CN1322884C - Purple perilla capsule and process for preparing the same - Google Patents

Abstract

The present invention relates to a purple common perilla capsule and a preparation method thereof, which provides a pure Chinese medicine for treating chronic bronchitis and the preparation method thereof. The Chinese medicinal preparation is prepared from more than ten Chinese herbal medicines such as purple common perilla, white nut, cassia bark, etc. The preparation method of the purple common perilla capsule is divided into four steps: three medicinal materials are made into powder, seven medicinal materials are decocted to obtain a thick paste, and the powder and the thick paste are mixed to make granules, and the granules are filled into capsules. The purple common perilla capsule has a scientific and novel formula, reasonable synergy, complementary medicine effect, simple production process, low cost and convenience for oral taking. The purple common perilla capsule can cure chronic bronchitis, and has obvious therapeutic effect on the symptoms of asthma, tussis, profuse sputum, oppression in chest, palpitation, edema, intolerance of cold, etc. which are caused by pneumonectasis, cor pulmonale, pneumonitis, etc.

Description

Treatment chronic bronchitis capsule and preparation technology thereof

Affiliated technical field

The present invention treats the chronic bronchitis capsule and preparation technology belongs to medicine and the preparation technology thereof who treats respiratory system disease, relates in particular to medicine and preparation technology thereof with Chinese prescription treatment chronic bronchitis.

Background technology

Chronic bronchitis is the frequently-occurring disease of serious harm people ' s health, commonly encountered diseases, clinically with cough with asthma, cough up phlegm and be main disease, or with panting, annual outbreak continues 3 months at least, and it is continuous more than 2 years, the Chinese medical discrimination standard card is divided into heat-phlegm, cold-phlegm, dyspnea of heat type, dyspnea due to cold four classes, assertive evidence is divided into insufficiency of lung-QI, deficiency of spleen-YANG, insufficiency of kidney-YANG, deficiency in both YIN and YANG four classes, pathogenic factor mostly is viral infection, the stimulation of regulating the flow of vital energy, factors such as human allergy, primary disease mostly occurs above middle age, the course of disease is slow, majority is the onset of hiding, and in morbidity cold season, occurs cough and expectoration symptom from the beginning of how, particularly attach most importance to early morning, the expectorant mucus spume shape that is white in color, thickness is difficult for expectoration, is infecting or the postemphasis of catching cold, amount of expectoration increases, viscosity increases or is yellow purulence, and apoplexy due to phlegm can be with blood sometimes, patient's complicated with pulmonary infection, easy concurrent bronchopneumonia, the treatment chronic bronchitis mostly is chemical agent at present, and oxytetracycline is arranged, tetracycline, sulfamethoxyplridazine etc., side effect is bigger, vaccinotherapy and Chinese herbal treatment are also arranged, but how can not reach treating both the principal and secondary aspects of a disease, the treatment phase is longer, in ancient times on the basis of tradition name side's Suzi Jiangqi Tang and sanzi yangqin decoction, add and simplify sanction, drafted this preparation prescription.

Summary of the invention

The objective of the invention is: the pure compound Chinese medicinal preparation that scientific formulation is provided to chronic bronchitis patient, reach that circulation of qi promoting is relievingd asthma, the effect of preventing phlegm from forming and stopping coughing, kill virus, treating both the principal and secondary aspects of a disease, effective treatment chronic bronchitis, and diseases such as the asthma that emphysema, pulmonary heart disease, pneumonia and other reason are caused, cough, excessive phlegm, uncomfortable in chest, nervous, edema, fear of cold also have significant curative effect.

In order to realize the foregoing invention purpose, the technical solution adopted in the present invention is: treatment chronic bronchitis capsule is according to the main etiology and pathogenesis of chronic bronchitis, with circulation of qi promoting relieving asthma, preventing phlegm from forming and stopping coughing, kill virus be principle of treatment, the crude drug total amount is 650 grams in the prescription, is made up of Fructus Perillae 110 grams, Semen Ginkgo 70 grams, Cortex Cinnamomi 60 grams, the Rhizoma Pinelliae 60 grams, Semen Sinapis 60 grams, Semen Raphani 60 grams, Radix Angelicae Sinensis 60 grams, Semen Lepidii (Semen Descurainiae) 60 grams, Radix Platycodonis 60 grams, Radix Glycyrrhizae 50 grams.Treatment chronic bronchitis capsule manufacture method adopts three flavor medical material powder process, seven flavor medicine material decocting to thick ointment, puddle granulation, dress capsule four road technologies, get Fructus Perillae earlier, Cortex Cinnamomi, Semen Sinapis three flavor Chinese herbal medicine powders are broken into the fine powder medicine, get Semen Ginkgo again, the Rhizoma Pinelliae, Semen Raphani, Radix Angelicae Sinensis, Semen Lepidii (Semen Descurainiae), Radix Platycodonis, Radix Glycyrrhizae seven flavor Chinese herbal medicine add 10 times of water gagings and decoct for the first time, decocted 2 hours, filter, medicinal residues add 8 times of water gagings again and decoct for the second time, decocted 1 hour, and filtered collecting decoction, and to be evaporated to relative density be 1.30 (80 ℃) thick paste, thick paste and fine powder medicine are mixed thoroughly, and oven dry is ground into fine powder below 80 ℃, granulate, divide in No. 1 capsule of packing into to get patent medicine.Chinese medicine is thought, the basic pathogenesis of the syndrome of dyspnea is gas and contrary disorderly in lung, because of the lung being the dominator of QI, department breathes, close fur outward, interior is the five internal organs canopy, if the exopathogen invasion and attack, or violate on his the disease of ZANG-organs gas, all can make Lung Qi obstraction, lung qi distension, breathe unfavorable and for breathing heavily, breathing heavily has two kinds of diseases caused by exogenous pathogenic factor and internal injuries, and the branch of deficiency and excess is arranged, excess-dyspnea is at lung, dyspnea due to deficiency is when the lung kidney of duty, exopathogen, expectorant are turbid, the stagnation of liver-QI QI rising in reverse order, evilly stop up lung qi, the not apparent symptom of benefit falls in a surname, in capsule, Fructus Perillae has sending down the abnormal ascending QI, expectorant, the function of relievining asthma, and cures mainly expectorant and stops up QI rising in reverse order, cough and asthma; Semen Ginkgo has the astringing lung QI for relieving asthma function, and staphylococcus, streptococcus, diphtheria corynebacterium, multiple sick kind of bacillus pyocyaneus are had bacteriostasis, cures mainly the asthma phlegmatic cough; Cortex Cinnamomi have mend that fire is supporing yang, benefitting liver and lung gas, let the fire back to its origin, dispersing cold for relieving pain, go to defend in the ailment said due to cold or exposure function, contained cinnamic aldehyde has very strong bactericidal antiphlogistic effect, cures mainly insufficiency of kidney-YANG, the dyspnea with rapid and short breath of losing heart; The Rhizoma Pinelliae has drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, energy expectorant saliva, appetite promoting and the spleen strengthening function, cures mainly cough with copious phlegm, vomiting regurgitation, the full knot of diabetes with polydipsia as the prominent symptom abdomen septum pectorale expectorant heat, goes typhoid fever cold and heat laryngopharynx to swell and ache; Semen Sinapis has warming spleen and stomach for dispelling cold, the sharp key of eliminating phlegm, collateral dredging detumescence, warming middle-JIAO appetizing function, cures mainly gastrofrigid vomiting, trusted subordinate's cold type of pain, cough with copious phlegm, rheumatic arthralgia; Semen Raphani has dyspepsia and intestinal stasis relieving, lowering the adverse-rising QI to resolve phlegm, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the expansion that disappears, expectorant saliva, fall expectorant contrary, shout and breathe heavily function surely, cure mainly that stagnation of QI due to dyspepsia, gastral cavity abdominal distention expand, cough ant phlegm, QI rising in reverse order dyspnea with fullness of the chest; Radix Angelicae Sinensis has enriches blood, invigorates blood circulation, moisturizes the function that laxation, preventing or arresting vomiting are contrary, remove plug in the objective blood, cures mainly all cards of blood deficiency, tonifying five ZANG-organs, QI rising in reverse order and has to go to the toilet; Roripa Fu has eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, expels the heat-evil by evil function, cures mainly the swollen lung abscess of breathing heavily that sputum is stopped up the dyspnea and cough with excessive sputum of lung, heart failure; Radix Platycodonis has lung qi dispersing, eliminates the phlegm, sore-throat relieving, pus drainage functions, cures mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus; Radix Glycyrrhizae has QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription function, cures mainly cough and asthma, laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore.In prescription, the Semen Ginkgo astringing lung QI for relieving asthma eliminates the phlegm, the Folium Perillae lowering the adverse-rising QI and dispelling phlegm, be monarch drug altogether, Cortex Cinnamomi the kidney warming cold relieving, helping inspiration to relieve asthma, Semen Sinapis Albae warming the lung promoting the circulation of QI, soon every expectorant, the pinellia tuber for relieving cough resolving phlegm and relieving asthma, the three is combined into ministerial drug, to help Semen Ginkgo, the Folium Perillae the kidney warming is astringed the lung, lowering the adverse-rising QI to subdue asthma, the Semen Raphani dyspepsia and intestinal stasis relieving, circulation of qi promoting is eliminated the phlegm, Chinese Angelica blood replonishing is invigorated blood circulation, Semen Lepidii (Semen Descurainiae) gets final product inducing diuresis to remove edema, can relieving asthma three medicine circulation of qi promoting again, diuresis of blood circulation promoting, be adjuvant drug altogether, Radix Platycodonis relieving cough and asthma, the Radix Glycyrrhizae property of medicine of easing up, but QI invigorating again, be messenger drug altogether, playing circulation of qi promoting altogether relievings asthma, the preventing phlegm from forming and stopping coughing effect is effectively cured chronic bronchitis, and to emphysema, pulmonary heart disease, the asthma that pneumonia and other reason cause, cough, excessive phlegm, uncomfortable in chest, nervous, edema, symptoms such as fear of cold also have significant curative effect.The purple perilla capsule preparation method adopts powder process medicine and decocting to thick ointment to puddle granulation, dress capsule technology, and production technology is simple, and is with low cost, convenient oral.

Treatment chronic bronchitis capsule cures mainly relevant Pharmacodynamic test of active extract with function and has confirmed significant curative effect in preclinical study, and to recommend oral dose be 3 times on the one, each 3-4 grain.

The invention has the beneficial effects as follows: the scientific formulation novelty, the monarch compatibility is proper, production technology is simple, with low cost, convenient oral has complementary functions by many medicines, reach that circulation of qi promoting is relievingd asthma, the preventing phlegm from forming and stopping coughing effect, can effectively cure chronic bronchitis, and to emphysema, symptom such as the asthma that diseases such as pulmonary heart disease, pneumonia cause, cough, excessive phlegm, uncomfortable in chest, nervous, edema, fear of cold also has significant curative effect.

Specific embodiments:

1, treatment chronic bronchitis capsule formula is made up of ten flavor Chinese herbal medicine, wherein Fructus Perillae 110 gram, Semen Ginkgo 70 grams, Cortex Cinnamomi 60 grams, the Rhizoma Pinelliae 60 grams, Semen Sinapis 60 grams, Semen Raphani 60 grams, Radix Angelicae Sinensis 60 grams, Semen Lepidii (Semen Descurainiae) 60 grams, Radix Platycodonis 60 grams, Radix Glycyrrhizae 50 grams, Radix Glycyrrhizae gets that to process the Radix Glycyrrhizae decoction pieces standby before the preparation; Weighing was standby after all the other Chinese herbal medicine were got crude drug remove impurity well sifted respectively by existing prepared slices of Chinese crude drugs standard.

2, treatment chronic bronchitis capsules preparation technique:

1. get Fructus Perillae, Cortex Cinnamomi, Semen Sinapis three flavor medical materials mixing pulverizing, cross 80 mesh sieves and become the fine powder medicine standby.

2. getting Semen Ginkgo, the Rhizoma Pinelliae, Semen Raphani, Radix Angelicae Sinensis, Semen Lepidii (Semen Descurainiae), Radix Platycodonis, Radix Glycyrrhizae seven flavor medicine material adds 10 times of water gagings and decocted 2 hours, filter, medicinal residues add 8 times of water gagings again and decocted 1 hour, filter, collecting decoction, and to be evaporated to relative density be that 1.30 (60 ℃) thick paste is standby.

3. thick paste and fine powder medicine are mixed thoroughly, oven dry was pulverized 80 mesh sieves and was become fine powder below 80 ℃, added an amount of ethanol and made soft material, crossed 14 order nylon mesh and granulated, and was dried into the granule medicine below 80 ℃.

4. granule medicine branch 1000 No. 1 capsules of packing into are got patent medicine.

Claims (2)

1, a kind of treatment chronic bronchitis capsule, it is characterized in that: the crude drug total amount is 650 grams in the prescription, is made up of Fructus Perillae 110 grams, Semen Ginkgo 70 grams, Cortex Cinnamomi 60 grams, the Rhizoma Pinelliae 60 grams, Semen Sinapis 60 grams, Semen Raphani 60 grams, Radix Angelicae Sinensis 60 grams, Semen Lepidii (Semen Descurainiae) 60 grams, Radix Platycodonis 60 grams, Radix Glycyrrhizae 50 grams.

2, treat the chronic bronchitis capsules preparation technique according to claim 1, it is characterized in that: get Fructus Perillae earlier, Cortex Cinnamomi, Semen Sinapis three flavor Chinese herbal medicine powders are broken into the fine powder medicine, get Semen Ginkgo again, the Rhizoma Pinelliae, Semen Raphani, Radix Angelicae Sinensis, Semen Lepidii (Semen Descurainiae), Radix Platycodonis, Radix Glycyrrhizae seven flavor Chinese herbal medicine add 10 times of water gagings and decoct for the first time, decocted 2 hours, filter, medicinal residues add 8 times of water gagings again and decoct for the second time, decocted 1 hour, and filtered collecting decoction, and relative density is 1.30 thick pastes when being evaporated to 80 ℃, thick paste and fine powder medicine are mixed thoroughly, and oven dry is ground into fine powder below 80 ℃, granulate, divide in No. 1 capsule of packing into to get patent medicine.