiotics are known to have good treatment effect on bacterial infection but have obvious harm, and too much antibiotics are used to enable killed bacteria to generate drug resistance. Moreover, the drug resistance can be spread mutually, the bacteria can resist certain antibiotics and other antibiotics, and the drug resistance can be spread among different bacteria, bacteria of normal flora of organisms and pathogenic bacteria through drug resistance genes, so that the drug resistance of the bacteria is complicated. And secondly, the excessive abuse of antibiotics can kill a large amount of normal bacteria in the organism, can damage the healthy atmosphere of the organism, reduces the immunity of the organism, allows pathogenic bacteria to enter in the deficiency state and leads the normal organism to die and be irretrievable. Therefore, diagnosis and treatment of chicken proventriculitis and related pharmacodynamic research are diversified in one treatment mode, but the effect is poor, and the aim of accurate and effective treatment cannot be achieved.
In the prior art, as known from the relevant literature, many scholars and researchers have already tried to treat chicken proventriculitis by using veterinary drugs, and the drugs adopted in the prior art, such as stomach invigorating powder, the main components of the stomach invigorating powder comprise: the traditional Chinese medicine composition comprises 15 parts of scorched hawthorn fruit, 15 parts of scorched malt, 15 parts of scorched medicated leaven and 3 parts of betel nut, but the medicinal material has a certain effect of strengthening the body resistance and consolidating the exterior, but the effect on treating the proventriculitis of the chicken is not good as imaginable, and needs to be further enhanced, so that the traditional Chinese medicine composition needs to be improved on the basis of the stomach invigorating powder, veterinary medicines are further developed, and the proventriculitis of the chicken is further deeply researched to achieve the purpose of treating the proventriculitis of the chicken.
Disclosure of Invention
The invention provides a traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis, aiming at solving the problem that the existing stomach invigorating powder has poor effect on treating chicken proventriculitis.
The invention is realized by the following technical scheme: a traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis is prepared by weighing the following medicinal materials in parts by weight: 14-18 parts of scorched hawthorn fruit, 14-18 parts of scorched malt, 14-18 parts of scorched medicated leaven, 3-4 parts of areca nut, 6-8 parts of liquorice, 12-14 parts of tuckahoe, 8-11 parts of bighead atractylodes rhizome, 5-6 parts of dried orange peel, 10-14 parts of astragalus root and 10-14 parts of codonopsis pilosula, all the medicinal materials are mixed and crushed by a crusher to be uniformly distributed, and then the preparation is finished by adopting the sieving operation. On the basis of the stomach invigorating powder, six traditional Chinese medicinal materials of liquorice, tuckahoe, bighead atractylodes rhizome, dried orange peel, astragalus and codonopsis pilosula are added into the traditional Chinese medicine, namely the modified stomach invigorating powder, the effect of strengthening the body resistance and consolidating the constitution is better than that of the stomach invigorating powder, and the traditional Chinese medicine is more precise and scientific by sieving operation.
The invention provides a traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis, which comprises the following application methods: the prepared traditional Chinese veterinary medicine powder mixture is added into the feed according to the mass percentage of 0.5-1% of the feed, so that the sick chicken infected with proventriculitis can take the mixture for 10-20 days. If the disease condition of the sick chicken is too serious, the sick chicken can die, and the sick chicken is not necessarily treated; the disease is not lethal and is essentially cured during this time.
Preferably, the weight parts of the raw materials are as follows: 15 parts of scorched hawthorn fruit, 15 parts of scorched malt, 15 parts of scorched medicated leaven, 3 parts of betel nut, 6 parts of liquorice, 12 parts of tuckahoe, 9 parts of atractylodes macrocephala, 5 parts of dried orange peel, 12 parts of astragalus and 12 parts of codonopsis pilosula.
In order to observe clinical response of the traditional Chinese veterinary medicine, broiler chicken needs to be modeled, and the modeling experiment method comprises the following steps:
① preparing mildew feed by mixing with water at 32 deg.C and humidity of 80% for 5 days to obtain feed containing aflatoxin B1The feed of (1);
secondly, the broiler chickens continuously eat the moldy feed for 10 days, and when the broiler chickens have proventriculitis, the modeling is successful.
And thirdly, the broiler chicken can be clinically tested to detect the effect of the traditional Chinese veterinary medicine: the method is mainly used for carrying out comparison and measurement through three major indexes, namely production performance indexes (average daily feed intake, average daily gain and feed conversion ratio), immune indexes (immunoglobulin content) and morphological indexes (the shapes of chicken stomach and glandular stomach).
In modeling, when preparing the mildew feed, the pathogenic aflatoxin B is obtained1The content of (B) was 46.11 ug/kg.
Compared with the prior art, the invention has the following beneficial effects: the traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis and the application method thereof provided by the invention have the advantages that the traditional Chinese veterinary medicine is used as an entry point, the effect of radically treating the chicken proventriculitis is achieved by utilizing the special treatment advantages (such as supporting the body resistance and consolidating the exterior and the like) of the traditional Chinese medicine, the use of western medicine antibiotics is reduced, and the drug resistance cannot be generated.
Drawings
Fig. 1 is a histopathology diagram of glandular stomach glands of cured broiler chickens.
FIG. 2 is a histopathology diagram of the cuticular membrane of the glandular stomach gland of a cured broiler chicken.
FIG. 3 is a histopathological diagram of glandular stomach tubules of broiler chickens with chicken proventriculitis.
FIG. 4 is a histopathological diagram of myogastric cuticle membranes of broiler chickens with chicken proventriculitis.
Detailed Description
The present invention is further illustrated by the following specific examples.
A traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis: weighing the following medicinal materials in parts by weight: 14-18 parts of scorched hawthorn fruit, 14-18 parts of scorched malt, 14-18 parts of scorched medicated leaven, 3-4 parts of areca nut, 6-8 parts of liquorice, 12-14 parts of tuckahoe, 8-11 parts of bighead atractylodes rhizome, 5-6 parts of dried orange peel, 10-14 parts of astragalus root and 10-14 parts of codonopsis pilosula, all the medicinal materials are mixed and crushed by a crusher to be uniformly distributed, and then the preparation is finished by adopting the sieving operation.
5 test groups are set, wherein the stomach strengthening powder is adopted in the test 1 group, the flavored stomach strengthening powder is adopted in the tests 2-4 groups, the basic ration is adopted in the test 5 group, and the specific groups are set as shown in the table 1.
In the experiment 1 group, the stomach invigorating powder comprises the following traditional Chinese medicine raw materials in proportion: 15g of scorched hawthorn, 15g of scorched malt, 15g of scorched medicated leaven and 3g of betel nut; in the group, the addition ratio of the stomach invigorating powder on the basic ration is 0.5%.
In the examples of the experiment 2-4 groups, the modified stomach-invigorating powder is prepared from the following traditional Chinese medicine raw materials in proportion: the raw materials comprise 15g of scorched hawthorn, 15g of scorched malt, 15g of scorched medicated leaven, 3g of betel nut, 6g of liquorice, 12g of tuckahoe, 9g of atractylodes macrocephala, 5g of dried orange peel, 12g of astragalus and 12g of codonopsis pilosula, which are uniformly mixed and then crushed by a crusher to ensure that the mixture is distributed more evenly and the error is reduced, and then the sieving operation is carried out. Adding the prepared traditional Chinese veterinary medicine powder mixture into the feed according to the mass percentage of 0.5-1% of the feed, and adding the traditional Chinese veterinary medicine powder mixture into the feed in the test group 2 according to the mass percentage of 0.5%; test 3, add 0.75%; test 4, add 1.0%; the medicine is taken by sick chicken infected with proventriculitis for 10-20 days.
Test 5 group was a control group.
The modeling experiment method of the sick chicken comprises the following steps:
① preparing mildew feed containing aflatoxin B by mixing at 32 deg.C and humidity of 80% for 5 days with water content of 20% for 2 times per day, and oven drying1The content of the obtained pathogenic aflatoxin B1 is 46.11 ug/kg;
secondly, the broiler chickens continuously eat the moldy feed for 10 days, and when the broiler chickens have proventriculitis, the modeling is successful.
TABLE 1 group settings
Figure 363127DEST_PATH_IMAGE001
By contrast, the various embodiments mainly perform comparative measurement by three major indexes, namely, production performance indexes (average daily feed intake, average daily gain, feed conversion ratio), immunity indexes (immunoglobulin content) and morphology indexes (the morphology of chicken stomach and glandular stomach).
From fig. 1 and fig. 2, it can be seen that the muscular stomach and glandular stomach of the sick chicken in the test groups 1-4 are basically recovered to be normal, which shows that the stomach invigorating powder and the flavored stomach invigorating powder have the efficacy of treating the glandular gastritis, but the subsequent comparison of various indexes is also needed. From fig. 3 and 4 it can be seen that the broilers of the group 5 tested had typical symptoms of chicken proventriculitis.
The results of the production performance index and the immunity index after the multiple comparisons are shown in tables 2 and 3:
TABLE 2 comparison of the Performance of broilers in each group
Figure 135911DEST_PATH_IMAGE002
TABLE 3 broiler immunoglobulin comparison (μ g/mL) of groups
Figure 942193DEST_PATH_IMAGE003
And (4) experimental conclusion: the drug test shows that the feed is added with 0.5 percent of stomach strengthening powder, 0.5 percent of modified stomach strengthening powder, 0.75 percent of modified stomach strengthening powder and 1 percent of modified stomach strengthening powder, which can effectively treat the proventriculitis of chickens caused by the aflatoxin B1 and can effectively improve the intestinal health of the broilers. The effect of improving the growth performance of the broiler is the best by 0.75 percent of the modified stomach strengthening powder, and the IgG content can be obviously improved by 0.75 percent and 1 percent of the modified stomach strengthening powder; 0.75 percent of flavored stomach invigorating powder can obviously improve the content of IgM; both 0.75% and 1% flavored stomach invigorating powder can significantly improve the IgA content. In conclusion, the flavored stomach invigorating powder with the amount of 0.75 percent is added into the daily ration, so that the growth performance and the immune function of the broiler are improved.
The scope of the invention is not limited to the above embodiments, and various modifications and changes may be made by those skilled in the art, and any modifications, improvements and equivalents within the spirit and principle of the invention should be included in the scope of the invention.

Claims (5)

1. A traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis is characterized in that: weighing the following medicinal materials in parts by weight:
14-18 parts of scorched hawthorn fruit, 14-18 parts of scorched malt, 14-18 parts of scorched medicated leaven, 3-4 parts of areca nut, 6-8 parts of liquorice, 12-14 parts of tuckahoe, 8-11 parts of bighead atractylodes rhizome, 5-6 parts of dried orange peel, 10-14 parts of astragalus root and 10-14 parts of codonopsis pilosula, all the medicinal materials are mixed and crushed by a crusher to be uniformly distributed, and then the preparation is finished by adopting the sieving operation.
2. The veterinary drug for preventing and treating proventriculitis of chicken as claimed in claim 1, is characterized in that: the weight parts of the raw materials are as follows: 15 parts of scorched hawthorn fruit, 15 parts of scorched malt, 15 parts of scorched medicated leaven, 3 parts of betel nut, 6 parts of liquorice, 12 parts of tuckahoe, 9 parts of atractylodes macrocephala, 5 parts of dried orange peel, 12 parts of astragalus and 12 parts of codonopsis pilosula.
3. The application of the veterinary drug for preventing and treating proventriculitis of chicken, disclosed by claim 1, is characterized in that: the prepared traditional Chinese veterinary medicine powder mixture is added into the feed according to the mass percentage of 0.5-1% of the feed, so that the sick chicken infected with proventriculitis can take the mixture for 10-20 days.
4. The modeling experiment method for the chicken proventriculitis of the veterinary medicine for preventing and treating the chicken proventriculitis, which is disclosed by claim 1, is characterized in that: the method comprises the following steps:
① preparing mildew feed containing aflatoxin B by mixing at 32 deg.C and humidity of 80% for 5 days with water content of 20% for 2 times per day, and oven drying1The feed of (1);
secondly, the broiler chickens continuously eat the moldy feed for 10 days, and when the broiler chickens have proventriculitis, the modeling is successful.
5. The modeling experiment method for chicken proventriculitis of the veterinary drug for preventing and treating chicken proventriculitis as claimed in claim 4, wherein in step ①, pathogenic aflatoxin B1The content of (B) was 46.11 ug/kg.
CN202010543510.9A 2020-06-15 2020-06-15 Traditional Chinese veterinary medicine for preventing and treating chicken proventriculitis Pending CN111558011A (en)

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CN115381874A (en) * 2022-07-11 2022-11-25 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medicine composition and granules for treating chicken non-infectious diarrhea and preparation method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115381874A (en) * 2022-07-11 2022-11-25 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medicine composition and granules for treating chicken non-infectious diarrhea and preparation method
CN115381874B (en) * 2022-07-11 2024-02-20 中国农业科学院兰州畜牧与兽药研究所 Traditional Chinese medicine composition and granule for treating chicken noninfectious diarrhea and preparation method thereof

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Application publication date: 20200821