CN103494996B - A kind of pharmaceutical composition improving immunity of livestock and preparation method thereof - Google Patents
A kind of pharmaceutical composition improving immunity of livestock and preparation method thereof Download PDFInfo
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- CN103494996B CN103494996B CN201310456659.3A CN201310456659A CN103494996B CN 103494996 B CN103494996 B CN 103494996B CN 201310456659 A CN201310456659 A CN 201310456659A CN 103494996 B CN103494996 B CN 103494996B
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Abstract
The invention discloses a kind of pharmaceutical composition improving immunity of livestock and preparation method thereof, belong to the field of Chinese medicines.This pharmaceutical composition is the crude drug such as the Radix Astragali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, adopts the mode effective component extracting of soak by water respectively, and make soluble powder according to medicine heterogeneity.This pharmaceutical composition has the effect strengthening immunity, replenishing QI to invigorate the spleen, YIN nourishing of enriching blood, appetizing of regulating the flow of vital energy, and reasonable recipe, technique is simple, production cost is low, effectively can improve the immunity of poultry, the resistance against diseases of enhancing body.
Description
Technical field
The present invention relates to a kind of have improve the pharmaceutical composition of immunity of livestock and the preparation method of said composition, belong to the field of Chinese medicines.
Background technology
China is the big country of stock raising poultry, the fast development of aquaculture, the food of let us is abundanter, but due to deterioration and the antibiotic abuse of breeding environment, cause cultivated animals anti-adversity ability, immunocompetence, anti-stress ability to reduce, increasing subhealth state animal appears at Ge great plant.The decline of the production efficiency that subhealth state animal brings, dead, disability rate raises, and cause aquaculture cost to strengthen, this problem annoyings raiser always; Autoimmunity low, to the antibiotics abuse that disease-susceptible humans causes out, causes bacterial resistance bacterium property to strengthen, the treatment difficulty of disease is increased; Disease multiple season, some raiser is in order to avoid morbidity, and tens of day, even the several months admixed antibiotic in feedstuff, and its consequence directly has a strong impact on the safety that the mankind eat brutish meat and egg milk quality.
The problems referred to above make us again pay close attention to animal health, and seeking suitable prophylactic is veterinary's circle problem anxious to be resolved, and Study and Development utilizes China's Chinese herbal medicine resource to improve immunity of livestock, has caused domestic and international experts and scholars greatly to pay attention to.Do the herbal medicine that low toxicity is harmless, improve animal immunizing power, the resistance against diseases of enhancing body, Cai Nengshi China aquaculture goes on the road of Sustainable Healthy Development.
For this reason, this area attempts to improve immunity of livestock with Chinese medicine, and to solve the deficiencies in the prior art, but up to the present, can improve the Chinese medicine of immunity of livestock, be all generally Chinese medicine and Western medicine mixing, pure Chinese medicinal preparation research is less.
Summary of the invention
One object of the present invention is to provide a kind of and has replenishing QI to invigorate the spleen, the effect of appetizing of regulating the flow of vital energy, for improving the pure Chinese medicine composition of immunity of livestock; The present invention provides the pure Chinese medicinal preparation of raising immunity of livestock that a kind of replenishing QI to invigorate the spleen, short treating period, therapeutic effect are good, have no side effect using the Radix Astragali as principal agent.
Another object of the present invention is the preparation method providing aforementioned pharmaceutical compositions.
The object of the present invention is achieved like this, theoretical according to Chinese medicine and pharmacy, utilizes the property of medicine of medical herbs uniqueness, adopts the Radix Astragali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae according to certain compatibility requirement, process through special process.
Crude drug composition and the proportioning of preparing pharmaceutical composition of the present invention are as follows:
The Radix Astragali 2500 ~ 3500 weight portion Rhizoma Dioscoreae 400 ~ 700 weight portion Pericarpium Citri Reticulatae 200 ~ 400 weight portion
The crude drug composition optimum proportioning of pharmaceutical composition of the present invention is (by weight):
The Radix Astragali 3000 weight portion Rhizoma Dioscoreae 600 weight portion Pericarpium Citri Reticulatae 300 weight portion
Medicine of the present invention may be used for soluble powder.
When preparing soluble powder, medicine of the present invention can be adopted and prepare with the following method: full side's soak by water three times, first time adds 10 ~ 14 times of weight water and decocts 1 ~ 5 hour, second and third time adds 8 ~ 12 times of weight water at every turn and decocts 1 ~ 4 hour, filter (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, concentrating under reduced pressure (70 ~ 80 DEG C,-0.08Mpa) to relative density 1.12 ~ 1.15(60 DEG C), filter (needing fine straining), spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
The preparation technology of medicine of the present invention can be: full side's soak by water three times, first time adds 12 times of weight water and decocts 2 hours, second and third time adds 10 times of weight water at every turn and decocts 2 hours, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, concentrating under reduced pressure (70 ~ 80 DEG C,-0.08Mpa) to relative density 1.12 ~ 1.15(60 DEG C), filter (needing fine straining), spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
Pharmaceutical composition of the present invention is mainly used in improving immunity of livestock.Radix Astragali sweet in the mouth warm in nature, enter lung, return spleen channel, there is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, toxin expelling evacuation of pus, the effect such as inducing diuresis to remove edema and granulation promoting, the Radix Astragali can two-ways regulation body's immunity, Promote immunity Cells Interferon Production, delaying cell aging, antibacterial and resisting fatigue, the adaptability of energy enhancing body and premunition etc.The effective constituent that mainly contains in the Radix Astragali is astragalus polysaccharides and a small amount of saponin, flavone etc., can enhancing human body immunity power, disease preventing and treating, anti-stress etc.In the present invention, Radix Astragali sweet in the mouth warm in nature, has effect of tonifying Qi and lifting yang, replenishing QI to invigorate the spleen; Rhizoma Dioscoreae has the effect of strengthening the spleen and stomach, lung benefiting kidney, cures mainly weakness of the spleen and stomach, has loose bowels; Pericarpium Citri Reticulatae has the effect of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Radix Astragali air making-up and spleen enlivening is monarch; Rhizoma Dioscoreae helps Radix Astragali spleen reinforcing, stomach invigorating, antidiarrheal to be minister; With Pericarpium Citri Reticulatae for making, anti-Radix Astragali amount is large and gastral cavity is swollen, circulation of qi promoting intestinal stasis relieving.This three medicine share have replenishing QI to invigorate the spleen, strengthen immunity potent, prescription advantages of simple, clinical in improving livestock immunity Be very effective.Compatibility between the present invention three medicine is very crucial, is the essential condition producing good efficacy.
The present invention is a kind of Chinese medicine composition improving immunity of livestock, and it is little that research shows that the present invention has toxic and side effects, has good therapeutic effect, effectively avoid the existence of subhealth state animal to raising immunity of livestock.The present invention, by replenishing QI to invigorate the spleen, the method for the treatment of strengthening immunity, have received satisfied curative effect to the prevention and therapy of deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, the disease such as to have loose bowels in clinical trial.Prescription advantages of simple of the present invention, processing technology is simple, and cost is low, and good effect.
The effect that the present invention three medicine share generation just reaches other drug various ingredients and combinationally uses the effect that can reach, and even greatly will be better than the effect that other drug various ingredients combinationally uses, although the crude drug that the present invention uses is few, curative effect is but very good.
Detailed description of the invention
Illustrate with specific embodiment more below, but following embodiment does not only limit the present invention for illustration of the present invention.
Embodiment 1:
Prescription: Radix Astragali 3000g Rhizoma Dioscoreae 600g Pericarpium Citri Reticulatae 300g
Method for making: full side's soak by water three times, first time adds 12 times amount soak by water 2 hours, second and third time adds 10 times amount soak by water 2 hours at every turn, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, concentrating under reduced pressure (70 ~ 80 DEG C,-0.08Mpa) to relative density 1.12 ~ 1.15(60 DEG C), filter (needing fine straining), spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
Embodiment 2:
Prescription: Radix Astragali 600g Rhizoma Dioscoreae 150g Pericarpium Citri Reticulatae 80g
Method for making: full side's soak by water three times, first time adds 60 times amount soak by water 1 hour, second and third time adds 50 times amount soak by water 2 hours at every turn, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, concentrating under reduced pressure (70 ~ 80 DEG C,-0.08Mpa) to relative density 1.12 ~ 1.15(60 DEG C), filter (needing fine straining), spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
Embodiment 3:
Prescription: Radix Astragali 15kg Rhizoma Dioscoreae 3kg Pericarpium Citri Reticulatae 3kg
Method for making: full side's soak by water three times, first time adds 60 times amount soak by water 4 hours, second and third time adds 50 times amount soak by water 5 hours at every turn, filters (common tank band filter screen or add layer gunnysack strengthen), merging filtrate, concentrating under reduced pressure (70 ~ 80 DEG C,-0.08Mpa) to relative density 1.12 ~ 1.15(60 DEG C), filter (needing fine straining), spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
Embodiment 4:
Porkling 10, inappetence, spirit is slack, rare aquiform stool.The made soluble powder treatment of Example 1, scheme: mixed drink, every 100g this product is watered 1000kg, 2 times on the one, administration 3 days.Take observation post administration, 10 equal appetite of porkling are recovered, without symptom of diarrhea, and recovery from illness.
Embodiment 5:
Pet dog (golden hair) one, lassitude suddenly, lack of appetite asthenia, has loose bowels.The made soluble powder treatment of Example 2, scheme: spice is fed, a 5g, three times on the one, administration 3 days.Take observation post administration, spirit takes a turn for the better, and appetite is recovered, without symptom of diarrhea, and recovery from illness.
Embodiment 6:
Laying hen field, Weifang, Shandong (totally 5000), carries out first three sky of immunity at avian influenza vaccine and gives chemoprophylaxis.Chicken is divided into two groups, gives the made soluble powder medication of the embodiment of the present invention 3, scheme for one group: mixed drink, every 100g is watered 200kg, continuous use 3 days; Give compound Radix Astragali polysaccharide (main component has the Radix Astragali, Herba Epimedii, Fructus Ligustri Lucidi) for two groups, Qingdao Zhongren Pharmaceutical Co.Ltd. produces.Scheme: mixed drink, every 1kg is watered 5000kg, successive administration 3 days.Carry out avian influenza vaccine immunity after administration in 3 days terminates, and observe the incidence at this chicken house of bird flu high-incidence season.Add up the incidence of two groups respectively, in table 1.
The incidence that table 1 is respectively organized
| Group | Sum | Morbidity number | Death toll | Sickness rate |
| Medicine of the present invention | 2500 | 113 | 22 | 4.52% |
| Matched group | 2500 | 874 | 355 | 34.96% |
Visible, the sickness rate of medicine group of the present invention is compared with the remarkable minimizing of matched group.Illustrate that prophylactic serves the effect strengthening immune effect.
Embodiment 7:
Live pig 4432, wherein male and female 280 are raised in 2009 in pig farm, Yantai, Shandong, and suckling pig has 1344, and child care piglet has 844, and growing and fattening pigs have 1172.Since May, poultry is main always thinks that oneself pig appetite is bad, poor growth, and farrowing rate is all corresponding with suckling pig survival rate to have a declining tendency, and sow is had difficult labour, produces the trend that still birth rate should have rising all mutually.Sow main manifestations is that eye conjunctiva flushing, fur are slightly random; Big porker becomes thin, feces is thinning.Then full group pig in 2010 uses product example 3 of the present invention, and all disappear by symptom corresponding in rear swinery, Growth Results is also significantly improved.Illustrate that the immunity that product of the present invention improves pig and the subhealth state improving pig have had effect really, with after have no side effect, also drug residue free, and cost is low, is the preparation effectively strengthening Swinery immunity power.
Embodiment 8:
Duckery of Shandong Province, raise laying ducks 15285 plumage of 248 ages in days, laying rate 63%, lay eggs individual less than normal, since opening product, laying ducks inappetence, average daily egg production obviously declines, and loose and watery stool is soft, feather is fluffy and disorderly, the health status of whole duck group is bad, and in order to improve this situation, poultry is main selects suitable medicine to improve the health status of full factory duck group in advance.No. 1 duck shed uses product example 1 of the present invention to carry out medication, scheme: mixed drink, and every 100g is watered 400 jin, continuous use 7 days; No. 2 duck sheds use removing summer-heat mixture (main component has Flos Lonicerae, Radix Scrophulariae, Radix Scutellariae, Radix Isatidis, Fructus Forsythiae etc.) to carry out medication, and Jinan Tian Ju animal husbandry Science and Technology Ltd. produces, scheme: mixed drink, and every 2.5mL is watered 1L, continuous use 7 days; No. 3 duck sheds use antipyretic and antitoxic powder (main component astragalus polysaccharides, Gypsum Fibrosum, Radix Rehmanniae, Cornu Bubali, Rhizoma Coptidis) to carry out medication, and Jiangsu Nannong Hi-Tech Animal Medicine Co., Ltd. produces, scheme: mixed drink, every 100g is watered 400 jin, continuous use 7 days.
After administration, symptom judges:
Cure: duck group appetite recovers normal, and feces is normal, and egg production obviously increases, and feather is ruddy, growth evenly.
Effective: duck group appetite recovers normal, and feces is normal, growth evenly.
Add up two groups of effects respectively, in table 2.
The efficacy result of each medication group of table 2
| Group | Sum | Morbidity duck group | Cure number | Significant figure | Total effective rate |
| No. 1 duck shed | 5200 | 3650 | 3482 | 58 | 96.98% |
| No. 2 duck sheds | 5000 | 3210 | 2598 | 212 | 87.53% |
| No. 3 duck sheds | 5085 | 3252 | 2414 | 245 | 81.76% |
Visible, evident in efficacy compared with matched group of medicine group of the present invention.Rear discovery is used to illustrate that product of the present invention effectively can improve the immunity of duck group.
Show that medicine of the present invention effectively can improve immunity of livestock through multiple healing case, strengthen the resistance against diseases of poultry body, instead of because of the case that difference that is individual and therapeutic scheme causes.Medicine of the present invention has good application and popularization value.
Claims (5)
1. improve a pharmaceutical composition for immunity of livestock, it is characterized in that, the crude drug of this pharmaceutical composition is:
The Radix Astragali 2500 ~ 3500 weight portion, Rhizoma Dioscoreae 400 ~ 700 weight portion, Pericarpium Citri Reticulatae 200 ~ 400 weight portion.
2. the pharmaceutical composition of raising immunity of livestock according to claim 1, is characterized in that, the crude drug of this pharmaceutical composition is:
The Radix Astragali 3000 weight portion, Rhizoma Dioscoreae 600 weight portion, Pericarpium Citri Reticulatae 300 weight portion.
3. the pharmaceutical composition of raising immunity of livestock according to claim 1 and 2, is characterized in that, said composition can be made into soluble powder.
4. the preparation method of the pharmaceutical composition of raising immunity of livestock according to claim 1 and 2, is characterized in that comprising following steps:
Full side's soak by water three times, first time adds 10 ~ 14 times amount soak by water 1 ~ 5 hour, second and third time adds 8 ~ 12 times amount soak by water 1 ~ 4 hour at every turn, filters, merging filtrate, at 70 ~ 80 DEG C, when being evaporated to 60 DEG C under-0.08Mpa condition relative density 1.12 ~ 1.15 time, filter, spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
5. the preparation method of the pharmaceutical composition of raising immunity of livestock according to claim 4, is characterized in that comprising following steps:
Full side's soak by water three times, first time adds 12 times amount soak by water 2 hours, second and third time adds 10 times amount soak by water 2 hours at every turn, filters, merging filtrate, at 70 ~ 80 DEG C, when being evaporated to 60 DEG C under-0.08Mpa condition relative density 1.12 ~ 1.15 time, filter, spraying dry, gained dry extract is directly made extractum and is fallen apart, and to obtain final product.
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| CN104938837A (en) * | 2015-06-15 | 2015-09-30 | 赖亚从 | Pig feed traditional Chinese medicine additive, preparation method and pig feed adopting pig feed traditional Chinese medicine additive |
| CN104982712A (en) * | 2015-06-15 | 2015-10-21 | 赖亚从 | Chinese herb additive in pig feed, making method and pig feed |
| CN106109831A (en) * | 2016-08-16 | 2016-11-16 | 陈艳 | A kind of veterinary drug that can improve immunity of livestock |
| CN109939190A (en) * | 2017-12-20 | 2019-06-28 | 台安鸿灏农牧种养有限责任公司 | A kind of Chinese medicine is the mixed fodder formula of raw material |
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| CN1330877A (en) * | 2000-06-23 | 2002-01-16 | 袁野 | Chinese-medicinal additive of feed |
| CN1589645A (en) * | 2003-09-01 | 2005-03-09 | 郑州博凯医药科技有限公司 | Animal feed additive capable of promoting growth and increasing lean meat rate |
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| CN1261138C (en) * | 2003-11-21 | 2006-06-28 | 广州康和药业有限公司 | Medicine for increasing immunocompetence of children and its preparing process |
| CN103083510A (en) * | 2011-11-03 | 2013-05-08 | 青岛康地恩药业股份有限公司 | Chinese medicinal oral liquid for improving poultry immune function and its preparation method |
| CN103283959A (en) * | 2013-01-29 | 2013-09-11 | 广州格拉姆生物科技有限公司 | Chinese herbal ultra-fine powder feed additive and its application in culture |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1330877A (en) * | 2000-06-23 | 2002-01-16 | 袁野 | Chinese-medicinal additive of feed |
| CN1589645A (en) * | 2003-09-01 | 2005-03-09 | 郑州博凯医药科技有限公司 | Animal feed additive capable of promoting growth and increasing lean meat rate |
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