CN109481591A - The Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis - Google Patents

The Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis Download PDF

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Publication number
CN109481591A
CN109481591A CN201811611171.2A CN201811611171A CN109481591A CN 109481591 A CN109481591 A CN 109481591A CN 201811611171 A CN201811611171 A CN 201811611171A CN 109481591 A CN109481591 A CN 109481591A
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medicine composition
chinese medicine
chinese
preparation
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刘鼎阔
董惠峰
刘芳
李源
胡鹏程
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
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Abstract

The present invention relates to a kind of Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis, the component and its weight fraction ratio of the Chinese medicine composition are respectively as follows: 10-20 parts of kuh-seng;10-20 parts of Changshan;15-25 parts of the leaf of bamboo;10-15 parts of the coptis;10-15 parts of the Chinese bulbul;10-15 parts of cape jasmine;10-15 parts of Radix Glycyrrhizae;5-20 parts of Verbena officinalis;15-25 parts of cimicifugae foetidae;10-20 parts of azedarach;10-15 parts of radix aucklandiae;10-15 parts of stone-like omphalia;10-20 parts of rhizome of cyrtomium.The present invention uses rear drug residue free, has no toxic side effect, and easily absorbs, easy to use, the requirement for meeting safe veterinary drug, ensureing animal-derived food safety, is a kind of Chinese medicine composition of ideal treatment curing gallinaceous leucocyto zoonosis.

Description

The Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis.
Background technique
Curing gallinaceous leucocyto zoonosis is that chicken leucocyte protozoon parasitizes caused a kind of hemosporidia in the leucocyte and red blood cell of chicken Disease;There are many chicken leucocyte protozoons, wherein it is most common with Leucocytozoon caulleryi, and endanger most serious.Generally with summer and autumn Season mostly occurs, and for infected chicken characterized by musculature and the extensive bleeding of internal organs, cockscomb blood loss is pale and gains the name.
This disease has generation, especially southern area of China more universal in many places of China, is often in endemic conditions, right Chick harm is serious, often causes large quantities of death, causes great economic loss to poultry husbandry.
Summary of the invention
The present invention uses rear drug residue free, has no toxic side effect, and easily absorbs, easy to use, meets safe veterinary drug, ensures and move The requirement of material resource food safety is a kind of Chinese medicine composition of ideal treatment curing gallinaceous leucocyto zoonosis.
It is another object of the present invention to provide a kind of preparation methods of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis, the component and its weight fraction ratio of Chinese medicine composition are respectively as follows:
10-20 parts of kuh-seng;
10-20 parts of Changshan;
15-25 parts of the leaf of bamboo;
10-15 parts of the coptis;
10-15 parts of the Chinese bulbul;
10-15 parts of cape jasmine;
10-15 parts of Radix Glycyrrhizae;
5-20 parts of Verbena officinalis;
15-25 parts of cimicifugae foetidae;
10-20 parts of azedarach;
10-15 parts of radix aucklandiae;
10-15 parts of stone-like omphalia;
10-20 parts of rhizome of cyrtomium.
A kind of the step of preparation method of Chinese medicine composition that treating curing gallinaceous leucocyto zoonosis, preparation method, is as follows:
(1) kuh-seng, Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, liter are weighed respectively according to the weight ratio Fiber crops, azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are ground into powder, and all pass through 80 meshes respectively;
(2) by the kuh-seng after sieving in step (1), Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, liter Fiber crops, azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are put into blending tank, are sufficiently mixed uniformly to get into finished product treatment curing gallinaceous leucocyto zoonosis Drug composition.
The invention has the advantages and beneficial effects that:
1, the kuh-seng that contains in the Chinese medicine composition of this treatment curing gallinaceous leucocyto zoonosis, Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, The Chinese medicinal ingredients such as Radix Glycyrrhizae, Verbena officinalis, cimicifugae foetidae, azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium have curing gallinaceous leucocyto zoonosis caused by protozoon fine Preventive and therapeutic effect.
2, the Chinese traditional medicine composition amount of substance of this treatment curing gallinaceous leucocyto zoonosis is stablized, and is not influenced by temperature and pH value, easily absorbs, and uses It is convenient, it works well.
3, the present invention uses rear drug residue free, has no toxic side effect, and easily absorbs, easy to use, meets safe veterinary drug, guarantee The requirement of animal-derived food safety is a kind of Chinese medicine composition of ideal treatment curing gallinaceous leucocyto zoonosis.
Specific embodiment
The present invention is described in further detail by following embodiment.It should be understood that following embodiments be it is illustrative, be not It is limited, it cannot be limited the scope of protection of the present invention with following embodiments.
Kuh-seng according to the present invention, Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, cimicifugae foetidae, China tree Skin, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium can be commercially available on the market.
Embodiment 1
A kind of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis, the component and its weight of Chinese medicine composition are respectively as follows: kuh-seng 20g, Changshan 20g, leaf of bamboo 25g, coptis 15g, Chinese bulbul 15g, cape jasmine 15g, Radix Glycyrrhizae 15g, Verbena officinalis 20g, cimicifugae foetidae 25g, China tree Skin 20g, radix aucklandiae 15g, stone-like omphalia 15g, rhizome of cyrtomium 20g.
A kind of the step of preparation method of Chinese medicine composition that treating curing gallinaceous leucocyto zoonosis, preparation method, is as follows:
(1) kuh-seng, Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, liter are weighed respectively according to the weight ratio Fiber crops, azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are ground into powder, and all pass through 80 meshes respectively;
(2) by the kuh-seng after sieving in step (1), Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, liter Fiber crops, azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are put into blending tank, are sufficiently mixed uniformly to get into finished product treatment curing gallinaceous leucocyto zoonosis Drug composition.
Embodiment 2
A kind of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis, the component and its weight of Chinese medicine composition are respectively as follows: kuh-seng 15g, Changshan 15g, leaf of bamboo 20g, coptis 10g, Chinese bulbul 10g, cape jasmine 10g, Radix Glycyrrhizae 10g, Verbena officinalis 15g, cimicifugae foetidae 20g, China tree Skin 15g, radix aucklandiae 10g, stone-like omphalia 10g, rhizome of cyrtomium 15g.
The step of preparation method, is the same as embodiment 1.
Embodiment 3
A kind of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis, the component and its weight of Chinese medicine composition are respectively as follows: kuh-seng 10g, Changshan 15g, leaf of bamboo 20g, coptis 15g Chinese bulbul 15g, cape jasmine 10g, Radix Glycyrrhizae 15g, Verbena officinalis 10g, cimicifugae foetidae 15g, azedarach 15g, radix aucklandiae 15g, stone-like omphalia 10g, rhizome of cyrtomium 15g.
The step of preparation method, is the same as embodiment 1.
Clinical application
In order to verify the present invention to the clinical therapeutic efficacy of curing gallinaceous leucocyto zoonosis, we are in certain chicken farm of Weifang City, Shandong Province The present invention has been carried out to the clinical trial of curing gallinaceous leucocyto zoonosis.The present invention is divided into basic, normal, high three dosage and divided animal by test Group administration, evaluates therapeutic effect and optimum amount of the invention.
Material and method
1.1 experimental animal
Weifang City, Shandong Province chicken house.
1.2 trial drug
The present invention is prepared by our company.
1.3 test method
The case of curing gallinaceous leucocyto zoonosis is mainly made a definite diagnosis by clinical symptoms, then diseased chicken is grouped to progress at random by experimenter Treatment.
The grouping of 1.4 experimental animals and processing
The diseased chicken with curing gallinaceous leucocyto zoonosis clinical symptoms is chosen in chicken farm, and is randomly divided into 4 groups, every group 100.
1 group is tested as control group, is not processed;
2 groups are tested as low dose group of the present invention, 1/2 times of amount of clinical recommended dose (1 dose/every thousand plumages) administration, spice, company Continuous administration 5 days.
3 groups are tested as middle dose group of the present invention, clinical recommended dose (1 dose/every thousand plumages) is administered, spice, successive administration 5 It.
4 groups are tested as high dose group of the present invention, 2 times of amounts of clinical recommended dose (1 dose/every thousand plumages) are administered, spice, continuously Administration 5 days.
1.6 therapeutic effect determination methods
Observation diseased chicken cockscomb color, breathing, spirit, appetite behavior daily records diseased chicken number;The 3rd day after observation to drug withdrawal, By following standard determination total effects:
Cure: diseased chicken cockscomb color, breathing, spirit, appetite restore normal, without recurrence in drug withdrawal 7d.
Effective: diseased chicken cockscomb color, breathing, spirit, appetite make moderate progress, but do not restore completely.
Invalid: diseased chicken cockscomb color, breathing, spirit, appetite are not improved.
Total effective rate=cure rate+effective percentage.
1.7 statistical analysis
The percentages such as therapeutic effect cure rate, effective percentage and total effective rate indicate.Comparison in difference between group uses card side Inspection is analyzed.P < 0.05 and P < 0.01 respectively indicate significant difference and extremely significant.
2 test results
To the diseased chicken of natural infection curing gallinaceous leucocyto zoonosis, give the traditional chinese medicine composition of the invention of various dose respectively, by with it is right It is compared according to group, the clinical symptoms of diseased chicken are substantially reduced.The therapeutic effect higher dosage group of middle dose group is more preferable.It the results are shown in Table 1。
1 clinical observation on the therapeutic effect of table
3 interpretations of result
It is analyzed in terms of clinical symptoms, cure rate, effective percentage, total effective rate four, the therapeutic effect of middle dose group Higher than other treatment group.
4 conclusions
The present invention presses every 1 dose of thousand plumages chicken, treats to the diseased chicken with curing gallinaceous leucocyto zoonosis within continuous 5 days, imitates to curing gallinaceous leucocyto zoonosis Fruit is significant.

Claims (2)

1. a kind of Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis, it is characterised in that: the component and its parts by weight of the Chinese medicine composition Than are as follows:
10-20 parts of kuh-seng;
10-20 parts of Changshan;
15-25 parts of the leaf of bamboo;
10-15 parts of the coptis;
10-15 parts of the Chinese bulbul;
10-15 parts of cape jasmine;
10-15 parts of Radix Glycyrrhizae;
5-20 parts of Verbena officinalis;
15-25 parts of cimicifugae foetidae;
10-20 parts of azedarach;
10-15 parts of radix aucklandiae;
10-15 parts of stone-like omphalia;
10-20 parts of rhizome of cyrtomium.
2. a kind of preparation method for the Chinese medicine composition for treating curing gallinaceous leucocyto zoonosis as described in claim 1, it is characterised in that: the system The step of Preparation Method, is as follows:
(1) weigh respectively according to the weight ratio kuh-seng, Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, cimicifugae foetidae, Azedarach, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are ground into powder, and all pass through 80 meshes respectively;
(2) by the kuh-seng after sieving in step (1), Changshan, the leaf of bamboo, the coptis, the Chinese bulbul, cape jasmine, Radix Glycyrrhizae, Verbena officinalis, cimicifugae foetidae, hardship Chinaberry skin, radix aucklandiae, stone-like omphalia, rhizome of cyrtomium are put into blending tank, are sufficiently mixed uniformly to get the Chinese traditional medicine composition for treating curing gallinaceous leucocyto zoonosis to finished product Object.
CN201811611171.2A 2018-12-27 2018-12-27 The Chinese medicine composition and preparation method thereof for treating curing gallinaceous leucocyto zoonosis Withdrawn CN109481591A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110522890A (en) * 2019-08-15 2019-12-03 广东高山动物药业有限公司 Prevent and treat chicken rhinitis and the Chinese herbal feed additive of protozoosis and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110522890A (en) * 2019-08-15 2019-12-03 广东高山动物药业有限公司 Prevent and treat chicken rhinitis and the Chinese herbal feed additive of protozoosis and preparation method thereof

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Application publication date: 20190319