CN105124159A - Traditional Chinese medicine feed additive for improving immune function of pigs as well as preparation method and application of additive - Google Patents
Traditional Chinese medicine feed additive for improving immune function of pigs as well as preparation method and application of additive Download PDFInfo
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- CN105124159A CN105124159A CN201510628641.6A CN201510628641A CN105124159A CN 105124159 A CN105124159 A CN 105124159A CN 201510628641 A CN201510628641 A CN 201510628641A CN 105124159 A CN105124159 A CN 105124159A
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Abstract
The invention discloses a traditional Chinese medicine feed additive for improving immune function of pigs as well as a preparation method and application of the additive. The additive is prepared from the following components in parts by weight: astragalus membranaceus, fructus alpiniae oxyphyllae, Chinese yam, endothelium corneum gigeriae galli, poria cocos, hawthorn, pinellia ternate, rhizoma atractylodis, ginger, fructus amomi and liquorice. The preparation method comprises the steps of drying, smashing, screening and uniformly mixing the raw materials by adopting a traditional Chinese medicine production device to prepare, adding a prepared traditional Chinese medicine preparation into basic ration of a small healthy Meishan pig of 60 days, uniformly blending to feed, and carrying out free choice feeding and free water drinking. Upon verification of tests, the method can obviously improve the concentration of total protein and albumin in porcine serum; can significantly improve the content of immune globulin IgG and the content of a complement C3 in the porcine serum; obviously improves the antibody level of post-inoculation swine fever; increases the pig spleen indexes. Moreover, the defects of various chemicals and antibiotics feed additives are overcome, toxic and side effects and drug residues do not exist, and the body immune function is improved while the production of green and high-quality animal products is guaranteed.
Description
Technical field
The present invention relates to and a kind ofly improve Chinese herbal feed additive of pig immunologic function and its preparation method and application, belong to field of feed additive technology.
Background technology
China is big country of raising pigs, along with the development gradually of intensive industrialized piggery, cultivation scale expands gradually, cultivation density is caused to increase, there is downward trend in the resistance of pig body, cause the incidence of disease of swine disease to raise gradually, this not only drastically influence the income of aquaculture, and more the rapid and healthy of aquaculture in serious threat.Therefore, improve the immunity of pig body, the incidence of disease reducing swine disease has more and more become the focal issue of aquaculture.But in recent years, in modern feed industry, widely using of antibiotic, hormone and other chemical synthetic drug feed addictive, causes food safety affair and frequently occurs, cause the fear that consumer is huge.Therefore, in order to not threaten the health of consumer, ensure the health of animal, animal product safe and reliable, the desirable immunomodulator of the feature such as find efficient, nontoxic, noresidue, have no drug resistance has become the striving direction of Chinese scholars.Chinese herbal medicine is the traditional medicine of China, has the multiple advantages such as aboundresources, cost are low, non-toxic, noresidue, natural sex.It is a kind of trustworthy green food additive.Therefore, the development and application of novel Chinese herbal feed additive more and more comes into one's own.Traditional Chinese medicine has the advantage place of preventing diseases instead for the treatment of diseases, and therefore, the present invention is under the guidance of traditional Chinese medical theory knowledge, and in conjunction with clinical practice, the Chinese herbal feed additive improving pig immunity has been invented in research.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese herbal feed additive improving pig immunologic function.
The technical problem that the present invention also will solve is to provide the preparation method of above-mentioned feed addictive.
The present invention also needs the technical problem solved to be to provide the application of above-mentioned feed addictive.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
Improve a Chinese herbal feed additive for pig immunologic function, it is made up of the component of following parts by weight: the Radix Astragali 15 ~ 20 parts, fructus alpiniae oxyphyllae 10 ~ 15 parts, Chinese yam 10 ~ 15 parts, the membrane of a chicken's gizzard 15 ~ 20 parts, 15 ~ 20 parts, Poria cocos, hawthorn 10 ~ 15 parts, the tuber of pinellia 10 ~ 15 parts, rhizoma atractylodis 5 ~ 10 parts, 5 ~ 10 parts, ginger, fructus amomi 10 ~ 15 parts and 1 ~ 5 part, Radix Glycyrrhizae.
The above-mentioned preparation method improving the Chinese herbal feed additive of pig immunologic function, by drying, the pulverizing respectively of the Radix Astragali of formula ratio, fructus alpiniae oxyphyllae, Chinese yam, the membrane of a chicken's gizzard, Poria cocos, hawthorn, the tuber of pinellia, rhizoma atractylodis, ginger, fructus amomi, Radix Glycyrrhizae, cross 100 mesh sieves, mix and get final product.
The above-mentioned Chinese herbal feed additive improving pig immunologic function improves the application in the medicine of pig immunologic function in preparation.Prove through test, originally can significantly improve total protein and albumin concentration in Swine serum; The content of content of immunoglobulin IgG and Complement C_3 in Swine serum can be significantly improved; Significantly improve the antibody horizontal of the rear swine fever of immunity; Increase pig spleen index.And overcome many drawbacks of various chemicals and antibiotics additive agent for feeding, there is no toxic and side effect and medicament residue, while raising body's immunity, ensure that the production of green, high-quality animal product.
Wherein, the described addition of Chinese herbal feed additive in feed improving pig immunologic function is 0.5 ~ 1.5wt%.
Beneficial effect: pig Chinese herbal feed additive of the present invention, its formula is theoretical according to traditional Chinese veterinary medicine, and make with the Chinese medicine of tonifying middle-Jiao and Qi, drying damp and strengthening spleen, regulating spleen and stomach and qi and blood, its preparation method is simple, and composition is not destroyed, and conveniently produces.60 ages in days feed can improve pig serum in level of complement and immunoglobulin content, enhanced machine body immunity function.Chinese herbal feed additive of the present invention has that service time is short, effect is high, the feature of safety non-toxic, obviously can promote humoral immune function and the resistance against diseases of pig.
Accompanying drawing explanation
Fig. 1 Chinese herbal feed additive is on the impact of total protein concentration in Swine serum, and * p<0.05 represents that the different group difference of same age in days point is remarkable.
Fig. 2 Chinese herbal feed additive is on the impact of albumin concentration in Swine serum, and * p<0.05 represents that the different group difference of same age in days point is remarkable.
Fig. 3 Chinese herbal feed additive is on the impact of IgG content in Swine serum, and * p<0.05 represents that the different group difference of same age in days point is remarkable.
Fig. 4 Chinese herbal feed additive is on the impact of IgM content in Swine serum, and * p<0.05 represents that the different group difference of same age in days point is remarkable.
Fig. 5 feed addictive is on the impact of Complement C_3 concentration in Swine serum, and * p<0.05 represents that the different group difference of same age in days point is remarkable.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1:
Pig Chinese herbal feed additive is made up of the component of following parts by weight:
The Radix Astragali 15 parts, fructus alpiniae oxyphyllae 10 parts, Chinese yam 10 parts, the membrane of a chicken's gizzard 15 parts, 15 parts, Poria cocos, hawthorn 10 parts, the tuber of pinellia 10 parts, rhizoma atractylodis 5 parts, 5 parts, ginger, fructus amomi 10 parts and 1 part, Radix Glycyrrhizae.
Production method is as follows:
(1) by above-mentioned raw materials, dry, pulverizing, excessively 100 objects are sieved for subsequent use according to a conventional method;
(2) by the raw material that sieves by above-mentioned part by weight, physics is mixed into solid powder, adopts vacuum packaging bag carry out packing and get final product.
Embodiment 2:
Pig Chinese herbal feed additive is made up of the component of following parts by weight:
The Radix Astragali 20 parts, fructus alpiniae oxyphyllae 15 parts, Chinese yam 15 parts, the membrane of a chicken's gizzard 20 parts, 20 parts, Poria cocos, hawthorn 15 parts, the tuber of pinellia 15 parts, rhizoma atractylodis 10 parts, 10 parts, ginger, fructus amomi 15 parts and 5 parts, Radix Glycyrrhizae.
Production method is with embodiment 1.
Embodiment 3:
Pig Chinese herbal feed additive is made up of the component of following parts by weight:
The Radix Astragali 18 parts, intelligence benevolence 13 parts, Chinese yam 13 parts, the membrane of a chicken's gizzard 18 parts, 18 parts, Poria cocos, hawthorn 12 parts, the tuber of pinellia 13 parts, rhizoma atractylodis 8 parts, 8 parts, ginger, fructus amomi 13 parts and 3 parts, Radix Glycyrrhizae.
Production method is with embodiment 1.
Embodiment 4:
The healthy little MeiShan pig of 16 60 ages in days is divided into control group and test group at random, often organizes 8, male and female half and half.Raising 1 week is adapted to, each group pig free choice feeding and drinking-water, Routine Management before test.Hog cholera vaccine carries out secondary immunity at 21 and 60 age in days by specifications, experiment pig ear tag.The normal basal diet of control group fed, test group adds 1wt% Chinese herbal feed additive (embodiment 2 prepares) in basal diet.Experimental period is 90d.Each group respectively after on-test when 14d, 35d, 56d and 78d, fasting 12h, in the blood sampling of vena cava anterior place, the centrifugal 15min of 3000r/min, separation of serum ,-20 DEG C of preservations are to be measured.By kit description measure albumin, total protein, Immunoglobulin IgM,
Immunoglobulin IgG, Complement C_3 and hog cholera antibody.
1 Chinese herbal feed additive is on the impact of albumin in Swine serum and total protein concentration
Fig. 1 is visible, compared with control group, adds Chinese herbal feed additive and can improve total protein concentration of serum in feed, and significantly raise when 35d (P < 0.05) (Fig. 1), puts difference At All Other Times not remarkable.Seralbumin concentration is remarkable rising (Fig. 2) compared with control group when 78d.
2 Chinese herbal feed additives are on the impact of Immunoglobulin IgG in Swine serum and IgM content
Fig. 3 is visible, compared with control group, add Chinese herbal feed additive in feed and can improve content of immunoglobulin IgG in Swine serum, and when 35d and 56d significant difference (P < 0.05), put indifference conspicuousness (Fig. 3) At All Other Times, but (Fig. 4) is not all made significant difference to each time point of IgM content in serum.
3 Chinese herbal feed additives are on the impact of Complement C_3 concentration in Swine serum
Compared with control group, in feed, add Chinese herbal feed additive, the content (P < 0.05) of Complement C_3 in serum can be significantly improved when 35d, put difference At All Other Times not significantly (Fig. 5).
4 Chinese herbal feed additives are on the impact of hog cholera antibody level
As shown in Table 1, Chinese herbal feed additive group after experiment 14,35 and 56d hog cholera antibody level be significantly higher than control group (P < 0.05), and difference is not remarkable when 78d.
Table 1 Chinese herbal feed additive is on the impact (blocking-up rate %) of hog cholera antibody level
Claims (4)
1. one kind is improved the Chinese herbal feed additive of pig immunologic function, it is characterized in that, it is made up of the component of following parts by weight: the Radix Astragali 15 ~ 20 parts, fructus alpiniae oxyphyllae 10 ~ 15 parts, Chinese yam 10 ~ 15 parts, the membrane of a chicken's gizzard 15 ~ 20 parts, 15 ~ 20 parts, Poria cocos, hawthorn 10 ~ 15 parts, the tuber of pinellia 10 ~ 15 parts, rhizoma atractylodis 5 ~ 10 parts, 5 ~ 10 parts, ginger, fructus amomi 10 ~ 15 parts and 1 ~ 5 part, Radix Glycyrrhizae.
2. the preparation method improving the Chinese herbal feed additive of pig immunologic function according to claim 1, it is characterized in that, by drying, the pulverizing respectively of the Radix Astragali of formula ratio, fructus alpiniae oxyphyllae, Chinese yam, the membrane of a chicken's gizzard, Poria cocos, hawthorn, the tuber of pinellia, rhizoma atractylodis, ginger, fructus amomi, Radix Glycyrrhizae, cross 100 mesh sieves, mix and get final product.
3. the Chinese herbal feed additive improving pig immunologic function according to claim 1 improves the application in the medicine of pig immunologic function in preparation.
4. application according to claim 3, is characterized in that, the described addition of Chinese herbal feed additive in feed improving pig immunologic function is 0.5 ~ 1.5wt%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106578388A (en) * | 2016-12-23 | 2017-04-26 | 阳江双胞胎饲料有限公司 | Feed additive capable of enhancing piglet immunity |
| CN110692820A (en) * | 2019-11-26 | 2020-01-17 | 陈春 | Traditional Chinese medicine feed additive for improving autoimmune function of pigs and preparation method thereof |
| CN112715765A (en) * | 2020-12-24 | 2021-04-30 | 贵州大学 | Chinese herbal medicine immunoregulation feed additive for enhancing immune system of fattening pigs and application |
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| CN102258149A (en) * | 2011-08-25 | 2011-11-30 | 福建养宝生物股份有限公司 | Chinese herbal medicine formulation for pig starter feed |
| CN103283959A (en) * | 2013-01-29 | 2013-09-11 | 广州格拉姆生物科技有限公司 | Chinese herbal ultra-fine powder feed additive and its application in culture |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102258149A (en) * | 2011-08-25 | 2011-11-30 | 福建养宝生物股份有限公司 | Chinese herbal medicine formulation for pig starter feed |
| CN103283959A (en) * | 2013-01-29 | 2013-09-11 | 广州格拉姆生物科技有限公司 | Chinese herbal ultra-fine powder feed additive and its application in culture |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578388A (en) * | 2016-12-23 | 2017-04-26 | 阳江双胞胎饲料有限公司 | Feed additive capable of enhancing piglet immunity |
| CN110692820A (en) * | 2019-11-26 | 2020-01-17 | 陈春 | Traditional Chinese medicine feed additive for improving autoimmune function of pigs and preparation method thereof |
| CN112715765A (en) * | 2020-12-24 | 2021-04-30 | 贵州大学 | Chinese herbal medicine immunoregulation feed additive for enhancing immune system of fattening pigs and application |
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Effective date of registration: 20200629 Address after: No.374 Kangning Road, Liuyang economic and Technological Development Zone, Changsha City, Hunan Province Patentee after: HUNAN TAIFENG ANIMAL PHARMACEUTICAL Co.,Ltd. Address before: Qixia Xiaozhuang Village Center District of Nanjing City, Jiangsu province 210000 No. 130 Patentee before: JINLING INSTITUTE OF TECHNOLOGY |
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