CN103550314A - Veterinary medicine for treating colibacillosis and white diarrhea - Google Patents
Veterinary medicine for treating colibacillosis and white diarrhea Download PDFInfo
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- CN103550314A CN103550314A CN201310545394.4A CN201310545394A CN103550314A CN 103550314 A CN103550314 A CN 103550314A CN 201310545394 A CN201310545394 A CN 201310545394A CN 103550314 A CN103550314 A CN 103550314A
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Abstract
The invention relates to a veterinary medicine, especially relates to a medicine formed by combining natural plants with natural minerals, more specifically relates to the veterinary medicine for preventing and treating colibacillosis and/or white diarrhea, and in particular relates to the medicine for treating the colibacillosis and/or the white diarrhea of poultry. The medicine is prepared from honeysuckle, gypsum, root of common peony, anemone chinensis, fructus forsythiae, cyrtomium fortunei, radix sophorae flavescentis, radix lsatidis and licorice root.
Description
Technical field
The present invention relates to a kind of veterinary drug, the medicine that particularly a kind of use natural plants and natural minerals prescription form, a kind of for preventing and treat the veterinary drug of colibacillosis and/or Hakuri more exactly, especially for the treatment colibacillosis of birds and/or the medicine of Hakuri.
Background technology
China Shi Yige poultry big country.According to estimates, the poultry mortality that China causes because of all kinds of fowl diseasess is every year up to 15 ~ 20%, and economic loss reaches billions of units.In whole poultry disease, infectious disease accounts for 80%, and common disease accounts for 20%.And the kind of morbidity fowl is also on the increase, and fowl diseases kind is complicated, new sick continuous appearance, since the eighties, sick common with chicken colibacillosis, Pullorum Disease etc., it is widely current, serious harm poultry cultivation.Pullorum Disease is by the salmonellal a kind of infectious disease of Pullorum Disease, and young bird is acute sepsis process after infecting more, and M & M is high.Adult Chicken infection is chronic or recessive more carries disease germs, can be through feces discharge of bacteria, and contaminated environment, disseminates cause of disease.Because Adult Hen ovary carries disease germs, and can vertical transmission, have a strong impact on incubation rate and survivability of chicks.Chickling is high at temperature, high humidity and feeding and management be poor in the situation that, normal break out and spread, and mortality rate is up to more than 80%, the resistance to chicken poor growth of crossing, resistance reduces, and to poultry husbandry, causes great economic loss.
Chicken colibacillosis is a kind of infectious disease being caused by escherichia coli, and this disease can cause the chicken morbidity of different days and kind.Clinically, take and arrange yellow-white loose stool, septicemia, perihepatitis, airsacculitis and pericarditis as principal character.This disease is normal and other diseases is concurrent or secondary, very serious to poultry husbandry harm.Because colibacillary serotype is very many, use vaccine immunization effect undesirable, so becoming, Drug therapy controls this sick Main Means.
At present, the common method for the treatment of Pullorum Disease and/or colibacillosis is the long-term antibiotic that adds in feedstuff.Yet there is problems such as producing drug resistance, drug residue in long-term a large amount of antibiotic that use in feedstuff.
Summary of the invention
The invention provides and a kind ofly overcome existing antibiolics deposits yields drug resistance, and medicine residual problem in animal body after using, the veterinary drug for the treatment of escherichia coli and/or Hakuri.
Pharmaceutical formulation of the present invention is:
Flos Lonicerae 110 ± 5% weight portion Gypsum Fibrosum 130 ± 5% weight portions
Radix Paeoniae Rubra 110 ± 5% weight portion Radix Pulsatillae 110 ± 5% weight portions
Fructus Forsythiae 65 ± 3% weight portion Rhizoma Osmundae 65 ± 3% weight portions
Radix Sophorae Flavescentis 65 ± 3% weight portion Radix Isatidis 85 ± 5% weight portions
Radix Glycyrrhizae 65 ± 3% weight portions.
The present invention's its day amount when the chicken is 2g/ every day, generally can be used in conjunction 3 ~ 5 days, can or mixed feeding.The every lkg feedstuff of ordinary circumstance adds 10 ~ 20g, is used in conjunction 3 ~ 5 days.Appetite when the present invention is used for preventing is chicken 1g/ every day, is used in conjunction 3 days, and once, chicken reduces by half later every 3 months clothes.
The preparation of medicine of the present invention be by above 11 taste medicines through pulverizing, sieve, mixing, can clinical use.Through corresponding clinical trial certificate the present invention, there is heat-clearing and toxic substances removing, dehumidifying dysentery relieving, strengthening vital QI to eliminate pathogenic factors, both the colibacillosis of available dry birds and Pullorum Disease prevention and treatment, also can be used for livestock like the control of disease.
In Chinese veterinarian's theory, the clinical symptoms that Pullorum Disease and chicken colibacillosis occur belongs to excess-heat syndrome or dysentery with red and white feces, controls suitable heat-clearing and toxic substances removing, dehumidifying dysentery relieving, strengthening vital QI to eliminate pathogenic factors.
Medicine of the present invention is to use Flos Lonicerae, Gypsum Fibrosum, Radix Paeoniae Rubra, Radix Pulsatillae heat-clearing and toxic substances removing, removing heat from blood and battalion, and promoting the production of body fluid to quench thirst, dysentery relieving is monarch drug; Herba Ephedrae, Fructus Forsythiae, astragalus, Radix Isatidis are accompanied by the clearing away heat and expelling pathogen in the exterior that induces sweat and so on, tonifying Qi and lifting yang, and diaphoresis, voiding the urinary bladder, is ministerial drug as if remove Chen Quan; Rhizoma Osmundae, Radix Sophorae Flavescentis heat-clearing and toxic substances removing develop simultaneously, worm dysentery relieving share as assistant; Herba Ephedrae has depressed lung-energy dispersing concurrently, and regulating fluid apssage is intended to " carry kettle and take off lid ".Astragalus invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.All medicines share, can heat-clearing and toxic substances removing, and heat radiation is induced sweat, clearing away heat and cooling blood, the pestilence pathogenic heat of removing summer-heat the four stages in the course of an epidemic febrile disease, can capture brokenly again knot, cleanses Gastrointestinal excess heat stagnant, and person is logical to make plug, and the person of closing is smooth.
We adopt:
Diaphoretic therapy-short " heat " sheds from body surface;
Lung qi dispersing method-short " heat " is sent from lung qi;
Removing heat from blood method-short " heat " appears from nutrient blood.
Except wet method-" wetting ", removing " dysentery " stops.
Prescription is fully theoretical with reference to Chinese veterinarian's differentiation of syndromes in seasonal febrile diseases according to four phases: WEI,QI,YING and XUE systems, giving consideration to both the exterior and interior, and QI and blood is ruled together, embodied again " prevention of diseae ", the prevention thought of " preventing exacerbation after being taken ill ", special by YAOJING, compatibility is careful and precise, the medicine that Fang Zhongwu is irrelevant, without the pole making up the number, without branch, without climing, embodied medication as used military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
Adopt traditional Chinese veterinary medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs theory and traditional medication experience, in conjunction with technical methods such as modern ImmunopharmacologicaResearch and Clinical Veterinary Medicines, Chinese herbal medicine is carried out to prescription screening, form novel multiple power one preparation.It is effective prescription for the treatment of Pullorum Disease and chicken colibacillosis.We are applicable to the stagnant excess-heat obstructed and that cause impairment of dispersing and descending function of the lung, functional activity of QI being not smooth of mechanism of qi Kui and breath with cough; Or the scorching real knot of stomach internal organs, pyretic toxicity interweaves combined into evil, and pyretic toxicity amasss to be contained and hyperpyrexia; Or damp keeps somewhere the intestines and stomach, disorder of water passage and the diarrhea due to damp-heat of small intestinal clear QI being mixed up with turbid QI, all cards of red white dysentery.
Wood research be take Chinese veterinarian's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as carrier, take monarch compatibility theory as support, take modern ImmunopharmacologicaResearch as platform, adopts strong virus attack to consider its clinical drug effect, extensive its immune mechanism of backbone network, and its treatment field is realized in broad region.
The present invention has the following advantages:
1. the industrial policy that meets national veterinary drug exploitation, meets the requirement of producing pollution-free food, people's life health and safety, meets the requirement of development scientific and technological enterprises and enhancing Enterprise Innovation Capability;
2. do not produce the ubiquitous drug resistance problem of prior art;
3. because the present invention is Chinese medicine, and by plant amedica and a small amount of natural minerals, form, with regard to medicine, do not have itself poisonous problem, therefore neither can produce toxic and side effects to animal, also can not have the drug residue problem of prior art.This point has obtained the proof of correlation test;
4. the results showed, medicine character of the present invention and efficacy stability and storage tolerance, storage that can the long period, is also suitable for the transportation of long-distance and adverse circumstances, and this use for medicine is very favourable beyond doubt.
The specific embodiment is the specific embodiment of the present invention below: by prescription of the present invention, accurately take each medicine, both: Flos Lonicerae 11 Kg, Gypsum Fibrosum 13Kg, Radix Paeoniae Rubra 11 Kg, the Radix Pulsatillae 11 Kg, Fructus Forsythiae 6.8Kg, Rhizoma Osmundae 6.8Kg, Radix Sophorae Flavescentis 6.8Kg, Radix Isatidis 8.8Kg, Radix Glycyrrhizae 6.5K, crosses 60 mesh sieves after above-mentioned each medicine drying is pulverized, and gets final product packing standby after mixing.
Corresponding test of the present invention adopts random double blind test method to carry out various dose treatment natural occurrence and the chicken colibacillosis of artificial challenge's morbidity and the therapeutic test of Pullorum Disease, and selects the positive medicine matched group of florfenicol.Observe the present invention to chicken colibacillosis and Pullorum Disease therapeutical effect, to inquire into the feasibility of its application in chicken produces.Test Chinese medicine low dose group: every chicken 1g of the present invention (chicken reduces by half) that feeds every day, connects and feed 5 days; Dosage group in medicine: every chicken 2g of the present invention (chicken reduces by half) that feeds every day, connects and feed 5 days.Medicine high dose group: every chicken 3g of the present invention (chicken reduces by half) that feeds every day, connects and feed 5 days.) experimental result shows, the present invention is loose for the treatment of artificial challenge's Pullorum Disease, and the cure rate of low dose group is 67.8%, total effective rate
Be 83.3%; High, in two dosage groups to the cure rate of Pullorum Disease, be 80%, total effective rate is 90%, mortality rate is only 10%, slightly poorer than florfenicol treatment group; Compare difference extremely significantly (P<0.01) with infection matched group.Treatment to natural occurrence Pullorum Disease, high, middle dosage treatment group cure rate is 80.0%, mortality rate, aggregate efficiency is 10%, 90.0% respectively.The high, medium and low dosage of the present invention has therapeutical effect to Pullorum Disease, can relief of symptoms, reduce mortality rate, and high, middle dosage reducing mortality rate, and the effect that improves the aspects such as cure rate and florfenicol is suitable.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences in 0.05 level, thus dosage in can adopting during clinical use, so not only economic curative effect but also
Significantly.
The present invention is in chicken colibacillosis therapeutic test.Artificial vaccination escherichia coli (O
78) strong toadstool kind 6.5h after, except blank, chicken starts to occur onset state, shows as lassitude, flocks together, necking down, has row's HUANGBAI(sic) loose stool phenomenon.And after treatment group medicine feed 24h, the spirit of medicine group chicken is better than positive controls, but not as negative control group; After 48 h, add up death toll, medicine group chicken is obviously fewer than positive controls death toll; After 72 h, observe, medicine group chicken no longer includes dead generation, and improvement in various degree appears in each group, and positive controls still has dead generation successively.After 4d, spirit, the appetite of medicine group chicken takes a favorable turn (from feeding capacity, increase and find out), and feces is normal; The state of an illness of positive controls is more and more heavier, continues to occur dead.From therapeutic effect, the cure rate of low dose group of the present invention is 65.0%, and total effective rate is 82.5%; High dose group and two groups of middle dosage group can reach more than 70% curative effect, total effective rate reaches 87.5%, cure rate and florfenicol treatment group are without significant difference (P>0.05), effective percentage is slightly poorer than florfenicol treatment group, compares difference extremely significantly (P<0.01) with infection matched group.
Treatment to natural occurrence chicken colibacillosis, high, middle dosage is to the effect of therapeutic effect and florfenicol suitable (total effective rate is all 90.0%).The therapeutic effect of low dose group (total effective rate is 86.6%) is lower than high, middle dosage group, middle and high dosage group aspect mortality rate, cure rate and total effective rate all without significant difference; High, the middle dosage group therapeutic effect of 5 days is all significantly higher than the therapeutic effect of 3 days.
From result of the test, the present invention has heat-clearing and toxic substances removing, dehumidifying dysentery relieving, the functions such as strengthening vital QI to eliminate pathogenic factors.In clinical trial process, do not find that this medicine has untoward reaction.High, medium and low dosage has good therapeutic effect to Pullorum Disease and chicken colibacillosis, and high, middle dosage is suitable to the effect of therapeutic effect and florfenicol.The therapeutic effect of low dose group is lower than high, middle dosage group, middle and high dosage group there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to the weight of the state of an illness and treatment cost, suggestion clinical practice for well, is used in conjunction 4 ~ 5 days with middle dosage (every lkg feedstuff 10 ~ 20g, chicken reduces by half).3 days chicken groups' of test medication the state of an illness can be controlled, and death toll no longer significantly rises, but now a continuation medication can be accelerated the rehabilitation of chicken, prevents the recurrence of the state of an illness.In addition, the present invention has similar effect for preventing and treating colibacillosis and the Hakuri of domestic animal.For clear and definite novel anti-infection herbal medicine compound preparation toxic and side effects of the present invention, to its safety is made accurately, objective appraisal, for clinical trial medication provides scientific basis, guarantee clinical drug safety, carried out toxicity test of the present invention.
By mice is carried out to LD of the present invention
50people's tolerance test shows, after design dosage oral administration, respectively organizes mice behavior sign in 7 days normal, all do not occur poisoning symptom and death.Therefore cannot measure LD
50, and have to take maximum dosage-feeding 80g/kg as maximum dose level.After within the 8th day, slaughtering, each organizes mice organs all without pathological changes, and pathological characters is not found in liver,kidney,spleen histological examination yet.Hemogram and serum GPT are active to be detected, result and normal mouse there was no significant difference.In the toxicity test result of chicken being carried out to body animal, show, said preparation is in whole feeding experiment process, and experimental chicken well-grown, also has no any toxic and side effects, consistent with the result of experiment mice.Low or the almost non-toxic side effect of toxic and side effects of the present invention is described, clinically takes 3-6 days safety.
In order to grasp, because using continuously Chinese herb compound the present invention to produce toxicity and corpse, " heavy degree, and the development after drug withdrawal and recovery situation, provide reference for drafting data for clinical drug use dosage.On mice, carried out subacute toxicity test of the present invention, within experimental period, except high dose group because of drug dose cause greatly palatability poor affect ingest, all the other respectively organize mice diet, behavior, and feces is all normal, physically well develop, without any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. are all without obvious poisoning pathological changes.By the 3-4 of the clinical application amount 30d that doubly feeds, also have no toxic and side effects, the clinical medicine dose that said preparation is described is very safe.
This product is according to listing terms of packing, in temperature: 40 ℃ ± 2 ℃, and relative humidity: accelerate 3 months under 75% ± 5% condition, quality is without significant change.In temperature: 25 ℃ ± 2 0C relative humiditys: under 60% ± 10% condition, long term test is 22 months, and quality is without significant change.Above-mentioned result of the test shows, this product storage quality under rated condition is stable, can store for a long time.
Claims (1)
1. the application of the veterinary drug for the treatment of colibacillosis and Hakuri in regulating drug, is characterized in that pharmaceutical formulation is:
Flos Lonicerae 110 ± 5% weight portion Gypsum Fibrosum 130 ± 5% weight portions
Radix Paeoniae Rubra 110 ± 5% weight portion Radix Pulsatillae 110 ± 5% weight portions
Fructus Forsythiae 65 ± 3% weight portion Rhizoma Osmundae 65 ± 3% weight portions
Radix Sophorae Flavescentis 65 ± 3% weight portion Radix Isatidis 85 ± 5% weight portions
Radix Glycyrrhizae 65 ± 3% weight portions.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310545394.4A CN103550314A (en) | 2013-11-07 | 2013-11-07 | Veterinary medicine for treating colibacillosis and white diarrhea |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310545394.4A CN103550314A (en) | 2013-11-07 | 2013-11-07 | Veterinary medicine for treating colibacillosis and white diarrhea |
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| CN103550314A true CN103550314A (en) | 2014-02-05 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977058A (en) * | 2014-05-26 | 2014-08-13 | 山东省农业科学院家禽研究所 | Chinese herbal medicine oral liquid for preventing and treating chicken colibacillosis and production process thereof |
| CN104306881A (en) * | 2014-10-10 | 2015-01-28 | 天津瑞贝特科技发展有限公司 | Injection for preventing and treating poultry escherichia coli diseases and preparation method of injection |
| CN106177110A (en) * | 2016-07-31 | 2016-12-07 | 台江县大营家禽生态养殖农民专业合作社 | A kind of Chinese medicine preparation preventing and treating epidemic diarrhea of laying hen |
-
2013
- 2013-11-07 CN CN201310545394.4A patent/CN103550314A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977058A (en) * | 2014-05-26 | 2014-08-13 | 山东省农业科学院家禽研究所 | Chinese herbal medicine oral liquid for preventing and treating chicken colibacillosis and production process thereof |
| CN103977058B (en) * | 2014-05-26 | 2017-03-29 | 山东省农业科学院家禽研究所 | A kind of Chinese herbal medicament oral liquid and production technology of preventing and treating chicken colibacillosis |
| CN104306881A (en) * | 2014-10-10 | 2015-01-28 | 天津瑞贝特科技发展有限公司 | Injection for preventing and treating poultry escherichia coli diseases and preparation method of injection |
| CN106177110A (en) * | 2016-07-31 | 2016-12-07 | 台江县大营家禽生态养殖农民专业合作社 | A kind of Chinese medicine preparation preventing and treating epidemic diarrhea of laying hen |
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Application publication date: 20140205 |
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