CN105796978A - Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome (PRRS) as well as preparation method and application method - Google Patents
Traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome (PRRS) as well as preparation method and application method Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine prescription for treating porcine reproductive and respiratory syndrome (PRRS) as well as a preparation method and application method, belonging to the technical field of veterinary drugs. A composition of fructus forsythiae, garlic, dandelion, corn stigma, gypsum, lophatherum gracile, honeysuckle, scutellaria baicalensis, radix astragali, radix puerariae, radix paeoniae alba and folium isatidis is used for treating the PRRS; the effects of the medicines can generate a synergistic effect; the medicines in the prescription are harmonized and together realize the functions of clearing heat and removing toxin, resisting bacteria and diminishing inflammation and improving the immunity and disease resistance of the organism; and an obvious cure effect is realized on the piglets and adult pigs suffering from the PRRS. Experiments indicate that an obvious treatment effect is realized on the PRRS of the piglets and adult pigs taking the traditional Chinese medicine prescription provided by the invention, and the effective rate can reach 85% or above.
Description
Technical field
The invention belongs to veterinary medicament technical field, particularly relate to and a kind of treat the Chinese prescription of pig blue-ear disease, manufacture method and using method.
Background technology
Porcine reproductive and respiratory syndrome, it is also called reproductive and respiratory syndrome, it is that a kind of pig caused by virus breathes and Reproduction Disorder, it it is the worldwide a kind of Infectious Diseases of pig industry, mostly occur in temperature higher summer, autumn, spread speed is fast, the course of disease in a pig farm sustainable 1～2 month.Major part pig farm sickness rate up to more than 50%, mortality rate is up to 20%～50%, and serious may be up to 90%, if occur primary disease time again immunity swine Fever Vaccine, M & M can be higher.Pig immunity degradation, often secondary Porcine circovirus desease, Haemophilus parasuis, eperythrozoonosis, streptococcicosis etc. after occurring due to high-pathogenicity blue ear disease, make the state of an illness more complicated, treat more difficult.Pig blue-ear disease main manifestations is that high heat is delaied, and whole skin is rubescent, and sick pig ear, eyelet and the perianal that the course of disease is slightly long turns blue cyanosis, under abdomen and limb end even whole skin occur rubescent blue.Some appearance eye conjunctivitis, blepharoedema, exophthalmos, indivedual sick pig astasias, there is sample nervous symptoms of striking in extremity.In-pig is also miscarried, produces stillborn fetus phenomenon.Treat with antibiotic and sulfa drugs and produce little effect.When under ear and abdomen, cyanosis occurs in skin, mortality rate is high.
At present, the method for preventing and treating pig blue-ear disease is more, mainly uses Western medicine, immunoprophylaxis, Chinese herbal medicine etc. to prevent and treat.Wherein, spreading unchecked that Western medicine uses brings great potential safety hazard to Pork food, and drug residue has become as affects one of safe principal element of pork product.Immunoprophylaxis early stage results is better, however it is necessary that and repeatedly inoculates, troublesome poeration, and relatively costly, it is easy to cause stress；And there is dispute on Clinical practice in vaccination, it is impossible to large-scale promotion.Chinese herbal treatment is one of current main direction of studying.Formula as disclosed in patent of invention " preparation method of a kind of Chinese medicine composition treating pig blue-ear disease and this Chinese medicine composition " that the patent No. is CN201510673265.2 is Semen Euryales 10～25 parts, Fructus Forsythiae 8～10 parts, Rhizoma Coptidis 5～9 parts, Radix Bupleuri 7～13 parts, Radix Glycyrrhizae Preparata 10～20 parts, the Radix Paeoniae Alba 9～16 parts, 6～10 parts of Bulbus Allii, vegetable polysaccharides 20～30 parts, and described vegetable polysaccharides is prepared according to mass ratio 8～15: 7～10: 5～8 mixing by Aloe polysaccharide, astragalus polysaccharides and Radix Codonopsis polysaccharide；Formula as disclosed in patent of invention " a kind of Chinese medicine treating pig blue-ear disease " that the patent No. is CN201210484665.5 is: Cornu rhinocerotis 0.5 part, Radix Rehmanniae 5-6 part, Radix Ophiopogonis 3-6 part, profound three 4-6 part, Folium Isatidis: 3-5 part, Fructus Forsythiae 3-5 part, Herba Taraxaci 6-10 part, Flos Lonicerae 6-10 part, Radix Sophorae Tonkinensis 4-6 part, penetrate a 4-6 part, withered stalk 4-6 part, Radix Et Rhizoma Rhei 3-5 part, Radix Paeoniae Rubra 3-5 part, Radix Glycyrrhizae 2-4 part, Venenum Bufonis 0.3-0.5 part.But current Chinese herbal medicine is undesirable in medicine preparation effect, treatment is slow, the problems such as the course for the treatment of is long, and cure rate is low.
Summary of the invention
For solving above-mentioned technical problem, the invention provides and a kind of treat the Chinese prescription of pig blue-ear disease, manufacture method and using method.
The present invention is achieved by the following technical programs.
A kind of Chinese prescription treating pig blue-ear disease provided by the invention, including the raw material of following weight portion: Fructus Forsythiae 5-15 part, Bulbus Allii 5-15 part, Herba Taraxaci 5-15 part, Stigma Maydis 5-15 part, Gypsum Fibrosum 5-15 part, Herba Lophatheri 5-15 part, Flos Lonicerae 5-15 part, Radix Scutellariae 5-10 part, Radix Astragali 5-10 part, Radix Puerariae 5-15 part, Radix Paeoniae Alba 5-15 part, Folium Isatidis 5-15 part.
Further, including the raw material of following weight portion: Fructus Forsythiae 8-12 part, Bulbus Allii 10-15 part, Herba Taraxaci 10-15 part, Stigma Maydis 5-10 part, Gypsum Fibrosum 5-10 part, Herba Lophatheri 8-12 part, Flos Lonicerae 5-10 part, Radix Scutellariae 6-9 part, Radix Astragali 5-7 part, Radix Puerariae 10-15 part, Radix Paeoniae Alba 8-12 part, Folium Isatidis 8-12 part.
Further, including the raw material of following weight portion: Fructus Forsythiae 10 parts, 13 parts of Bulbus Allii, Herba Taraxaci 13 parts, Stigma Maydis 7 parts, 9 parts of Gypsum Fibrosum, Herba Lophatheri 10 parts, Flos Lonicerae 8 parts, Radix Scutellariae 8 parts, the Radix Astragali 6 parts, Radix Puerariae 14 parts, the Radix Paeoniae Alba 10 parts, Folium Isatidis 10 parts.
Meanwhile, present invention also offers the manufacture method of a kind of Chinese prescription treating pig blue-ear disease, it is characterised in that: its manufacture method is by all raw materials grind into powder respectively, then according to ratio mixes.
Meanwhile, the present invention also provides for the manufacture method of the Chinese prescription of another kind for the treatment of pig blue-ear disease, it is characterised in that: comprise the following steps:
1), after the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba are cut into slices, more than 2h is then soaked；Fructus Forsythiae, Radix Scutellariae soak more than 2h；
2) by the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae more than decatize 20min respectively；
3) Radix Astragali after decatize, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae and Herba Taraxaci, Stigma Maydis, Herba Lophatheri, Flos Lonicerae, Folium Isatidis are proportionally mixed to get mixture, grind to form powder, be subsequently adding the barms of 1%, sealed fermenting more than 2 days；
4), when using, respectively Bulbus Allii, Gypsum Fibrosum are ground to form powder, then according to ratio mixes with the mixture after fermentation, namely obtain this Chinese prescription.
Meanwhile, present invention also offers the using method of a kind of Chinese prescription treating pig blue-ear disease, this Chinese prescription adds use, make consumption be feed relative 1～3% in feedstuff to.
The beneficial effects of the present invention is: the present invention selects the compositions of Fructus Forsythiae, Bulbus Allii, Herba Taraxaci, Stigma Maydis, Gypsum Fibrosum, Herba Lophatheri, Flos Lonicerae, Radix Scutellariae, the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba and Folium Isatidis for treating pig blue-ear disease, each medicine effect can be made to produce synergism, in side all medicine phases and, play heat-clearing and toxic substances removing altogether, anti-inflammation, improve effect of immunity of organisms and resistance against diseases, the piglet and Adult Pig suffering from pig blue-ear disease is had obvious curative effect.It is shown experimentally that: taking piglet and the Adult Pig of Chinese prescription of the present invention, its reproductive and respiratory syndrome has obvious curative effect, and its effective percentage can reach more than 85%.
Detailed description of the invention
Technical scheme be described further below, but described in the scope claimed is not limited to.
Embodiment one
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 15kg, Bulbus Allii 5kg, Herba Taraxaci 15kg, Stigma Maydis 5kg, Gypsum Fibrosum 15kg, Herba Lophatheri 5kg, Flos Lonicerae 15kg, Radix Scutellariae 10kg, Radix Astragali 5kg, Radix Puerariae 15kg, Radix Paeoniae Alba 5kg, Folium Isatidis 15kg.Its manufacture method is by all raw materials grind into powder respectively, then according to ratio mixes.
This Chinese prescription adds use, make consumption be feed relative 1% in feedstuff to.
Embodiment two
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 5kg, Bulbus Allii 15kg, Herba Taraxaci 5kg, Stigma Maydis 15kg, Gypsum Fibrosum 5kg, Herba Lophatheri 15kg, Flos Lonicerae 5kg, Radix Scutellariae 10kg, Radix Astragali 5kg, Radix Puerariae 15kg, Radix Paeoniae Alba 5kg, Folium Isatidis 15kg.Its manufacture method is by all raw materials grind into powder respectively, then according to ratio mixes.
This Chinese prescription adds use, make consumption be feed relative 3% in feedstuff to.
Embodiment three
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 10kg, Bulbus Allii 13kg, Herba Taraxaci 13kg, Stigma Maydis 7kg, Gypsum Fibrosum 9kg, Herba Lophatheri 10kg, Flos Lonicerae 8kg, Radix Scutellariae 8kg, Radix Astragali 6kg, Radix Puerariae 14kg, Radix Paeoniae Alba 10kg, Folium Isatidis 10kg.Its manufacture method is by all raw materials grind into powder respectively, then according to ratio mixes.
This Chinese prescription adds use, make consumption be feed relative 2% in feedstuff to.
Embodiment four
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 15kg, Bulbus Allii 5kg, Herba Taraxaci 15kg, Stigma Maydis 5kg, Gypsum Fibrosum 15kg, Herba Lophatheri 5kg, Flos Lonicerae 15kg, Radix Scutellariae 10kg, Radix Astragali 5kg, Radix Puerariae 15kg, Radix Paeoniae Alba 5kg, Folium Isatidis 15kg.Its processing technology comprises the following steps:
1), after the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba are cut into slices, 2h is then soaked；Fructus Forsythiae, Radix Scutellariae soak 2h；
2) by the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae decatize 20min respectively；
3) Radix Astragali after decatize, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae and Herba Taraxaci, Stigma Maydis, Herba Lophatheri, Flos Lonicerae, Folium Isatidis are proportionally mixed to get mixture, grind to form powder, be subsequently adding the barms of 1%, sealed fermenting 2 days；Described barms can be commercially available any barms；
4), when using, respectively Bulbus Allii, Gypsum Fibrosum are ground to form powder, then according to ratio mixes with the mixture after fermentation, namely obtain this Chinese prescription.
This Chinese prescription adds use, make consumption be feed relative 1% in feedstuff to.
Embodiment five
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 5kg, Bulbus Allii 15kg, Herba Taraxaci 5kg, Stigma Maydis 15kg, Gypsum Fibrosum 5kg, Herba Lophatheri 15kg, Flos Lonicerae 5kg, Radix Scutellariae 10kg, Radix Astragali 5kg, Radix Puerariae 15kg, Radix Paeoniae Alba 5kg, Folium Isatidis 15kg.Its processing technology comprises the following steps:
1), after the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba are cut into slices, 4h is then soaked；Fructus Forsythiae, Radix Scutellariae soak 4h；
2) by the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae decatize 50min respectively；
3) Radix Astragali after decatize, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae and Herba Taraxaci, Stigma Maydis, Herba Lophatheri, Flos Lonicerae, Folium Isatidis are proportionally mixed to get mixture, grind to form powder, be subsequently adding the barms of 1%, sealed fermenting 3 days；Described barms can be commercially available any barms；
4), when using, respectively Bulbus Allii, Gypsum Fibrosum are ground to form powder, then according to ratio mixes with the mixture after fermentation, namely obtain this Chinese prescription.
This Chinese prescription adds use, make consumption be feed relative 3% in feedstuff to.
Embodiment six
A kind of Chinese prescription treating pig blue-ear disease that the present embodiment provides, including following raw material: Fructus Forsythiae 10kg, Bulbus Allii 13kg, Herba Taraxaci 13kg, Stigma Maydis 7kg, Gypsum Fibrosum 9kg, Herba Lophatheri 10kg, Flos Lonicerae 8kg, Radix Scutellariae 8kg, Radix Astragali 6kg, Radix Puerariae 14kg, Radix Paeoniae Alba 10kg, Folium Isatidis 10kg.Its processing technology comprises the following steps:
1), after the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba are cut into slices, 4h is then soaked；Fructus Forsythiae, Radix Scutellariae soak 4h；
2) by the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae decatize 50min respectively；
3) Radix Astragali after decatize, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae and Herba Taraxaci, Stigma Maydis, Herba Lophatheri, Flos Lonicerae, Folium Isatidis are proportionally mixed to get mixture, grind to form powder, be subsequently adding the barms of 1%, sealed fermenting 3 days；Described barms can be commercially available any barms；
4), when using, respectively Bulbus Allii, Gypsum Fibrosum are ground to form powder, then according to ratio mixes with the mixture after fermentation, namely obtain this Chinese prescription.
This Chinese prescription adds use, make consumption be feed relative 1～3% in feedstuff to.
In order to prove the technique effect of the present invention further, the present invention also provides for following experimental example:
Test example 1:
1, test packet: choosing suffers from piglet and each 100 of the Adult Pig of reproductive and respiratory syndrome, amounts to 200, male and female dual-purpose is divided into piglet group and Adult Pig group.
Piglet group being randomly divided into a1, b1, c1, d1 group, no group 25, wherein a1 group is blank group, and b1 is for using antibiotic group, and c1 is the Chinese prescription group using embodiment three, and d1 is the Chinese prescription group using embodiment six.
Adult Pig group being randomly divided into a2, b2, c2, d2 group, no group 25, wherein a2 group is blank group, and b2 is for using antibiotic group, and c2 is the Chinese prescription group using embodiment three, and d2 is the Chinese prescription group using embodiment six.
2, diagnostic criteria:
Body temperature up to more than 40 DEG C, dyspnea, sometimes in ventral breathing, loss of appetite or useless absolutely, diarrhoea, peel off, stay alone or huddling together mutually, by hair slightly disorderly, muscular tremor, the unstable ataxia of walking, extremity abduction, posterior paralysis, gradual become thin, blepharoedema.Some piglets performance mouth and nose are very itched, and common nose dish, mouth end are on colony house friction wall hurdle, and nose has batter shape or watery secretion.
3, Therapeutic Method:
Antibiotic often daily 3～5 times, piglet does not have head to be administered 5ml every time, and Adult Pig does not have head to be administered 20ml every time, is used in conjunction 14 days.Chinese prescription is mixed in feedstuff, conventionally feeds, and each mixed volume is the 2% of feedstuff gross mass, uses 14 days continuously, within the 15th day, observes treatment situation.
4, therapeutic outcome
Piglet is suffered from the therapeutical effect of pig blue-ear disease by table 1 Chinese prescription
Adult Pig is suffered from the therapeutical effect of pig blue-ear disease by table 2 Chinese prescription
| Group | Metering | Invalid head number | Cure rate |
| a2 | —— | 20 | |
| b2 | 20ml/ head | 12 | 68% |
| c2 | 2% (forage volume) | 3 | 88% |
| d2 | 2% (forage volume) | 3 | 88% |
Note: efficacy assessment standard:
Invalid: not reach improvement standard or death；Cure: return to one's perfect health.
Being shown by table 1 and table 2 data, taking piglet and the Adult Pig of Chinese prescription of the present invention, its reproductive and respiratory syndrome has obvious curative effect, and its effective percentage can reach more than 85%.
Technique scheme only embodies the optimal technical scheme of technical solution of the present invention, and some variations that some of which part is likely to make by those skilled in the art all embody principles of the invention, belong within protection scope of the present invention.
Claims (6)
1. the Chinese prescription treating pig blue-ear disease, it is characterised in that: include the raw material of following weight portion: Fructus Forsythiae 5-15 part, Bulbus Allii 5-15 part, Herba Taraxaci 5-15 part, Stigma Maydis 5-15 part, Gypsum Fibrosum 5-15 part, Herba Lophatheri 5-15 part, Flos Lonicerae 5-15 part, Radix Scutellariae 5-10 part, Radix Astragali 5-10 part, Radix Puerariae 5-15 part, Radix Paeoniae Alba 5-15 part, Folium Isatidis 5-15 part.
2. the Chinese prescription treating pig blue-ear disease as claimed in claim 1, it is characterised in that: include the raw material of following weight portion: Fructus Forsythiae 8-12 part, Bulbus Allii 10-15 part, Herba Taraxaci 10-15 part, Stigma Maydis 5-10 part, Gypsum Fibrosum 5-10 part, Herba Lophatheri 8-12 part, Flos Lonicerae 5-10 part, Radix Scutellariae 6-9 part, Radix Astragali 5-7 part, Radix Puerariae 10-15 part, Radix Paeoniae Alba 8-12 part, Folium Isatidis 8-12 part.
3. the Chinese prescription treating pig blue-ear disease as claimed in claim 1, it is characterised in that: include the raw material of following weight portion: Fructus Forsythiae 10 parts, 13 parts of Bulbus Allii, Herba Taraxaci 13 parts, Stigma Maydis 7 parts, 9 parts of Gypsum Fibrosum, Herba Lophatheri 10 parts, Flos Lonicerae 8 parts, Radix Scutellariae 8 parts, the Radix Astragali 6 parts, Radix Puerariae 14 parts, the Radix Paeoniae Alba 10 parts, Folium Isatidis 10 parts.
4. the manufacture method of the Chinese prescription of the treatment pig blue-ear disease as described in claims 1 to 3, it is characterised in that: its manufacture method is by all raw materials grind into powder respectively, then according to ratio mixes.
5. the manufacture method of the Chinese prescription of the treatment pig blue-ear disease as described in claims 1 to 3, it is characterised in that: comprise the following steps:
1), after the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba are cut into slices, more than 2h is then soaked；Fructus Forsythiae, Radix Scutellariae soak more than 2h；
2) by the Radix Astragali, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae more than decatize 20min respectively；
3) Radix Astragali after decatize, Radix Puerariae, the Radix Paeoniae Alba, Fructus Forsythiae, Radix Scutellariae and Herba Taraxaci, Stigma Maydis, Herba Lophatheri, Flos Lonicerae, Folium Isatidis are proportionally mixed to get mixture, grind to form powder, be subsequently adding the barms of 1%, sealed fermenting more than 2 days；
4), when using, respectively Bulbus Allii, Gypsum Fibrosum are ground to form powder, then according to ratio mixes with the mixture after fermentation, namely obtain this Chinese prescription.
6. the using method of the Chinese prescription of the treatment pig blue-ear disease as described in claims 1 to 3, it is characterised in that: this Chinese prescription adds use, make consumption be feed relative 1～3% in feedstuff to.
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| CN107441373A (en) * | 2017-08-08 | 2017-12-08 | 上海朝翔生物技术有限公司 | A kind of natural galenical of efficiently preventing and treating pig blue-ear disease and preparation method thereof |
| CN110179798A (en) * | 2019-06-28 | 2019-08-30 | 河南牧业经济学院 | Application of the G4 ligand PhenDC3 in the drug for preparing anti-porcine reproductive and respiratory syndrome virus |
| CN112220867A (en) * | 2020-11-16 | 2021-01-15 | 河南豫商生物科技集团有限公司 | Fermented traditional Chinese medicine for preventing and treating blue-ear disease and preparation method and application thereof |
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| CN107441373A (en) * | 2017-08-08 | 2017-12-08 | 上海朝翔生物技术有限公司 | A kind of natural galenical of efficiently preventing and treating pig blue-ear disease and preparation method thereof |
| CN110179798A (en) * | 2019-06-28 | 2019-08-30 | 河南牧业经济学院 | Application of the G4 ligand PhenDC3 in the drug for preparing anti-porcine reproductive and respiratory syndrome virus |
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| CN112220867A (en) * | 2020-11-16 | 2021-01-15 | 河南豫商生物科技集团有限公司 | Fermented traditional Chinese medicine for preventing and treating blue-ear disease and preparation method and application thereof |
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