CN103283959A - Chinese herbal ultra-fine powder feed additive and its application in culture - Google Patents
Chinese herbal ultra-fine powder feed additive and its application in culture Download PDFInfo
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Abstract
The invention relates to a preparation method of a Chinese herbal ultra-fine powder feed additive and its application in culture. The composition is prepared from Astragalus, Dioscorea opposita Thunb, hawthorn, Radix Codonopsis, Radix Bupleuri, liquorice, dried orange peel and other drugs according to certain proportion. The steps include: firstly, cutting Astragalus, Dioscorea opposita Thunb, hawthorn, Radix Codonopsis, Radix Bupleuri, liquorice, and dried orange peel into segments respectively; then, respectively crushing the segments of Astragalus, Dioscorea opposita Thunb, hawthorn, Radix Codonopsis, Radix Bupleuri, liquorice and dried orange peel; thirdly, respectively taking Astragalus powder, Dioscorea opposita Thunb powder, hawthorn powder, Radix Codonopsis powder, Radix Bupleuri powder, liquorice powder and dried orange peel powder according to certain proportion, and fully mixing them; and fourth, subjecting the mixture obtained in the last step to superfine grinding treatment to an average particle size of 30 micrometers, then carrying out split packaging, sealing and preservation. Being reasonable, the prescription has definite effects and no toxic or side effect, and active ingredients can be release completely and take effect rapidly. The method is easy to implement, and is suitable for mass production. The Chinese herbal ultra-fine powder feed additive can promote animals' absorption of nutrients in feed, improve the intestinal environment, enhance immunity and disease resistance of organisms, and improve growth performance.
Description
Technical field
The present invention relates to the animal feed additive technical field, a kind of Chinese herbal medicine ultra micro powder feed additive for pig industry specifically also relates to the preparation method of this feed addictive simultaneously.
Background technology
Chinese herbal feed additive has nutrition and medicinal function concurrently, compares with other feed addictive, have toxic and side effect little, have no drug resistance, residual advantage such as low.At present research is more, and Chinese herbal medicines such as hawthorn, the Radix Astragali, the red sage root, Radix Codonopsis, tangerine peel, dried orange peel, Radix Angelicae Sinensis, pine needle, its mechanism of action are arranged mainly is to promote the absorption of nutriment and utilization, enhancing immunity of organisms, antibiotic, anti-ly stress, improve intestinal microecology etc.Chinese herbal medicine is as animal feed additive, because its source is wide, cost is low, and the disease-resistant growth-promoting effect significantly becomes one of focus of animal feed additive research and development.But the Chinese herbal feed additive of putting on market now mostly is traditional powder, and its production technology falls behind, process coarse simple, kind is single, and particularly using dosage is bigger than normal, usually 2%～3%, even reach 6%, the cost height, waste is serious, presses for development novel form and new technology, wherein, ultrafine preparation just can significantly reduce drug dose under identical result of use.Chinese herbal medicine ultra micro powder is less as the application report of feed addictive in Animal nutrition.According to Chinese veterinarian's theory, be that main ingredient is made compound ultra micro powder feed additive with the Radix Astragali, Chinese yam rhizome, hawthorn etc., successfully be used for the child care piglet, and have tangible disease-resistant growth-promoting effect.
The Chinese herbal medicine ultrafine preparation can greatly increase surface area and the sporoderm-broken rate of drug particles, significantly increases the release of Chinese herbal medicine effective ingredients.Conventional relatively powder, the effective ingredient that Chinese herbal medicine ultra micro powder feed additive discharges in animal gastrointestinal tract significantly increases, when reaching identical result of use, can significantly reduce the medicine addition, reduce cost, also can save the use amount of Chinese herbal medicine, alleviate the situation of current Chinese herbal medicine resource anxiety, can also avoid medicinal herb components to the influence of forage compounding and other nutriment.After adding the ultra micro powder in the daily ration, ileum chyme total amino acid content significantly is lower than control group, the serum total amino acid is significantly higher than control group, illustrate that this Chinese herbal medicine ultra micro powder can strengthen digestion and the amino acid whose absorption of protein, may be because Chinese herbal medicine, the effect that promotes the glandula digestive secretion, increases gastric juice enzyme activity is arranged as hawthorn etc., thereby promote that forage protein is degraded to free amino acid; The Radix Astragali, Chinese yam rhizome, Radix Codonopsis, hawthorn, radix bupleuri, Radix Glycyrrhizae and dried orange peel etc. in the Chinese herbal medicine ultra micro powder itself contain rich in protein and amino acid, can increase amino acid whose absorption by increasing the amino acid whose content of intestines and stomach, thereby increase the content of serum amino acid.In addition, thereby also increase epithelium of intestinal mucosa to the content of the absorption increase serum amino acid of enteric cavity free amino acid with Chinese herbal medicine, and it is relevant to have reduced the amino acid whose content of terminal ileum chyme.
Utilizing advanced superfine communication technique, on the basis of traditional classical prescription, after the clinical symptoms screening and being improved, develop natural drug ultrafine preparation for animals, is the revolution to original important preparation manufacture.Such preparation is compared with traditional Chinese medicine powder, has characteristics such as the active ingredient rate of release is fast, bioavailability is high, clinical application effect is remarkable, unit kg body weight consumption is few.Utilize existing advanced technology, carry out Chinese herbal feed additive research energetically, not only can solve the antibiotic residue problem of long-term puzzlement animal husbandry development, boost productivity, reduce environmental pollution, develop green animal husbandry, satisfy the people's food security demand; And the gap that can dwindle China's animal husbandry and developed country, strengthen China's livestock products in the competitiveness of international market, have important economic implications and social effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese herb compound ultra micro powder feed additive, prescription is reasonable, and active ingredient is very complete, and addition is little, onset is rapid, and is effective, can prevent and treat live pig diarrhoea effectively, significantly improve growth performance, improve survival rate, reduce feedstuff-meat ratio.
Another object of the present invention has been to provide a kind of method for preparing Chinese herb compound ultra micro powder feed additive, and is simple to operate, applicable to large-scale production with promote the use of.
In order to realize above-mentioned task, the present invention adopts following technical measures:
A kind of Chinese herbal medicine ultra micro powder feed additive has the Radix Astragali, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae, dried orange peel formulated by a certain percentage, and this additive is made up of the medicine material of following mass percent:
Medicine material %
The Radix Astragali 20 ~ 30
Chinese yam rhizome 15 ~ 25
Hawthorn 15 ~ 25
Radix Codonopsis 5 ~ 15
Radix bupleuri 5 ~ 15
Radix Glycyrrhizae 5 ~ 15
Dried orange peel 5 ~ 15
Its preferred proportion is:
Medicine material %
The Radix Astragali 22 ~ 28
Chinese yam rhizome 18 ~ 22
Hawthorn 18 ~ 24
Radix Codonopsis 8 ~ 13
Radix bupleuri 6 ~ 12
Radix Glycyrrhizae 6 ~ 12
Dried orange peel 5 ~ 10
Utilize effects such as its tranquilizing and allaying excitement, invigorating the spleen tonifying Qi, nourishing and strengthening vital, promoting blood circulation and food digesting stomach fortifying, improve immunity function of animal, improve body anti-oxidation function and intestinal microecology balance, reduce the generation of diseases such as diarrhoea, promote growth, improve efficiency of feed utilization, reduce feedstuff-meat ratio.
A kind of method for preparing Chinese herbal medicine ultra micro powder feed additive the steps include: at first with the segment (2 ~ 4cm) respectively of the Radix Astragali, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel; Secondly the Radix Astragali after the segment, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel are pulverized respectively in (150 ~ 160 order); The 3rd is to get certain proportion of astragalus, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel pulvis fully to mix; The 4th is further said mixture to be made ultramicro grinding to handle, and making average grain diameter is 30 μ m, and sealing is preserved after the packing.
Chinese herbal medicine ultra micro powder feed additive of the present invention has the following advantages and effect: Chinese herbal medicine ultra micro powder can be regulated body immune system and significantly improve immunologic function from tissue, organ, cell and molecular level; Significantly improve anti-oxidation function, adaptability and the tolerance of animal body; Significantly improve animal body intestinal microecology, regulate the gut flora balance, effectively control diarrhoea; Can significantly improve digestion and absorption function, promote growth, improve efficiency of feed utilization, reduce feedstuff-meat ratio.
The present invention fills a prescription rationally, active ingredient discharges fully, addition is little, onset is rapid, definite effect, have no side effect, and method is easy to implement, applicable to large-scale production with promote the use of.
The specific embodiment
The preparation method of 1 one kinds of Chinese herbal medicine ultra micros of embodiment powder feed additive
Its prescription of a kind of Chinese herbal medicine ultra micro powder feed additive following (mass percent %):
External pharmacological action screening: filtering out the stronger Chinese herbal medicine of a few flavor effects from existing anti-stress medicine is research object, measures it to the external inhibitory action of a few boar pathogenic bacteria; Adopt the external generation hydroxy radical of ascorbic acid system method, measure the effect that it removes hydroxy radical; Utilize cell culture technology simultaneously, measure it to the influence of piglet PBLC activity.
The preparation of Chinese herbal ultra-fine powder feed addictive: overall merit respectively is subjected to the effects such as external antibacterial, anti-oxidant and immune enhancing of reagent thing, filtering out the yellow qi of obvious results, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel is the component medicine, and it is carried out scientific composition.A kind of preparation method of Chinese herbal medicine ultra micro powder feed additive the steps include: at first with the segment (2 ~ 4cm) respectively of the Radix Astragali, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel; Secondly the Radix Astragali after the segment, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel are pulverized respectively in (150 ~ 160 order); The 3rd is to get certain proportion of astragalus, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel pulvis fully to mix; The 4th is further said mixture to be made ultramicro grinding to handle, and making average grain diameter is 30 μ m, and sealing is preserved after the packing.Measure the content of main active such as its polysaccharide, flavones, organic acid, amino acid and alkaloid simultaneously, as one of quality control index.
2 one kinds of Chinese herbal medicine ultra micros of embodiment powder feed additive promotes the application of child care pig growth
1 experimental design
Be the influence of checking Chinese herbal medicine ultra micro powder feed additive to child care pig growth performance and immunity, the design of single-factor completely random is adopted in test, 240 the wean age in days that is in a good state of health is close with physique, that male and female is identical assorted piglets of (long * big) binary are divided into an experimental group and a control group, every group of 120 repetitions at random.Each is organized the daily ration structure and sees Table 1.
Table 1 daily ration structure
2 feedings and managements
Test is carried out in same child care pig house, and piglet is adopted the child care of high bed, and piglet carries out thorough disinfection with the child care pig house before advancing house, and cleans the automatic hopper of piglet, piglet free choice feeding and drinking-water.After test pig is entered the hurdle, carry out 3d and raise the phase in advance, 32d just raises the phase.When formal test begins, test pig is claimed quality and carries out homogeneity test indivedual the adjustment makes group difference not remarkable, just changes over to then and tries the phase again on an empty stomach.Duration of test requires to carry out production management according to the daily management on pig farm, and carries out routine immunization and expelling parasite.Carry out the record of related datas such as food consumption in the process of the test.
Detection method and index
Weigh and ramming material the next day in each experiment day, calculate average daily gain (average daily weight, ADG), average daily ingestion amount (average daily feed intake, ADFI) and feedstuff-meat ratio (Feed:Gain).
Average daily gain (Kg/ days)=total augment weight sum (Kg)/experiment fate
Average daily ingestion amount (the Kg/ previous day)=total feed consumption rate (Kg)/all survival pig's heads are counted sum (previous day)
Consume the gain in weight of forage volume/contemporaneity body weight feedstuff-meat ratio=a certain period
4 statistical analyses
Be infrastest unit with every pig, indexs employing SPSS softwares such as average initial weight, average end weight, average weight gain, average daily gain carry out the t-check analysis difference between the sample (p＜0.01) more in twos under oneway ANOVA.
Result and discussion
5.1 the influence that Chinese herbal medicine ultra micro powder feed additive increases child care pig body weight
Test is chosen 240 assorted pigs of (long * big) binary altogether as sample, adopts the mode of single-factor completely random to be divided into a test group and a control group, every group of each 120 piglet, and the test age in days is gone through 32 days phases from 24 ages in days-56 age in days.It is as shown in table 2 that body weight increases situation, test group initial weight 6.12 ± 0.03 kg/ heads, and the end weighs 18.17 ± 0.22 kg/ heads, and 12.05 kg increase weight; Control group initial weight 6.20 ± 0.03 kg/ heads, the end weighs 17.38 ± 0.20 kg/ heads, and 11.18 kg/ heads increase weight.Test group manys weightening finish 0.87 kg/ head than control group, has improved 7.78%.
The influence that table 2 Chinese herbal medicine ultra micro powder feed additive increases child care pig body weight
5.2 Chinese herbal medicine ultra micro powder feed additive is to the influence of child care pig survival rate
Child care pig survival rate situation is as shown in table 3, and test group is chosen 120 weanling pigs altogether, and livestock on hand is 115 during off-test, and survival rate is 95.83%; Control group is chosen 120 weanling pigs, and livestock on hand is 110 during off-test, and survival rate is 91.67%.Test group is formed motility rate than contrast and has been improved 4.54 percentage points.
Table 3 Chinese herbal medicine ultra micro powder is to the influence of child care pig survival rate
5.3 Chinese herbal medicine ultra micro powder feed additive is to the influence of child care stage feedstuff-meat ratio
The feed consumption situation in child care stage is as shown in table 4, and test group is 1387.20 kg at the total augment weight in child care stage, and total feed consumption is 2003.30 kg, and feedstuff-meat ratio is 1.44; Control group is 1229.35 kg at the total augment weight in child care stage, and total feed consumption is 1905.15 kg, and feedstuff-meat ratio is 1.55.The feedstuff-meat ratio of test group has descended 0.11 than control group.
Table 4 Chinese herbal medicine ultra micro powder feed additive is to the influence of child care stage feedstuff-meat ratio
Claims (10)
1. the preparation method of a Chinese herbal medicine ultra micro powder feed additive may further comprise the steps:
Said composition is formulated by a certain percentage by medicines such as the Radix Astragali, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peels, the steps include:
(1) with the Radix Astragali, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel difference segment 2-4cm;
(2) Radix Astragali after the segment, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel being done the 150-160 order respectively pulverizes;
(3) getting certain proportion of astragalus, Chinese yam rhizome, hawthorn, Radix Codonopsis, radix bupleuri, Radix Glycyrrhizae and dried orange peel pulvis fully mixes;
(4) further said mixture is made ultramicro grinding and handled, make average grain diameter be about 30 μ m, sealing is preserved after the packing.
2. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
3. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
。
4. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
5. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
6. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
7. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
8. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
9. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
10. a kind of Chinese herbal medicine ultra micro powder feed additive according to claim 1 is characterized in that it is to be made by the medicine material of following mass percent:
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Cited By (6)
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| CN103494996A (en) * | 2013-09-29 | 2014-01-08 | 青岛农业大学 | Pharmaceutical composition for improving immunity of livestock and poultry and preparation method of pharmaceutical composition |
| CN103734551A (en) * | 2014-01-29 | 2014-04-23 | 王勇强 | Fattening agent for meat goats |
| CN104489416A (en) * | 2015-01-14 | 2015-04-08 | 安徽科技学院 | Immunity-enhancing high-yield Chinese herb feed additive for broiler chicken |
| CN105124159A (en) * | 2015-09-28 | 2015-12-09 | 金陵科技学院 | Traditional Chinese medicine feed additive for improving immune function of pigs as well as preparation method and application of additive |
| CN106474460A (en) * | 2016-10-31 | 2017-03-08 | 郑州普罗动物药业有限公司 | A kind of for prevention and control porkling disease from Ru-an granules and preparation method thereof |
| CN108497181A (en) * | 2017-05-27 | 2018-09-07 | 苏州凯茂饲料添加剂有限公司 | A kind of sow in lactation mixed feed |
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| CN105124159B (en) * | 2015-09-28 | 2018-06-19 | 金陵科技学院 | A kind of Chinese herbal feed additive for improving pig immune function and its preparation method and application |
| CN106474460A (en) * | 2016-10-31 | 2017-03-08 | 郑州普罗动物药业有限公司 | A kind of for prevention and control porkling disease from Ru-an granules and preparation method thereof |
| CN108497181A (en) * | 2017-05-27 | 2018-09-07 | 苏州凯茂饲料添加剂有限公司 | A kind of sow in lactation mixed feed |
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Application publication date: 20130911 |