CN103494996A - Pharmaceutical composition for improving immunity of livestock and poultry and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for improving immunity of livestock and poultry and preparation method of pharmaceutical composition Download PDFInfo
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- CN103494996A CN103494996A CN201310456659.3A CN201310456659A CN103494996A CN 103494996 A CN103494996 A CN 103494996A CN 201310456659 A CN201310456659 A CN 201310456659A CN 103494996 A CN103494996 A CN 103494996A
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Abstract
The invention discloses a pharmaceutical composition for improving immunity of livestock and poultry and a preparation method of the pharmaceutical composition, belonging to the field of traditional Chinese medicines. The pharmaceutical composition is prepared from astragalus, Chinese yam and dried orange peel, active ingredients are respectively extracted in a water decoction mode according to different properties of the medicines and further is made into soluble powder. The pharmaceutical composition has the effects of enhancing immunity, replenishing qi to invigorate the spleen, tonifying blood, nourishing yin and regulating vital energy to promote appetite and is reasonable in formula, simple in process and low in production cost, the immunity of livestock and poultry can be effectively improved, and the disease resistance of the organism is enhanced.
Description
Technical field
The present invention relates to a kind of the have pharmaceutical composition of raising immunity of livestock and the preparation method of said composition, belong to the field of Chinese medicines.
Background technology
China is the big country of stock raising poultry, the fast development of aquaculture, the food of let us is abundanter, but deterioration and antibiotic abuse due to breeding environment, cause cultivated animals anti-adversity ability, immunocompetence, anti-stress ability to reduce, increasing subhealth state animal appears at each large plant.The decline of the production efficiency that the subhealth state animal brings, dead, disability rate raises, and causes aquaculture cost to strengthen, and this problem is perplexing the raiser always; Autoimmunity low, the antibiotics abuse that disease-susceptible humans is caused out, cause the enhancing of bacterial resistance bacterium property, makes the treatment difficulty of disease increase; Disease multiple season, some raiser is for fear of morbidity, tens of days even the several months admix antibiotic in feedstuff, its consequence directly has a strong impact on the safety of the edible brutish meat of the mankind and egg milk quality.
The problems referred to above make us again pay close attention to animal health, and seeking suitable prophylactic is veterinary's circle problem anxious to be resolved, and development and exploitation China Chinese herbal medicine resource improve immunity of livestock, have caused that domestic and international experts and scholars greatly pay attention to.Do the harmless herbal medicine of low toxicity, improve animal immunizing power, the resistance against diseases of enhancing body, just can make China's aquaculture go on the road of Sustainable Healthy Development.
For this reason, this area attempts to improve immunity of livestock with Chinese medicine, to solve the deficiencies in the prior art, still, up to the present, can improve the Chinese medicine of immunity of livestock, is all generally that Chinese medicine and Western medicine mix, and pure Chinese medicinal preparation research is less.
Summary of the invention
One object of the present invention be to provide a kind of and have replenishing QI to invigorate the spleen, the regulate the flow of vital energy effect of appetizing, for improving the pure Chinese medicine composition of immunity of livestock; The Radix Astragali is usingd in the present invention provides as principal agent that a kind of replenishing QI to invigorate the spleen, short treating period, therapeutic effect are good, the pure Chinese medicinal preparation of the raising immunity of livestock that has no side effect.
Another object of the present invention is to provide the preparation method of aforementioned pharmaceutical compositions.
The object of the present invention is achieved like this, according to the Chinese medicine and pharmacy theory, utilizes the property of medicine of medical herbs uniqueness, adopts the Radix Astragali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae according to certain compatibility requirement, through special process, processes.
Crude drug composition and the proportioning of preparation pharmaceutical composition of the present invention are as follows:
The Radix Astragali 2500～3500 weight portion Rhizoma Dioscoreae 400～700 weight portion Pericarpium Citri Reticulatae 200～400 weight portions
The crude drug of pharmaceutical composition of the present invention forms best proportioning for (by weight):
The Radix Astragali 3000 weight portion Rhizoma Dioscoreae 600 weight portion Pericarpium Citri Reticulatae 300 weight portions
Medicine of the present invention can be for soluble powder.
When preparing soluble powder, medicine of the present invention can adopt following method preparation: full side's decocting boils three times, adding for the first time 10～14 times of weight decoctings boils 1～5 hour, second and third time adds 8～12 times of weight decoctings at every turn and boils 1～4 hour, filter (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, (70～80 ℃ of concentrating under reduced pressure,-0.08Mpa) to relative density 1.12～1.15(60 ℃), filter (needing fine straining), spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
The preparation technology of medicine of the present invention can be: full side's decocting boils three times, adding for the first time 12 times of weight decoctings boils 2 hours, second and third time adds 10 times of weight decoctings at every turn boils 2 hours, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, (70～80 ℃ of concentrating under reduced pressure,-0.08Mpa) to relative density 1.12～1.15(60 ℃), filter (needing fine straining) spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
Pharmaceutical composition of the present invention is mainly used in improving immunity of livestock.Radix Astragali sweet in the mouth warm in nature, enter lung, return spleen channel, there is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, the toxin expelling evacuation of pus, the effects such as inducing diuresis to remove edema and granulation promoting, the Radix Astragali can the two-ways regulation body's immunity, the Promote immunity Cells Interferon Production, delaying cell aging, antibiotic and resisting fatigue, the adaptability of energy enhancing body and premunition etc.The effective constituent that mainly contains in the Radix Astragali is astragalus polysaccharides and a small amount of saponin, flavone etc., can enhancing human body immunity power, disease preventing and treating, anti-stress etc.In the present invention, Radix Astragali sweet in the mouth warm in nature, have the effect of tonifying Qi and lifting yang, replenishing QI to invigorate the spleen; Rhizoma Dioscoreae has the effect of strengthening the spleen and stomach, lung benefiting kidney, cures mainly weakness of the spleen and stomach, has loose bowels etc.; Pericarpium Citri Reticulatae has the effect of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Radix Astragali air making-up and spleen enlivening is monarch; It is minister that Rhizoma Dioscoreae helps Radix Astragali spleen reinforcing, stomach invigorating, antidiarrheal; With Pericarpium Citri Reticulatae, for making, anti-Radix Astragali amount is large and gastral cavity is swollen, the circulation of qi promoting intestinal stasis relieving.This three medicine share to have replenishing QI to invigorate the spleen, strengthens the potent of immunity, and the prescription advantages of simple is clinical remarkable for improving the livestock immunity effect.Compatibility between the present invention's three medicines is very crucial, is the essential condition that produces good efficacy.
The present invention is a kind of Chinese medicine composition that improves immunity of livestock, and it is little that research shows that the present invention has toxic and side effects, to improving immunity of livestock, good therapeutic effect is arranged, and effectively avoids the existence of subhealth state animal.The present invention by replenishing QI to invigorate the spleen, strengthen immune method for the treatment of, satisfied curative effect has been received in prevention and treatment to deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, the disease such as have loose bowels in clinical trial.Prescription advantages of simple of the present invention, processing technology is simple, and cost is low, and good effect.
The effect that the present invention's three medicines share generation has just reached the other drug various ingredients and has been used in combination the effect that can reach, and even will greatly be better than the effect that the other drug various ingredients is used in combination, although the crude drug that the present invention uses is few, curative effect is but very good.
The specific embodiment
Below with specific embodiment, illustrate again, but following embodiment only for being described, does not limit the present invention in the present invention.
Embodiment 1:
Prescription: Radix Astragali 3000g Rhizoma Dioscoreae 600g Pericarpium Citri Reticulatae 300g
Method for making: full side's decocting boils three times, adding for the first time 12 times of water gagings decocts 2 hours, second and third time adds 10 times of water gagings at every turn and decocts 2 hours, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, (70～80 ℃ of concentrating under reduced pressure,-0.08Mpa) to relative density 1.12～1.15(60 ℃), filter (needing fine straining) spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
Embodiment 2:
Prescription: Radix Astragali 600g Rhizoma Dioscoreae 150g Pericarpium Citri Reticulatae 80g
Method for making: full side's decocting boils three times, adding for the first time 60 times of water gagings decocts 1 hour, second and third time adds 50 times of water gagings at every turn and decocts 2 hours, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, (70～80 ℃ of concentrating under reduced pressure,-0.08Mpa) to relative density 1.12～1.15(60 ℃), filter (needing fine straining) spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
Embodiment 3:
Prescription: Radix Astragali 15kg Rhizoma Dioscoreae 3kg Pericarpium Citri Reticulatae 3kg
Method for making: full side's decocting boils three times, adding for the first time 60 times of water gagings decocts 4 hours, second and third time adds 50 times of water gagings at every turn and decocts 5 hours, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, (70～80 ℃ of concentrating under reduced pressure,-0.08Mpa) to relative density 1.12～1.15(60 ℃), filter (needing fine straining) spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
Embodiment 4:
10 of porklings, inappetence, spirit is slack, and rare water is just.Get the made soluble powder treatment of embodiment 1, scheme: mixed drink, every 100g this product is watered 1000kg, and 2 times on the one, administration 3 days.The rear observation of taking medicine, 10 equal appetite of porkling are recovered, without symptom of diarrhea, recovery from illness.
Embodiment 5:
One of pet dog (gold hair), lassitude suddenly, the lack of appetite asthenia, have loose bowels.Get the made soluble powder treatment of embodiment 2, scheme: spice is fed, a 5g, three times on the one, administration 3 days.The rear observation of taking medicine, spirit takes a turn for the better, and appetite is recovered, without symptom of diarrhea, recovery from illness.
Embodiment 6:
Laying hen field, Weifang, Shandong (totally 5000), carry out first three sky of immunity at avian influenza vaccine and give chemoprophylaxis.Chicken is divided into to two groups, gives the made soluble powder medication of the embodiment of the present invention 3, scheme for one group: mixed drink, every 100g is watered 200kg, continuous use 3 days; Give compound Radix Astragali polysaccharide (main component has the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi) for two groups, Qingdao Zhong Ren pharmaceutcal corporation, Ltd produces.Scheme: mixed drink, every 1kg is watered 5000kg, successive administration 3 days.Administration in 3 days is carried out the avian influenza vaccine immunity after finishing, and observes the incidence at this chicken house of bird flu high-incidence season.Add up respectively the incidence of two groups, in Table 1.
The incidence of each group of table 1
| Group | Sum | The morbidity number | Death toll | Sickness rate |
| Medicine of the present invention | 2500 | 113 | 22 | 4.52% |
| Matched group | 2500 | 874 | 355 | 34.96% |
Visible, the sickness rate of medicine group of the present invention is than the remarkable minimizing of matched group.Illustrate that prophylactic played the effect that strengthens immune effect.
Embodiment 7:
4432 of live pigs are raised in 2009 in pig farm, Yantai, Shandong, and wherein male and female is 280, and suckling pig has 1344, and the child care piglet has 844, and growing and fattening pigs have 1172.Since May, poultry is main always thinks that oneself pig appetite is bad, poor growth, and farrowing rate and suckling pig survival rate be corresponding having a declining tendency all, and sow is had difficult labour, the product still birth rate all should have the trend of rising mutually.The sow main manifestations is that eye conjunctiva flushing, fur are slightly random; Big porker becomes thin, feces is thinning etc.Then full group pig in 2010 is used product example 3 of the present invention, by corresponding symptom in rear swinery, has all disappeared, and the production achievement also is significantly improved.Illustrate that the subhealth state that product of the present invention improves the immunity of pig and improves pig has had effect really, with after have no side effect, also drug residue free, and cost is low, is the preparation that effectively strengthens Swinery immunity power.
Embodiment 8:
Shandong Province duckery, raise laying ducks 15285 plumages of 248 ages in days, laying rate 63%, lay eggs individual less than normal, since opening product, the laying ducks inappetence, average daily egg production obviously descends, and loose and watery stool is soft, feather is fluffy and disorderly, whole duck group's health status is bad, and in order to improve this situation, poultry is main selects suitable medicine to improve the full duck group's of factory health status in advance.No. 1 duck shed is used product example 1 of the present invention to carry out medication, scheme: mixed drink, and every 100g is watered 400 jin, continuous use 7 days; No. 2 duck shed is used removing summer-heat mixture (main component has Flos Lonicerae, Radix Scrophulariae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae etc.) to carry out medication, and sky, Jinan poly-animal husbandry Science and Technology Ltd. produces, scheme: mixed drink, and every 2.5mL is watered 1L, continuous use 7 days; No. 3 duck shed is used antipyretic and antitoxic powder (main component astragalus polysaccharides, Gypsum Fibrosum, Radix Rehmanniae, Cornu Bubali, Rhizoma Coptidis) to carry out medication, and Jiangsu south agriculture high-tech animal pharmaceutical estate company limited is produced, and scheme: mixed drink, every 100g is watered 400 jin, continuous use 7 days.
After administration, symptom is judged:
Cure: duck group appetite recovers normal, and feces is normal, and egg production obviously increases, and feather is ruddy, and growth evenly.
Effectively: duck group appetite recovers normal, and feces is normal, and growth evenly.
Add up respectively two groups of effects, in Table 2.
The efficacy result of each medication group of table 2
| Group | Sum | Morbidity duck group | Cure number | Significant figure | Total effective rate |
| No. 1 duck shed | 5200 | 3650 | 3482 | 58 | 96.98% |
| No. 2 duck sheds | 5000 | 3210 | 2598 | 212 | 87.53% |
| No. 3 duck sheds | 5085 | 3252 | 2414 | 245 | 81.76% |
Visible, medicine group of the present invention is evident in efficacy than matched group.Find after using that explanation product of the present invention can effectively improve duck group's immunity.
Show that through a plurality of healing cases medicine of the present invention can effectively improve immunity of livestock, strengthen the resistance against diseases of poultry body, rather than because the case that the difference of individual and therapeutic scheme causes.Medicine of the present invention has good application and popularization value.
Claims (5)
1. a pharmaceutical composition that improves immunity of livestock, is characterized in that, this pharmaceutical composition comprises following raw material medicaments:
The Radix Astragali 2500～3500 weight portion Rhizoma Dioscoreae 400～700 weight portion Pericarpium Citri Reticulatae 200～400 weight portions.
2. the pharmaceutical composition of raising immunity of livestock according to claim 1, is characterized in that, said composition comprises following raw material medicaments:
The Radix Astragali 3000 weight portion Rhizoma Dioscoreae 600 weight portion Pericarpium Citri Reticulatae 300 weight portions.
3. the pharmaceutical composition of raising immunity of livestock according to claim 1 and 2, is characterized in that, said composition can be made into soluble powder.
4. the preparation method of the pharmaceutical composition of raising immunity of livestock according to claim 1 and 2 is characterized in that comprising following steps:
Full side's decocting boils three times, adding for the first time 10～14 times of water gagings decocts 1～5 hour, second and third time adds 8～12 times of water gagings at every turn and decocts 1～4 hour, filters merging filtrate, at 70～80 ℃, relative density 1.12～1.15 o'clock while under-0.08Mpa condition, being evaporated to 60 ℃, filter spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
5. the preparation method of the pharmaceutical composition of raising immunity of livestock according to claim 4 is characterized in that comprising following steps:
Full side's decocting boils three times, adding for the first time 12 times of water gagings decocts 2 hours, second and third time adds 10 times of water gagings at every turn and decocts 2 hours, filters merging filtrate, at 70～80 ℃, relative density 1.12～1.15 o'clock while under-0.08Mpa condition, being evaporated to 60 ℃, filter spray drying, it is loose that the gained dry extract is directly made extractum, obtains.
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Cited By (4)
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| CN104938837A (en) * | 2015-06-15 | 2015-09-30 | 赖亚从 | Pig feed traditional Chinese medicine additive, preparation method and pig feed adopting pig feed traditional Chinese medicine additive |
| CN104982712A (en) * | 2015-06-15 | 2015-10-21 | 赖亚从 | Chinese herb additive in pig feed, making method and pig feed |
| CN106109831A (en) * | 2016-08-16 | 2016-11-16 | 陈艳 | A kind of veterinary drug that can improve immunity of livestock |
| CN109939190A (en) * | 2017-12-20 | 2019-06-28 | 台安鸿灏农牧种养有限责任公司 | A kind of Chinese medicine is the mixed fodder formula of raw material |
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Cited By (4)
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|---|---|---|---|---|
| CN104938837A (en) * | 2015-06-15 | 2015-09-30 | 赖亚从 | Pig feed traditional Chinese medicine additive, preparation method and pig feed adopting pig feed traditional Chinese medicine additive |
| CN104982712A (en) * | 2015-06-15 | 2015-10-21 | 赖亚从 | Chinese herb additive in pig feed, making method and pig feed |
| CN106109831A (en) * | 2016-08-16 | 2016-11-16 | 陈艳 | A kind of veterinary drug that can improve immunity of livestock |
| CN109939190A (en) * | 2017-12-20 | 2019-06-28 | 台安鸿灏农牧种养有限责任公司 | A kind of Chinese medicine is the mixed fodder formula of raw material |
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| CN103494996B (en) | 2016-03-23 |
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