CN110559415B

CN110559415B - Natural plant compound preparation for improving young bird breeding rate and preparation method and application thereof

Info

Publication number: CN110559415B
Application number: CN201910904429.6A
Authority: CN
Inventors: 何斌; 杨文海; 吴利军; 边巴次仁; 陈夏冰; 邵志勇; 冉志平; 陈洁; 金尔光; 周华; 刘志伟; 者永辉
Original assignee: Wuhan Academy of Agricultural Sciences
Current assignee: Wuhan Academy of Agricultural Sciences
Priority date: 2019-09-24
Filing date: 2019-09-24
Publication date: 2022-01-18
Anticipated expiration: 2039-09-24
Also published as: CN110559415A

Abstract

The invention relates to the technical field of natural plant compound preparations for livestock and poultry feeding, and particularly discloses a natural plant compound preparation for feeding, which can improve the immunity and disease resistance of young poultry and increase the breeding rate of the young poultry, and a preparation method and application thereof. The natural plant composition is prepared from caulis polygoni multiflori, golden cypress, honeysuckle, plantain herb, radix sophorae flavescentis, astragalus mongholicus, burdock, sweet wormwood, houttuynia cordata, Chinese yam, purslane, Chinese pulsatilla root, antifebrile dichroa, folium isatidis, malt, dried orange peel, betel nut, dried ginger and liquorice according to a certain proportion. The preparation prepared by the invention is mainly suitable for enhancing the immunity and disease resistance of young birds and effectively improving the breeding rate of the young birds, and the preparation has the advantages of simple method, easy implementation, environmental protection, safety, obvious effect and better economic and social benefits.

Description

Natural plant compound preparation for improving young bird breeding rate and preparation method and application thereof

Technical Field

The invention relates to the technical field of natural plant compound preparations for livestock and poultry feeding, in particular to a natural plant compound preparation for improving the immunity and disease resistance of young poultry and increasing the breeding rate of the young poultry, and a preparation method and application thereof.

Background

In recent years, with the continuous development of large-scale and intensive poultry breeding, various diseases are in diversified development, which causes the poultry to die in large scale and the production capacity to be reduced, and the production and development of the poultry industry are seriously influenced. In the process of preventing and treating the epidemic diseases of the poultry, antibacterial drugs, hormones and vaccines play a certain role, but the use of the antibacterial drugs, the hormones and the vaccines in large quantities causes high incidence of immunosuppression of the poultry, and the residue of chemical drugs and the emission in the environment bring serious harm to the safety of animal-derived foods and the ecological environment.

In the antibacterial drug use reduction action work in rural areas of agriculture, veterinarian authorities definitely require that chemical drug feed additives are completely withdrawn from a feed end in 2020, and antibacterial drugs, hormones and other chemical drugs are prohibited from being added into breeding feeds, so that poultry feeds are no exception. China science and technology personnel do a lot of work on the aspects of improving chicken immunity and promoting growth by Chinese herbal medicines, and in CN 102640864A 'Chinese herbal medicine feed additive for improving chicken immunity and preventing diarrhea and use method thereof', the Chinese herbal medicine feed additive is prepared by taking fleece-flower root, epimedium herb, radix codonopsitis, bighead atractylodes rhizome, tuckahoe, coptis root, phellodendron bark, scutellaria root, platycladi seed, jujube kernel, angelica, peony, costustoot, scorched medicated leaven, scorched malt, scorched hawthorn fruit, dragon bone, oyster, betel nut, cyrtomium rhizome and liquorice as raw materials, screening, drying, crushing, mixing and subpackaging. After feeding the chicken for two courses of treatment according to a certain proportion, the separation and counting of escherichia coli and salmonella in chicken intestinal tracts are reduced to a certain extent. In CN 106309464A, "a composition of Chinese medicinal ingredients for livestock and poultry immunization and antivirus, its preparation method and application", Scutellariae radix, radix Sophorae Flavescentis, flos Lonicerae, cortex Phellodendri or radix Berberidis or Coptidis rhizoma, radix Isatidis, Galla chinensis, rhizoma Ligustici Chuanxiong, radix et rhizoma Rhei, and herba Thymi, after extracting with water respectively or after mixing, it can be used in livestock and poultry raising process, can get rid of the use of antibiotic medicine, significantly improve chicken immune organ index, improve Newcastle disease antibody level, and has good treatment and prevention effects on chicken Newcastle disease virus, swine fever virus, etc. In CN 106822522A, "preparation method and application of Chinese medicinal fermentation preparation for improving growth performance and immunity of poultry", bupleuri radix, rhizoma Ligustici Chuanxiong, rhizoma Cyperi, pericarpium Citri Tangerinae, fructus Aurantii, radix Paeoniae, and Glycyrrhrizae radix are selected, and mixed with Bacillus coagulans, fermented, and directly added into poultry feed to significantly promote animal growth, improve immunity, regulate intestinal microbial balance, and have effects of relaxing bowels, relieving diarrhea, and promoting growth.

Aiming at the problems of single and insufficient functions in the prior art such as reduction of the number of escherichia coli and salmonella in chicken intestinal tracts, improvement of chicken immune organ indexes, promotion of animal growth, improvement of immunity, regulation of intestinal tract microbial balance and the like, the invention mainly analyzes the cause of diseases aiming at the dialectical angle of common diseases of young chickens, and adopts the dialectical treatment principle of strengthening healthy qi to eliminate pathogenic factors, tonifying qi to dredge collaterals, clearing heat and detoxicating, stopping dysentery and expelling parasites, and clearing damp and tonifying spleen to carry out medicine formula research and prevention and treatment of epidemic diseases aiming at the pathogenic factors; compared with the closest prior art, the invention comprehensively and effectively prevents and treats various epidemic diseases caused by bacteria, parasites and viruses in the process of raising the chicks, is obviously higher than the prior art in the aspects of enhancing the immunity of the chicks and promoting the development of immune organs of the chicks, and is also obviously better than the prior art in the aspect of preventing and treating effects aiming at various diseases.

Currently, the occurrence of poultry epidemic disease seriously restricts the forward development of the breeding industry, and huge economic loss is brought to the breeding industry every year. Due to unreasonable overuse of vaccines and abuse of chemical drugs such as antibiotics and hormones, the poultry, particularly young birds, have low immune function and even generate immunosuppression, and antibodies cannot be effectively generated to protect animal organisms after the vaccines are used; meanwhile, the epidemic disease of the poultry is more and more complicated, mixed infection of bacteria, viruses and parasitic diseases occurs, and the drug resistance of the bacteria is continuously increased; the occurrence of the phenomena seriously restricts the forward development of poultry breeding in our country. In view of the dilemma faced by the poultry industry at present and the defects of the existing traditional Chinese veterinary medicine in the application of young poultry, the invention selects a plurality of traditional Chinese herbal medicines according to the theory of traditional Chinese veterinary medicine and by combining the clinical practical use situation of veterinarians, and researches the prescription and the preparation from the aspects of strengthening body resistance and eliminating evil, tonifying qi and dredging collaterals, clearing away heat and toxic material, stopping dysentery and expelling parasites, and eliminating dampness and tonifying spleen, so that the aims of effectively solving the low immunity of the young poultry, preventing and treating the occurrence of bacterial, viral and parasitic diseases and further improving the breeding rate of the young poultry are achieved.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a compound natural plant preparation for enhancing the immunity and disease resistance of young birds and a preparation method and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a natural plant compound preparation for enhancing the immunity and disease resistance of young birds is prepared from the following medicinal materials in parts by weight:

2-15 parts of caulis polygoni multiflori, 0.1-10 parts of phellodendron amurense, 0.5-13 parts of honeysuckle, 0.1-10 parts of plantain herb, 0.1-5 parts of radix sophorae flavescentis, 0.5-20 parts of astragalus membranaceus, 0.2-15 parts of burdock, 0.1-20 parts of sweet wormwood herb, 0.5-13 parts of houttuynia cordata, 0.5-30 parts of Chinese yam, 0.5-20 parts of purslane, 0.5-20 parts of Chinese pulsatilla root, 0.2-13 parts of dichroa root, 0.5-13 parts of folium isatidis, 0.5-25 parts of malt, 0.5-23 parts of dried orange peel, 0.1-13 parts of betel nut, 0.3-10 parts of dried ginger and 0.5-20 parts of liquorice.

Further, 5-10 parts of caulis polygoni multiflori, 0.5-2 parts of phellodendron amurense, 1-3 parts of honeysuckle, 1-3 parts of plantain herb, 0.3-1.5 parts of radix sophorae flavescentis, 1-2 parts of astragalus membranaceus, 2-5 parts of burdock, 1-2 parts of sweet wormwood herb, 1-3 parts of houttuynia cordata, 1.5-3 parts of Chinese yam, 1.5-6 parts of purslane, 1.5-3 parts of Chinese pulsatilla root, 0.5-3 parts of antifebrile dichroa, 1-3 parts of folium isatidis, 1.5-5 parts of malt, 1-3 parts of dried orange peel, 1-3 parts of betel nut, 0.3-1 part of dried ginger and 0.6-3 parts of liquorice.

Preferably, the natural plant compound preparation is prepared from the following medicinal materials in parts by weight: 8 parts of caulis polygoni multiflori, 1.5 parts of phellodendron amurense, 2 parts of honeysuckle, 2 parts of plantain herb, 1 part of sophora flavescens, 2 parts of astragalus, 5 parts of burdock, 2 parts of sweet wormwood, 2 parts of houttuynia cordata, 2 parts of Chinese yam, 3 parts of purslane, 2 parts of Chinese pulsatilla root, 2 parts of antifebrile dichroa, 3 parts of folium isatidis, 5 parts of malt, 2 parts of dried orange peel, 1 part of betel nut, 0.5 part of dried ginger and 3 parts of liquorice.

The preparation method of the compound natural plant compound preparation comprises the following steps:

taking nineteen medicinal materials of caulis polygoni multiflori, phellodendron amurense, honeysuckle, plantain herb, sophora flavescens, astragalus, burdock, sweet wormwood, houttuynia, Chinese yam, purslane, Chinese pulsatilla root, antifebrile dichroa, folium isatidis, malt, dried orange peel, betel nut, dried ginger and liquorice, mixing, adding water with the temperature of 60-65 ℃ which is 10-14 times (preferably 12 times) of the total weight of the medicinal materials for soaking for more than 8 hours, then heating the mixture until the water boils and reflows for extracting for 8-15 hours, then concentrating the feed liquid to 2.5-3.5 times (preferably 3 times) of the total weight of the Chinese medicinal materials, standing for more than 10 hours, precipitating, taking supernatant for concentrating under reduced pressure, spray drying, collecting powder, crushing, sieving by a 50-mesh sieve, and uniformly mixing to obtain the Chinese medicinal composition. The obtained product selects 4 quality control indexes of astragalus polysaccharide, luteolin, arctigenin and indirubin, wherein the content of the astragalus polysaccharide in the extract is not less than 8.0 wt%, the content of the luteolin is not less than 0.05 wt%, the content of the arctigenin is not less than 3.0 wt%, and the content of the indirubin is not less than 0.02 wt%.

The invention aims at the defects of short intestinal tract and poor absorption of the Chinese herbal medicine dispersing agent of poultry, particularly chicks, and extracts the formula to form a water extract, thereby being convenient for breeding and use and also improving the curative effect and the utilization rate of the medicine.

The invention is guided by veterinary medicine theory in Chinese tradition, Chinese treasure Chinese herbal medicine characteristic and main problem of low young poultry breeding rate and poultry digestive system characteristic, and strict formula principles of monarch, minister, assistant and guide, seven-emotion compatibility and the like of the traditional Chinese medicine are adopted, so that the young poultry is clear in division of work and plays its own role; meanwhile, the compound preparation for improving the breeding rate of the young poultry is screened one by one in a large number of clinical application tests. The indications and efficacies of the medicaments of the invention are as follows: the caulis polygoni multiflori has the functions of nourishing yin, nourishing blood, dredging collaterals and soothing the nerves; the astragalus root has the effects of tonifying qi, strengthening exterior, strengthening heart and the like; honeysuckle flower has the effects of clearing away heat and toxic materials, tonifying deficiency and treating wind; the yam tonifies deficiency and wins, removes cold and heat evil, strengthens middle-jiao and Qi and strengthens yin; gan Jiang warms the middle-jiao to dispel cold, returns yang to activate collaterals, warms lung to resolve retained fluid. Cortex Phellodendri has effects in clearing away heat and toxic materials, purging pathogenic fire, eliminating dampness, and relieving deficiency heat; fructus Arctii has effects of dispelling pathogenic wind and heat, removing toxic substance, and dispersing lung qi; herba plantaginis has effects of clearing away heat and eliminating phlegm; the sophora flavescens has the functions of clearing heat and drying dampness, killing parasites and promoting urination, and the sophora flavescens and the phellodendron amurense have the effects of tonifying kidney and treating wind and killing parasites together; herba Artemisiae Annuae has effects of clearing heat, cooling blood, and relieving hectic fever due to yin deficiency; purslane has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery; the Chinese pulsatilla root has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery; folium Isatidis has effects of clearing away heat and toxic materials, cooling blood, and eliminating macula; chang shan plays the role of inducing vomiting of phlegm and saliva and checking malaria. The heartleaf houttuynia herb has the effects of clearing away heat and toxic materials, stopping dysentery, promoting urination, removing dampness, invigorating stomach and promoting digestion; the malt has the effects of promoting qi circulation to promote digestion, strengthening spleen and stimulating appetite; the dried orange peel can regulate qi, invigorate spleen, eliminate dampness and reduce phlegm; the betel nuts play a role in removing food retention; the liquorice has the effects of tonifying qi and spleen, regulating the middle warmer and relieving urgency and harmonizing the effects of the other medicines.

The compound preparation developed by the invention mainly plays the effects of strengthening body resistance and eliminating evil, tonifying qi and dredging collaterals, and is a monarch drug part; the golden cypress, the great burdock achene, the plantain herb, the lightyellow sophora root, the sweet wormwood herb, the purslane, the Chinese pulsatilla root, the indigowoad leaf and the antifebrile dichroa are mainly used for playing the efficacies of clearing away heat and toxic materials, cooling blood, stopping dysentery and expelling parasites and are used as ministerial medicine parts; the cordate houttuynia, the malt, the dried orange peel and the betel nut mainly play the auxiliary role of strengthening the spleen, promoting digestion and the like and are used as adjuvant medicines; the liquorice is mainly used for regulating the effects of the medicaments; the medicines are matched to have the effects of strengthening vital qi to eliminate pathogenic factors, tonifying qi to dredge collaterals, clearing heat and detoxicating, stopping dysentery and expelling parasites, and clearing damp and tonifying spleen; can effectively enhance the immunity and disease resistance of the young poultry, improve the growth speed of the young poultry and the feed conversion rate, and further improve the breeding rate of the young poultry.

Compared with the prior art, the invention has the advantages that:

1. under the large background of national resistance reduction and resistance substitution, the development and application of the natural plant formula preparation for feed effectively reduce the use of a large amount of traditional antibacterial drugs, and the application of the natural plant formula preparation for feed is a new method and an effective way for solving the problem of resistance reduction and resistance substitution in the current livestock and poultry breeding process;

2. the preparation product of the invention is composed of pure natural plants, is safe and efficient, does not relate to drug residues, and meets the current ecological, safe and green development requirements of poultry industry and the consumption requirements of people on safe animal-derived products;

3. the invention is a natural plant compound preparation extract, can be used by drinking water, is beneficial to the absorption and utilization of the digestive tract of poultry, and has obvious curative effect; strengthening body resistance to eliminate pathogenic factors, invigorating qi, dredging collaterals, clearing away heat and toxic materials, relieving dysentery, expelling intestinal parasites, eliminating dampness, and invigorating spleen; the immunity and disease resistance of the young poultry can be effectively enhanced, the growth speed of the young poultry and the feed conversion rate are improved, and the breeding rate of the young poultry is further improved;

4. the effect is obvious, and the breeding rate of the young poultry in the experiment is as high as 99.8%.

Detailed Description

In order that those skilled in the art may better understand and practice the present invention, the following detailed description is presented in conjunction with specific embodiments. The following should not be construed to limit the scope of the claims in any way.

Example 1

A feeding natural plant compound preparation for efficiently improving the immunity, disease resistance and breeding rate of young birds is prepared from the following medicinal materials in parts by weight:

5 parts of caulis polygoni multiflori, 0.5 part of phellodendron amurense, 1 part of honeysuckle, 1 part of plantain herb, 0.3 part of sophora flavescens, 1 part of astragalus, 2 parts of burdock, 1 part of sweet wormwood herb, 1 part of heartleaf houttuynia herb, 1.5 parts of Chinese yam, 1.5 parts of purslane, 1.5 parts of Chinese pulsatilla root, 0.5 part of antifebrile dichroa, 1 part of dyers woad leaf, 1.5 parts of malt, 1 part of dried orange peel, 1 part of betel nut, 0.3 part of dried ginger and 0.6 part of liquorice.

In this example, 100kg is taken as 1 part by weight.

The preparation method of the natural plant compound preparation comprises the following steps:

weighing the nineteen medicinal materials (all medicinal material decoction pieces) respectively, mixing, adding 62 ℃ water which is 12 times of the total weight of the nineteen medicinal materials, soaking for 10 hours, heating to boiling (100 ℃) for reflux extraction for 10 hours, then concentrating the feed liquid to 3 times of the total weight of the nineteen medicinal materials, standing for 12 hours, precipitating, taking supernate, concentrating under reduced pressure, spray-drying, collecting powder, crushing, sieving with a 50-mesh sieve, and uniformly mixing to obtain the medicinal material, wherein the final extraction rate is 25.3 wt% (the obtained powder accounts for the proportion of the total weight of the nineteen raw medicinal materials, and the method is the same as below and is not repeated). By detecting the quality control indexes, in the compound preparation prepared in the embodiment, the content of astragalus polysaccharide is 8.3 wt%, the content of luteolin is 0.053 wt%, the content of arctigenin is 3.9 wt%, and the content of indirubin is 0.024 wt%.

Example 2

8 parts of caulis polygoni multiflori, 1.5 parts of phellodendron amurense, 2 parts of honeysuckle, 2 parts of plantain herb, 1 part of sophora flavescens, 2 parts of astragalus, 5 parts of burdock, 2 parts of sweet wormwood, 2 parts of houttuynia cordata, 2 parts of Chinese yam, 3 parts of purslane, 2 parts of Chinese pulsatilla root, 2 parts of antifebrile dichroa, 3 parts of folium isatidis, 5 parts of malt, 2 parts of dried orange peel, 1 part of betel nut, 0.5 part of dried ginger and 3 parts of liquorice.

In this example, 150kg was calculated as 1 part by weight.

The preparation was prepared according to the preparation method of example 1, and the final extraction rate was 26.1 wt%. The quality control indexes are detected, and in the compound preparation prepared in the embodiment, the content of astragalus polysaccharide is 8.4 wt%, the content of luteolin is 0.056 wt%, the content of arctigenin is 3.5 wt%, and the content of indirubin is 0.022 wt%.

Example 3

10 parts of caulis polygoni multiflori, 2 parts of phellodendron amurense, 3 parts of honeysuckle, 3 parts of plantain herb, 1.5 parts of sophora flavescens, 2 parts of astragalus membranaceus, 5 parts of burdock, 2 parts of sweet wormwood, 3 parts of houttuynia cordata, 3 parts of Chinese yam, 6 parts of purslane, 3 parts of Chinese pulsatilla root, 3 parts of antifebrile dichroa, 3 parts of folium isatidis, 5 parts of malt, 3 parts of dried orange peel, 3 parts of betel nut, 1 part of dried ginger and 3 parts of liquorice.

In this example, 100kg is taken as 1 part by weight.

The preparation was prepared according to the preparation method of example 1, and the final extraction rate was 25.6 wt%. The quality control indexes are detected, and in the compound preparation prepared in the embodiment, the content of astragalus polysaccharide is 8.6 wt%, the content of luteolin is 0.053 wt%, the content of arctigenin is 3.6 wt%, and the content of indirubin is 0.025 wt%.

The compound preparations obtained in examples 1-3 were tested and verified as follows:

1. effect of the Compound preparations of the examples on the phagocytic function of mouse macrophages

In order to verify the influence of the compound preparation on the action of immunity, 40 mice to be tested are selected, each mouse weighs 22.0 +/-3.0 g and is provided by the experimental animal center of university of science and technology in Huazhong. 40 mice were divided into 4 groups of 10 mice each. 1. 2 and 3 groups are respectively irrigated with 0.1 g/one preparation in the examples 1, 2 and 3 every day, and 4 groups are blank control groups and are irrigated with starch suspension every day. After 1 week of continuous administration, 1.0mL of peptone with a mass fraction of 1.0% was intraperitoneally injected into mice, respectively; respectively injecting 0.5mL of pig red blood cell suspension with the mass fraction of 5% after 2 h; after 10h, the cervical vertebrae were removed and the white mouse was sacrificed, fixed in the mouse plate in the supine position, and 2.0mL of Ashi solution was injected into the abdominal cavity. Fully rotating the fixing plate, then extracting the macrophage lotion in the abdominal cavity, centrifuging, removing supernatant and smear, fixing, dyeing, drying and performing microscopic examination.

The number of macrophages per tablet is counted under an oil lens, and then the phagocytosis index and the phagocytosis rate are calculated. Phagocytosis (%) — (macrophages that phagocytose porcine red blood cells) × 100%; phagocytosis index is the total number of phagocytosed porcine red blood cells per 200 macrophages. The observed data for each group of mice were collated and the results are shown in the following table:

influence of compound preparation on phagocytic function of macrophage of white mouse

From the above table of experimental data, it can be found that the compound preparations of examples 1, 2 and 3 have strong influence on the phagocytic function of macrophages, wherein example 2 has the strongest promoting effect on the phagocytic function of macrophages; the compound preparations in examples 1, 2 and 3 have remarkably stronger macrophage phagocytic function promoting effect than that of a blank control group, which shows that the compound preparations have larger immunity improving effect, and example 2 has strongest immunity improving effect.

2. The influence of the compound preparation of each embodiment on the immune organ index and the antibody level of the chicken

80 chicks were randomly divided into 4 groups, and the average body weight difference was not significant among the groups. 20 of each group were administered with the compound preparations prepared in examples 1, 2 and 3 in the beginning of 14 days (200g/1000L, 200g of the drug was added to 1000L of water, and water was freely drunk every day until the end of the test on day 49), and group 4 was a control group with free water; the vaccine was immunized according to the normal procedure for each group. Collecting immune organs, feeding the chicks to 21 days and 35 days, randomly extracting 5 chickens from each group, and cutting off bursa of fabricius and weighing spleen; on the 49 th day, 10 chicken blood samples were collected for antibody level detection of bursa of fabricius, newcastle disease and avian influenza, and then 5 bursa of fabricius and spleen were dissected and killed and weighed. Calculation formula of immune organ index: immune organ index is immune organ weight/body weight. The difference is obvious when the test data is subjected to one-factor variance analysis, and the difference is extremely obvious when P is less than 0.05 and P is less than 0.01.

Effect of the Compound preparation of each example on the bursal disease index of chicks

Effect of the Compound preparations of the examples on the spleen index of chicks

As can be seen from the data, at 21-49 days of age, the groups 1-3 had significant average differences from the groups 4 in the bursal index and spleen index; the results show that the groups of the invention in examples 1-3 can obviously improve the immune organ index of the chicks, have obvious immune activity, and the example 2 is superior to the examples 1 and 3.

Effect of the Compound formulations of the examples on the antibody levels in chicks

The data show that the antibody levels of the chicken bursa of Fabricius, newcastle disease and avian influenza in the examples 1 to 3 of the invention are obviously superior to those of the control group, and the antibody levels have obvious improvement effect on the antibody levels of the chicken vaccine after immunization.

3. The compound preparation of each embodiment has the effect of treating the clinical diseases of the chicks

Experiment 1

5000 Tibetan chicks of 1 day old purchased by a certain farmer, part of chicks are diseased at the 4 th day, the infection of salmonella gallinarum is diagnosed, the chicks are divided into 5 groups, each group comprises 1000 chicks, and the 1 st group to the 3 rd group are respectively added with the compound preparation prepared in the embodiment 1 to 3 in drinking water according to the proportion of 200g/1000L of water every day, and the chicks are freely drunk; florfenicol is added into the drinking water of the 4 th group, the dosage is calculated by 200mg/kg of body weight every day, and the drinking water is freely drunk; group 5 served as a control group and no drug was added to the drinking water. Continuously feeding for 45 days, and observing and recording the overall morbidity change and the breeding rate of the test chicken group. The results are as follows:

note: the term "number of diseased chickens" includes "number of dead chickens".

As a result, it was found that: the death and morbidity of the chicken groups in the examples 1 to 3 are obviously lower than those of the florfenicol group and the control group, the number and the breeding rate of healthy chickens are obviously higher than those of the florfenicol group and the control group, and the breeding rate of the example 2 group is as high as 99.8%. The embodiment of the invention effectively reduces the morbidity and mortality of salmonella in brooding chicken groups and obviously enhances the disease resistance of chicks.

Experiment 2

1500 chicks are raised on the ground of a certain farmer, part of chicks are diluted when the chicks are 18 days old, a small amount of excrement is brown, and the initial diagnosis is chicken coccidiosis. Selecting 1000 drinking water to add the compound preparation prepared in the example 2(200g/1000L), adding 1mg of diclazuril into every 1L of water by using 400 diclazuril groups, freely drinking water all day, continuously feeding for 7 days, and then normally feeding; 100 were control groups, drinking water freely throughout the day. The clinical symptoms of example 2 and the diclazuril group were relieved after 4 days of drug treatment, and the specific test cases after the end of 45 days brooding are as follows:

The results show that the compound preparation 3 has a good clinical treatment effect on chicken coccidiosis, the cure rate reaches 97.2%, and compared with a diclazuril treatment group, the compound preparation obviously reduces the mortality and the morbidity of sick chickens and improves the disease resistance of chicken flocks.

Claims

1. The natural plant compound preparation for improving the breeding rate of young poultry is characterized by being prepared from the following medicinal materials in parts by weight: 5-10 parts of caulis polygoni multiflori, 0.5-2 parts of phellodendron amurense, 1-3 parts of honeysuckle, 1-3 parts of plantain herb, 0.3-1.5 parts of radix sophorae flavescentis, 1-2 parts of astragalus membranaceus, 2-5 parts of burdock, 1-2 parts of sweet wormwood herb, 1-3 parts of houttuynia cordata, 1.5-3 parts of Chinese yam, 1.5-6 parts of purslane, 1.5-3 parts of Chinese pulsatilla root, 0.5-3 parts of antifebrile dichroa, 1-3 parts of folium isatidis, 1.5-5 parts of malt, 1-3 parts of dried orange peel, 1-3 parts of betel nut, 0.3-1 part of dried ginger and 0.6-3 parts of liquorice;

the preparation method of the natural plant compound preparation comprises the following steps: mixing the medicinal materials in parts by weight, adding water with the temperature of 60-65 ℃ which is 10-14 times of the total weight of each medicinal material, soaking for more than 8 hours, heating until the water is boiled, refluxing and extracting for 8-15 hours, concentrating the feed liquid to 2.5-3.5 times of the total weight of each Chinese medicinal material, standing for more than 10 hours, precipitating, taking supernatant, concentrating under reduced pressure, spray drying, collecting powder, crushing, sieving with a 50-mesh sieve, and uniformly mixing to obtain the natural plant compound preparation.

2. The natural plant compound preparation as claimed in claim 1, which is prepared from the following medicinal materials in parts by weight: 8 parts of caulis polygoni multiflori, 1.5 parts of phellodendron amurense, 2 parts of honeysuckle, 2 parts of plantain herb, 1 part of sophora flavescens, 2 parts of astragalus, 5 parts of burdock, 2 parts of sweet wormwood, 2 parts of houttuynia cordata, 2 parts of Chinese yam, 3 parts of purslane, 2 parts of Chinese pulsatilla root, 2 parts of antifebrile dichroa, 3 parts of folium isatidis, 5 parts of malt, 2 parts of dried orange peel, 1 part of betel nut, 0.5 part of dried ginger and 3 parts of liquorice.

3. Use of the natural plant compound preparation of any one of claims 1-2 in preparing a medicament for enhancing immunity and disease resistance of young birds.