CN101940628B - Traditional Chinese medicinal compound medicine for treating livestock and poultry excessive heat syndrome - Google Patents
Traditional Chinese medicinal compound medicine for treating livestock and poultry excessive heat syndrome Download PDFInfo
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- CN101940628B CN101940628B CN2010102554761A CN201010255476A CN101940628B CN 101940628 B CN101940628 B CN 101940628B CN 2010102554761 A CN2010102554761 A CN 2010102554761A CN 201010255476 A CN201010255476 A CN 201010255476A CN 101940628 B CN101940628 B CN 101940628B
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Abstract
The invention discloses a traditional Chinese medicinal compound medicine capable of treating livestock or poultry excessive heat syndrome. The compound medicine comprises the following components in part by weight: 100 to 120 parts of honeysuckle, 120 to 140 parts of gypsum, 100 to 120 parts of rhubarb, 100 to 120 parts of red paeony root, 60 to 70 parts of weeping forsythiae, 100 to 120 parts of ephedra herb, 80 to 90 parts of astragalus, 80 to 90 parts of indigowoad root and 60 to 70 parts of liquorice. During use, the nine medicaments are crushed, screened and uniformly mixed to directly feed livestock and poultry, and also can be leached or decocted with water so as to extract active ingredients of the nine medicaments for feeding the livestock and poultry.
Description
Technical field
The present invention relates to a kind of that form by Chinese medicine, can treat the poultry or the medicine of fowl excess-heat syndrome.
Background technology
Excess-heat disease can be caused by reasons such as affection due to external wind and heat, epidemic disease, wind and cold, rheumatism, the clinical manifestation heating, and breathing is urged, and feces is done or damp and hot impairing the spleen and stomach, and body fluid can not be changed life, and instead for wet, damp invasion of lower energizer becomes to let out symptoms such as dysentery to water.Modern medicine study is thought heating mainly by antibacterial, and like escherichia coli, Salmonella, staphylococcus, pasteurellosis bacillus, bacillus pyocyaneus etc., mycoplasma, and virus etc. causes.
China is a poultry big country.According to estimates, the poultry mortality that China every year causes because of all kinds of fowl diseasess is up to 15～20%, and economic loss reaches billions of units.In whole fowl poultry kind disease, infectious disease accounts for 80%, and common disease accounts for 20%.And the kind of morbidity poultry also is on the increase, and the sick kind of poultry is complicated, and new disease constantly occurs, and since the eighties, common with poultry infectious disease disease, it is widely current, the serious harm livestock and poultry breeding industry.
At present, the sick common drug of treatment poultry infectious disease is to use antibiotic.Yet there is problems such as producing drug resistance, drug residue in long-term a large amount of antibiotic that use.
Chinese medicine derives from animal, plant and mineral, contains multiple biological effective components, and wherein most of Chinese medicines are to be raw material with the natural plants, aboundresources; Obtain easily, respond well, cheap, toxic and side effects is small; Almost noresidue, no Drug resistance, free from environmental pollution.Therefore, select for use Chinese medicine preparation to substitute antibiotic and seem particularly important.
Chinese invention patent application 200710301259.X discloses a kind of plant amedica compositions, its preparation of preventing and treating tame brutish infectious disease; It is made up of Radix Bupleuri, Rhizoma Atractylodis, the Radix Astragali, Radix Isatidis, windproof, Herba Portulacae, Radix Salviae Miltiorrhizae, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Houttuyniae, Rhizoma Osmundae, Radix Glycyrrhizae and Gypsum Fibrosum; The preferred water extract that uses above-mentioned raw materials is pointed out preparation commonly used separately according to conventional method.It is introduced that this pharmaceutical composition has heat-clearing and toxic substances removing, the effect of cooling blood for hemostasis can be used for infectious disease, toxic-heat and blood stasis prevention and the treatment of beastly birds, can be used for substituting antibiotics.
Chinese invention patent 200610012907.5 discloses the medicine of planting the control infectious bursal disease.It is formed by the assembly by a certain percentage of following Chinese medicine: Radix Isatidis, Folium Isatidis, Herba Taraxaci, Herba Andrographis, Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Cortex Phellodendri, Gypsum Fibrosum, the Rhizoma Anemarrhenae, the Radix Rehmanniae, the Radix Astragali, Radix Scrophulariae, Herba Agrimoniae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Glycyrrhizae; Can said medicine be pulverized in the use, levigate, mix to mix thoroughly and get final product; Adopt boiling water to soak during clinical practice 30-60 minute, the medicine active ingredient is fully dissolved separate out, help interior absorption of body of disease chicken; Add a little sugar and Vc simultaneously and make the auxiliary therapy medicine, can further improve drug effect.This clinical drug cure rate is higher, has no adverse reaction drug residue free and Drug resistance hidden danger.
Summary of the invention
The present invention provides a kind of and constitutes with Chinese medicine composition, can be used for treating the compound medicine of poultry excess-heat disease.
Compound medicine of the present invention consists of: Flos Lonicerae 110 ± 10 weight portions, Gypsum Fibrosum 130 ± 10 weight portions, Radix Et Rhizoma Rhei 110 ± 10 weight portions; Radix Paeoniae Rubra 110 ± 10 weight portions; Fructus Forsythiae 65 ± 5 weight portions, Herba Ephedrae 110 ± 10 weight portions, the Radix Astragali 85 ± 5 weight portions; Radix Isatidis 85 ± 5 weight portions, Radix Glycyrrhizae 65 ± 5 weight portions.Can above 9 herbal medicines be pulverized during concrete the use, sieve, directly supply the poultry feeding behind the mixing, but also reuse water extraction or decoct and extract its active ingredient to the poultry feeding.
Medicine of the present invention is using the Flos Lonicerae heat-clearing and toxic substances removing, Gypsum Fibrosum hot sweet Great Cold, and clear eliminating the pathogens from the lung stomach and heat clearing away and restlessness relieving, promoting the production of body fluid to quench thirst is monarch drug; Radix Et Rhizoma Rhei, eliminating heat pathogen by purging the bowels, Radix Paeoniae Rubra removing heat from blood and battalion are minister, and Herba Ephedrae, Fructus Forsythiae, the Radix Astragali attach inducing sweat and so on clearing away heat and expelling pathogen in the exterior, tonifying Qi and lifting yang, and diaphoresis, voiding the urinary bladder, share is assistant; Herba Ephedrae has depressed lung-energy dispersing concurrently, regulating fluid apssage; Radix Astragali invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription are messenger drug.All medicines share, can heat-clearing and toxic substances removing, and heat radiation is induced sweat, clearing away heat and cooling blood, the pestilence pathogenic heat of removing summer-heat the four stages in the course of an epidemic febrile disease can be captured broken knot again, cleanses the gastrointestinal excess-heat and stagnates.
The present invention adopts: diaphoretic therapy short " heat " sheds from body surface; Lung qi dispersing method short " heat " is sent from lung qi; Removing heat from blood method short " heat " appears from nutrient blood; Purgative therapy short " heat " is discharged from the intestines and stomach.Prescription is fully theoretical with reference to Chinese veterinarian's eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs, giving consideration to both the exterior and interior, and QI and blood is ruled together; Special with YAOJING, compatibility is careful and precise, has embodied " prevention of diseae " again; The prevention thought of " preventing exacerbation after being taken ill "; Embodied medication as using military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
Experiment through relevant shows that the present invention has heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors; The blood circulation promoting and blood stasis dispelling function, fire that can the clearing heat in QI system branch, heat that again can the removing heat from blood branch; Has good antipyretic and antidote functions; And medicine of the present invention is nontoxic, is applicable to pestilence pyretic toxicity and the card that all are burning hot, can be used for sick prevention of poultry infectious disease and treatment.
The specific embodiment
Be to use Flos Lonicerae 11Kg in the specific embodiment of the present invention, Gypsum Fibrosum 13Kg, Radix Et Rhizoma Rhei 11Kg, Radix Paeoniae Rubra 11Kg, Fructus Forsythiae 6.5Kg, Herba Ephedrae 11Kg, Radix Astragali 8.5Kg, Radix Isatidis 8.5Kg, Radix Glycyrrhizae 6.5Kg
Accurately take by weighing each medicine in last several ratios,, cross 60 mesh sieves, mixing through drying and crushing.Packing is subsequent use.
In order to observe sphere of action and the antibiotic pedigree of the present invention to the poultry infectious disease, prescription of the present invention has been carried out extracorporeal bacteria inhibitor test, be intended to confirm the antibacterial efficacy of this preparation, for further inquiring into clinical treatment disease scope theoretical foundation is provided.So adopt the solid medium dilution method, 8 kinds of antibacterials carried out extracorporeal bacteria inhibitor test.The result shows that decoct of the present invention, preserved material have bacteriostasis to ETEC, Pullorum Disease Salmonella, fowl cholera pasteurellosis bacillus, pig lung plague pasteurellosis bacillus etc. behind high pressure, and its antibacterial least concentration is 1: 180.Decoct of the present invention, preserved material, powder have good bacteriostasis without high pressure to ETEC, Pullorum Disease Salmonella, fowl cholera pasteurellosis bacillus, pig lung plague pasteurellosis bacillus; Wherein best with the powder bacteriostasis; To above antibacterial, minimum inhibitory concentration is more than 1: 720.And powder also has bacteriostasis preferably to decoct, preserved material (behind the high pressure and not high pressure) relatively poor staphylococcus aureus, bacillus pyocyaneus, the bacillus rhusiopathiae suis of fungistatic effect, and its minimum inhibitory concentration reaches 1: 180.
Experimentation shows; The present invention has obvious therapeutic action to the rabbit syndrome in QI system of endotoxin induced; Can obviously suppress heating (on average reducing by 1 ℃ of temperature), improve hemogram and change, the whole blood contrast viscosity of laboratory animal obviously reduces with the ratio of reduction whole blood contrast viscosity; And significantly shorten erythrocyte electrophoretic time, but packed cell volume and erythrocyte sedimentation rate there is not obvious influence.Reduce mortality rate, prolong the time-to-live; PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM shows, the effect that the present invention has the protection internal organs, alleviates pathological lesion.
The present invention adopts the random double blind test method to carry out the therapeutic test of chicken lung-heat (infectious laryngotracheitis), chicken colibacillosis and the swine escherichia coli of various dose treatment natural occurrence and artificial challenge's morbidity, and selects the positive medicine matched group of florfenicol for use.Observe the present invention to chicken lung-heat (infectious laryngotracheitis), chicken colibacillosis and swine escherichia coli therapeutical effect, to inquire into its Application feasibility in Production of Livestock and Poultry.
The present invention is in artificial infection chicken's lung-heat (infectious laryngotracheitis) test; Has excellent curative; High, in two dose groups to the cure rate of lung-heat (infectious bronchitis) be 76.6%, effective percentage is 96.7%; Its curative effect and florfenicol are suitable, compare difference extremely significantly (P＜0.01) with the infection matched group.
The present invention is in the therapeutic test of artificial challenge's colibacillosis of pigs, and the cure rate of low dose group is 67.8%, and total effective rate is 84.5%; High, in two dose groups be 78% to the cure rate of colibacillosis of pigs, total effective rate is 91%, mortality rate is merely 9%, and is poorer slightly than florfenicol treatment group; Compare difference extremely significantly (P＜0.01) with the infection matched group.
To the treatment of natural occurrence colibacillosis of pigs, high, middle dosage treatment group cure rate is 79.0%, and mortality rate, aggregate efficiency are 11%, 89.0% respectively.The high, medium and low dosage of the present invention all has therapeutical effect to colibacillosis of pigs, can relief of symptoms, reduce mortality rate, and high, middle dosage reducing mortality rate, and the effect that improves aspect such as cure rate and florfenicol is suitable.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences on 0.05 level, so dosage, so not only economic curative effect but also remarkable in can adopting during clinical use.
The present invention is in the chicken colibacillosis therapeutic test.Artificial vaccination escherichia coli (O
78) strong toadstool kind 5h after, except that blank, chicken begins to occur onset state, shows as lassitude, flocks together, necking down, and row's HUANGBAI(sic) loose stool phenomenon is arranged.And behind the treatment group medicine feed 24h, the spirit of drug group chicken is better than positive controls, but not as negative control group; Add up death toll behind the 36h, the drug group chicken is obviously lacked than the positive controls death toll; Observe behind the 48h, the drug group chicken no longer includes dead the generation, and improvement in various degree appears in each group, and positive controls still has dead successively the generation.Behind the 3d, spirit, the appetite of drug group chicken takes a favorable turn (increase from feeding capacity and find out), and feces is normal; The state of an illness of positive controls is more and more heavier, continues to take place dead.See that from therapeutic effect the cure rate of low dose group of the present invention is 67.0%, total effective rate is 83.5%; Two groups of high dose group and middle dose groups can reach the curative effect more than 71%; Total effective rate reaches 87.5%; Cure rate and florfenicol treatment group do not have significant difference (P＞0.05), and effective percentage is poorer slightly than florfenicol treatment group, compare difference extremely significantly (P＜0.01) with the infection matched group.
To the treatment of natural occurrence chicken colibacillosis, high, middle dosage is to the effect suitable (total effective rate is all 88.0%) of therapeutic effect and florfenicol.The therapeutic effect of low dose group (total effective rate is 83.6%) is lower than height, middle dose groups, and middle and high dose groups is not all having significant difference aspect mortality rate, cure rate and the total effective rate; 5 days therapeutic effect of high, middle dose groups all is significantly higher than 3 days therapeutic effect.
From result of the test, the present invention has heat-clearing and toxic substances removing, dehumidifying dysentery relieving, strengthening vital QI to eliminate pathogenic factors, functions such as blood circulation promoting and blood stasis dispelling.Do not find that in the clinical trial process this medicine has untoward reaction.High, medium and low dosage has better therapeutic effect to chicken lung-heat (infectious laryngotracheitis), colibacillosis of pigs and chicken colibacillosis, and high, middle dosage is suitable to the effect of therapeutic effect and florfenicol.The therapeutic effect of low dose group is lower than height, middle dose groups, middle and high dose groups there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to the weight and treatment cost of the state of an illness, the suggestion clinical practice is with middle dosage (horse, cattle 150～250g; Sheep, pig 30～50g; Rabbit, fowl 1～2g every day, logotype 3～5 days; Or mix and to raise, every 1kg feedstuff 10～20g) is for well, logotype 3～5 days.
For clear and definite novel anti-infection herbal medicine compound preparation toxic and side effects of the present invention, in the hope of its safety is made accurately, objective appraisal, for the clinical trial medication provides scientific basis, guarantee clinical drug safety, carried out toxicity test of the present invention.
Through mice is carried out LD of the present invention
50Show that with mtd test after design dosage oral administration, it is normal respectively to organize mice behavior sign in 7 days, poisoning symptom and death all do not occur.So can't measure LD
50, and have to be maximum dose level with maximum dosage-feeding 80g/kg.After slaughtering in the 8th day, each organizes the mice internal organs does not all have pathological changes, and pathological characters is not found in the liver,kidney,spleen histological examination yet.Hemogram and serum GPT are active to detect result and normal mouse there was no significant difference.
Use Chinese herb compound the present invention to produce the toxicity and the order of severity in order to grasp because of continuous, and development after the drug withdrawal and recovery situation, for drafting data for clinical drug use dosage reference is provided.On mice, carried out subacute toxicity test of the present invention, in experimental period, except that high dose group is ingested because of drug dose causes the palatability difference to influence greatly; All the other respectively organize the mice diet, behavior, and feces is all normal; Physically well develop; Do not have any poisoning symptom, weightening finish and nutrition except that high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. all do not have obvious poisoning pathological changes.By the 3-10 of the clinical application amount 30d that doubly feeds, do not see toxic and side effects yet, the clinical medicine dose that said preparation is described is very safe.
Medicine of the present invention is according to the listing terms of packing, and in temperature: 40 ℃ ± 2 ℃, relative humidity: accelerated tests is 3 months under 75% ± 5% condition, and quality does not have significant change.In temperature: 25 ℃ ± 2 ℃ relative humiditys: long term test is 24 months under 60% ± 10% condition, and quality does not have significant change.Above-mentioned result of the test shows that medicine of the present invention storage quality under rated condition is stable.
Claims (1)
1. the traditional Chinese compound medicine of treatment poultry excess-heat syndrome is characterized in that compound medicine consists of: Flos Lonicerae 110 ± 10 weight portions, Gypsum Fibrosum 130 ± 10 weight portions; Radix Et Rhizoma Rhei 110 ± 10 weight portions, Radix Paeoniae Rubra 110 ± 10 weight portions, Fructus Forsythiae 65 ± 5 weight portions; Herba Ephedrae 110 ± 10 weight portions; The Radix Astragali 85 ± 5 weight portions, Radix Isatidis 85 ± 5 weight portions, Radix Glycyrrhizae 65 ± 5 weight portions.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102554761A CN101940628B (en) | 2010-08-14 | 2010-08-14 | Traditional Chinese medicinal compound medicine for treating livestock and poultry excessive heat syndrome |
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| CN2010102554761A CN101940628B (en) | 2010-08-14 | 2010-08-14 | Traditional Chinese medicinal compound medicine for treating livestock and poultry excessive heat syndrome |
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| CN101940628A CN101940628A (en) | 2011-01-12 |
| CN101940628B true CN101940628B (en) | 2012-05-23 |
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| CN102579622B (en) * | 2012-03-03 | 2014-06-25 | 贵州省畜牧兽医研究所 | Chinese herbal preparation for treating haemophilusparasuis and preparation method thereof |
| CN102960565B (en) * | 2012-11-28 | 2014-07-09 | 江汉大学 | Natural plant chicken heat stress resistant feed addictive and preparation method thereof |
| CN103536668B (en) * | 2013-11-08 | 2015-09-30 | 四川巴尔农牧集团有限公司 | The preparation method of dysentery relieving Chinese medicine composition |
| CN103536667B (en) * | 2013-11-08 | 2015-11-04 | 四川巴尔农牧集团有限公司 | Dysentery relieving Chinese medicine composition |
| CN107334867A (en) * | 2017-06-12 | 2017-11-10 | 河南中盛动物药业有限公司 | A kind of animal KANGKAN KELI and preparation method thereof |
Citations (2)
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| CN1483463A (en) * | 2003-07-01 | 2004-03-24 | 河北以岭医药研究院有限公司 | Anti-virus Chinese medicine composition and preparation process thereof |
| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicine for preventing and treating infectious bronchitis of chicken |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1483463A (en) * | 2003-07-01 | 2004-03-24 | 河北以岭医药研究院有限公司 | Anti-virus Chinese medicine composition and preparation process thereof |
| CN101181496A (en) * | 2007-11-16 | 2008-05-21 | 河北农业大学 | Medicine for preventing and treating infectious bronchitis of chicken |
Non-Patent Citations (1)
| Title |
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| 孙福星.白虎汤加味治愈猪"无名高热".《中兽医医药杂志》.1986,(第1期),47-48. |
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