CN104206710B - Traditional Chinese medicinal feed additive containing N-carbamylglutamic acid, and its application - Google Patents
Traditional Chinese medicinal feed additive containing N-carbamylglutamic acid, and its application Download PDFInfo
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- CN104206710B CN104206710B CN201410401869.7A CN201410401869A CN104206710B CN 104206710 B CN104206710 B CN 104206710B CN 201410401869 A CN201410401869 A CN 201410401869A CN 104206710 B CN104206710 B CN 104206710B
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Abstract
The invention discloses a traditional Chinese medicinal feed additive containing N-carbamylglutamic acid, and its application. The above composition contains Radix Scutellariae, Radix Astragali, white peony root, honeysuckle flower, dried orange peel, licorice root and N-carbamylglutamic acid. The feed additive has the advantages of simple production technology, easily available raw materials, no hormones, improvement of the anti-stress capability of livestock, improvement of the immune function of the livestock, disease prevention, enhancement of the appetite of the livestock, and feed conversion rate improvement.
Description
Technical field
The present invention relates to a kind of feed additive and its application;More particularly to a kind of Chinese medicine containing N- carbamylglutamic acids is raised
Feed additives and its application, belong to feedstuff preparation field.
Background technology
It is also to be substantially increased to fowl egg meat demand with the improvement of people's living standards.In order to improve fowl egg meat
Yield, each Feed Enterprise studied the nutritional labeling and the mechanism of action of feedstuff, develops various feed additives, its
In just include Chinese medicine feed additive.General Chinese medicine feed additive has toxic and side effects little, is not likely to produce Drug resistance, can press down
The features such as system and killing antibacterial, raising anti-stress ability and immunity of organisms, appetite stimulator.But Chinese medicine feed additive is in reality
But there is the shortcomings of consumption is big, action is slow in the use of border.
N- carbamylglutamic acids are the metabolic stability analog of N-acetylglutamat, can activate the limit of the endogenous synthesis of arginine
Fast enzyme-carbamyl phosphate synthetase -1, so as to improve arginic endogenous synthesis.And arginine race aminoacid is in regulation and control body
Nutrition and Metabolism and immunoreation aspect play an important role.
Develop a kind of easy production, easily addition, without hormone, the feeding that poultry immune function can be improved, improved food conversion ratio
Feed additives tool is of great significance.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine feed additive containing N- carbamylglutamic acids and its application.
The present invention provides a kind of compositionss, containing Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- carbamyls
Glutamic acid.
In above-mentioned composition, the compositionss are by Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- carbamyls
Glutamic acid is constituted.
In any of the above-described described compositionss, the Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- ammonia first
The mass ratio of acyl glutamic acid is 15:(10-25):(15-20):(5-12):(7-10):(5-12):(30-60).
In any of the above-described described compositionss, the Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- ammonia first
The mass ratio of acyl glutamic acid is 10:15:10:8:5:8:30, or 15:10:20:5:10:5:30, or 10:15:10:8:5:8:40,
Or 15:10:20:5:10:5:40.
In any of the above-described described compositionss, the production method of the N- carbamylglutamic acids is with reference to Application No.
200810187671.8, notification number is CN101440042, and the invention of entitled " N- carbamylglutamic acid preparation methoies " is special
Profit;
The Radix Scutellariae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0016;
The Radix Astragali is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0069;
The Radix Paeoniae Alba is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0013;
The Flos Lonicerae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0323;
The Pericarpium Citri Reticulatae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0147;
The Radix Glycyrrhizae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0560.
A kind of forage mixture falls within protection scope of the present invention, is by basic feedstuff and any of the above-described described combination
Thing is mixed to get.
In above-mentioned forage mixture, any of the above-described described compositionss and basic quality of the fodder ratio are 0.01-
0.03:100, specially 0.01:100、0.02:100 or 0.03:100;
The basic feedstuff is perfect compound feed;
The perfect compound feed is purchased from He Feng groups, and catalog number is 1040T.
Application of any of the above-described described compositionss as additive in animal feed is prepared falls within the guarantor of the present invention
Shield scope;
Or,
Application of any of the above-described described compositionss in the product for improving breeding performonce fo animals is prepared falls within the present invention
Protection domain;
The production performance is specially growth rate or feed conversion rate;
Or,
Any of the above-described described compositionss answering in the product for improving animal body immunocompetence or stress ability is prepared
With falling within protection scope of the present invention.
Application of any of the above-described described forage mixture in animal feed is prepared falls within protection scope of the present invention;
Or,
Application of any of the above-described described forage mixture in the product for improving breeding performonce fo animals is prepared falls within this
The protection domain of invention;
The production performance is specially growth rate or feed conversion rate;
Or,
Any of the above-described described forage mixture is in the product for improving animal body immunocompetence or stress ability is prepared
Application fall within protection scope of the present invention.
In any of the above-described described application, the animal is the animal in growing and fattening stage;
The animal is specially pig.
The feed additive of the present invention is due to adding the Chinese herbal medicine such as Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae
Composition, can strengthen animal body immunity, improve anti-stress ability, while the absorption of nutrient substance can also be promoted, can prevent and
Treatment digestive tract, respiratory tract and urogenital infections, noresidue, without Drug resistance.The feed additive of the present invention is also added into
N- carbamylglutamic acids, can improve arginic endogenous synthesis, and arginine race aminoacid is in regulation and control body Nutrition and Metabolism and exempts from
Epidemic disease reaction aspect plays an important role.
The feed additive production process is simple that the present invention is provided, raw material is easy to get, without hormone, it is possible to increase poultry is anti-should
Sharp ability, improves poultry immune function, and prevention disease occurs, and promotes poultry appetite, improves food conversion ratio.
Specific embodiment
Experimental technique used in following embodiments if no special instructions, is conventional method.
Material used, reagent etc. in following embodiments, if no special instructions, commercially obtain.
N- carbamylglutamic acids are prepared by emerging (Beijing) Science and Technology Ltd. of herding in Asia-Pacific, and its production method is with reference to Application No.
200810187671.8, notification number is CN101440042, and the invention of entitled " N- carbamylglutamic acid preparation methoies " is special
Profit.
The raw material of Chinese medicine can be Chinese crude drug, the alternatively prepared slices of Chinese crude drugs
Radix Scutellariae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0016.
The Radix Astragali is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0069.
Radix Paeoniae Alba is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0013.
Flos Lonicerae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0323.
Pericarpium Citri Reticulatae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0147.
Radix Glycyrrhizae is purchased from Beijing Shi Zhen Chinese herbal medicine Technology Co., Ltd., and catalog number is A0560.
Perfect compound feed is purchased from He Feng groups, and catalog number is 1040T.
Embodiment 1, Chinese medicine feed additive 1
Radix Scutellariae 10g, Radix Astragali 15g, Radix Paeoniae Alba 10g, Flos Lonicerae 8g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 8g, N- carbamylglutamic acids are taken respectively
30g, is ground into mix homogeneously after powder, obtains final product Chinese medicine feed additive 1.
Embodiment 2, Chinese medicine feed additive 2
Radix Scutellariae 15g, Radix Astragali 10g, Radix Paeoniae Alba 20g, Flos Lonicerae 5g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 5g, N- carbamyl paddy ammonia are taken respectively
Sour 30g, is ground into mix homogeneously after powder, obtains final product Chinese medicine feed additive 2.
Embodiment 3, Chinese medicine feed additive 3
Radix Scutellariae 10g, Radix Astragali 15g, Radix Paeoniae Alba 10g, Flos Lonicerae 8g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 8g, N- carbamylglutamic acids are taken respectively
40g, is ground into mix homogeneously after powder, obtains final product Chinese medicine feed additive 3.
Embodiment 4, Chinese medicine feed additive 4
Radix Scutellariae 15g, Radix Astragali 10g, Radix Paeoniae Alba 20g, Flos Lonicerae 5g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 5g, N- carbamyl paddy ammonia are taken respectively
Sour 40g, is ground into mix homogeneously after powder, obtains final product Chinese medicine feed additive 4.
Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, N- carbamylglutamic acids are ground into after powder, according to matter
Amount is than being 15:(10-25):(15-20):(5-12):(7-10):(5-12):(30-60) mix homogeneously, can be made into Chinese medicine feeding
Feed additives.
Embodiment 5, N- carbamylglutamic acids (NCG) are to the production performance of pig and the impact of Serum Indexes
First, choose that body weight is close, (male and female is each for " DLY " tri-crossbreeding 160 of the subuniform 25kg of tire or so
Half), it is randomly divided into 4 groups, 40 per group, 4 repetitions of each group, each repeats 10.Per group is carried out at random in table 1 at any one
As shown in table 1, in table 1, NCG is made an addition in perfect compound feed, such as reason, per group of raising stage and additive addition
0.01%NCG represents extra addition 0.01gNCG in 100g perfect compound feeds.Feed mode adopts group feeding, daily feeding two
Secondary, free water, other management are carried out according to a conventional method.
The experimental design of table 1
Group | The raising stage | Additive addition |
Experiment A | Growing and fattening stage | 0.01%NCG |
Experiment B | Growing and fattening stage | 0.02%NCG |
Experiment C | Growing and fattening stage | 0.03%NCG |
Matched group | Growing and fattening stage | Without |
2nd, in feeding corresponding feed daystart, the feeding situation and pig health status of every group of pig, experiment periods are observed
For 90 days.Experiment starts and tests to terminate to claim individual weight on an empty stomach, records daily feed intake, calculates daily gain (ADG), daily ingestion amount
(ADFI), feed conversion rate (F/G).Wherein feed conversion rate (F/G)=daily ingestion amount (ADFI)/daily gain (ADG).
As a result it is as shown in table 2.
Table 2 respectively processes the impact to Performance of Finishing Pigs
Note:Same row difference lowercase letter indication difference significantly (p<0.05).
Table 2 shows that its production performance of addition NCG is superior to matched group in growing and fattening stage feedstuff, and tests B groups most
It is good.Compared with matched group, the feed conversion rate for testing A, B and C group has been respectively increased 0.3%, 0.6% and 0.3%.
3rd, experiment terminates the same day and butchers, and butchering the same day, each of per group repeats to randomly select 1 pig, early morning on an empty stomach,
Every pig ear vein blood sampling 10ml or so.Immediately (3000r/min) is centrifuged after blood specimen collection, takes upper serum, 0 DEG C of preservation is standby
With.
Each serum is adopted on U.S.'s Beckman Array System Protein automatic lmunoassays analyzers and is scattered
Speed immunoturbidimetry detection each group serum immune globulin (IgG, IgA, IgM) and Complement C_3, the level of C4, as a result such as table 3
It is shown.
The impact of the clear immune indexes of the treating blood disorderss everywhere of table 3
IgG | IgM | IgA | C3 | C4 | |
Experiment A | 966.25±15.98a | 63.01±5.06 | 12.14±1.37b | 1.58±0.02 | 1.55±0.05 |
Experiment B | 970.78±16.50a | 64.16±5.28 | 12.40±1.25b | 1.59±0.02 | 1.59±0.08 |
Experiment C | 959.79±16.64a | 61.99±5.93 | 12.20±1.52b | 1.55±0.02 | 1.58±0.04 |
Matched group | 871.10±15.24b | 61.02±4.03 | 10.94±1.43a | 1.50±0.01 | 1.51±0.05 |
Note:Same row difference lowercase letter indication difference significantly (p<0.05), different capitalizations represent that difference is extremely notable
(p<0.01)。
Table 3 shows that the serum immune globulin (IgG, IgA, IgM) of each experimental group and Complement C_3, the level of C4 are more right
All it is improved according to group, improves immunity, wherein experiment B group best results.
Experiment shows that NCG can improve poultry immune function, improve food conversion ratio.
Production performance and Serum Indexes of the Chinese medicine feed additive of embodiment 6, carbamylglutamic acid containing N- (NCG) to pig
Impact
First, choose that body weight is close, (male and female is each for " DLY " tri-crossbreeding 160 of the subuniform 25kg of tire or so
Half), it is randomly divided into 4 groups, 40 per group, 4 repetitions of each group, each repeats 10.At per group of any one carried out at random in table 4
As shown in table 4, in table 4, NCG and/or Chinese herbal medicine make an addition to full price and coordinate feeding for reason, per group of raising stage and additive addition
In material, such as 0.02% (NCG and Chinese herbal medicine are combined) represents extra addition 0.02g NCG and medium-height grass in 100g perfect compound feeds
The ratio of drug composition, NCG and various Chinese herbal medicine is as described in Example 1.Feed mode adopts group feeding, daily feeding twice, from
By drinking water, other management are carried out according to a conventional method.Experimental period starts from September 8 in 2013, and in Zhuozhou, Experimental Base is carried out,
100 days experimental periods.
The experimental design of table 4
(in table 4, the ratio for testing each composition of the Chinese herbal medicine of B groups is as follows:10g Radix Scutellariaes:The 15g Radixs Astragali:10g Radix Paeoniae Alba:8g
Flos Lonicerae:5g Pericarpium Citri Reticulataes:8g Radix Glycyrrhizaes)
2nd, daystart is tested, observes the feeding situation and pig health status of every group of pig, experiment starts and test knot
Beam claims on an empty stomach individual weight, records daily feed intake, calculates daily gain (ADG), daily ingestion amount (ADFI) and feed conversion rate
(F/G).Wherein feed conversion rate (F/G)=daily ingestion amount (ADFI)/daily gain (ADG).
As a result it is as shown in table 5.
Table 5 respectively processes the impact to Performance of Finishing Pigs
Note:Same row difference lowercase letter indication difference significantly (p<0.05).
Table 5 shows, NCG, Chinese herbal medicine, NCG and the compositionss of Chinese herbal medicine its productivitys are added in growing and fattening stage feedstuff
Matched group can be superior to, and adds the experimental group best results of NCG and herbal composite.Compared with matched group, experiment A, B and
The feed conversion rate of C groups has been respectively increased 0.63%, 0.63% and 0.94%.
3rd, test the end same day to butcher, butchering the same day, per group each repeating groups randomly select 1 pig, and early morning is empty
Abdomen, every pig ear vein blood sampling 10ml or so.Immediately (3000r/min) is centrifuged after blood specimen collection, takes upper serum, 0 DEG C of preservation
It is standby.
Dissipated using serum is adopted on U.S.'s Beckman Array System Protein automatic lmunoassays analyzers
Firing rate rate immunoturbidimetry detection each group serum immune globulin (IgG, IgA, IgM) and Complement C_3, the level of C4, as a result such as table
Shown in 6.
The impact of the clear immune indexes of the treating blood disorderss everywhere of table 6
IgG | IgM | IgA | C3 | C4 | |
Experiment A | 970.78±16.50Ba | 64.16±5.28 | 12.40±1.25ab | 1.59±0.02a | 1.59±0.08 |
Experiment B | 980.25±15.35Ba | 64.01±5.06 | 12.14±1.42ab | 1.65±0.01ab | 1.55±0.05 |
Experiment C | 1052.71±16.21Aa | 67.56±5.88 | 13.70±1.40b | 1.76±0.02b | 1.60±0.04 |
Matched group | 871.10±15.24b | 61.02±4.03 | 10.94±1.43a | 1.50±0.01a | 1.51±0.05 |
Note:Same row difference lowercase letter indication difference significantly (p<0.05), different capitalizations represent that difference is extremely notable
(p<0.01)。
Table 6 shows that the serum immune globulin (IgG, IgA, IgM) of each experimental group and Complement C_3, the level of C4 are more right
All it is improved according to group, improves immunity.Experiment C groups are that NCG and Chinese herbal medicine combined effect are optimal.
When the addition of NCG and herbal composite is respectively the 0.01%, 0.03% (ratio of NCG and various Chinese herbal medicine
When as described in Example 1), the serum immune globulin (IgG, IgA, IgM) of experimental group and Complement C_3, the level of C4 and matched group
Compare, the conclusion of gained is consistent with above-mentioned conclusion.
Experiment shows that NCG and Chinese herbal medicine combination can improve poultry immune function, improve food conversion ratio.
Claims (10)
1. a kind of compositionss, the compositionss are by Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- carbamyl paddy ammonia
Acid composition;The mass ratio of the Radix Scutellariae, the Radix Astragali, Radix Paeoniae Alba, Flos Lonicerae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and N- carbamylglutamic acids is 10:15:
10:8:5:8:30.
2. a kind of forage mixture, is to be mixed to get basic feedstuff with the compositionss described in claim 1;The basic feedstuff
For perfect compound feed.
3. forage mixture according to claim 2, it is characterised in that:Compositionss and base described in the claim 1
This quality of the fodder ratio is 0.01-0.03:100.
4. forage mixture according to claim 3, it is characterised in that:Compositionss and base described in the claim 1
This quality of the fodder ratio is 0.01:100、0.02:100 or 0.03:100.
5. application of the compositionss described in claim 1 as additive in animal feed is prepared.
6. application of the compositionss described in claim 1 in the product for improving breeding performonce fo animals is prepared.
7. the compositionss described in claim 1 in the product for improving animal body immunocompetence or stress ability is prepared should
With.
8. application of the arbitrary described forage mixture of claim 2-4 in animal feed is prepared;
9. application of the arbitrary described forage mixture of claim 2-4 in the product for improving breeding performonce fo animals is prepared.
10. the arbitrary described forage mixture of claim 2-4 improves animal body immunocompetence or stress ability preparing
Application in product.
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CN104855704A (en) * | 2015-04-17 | 2015-08-26 | 邓全芳 | Duck feed additive and preparation method |
CN104920911B (en) * | 2015-07-10 | 2018-01-26 | 四川傲农生物科技有限公司 | A kind of feed addictive for improving reproduction performance of gestation sow and preparation method thereof |
CN106361857A (en) * | 2016-09-29 | 2017-02-01 | 林州亚太兴牧科技有限公司 | N-carbamylglutamic acid (NCG) composite for improving fur quality of rex rabbits and preparation method thereof |
CN109077189A (en) * | 2018-08-03 | 2018-12-25 | 河南大陆农牧技术股份有限公司 | A kind of composition of preventing miscarriage, the nutrient fodder for improving number born of sow and its application of raising number born of sow |
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Effective date of registration: 20200911 Address after: 456550, No. 8 Luban Road, Linzhou industrial agglomeration area, Henan, Anyang Patentee after: LINZHOU YATAI XINGMU TECHNOLOGY Co.,Ltd. Address before: 100193, No. 3, block C, 29 northeast Wang Nan Road, Beijing, Haidian District Patentee before: ANIMORE (BEIJING) SCIENCE & TECHNOLOGY Co.,Ltd. |