CN101670061A - Veterinary drug for treating respiratory tract infection of poultry and preparation method thereof - Google Patents
Veterinary drug for treating respiratory tract infection of poultry and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a veterinary drug for treating respiratory tract infection of poultry and a preparation method thereof. The veterinary drug is prepared mainly from the following materials by weight part: 30-120 parts of radix stemonae, 10-120 parts of scutellaria baicalensis, 30-210 parts of giant knot weed, 10-60 parts of indigo naturalis, 10-60 parts of artificial bezoar, 10-40 parts ofborneol, 10-90 parts of realgar, 10-60 parts of liquorice, 30-120 parts of platycodon root, 90-210 parts of cyrtomium fortunei, 30-120 parts of blackberry lily, 10-210 parts of dried toad, 150-420 parts of radix isatidis and 1-10 parts of bromhexine hydrochloride. The veterinary drug is prepared by grinding, screening and evenly mixing the materials, and grinding the materials by a superfine pulverizing technology into submicron powder and packing. The veterinary drug is mainly used for treating respiratory diseases of poultry caused by the bacterial viruses such as infectious bronchitis of chicken, infectious laryngotracheitis, newcastle disease and influenza. The invention has the advantages of rapid drug effect, favorable effect and little remaining charge, has simple preparation methodand is easy for promotion and application.
Description
Technical field
The present invention relates to a kind of veterinary drug, particularly a kind of veterinary drug for the treatment of livestock and poultry respiratory tract infection and preparation method thereof.
Background technology
Expansion along with the intensive culture scale, add that raiser's breed level is uneven, lack comprehensive feeding and management and epidemic prevention and control knowledge, in recent years, fowl infection respiratory system disease was more and more serious, had had influence on weightening finish and efficiency of feed utilization, laying rate also descends thereupon, the carcass quality degradation, even cause a considerable amount of death, make culturist's economic benefit be subjected to serious threat.Yet the respiratory tract disease of fowl is more complicated in foster fowl produces, and kinds of Diseases are a lot, have virus to cause, have antibacterial and mycoplasma to cause, M ﹠ M does not wait yet.At present, the respiratory tract disease that has a strong impact on fowl poultry kind production mainly contains the livestock and birds respiratory disease that bacterial viruses such as infectious bronchitis of chicken, infectious laryngotracheitis, newcastle, influenza cause.Traditional Therapeutic Method is to use antiviral drugs and antibiotics in a large number, though when beginning effect obvious, along with the Resistant strain of antibacterial in recent years is more and more, drug-resistance of bacteria strengthens, it is very undesirable that effect becomes.Abuse antiviral drugs and antibiotics simultaneously drug residue is exceeded standard, influence food quality, and then influence human body health.The use that is under an embargo successively of present many antiviral classes and antibiotics Western medicine adopts the treatment by Chinese herbs livestock and birds respiratory disease to become one of effective treatment means.
Summary of the invention
The object of the present invention is to provide a kind of veterinary drug for the treatment of livestock and poultry respiratory tract infection, it is fast to have drug effect, effective, the residual few characteristics of medicine.
To achieve these goals, the present invention is by the following technical solutions:
A kind of veterinary drug for the treatment of livestock and poultry respiratory tract infection is mainly made by the raw material of following parts by weight: 30~120 parts of the Radixs Stemonae, 10~120 parts of Radix Scutellariaes, 30~210 parts of Rhizoma Polygoni Cuspidati, 10~60 parts of Indigo Naturaliss, 10~60 parts of artificial Calculus Boviss, 10~40 parts of Borneolum Syntheticums, 10~90 parts of Realgars, 10~60 parts in Radix Glycyrrhizae, 30~120 parts of Radix Platycodoniss, 90~210 parts of Rhizoma Osmundae, 30~120 parts of Rhizoma Belamcandae, 10~210 parts of Bufo siccus, 150~420 parts of Radix Isatidis, 1~10 part of Bisolvon.
The parts by weight of primary raw material are preferably: 60~100 parts of the Radixs Stemonae, 40~90 parts of Radix Scutellariaes, 80~150 parts of Rhizoma Polygoni Cuspidati, 20~50 parts of Indigo Naturaliss, 20~45 parts of artificial Calculus Boviss, 20~35 parts of Borneolum Syntheticums, 30~80 parts of Realgars, 20~50 parts in Radix Glycyrrhizae, 50~110 parts of Radix Platycodoniss, 100~180 parts of Rhizoma Osmundae, 60~100 parts of Rhizoma Belamcandae, 100~170 parts of Bufo siccus, 200~350 parts of Radix Isatidis, 3~7 parts of Bisolvon.
Parts by weight the best of primary raw material is: 90 parts of the Radixs Stemonae, 60 parts of Radix Scutellariaes, 130 parts of Rhizoma Polygoni Cuspidati, 30 parts of Indigo Naturaliss, 24 parts of artificial Calculus Boviss, 30 parts of Borneolum Syntheticums, 50 parts of Realgars, 40 parts in Radix Glycyrrhizae, 70 parts of Radix Platycodoniss, 120 parts of Rhizoma Osmundae, 80 parts of Rhizoma Belamcandae, 150 parts of Bufo siccus, 270 parts of Radix Isatidis, 6 parts of Bisolvon.
The present invention selects for use the effect of raw material to be summarized as follows:
(1) Radix Stemonae: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing is used for new chronic cough and coughs, pulmonary tuberculosis cough, pertussis;
(2) Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication is used for hygropyrexia, the cough due to lung-heat;
(3) Rhizoma Polygoni Cuspidati: expelling wind and removing dampness, the dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm is used for hygropyrexia, cough with copious phlegm;
(4) Indigo Naturalis: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion is used for the temperature poison, chest pain hemoptysis, sore throat;
(5) artificial Calculus Bovis: heat clearing away, detoxifcation is reduced phlegm, and arresting convulsion is used for expectorant heat, laryngopharynx swelling and pain, aphtha of the mouth and tongue;
(6) Borneolum Syntheticum: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain is used for the calentura coma, aphtha, laryngopharynx swelling and pain;
(7) Realgar: the detoxifcation parasite killing, removing dampness and eliminating phlegm, preventing the attack (or recurrence) of malaria is used for the carbuncle furuncle, abdominal pain due to worm stagnation, malaria;
(8) Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain;
(9) Radix Platycodonis: lung qi dispersing, sore-throat relieving eliminates the phlegm, and evacuation of pus is used for cough with copious phlegm, pharyngalgia;
(10) Rhizoma Osmundae: heat-clearing and toxic substances removing, anthelmintic;
(11) Rhizoma Belamcandae: heat-clearing and toxic substances removing, expectorant, sore-throat relieving is used for the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, cough and asthma;
(12) Bufo siccus: subduing swelling and detoxicating, pain relieving, diuresis is used for chronic tracheitis, laryngopharynx swelling and pain;
(13) Radix Isatidis: heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving is used for sore throat, scarlet fever;
(14) Bisolvon: can directly act on the bronchus body of gland, impel the lysosome of mucous secreting cell to disengage, make the sticking sugared fiber differentiation cracking of apoplexy due to phlegm; Also can suppress the synthetic of acidoglycoprotein in mucous gland and the goblet cell, make it to secrete the lower micro-molecule glucoprotein of viscosity, thereby the viscosity of sputum is reduced, be easy to expectoration; In addition, also can stimulate gastric mucosa reflexive ground to cause that the respiratory tract glandular secretion increases, make the sputum dilution, in order to avoid sticking expectorant such as bronchitis, asthma, emphysema are difficult for expectoration.
The veterinary drug that the present invention treats livestock and poultry respiratory tract infection is on the basis of China's tradition Chinese patent medicine " LIUSHEN WAN ", gets through changing agent, and be a kind of Chinese medicine and western medicine bound drug.In the present invention; Radix Scutellariae, Rhizoma Polygoni Cuspidati, Indigo Naturalis, Radix Isatidis, Rhizoma Belamcandae, artificial Calculus Bovis are principal agent altogether; effect with heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Realgar, Borneolum Syntheticum, Bufo siccus, Rhizoma Osmundae help principal agent heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling, the rotten pain relieving of change; assistant is reduced phlegm with Radix Platycodonis, stemona root cough relieving; Radix Glycyrrhizae expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription, bromhexine hydrochloride can reduce the viscosity of sputum, makes it to be easy to expectoration.
The present invention also provides a kind of preparation method for the treatment of the veterinary drug of livestock and poultry respiratory tract infection, and its preparation method is:
(1) takes by weighing each raw material by weight, pulverize the back and cross 40 mesh sieves;
(2) insert in the mixer and stir, fully mixing;
(3) pulverize through superfine communication technique, packing gets finished product.
Advantage of the present invention: drug effect is fast, and therapeutic effect is good, has no side effect, and does not influence food quality; Preparation method is simple, be easy to promote and produce.
The specific embodiment
Embodiment 1
Take by weighing raw material by following parts by weight: 30 parts of the Radixs Stemonae, 10 parts of Radix Scutellariaes, 30 parts of Rhizoma Polygoni Cuspidati, 10 parts of Indigo Naturaliss, 10 parts of artificial Calculus Boviss, 10 parts of Borneolum Syntheticums, 10 parts of Realgars, 10 parts in Radix Glycyrrhizae, 30 parts of Radix Platycodoniss, 90 parts of Rhizoma Osmundae, 30 parts of Rhizoma Belamcandae, 10 parts of Bufo siccus, 150 parts of Radix Isatidis, 1 part of Bisolvon.
Preparation method is as follows:
(1) puts into pulverizer together, pulverize the back and cross 40 mesh sieves;
(2) insert in the mixer again and stir, fully mixing;
(3) pulverize through superfine communication technique, powder is made in packing.
Embodiment 2
Take by weighing raw material by following parts by weight: 120 parts of the Radixs Stemonae, 120 parts of Radix Scutellariaes, 210 parts of Rhizoma Polygoni Cuspidati, 60 parts of Indigo Naturaliss, 60 parts of artificial Calculus Boviss, 40 parts of Borneolum Syntheticums, 90 parts of Realgars, 60 parts in Radix Glycyrrhizae, 120 parts of Radix Platycodoniss, 210 parts of Rhizoma Osmundae, 120 parts of Rhizoma Belamcandae, 210 parts of Bufo siccus, 420 parts of Radix Isatidis, 10 parts of Bisolvon.
Preparation method is with embodiment 1.
Embodiment 3
Take by weighing raw material by following parts by weight: 60 parts of the Radixs Stemonae, 40 parts of Radix Scutellariaes, 80 parts of Rhizoma Polygoni Cuspidati, 20 parts of Indigo Naturaliss, 20 parts of artificial Calculus Boviss, 20 parts of Borneolum Syntheticums, 30 parts of Realgars, 20 parts in Radix Glycyrrhizae, 50 parts of Radix Platycodoniss, 100 parts of Rhizoma Osmundae, 60 parts of Rhizoma Belamcandae, 100 parts of Bufo siccus, 200 parts of Radix Isatidis, 3 parts of Bisolvon.
Preparation method is with embodiment 1.
Embodiment 4
Take by weighing raw material by following parts by weight: 100 parts of the Radixs Stemonae, 90 parts of Radix Scutellariaes, 150 parts of Rhizoma Polygoni Cuspidati, 50 parts of Indigo Naturaliss, 45 parts of artificial Calculus Boviss, 35 parts of Borneolum Syntheticums, 80 parts of Realgars, 50 parts in Radix Glycyrrhizae, 110 parts of Radix Platycodoniss, 180 parts of Rhizoma Osmundae, 100 parts of Rhizoma Belamcandae, 170 parts of Bufo siccus, 350 parts of Radix Isatidis, 7 parts of Bisolvon.
Preparation method is with embodiment 1.
Embodiment 5
Take by weighing raw material by following parts by weight: 90 parts of the Radixs Stemonae, 60 parts of Radix Scutellariaes, 130 parts of Rhizoma Polygoni Cuspidati, 30 parts of Indigo Naturaliss, 24 parts of artificial Calculus Boviss, 30 parts of Borneolum Syntheticums, 50 parts of Realgars, 40 parts in Radix Glycyrrhizae, 70 parts of Radix Platycodoniss, 120 parts of Rhizoma Osmundae, 80 parts of Rhizoma Belamcandae, 150 parts of Bufo siccus, 270 parts of Radix Isatidis, 6 parts of Bisolvon.
Preparation method is with embodiment 1.
The medication of this medicine is a feeding, and ampoule is the poultry feeding 0.05g of every 1kg body weight, and once-a-day, three is a course of treatment.
Below with concrete description of test effect of the present invention:
One, veterinary drug of the present invention is to the clinical trial of the sick chicken treatment of natural infection infectious laryngotracheitis of chicken (ILT)
1. test drug
For the reagent product is the powder that embodiment 1, embodiment 4, embodiment 5 make, and using dosage is every sick chicken 0.05g every day.
2. chicken is used in treatment
Select two batches of sick chickens, a collection of is the AA broiler, and 1600, another batch is the blue brown laying hen in sea, 1600, and totally 3200.
Pathogen separation and evaluation: sick chicken larynx and the homogenate supernatant inoculation SPF of tracheal tissue Embryo Gallus domesticus have typical pox speckle to form on its allantocherion; The pathological material of disease separator through immune agar gel diffusion test, forms precipitation line clearly between sample well to be checked and central standard positive serum hole after the breeding of Embryo Gallus domesticus fine hair allantoic cavity, concentrating, thereby contain ILTV in the judgement separator.
Differentiate in conjunction with Epidemiological study and clinical symptoms again, prove that disease that this two batches of sick chickens take a disease is ILT.
3. therapeutic effect
3.1. therapeutic effect to AA broiler infectious laryngotracheitis (ILT)
1600 sick chickens are equally divided into four groups, are respectively matched group, take embodiment 1 medicine group, take embodiment 4 medicine groups and take embodiment 5 medicine groups, and wherein the sick chicken of matched group is not taken any medicine.
After sick chicken was taken embodiment 1 medicine, embodiment 4 medicines and embodiment 5 medicines, the state of an illness was very fast controlled, and case fatality rate significantly is lower than matched group.Particularly embodiment 4, embodiment 5 medicine group therapeutic effect are obvious, take 1 day after, the state of an illness is tending towards alleviating gradually, sick chicken essence god is faded in vivaciously, movable increasing, appetite improvement; Dyspnea improves after 2 days, and wet sound of vomiting sound weakens with the sound of stridulating, and cough alleviates, and sick chicken stops death, and clinical symptoms greatly alleviates; Sick chicken symptom disappears substantially after 3 days, and it is normal that the diet desire is recovered.Statistical result shows that untreated matched group spontaneous recovery rate is 85.25%, though fatality rate is not high, but symptom is eliminated slowly, the cure rate of 3 veterinary drug embodiment groups of the present invention is all more than 97%, and case fatality rate significantly is lower than matched group (P<0.01), and symptom is eliminated very fast.Concrete correction data sees Table 1.
Table 1 the present invention is to the therapeutic effect data of AA broiler infectious laryngotracheitis (ILT)
Group | Sick chicken number (only) | Death toll (only) | Case fatality rate (%) | Cure number (only) | Cure rate (%) |
Matched group | ??400 | ??59 | ??14.75 | ??341 | ??85.25 |
Take embodiment 1 medicine group | ??400 | ??9 | ??2.25 | ??391 | ??97.75 |
Take embodiment 4 medicine groups | ??400 | ??3 | ??0.75 | ??397 | ??99.25 |
Take embodiment 5 medicine groups | ??400 | ??4 | ??1.00 | ??396 | ??99.00 |
3.2. therapeutic effect to the blue brown laying hen infectious laryngotracheitis in sea (ILT)
1600 sick chickens are equally divided into four groups, are respectively matched group, take embodiment 1 medicine group, take embodiment 4 medicine groups and take embodiment 5 medicine groups, and wherein the sick chicken of matched group is not taken any medicine.
After sick chicken is taken embodiment 1 medicine, embodiment 4 medicines and embodiment 5 medicines, the state of an illness is very fast controlled, from beginning in the 2nd day, spirit was faded in vivaciously, movable increasing, appetite takes a turn for the better, dyspnea improves, and wet sound of vomiting sound weakens with the sound of stridulating, and cough alleviates, the 3rd day symptom disappears substantially after the medication, and it is normal that the diet desire is recovered.Statistical result shows that the cure rate of 3 veterinary drug embodiment groups of the present invention is all more than 98%, and case fatality rate significantly is lower than matched group (P<0.01).Concrete correction data sees Table 2.
Table 2 the present invention is to the therapeutic effect data of the blue brown laying hen infectious laryngotracheitis in sea (ILT)
Group | Sick chicken number (only) | Death toll (only) | Case fatality rate (%) | Cure number (only) | Cure rate (%) |
Matched group | ??400 | ??53 | ??13.25 | ??347 | ??86.75 |
Take embodiment 1 medicine group | ??400 | ??6 | ??1.50 | ??394 | ??98.50 |
Take embodiment 4 medicine groups | ??400 | ??3 | ??0.75 | ??397 | ??99.25 |
Take embodiment 5 medicine groups | ??400 | ??3 | ??0.75 | ??397 | ??99.25 |
Variation has also taken place in sick laying rate of chicken before and after the treatment, and chicken group premorbid laying rate is 90.67%, and the beginning in the 4th day of morbidity back sharply descends, and drops to about 60% when serious.After sick chicken is taken embodiment 1 medicine, embodiment 4 medicines and embodiment 5 medicines, laying rate is able to rapid recovery, the sick laying rate of chicken of particularly taking embodiment 4, embodiment 5 medicines recovers particularly evident, promptly return to the preceding level of disease the 3rd week substantially, and matched group just returns to 77.12% until the 5th week.Concrete data see Table 3.
Table 3 is respectively organized the time dependent statistical data of disease laying rate of chicken
Group | Sick chicken number (only) | The 7th day laying rate (%) | The 14th day laying rate (%) | The 21st day laying rate (%) | The 28th day laying rate (%) | The 35th day laying rate (%) |
Matched group | ??400 | ??67.80 | ??66.95 | ??68.64 | ??71.19 | ??77.12 |
Take embodiment 1 medicine group | ??400 | ??67.91 | ??70.15 | ??81.34 | ??84.33 | ??88.06 |
Take embodiment 4 medicine groups | ??400 | ??68.15 | ??74.07 | ??85.93 | ??88.89 | ??91.11 |
Take embodiment 5 medicine groups | ??400 | ??67.41 | ??73.33 | ??85.19 | ??87.40 | ??90.37 |
4. discussion of results
(1) the infectious laryngotracheitis chicken of selected two batches of natural occurrences is after taking veterinary drug of the present invention, the state of an illness is very fast controlled, case fatality rate significantly is lower than matched group, sick chicken symptom disappears substantially after 3 days, it is normal that the diet desire is recovered, and the result shows that it is highly effective that veterinary drug of the present invention is used for the treatment of infectious laryngotracheitis of chicken (ILT).
(2) infectious laryngotracheitis of chicken (ILT) is serious to the egg laying performance influence of laying hen, generally can make laying rate descend 12%~62%.After sick chicken was taken veterinary drug of the present invention, laying rate was able to rapid recovery, showed that veterinary drug of the present invention can not only effectively treat infectious laryngotracheitis of chicken (ILT), and can recover the egg laying performance of laying hen rapidly, effectively reduced the economic loss that disease is brought.
Claims (4)
1, a kind of veterinary drug for the treatment of livestock and poultry respiratory tract infection; it is characterized in that, mainly make: 30~120 parts of the Radixs Stemonae, 10~120 parts of Radix Scutellariaes, 30~210 parts of Rhizoma Polygoni Cuspidati, 10~60 parts of Indigo Naturaliss, 10~60 parts of artificial Calculus Boviss, 10~40 parts of Borneolum Syntheticums, 10~90 parts of Realgars, 10~60 parts in Radix Glycyrrhizae, 30~120 parts of Radix Platycodoniss, 90~210 parts of Rhizoma Osmundae, 30~120 parts of Rhizoma Belamcandae, 10~210 parts of Bufo siccus, 150~420 parts of Radix Isatidis, 1~10 part of Bisolvon by the raw material of following parts by weight.
2, the veterinary drug of treatment livestock and poultry respiratory tract infection according to claim 1; it is characterized in that the parts by weight of primary raw material are preferably: 60~100 parts of the Radixs Stemonae, 40~90 parts of Radix Scutellariaes, 80~150 parts of Rhizoma Polygoni Cuspidati, 20~50 parts of Indigo Naturaliss, 20~45 parts of artificial Calculus Boviss, 20~35 parts of Borneolum Syntheticums, 30~80 parts of Realgars, 20~50 parts in Radix Glycyrrhizae, 50~110 parts of Radix Platycodoniss, 100~180 parts of Rhizoma Osmundae, 60~100 parts of Rhizoma Belamcandae, 100~170 parts of Bufo siccus, 200~350 parts of Radix Isatidis, 3~7 parts of Bisolvon.
3, the veterinary drug of treatment livestock and poultry respiratory tract infection according to claim 2; it is characterized in that parts by weight the best of primary raw material is: 90 parts of the Radixs Stemonae, 60 parts of Radix Scutellariaes, 130 parts of Rhizoma Polygoni Cuspidati, 30 parts of Indigo Naturaliss, 24 parts of artificial Calculus Boviss, 30 parts of Borneolum Syntheticums, 50 parts of Realgars, 40 parts in Radix Glycyrrhizae, 70 parts of Radix Platycodoniss, 120 parts of Rhizoma Osmundae, 80 parts of Rhizoma Belamcandae, 150 parts of Bufo siccus, 270 parts of Radix Isatidis, 6 parts of Bisolvon.
4, a kind of preparation method of veterinary drug of treatment livestock and poultry respiratory tract infection as claimed in claim 1 is characterized in that, its preparation method is:
(1) takes by weighing each raw material by weight, pulverize the back and cross 40 mesh sieves;
(2) insert in the mixer and stir, fully mixing;
(3) pulverize through superfine communication technique, packing gets finished product.
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Cited By (5)
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CN104383133A (en) * | 2014-10-23 | 2015-03-04 | 郑州后羿制药有限公司 | Traditional Chinese medicine curing livestock and poultry respiratory tract infections diseases and preparation method for traditional Chinese medicine |
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CN101112426A (en) * | 2007-08-06 | 2008-01-30 | 华云芳 | Chinese traditional medicine composition for preventing and treating avian infectious laryngotracheitis and method of making the same |
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CN102552417A (en) * | 2012-01-11 | 2012-07-11 | 河南天纳图生物科技有限公司 | Chinese medicine for bird respiratory diseases |
CN104383133A (en) * | 2014-10-23 | 2015-03-04 | 郑州后羿制药有限公司 | Traditional Chinese medicine curing livestock and poultry respiratory tract infections diseases and preparation method for traditional Chinese medicine |
CN106109831A (en) * | 2016-08-16 | 2016-11-16 | 陈艳 | A kind of veterinary drug that can improve immunity of livestock |
CN107669826A (en) * | 2017-10-24 | 2018-02-09 | 丹东瑞丰动物药业有限责任公司 | One kind treats more pathogen respiratory syndrome herbal medicines of chicken and preparation method thereof |
CN118045047A (en) * | 2024-01-30 | 2024-05-17 | 广州中冠动物药业有限公司 | Bufonis venenum granule prepared by superfine pulverizing technology |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451161, Henan, Zhengzhou, Zhengzhou air port, Xingang Avenue East Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
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Granted publication date: 20110615 Termination date: 20200826 |