CN102688321B - Traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy - Google Patents
Traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy. The preparation is characterized by comprising the following components in parts by weight: 12-28 parts of raw Astragalus mongholicus, 3.75-8.75 parts of Angelica sinensis, 7.5-17.5 parts of motherwort herb, 6-14 parts of poria cocos, 6-14 parts of rhizome of swordlike atractylodes, 3.75-8.75 parts of dried orange peel, 6-14 parts of hawthorn, 6-14 parts of dandelion, 6-14 parts of purslane and 3-7 parts of liquorice. Compared with the prior art, the preparation has the advantages of adjusting and improving immunologic function of nursing sows, being beneficial for improving the heath of the sow group and the piglet group and being helpful for increasing the economic benefit of raising pigs.
Description
Technical field
The present invention relates to a kind of veterinary drug.
Background technology
China's pig industry is in fast-developing period at present, and the impact of swine diseases and threat are also on the rise.On the pig farm of scale, swine diseases presents mixed infection mostly, the features such as diagnosis control are distinguished, are difficult for to difficulty.Meanwhile, because restriction, the pig farm of feeding and management level are used for a long time in a large number and abuse various medicines, formulate unreasonable vaccination plan, the multiple stressors in pig farm etc., all can cause the decline of Swinery immunity function.Meanwhile, the phenomenon that the immunosuppressive disease occurring in recent years and some pathogen start to morph, virulence strengthens also makes Swinery immunity power and health level constantly decline, and swinery is also more and more higher to the susceptibility of disease.
Swinery immunity function reduction or immunosuppressant, directly affect swinery fertility performance, can bring huge economic loss to pig industry.Therefore the immunologic function that, how to improve swinery is the important topic of pendulum in face of veterinary research worker.When immunity of organism is disorderly, not what single immunopotentiating agent or immunostimulant just can onsets, usually need immunologic function to nurse one's health comprehensively, transfer all favorable factors of body and carry out balance immunoreation.Except strengthening feeding and management, reducing various stressors; also to actively take multiple effective measures to start body immune system, improve immunologic function, just can make to obtain better immunoprotection after swinery acquisition stronger premunition, immunne response ability and vaccination.
Sow group's health status, not only affects the reproductive performance of himself, and is related to piglet group's health.The improvement of sow production performance and immunologic function, can control the vertical transmission of disease and improve sow breeding achievement from source.After piglet birth, in the quite a while, its immunologic function is imperfection all, and all seldom, its immunoprotection is mainly the passive immunity obtaining from breast milk to the active immunity antibody that before weaned piglet, body produces.Research is found, also exists other to have anti-infection and strengthen immune material, and can directly by suckling process, enter in fetus body in milk except maternal antibody, newborn piglet is accepted to passive immunity, enhancing development, raising premunition and play an important role.In sum, the Disease in Infants factors such as quality height of the health status of trimester of pregnancy and sow in lactation, immunologic function height, breast milk will directly affect fertility performance and the resistance against diseases of piglet.Therefore, regulate nursing sow immunologic function to contribute to improve sow group and piglet group's health status, can help to improve the economic benefit of raising pigs.
Summary of the invention
The source of parents therapy that goal of the invention of the present invention is to provide a kind of adjusting, improve nursing sow health status immunologic function, that contribute to improve sow group and piglet group, help to improve the economic benefit of raising pigs is improved the Chinese medicine preparation of nursing sow and piglet health status thereof.
The present invention is achieved in that and comprises that weight content is the Radix Astragali of 12-28 part, the Radix Angelicae Sinensis that weight content is 3.75-8.75 part, the Herba Leonuri that weight content is 7.5-17.5 part, the Poria that weight content is 6-14 part, the Rhizoma Atractylodis that weight content is 6-14 part, the Pericarpium Citri Reticulatae that weight content is 3.75-8.75, the Fructus Crataegi that weight content is 6-14 part, the Herba Taraxaci that weight content is 6-14 part, the Herba Portulacae that weight content is 6-14 part, the Radix Glycyrrhizae that weight content is 3-7 part etc.
During use, in whole age of sucking (totally 21 days) of sow toward adding Chinese medicine compound 0.75%-1.5% sow of then feeding in feedstuff.
Here, for easy to use, Chinese medicine preparation is made mixture, granule, powder, superfine powder etc.
Prescription foundation
This is tested Chinese medicine compound used and comprises the 10 taste Chinese medicines such as Radix Astragali, Radix Angelicae Sinensis, Herba Leonuri, Poria, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Fructus Crataegi, Herba Taraxaci, Herba Portulacae, Radix Glycyrrhizae.
Selecting above-mentioned flavour of a drug, is in Chinese veterinarian's theoretical basis, sums up forefathers' clinical application experience, and strictly fastidious to each taste herbal nature, in conjunction with the achievement in research of modern Chinese medicine pharmacology, and finally determine by front clinical trial phase proved recipe.During compatibility, take and consider to regulate sow in lactation immunologic function as main, take into account simultaneously and considered by improving the source of parents factors such as breast milk quality to reach the effect that strengthens suckling pig immunologic function.At present, each taste Chinese medicine in prescription is a large amount of research report all, and this provides reference for we determine medicine plus-minus and consumption to a certain extent.From modern pharmacological research analysis, the selected Chinese medicine of we mostly has the effect of certain adjusting body's immunity.
Radix Astragali sweet in the mouth, slightly warm in nature, return lung, spleen, liver, kidney channel.Main effect is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration etc., and clinical practice is extremely extensive.Modern pharmacological research discovery, the Radix Astragali has immunity, antitumor, antiviral, antioxidation, the anti-ageing effect of waiting for a long time of enhancing body.The Radix Astragali can affect the growth of the immune organs such as animal thymus, spleen and fabricius bursa, promotes the phagocytic function of lymphocyte transformation, propagation and macrophage, improves cellular immunization and the humoral immunization ability of animal body.In the Radix Astragali, contain the compositions such as astragalus polysaccharides, flavonoid, astragaloside, aminoacid, trace element, folic acid, choline, linolenic acid, during Radix Astragali performance immunological enhancement, astragalus polysaccharides plays an important role.Astragalus polysaccharides toxicity is very low, has immunostimulant and antivirus action widely.Astragalus polysaccharides can act on cardiovascular system, and immune system has anti-stress, affects nucleic acid, improves the effects such as blood glucose.It is reported, astragalus polysaccharides is mixed and is raised ablactational baby pig and can improve material anharmonic ratio, improve daily gain, reduce diarrhea rate.
Radix Angelicae Sinensis sweet in the mouth, pungent, warm in nature, return liver, the heart, spleen channel.Main effect is for enriching blood and blood, moisturizing laxation, menstruction regulating and pain relieving.Radix Angelicae Sinensis can obviously promote Bone Morrow Hematopoietic Progenitor Cells proliferation function, strengthens erythrocyte immune ability, enhancing human body immunity power and bring into play its antitumor action.Radix Angelicae Sinensis polysaccharide in Radix Angelicae Sinensis can be by promoting spleen and hemopoietic function of bone marrow to strengthen immune function of mice.
Herba Leonuri acrid in the mouth, micro-hardship, cold nature, GUIXIN, liver, urinary bladder channel.Main effect is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.Its main chemical compositions is alkaloids, Diterpenes, phenylpropanol glycosides, volatile oil, annular polypeptide etc., and contains the various trace elements such as zinc, copper, manganese, ferrum.Can be used for treating the diseases such as involution of uterus of puerperal dairy cows is incomplete, placenta retention, lochiorrhea.R&D of modern TCM discovery, Herba Leonuri has uterine contraction, thrombolytic, anticoagulant, the blood fat reducing of promotion, falls blood viscosity, reduces erythrocyte aggregation, anticoagulant, improves all multiactions such as microcirculation, antioxidant radical and minimizing intracellular calcium overload.Herba Leonuri may also have analgesic activity by regulating cytokine to play antiinflammatory action, can be by strengthening vasculolymphatic systolic and diastolic function, and the modes such as the generation of promotion lymph fluid and backflow help the immunity of stabilizing and increasing of body recovery organismic internal environment.Gu Yueli etc. find during on the affecting of mice T, bone-marrow-derived lymphocyte at research Herba Leonuri element, and it has obvious Effect of promoting growth to caused activated T lymphocytes by concanavalin A, be use separately concanavalin A 5-8 doubly.
Poria sweet in the mouth, light, property is flat, GUIXIN, spleen, lung, kidney channel.Main effect is eliminating dampness by diuresis diuresis, spleen invigorating, mind tranquilizing and the heart calming.The pachyman containing in Poria has the effect of anti-atrophy of thymus gland, anti-splenomegaly and tumor suppression growth, both can strengthen cellular immunization, can strengthen humoral immunization again.Research discovery, pachyman can improve body condition by protecting targetedly immune organ, enhancing body anti-infection ability; Can also accelerate the recovery of hematopoietic function, improve body's immunity, health invigorating, protection bone marrow, alleviates the toxic and side effects with Prophylactic chemotherapy, plays the effect of strengthening the body resistance, spleen invigorating invigorating middle warmer.Pachyman can strengthen the phagocytic function of macrophage, can make immune organ thymus, spleen and lymph node weight increase, and can also make rosette formation rate and lymhocyte transformation rate increase.
Rhizoma Atractylodis sweet in the mouth, hardship, warm in nature, return spleen, kidney, Liver Channel.Main effect is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Can be used for distension and fullness in the abdomen, have loose bowels, inappetence, edema, beriberi flaccidity syndrome and arthralgia syndrome, anemofrigid cold, the diseases such as nyctalopia nyctalopia.Rhizoma Atractylodis not only have multiple effect to digestive system, also have protect the liver, the effect such as blood sugar lowering, antibacterial, antiviral.Research discovery, Rhizoma Atractylodis can be by regulating cytokine reach the effect that regulates immunologic function.Rhizoma Atractylodis antibacterial, antiinflammatory pharmacological action is clear and definite.
Pericarpium Citri Reticulatae acrid in the mouth, hardship, warm in nature, return spleen channel, stomach warp, lung meridian.Main effect is that in regulating qi-flowing for strengthening spleen, tune, dampness, reduces phlegm.Main containing compositions such as volatile oil, flavonoid, alkaloid, inositols in Pericarpium Citri Reticulatae.The research of Pericarpium Citri Reticulatae is not only limited to offseting system gastrointestinal tract effect research already, has related to cardiovascular, endocrine, anticancer, mutation, immunity, anti-inflammation, anti-ageing many aspects of waiting for a long time.
Fructus Crataegi sour in the mouth, sweet, warm in nature, return spleen, stomach, Liver Channel.Main effect is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Clinically for dyspepsia, do not change and postpartum stagnation stomachache the disease such as also can be used for phlegm retention, have loose bowels.In Fructus Crataegi, mainly contain flavonoid, organic acid, oligomeric flavanoid, trace element; also contain the compositions such as triterpenes, steroid and organic amine, these compositions are aid digestion with it, blood pressure lowering, blood fat reducing, antioxidation, heart tonifying, anticoagulant, immunomodulating, antibacterial, suppress distortion, give protection against cancer with to protect amphiblestroid effect closely related.Fructus Crataegi ursolic acid can significantly strengthen the phagocytic function of the immunocompromised Turnover of Mouse Peritoneal Macrophages that cyclophosphamide causes, and the leukocyte count of rising peripheral blood promotes spleen lymphocyte proliferation.After mouse subcutaneous injection Fructus Crataegi injection, can make white mice thymus and spleen weight increase, serum lysozyme content, serum coagulation antibody titre, T lymhocyte transformation rate are also all significantly improved, Thymus and spleen and humoral immunity of organism and cellular immunization are closely related, illustrate that Fructus Crataegi may all have facilitation to the humoral immunization of body, cellular immunization.
Herba Taraxaci bitter in the mouth, sweet, cold in nature, return liver, stomach warp.Main effect is heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, clearing away damp-heat, is " key medicine of antipyretic removing heat from blood ".Be used for the treatment of inflammation, constipation, stomachache, carbuncle, hyperlipidemia, tumor and prostate class disease.Modern pharmacological research discovery, Herba Taraxaci has the pharmacological action of the aspects such as broad-spectrum antiseptic, antiinflammatory, antioxidation, antitumor, blood sugar lowering, blood fat reducing, immunomodulating.Herba Taraxaci is improved and improves the effect of mouse cell immunity and non-specific immunity, the immune function of mice infringement that can help protection and recover to have ring phosphorus phthalein amine to cause.
Herba Portulacae sour in the mouth, cold in nature, return liver, large intestine channel, main effect is heat clearing away, removing heat from blood, removing toxic substances, for dysuria, and edema distension, cough due to fluid-retention, lack of appetite gastral cavity is vexed, and vomiting, has loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine, correlational study confirms that it has the effects such as anti-inflammation, antiviral, antifungal, blood fat reducing, defying age, blood sugar lowering, antitumor, enhancing immunity, antiplatelet aggregation and thrombosis.
Radix Glycyrrhizae sweet in the mouth, property is flat, returns 12 warps, and main effect is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc., pharmacological research shows, Radix Glycyrrhizae has the effects such as removing toxic substances, antibacterial, antiinflammatory, antiviral, antitumor, control hepatic injury, arrhythmia, anti-peptic ulcer, spasmolytic, inhibition airway smooth muscle cells hypertrophy, blood fat reducing and atherosclerosis, glycyrrhizic acid in Radix Glycyrrhizae has the effect of significant adrenal gland's sebum hormone sample, can be used for the enhancing of flight against senium of human body and immunity.
Source of parents therapy
The traditional Chinese medical science thinks, breast milk is directly connected to the quality and quantity of galactopoiesis by parent QI and blood, wet nurse's spirit, nutrition, health status, and nursing infant is had to the most directly impact.In breast milk (especially colostrum), contain abundant immunoglobulin, cytokine, lymphocyte, vitamin, lactoferrin, macrophage, neutrophilic granulocyte and somatomedin, can provide strong immunoprotection for piglet.Meanwhile, the large number of biological active substance in breast milk, also contributes to piglet gastrointestinal maturation and grows, and helps piglet to form healthy microbiota.
By adding Chinese medicine in sow feed, formed the basic application of source of parents therapy.Source of parents therapy is summed up from ways such as the traditional Chinese medical science " sub-disease is controlled mother ", " excessively newborn ", " making breast ", " medicine pass from breast ", and in the feedstuff of pregnancy or suckling female animal, (or in body) directly adds medicine to reach the method for control filial generation disease.This method eliminates the recessive illness of parent to a certain extent, purify milk, medicine is entered and in young animal's body, brought into play corresponding pharmacological action by milk transmission when stopping the source of infection.Research finds, after mother takes medicine most Western medicine all can metabolism in milk, nursing infant is exerted an influence.
Utilize breast milk administering mode treatment infant axillary gland tuberculosis, obtain good effect.In veterinary's production practices, by breast milk administration, be that a kind of utilization is more, remarkable in control nursery-age pig effect yellow, Hakuri.
Obviously, compared with the prior art the present invention, has advantages of adjusting, improves nursing sow health status immunologic function, that contribute to improve sow group and piglet group, helps to improve the economic benefit of raising pigs.
The specific embodiment:
Now the present invention is described in further detail in conjunction with the embodiments:
The present invention includes Radix Astragali, Radix Angelicae Sinensis, Herba Leonuri, Poria, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Fructus Crataegi, Herba Taraxaci, Herba Portulacae, Radix Glycyrrhizae.The weight consumption of each component is as shown in table 12.
Table 12
One, experimental study
By mixing, raise sow, to reach, improve sow production performance, immunologic function, and improve the Chinese medicine compound ultrafine preparation of its piglet survival rate, premunition, growth performance.The improvement of Swinery immunity function, the raising of premunition will reduce the use of the medicines such as antibiotic, and this not only can reduce costs, and also contributes to improve the food safety grade of livestock products.
1 materials and methods
1.1 material
1.1.1 trial drug
Chinese medicine compound is all purchased from Zhengzhou City Henan Province prepared slices of Chinese crude drugs company limited.The consumption of each component is as shown in table 1, is crushed to 500 order superfine powder after each component mixes, sealing, and lucifuge, deposits in dry ventilation standby.
1.1.2 experimental animal is selected and grouping
By examining healthy sow due to farrow (DABAI * length is white) facing of 50 215kg left and right, be divided at random I, II, III, IV, five groups of V, 10 every group.Each organizes sow litter (male parent is Du Luoke) because of corresponding I a, II a, III a, IV a, tri-groups of V a of being divided into of difference of sow grouping.Sow I group is matched group, and II, III, IV, V group are test group; Piglet I a group is matched group, and II a, III a, IV a, V a group are test group.
1.1.3 diet forms and trophic level
The trophic level of sow in lactation diet is pressed NRC(1998) the nutritional need preparation recommended, the feed factory preparation of practical operation Zhong Youmou company, and ensure the quality of products.
1.1.4 key instrument
Automatic blood cell calculating instrument: PE-6800VET(Shenzhen general Kanggong department);
Automatic clinical chemistry analyzer: glamour GLAMOUR1800(U.S. MD company);
Microplate reader: ELx800(U.S. Bio-Tek company);
Ultraviolet spectrophotometer: UV-VIS-8500 type (Shanghai magnificent scientific instrument company limited);
Flow cytometer: FACSCalibur(U.S. Becton Dickinson(BD) company);
Microscopy imaging system: Motic102M(Xiamen Maike Aodi Industry Group Co Ltd);
1.1.5 main agents
Routine blood test detectable, Shenzhen Pu Kang Electronics Co., Ltd.;
Biochemical index test kit, Zhong Shengbeikong biotechnology joint-stock company;
Lymphocyte separation medium (Ficol1 separating medium), Tianjin Hao Yang biological product Science and Technology Ltd.;
Pseudorabies antibody detection kit, U.S. Ai Deshi (IDEXX) company;
Immunoglobulin (IgA, IgG, IgM) ELISA test kit, upper sea blue base bio tech ltd;
Cytokine (IL-2, IL-10, TNF-α, INF-γ) ELISA test kit, upper sea blue base bio tech ltd;
Mouse-anti pig CD3FITC, CD4PE-Cy7, CD8PE fluorescent antibody, U.S. Becton Dickinson company; Erythrocyte cracked liquid (BDFACSLysingSolution), U.S. Becton Dickinson(BD) company;
Pseudorabies vaccine, the rich road (Beijing) of Pfizer animal health-care product company limited;
1.2 method
1.2.1 experimental animal is raised and Managed Solution
Test is carried out on certain pig farm, and the standard that sow feeding is strictly formulated according to pig farm is carried out.Test period is whole age of sucking (totally 21 days).Duration of test, I group is according to the arm's length standard conventional daily ration of feeding, and II group, III group, IV group, V group are fed add respectively by weight percentage the Chinese medicine compound superfine powder 1.5% of the Chinese medicine compound superfine powder 0.75% of embodiment 1 and embodiment 1, embodiment 2, embodiment 3 in feedstuff after.Duration of test, in order to guarantee medicine and quality of the fodder, mixes medicine employing and carries out on a small quantity in batches.Mix medical feed factory blender and carry out, mix that to be placed on dry ventilation standby.The feeding and management scheme strict implement that the daily management of duration of test sow and piglet is all formulated according to this pig farm.
1.2.2 the mensuration of sow and weaned piglets index
Duration of test, observes and records the searching for food of sow, spirit and health status.Each group piglet is taken to nascent body weight, 21 age in days body weight one by one, and calculate the full phase average daily gain of suckling pig (ADG).Computing formula is as follows: average daily gain (ADG)=(this age in days piglet average weight-piglet come into being average weight)/piglet age in days.
Duration of test, examines and records diarrhoea and the death condition of respectively organizing piglet.And calculate index of correlation with following formula: total number * 100% of diarrhea rate (%)=piglet diarrhea head number/piglet; Diarrhea frequency (%)=(diarrhoea number * diarrhoea natural law)/(test number * test natural law) * 100%; Mortality rate (%)=piglet dead number/piglet sum * 100%; Dead number/diarrhoea number * 100% of case fatality rate (%)=diarrhoea; Total number of Scours index=piglet stools scored sum/confession examination piglet.
Diarrhoea standards of grading: outward appearance bar shaped or granular, is chosen as 0 minute; Soft excrement, can be shaped, be chosen as 1 minute; Thick shape, shapeless, liquid dung, without segregation phenomenon, are chosen as 2 minutes; Thick shape, shapeless, liquid dung, without segregation phenomenon, are chosen as 3 minutes (Gao Jun etc., 2011).
1.2.3 routine blood test index detects
Test item mainly comprises: leukocyte count (WBC), lymphocyte ratio (LYM%), intermediate cell ratio (MID%), granulocyte ratio (GRAN%), lymphocyte number (LYM), intermediate cell number (MID), granulocyte number (GRAN), erythrocyte sum (RBC), hemoglobin (HGB), packed cell volume (HCT), platelet (PLT) etc.
1.2.4 Biochemistry test
Test item mainly comprises: total serum protein (TP), albumin (ALB), triglyceride (TG), T-CHOL (CHO), glucose (GLU), aspartate amino transferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine (CREA), lactic acid dehydrogenase (LDH) etc.
1.2.5 the detection of piglet hematid immunity function
The method that method is mainly reported with reference to people such as Wang Ling.
1.2.6 t lymphocyte subset group's detection
T lymphocyte subset group's detection is carried out at HC laboratory.During detection, take CD3+T lymphocyte as door, analyze CD4+, CD8+ cell, expression be CD3/CD4 or the expression of CD3/CD8 cell in T lymphocyte.
1.2.7 the detection of immunoglobulin, cytokine
The detection of immunoglobulin, cytokine is all carried out with ELISA test kit, and operating procedure is carried out in strict accordance with test kit operation instructions.
1.2.8 piglet pseudorabies antibody surveillance
Piglet pseudorabies antibody horizontal detects and carries out with ELISA test kit, and operating procedure is carried out in strict accordance with test kit operation instructions.
1.3 statistical analysis
Test data analyzer all adopts SPSS17.0 to carry out, and data generally adopt use
± SE represents.Application SPSS statistical analysis software one factor analysis of variance program (ANOVA) is analyzed, and carries out LSD multiple comparisons, to evaluate the significance of data difference between each group; Piglet diarrhea situation adopts x
2diversity between check evaluation group.
2 results and analysis
The impact of 2.1 Chinese medicine compound on nursing sow and weaned piglets thereof
2.1.1 sow production performance observed result
The a few days ago sow of adding Chinese medicine compound in sow feed searches for food and wants to decrease, and adds 0.75% group of sow of Chinese medicine and all can eat up reluctantly quota feedstuff, and adding 1.5% group of sow of Chinese medicine has the phenomenon that can not eat individually.Matched group can be eaten up the feedstuff of quota, but respectively organized sow since the 3rd day, all can eat up the feedstuff of quota.Duration of test, clinic observation result shows, the clinical symptom that each is organized sow production performance performance well and does not find any disease.
2.1.2 piglet growth performance testing result
In sow feed, add after Chinese medicine compound, (II a, III a, IV a, V end a) weighs two test group piglets and daily gain (ADG) all more all improves with matched group, II a group and III a, IV a, V a group have improved 5.98% left and right and 1.64% left and right compared with I a group ADG, during 21 age in days, body weight improves respectively 5.60% left and right and 4.84% left and right, but difference between each group not significantly (
p> 0.05).In Table 1.
Table 1 piglet growth performance situation
2.1.3 piglet diarrhea and death condition observed result
In sow feed, add after Chinese medicine compound superfine powder, the diarrhea rate of test group piglet, diarrhea frequency, Scours index, mortality rate all decrease.Along with the increase of compound Chinese herb dosage, piglet diarrhea rate and mortality rate have and reduce gradually trend, the diarrhea rate of III a, IV a, V a group piglet significantly decline (
p<0.05).In Table 2.
Table 2 piglet diarrhea situation
(note: a represents that (I is significant difference a) with matched group with column data acceptance of the bid
p<0.05)
The impact of 2.2 Chinese medicine compound on sow in lactation and piglet routine blood test index thereof
2.2.1 sow routine blood test index testing result
In sow feed, add after Chinese medicine compound superfine powder, nursing sow routine blood test index has obtained corresponding improvement.In sow feed, add after Chinese medicine compound superfine powder, the index such as LYM, MID, RBC, HGB and matched group significant difference in sow blood (
p<0.05), the RBC of matched group sow, HGB are lower than normal value, and prompting sow body may anemia.In Table 3.
2.2.2 piglet routine blood test index testing result
In sow feed, add after Chinese medicine compound superfine powder, nursery-age pig routine blood test index has obtained certain improvement.In sow feed, add after Chinese medicine ultra-fine powder, the index such as LYM, MID, RBC, HGB and matched group significant difference in suckling pig blood (
p<0.05), the RBC of matched group piglet, HGB, lower than normal value, point out piglet possibility anemia; GRAN, GRAN% be significantly reduced (
p<0.05).In Table 4.
The impact of 2.3 Chinese medicine compound on sow in lactation and Serum Biochemical Index in Piglets thereof
2.3.1 sow Biochemical Indices In Serum testing result
In sow feed, add after Chinese medicine compound superfine powder, sow Biochemical Indices In Serum has obtained certain improvement.Add after Chinese medicine ultra-fine powder, sow serum T P, ALB compared with matched group have significantly extremely and significantly improve (
p<0.05 or
p<0.01), AST, ALT have rising trend, but compared with matched group difference not significantly (
p> 0.05).III group sow serum BUN significantly reduce (
p<0.05), two test group sow serum TGs, CHO content all increase, but with matched group comparing difference not significantly (
p> 0.05).In Table 5.
2.3.2 Serum Biochemical Index in Piglets testing result
In sow feed, add after Chinese medicine compound superfine powder, Serum Biochemical Index in Piglets has also obtained certain improvement.After adding Chinese medicine ultra-fine powder in sow feed, its piglet serum T P, ALB are all on the rise.In earlier stage (Day 7) between two test group piglet (II a, III a, IV a, V serum T P, ALB a) all with matched group significant difference (
p<0.05), more obvious to the increase of later stage (Day 21) II a group, with matched group comparing difference significantly (
p<0.05), III a, IV a, V a group and matched group difference not significantly (
p> 0.05).Test group piglet serum AST, ALT are also on the rise, ALT and matched group comparing difference significantly (
p<0.05).Duration of test, test that two groups of piglet serum TGs, CHO and matched groups relatively have significantly or increase extremely significantly (
p<0.05 or
p<0.01).Significantly reduce the serum BUN early stage (Day 7) of III a, IV a, V a group piglet (
p<0.05), each group difference of later stage not significantly (
p> 0.05).In Table 5.
Table 3 sow routine blood test index result
(note: in the data of identical age in days, colleague's data acceptance of the bid a represents and matched group (I group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
Table 4 piglet routine blood test index result
(note: in the data of identical age in days, colleague's data acceptance of the bid a represents that (I is significant difference a) with matched group
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
Table 5 sow and piglet blood biochemistry index result thereof
(note: in identical age in days data, colleague's data acceptance of the bid a represents that (I group/I is significant difference a) with matched group
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
2.4 Chinese medicine compound are on sow in lactation and the impact of piglet hematid immunity function thereof
2.4.1 sow erythrocyte immune testing result
In sow feed, add after Chinese medicine compound superfine powder, nursing sow hematid immunity function has obtained corresponding improvement.The erythrocyte C of test group sow
3breceptor rosette rate (E-C
3brR) obtained remarkable lifting, with matched group comparing difference significantly (
p<0.05).Test group erythrocyte immune complex rosette rate (E-ICRR) has certain downward trend, but between each group comparing difference not significantly (
p> 0.05).In Table 6.
Table 6 sow erythrocyte immune result
(note: in same test item data, colleague's acceptance of the bid a represents and matched group (I group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
2.4.2 piglet erythrocyte immune testing result
In sow feed, add after Chinese medicine compound superfine powder, nursery-age pig hematid immunity function has obtained corresponding improvement.The erythrocyte C of test group piglet
3breceptor rosette rate (E-C
3brR) obtained remarkable lifting, with matched group significant difference (
p<0.05).Between each group, erythrocyte immune complex rosette rate (E-ICRR) changes not remarkable.In Table 7.
Table 7 piglet erythrocyte immune result
(note: in same test item data, colleague's acceptance of the bid a represents and matched group (I a group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
The impact of 2.5 Chinese medicine compound on sow in lactation and piglet t lymphocyte subset group thereof
2.5.1 sow t lymphocyte subset group testing result
In sow feed, add after Chinese medicine compound superfine powder, sow in lactation CD4+, CD8+, CD4+/CD8+ have certain rising trend, to test middle and late stage two test group sows and matched group sow relatively occurred significantly extremely significant difference (
p<0.05 or
p<0.01).In Table 8.
2.5.2 piglet t lymphocyte subset group testing result
In sow feed, add after Chinese medicine compound superfine powder, the CD4+ of nursery-age pig, CD4+/CD8+ all have certain rising trend.Test group piglet CD4+ compared with matched group piglet present significant difference (
p<0.05), each organize piglet CD8+ difference not obvious (
p> 0.05).In Table 8.
Table 8 sow and piglet t lymphocyte subset group result thereof
(note: in sow/piglet data, colleague's acceptance of the bid a represents and matched group (I group/I a group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
The impact of 2.6 Chinese medicine compound on sow in lactation and piglet immunological globulin thereof
2.6.1 sow Detection of immuno-protein result
In sow feed, add after Chinese medicine compound superfine powder, in sow serum, IgA, IgG, IgM all have the trend of rising.Test group sow serum IgA, IgM and matched group sow relatively occurred significantly extremely significant difference (
p<0.05 or
p<0.01); Serum IgG except the II group of later stage (Day 21), all the other times respectively organize difference not significantly (
p> 0.05).II group data are best, and 0.75% ratio Chinese medicine is added in prompting can better increase sow immunoglobulin content.In Table 9.
2.6.2 piglet immunological globulin testing result
In sow feed, add after Chinese medicine compound superfine powder, nursery-age pig Immunoglobulin IgA, IgG, IgM have certain rising trend.II a group piglet serum IgM compared with matched group piglet present significant difference (
p<0.05).III a, IV a, V a group piglet (Day 7) serum IgG in early stage and matched group piglet significant difference (
p<0.05), between each group of all the other time periods IgG difference not significantly (
p> 0.05).Between each group IgA content difference not significantly (
p> 0.05).Duration of test, the Data Representation of II a group is best.In Table 9.
Table 9 sow and piglet immunological globulin testing result thereof
(note: in sow/piglet data, colleague's acceptance of the bid a represents and matched group (I group/I a group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
The impact of 2.7 Chinese medicine compound on sow in lactation and piglet cytokine thereof
2.7.1 sow cytokines measurement result
In sow feed, add after Chinese medicine compound superfine powder, sow Cytokine of Serum IL-2, IL-10, TNF-α, INF-γ have certain rising trend.Wherein, test early stage (Day 7) test group sow serum IL-2, IL-10, TNF-α compared with matched group sow present significant difference (
p<0.05), later stage (Day 21) difference not significantly (
p> 0.05), in later stage (Day 21), in III, IV, V group sow serum INF-γ, IL-10 and matched group sow comparing difference significantly (
p<0.05).In Table 10.
2.7.2 piglet cytokines measurement result
In agent of feed for nursing sow, add after Chinese medicine compound superfine powder, nursery-age pig serum cytokines IL-2, IL-10, TNF-α, INF-γ all have certain rising trend as a whole.Wherein, the performance of III a, IV a, V a group is comparatively desirable, the majority parameters in each period all with matched group significant difference (
p<0.05).From the data of the visible two test group piglets of whole data result analysis, compared with matched group piglet, have clear improvement.In Table 10.
Table 10 sow and piglet cytokines measurement result thereof
(note: in sow/piglet data, colleague's acceptance of the bid a represents and matched group (I group/I a group) significant difference
p<0.05; Mark b represents that difference is extremely remarkable
p<0.01)
The impact of 2.8 Chinese medicine compound on nursery-age pig pseudorabies antibody horizontal
In sow feed, add after doses Chinese medicine compound superfine powder, the trend that piglet is slightly accelerated the immune response of pseudorabies vaccine, the antibody horizontal producing at same time point has the trend of increase, but difference between each group not significantly (
p> 0.05).In Table 11.
Table 11 piglet pseudorabies antibody horizontal result
3 discuss
The impact of 3.1 Chinese medicine compound on sow in lactation and weaned piglets thereof
Using Chinese herbal medicine as feed additive to improve piglet digestive tract function, to strengthen digestive enzyme activity, make animal body strengthen digesting and assimilating and anabolism nutrient, accelerate its growth promoter, the immune function, reduction diarrhea rate and the mortality rate that improve body become a study hotspot, and relevant report is a lot of.In clinical practice, breast milk administration is a kind of more medication of applying clinically.Remarkable in control nursery-age pig effect yellow, Hakuri, people cures the clinical relevant report using that also has simultaneously.By to the analysis of lot of documents and summary, we are undeniable by sow in lactation medication, and medicine can produce pharmacological action to parent on the one hand; On the other hand, because mammary gland communicates by cell with blood capillary, allly can enter sanguimotor medicine, all can enter milk, suckling process makes medicine naturally enter intestine of young pigs with milk and brings into play corresponding pharmacological action.
Result of the test shows, by adding in sow feed after Chinese medicine compound superfine powder, and sow aspect, except a few days ago feed intake is under some influence, all the other time periods are respectively organized the feed intake of sow and the clinic observation result of the mental status and have no difference.Piglet aspect, the growth performance of comparing test group piglet with matched group has improvement to a certain degree.Two test group piglet diarrhea rates, diarrhea frequency, Scours index, mortality rate are all reduced.Wherein, the diarrhea rate of III a, IV a, V a group piglet significantly declines.This is similar to the report result that the people such as Shu Qisong, Pan Chunxiu, Yan Cheng improves weaned piglets by Chinese medicine source of parents therapy.Simultaneously also can treat swinery diarrhoea with the Pingwei San of people's report such as Xu Desheng, Huang Yonghan, Wang Shijun conforms to the report that improves growth performance.
In sum, add a certain proportion of Chinese medicine compound ultrafine preparation in sow feed after, can be used for improving by source of parents factor the growth performance of piglet, and may contribute to strengthen the immunologic function of piglet and improve its resistance against diseases, make weight gain of piglets reduce again faster the generation of diarrhoea simultaneously.Testing the Chinese medicine ingredients that the multidigit containing in Chinese medicine compound ultrafine preparation used has immunoregulation effect and Nutrition, is the material base that Chinese medicine source of parents therapy improves weaned piglets.
The impact of 3.2 Chinese medicine compound on sow in lactation and piglet routine blood test index thereof
Result of the test shows, adds after Chinese medicine compound superfine powder in sow feed, and nursing sow routine blood test index has obtained corresponding improvement.Add after Chinese medicine ultra-fine powder, in sow blood, LYM, LYM%, MID, MID%, RBC, HGB etc. have obtained significant raising.In piglet blood, the content of LYM, LYM%, MID, MID%, RBC, HGB is improved.In agent of feed for nursing sow, add after Chinese medicine ultra-fine powder two test group sows and piglet LYM, MID, RBC value all higher than matched group, this is to nursing sow and piglet thereof, especially immune system is grown to also incomplete piglet and this means that body strengthens the resistance of pathogen, pigling immunity is improved, and the premunition of the piglet arriving with clinical observation improves consistent.Sow is synchronizeed and increases with piglet RBC and HGB, and prompting has improved the state of swinery anemia, and this may promote the hemopoietic function of sow and piglet and mobilize body stored blood to proceed to blood circulation with this prescription relevant.Meanwhile, the two increase also illustrates that machine vivo oxidation and substance metabolism functions are improved, and the growth performance that is conducive to piglet improves.To use Chinese medicine can improve the report of swinery routine blood test index similar to people such as Cai Jingyi, Kong Xiangfeng, Hua Ying for this.
In sum, in sow feed, add the routine blood test index that can improve sow and piglet thereof after a certain proportion of Chinese medicine compound ultrafine preparation, the mechanism of action may be that the improvement of routine blood test index is body health situation and the improved performance of immunologic function because the effective ingredient in Chinese medicine compound can play the effect that regulates body hematopoietic function.The stilbene Herba Leonuri soup of returning in compound recipe is all empty good recipes for the treatment of QI and blood, has that QI invigorating is enriched blood, the effect of nourshing blood and promoting blood circulation, and the improvement of test group sow and piglet routine blood test index may be relevant with its effect.
The impact of 3.3 Chinese medicine compound on sow in lactation and Serum Biochemical Index in Piglets
The discovery of this result of the test is added after Chinese medicine compound superfine powder in sow feed, and the Biochemical Indices In Serum of sow in lactation and piglet thereof has all obtained corresponding improvement.Two test group piglet serum ASTs, ALT, TP, ALB, TG, CHO have growth trend, and GLU, BUN decline to some extent, and the facts such as the piglet growth performance raising that this just in time obtains with clinical observation, diarrhea rate reduction are consistent.Add the change of serum C HO of four groups of sows of Chinese medicine and piglet thereof and TG content all higher than or be significantly higher than matched group, show that this Chinese medicine compound ultrafine preparation can help improve the lipid metabolism of body, make more fat oxidation, provide body synthetic protein required energy, with two test group weight gain of piglets faster observed result conform to.Increasing with the people such as Wu Gemin of test group piglet AST, ALT becomes positively related report consistent about serum AST, ALT content with the assorted weight gain of piglets of DLY ternary.Relatively there is obvious rising trend in the sow after interpolation Chinese medicine and piglet serum T P, ALB and matched group, illustrate that add after Chinese medicine can be in the protein metabolism level of to a certain degree improving sow in lactation and piglet thereof, and can contribute to the raising of sow in lactation and piglet immunological function thereof.Test group piglet change of serum C HO, TG content are all higher than matched group, and showing to add Chinese medicine ultra-fine powder compound recipe may increase pig fat deposition.Meanwhile, the decline of test group piglet BUN and GLU, shows that the precipitation of protein is strengthened, and the conversion of glucose and utilization ratio increase, and this also improves the fact faster with test group piglet growth performance and conforms to.
In sum, in sow feed, add the Biochemical Indices In Serum that can improve sow and piglet thereof after Chinese medicine compound superfine powder.Be conducive to improve the material energy metabolism of pig body, help to improve its fertility performance, can improve Anemia situation, and can strengthen swinery body constitution and resistance against diseases to a certain extent.
The impact of 3.4 Chinese medicine compound on sow in lactation and piglet hematid immunity function thereof
This result of the test shows, adds after Chinese medicine compound superfine powder in sow feed, and sow and piglet hematid immunity function thereof have all obtained corresponding improvement.The erythrocyte E-C of sow and piglet
3brR rosette rate is all significantly improved, with matched group significant difference.Sow erythrocyte E-ICRR rosette rate has certain downward trend, but group difference is not obvious; It is also not obvious that each organizes piglet erythrocyte E-ICRR rosette rate variation tendency.To use Chinese medicine to improve the report result of swinery hematid immunity function similar to the people such as Wang Ling, Zhong Nina, Pu Wanxia for this.
In sum, in sow feed, adding Chinese medicine compound superfine powder can be by improving sow in lactation and piglet erythrocyte E-C thereof
3brR rosette rate, reduces erythrocytic E-ICRR rosette rate, and plays the effect of the hematid immunity function that improves sow and piglet thereof.The effect that this QI invigorating that may have with prescription is enriched blood is relevant, its mechanism may be mixed and raise the ability that can improve sow and piglet red blood cell adhesion immune complex thereof after sow in lactation with Chinese medicine compound superfine powder, can remove timely and effectively the reasons such as immune complex relevant.
The impact of 3.5 Chinese medicine compound on sow in lactation and piglet t lymphocyte subset group thereof
Result of the test shows, adds after Chinese medicine compound superfine powder in sow feed, and sow in lactation CD4+, CD8+, CD4+/CD8+ are necessarily raise; Test group piglet CD4+, CD4+/CD8+ are also necessarily promoted, and each variation tendency difference of organizing CD8+ between piglet is not obvious.This conforms to the report that the people such as Zheng Dongcai, Xu Desheng uses Pingwei San or Pingwei San plus-minus to improve body T lymphocyte value, also to use Chinese medicine to improve the report of the thin subgroup ratio of animal body T lymph similar to Xie Hongbing, square such as happy Kun, the people such as Lv Sucheng also think that pachyman has very strong facilitation to cellular immunization, can adjust the ratio of T cell subsets especially, enhancing human body immunity function, improves body health situation.Meanwhile, other Chinese medicine ingredients in compound recipe also may be by dependent interaction to play the effect that strengthens T lymphocyte function.
In sum, add Chinese medicine compound superfine powder in sow feed after, t lymphocyte subset group is had a certain impact, this Chinese medicine compound has the effect that strengthens sow and piglet cellular immune function thereof, in actual production practice, can be used for improving sow in lactation and piglet immunological function thereof.Its mechanism is likely owing to adding in sow in lactation feedstuff after Chinese medicine compound superfine powder, and middle the effective elements of the medicine, in vivo by integrally-regulated and local action, has played the effect that regulates T lymphocyte correlation function, needs further to be studied.
The impact of 3.6 Chinese medicine compound on sow in lactation and piglet cytokine thereof
Result of the test shows, adds after this Chinese medicine compound superfine powder in sow feed, and nursing sow and piglet Cytokine of Serum IL-2, TNF-α, INF-γ have certain rising trend.The beautiful outstanding people of this and beam waits the strengthening spleen, tonifying kidney of report can enhancing body IL-2 expression, astragalus polysaccharides, Radix Angelicae Sinensis polysaccharide and pachyman can enhancing body IL-2 expression, the expression that astragalus polysaccharides, Radix Angelicae Sinensis polysaccharide, Taraxacum Polysaccharides can improve body TNF-α, Radix Angelicae Sinensis polysaccharide, pachyman can promote that the results of study such as body INF-γ secretion are similar.In test group sow and piglet serum, IL-2 and INF-γ and matched group comparing difference are remarkable, may point out swinery cellular immune function to be improved.The test data performance of III, IV, V group sow and III a, IV a, V a group piglet is comparatively desirable, and 1.5% ratio Chinese medicine compound superfine powder effect is added in prompting may be better.
In sum, by the analysis to test data, discuss, prove and in agent of feed for nursing sow, add after this Chinese medicine compound superfine powder, the cytokine levels of test group sow and piglet thereof improves, and illustrates that to a certain extent body's immunity is improved.Because this test is not done pharmacokinetics test to Chinese medicine, the effect that therefore will really illustrate this Chinese medicine compound growth-promoting cytokine, also needs the multi-disciplinary hand-in-gloves such as pharmacology, chemistry, biology.
The impact of 3.7 Chinese medicine compound on sow in lactation and piglet immunological globulin
Result of the test shows, adds after Chinese medicine compound superfine powder in sow feed, and in nursing sow and piglet serum thereof, IgA, IgG, IgM all have certain rising trend.This uses the result of study of Chinese medicine raising immunoglobulin content similar to the people such as Chen little Bo, what justice, Li Heping, Wang Lin.Later stage, increases to have reduced and inhales breast amount because piglet starts material feeding, has reduced the amount that absorbs related immune enhancing substance from breast milk, and each organizes piglet immunological globulin content, and the difference between decline and matched group and test group is no longer obvious to some extent.Thereby this has proved the humoral immunization function that medicinal herb components may affect breast milk and affect the content raising piglet of piglet immunity of organism globulin by suckling from the side.
In sum, in sow in lactation feedstuff, add after a certain amount of this Chinese medicine compound superfine powder and can play to a certain extent the effect that improves nursing sow and piglet Immunoglobulin in Serum content thereof, contribute to improve the humoral immune function of pig body.This compound recipe can reach increase the content of immunoglobulin be with compound recipe in the immunological enhancement of multidigit Chinese medicine closely-related, it may be single component effect, also may be the synergism of several compositions, concrete mechanism also needs further to inquire into by tests such as Chinese medicine pharmacokineticss.
The impact of 3.8 Chinese medicine compound on nursery-age pig pseudorabies antibody horizontal
Result of the test shows, add Chinese medicine compound superfine powder in sow in lactation feedstuff after, to have certain help animal body to produce the function of antibody, has certain effect on antibody generation time and antibody horizontal, but difference between group is not remarkable.This compound recipe can to a certain degree improve antibody horizontal, may have to Pingwei San in compound recipe that to improve the function of bone-marrow-derived lymphocyte relevant, and in compound recipe, the plurality of Chinese composition such as astragalus polysaccharides also has the effect that strengthens B cell function simultaneously.Pachyman has the effect that promotes vaccinum influenzae inactivatum immune effect, and this prompting pachyman may promote for the immunological adjuvant of pseudorabies vaccine the immune effect of vaccine.Studies show that; astragalus polysaccharides, except itself having enhancing human body immunity power, can also make the immunity of vaccine greatly strengthen, and vaccine is had to good protection effect; and can make vaccine effect tire to promote to accelerate and improve the level of tiring, can also promote colony's horizontal regularity of tiring.Also may there is similar function by other compositions of herbal mixture, wait further research.
4 conclusions
Test by adding different proportion Chinese medicine compound superfine powder a period of time in sow feed, observed and recorded sow and weaned piglets index thereof, and extract sow weekly and piglet blood is done immune index detection, the clinical application effect with this to this compound recipe is assessed.
Result shows, adds the sickness rate that Chinese medicine compound ultrafine preparation can improve the fertility performance of suckling pig and reduce diarrhoea in sow feed; Can improve Anemia situation; Can improve to a certain extent the hematid immunity function of sow and piglet thereof; Can improve partial immunity globulin and the cytokine content of sow and piglet thereof; Can improve the t lymphocyte subset group percentage ratio of sow and piglet.Presentation of results, is used the said preparation can be by improving the effects such as cellular immunization, humoral immunization, erythrocyte immune, carrys out the immunologic function of comprehensively regulating body from specific immunity and nonspecific immunity, improves body fertility performance and resistance against diseases.
Claims (1)
1. source of parents therapy is improved a Chinese medicine preparation for nursing sow and piglet health status thereof, it is characterized in that by weight content being that the Radix Astragali of 12-28 part, the Radix Angelicae Sinensis that weight content is 3.75-8.75 part, the Herba Leonuri that weight content is 7.5-17.5 part, the Poria that weight content is 6-14 part, the Rhizoma Atractylodis that weight content is 6-14 part, the Pericarpium Citri Reticulatae that weight content is 3.75-8.75, the Fructus Crataegi that weight content is 6-14 part, the Herba Taraxaci that weight content is 6-14 part, the Herba Portulacae that weight content is 6-14 part, the Radix Glycyrrhizae that weight content is 3-7 part form.
2. source of parents therapy according to claim 1 is improved the Chinese medicine preparation of nursing sow and piglet health status thereof, it is characterized in that Chinese medicine preparation makes mixture, granule, superfine powder.
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| CN102919607B (en) * | 2012-11-14 | 2013-08-21 | 韶关金苹果饲料有限公司 | Chinese herbal medicine compound feed additive with anti-diarrhea function and improving pork quality |
| CN103829043A (en) * | 2012-11-20 | 2014-06-04 | 四川铁骑力士实业有限公司 | Chinese herbal medicine additive for prevention of diarrhoea of piglets and its preparation method |
| CN103404695A (en) * | 2013-07-12 | 2013-11-27 | 镇江万山红遍农业园 | Traditional Chinese medicine additive for improving milk yield of nanny goat and using method thereof |
| CN103749994A (en) * | 2013-12-04 | 2014-04-30 | 华南农业大学 | Traditional Chinese medicine composition for controlling piglet diarrhea, and preparation method and application thereof |
| CN105076770A (en) * | 2015-08-05 | 2015-11-25 | 马宗彦 | Milking sow feed and preparation method thereof |
| CN106889331B (en) * | 2017-02-28 | 2019-11-15 | 广州广力莱生物科技有限公司 | A kind of pregnant sow premixed feed |
| CN108853161A (en) * | 2018-07-16 | 2018-11-23 | 广东新科农生物科技有限公司 | Application of the Moringa in the drug that preparation improves brood health by maternal effect |
| CN110810633A (en) * | 2019-11-19 | 2020-02-21 | 宁夏大北农科技实业有限公司 | Health product for postpartum sows and use method thereof |
| CN111588773B (en) * | 2020-04-23 | 2022-02-08 | 浙江理工大学绍兴生物医药研究院有限公司 | Traditional Chinese medicine composition for preventing and treating newborn piglet diarrhea through sow medicine taking and application thereof |
| CN113508871A (en) * | 2021-08-09 | 2021-10-19 | 黑龙江省农业科学院畜牧研究所 | Natural plant additive for improving reproductive performance of sows and preparation method thereof |
| CN114848763B (en) * | 2022-03-25 | 2023-05-23 | 河南牧业经济学院 | Traditional Chinese medicine composition for sow gestation period and/or lactation period, fermented traditional Chinese medicine preparation and preparation method thereof |
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| JP2006333845A (en) * | 2005-06-06 | 2006-12-14 | Unitika Ltd | Compounding agent for fodder |
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