CN106109831A - A kind of veterinary drug that can improve immunity of livestock - Google Patents
A kind of veterinary drug that can improve immunity of livestock Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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Abstract
The invention discloses a kind of veterinary drug that can improve immunity of livestock, it is made up of following material medicine, calculate by mass percentage, Wu Ling ginseng 3.48~8.70%, the Radix Astragali 8.70~26.09%, Herba Euphorbiae Humifusae 8.70~17.40%, Radix Gomphostemmae 5.22~26.09%, Herba Gerberae Piloselloidis 4.35~13.04%, Radix Agrimoniae 8.70~13.91%, Herba Artemisiae annuae 1.74~3.48%, Rhizoma Dioscoreae 8.70~13.91%, Cortex Dictamni 2.61~7.83%, Semen Cuscutae 4.35~13.04%, above component makes powder or other dosage form according to aforementioned proportion.Veterinary drug preparation of the present invention has the functions such as QI invigorating, consolidating superficial resistance, yang invigorating, heat clearing away, removing toxic substances, can strengthen immunity of livestock, reduces the generation of disease, promotes growth of animals or poultry, improves culture benefit.
Description
Technical field
The present invention relates to a kind of veterinary drug that can improve immunity of livestock.
Background technology
At present, livestock and poultry breeding industry, in order to prevent disease and treatment disease, generally gives the substantial amounts of antibiotic of poultry feeding, hormone
And other antibacterials, owing to antibiotic and hormone retain in poultry body for a long time in a large number, not only affect animal products quality,
In meat products and egg products, harmful material residual is too high simultaneously, threatens the food safety of the mankind.Chemical feed adds
The production of agent also can be to environment.Avoid using chemical addition agent, pay attention to food safety, advocate green health and cultivated
Become the development trend of aquaculture.Therefore, the veterinary drug health-care additive of exploitation environmental protection is the most necessary.
Summary of the invention
The purpose of the present invention aims to provide the veterinary drug that can improve immunity of livestock of a kind of environmental protection.
For completing above-mentioned purpose, the technical solution of the present invention is: a kind of veterinary drug that can improve immunity of livestock, its
It is made up of following material medicine, calculates by mass percentage, Wu Ling ginseng 3.48~8.70%, the Radix Astragali 8.70~26.09%,
Brocade grass 8.70~17.40%, Radix Gomphostemmae 5.22~26.09%, Herba Gerberae Piloselloidis 4.35~13.04%, Radix Agrimoniae 8.70~
13.91%, Herba Artemisiae annuae 1.74~3.48%, Rhizoma Dioscoreae 8.70~13.91%, Cortex Dictamni 2.61~7.83%, Semen Cuscutae 4.35~
13.04%, each composition sum is 100%.
Further, described a kind of veterinary drug that can improve immunity of livestock, preferably it is made up of following material medicine, presses
Mass percent calculate, Wu Ling ginseng 6.09%, the Radix Astragali 17.4%, Herba Euphorbiae Humifusae 13.04%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%,
Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae 11.3%, Cortex Dictamni 5.22%, Semen Cuscutae 8.70%.
Further, described a kind of veterinary drug that can improve immunity of livestock, each material composition of this veterinary drug is mixed, warp
Micronizing makes powder veterinary drug.May also be fabricated which and be available for husbandry sector or other dosage forms of veterinary clinic application.
Further, the application of described a kind of veterinary drug that can improve immunity of livestock, is according to quality 1.5 by this veterinary drug
~the ratio of 3.5% adds in poultry normal feedstuff, within every 2 weeks, using once, one-time continuous feeds 2~3 days, as daily maintenence
Health care usage amount.
Further, the application of described a kind of veterinary drug that can improve immunity of livestock, preferably said composition is made
Veterinary drug add in poultry normal feedstuff according to the ratio of quality 2%, within every 2 weeks, use once, one-time continuous feeds 2~3 days, work
For daily maintenence health care usage amount.
Beneficial effects of the present invention:
The kinds of traditional Chinese medicines compatibility of the present invention uses, the most collaborative, is permitted mutually to be added, and common effect shows as having QI invigorating, consolidating superficial resistance, liter
The functions such as sun, heat clearing away, removing toxic substances, it is possible to increase immunity of livestock, prevention digestive tract and the generation of respiratory tract common disease, it is also possible to
In treatment livestock and poultry alimentary tract and the disease of respiratory tract;The present invention prevents the effect of livestock and poultry notable, action temperature and, nontoxic secondary make
With;Animal products drug residue free;Growth of animals or poultry can be promoted, improve culture benefit;This herbal medicine production technology is simple, use
Convenient, raw material is easy to get, with low cost, is a kind of preferably animal health-care product.
Beneficial effects of the present invention is proved below by the test of pesticide effectiveness.
Test example one: preventing poultry diseases is tested
1. test method
Selecting the hen of 14 ages in days, sheldrake, each 200 of Taihu goose to carry out packet raising, often group 100 respectively, one group when feeding
Adding veterinary drug of the present invention in feedstuff, the mass percent of each material composition of veterinary drug of the present invention used is crow spirit ginseng 6.09%, the Radix Astragali
17.4%, Herba Euphorbiae Humifusae 13.04%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae
11.3%, Cortex Dictamni 5.22%, Semen Cuscutae 8.70%, by dried for above-mentioned veterinary drug micronizing, the veterinary drug after pulverizing is according to quality
The ratio of 2% adds in poultry normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 3 days, and another group as a control group, is raised
Without veterinary drug of the present invention in material, in addition, the rearing conditions of two groups is identical, and immune programme for children is identical, the individual diversity in two groups
Different control in the reasonable scope, is raised and is added up sickness rate and mortality rate during 56 age in days.
2. result
Be shown in Table 1, table 2.
Digestive tract disease sickness rate and experience table are raised in table 1 chicken, duck, goose packet
Respiratory tract disease sickness rate and experience table are raised in table 2 chicken, duck, goose packet
3. conclusion
By table 1, table 2 it can be seen that periodically feed veterinary drug of the present invention after, chicken, duck, goose infect digestive tract and respiratory tract disease
Probability reduces, and mortality rate is reduced to 0, illustrates that the veterinary drug of the present invention can improve immunity of poultry, reduces digestive tract and respiratory tract
The sickness rate of disease, reduces mortality rate, improves culture benefit, increases cultivation income, is a new technique being worthy to be popularized.
Test example two: the impact on newcastle disease immune effect, body weight and Immune Organs Index is tested
1. test method,
(1) EXPERIMENTAL DESIGN
Choose 120 1 age in days broiler chicks and be randomly divided into 3 groups, often 40 chickens of group.It is divided into matched group, test A and B group.All broiler
The head carrying out newcastle (ND) La Sota vaccine in 7 and 21 ages in days respectively exempts to exempt from two, and immunization method is collunarium, eye dripping.
The mass percent of each composition of veterinary drug of the present invention used by test A group broiler be crow clever join 6.09%, the Radix Astragali 17.4%,
Brocade grass 13.04%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae 11.3%, shaggy-fruited dittany
Skin 5.22%, Semen Cuscutae 8.70%, by dried for above-mentioned veterinary drug micronizing, the veterinary drug after pulverizing is according to the ratio of quality 1.5%
Being added in the normal feedstuff of chicken, begin to use veterinary drug of the present invention, within every 2 weeks, use once during 3 age in days, one-time continuous feeds 3 days.
The veterinary drug that test B group broiler uses is identical with test A group of formula and processing method, adds according to the ratio of quality 2%
In the normal feedstuff of chicken, beginning to use veterinary drug of the present invention, within every 2 weeks, use once during 3 age in days, one-time continuous feeds 3 days.
Matched group normally feeds complete feedstuff, does not use veterinary drug of the present invention.
(2) broiler weight measures
The body weight of broiler is weighed when off-test.
(3) mensuration of Immune Organs Index
During off-test, sacrificed by exsanguination broiler, aseptic dissection, take whole spleen and fabricius bursa, blot its surface bloodstain, weigh,
Calculate spleen and bursal index.
(4) antibody test
After within after within l days and head before head exempts from, exempting from respectively 7,14 and 21 days and two, exempting from 7 and 14 days, often group randomly drawed 8 chickens, wing vein
Blood sampling, separates out serum.Measuring ND antibody titer with β-hemagglutination inhibition test (HI), seek the meansigma methods often organized, result is with X × log2
Represent.
(5) data process
Application SPSS17.0 software is to Data Analysis Services.Data represent with mean+SD, compare by the t method of inspection
Relatively, P < 0.05 is significant difference, and P > 0.05 difference is the most notable.
2. result
(1) on broiler weight and the impact of Immune Organs Index
As seen from Table 3: test A and B group Broiler Chicken weight average relatively matched group dramatically increases.The spleen of test A and B group broiler and fabricius bursa
Index is above matched group, significant difference.And no significant difference between test group, but test B group is higher than test A group.
Table 3 is on broiler weight and the impact of Immune Organs Index
Note: represent notable with matched group comparing difference with column data shoulder mark.
(2) serum antibody titer measurement result
As seen from Table 4: head exempts from first 1 day and head to exempt to record each group of antibody horizontal 7 days suitable, test A group from head exempt from 21 days to start with
Matched group significant difference;Test B group head is exempted from 14 days to start and matched group significant difference.
Table 4 newcastle disease HI antibody titer statistical result
Note: represent notable with matched group comparing difference with column data shoulder mark.
3. conclusion
Result shows: during ND vaccine immunity, and veterinary drug of the present invention can significantly improve the body weight of broiler and immune organ refers to
Number.
Test shows, ND-HI serum antibody titer exempts from 21 days to start to dramatically increase at head.And the generation of antibody and the present invention
The consumption of veterinary drug has relation.Veterinary drug of the present invention, in chicken ND immunologic process, is favorably improved the immunologic function of broiler.Therefore, originally
Invention veterinary drug, as the effective immunostimulant of one, has value on husbandry sector and veterinary clinic.
Test example three: prevention swine diseases test
1. test method
The black pig of ternary 200 selecting 7 ages in days carries out packet and raises, often group 100, and one group is added the present invention when feeding in feedstuff
Veterinary drug, the mass percent of each material composition of veterinary drug of the present invention used is crow spirit ginseng 6.09%, the Radix Astragali 17.4%, Herba Euphorbiae Humifusae
13.04%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae 11.3%, Cortex Dictamni
5.22%, Semen Cuscutae 8.70%, will mix after the raw material drying of above-mentioned veterinary drug, micronizing, and the veterinary drug after pulverizing is according to quality
The ratio of 2% adds in pig normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 3 days, and another is organized as a control group, feedstuff
In without veterinary drug of the present invention, in addition, the rearing conditions of two groups controls identical, and immune programme for children is identical, in two groups
Individual variation controls in the reasonable scope, raises and adds up sickness rate and mortality rate during 56 age in days.
2. result
It is shown in Table 5.
Table 5 test pig incidence and mortality statistical table
3. conclusion
As can be seen from Table 1, after periodically feeding veterinary drug of the present invention, the sickness rate of pig infectious disease reduces, and mortality rate is reduced to 0,
Illustrate that the veterinary drug of the present invention can improve immunity of livestock, reduce the sickness rate of swine diseases, reduce mortality rate, improve culture benefit,
Increase cultivation income.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further.
Embodiment 1: the present embodiment is made up of following raw materials according: calculate by mass percentage, Wu Ling ginseng 6.09%, the Radix Astragali
17.4%, Herba Euphorbiae Humifusae 13.04%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae
11.3%, Cortex Dictamni 5.22%, Semen Cuscutae 8.70%.The chopping of the most each composition is dried, and is sufficiently mixed, makes powder through micronizing
Shape veterinary drug, adds in poultry normal feedstuff according to the ratio of quality 1.5~3.5%, and once, one-time continuous feeds 2 in use in every 2 weeks
~3 days, use as daily maintenence health care.
Embodiment 2: the present embodiment is made up of following raw materials according: calculate by mass percentage, Wu Ling ginseng 6.09%, the Radix Astragali 30%,
Herba Euphorbiae Humifusae 11.91%, Radix Gomphostemmae 7%, Herba Gerberae Piloselloidis 5%, Radix Agrimoniae 10%, Herba Artemisiae annuae 2%, Rhizoma Dioscoreae 10%, Cortex Dictamni 3%, Semen Cuscutae
15%.The chopping of the most each composition is dried, be sufficiently mixed, make powder veterinary drug through micronizing, according to quality 1.5~3.5%
Ratio adds in poultry normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 2~3 days, uses as daily maintenence health care.
Embodiment 3: the present embodiment is made up of following raw materials according: calculate by mass percentage, Wu Ling ginseng 4%, the Radix Astragali 10%,
Brocade grass 10%, Radix Gomphostemmae 15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 4%, Rhizoma Dioscoreae 16%, Cortex Dictamni 9%, Tu
SIZI 11.36%.The chopping of the most each composition is dried, and is sufficiently mixed, makes powder veterinary drug through micronizing, according to quality 1.5~
The ratio of 3.5% adds in poultry normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 2~3 days, protects as daily maintenence
Strong use.
Embodiment 4: the present embodiment is made up of following raw materials according: calculate by mass percentage, Wu Ling ginseng 10%, the Radix Astragali 17.4%,
Herba Euphorbiae Humifusae 20%, Radix Gomphostemmae 6%, Herba Gerberae Piloselloidis 15%, Radix Agrimoniae 10%, Herba Artemisiae annuae 2.4%, Rhizoma Dioscoreae 10%, Cortex Dictamni 4.2%, Herba cuscutae
Son 5%.The chopping of the most each composition is dried, be sufficiently mixed, make powder veterinary drug through micronizing, according to quality 1.5~3.5%
Ratio adds in poultry normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 2~3 days, uses as daily maintenence health care.
Embodiment 5: the present embodiment is made up of following raw materials according: calculate by mass percentage, Wu Ling ginseng 4%, the Radix Astragali 10%,
Brocade grass 10%, Radix Gomphostemmae 30%, Herba Gerberae Piloselloidis 6.3%, Radix Agrimoniae 16%, Herba Artemisiae annuae 2%, Rhizoma Dioscoreae 10%, Cortex Dictamni 3%, Semen Cuscutae
8.7%.The chopping of the most each composition is dried, be sufficiently mixed, make powder veterinary drug through micronizing, according to quality 1.5~3.5%
Ratio adds in poultry normal feedstuff, within every 2 weeks, uses once, and one-time continuous feeds 2~3 days, uses as daily maintenence health care.
Claims (8)
1. the veterinary drug that can improve immunity of livestock, it is characterised in that: it is made up of following material medicine, by quality
Percentage calculation, Wu Ling ginseng 3.48~8.70%, the Radix Astragali 8.70~26.09%, Herba Euphorbiae Humifusae 8.70~17.40%, Radix Gomphostemmae 5.22~
26.09%, Herba Gerberae Piloselloidis 4.35~13.04%, Radix Agrimoniae 8.70~13.91%, Herba Artemisiae annuae 1.74~3.48%, Rhizoma Dioscoreae 8.70~
13.91%, Cortex Dictamni 2.61~7.83%, Semen Cuscutae 4.35~13.04%, each composition sum is 100%.
2. a kind of veterinary drug that can improve immunity of livestock as described in claim 1, it is characterised in that: it is by following former
Material medicine is made, and calculates by mass percentage, Wu Ling ginseng 6.09%, the Radix Astragali 17.4%, Herba Euphorbiae Humifusae 13.04%, Radix Gomphostemmae
15.64%, Herba Gerberae Piloselloidis 8.7%, Radix Agrimoniae 11.3%, Herba Artemisiae annuae 2.61%, Rhizoma Dioscoreae 11.3%, Cortex Dictamni 5.22%, Semen Cuscutae
8.70%。
3. a kind of veterinary drug that can improve immunity of livestock as described in claim 1, it is characterised in that: each by this veterinary drug
Material composition mixes, and makes powder veterinary drug through micronizing.
4. the application of a kind of veterinary drug that can improve immunity of livestock as described in claim 1, it is characterised in that: by this beast
Medicine adds in poultry normal feedstuff according to the ratio of quality 1.5~3.5%, and once, one-time continuous feeds 2~3 days in use in every 2 weeks,
As daily maintenence health care usage amount.
5. the application of a kind of veterinary drug that can improve immunity of livestock as described in claim 1, it is characterised in that: by this beast
Medicine adds in poultry normal feedstuff according to the ratio of quality 2%, within every 2 weeks, uses once, and one-time continuous feeds 2~3 days, as day
Often prevention and health care usage amount.
6. the application in preparation has the animal health medicine improving immunity of livestock of the compositions as described in claim 1.
7. the compositions as described in claim 1 is in preparation has the animal health medicine of preventing and treating disease of alimentary tract of livestock husbandry and birds
Application.
8. the compositions as described in claim 1 is in preparation has the animal health medicine of preventing and treating livestock and birds respiratory disease
Application.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101670061A (en) * | 2009-08-26 | 2010-03-17 | 郑州后羿制药有限公司 | Veterinary drug for treating respiratory tract infection of poultry and preparation method thereof |
CN103494996A (en) * | 2013-09-29 | 2014-01-08 | 青岛农业大学 | Pharmaceutical composition for improving immunity of livestock and poultry and preparation method of pharmaceutical composition |
CN104337976A (en) * | 2013-07-31 | 2015-02-11 | 瑞普(天津)生物药业有限公司 | Traditional Chinese medicine composition for improving immunity of beasts and birds |
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2016
- 2016-08-16 CN CN201610672874.0A patent/CN106109831A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101670061A (en) * | 2009-08-26 | 2010-03-17 | 郑州后羿制药有限公司 | Veterinary drug for treating respiratory tract infection of poultry and preparation method thereof |
CN104337976A (en) * | 2013-07-31 | 2015-02-11 | 瑞普(天津)生物药业有限公司 | Traditional Chinese medicine composition for improving immunity of beasts and birds |
CN103494996A (en) * | 2013-09-29 | 2014-01-08 | 青岛农业大学 | Pharmaceutical composition for improving immunity of livestock and poultry and preparation method of pharmaceutical composition |
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