CN102894229B - Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof - Google Patents
Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof Download PDFInfo
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- CN102894229B CN102894229B CN201210407031.XA CN201210407031A CN102894229B CN 102894229 B CN102894229 B CN 102894229B CN 201210407031 A CN201210407031 A CN 201210407031A CN 102894229 B CN102894229 B CN 102894229B
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Landscapes
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Abstract
The invention provides a natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation. The natural feed additive is formed by main drugs and optional auxiliary materials, wherein the main drugs comprise the components in parts by weight: 5-40 parts of geranium wilfordii, 5-40 parts of houttuynia cordata, 2-15 parts of garden burnet, 2-35 parts of gallnut, 2-20 parts of radix berberidis or golden cypress and 1-20 parts of liquorice, and 0.5-10 parts of radix scutellariae, 1-8 parts of perfoliote knotweed herb, 5-10 parts of pileostegia viburnoides, 2-30 parts of purslane and 2-18 parts of cortex acanthopanacis (root, stem and/or leaf) can be added to the main drugs. The feed additive can be used for preventing or treating the respiratory diseases or enteric diseases of the domestic animals, especially the pneumonia or dysentery.
Description
Technical field
Patent of the present invention relates to feed additive field, specifically, provides a kind of natural feed addictive with antidiarrheal antibacterial and anti-inflammation functions.Patent of the present invention also relates to the preparation method of this natural feed addictive.
Background technology
Domestic birds and animals, as infected the diseases such as breathing problem, pneumonia, enteritis, dysentery, can cause very large economic loss to raiser.Traditional feed addictive generally adds the antibiosis such as Enrofloxacin, Ciprofloxacin or Ofloxacin usually to prevent and treat diseases of bird and livestock, easily residues in meat, and human body is produced to adverse effect.Along with the raising of people's living standard, pork, chicken, beef that has antibiotic residue etc. is not more and more accepted by common people, in the world today many countries to should being used as of antibiotic and chemicals additive progressively eliminate or the regulation that bans use of, the choice meat goods of safety that popular required is, healthy, antibiotic-free.Therefore, seek nonreactive, noresidue, green, health, the novel fodder additive with antidiarrheal antibacterial and anti-inflammation functions is imperative.
Chinese herbal medicine and natural plants immunity substance mass-energy enhanced machine body immunity function, have the clinical use basis of more than one thousand years.Along with further going deep into of modern scientific research work, research find Chinese herbal medicine and part natural products have the animal of raising anti-stress, antiviral ability, can improve animal meat and production performance, nontoxic, noresidue, have good theoretical foundation and great application prospect by Chinese herbal medicine and natural products for developing the novel fodder additive of nonreactive.And the development of Chinese herbal feed additive is at present mostly only take ancient prescription Chinese traditional medicine as basis, directly after the simple processing of pulverizing, use, there is dosage greatly and lack the shortcomings such as farm breeds theoretical foundation.
Although the exploitation of current pure Chinese herbal feed additive makes some progress, but every kind of product is all pluses and minuses and deposits, and when comparing with antibiotic, pure Chinese herbal feed additive generally seems that onset is slow, resistant effect is not strong, potency ratio does not have advantage, in present feed additive field, does not also set up irreplaceable status.
Summary of the invention
The object of the present invention is to provide that a kind of bioavilability is high, consumption is few, instant effect, effective, stability is high, mechanism of action is clear and definite, there is antidiarrheal antibacterial and anti-inflammation functions, can be used for prevention and treatment domestic birds and animals breathing problem, pneumonia, antidiarrheal, prevent and treat the natural feed addictive of dysentery, containing antibiotic, hormone and chemicals, to solve the shortcoming in above-mentioned background technology.
Another object of the present invention is to provide preparation method and the purposes of this feed addictive.
Technical scheme of the present invention is as follows:
The invention provides a kind of natural feed addictive with antidiarrheal antibacterial and anti-inflammation functions, by main ingredient and the optional auxiliary material existing, formed, it is characterized in that, described main ingredient is by geranium wilfordii, cordate houttuynia, garden burnet, Chinese gall, radix berberidis or golden cypress, and Radix Glycyrrhizae composition, by weight, 5～40 parts of geranium wilfordiis, 5～40 parts of cordate houttuynias, 2～15 parts of garden burnets, 2～35 parts, Chinese gall, 2～20 parts of radix berberidis or golden cypresses, 1～20 part, Radix Glycyrrhizae.
Feed addictive described above, main ingredient wherein can also add 0.5～10 part of the root of large-flowered skullcap, 1～8 part of polygonum perfoliatum, 5～10 parts, official hats and canopies rattan, 2～18 parts of 2～30 parts of purslanes and cortex acanthopanacis (root, stem and/or leaf), described umber is weight portion.
Preferably, the invention provides a kind of feed addictive described above, main ingredient is wherein: 14 parts of geranium wilfordiis, 23 parts of cordate houttuynias, 20 parts of garden burnets, 17 parts, Chinese gall, 20 parts of radix berberidis or golden cypresses, 6 parts, Radix Glycyrrhizae.
Preferably, the invention provides a kind of feed addictive described above, main ingredient is wherein: 10 parts of geranium wilfordiis, 12 parts of cordate houttuynias, 14 parts of garden burnets, 12 parts, Chinese gall, 12 parts of golden cypresses, 4 parts, Radix Glycyrrhizae, 4 parts of the roots of large-flowered skullcap, 6 parts of polygonum perfoliatums, 6 parts, official hats and canopies rattan, 8 parts of 12 parts of purslanes and cortex acanthopanacis (root, stem and/or leaf).
The feed addictive that the present invention is described above, optionally contains auxiliary material, i.e. 0～52 part of auxiliary material wherein, and auxiliary material can be one or more of wheat bran, rice bran, dextrin, starch, inferior powder.
The feed addictive that the present invention is described above, has definite antidiarrheal, antibacterial or antiinflammation, can be used for disease, particularly pneumonia or the dysentery of prevention or treatment domestic birds and animals respiratory tract or enteron aisle.Described poultry can be for example laying hen, broiler chicken, duck, goose, pigeon; Described domestic animal can be for example pig, ox, sheep.
The present invention also provides the preparation method of natural feed addictive described above, it is characterized in that:
A, geranium wilfordii, garden burnet, Chinese gall, barberry, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane, cortex acanthopanacis (root, stem, leaf), golden cypress, with solvent extraction, collect extract after difference or mixing, and removal solvent obtains extract;
B, cordate houttuynia, the flash extraction of water, collects extract, removes solvent and obtains extract;
C, step a and b be extract obtained is dried to dry cream, pulverizes, and optionally adds auxiliary material, mixes and get final product.
Or, the natural feed addictive that the present invention is described above, its preparation method is:
A, cordate houttuynia are extracted volatile oil, and volatile oil is made to cyclodextrin inclusion compound, and the dregs of a decoction save backup;
B, geranium wilfordii, garden burnet, Chinese gall, barberry, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane, cortex acanthopanacis (root, stem, leaf), golden cypress, together with the dregs of a decoction that obtain in step a, after difference or mixing, with solvent extraction, collect extract, removal solvent obtains extract;
C, step b be extract obtained is dried to dry cream, pulverizes, and optionally adds auxiliary material, adds the cyclodextrin inclusion compound in step a to mix and get final product.
The natural feed addictive that the present invention is described above, is directly used after also can medicinal raw material pulverizing, and is about to described main ingredient medicinal material and pulverizes separately or after mixing, optionally adds auxiliary material, after mixing and get final product.
In feed addictive of the present invention, the official hats and canopies rattan of using, it is Saxifragaceae official hats and canopies Calamus plant official hats and canopies rattan (Pileostegiavibumoides Hook.f.et Thoms.), calls and adds rattan, the large rope of monkey for Radix Pileostegiae viburnoidis, bamboo fiber crops, hedgehog hydnum rattan, paper.Domestic Anhui, Zhejiang, Jiangxi, Hunan, Hubei Province, river, Guizhou Province, Fujian, platform, Guangdong, osmanthus, Yunnan, the fine jade area of being mainly distributed in.The function and usage of official hats and canopies rattan is mainly dispels rheumatism, promoting blood circulation to remove blood stasis, swelling and pain relieving, synthetism; Root and stem are for waist and leg ache, rheumatic numbness.Traumatic injury is controlled in external application, fracture, traumatism and bleeding, sore.The official hats and canopies rattan that the present invention uses can be root, stem, leaf partly or entirely.
In the present invention's feed addictive preparation method described above, solvent extraction solvent used can be the ethanol of water or variable concentrations, for example, can be the concentration ethanolic solution that is 50%.
In the present invention's feed addictive preparation method described above, described extraction can adopt one or more in heating and refluxing extraction method, ultrasonic extraction, Microwave Extraction method and flash extraction method.
Flash extraction is a known extractive technique in traditional Chinese medicine extraction field, it relies on high speed machine shearing force and super moving molecule diafiltration technology, in the presence of room temperature and solvent, in the several seconds, plant material is crushed to fine particle, and make active ingredient reach rapidly prevention internal and external equilibrium, by filtration, reach the object of extraction.This extracting method can retain effective ingredients in plant to greatest extent, can not be subject to heat damage, has the advantages such as normal temperature extracts, solvent load is few, extraction time is short, efficiency is high, operating procedure is simple.
In feed addictive preparation method of the present invention, extract is dried to dry cream, wherein dry can use ovens dry, spraying to be dried and micro-wave vacuum in one or more.
Micro-wave vacuum is that one is placed in material under condition of negative pressure, and after suitably being reached the boiling point under negative pressure state or by cooling, material is solidified by heating using microwave, by molten point, carrys out the drying mode of dried material.Because the heating using microwave of this utilization is a kind of radiation heating, that microwave is directly had an effect to object, make to be heated inside and outside it simultaneously, need not carry out transferring heat by convection current or conduction, so firing rate is fast, the thermal efficiency is high, the processing time is short, material inside and outside temperature is even, there is the saving energy, drying efficiency is high, and dry mass is good, the active ingredient advantage such as be not destroyed.
The above-mentioned feed addictive of the present invention is the 0.1-0.3% of daily ration ratio for the RD of domestic birds and animals.
The advantage of patent of the present invention: the natural feed addictive raw material of patent of the present invention is all from natural Chinese medicinal herb, nature and the biologically active of various constituent structure have been kept, useful and harmless to humans and animals, and through science, concocted and remove harmful part before application, keep pure natural sex, aspect control diseases of bird and livestock, having unique advantage.Toxic and side effect and the drug resistance of traditional chemicals, antibiotic and hormone easily cause animal product medicament residue, and this has become the problem that a whole society pays close attention to.The toxic and side effect of this natural feed addictive is little, can avoid " three cause " (mutagenesis, teratogenesis, carcinogenic), residual and drug resistance problem, can specificity or non-specifically strengthen the immunity of animal body, be a unique advantage of this additive, this is that existing product is incomparable.The present invention is except antidiarrheal, and outside dysentery, the effect of each Chinese medicine material is collaborative mutually, and makes it to produce omnibearing coordinative role and the entirety transfer effect to body advantage factor, also can improve the tender degree of lean pork rate, reduction percentage of water loss, raising meat.Preparation technology of the present invention is relatively simple, produces free from environmental pollutionly, and various chemical constitutions and biologically active are stable, and accumulating is convenient, not perishable.The present invention is except direct pulverizing is used, and the preparation method who provides in invention can reduce the consumption of additive, has that bioavailability is high, an instant effect, good absorbing, good stability, can feed or drinking-water administration for direct spice, easy to use.
The specific embodiment
Below by specific embodiment, further set forth the present invention.
Embodiment 1
Press row weight proportion and take raw material (Kg):
Geranium wilfordii 14 cordate houttuynia 23 garden burnets 20
Chinese gall 17 radix berberidis 20 Radix Glycyrrhizaes 6
Preparation method is:
(1), get geranium wilfordii, garden burnet, Chinese gall, barberry, Radix Glycyrrhizae mixing, with 30% ethanolic solution heating extraction 2 times, each 2 hours, extract solid-liquid ratio 8: 1, collect extract and reclaim ethanol and obtain mixed alcohol extract, gained alcohol extract continues reduced pressure concentration, dries at 60 ℃, must mix medicinal extract, be crushed to 80 order micro mists;
(2), get cordate houttuynia, the ultrasonic extraction twice of water, each 30 minutes, extract solid-liquid ratio 10: 1, collect extract, reduced pressure concentration, through micro-wave vacuum, obtains houttuynia extract powdered extract, is crushed to 80 order micro mists;
(3), by above-mentioned two step gained raw materials, mix, packing is up to the standards.
Embodiment 2
Press row weight proportion and take raw material (Kg):
Geranium wilfordii 14 cordate houttuynia 23 garden burnets 20
Chinese gall 17 golden cypress 20 Radix Glycyrrhizaes 6
Preparation method is:
(1), get geranium wilfordii, garden burnet, Chinese gall, golden cypress mixing, with 50% ethanolic solution heating extraction 2 times, each 2 hours, extract solid-liquid ratio 8: 1, collect extract recovery ethanol and obtain mixed alcohol extract, gained alcohol extract continues reduced pressure concentration, and spraying is dry, must mix medicinal extract, be crushed to 80 order micro mists;
(2), get cordate houttuynia, the flash extraction method of water is extracted 3 times, each 3 minutes, extract solid-liquid ratio 12: 1, collect extract, reduced pressure concentration, through micro-wave vacuum, obtains houttuynia extract powdered extract, is crushed to 80 order micro mists;
(3), by Radix Glycyrrhizae drying and crushing to 80 order micro mist;
(4), by above-mentioned three step gained raw materials, mix, packing is up to the standards.
Embodiment 3
Press row weight proportion and take raw material (Kg):
Geranium wilfordii 14 cordate houttuynia 23 garden burnets 20
Chinese gall 17 radix berberidis 20 Radix Glycyrrhizaes 6
Preparation method is:
(1), screening: remove the impurity in raw material;
(2), batching: take raw material by said ratio;
(3), pulverize: the raw meal being up to the standards is broken into fine powder;
(4), mix: by consumption, the fine powder after pulverizing is mixed;
(5), the packing that is up to the standards.
Embodiment 4
Press row weight proportion and take raw material (Kg):
Geranium wilfordii 10 cordate houttuynia 12 garden burnets 14
Chinese gall 12 golden cypress 12 Radix Glycyrrhizaes 4
The root of large-flowered skullcap 4 polygonum perfoliatum 6 purslanes 12
Official hats and canopies rattan 6 cortex acanthopanacis (root, stem, leaf) 8
Preparation method is:
(1), by proportioning, get cordate houttuynia, be ground into meal, extract volatile oil, volatile oil is made to cyclodextrin inclusion compound, the dregs of a decoction save backup;
(2), by proportioning, get geranium wilfordii, garden burnet, Chinese gall, golden cypress, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane, cortex acanthopanacis (root, stem, leaf), golden cypress, be ground into meal, together with the dregs of a decoction that obtain in step (1), after difference or mixing, with solvent extraction, collect extract recovery solvent and obtain extract;
(3), extract obtained continuation reduced pressure concentration, dry, get dry extract;
(4), dried cream powder is broken, together with the cyclodextrin inclusion compound instrument in step (1), mixes, and crosses 80 mesh sieves, the packing that is up to the standards, gets product.
By clinical zoopery and standardized farm breeds, beneficial effect of the present invention is described below.Mainly take the pig of different growing stages as research object, investigate the effects such as antibacterial, the anti-inflammatory of the present invention in the diseases such as prevention and treatment diarrhea of pigs and enteritis, respiratory tract infection, antidiarrheal, with and impact on fowl poultry growth performance and immunocompetence.
The impact of experimental example 1 on sow in lactation and piglet
Take milking sow as research object, by carrying out contrast experiment with colistin sulfate and the published invention of part, investigate the present invention in the impact on aspects such as lactation gain in weight, feed intake, survival rate, Scours index, blood parameters, further illustrate the beneficial effect of the present invention at aspects such as antibacterial, antidiarrheal.
One material and method
1, experimental animal and grouping
Totally 5 groups of sows (Landrace xYorkshire), every group is repeated 10 times, for 50 of examinations, from childbirth, after 10 days, give test feed, in point puerperium to carry out feeding experiment till breast is after 1 week, experimental design is (1), Normal group (CON, basal diet), (2), positive controls (PC, basal diet+0.01% colistin sulfate (antibiotic)), (3), control group HE1 (basal diet+2% Chinese herbal medicine formula 1 (CN101066313B, 2011.04.20)), (4), control group HE
2(basal diet+2% Chinese herbal medicine formula 2 (CN101584745A, 2009.11.25)), (5), test group HE (basal diet+0.2% embodiment of the present invention 1 feed addictive), point puerperium by 10 of piglet uniform distributions to each repetition sow.
2, test feed and feeding and management
Test feed is according to NRC (1998) [Nutrient requirements of domesticanimals, NO.2.Nutrient requirements of swine.Ninth revised edition.National Academy of Science.Washington.D.C.] required amount, take corn one dregs of beans as basic daily ration, the scheme giving according to agent of feed for nursing sow, respectively at sooner or later carrying out restricted giving, water can freely absorb.
3, research index and method
(1) gain in weight, feed intake, survival rate, Scours index (milking sow) be for gain in weight, when starting (during childbirth) and weigh while finishing, and calculating.Feed intake aspect, when measuring body weight, administered dose deducts residual quantity and obtains.Survival rate aspect, when starting, determine the sum of piglet every day, for calculating.Diarrhoea generation aspect, in day on-test, measures for 3,6,9 and 12 days, after newborn 1 week, also measures..
(2) blood biochemical is learned index (milking sow)
For the blood biochemical of suckling pig, learn index, when finishing (from breast time), each repetition is selected arbitrarily 3, from jugular vein blood sampling 2mL, study leucocyte (WBC), red blood cell (RBC), Immunoglobulin IgG and lymphocyte with automatic hematology analyzer.
(3) milking sow rectal temperature, carries on the back waist and oestruses after breast
For all sows, in (childbirth) and while finishing (from breast time) measure back of the body waist thickness, adopt the waist that digital back fat instrument mensuration is 5cm apart from the center line at 3 positions of Section 1 and Section 10 rib and lumbar vertebrae thick, get the average of 3 values; The temperature of rectum, (during childbirth) and when end when starting (from breast time), measures with rectal thermometer; Calculating is from breast day to the number of days of oestrusing.
(4) milking sow blood biochemical is learned index
The content of the associated hormone in milking sow blood in (childbirth) and while finishing (from breast time), take all sow blood 2mL with heparin tube, 4 ℃ with 3000rpm centrifugation 15 minutes, the research of automatic biochemical Epidemiological Analysis instrument cortisol, adrenaline and Norepinephrine content for serum.
(5) digestibility of nutriment (milking sow)
For measuring the digestibility of nutriment, ight soil while taking to finish as sign material, in adopting excrement before 5 days, adds 0.2%Cr in feed
2o
3.The ight soil of taking is dried 72 hours in 60 ℃ of air driers, pulverizes, and the Cr that the general composition of feed and sign material mix analyzes according to AOAC standard.
4, statistical analysis
Utilize the general linear model of SAS, with the processing of Duncan duncan's new multiple range method, try to achieve mean value difference.
Result and discussion
1, production performance
In feed, add when of the present invention, as shown in table 1 on the impact of suckling pig production performance.
For suckling pig Scours index, CON group is than HE1, HE2 and the significantly rising (P < 0.05) of HE group, for age at weaning Scours index, CON group is significantly higher than HE2 and HE group (P < 0.05) with HE1, the present invention, aspect body weight, daily gain, day feed intake and survival rate, all has obvious improvement.
The impact of table 1 feed addictive on piglet growth performance and antidiarrheal
| ? | CON | PC | HE1 | HE2 | HE | SE |
| Initial body weight/kg | 1.32 | 1.45 | 1.34 | 1.42 | 1.57 | 0.11 |
| Weanling weight/kg | 5.64 | 6.37 | 6.21 | 6.35 | 6.59 | 0.38 |
| Daily gain/g | 206 | 234 | 232 | 235 | 239 | 15 |
| Day feed intake/g | 105 | 115 | 96 | 104 | 89 | 18 |
| Survival rate/% | 92.96 | 97.72 | 95.63 | 95.42 | 97.23 | 3.10 |
| Lactation diarrhea rate/% | 9.75 | 5.00 | 2.75 | 3.25 | 2.25 | 3.30 |
| Age at weaning diarrhea rate/% | 6.00 | 4.00 | 5.75 | 2.75 | 1.75 | 1.92 |
| Experimental period disease incident | 7.15 | 3.24 | 6.58 | 6.29 | 3.71 | 1.43 |
Milking sow blood biochemical learn index, rectal temperature, back of the body waist and from oestrusing after breast, nutrient digestion rate is aspect dry, nitrogen, energy digestion, each group without significant difference (P > 0.05).
Comprehensive this experimental result of analyzing, additive of the present invention is for milking sow, can strengthen sow body immunity, obviously promote piglet growth, increase daily gain, reduce a day feed intake, obviously improve feed efficiency, improve survival rate, reduce lactation and age at weaning Incidence of Diarrhea, to the obvious inhibitory action that has of the other diseases such as respiratory tract pneumonia.
Experimental example 2: to the effect from newborn piglet
One materials and methods
1, experimental animal and grouping
3 yuan of cenospecies (Landrace xYorkshire xDuroc) are from 250 of newborn piglets, during on-test, body weight is 10.03 ± 0.5 ground, feeding experiment has been carried out 4 weeks, experimental design is (1), normal group (CON, basal diet), (2), positive controls (PC, basal diet+0.01%.01% colistin sulfate (antibiotic)), 3), control group HE
1(basal diet+2% Chinese herbal medicine formula 1 (CN101066313B, 2011.04.20)), (4), control group HE
2(basal diet+2% Chinese herbal medicine formula 2 (CN101584745A, 2009.11.25)), (5), totally 5 groups of test group HE (basal diet+0.2% feed addictive of the present invention), every group is repeated 5 times, every repetition is 10.
2, test feed and feeding and management
In this feeding experiment, feed is supplied with by criteria limit, and water, by self water feeding machine, can freely be drunk.
3, research index and method
(1) weightening finish method, feed intake and feed efficiency
About for gain in weight, when starting (14 days) and while finishing (28 days) measure the body weight of each group.
About feed intake aspect, when measuring body weight, feed administered dose deducts residual quantity.
About feed efficiency, gain in weight is divided by feed intake.
(2) digestibility of nutriment
For measuring the digestibility of nutriment, when taking test (14 days) and finishing, take ight soil, as sign material, in adopting excrement first 5 days, in feed, add 0.2%Cr
2o
3.The ight soil of taking is dried to 72 hours in 60 ℃ of air driers, pulverizes, the general composition of feed and the Cr mixing with sign material, analyze according to method shown in AOAC standard.
(3) blood biochemical is learned index
For blood sampling, choose arbitrarily 6 for each group, when starting and while finishing, from jugular vein, take 2mL to analyze, utilize automatic hematology analyzer research leucocyte, red blood cell and IgG and lymphocyte.In addition, serum biochemistry is learned and is checked, when on-test and end, with heparin tube, takes 5mL, and 4 ℃, centrifugal 30 minutes of 3000rpm, is used for serum to analyze.Total protein in serum and albumin, adopt Biuret method and BCG, utilizes automatic biochemical Epidemiological Analysis instrument to analyze.
(4) statistical analysis (with experimental example 1)
Two results and discussion
1 production performance
When feed interpolation is of the present invention, as shown in table 2 on the impact from newborn weaned piglets.Body weight when finishing from breast, PC and HE group are significantly higher than CON, HE1 and HE2 group (P < 0.05).For adding weight, PC group is significantly higher than CON, HE1 and HE2 group, and HE group, compared with CON, HE1 and HE2 group, has statistical significance.
In table 2 feed, add different additive to the impact from newborn piglet
2 nutrient digestion rates
When feed adds pre-anti-diarrhea Chinese medicine, to from newborn piglet nutrient digestion rate dry, nitrogen, energy digestibility aspect, each group without significant difference (P > 0.05).PC and HE group improve 3% left and right.
3 blood parameters
When feed adds pre-anti-diarrhea Chinese medicine, to the leucocyte from newborn piglet blood biochemical indicator, red blood cell, IgG and lymphocyte aspect, each group without significant difference (P > 0.05).
Therefore, when the present invention is used for from newborn piglet, can increase its daily gain, reduce feed intake, obviously improve feed efficiency, improve nutrient digestion rate, the generation of the diseases such as prevention and minimizing diarrhoea, the effects such as the anti-inflammation antidiarrheal having had.
Experimental example 3: the impact of the energy for growth on the pig that grows from newborn piglet one
One material and method
1, experimental animal and grouping
Take 3 yuan of cenospecies ((Landrace xYorkshire) xDuroc) from 200 of newborn piglets, in order to supply examination animal, during on-test, equal body weight is 7kg, on general farm, carries out the test in 10 weeks (5 weeks 5 weeks+growth periods of piglet phase).
Processed group: (1), normal group (CON, basal diet), (2), Chinese medicine control group (HE, basal diet+0.5% Chinese herbal feed additive (CN101066313B, 2011.04.20)), (3), test group HE1 (basal diet+0.2% embodiment of the present invention 3 feed addictives), (4), test group HE2 (basal diet+0.2% embodiment of the present invention 1 feed addictive), (5), every group of test group HE3 (basal diet+0.2% embodiment of the present invention 2 feed addictives) repeat 2 times, 20 of every repetitions.
2, testing index and method
(1) productivity
Body weight and feed intake when on-test, 5 weeks and while finishing (10 weeks) measure respectively, calculate its adding weight, day feed intake and feed efficiency.
(2) Incidence of Diarrhea
About Incidence of Diarrhea, from newborn piglet from 1 stage feed, (from newborn 1 stage of piglet feed) transfers 1-6 day 2 stage feeds (from newborn 2 stage of piglet feed) to, and start after 5 weeks from No. 3 feeds transfer growth pig feed to after 1-6 day, for all individualities, carrying out the rear record of hepatic portal massage, is the number of individuals of diarrhoea through observe and decide.
3, statistical disposition
All data by the general linear model of SAS (1996), are carried out duncan's new multiple range method processing, checking mean value otherness.
Two results and discussion
1, production performance
In pig starter feed, add the present invention as shown in table 3 on the impact of production capacity.For the 5th week body weight, adding weight and feed efficiency, HE1, HE2, HE3 group are conspicuousness rising (P < 0.05) compared with control group and HE group, day feed intake aspect, HE3 group and control group and HE group have remarkable rising (P < 0.05).(10 kitchen) body weight during off-test, adding weight and feed intake aspect, HE1, HE2, HE3 group remarkable rising compared with control group and HE group (P < 0.05), at whole duration of test, HE1, HE2, HE3 compared with control group and HE, daily gain raise (P < 0.05).
In table 3 pig starter feed, add the impact of the present invention on energy for growth
2, Scours index
In pig starter feed, add that the piglet number of diarrhoea occurs when of the present invention is as shown in table 4, after breast, raise in giving a birth 4-5 day, give No. 1 feed (from 1 stage of sucking pig feed), after movement, give 2 stage feeds, No. 2 feeds (from 2 stage of sucking pig feed) gave after 1 day, there is 4-7 symptom of diarrhea in each processed group, but HE2 group and HE3 group do not observe the piglet of suffering from diarrhoea in test the 3rd day, H group and HE1 group stop in test diarrhoea on the 4th, control group (CON) stops in test diarrhoea on the 6th, in test, within the 3rd week, give No. 3 feeds (from 3 stage of sucking pig feed), within the 4th week, start to give No. 3 feeds 50% and the pig feed (piglet feed) 50% of growing.There is 2-3 symptom of diarrhea in control group and HE group, but after spending 1-2 day, symptom is stable after giving feed, and HE1, HE2, HE3 group also do not occur diarrhoea after changing feed.
The impact of table 4 the present invention on grice diarrhoea after breast
Table 5 the present invention is on changing the impact of suffering from diarrhoea after growth pig feed
Experimental example 4: on the impact research of growing-finishing pigs ability
1, experimental animal and experimental design
Take 3 yuan of cenospecies (Landrace xYorkshire xDuroc)) from 144 of newborn piglets, be confession examination animal, during on-test, equal body weight is 50.09kg, carries out the feeding experiment of 10 weeks by a definite date in farm.
Processed group is (1), CON (daily ration), (2), A (daily ration+embodiment of the present invention 10.1%), (3), B (daily ration+embodiment of the present invention 20.1%), totally 3 groups, every group is repeated 12 times, 4 of every repetitions.
2, testing index and method
When on-test, body weight and feed intake are measured respectively in (5 weeks), end (10 weeks), calculate adding weight, day feed intake and feed efficiency.
3, statistical disposition
All data are utilized the general linear model of SAS (1996), by duncan's new multiple range method processing, verify each mean value otherness.
Two results and discussion
1, production performance
During to fattening pannage Chinese herbal medicine of the present invention, as shown in table 6 on productive impact, 0-5 week and whole duration of test, about day increment, interpolation group (A and B) remarkable rising compared with control group (CON) (P < 0.05), the day increment aspect in 5-10 week, A group is than the remarkable rising of control group (CON) (P < 0.05).Day feed intake and the feed efficiency aspect of 0-5 week, 5-10 week and whole duration of test, each processed group is without significant difference.
In table 6 feed, add the present invention to fattening the impact of production performance
Add the present invention, can increase daily gain and the daily ingestion amount of fattening pig, improve to a certain extent feed efficiency.From result of the test feed efficiency do not significantly improve and daily gain and daily ingestion amount increase all obvious conclusion show, the mechanism that the present invention brings into play its growth promoting function may be prevention organism disease, improves immunity of organisms, increase the palatability of feed etc.
Above embodiment shows and has described basic principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; rather than limit the scope of the invention by any way; without departing from the scope of the invention; the present invention also has various changes and modifications, and these changes and improvements all fall in claimed scope.
Claims (9)
1. one kind has the natural feed addictive of antidiarrheal antibacterial and anti-inflammation functions, by main ingredient and the optional auxiliary material existing, formed, it is characterized in that, described main ingredient is by geranium wilfordii, cordate houttuynia, garden burnet, Chinese gall, radix berberidis or golden cypress, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane and cortex acanthopanacis composition, by weight, 5～40 parts of geranium wilfordiis, 5～40 parts of cordate houttuynias, 2～15 parts of garden burnets, 2～35 parts, Chinese gall, 2～20 parts of radix berberidis or golden cypresses, 1～20 part, Radix Glycyrrhizae, 0.5～10 part of the root of large-flowered skullcap, 1～8 part of polygonum perfoliatum, 5～10 parts, official hats and canopies rattan, 2～30 parts of purslanes, 2～18 parts of cortex acanthopanacis.
2. feed addictive according to claim 1, main ingredient is wherein: 10 parts of geranium wilfordiis, 12 parts of cordate houttuynias, 14 parts of garden burnets, 12 parts, Chinese gall, 12 parts of golden cypresses, 4 parts, Radix Glycyrrhizae, 4 parts of the roots of large-flowered skullcap, 6 parts of polygonum perfoliatums, 6 parts, official hats and canopies rattan, 12 parts of purslanes, 8 parts of cortex acanthopanacis.
3. feed addictive according to claim 1 and 2,0～52 part of auxiliary material wherein, auxiliary material is one or more in wheat bran, rice bran, dextrin, starch, inferior powder.
4. the feed addictive described in claim 1-3 any one has the purposes in the poultry and livestock feed of antidiarrheal, antibacterial or antiinflammation in preparation.
5. purposes according to claim 4, described poultry and livestock feed is for preventing or treat the disease of domestic birds and animals respiratory tract or enteron aisle.
6. purposes according to claim 5, wherein said disease is pneumonia or dysentery.
7. the preparation method of the natural feed addictive described in claim 1-3 any one, is characterized in that:
A, geranium wilfordii, garden burnet, Chinese gall, barberry, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane, golden cypress and cortex acanthopanacis, with solvent extraction, collect extract after difference or mixing, and removal solvent obtains extract;
B, cordate houttuynia, the flash extraction of water, collects extract, removes solvent and obtains extract;
C, step a and b be extract obtained is dried to dry cream, pulverizes, and optionally adds auxiliary material, mixes and get final product.
8. the preparation method of the natural feed addictive described in claim 1-3 any one, is characterized in that:
A, cordate houttuynia are extracted volatile oil, and volatile oil is made to cyclodextrin inclusion compound, and the dregs of a decoction save backup;
B, geranium wilfordii, garden burnet, Chinese gall, barberry, Radix Glycyrrhizae, the root of large-flowered skullcap, polygonum perfoliatum, official hats and canopies rattan, purslane, golden cypress and cortex acanthopanacis, together with the dregs of a decoction that obtain in step a, after difference or mixing, with solvent extraction, collect extract, removal solvent obtains extract;
C, step b be extract obtained is dried to dry cream, pulverizes, and optionally adds auxiliary material, adds the cyclodextrin inclusion compound in step a to mix and get final product.
9. the preparation method of the natural feed addictive described in claim 1-3 any one, is characterized in that, described main ingredient medicinal material is pulverized separately or after mixing, and optionally adds auxiliary material, after mixing and get final product.
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| CN104970197A (en) * | 2015-06-29 | 2015-10-14 | 何以安 | Feed additive for preventing infectious pleuropneumonia of goat |
| CN105010823A (en) * | 2015-06-29 | 2015-11-04 | 何以安 | Feed additive for preventing and treating ovine progressive pneumonia |
| CN105362361A (en) * | 2015-11-20 | 2016-03-02 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | Traditional Chinese medicine capable of treating dysentery |
| CN105639120A (en) * | 2015-12-29 | 2016-06-08 | 湖南晶天科技实业有限公司 | Cyclodextrin inclusion compound containing antibiotic components, a compounding method thereof and feed additive |
| CN106074785A (en) * | 2016-07-31 | 2016-11-09 | 甘肃农业大学 | A kind of Chinese medicinal formulae treating cattle diarrhea due to damp-heat and preparation method thereof |
| CN107961284B (en) * | 2017-12-29 | 2021-01-26 | 四川农业大学 | Oral preparation for preventing and treating piglet diarrhea and preparation method thereof |
| CN112998127A (en) * | 2021-04-26 | 2021-06-22 | 长沙博海生物科技有限公司 | Feed additive for improving content of nervonic acid and arginine in animal body |
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