CN112998127A - Feed additive for improving content of nervonic acid and arginine in animal body - Google Patents
Feed additive for improving content of nervonic acid and arginine in animal body Download PDFInfo
- Publication number
- CN112998127A CN112998127A CN202110453084.4A CN202110453084A CN112998127A CN 112998127 A CN112998127 A CN 112998127A CN 202110453084 A CN202110453084 A CN 202110453084A CN 112998127 A CN112998127 A CN 112998127A
- Authority
- CN
- China
- Prior art keywords
- parts
- feed additive
- vitamin
- arginine
- content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003674 animal food additive Substances 0.000 title claims abstract description 41
- GWHCXVQVJPWHRF-KTKRTIGZSA-N (15Z)-tetracosenoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-KTKRTIGZSA-N 0.000 title claims abstract description 23
- XJXROGWVRIJYMO-SJDLZYGOSA-N Nervonic acid Natural products O=C(O)[C@@H](/C=C/CCCCCCCC)CCCCCCCCCCCC XJXROGWVRIJYMO-SJDLZYGOSA-N 0.000 title claims abstract description 23
- GWHCXVQVJPWHRF-UHFFFAOYSA-N cis-tetracosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCCCCCC(O)=O GWHCXVQVJPWHRF-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 239000004475 Arginine Substances 0.000 title claims abstract description 21
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 241001465754 Metazoa Species 0.000 title claims abstract description 16
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 title abstract description 15
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940088594 vitamin Drugs 0.000 claims abstract description 15
- 229930003231 vitamin Natural products 0.000 claims abstract description 15
- 235000013343 vitamin Nutrition 0.000 claims abstract description 15
- 239000011782 vitamin Substances 0.000 claims abstract description 15
- -1 arazyme Chemical compound 0.000 claims abstract description 14
- 239000005844 Thymol Substances 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 11
- 229960000790 thymol Drugs 0.000 claims abstract description 11
- 241001166194 Geranium wilfordii Species 0.000 claims abstract description 9
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 9
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 9
- 150000001413 amino acids Chemical class 0.000 claims abstract description 9
- 235000006533 astragalus Nutrition 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- 235000011477 liquorice Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 244000144972 livestock Species 0.000 claims abstract description 7
- 244000144977 poultry Species 0.000 claims abstract description 7
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims abstract description 7
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims abstract description 7
- 241001061264 Astragalus Species 0.000 claims abstract description 6
- 210000004233 talus Anatomy 0.000 claims abstract description 6
- 239000011248 coating agent Substances 0.000 claims description 15
- 238000000576 coating method Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 241000972672 Phellodendron Species 0.000 claims description 7
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 4
- 239000009636 Huang Qi Substances 0.000 claims description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 4
- 229930003451 Vitamin B1 Natural products 0.000 claims description 4
- 229930003779 Vitamin B12 Natural products 0.000 claims description 4
- 229930003471 Vitamin B2 Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 4
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 4
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 4
- 229960002477 riboflavin Drugs 0.000 claims description 4
- 229960003495 thiamine Drugs 0.000 claims description 4
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 4
- 235000010374 vitamin B1 Nutrition 0.000 claims description 4
- 239000011691 vitamin B1 Substances 0.000 claims description 4
- 235000019163 vitamin B12 Nutrition 0.000 claims description 4
- 239000011715 vitamin B12 Substances 0.000 claims description 4
- 235000019164 vitamin B2 Nutrition 0.000 claims description 4
- 239000011716 vitamin B2 Substances 0.000 claims description 4
- 235000019158 vitamin B6 Nutrition 0.000 claims description 4
- 239000011726 vitamin B6 Substances 0.000 claims description 4
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 4
- 235000005282 vitamin D3 Nutrition 0.000 claims description 4
- 239000011647 vitamin D3 Substances 0.000 claims description 4
- 229940011671 vitamin b6 Drugs 0.000 claims description 4
- 229940021056 vitamin d3 Drugs 0.000 claims description 4
- 241000045403 Astragalus propinquus Species 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 241000972673 Phellodendron amurense Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 235000016709 nutrition Nutrition 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 3
- 235000013372 meat Nutrition 0.000 abstract description 3
- 241000218691 Cupressaceae Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 14
- 239000008187 granular material Substances 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 5
- 235000015277 pork Nutrition 0.000 description 5
- 241000282887 Suidae Species 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000003792 cranial nerve Anatomy 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010047141 Vasodilatation Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a feed additive for improving the content of nervonic acid and arginine in an animal body, and belongs to the technical field of feed additives. The feed additive comprises the following raw materials: geranium wilfordii, gallnut, golden cypress, xylo-oligosaccharide, arazyme, liquorice, thymol, compound vitamin, astragalus and cortex acanthopanacis. The feed additive has reasonable raw material compatibility, can improve the content of unsaturated fatty acid and amino acid in animal bodies, has particularly obvious effect on improving the content of nervonic acid and arginine, and can be widely applied to the feeding of livestock and poultry; the meat fat structure of the livestock and poultry fed by the feed containing the additive can meet the nutritional requirements of human health.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a feed additive for improving the content of nervonic acid and arginine in an animal body.
Background
Nervonic Acid (NA) of the general formula C24H46O2Is a unit unsaturated fatty acid, and domestic and foreign researches show that the nervonic acid is the nucleus of brain nerve cells and nerve tissuesThe heart natural component is a specific substance which is found in the world so far and can promote the repair and regeneration of damaged nerve tissues, is an essential 'high-grade nutrient' for the growth, regeneration and maintenance of nerve cells, particularly brain cells, optic nerve cells and peripheral nerve cells, has great effects on improving the activity degree of cranial nerves and preventing cranial nerve aging, and is called 'gold life'.
Nervonic acid can only be synthesized in trace amount in human body, and can not meet the requirement of human body, and the nervonic acid in the body can be lost when the brain and eyes are excessively used, so that the 'malnutrition' of nerve cells is caused, the cells are not aged and senilised, and therefore the nervonic acid must be supplemented in time to activate the cells and recover the function.
Arginine is the basic composition of various proteins and is relatively extensive, arginine can be converted into nitric oxide in a human body, and indirectly causes vasodilatation, regulates the immunologic function, reduces cell inflammation and prevents infection, and clinical researches find that arginine is helpful for preventing cardiovascular diseases, diabetes, hypertension and the like and has no side effect caused by western medicines; it also has effects of promoting spermatogenesis and improving sperm kinetic energy. The human body properly supplements arginine, which has positive effects on improving body functions and improving memory capacity.
The food intake mode is one of the main modes for supplementing fatty acid and amino acid for human body, improves the content of nervonic acid and arginine in animal body, and can ensure that the human body can obtain enough nervonic acid and arginine for supplementing through daily ingested meat products. Therefore, how to significantly increase the content of nervonic acid and arginine in animals is a technical problem to be solved urgently at present.
Disclosure of Invention
The invention aims to provide a feed additive for improving the content of nervonic acid and arginine in an animal body, so as to solve the problems in the prior art, obviously improve the content of nervonic acid and arginine in the animal body, and meet the nutritional requirement of human health by a meat fat structure.
In order to achieve the purpose, the invention provides the following scheme:
one of the technical schemes of the invention is to provide a feed additive, which comprises the following raw materials in parts by weight:
13-16 parts of geranium wilfordii, 9-12 parts of gallnut, 9.5-9.8 parts of phellodendron, 5-6 parts of xylo-oligosaccharide, 23-25 parts of arazyme, 8-12 parts of liquorice, 0.5-0.6 part of thymol, 0.01-0.015 part of vitamin complex, 8-12 parts of astragalus mongholicus and 14-16 parts of cortex acanthopanacis;
the compound vitamin is vitamin B1, vitamin B2, vitamin B12, vitamin B6 and vitamin D3 in a mass ratio of 0.003-0.0012: 0.005-0.0015: 0.006-0.0014: 0.001-0.0018: 0.0006 to 0.0013.
Further, the raw materials comprise the following components in parts by weight:
15 parts of geranium wilfordii, 10 parts of gallnut, 9.5 parts of phellodendron, 5 parts of xylo-oligosaccharide, 25 parts of arazyme, 10 parts of liquorice, 0.5 part of thymol, 0.01 part of vitamin complex, 10 parts of astragalus and 15 parts of cortex acanthopanacis.
The second technical scheme of the invention provides a preparation method of the feed additive, which comprises the following steps:
pulverizing herba Erodii seu Geranii, Galla chinensis, cortex Phellodendri, Glycyrrhrizae radix, radix astragali and cortex Acanthopanacis, and mixing with xylooligosaccharide, arazyme, thymol and compound vitamin to obtain the feed additive.
Further, the mesh number of the ground geranium wilfordii, gallnut, phellodendron, liquorice, astragalus and cortex acanthopanacis is more than 200 meshes.
Further, the mixing process also includes the steps of granulating and coating.
Furthermore, the temperature during granulation is 40-55 deg.C, and the water content of the granulated granule is 2-2.7%.
Further, the temperature during coating is 55-60 ℃; the coating material is hydroxymethyl cellulose; the water content after coating is less than or equal to 2.8 percent.
The third technical scheme of the invention is to provide the application of the feed additive in improving unsaturated fatty acid and/or amino acid feed in animal bodies.
Further, the unsaturated fatty acid is a nervonic acid, and the amino acid is arginine.
Further, the animal is livestock or poultry.
The invention discloses the following technical effects:
the feed additive disclosed by the invention is reasonable in raw material compatibility, can improve the content of unsaturated fatty acid and amino acid in animal bodies, is especially obvious in effect of improving the content of nervonic acid and arginine, and the fleshy fat structure of livestock and poultry fed by the feed containing the feed additive disclosed by the invention can meet the nutritional requirements on human health.
The feed additive can be widely applied to the feeding of livestock and poultry, has wide application range and good effect of improving the content of nervonic acid and arginine in the bodies of the livestock and the poultry.
Detailed Description
Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference herein for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The description and examples are intended to be illustrative only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.
The "parts" in the present invention are in parts by weight unless otherwise specified.
Example 1
A feed additive for improving the content of nervonic acid and arginine in animal bodies comprises the following raw materials in parts by weight:
13 parts of geranium wilfordii, 12 parts of gallnut, 9.8 parts of phellodendron, 6 parts of xylo-oligosaccharide, 23 parts of arazyme, 8 parts of liquorice, 0.6 part of thymol, 0.015 part of vitamin complex, 8 parts of astragalus and 14 parts of cortex acanthopanacis;
wherein the compound vitamin is vitamin B1, vitamin B2, vitamin B12, vitamin B6 and vitamin D3 in a mass ratio of 0.003: 0.005: 0.006: 0.0018: 0.0013.
The preparation method comprises the following steps:
(1) micronizing herba Erodii seu Geranii, Galla chinensis, cortex Phellodendri, Glycyrrhrizae radix, radix astragali and cortex Acanthopanacis of formula amount to 200 mesh by superfine pulverization technique to obtain superfine powder mixture A;
(2) mixing xylo-oligosaccharide, arazyme, thymol and compound vitamin according to the formula amount to obtain a mixture B;
(3) uniformly mixing the superfine powder mixture A and the mixture B, putting the mixture into a one-step granulator, and granulating at 55 ℃, wherein the water content of the granulated granules is 2.7%;
(4) preparing 4 wt% aqueous solution by taking hydroxymethyl cellulose as a coating material, coating the granules in a one-step granulator at the flow rate of 50L/h and the temperature of 80 ℃ and the amount of the coating material of 2.5% of the weight of the granules, and drying after coating to ensure that the water content is less than or equal to 2.6% to obtain the feed additive (KY 01-091).
Example 2
A feed additive for improving the content of nervonic acid and arginine in animal bodies comprises the following raw materials in parts by weight:
15 parts of geranium wilfordii, 10 parts of gallnut, 9.5 parts of phellodendron, 5 parts of xylo-oligosaccharide, 25 parts of arazyme, 10 parts of liquorice, 0.5 part of thymol, 0.01 part of vitamin complex, 10 parts of astragalus and 15 parts of cortex acanthopanacis;
wherein the compound vitamin is vitamin B1, vitamin B2, vitamin B12, vitamin B6 and vitamin D3 in a mass ratio of 0.0012: 0.0015: 0.0014: 0.001: 0.0006 composition of the mixture.
The preparation method comprises the following steps:
(1) micronizing herba Erodii seu Geranii, Galla chinensis, cortex Phellodendri, Glycyrrhrizae radix, radix astragali and cortex Acanthopanacis of formula amount to 300 mesh by superfine pulverization technique to obtain superfine powder mixture A;
(2) mixing xylo-oligosaccharide, arazyme, thymol and compound vitamin according to the formula amount to obtain a mixture B;
(3) uniformly mixing the superfine powder mixture A and the mixture B, putting the mixture into a one-step granulator, and granulating at 45 ℃, wherein the water content of the granulated granules is 2%;
(4) preparing 5.5 wt% aqueous solution with hydroxymethyl cellulose as coating material, coating the granules in a one-step granulator at a flow rate of 65L/h and a temperature of 75 deg.C, wherein the coating material is 3% of the weight of the granules, and drying to water content less than or equal to 2.8% to obtain the feed additive (W03-001).
Effect verification experiment:
healthy adult domestic pigs of the same age of the month and fed under the same feeding condition are divided into 5 groups, and each group is fed with 30 pigs on average, wherein the feed feeding condition of each group is as follows:
experimental group 1: adding the feed additive (KY01-091) prepared in example 1 into basal pig feed according to the addition amount of 0.2%;
experimental group 2: the feed additive (W03-001) prepared in example 2 was added to basal pig feed at an addition level of 0.2%;
control group 1: adding commercially available feed additive (KY01-092) into basic pig feed at an addition amount of 0.2%;
control group 2: commercial feed additive (W03-003) was added to the basal pig feed at an amount of 0.2%.
Blank control group: feeding basal pig feed.
The above groups were fed under normal feeding conditions except for the difference in feed additives, and the feeding conditions were the same during the experiment, and the pigs were fed with free food and water. After the domestic pigs of each group are fed and slaughtered, fresh pork is taken for inspection, and the compositions of amino acid and fatty acid of the pork of each group are detected according to the detection standards GB 5009.124-2016 and GB 5009.168-2016.
The average values of the results of the tests of the respective groups are shown in Table 1.
TABLE 1
The results of index comparison of amino acids and fatty acids of the pork of the experimental group using the feed additives KY01-091 and W03-001 and the pork of the control group using the commercial feed additives KY01-092 and W03-003 are shown in Table 2.
TABLE 2
Note: the total A is the total value of the feed additives KY01-091 and W03-0012, and the total B is the total value of the commercial feed additives KY01-092 and W03-003.
As can be seen from the table, the feed additive provided by the invention can obviously improve the content of nervonic acid and arginine in pork, the effect of the feed additive can reach 1.4 times that of the existing feed additive, meanwhile, the content of other components is improved, and data results show that the structure of meat fat changes towards the healthy and nutritional requirements of human bodies.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.
Claims (10)
1. The feed additive is characterized in that the raw materials comprise the following components in parts by weight:
13-16 parts of geranium wilfordii, 9-12 parts of gallnut, 9.5-9.8 parts of phellodendron, 5-6 parts of xylo-oligosaccharide, 23-25 parts of arazyme, 8-12 parts of liquorice, 0.5-0.6 part of thymol, 0.01-0.015 part of vitamin complex, 8-12 parts of astragalus mongholicus and 14-16 parts of cortex acanthopanacis;
the compound vitamin is vitamin B1, vitamin B2, vitamin B12, vitamin B6 and vitamin D3 in a mass ratio of 0.003-0.0012: 0.005-0.0015: 0.006-0.0014: 0.001-0.0018: 0.0006 to 0.0013.
2. The feed additive according to claim 1, wherein the raw materials comprise the following components in parts by weight:
15 parts of geranium wilfordii, 10 parts of gallnut, 9.5 parts of phellodendron, 5 parts of xylo-oligosaccharide, 25 parts of arazyme, 10 parts of liquorice, 0.5 part of thymol, 0.01 part of vitamin complex, 10 parts of astragalus and 15 parts of cortex acanthopanacis.
3. A process for the preparation of a feed additive according to any one of claims 1-2, comprising the steps of:
pulverizing herba Erodii seu Geranii, Galla chinensis, cortex Phellodendri, Glycyrrhrizae radix, radix astragali and cortex Acanthopanacis, and mixing with xylooligosaccharide, arazyme, thymol and compound vitamin to obtain the feed additive.
4. The method for preparing a feed additive according to claim 3, wherein the mesh number of the pulverized geranium wilfordii, gallnut, phellodendron amurense, liquorice, astragalus mongholicus and cortex acanthopanacis is more than 200 meshes.
5. The method of claim 3, further comprising the steps of granulating and coating after mixing.
6. The process for preparing a feed additive according to claim 5, wherein the temperature during the granulation is 40-55 ℃, and the moisture content of the granulated feed additive is 2-2.7%.
7. The method for preparing feed additive according to claim 5, wherein the temperature at the time of coating is 55-60 ℃; the coating material is hydroxymethyl cellulose; the water content after coating is less than or equal to 2.8 percent.
8. Use of a feed additive according to any one of claims 1-2 for increasing the unsaturated fatty acid and/or amino acid content of an animal.
9. The use according to claim 8, wherein the unsaturated fatty acid is a nervonic acid and the amino acid is arginine.
10. Use according to claim 8, wherein the animal is livestock or poultry.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110453084.4A CN112998127B (en) | 2021-04-26 | 2021-04-26 | Feed additive for improving content of nervonic acid and arginine in animal body |
| KR1020227012921A KR20220148796A (en) | 2021-04-26 | 2021-08-02 | Feed additive that increases the content of nervonic acid and arginine in the animal body |
| PCT/CN2021/110093 WO2022227323A1 (en) | 2021-04-26 | 2021-08-02 | Feed additive for increasing content of nervonic acid and arginine in animal bodies |
| DE112021000116.7T DE112021000116T5 (en) | 2021-04-26 | 2021-08-02 | FEED ADDITIVE TO IMPROVE LEVELS OF NERVOUS ACID AND ARGININE IN ANIMALS |
| JP2022519995A JP7312319B2 (en) | 2021-04-26 | 2021-08-02 | A feed additive that increases the content of nervonic acid and arginine in animals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110453084.4A CN112998127B (en) | 2021-04-26 | 2021-04-26 | Feed additive for improving content of nervonic acid and arginine in animal body |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112998127A true CN112998127A (en) | 2021-06-22 |
| CN112998127B CN112998127B (en) | 2024-06-25 |
Family
ID=76380396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110453084.4A Active CN112998127B (en) | 2021-04-26 | 2021-04-26 | Feed additive for improving content of nervonic acid and arginine in animal body |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP7312319B2 (en) |
| KR (1) | KR20220148796A (en) |
| CN (1) | CN112998127B (en) |
| DE (1) | DE112021000116T5 (en) |
| WO (1) | WO2022227323A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022227323A1 (en) * | 2021-04-26 | 2022-11-03 | 长沙博海生物科技有限公司 | Feed additive for increasing content of nervonic acid and arginine in animal bodies |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919203A (en) * | 2005-06-23 | 2007-02-28 | 维京仲华（上海）生物医药科技有限公司 | Method for enhancing nutrient absorption with astragalosides |
| US20100099633A1 (en) * | 2005-06-23 | 2010-04-22 | Nuliv Holding Inc. | Method for enhancing nutrient absorption with astragalosides |
| CN102894229A (en) * | 2012-10-24 | 2013-01-30 | 刘向前 | Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof |
| CN103689279A (en) * | 2013-12-12 | 2014-04-02 | 济南新起点医药科技有限公司 | Feed additive for laying hen |
| CN109380644A (en) * | 2018-09-26 | 2019-02-26 | 山西大禹生物工程股份有限公司 | Farm's specific complex microbial deodorant and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105981921A (en) * | 2015-05-23 | 2016-10-05 | 韩敬阳 | Chinese herbal medicinal compound premix for laying hens and manufacturing method thereof |
| CN106173294A (en) * | 2016-07-13 | 2016-12-07 | 四川贡牛生物饲料有限公司 | Ruminant stomach animal is fattened growth-promoting feedstuff additive |
| CN108065034A (en) * | 2017-12-23 | 2018-05-25 | 湖南盛东生物科技有限公司 | Cad pig is promoted to take off stiff Chinese herbal feed additive and preparation and application |
| CN109043146A (en) * | 2018-10-12 | 2018-12-21 | 日照普惠动物营养科技有限公司 | A kind of feed addictive for milk cattle beneficiated burden material complemental feed |
| CN112998127B (en) * | 2021-04-26 | 2024-06-25 | 长沙博海生物科技有限公司 | Feed additive for improving content of nervonic acid and arginine in animal body |
-
2021
- 2021-04-26 CN CN202110453084.4A patent/CN112998127B/en active Active
- 2021-08-02 JP JP2022519995A patent/JP7312319B2/en active Active
- 2021-08-02 WO PCT/CN2021/110093 patent/WO2022227323A1/en active Application Filing
- 2021-08-02 DE DE112021000116.7T patent/DE112021000116T5/en active Pending
- 2021-08-02 KR KR1020227012921A patent/KR20220148796A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919203A (en) * | 2005-06-23 | 2007-02-28 | 维京仲华（上海）生物医药科技有限公司 | Method for enhancing nutrient absorption with astragalosides |
| US20100099633A1 (en) * | 2005-06-23 | 2010-04-22 | Nuliv Holding Inc. | Method for enhancing nutrient absorption with astragalosides |
| CN102894229A (en) * | 2012-10-24 | 2013-01-30 | 刘向前 | Natural feed additive with functions of relieving diarrhea, resisting bacteria and eliminating inflammation and preparation method thereof |
| CN103689279A (en) * | 2013-12-12 | 2014-04-02 | 济南新起点医药科技有限公司 | Feed additive for laying hen |
| CN109380644A (en) * | 2018-09-26 | 2019-02-26 | 山西大禹生物工程股份有限公司 | Farm's specific complex microbial deodorant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 于康: "吃的误区", vol. 1, 31 January 2018, 科学技术文献出版社, pages: 242 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022227323A1 (en) * | 2021-04-26 | 2022-11-03 | 长沙博海生物科技有限公司 | Feed additive for increasing content of nervonic acid and arginine in animal bodies |
Also Published As
| Publication number | Publication date |
|---|---|
| DE112021000116T5 (en) | 2022-12-29 |
| WO2022227323A1 (en) | 2022-11-03 |
| JP2023526702A (en) | 2023-06-23 |
| JP7312319B2 (en) | 2023-07-20 |
| CN112998127B (en) | 2024-06-25 |
| KR20220148796A (en) | 2022-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102100318B (en) | Chicken feed | |
| CN103892053B (en) | Pig growth promotion type green feed additive capable of replacing antibiotics | |
| CN103858824A (en) | Method for raising raw material pigs of air-dried fermented pork product | |
| CN105995048A (en) | Feed for improving muscle quality of carps and preparation method of feed | |
| CN102090543A (en) | Nettle pig feed | |
| CN112998127B (en) | Feed additive for improving content of nervonic acid and arginine in animal body | |
| CN109170328B (en) | Compound feed for cage-rearing laying ducks and preparation method thereof | |
| CN115067436B (en) | Preparation method of special feed additive for breeding fattening meat ducks | |
| CN103535548A (en) | Special compound feed for capons and preparation method thereof | |
| CN102987066A (en) | Preparation method of modified peanut straw pig feed and prepared pig feed | |
| CN102273559A (en) | Method for preparing feed of Tadorna ferruginea | |
| CN115024400A (en) | Livestock feed added with tea powder, preparation method and application thereof | |
| CN106306346B (en) | Method for raising live pigs without using feed antibiotics | |
| CN107183385B (en) | Feed additive for improving production performance of lactating sows and preparation method and application thereof | |
| CN111938033A (en) | Compound feed for overwintering of Rana temporaria and application thereof | |
| CN110574842A (en) | Mixed pig feed additive containing scutellaria baicalensis and lonicera confusa and preparation method thereof | |
| CN111700158A (en) | Composition with garlic residue as carrier and application thereof | |
| CN109511801A (en) | A kind of resisting stress syndrome feed additive and child care early-stage fodder | |
| CN109832476A (en) | A kind of 45-60 age in days big-broiler feedstuff formula | |
| CN115336675B (en) | Multifunctional duck feed additive and preparation method and application thereof | |
| CN110742178A (en) | Black-bone sheep feed capable of reducing feed cost and improving disease resistance and preparation method thereof | |
| CN106689771A (en) | Rabbit feed and preparation method thereof | |
| CN104996811A (en) | Composite chicken feed suitable for being fed in summer | |
| CN104543571A (en) | Feed capable of improving intestinal functions of pigs and preparation method of feed | |
| CN110973390A (en) | Feed composition for improving activity of aged pets |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |