CN102805774A - Chinese medicinal superfine powder for improving organism immunity of livestock and poultry and preparation method thereof - Google Patents
Chinese medicinal superfine powder for improving organism immunity of livestock and poultry and preparation method thereof Download PDFInfo
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Abstract
The invention aims to provide Chinese medicinal superfine powder for improving the organism immunity of livestock and poultry. The Chinese medicinal superfine powder is prepared by performing superfine grinding on raw materials such as honeysuckle flower, wild chrysanthemum, Vietnamese sophora root, heartleaf houttuynia herb, acanthopanax root, umbellate pore fungus, dangshen, astragalus, puer tea, snakegourd fruit husk, storax, Chinese osbeckia herb, vitamin E, superfine silica powder and mannitol twice. The Chinese medicinal superfine powder has the advantages that 1, the fineness of the powder is uniform, and bioavailability is improved; 2, the medicinal effect of the powder is strengthened, the immunity of the livestock and the poultry can be effectively improved, the serious morbidity of the livestock and the poultry is prevented, and the survival rate and slaughtering rate of the livestock and the poultry are improved; 3, the superfine powder is environment-friendly and safe, and does not have any toxic or side effect or medicine residue; and 4) the superfine powder has a reasonable formula and is effectively oxidation-resistant and coagulation-resistant, and convenient to produce, transport and store.
Description
Technical field
The present invention relates to a kind of Chinese medicine for animals, be specifically related to a kind of superfine powder Chinese medicine that improves the poultry immunity of organisms.
Background technology
Along with Developing of Animal Industry, the reasonable prevention and control of livestock and poultry occupy more and more important position.Except the control of some extrinsic factor, the raising of poultry self body immunity also becomes the problem that relevant experts and scholars pay close attention to.Point out QI invigorating in the Chinese herbal medicine in the traditional Chinese medical science immunology, enrich blood, medical material such as nourishing YIN, YANG invigorating; Immunoreation to low has facilitation; The function of ability human body immunity improving system; The resistance against diseases of enhancing body promotes immunoreation to carry out towards the aspect that helps body, reaches the purpose of cure diseases.
Through scientific compatibility, under the synergism between Chinese medicine, drug effect often can increase considerably; But to extract degree not high because conventional Chinese medicinal preparation method all has effective substance; Even destroy defective such as Chinese traditional medicine biology activity in the course of processing, however adopt the superfine comminution at low temperature technology, not only can avoid above-mentioned defective; Keep the effective ingredient of medicine constant, and can improve the fineness and the flowability of material with composition.Also just because of outside ultra micro Chinese medicine powder active substance is exposed to entirely; Its very easily oxidation, conglomeration even go mouldy; This has also seriously restricted the application of superfine powder technology at the field of Chinese medicines, chooses rational formula combination, can be when guaranteeing ultra micro Chinese medicine powder drug effect; Stablize the character of Chinese medicine powder, guarantee the quality in its useful life.。
Summary of the invention
The purpose of this invention is to provide a kind of compatibility science, and can effectively improve superfine powder Chinese medicine of poultry immunity of organisms and preparation method thereof.
The objective of the invention is to realize through following technical scheme:
A kind of Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 43-47g, Flos Chrysanthemi Indici 30-34g, Radix Sophorae Tonkinensis 26-30g, Herba Houttuyniae 16-20g, Radix Et Caulis Acanthopanacis Senticosi 34-38g, Polyporus 32-36g, Radix Codonopsis 23-27g, Radix Astragali 16-20g.
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 43-47g, Flos Chrysanthemi Indici 30-34g, Radix Sophorae Tonkinensis 26-30g, Herba Houttuyniae 16-20g, Radix Et Caulis Acanthopanacis Senticosi 34-38g, Polyporus 32-36g, Radix Codonopsis 23-27g, Radix Astragali 16-20g.A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 30-70g, Flos Chrysanthemi Indici 20-60g, Radix Sophorae Tonkinensis 20-50g, Herba Houttuyniae 10-40g, Radix Et Caulis Acanthopanacis Senticosi 10-50g, Polyporus 20-50g, Radix Codonopsis 20-30g, Radix Astragali 15-20g, Folium camelliae assamicae 20-30g, Pericarpium Trichosanthis 5-8g, Styrax 12-20g, Radix Osbeckiae Crinitae 5-10g, vitamin E 10-20g, micropowder silica gel 10-25g, mannitol 15-30g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 20-30g coarse pulverization to 80 order; Place its quality 35-45 distilled water doubly again, in 70-85 ℃, the microwave of 200-300w, handle 15-30min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 1-3h gets powder M;
2, pulverize for the first time: Flos Lonicerae 30-70g, Flos Chrysanthemi Indici 20-60g, Radix Sophorae Tonkinensis 20-50g, Herba Houttuyniae 10-40g, Radix Et Caulis Acanthopanacis Senticosi 10-50g, Polyporus 20-50g, Radix Codonopsis 20-30g, Radix Astragali 15-20g, Pericarpium Trichosanthis 5-8g, Styrax 12-20g, Radix Osbeckiae Crinitae 5-10g, vitamin E 10-20g vacuum lyophilization 2-4h; Add feed bin; Chopping wheel through 3000-4000r/min is pulverized; Pulverizing time 20-60min; 6 blades evenly are installed on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder after will pulverizing for the first time and powder M, micropowder silica gel 10-25g, mannitol 15-30g mixing, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 15-40min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
In the present invention's prescription,
Flos Lonicerae: the flower that Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or band are just opened.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and like fever of the body, dermexanthesis, send out cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.
Flos Chrysanthemi Indici: be the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, contain and to be widely used in diseases such as treatment furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, headache be dizzy.Simultaneously good hypotensive effect is arranged again, can be used for the auxiliary treatment of hypertension.
Radix Sophorae Tonkinensis: be the dry root and rhizome of Dicotyledoneae leguminous plant Sophora tonkinensis Gagnep..Little have a bean stink smell, and flavor is extremely bitter.Function cures mainly: the detoxifcation of relieving inflammation or internal heat, reducing swelling and alleviating pain.Be used for throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention.
Herba Houttuyniae: cold nature, bitter in the mouth, major function is heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome; Cure mainly: the lung abscess vomiting pus; The expectorant dyspnea of heat type is coughed; Throat; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.
Radix Et Caulis Acanthopanacis Senticosi: cure mainly anemofrigid-damp arthralgia; Lumbocrural pain; The muscles and bones flaccidity is soft; Be slow in action; A little less than the body weakness with emaciation; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched.Its record in " practical Chinese medicine one book of taking a tonic or nourishing food to build up one's health " belongs to Qi-tonifying drug, has the effect that tonify deficiency is helped the weak, and can prevent or treat the disease that has a delicate constitution, strengthening by means of tonics, life lengthening.
Polyporus: be the dry sclerotia of Polyporaceae fungus Polyporus Polyporus umbellatus (Pers.) Fries.Sweet in the mouth, light, flat is returned kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen.Control dysuria, edema, have loose bowels stranguria with turbid discharge, leukorrhagia.
Radix Codonopsis: contain various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and micro-alkaloid, have effects such as enhancing immunity, blood vessel dilating, blood pressure lowering, microcirculation improvement, enhancing hemopoietic function.The leukopenia that in addition chemotherapy radiotherapy is caused has castering action.
The Radix Astragali: be leguminous herbaceous plant, contain various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.The enhancing human body immunity function arranged, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Folium camelliae assamicae: have blood fat reducing, fat-reducing, skin care, blood pressure lowering, arteriosclerosis, anti-cancer, anticancer, protect effects such as harmonization of the stomach nourishing the stomach.
Pericarpium Trichosanthis: be the peel of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms etc.Has moistening the lung and resolving phlegm, the promoting the circulation of QI the chest stuffiness relieving.Control phlegm-heat cough, pharyngalgia, chest pain is spitted blood, and epistaxis is quenched one's thirst, constipation, effects such as carbuncle pyogenic infections from tumour or sore.
Styrax: be the secreted resin of Hamamelidaceae plant Styrax tree LiquidambarorientalisMill., having has one's ideas straightened out ward off dirty, dissipating depression of QI eliminating phlegm, the effect of promoting the circulation of QI to relieve pain.
Radix Osbeckiae Crinitae: property is flat, and it is little sweet, puckery to distinguish the flavor of.Function cures mainly clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, relieving cough and resolving phlegm.Be used for acute bacillary dysentery, amebic dysentery, ameba liver abscess, enteritis, cold cough, laryngopharynx swelling and pain, bronchial asthma of child, hemoptysis of pulmonary tuberculosis, appendicitis, venom, furuncle furuncle and phyma.Water-soluble mono peace tannin two compounds of 6 kinds of complicacies such as benzoaric acid, gallic acid and gallic acid first be cruel are arranged in the Radix Osbeckiae Crinitae methanolic extract, and they all are better than tocopherol to oleic oxidation resistance except that gallic acid.From the acetic acid ethyl ester extract of Radix Osbeckiae Crinitae, separate obtaining matter quercetin, kaempferol and their three kinds of sugar two chemical compounds, also have than strong anti-oxidation property.
The present invention has following advantage:
1, powder fineness is even, good dispersion, and bioavailability improves;
2, drug effect strengthens, and can effectively improve immunity of livestock, prevents that serious incidence from appearring in poultry, improves the poultry survival rate and the rate of animals delivered to the slaughter-house simultaneously;
3, green safety has no side effect, and drug residue free;
4, prescription is reasonable, and effectively antioxidation, anti-agglomeration are convenient to production and transport and storage.
Specific embodiment
Below in conjunction with specific embodiment the present invention is done further explanation, to help understanding content of the present invention.
Embodiment 1:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g, Folium camelliae assamicae 26g, Pericarpium Trichosanthis 6g, Styrax 15g, Radix Osbeckiae Crinitae 7g, vitamin E 16g, micropowder silica gel 16g, mannitol 20g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 26g coarse pulverization to 80 order; Place the distilled water of 40 times of its quality again, in 80 ℃, the microwave of 300w, handle 25min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 1.5h gets powder M;
2, pulverize for the first time: Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g, Pericarpium Trichosanthis 6g, Styrax 15g, Radix Osbeckiae Crinitae 7g, vitamin E 16g vacuum lyophilization 2.5h; Add feed bin; Chopping wheel through 3600r/min is pulverized; Pulverizing time 30min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder after will pulverizing for the first time and powder M, micropowder silica gel 16g, mannitol 20g mixing, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 25min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
Embodiment 2:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 30g, Flos Chrysanthemi Indici 28g, Radix Sophorae Tonkinensis 22g, Herba Houttuyniae 10g, Radix Et Caulis Acanthopanacis Senticosi 40g, Polyporus 45g, Radix Codonopsis 20g, Radix Astragali 15g, Folium camelliae assamicae 30g, Pericarpium Trichosanthis 5g, Styrax 12g, Radix Osbeckiae Crinitae 5g, vitamin E 20g, micropowder silica gel 12g, mannitol 16g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 30g coarse pulverization to 80 order; Place the distilled water of 35 times of its quality again, in 70 ℃, the microwave of 200w, handle 30min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 2h gets powder M;
2, pulverize for the first time: Flos Lonicerae 30g, Flos Chrysanthemi Indici 28g, Radix Sophorae Tonkinensis 22g, Herba Houttuyniae 10g, Radix Et Caulis Acanthopanacis Senticosi 40g, Polyporus 45g, Radix Codonopsis 20g, Radix Astragali 15g, Pericarpium Trichosanthis 5g, Styrax 12g, Radix Osbeckiae Crinitae 5g, vitamin E 20g vacuum lyophilization 2h; Add feed bin; Chopping wheel through 3000r/min is pulverized; Pulverizing time 25min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder and powder M mixing after will pulverizing for the first time, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 35min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
Embodiment 3:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 65g, Flos Chrysanthemi Indici 55g, Radix Sophorae Tonkinensis 30g, Herba Houttuyniae 20g, Radix Et Caulis Acanthopanacis Senticosi 20g, Polyporus 22g, Radix Codonopsis 28g, Radix Astragali 18g, Folium camelliae assamicae 20g, Pericarpium Trichosanthis 8g, Styrax 18g, Radix Osbeckiae Crinitae 10g, vitamin E 10g, micropowder silica gel 15g, mannitol 22g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 20g coarse pulverization to 80 order; Place the distilled water of 45 times of its quality again, in 85 ℃, the microwave of 300w, handle 15min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 3h gets powder M;
2, pulverize for the first time: Flos Lonicerae 65g, Flos Chrysanthemi Indici 55g, Radix Sophorae Tonkinensis 30g, Herba Houttuyniae 20g, Radix Et Caulis Acanthopanacis Senticosi 20g, Polyporus 22g, Radix Codonopsis 28g, Radix Astragali 18g, Pericarpium Trichosanthis 8g, Styrax 18g, Radix Osbeckiae Crinitae 10g, vitamin E 10g vacuum lyophilization 2-4h; Add feed bin; Chopping wheel through 4000r/min is pulverized; Pulverizing time 60min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder after will pulverizing for the first time and powder M, micropowder silica gel 15g, mannitol 22g mixing, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 40min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
Embodiment 4:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 45g, Flos Chrysanthemi Indici 25g, Radix Sophorae Tonkinensis 60g, Herba Houttuyniae 55g, Radix Et Caulis Acanthopanacis Senticosi 40g, Polyporus 55g, Radix Codonopsis 32g, Radix Astragali 26g, Folium camelliae assamicae 50g, Pericarpium Trichosanthis 12g, Styrax 24g, Radix Osbeckiae Crinitae 12g, vitamin E 25g, micropowder silica gel 20g, mannitol 28g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 50g coarse pulverization to 80 order; Place the distilled water of 45 times of its quality again, in 85 ℃, the microwave of 300w, handle 30min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 3h gets powder M;
2, pulverize for the first time: Flos Lonicerae 45g, Flos Chrysanthemi Indici 25g, Radix Sophorae Tonkinensis 60g, Herba Houttuyniae 55g, Radix Et Caulis Acanthopanacis Senticosi 40g, Polyporus 55g, Radix Codonopsis 32g, Radix Astragali 26g, Pericarpium Trichosanthis 12g, Styrax 24g, Radix Osbeckiae Crinitae 12g, vitamin E 25g vacuum lyophilization 4h; Add feed bin; Chopping wheel through 4000r/min is pulverized; Pulverizing time 70min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder after will pulverizing for the first time and powder M, micropowder silica gel 20g, mannitol 28g mixing, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 50min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
Embodiment 5:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 20g, Flos Chrysanthemi Indici 16g, Radix Sophorae Tonkinensis 35g, Herba Houttuyniae 26g, Radix Et Caulis Acanthopanacis Senticosi 45g, Polyporus 15g, Radix Codonopsis 15g, Radix Astragali 12g, Folium camelliae assamicae 15g, Pericarpium Trichosanthis 3g, Styrax 10g, Radix Osbeckiae Crinitae 3g, vitamin E 8g, micropowder silica gel 12g, mannitol 15g;
Wherein, Radix Osbeckiae Crinitae and vitamin E are antioxidant; Micropowder silica gel and mannitol are anticaking agents;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
1, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 15g coarse pulverization to 80 order; Place the distilled water of 35 times of its quality again, in 70 ℃, the microwave of 200w, handle 15min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 4h gets powder M;
2, pulverize for the first time: Flos Lonicerae 20g, Flos Chrysanthemi Indici 16g, Radix Sophorae Tonkinensis 35g, Herba Houttuyniae 26g, Radix Et Caulis Acanthopanacis Senticosi 45g, Polyporus 15g, Radix Codonopsis 15g, Radix Astragali 12g, Pericarpium Trichosanthis 3g, Styrax 10g, Radix Osbeckiae Crinitae 3g, vitamin E 8g vacuum lyophilization 2h; Add feed bin; Chopping wheel through 3000r/min is pulverized; Pulverizing time 15min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
3, pulverize the second time: Chinese medicine powder after will pulverizing for the first time and powder M, micropowder silica gel 12g, mannitol 15g mixing, place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 12min;
4, the Chinese medicine powder packing after twice micronizing is put in storage.
Embodiment 6:
A kind of superfine powder Chinese medicine that improves the poultry immunity of organisms is processed by the supplementary material of following weight proportioning: Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g;
The superfine powder Chinese medicine of above-mentioned raising poultry immunity of organisms is made by following steps:
With Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g, vacuum lyophilization 2h; Add feed bin; Chopping wheel through 3600r/min is pulverized; 6 blades evenly are installed on its turntable, and each blade is inclined upwardly 30 °; Chinese medicine powder and powder M mixing that will be after chopping wheel is pulverized place the crushing chamber of jet mill to carry out the second time and pulverize.At last the Chinese medicine powder packing after twice micronizing is put in storage.
Test Example:
One, will raise to 140 of the chickling of 7 ages in days through preparation; Be divided into 7 groups at random, 20 every group, 1-6 group in feedstuff, add respectively feedstuff gross mass 1% by the prepared ultra micro Chinese medicine powder of embodiment 1-5, embodiment 6; Matched group does not add any medicine; 1-6 group successive administration 20 days, each group adopts identical conventional feeding and management condition, 9 weeks of experimental period.
Test Example 1:ND antibody horizontal is measured
Chickling in 7 days, 21 ages in days with LaSota vaccine routine immunization; And respectively at 10 blood samplings of each picked at random of 14,21,28,35 ages in days; Remaining 10 takes a blood sample respectively at 42,49,56,63 ages in days; Separation of serum carries out hemagglutination inhibition test (HI) by conventional method with 96 hole V-type blood-coagulation-boards, and the blood clotting of NDV serum antibody suppresses to tire to represent with log2.The result sees table 1:
The situation of change table of table 1 chicken blood HI antibody
| Group | Quantity | 14 days | 21 days | 28 days | 35 days | 42 days | 49 days | 56 days | 63 days |
| Embodiment 1 | 20 | 6.0±1.22 | 5.8±0.57 | 6.7±0.81 | 8.3±1.07 | 9.2±0.60 | 8.6±0.32 | 8.5±1.16 | 8.4±0.74 |
| Embodiment 2 | 20 | 5.9±1.86 | 6.0±0.99 | 6.3±0.51 | 7.9±0.17 | 8.8±0.74 | 8.5±1.46 | 8.2±1.11 | 8.1±0.62 |
| Embodiment 3 | 20 | 6.2±0.67 | 6.0±1.05 | 6.5±1.36 | 8.0±1.75 | 8.4±0.93 | 8.9±1.46 | 8.1±0.39 | 7.9±0.99 |
| Embodiment 4 | 20 | 6.3±1.13 | 5.6±0.61 | 6.0±1.05 | 7.5±0.62 | 8.0±1.24 | 7.6±0.39 | 7.8±0.57 | 7.4±1.53 |
| Embodiment 5 | 20 | 6.1±0.85 | 5.8±1.46 | 6.2±0.53 | 7.7±0.97 | 8.1±1.30 | 7.8±0.24 | 7.8±0.56 | 7.6±0.77 |
| Embodiment 6 | 20 | 5.8±1.16 | 5.9±0.70 | 6.2±1.35 | 7.4±0.65 | 7.7±0.41 | 7.5±0.87 | 7.3±0.58 | 7.3±1.03 |
| Matched group | 20 | 5.5±0.82 | 4.2±1.43 | 6.0±0.79 | 6.8±1.21 | 7.2±0.69 | 6.9±1.13 | 7.0±0.62 | 6.8±0.79 |
Can find out by table 1; The effect that all improves of embodiment 1-5,6 couples of chickling ND of embodiment antibody horizontal; Wherein with embodiment 1 best results, remarkable since 21 age in days antibody horizontals and embodiment 6, matched group comparing difference, and antibody horizontal reaches 9.2log2 when 42 ages in days.
Test Example 2: the exponential mensuration of immune organ:
Each group is respectively randomly drawed 10 at 21,28,35,63 ages in days respectively, cuts open and wins fabricius bursa, spleen extremely, inhale the moisture go to the surface with filter paper after, weigh with analytical balance, calculate fabricius bursa exponential sum index and spleen index according to ratio with body weight.Press following Gong Shijisuanfashi capsule exponential sum index and spleen index: fabricius bursa index=fabricius bursa weight in wet base (mg)/body weight (g); Index and spleen index=spleen weight in wet base (mg)/body weight (g).The result sees table 2, table 3:
The information slip of table 2 index and spleen index
| Age in days (my god) | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Matched group |
| 21 | 2.4±0.68 | 2.5±0.31 | 2.2±0.29 | 1.9±0.85 | 2.0±0.64 | 1.8±0.70 | 1.5±1.09 |
| 28 | 3.3±1.04 | 3.0±1.01 | 2.9±1.13 | 2.8±1.60 | 2.9±1.16 | 2.6±0.62 | 2.6±0.25 |
| 35 | 4.0±0.55 | 3.7±0.99 | 3.6±1.06 | 3.2±0.59 | 3.4±0.34 | 3.0±0.91 | 2.7±0.67 |
| 63 | 3.5±1.27 | 3.4±0.36 | 3.2±0.47 | 3.1±0.73 | 3.1±1.18 | 2.9±0.61 | 2.8±0.44 |
Table 3 fabricius bursa index information slip
| Age in days (my god) | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Matched group |
| 21 | 7.0±0.35 | 6.7±1.02 | 6.8±0.86 | 5.9±0.54 | 6.0±0.41 | 5.5±0.56 | 5.0±0.49 |
| 28 | 6.8±0.50 | 6.8±0.76 | 6.6±0.73 | 6.3±0.83 | 6.2±1.20 | 5.9±0.72 | 6.4±0.73 |
| 35 | 6.6±0.19 | 6.4±0.58 | 5.8±1.08 | 6.1±0.29 | 6.3±0.36 | 6.0±0.48 | 5.6±1.42 |
| 63 | 5.2±0.24 | 4.9±0.27 | 4.7±0.99 | 4.4±0.65 | 4.5±0.31 | 3.7±0.22 | 4.5±0.97 |
Table 3 result shows: the fabricius bursa index is when 21,35 ages in days, and embodiment 1-5,6 groups of embodiment and matched group more all have significance to improve.And embodiment 1 index is the highest, and is still high than other groups during to 63 ages in days.
Two, selecting age in days is 25 ± 3 days, and parity is approaching, piglet after good 140 wean of health level; Be divided into 7 groups at random; Every group 20,1-6 group in feedstuff, add respectively feedstuff gross mass 1% by the prepared ultra micro Chinese medicine powder of embodiment 1-5, embodiment 6, matched group does not add any medicine; Feeding one month raises by routine that other are constant with immunity.
Test Example 3:
Observe every day and write down and respectively organize piglet feed intake and health status.Weigh with finishing the same day pig only being carried out empty stomach in on-test.Observe piglet growth situation and morbidity and death condition every day after on-test.The result sees table 4, table 5:
Table 4 piglet body weight change situation
| Group | First gross weight | The end gross weight | First counterpoise | The end counterpoise | Total augment weight | Every weightening finish | Daily gain |
| Embodiment 1 | 160.4 | 333.6 | 8.02 | 16.68 | 173.2 | 8.66 | 0.289 |
| Embodiment 2 | 160.6 | 332.0 | 8.03 | 16.60 | 171.4 | 8.57 | 0.286 |
| Embodiment 3 | 161.2 | 333.8 | 8.06 | 16.69 | 172.6 | 8.63 | 0.288 |
| Embodiment 4 | 160.0 | 327.4 | 8.00 | 16.37 | 167.4 | 8.37 | 0.279 |
| Embodiment 5 | 160.2 | 328.2 | 8.01 | 16.41 | 168.0 | 8.40 | ?0.280 |
| Embodiment 6 | 160.8 | 326.0 | 8.04 | 16.30 | 165.2 | 8.26 | 0.275 |
| Matched group | 160.6 | 319.0 | 8.03 | 15.95 | 158.4 | 7.92 | 0.264? |
Table 5 piglet falls ill and becomes to live situation
| Group | A morbidity number | Isolate a number | A dead number | Survival rate (%) |
| Embodiment 1 | 1 | 0 | 0 | 100 |
| Embodiment 2 | 2 | 0 | 0 | 100 |
| Embodiment 3 | 2 | 1 | 0 | 100 |
| Embodiment 4 | 3 | 2 | 1 | 95 |
| Embodiment 5 | 4 | 2 | 1 | 95 |
| Embodiment 6 | 4 | 4 | 2 | 90 |
| Matched group | 6 | 5 | 3 | 85 |
Can find out that from table 4 add in the superfine powder experimental group of feed embodiment 1-3 preparation, the piglet daily gain significantly improves; This mainly is because superfine powder improves the immunity of organisms of piglet; Promote the utilization rate of nutrient substance in intestinal, the swinery uniformity is better, and the average weight gain ratio is higher.
Can find out that from table 5 a superfine powder morbidity number that adds feed embodiment 1-3 preparation has lacked 5 than matched group, see that from isolated instances a matched group isolation number is also many than other experimental grouies.Matched group is fallen ill dead 2, and this has also reacted the raising of superfine powder to whole swinery health level to a certain extent.With respect to matched group, the piglet mental status of embodiment 1-2 experimental group is good, and the red hair of skin is bright, fever and cough with breathe less.This explanation Chinese medicine ultra-fine powder can improve the resistance of piglet, prevents that effectively serious incidence from appearring in piglet, improves the piglet survival ratio and the rate of animals delivered to the slaughter-house simultaneously.Solve the stress of baby pigs caused ablaction syndrome preferably, make the ablactational baby pig smooth transition to the piglets stage.
Claims (6)
1. a superfine powder Chinese medicine that improves the poultry immunity of organisms is characterized in that: processed by supplementary material: Flos Lonicerae, Flos Chrysanthemi Indici, Radix Sophorae Tonkinensis, Herba Houttuyniae, Radix Et Caulis Acanthopanacis Senticosi, Polyporus, Radix Codonopsis, the Radix Astragali.
2. superfine powder Chinese medicine that improves the poultry immunity of organisms, it is characterized in that: the supplementary material by the following weight proportioning is processed: Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g.
3. superfine powder Chinese medicine that improves the poultry immunity of organisms, it is characterized in that: the supplementary material by the following weight proportioning is processed: Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g, Folium camelliae assamicae 26g, Pericarpium Trichosanthis 6g, Styrax 15g, antioxidant are 28g, anticaking agents 36g.
4. a kind of superfine powder Chinese medicine that improves the poultry immunity of organisms according to claim 3 is characterized in that: antioxidant is Radix Osbeckiae Crinitae 12g, vitamin E 16g.
5. a kind of superfine powder Chinese medicine that improves the poultry immunity of organisms according to claim 3 is characterized in that: anticaking agents is micropowder silica gel 16g, mannitol 20g.
6. a kind of preparation technology who improves the superfine powder Chinese medicine of poultry immunity of organisms according to claim 3 is characterized in that:
A, Folium camelliae assamicae pretreatment: with Folium camelliae assamicae 26g coarse pulverization to 80 order; Place its quality 35-45 distilled water doubly again, in 70-85 ℃, the microwave of 200-300w, handle 15-30min; Cross and filter filtrating, filtrate decompression is concentrated into extractum, and vacuum lyophilization 1-3h gets powder M;
B, pulverizing for the first time: with Flos Lonicerae 45g, Flos Chrysanthemi Indici 32g, Radix Sophorae Tonkinensis 28g, Herba Houttuyniae 18g, Radix Et Caulis Acanthopanacis Senticosi 36g, Polyporus 34g, Radix Codonopsis 25g, Radix Astragali 18g, Pericarpium Trichosanthis 6g, Styrax 15g, antioxidant is 28g vacuum lyophilization 2-4h; Add feed bin; Chopping wheel through 3000-4000r/min is pulverized; Pulverizing time 20-60min evenly is equipped with 6 blades on its turntable, and each blade is inclined upwardly 30 °;
C, the second time pulverize: Chinese medicine powder after will pulverizing for the first time and powder M, anticaking agents 36g mixing, and place the crushing chamber of jet mill to carry out the pulverizing second time, pulverize time 15-40min;
D, with Chinese medicine powder after twice micronizing packing warehouse-in.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103222558A (en) * | 2013-04-08 | 2013-07-31 | 安徽省临泉山羊有限公司 | Goat feed containing biscuit additive and preparation method thereof |
| CN103283959A (en) * | 2013-01-29 | 2013-09-11 | 广州格拉姆生物科技有限公司 | Chinese herbal ultra-fine powder feed additive and its application in culture |
| CN105394363A (en) * | 2015-11-30 | 2016-03-16 | 马志 | Cow feed additive |
| CN105394425A (en) * | 2015-11-30 | 2016-03-16 | 马志 | Egg-laying duck feed additive |
| CN105724769A (en) * | 2016-02-01 | 2016-07-06 | 云南双江三祥养殖有限责任公司 | Pu'er tea-containing concentrated feed |
| CN106039258A (en) * | 2016-06-29 | 2016-10-26 | 中国人民解放军第三军医大学第附属医院 | Composition used for enhancing immunity and application thereof |
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| CN1223882A (en) * | 1998-01-20 | 1999-07-28 | 曹丽文 | Immunization powder |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103283959A (en) * | 2013-01-29 | 2013-09-11 | 广州格拉姆生物科技有限公司 | Chinese herbal ultra-fine powder feed additive and its application in culture |
| CN103222558A (en) * | 2013-04-08 | 2013-07-31 | 安徽省临泉山羊有限公司 | Goat feed containing biscuit additive and preparation method thereof |
| CN105394363A (en) * | 2015-11-30 | 2016-03-16 | 马志 | Cow feed additive |
| CN105394425A (en) * | 2015-11-30 | 2016-03-16 | 马志 | Egg-laying duck feed additive |
| CN105724769A (en) * | 2016-02-01 | 2016-07-06 | 云南双江三祥养殖有限责任公司 | Pu'er tea-containing concentrated feed |
| CN106039258A (en) * | 2016-06-29 | 2016-10-26 | 中国人民解放军第三军医大学第附属医院 | Composition used for enhancing immunity and application thereof |
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