CN112618648B - Traditional Chinese medicine composition for rapidly abating fever and preparation method thereof - Google Patents

Traditional Chinese medicine composition for rapidly abating fever and preparation method thereof Download PDF

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CN112618648B
CN112618648B CN202011568049.9A CN202011568049A CN112618648B CN 112618648 B CN112618648 B CN 112618648B CN 202011568049 A CN202011568049 A CN 202011568049A CN 112618648 B CN112618648 B CN 112618648B
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李玲
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Abstract

The invention discloses a traditional Chinese medicine composition for fast defervescing and a preparation method thereof, relating to the technical field of defervescing traditional Chinese medicine compositions, wherein the traditional Chinese medicine composition for fast defervescing comprises the following raw material components: radix Scutellariae, radix rehmanniae, Gypsum Fibrosum, rhizoma Coptidis, fructus Lycii, radix bupleuri, cortex Phellodendri, fructus Ligustri Lucidi, radix Saposhnikoviae, fructus Gardeniae, rhizoma anemarrhenae, radix Angelicae Dahuricae, radix Gentianae, radix astragali, ramulus Cinnamomi, semen Cassiae, Poria, herba Schizonepetae, radix Puerariae, and radix Clematidis. The traditional Chinese medicine composition for rapidly abating fever provided by the invention adopts pure natural traditional Chinese medicines as raw material components, is reasonably matched according to the traditional Chinese medicine compatibility, is green and environment-friendly, has no toxicity or harm to human bodies, has no side effect, can abate fever rapidly, is not slow or slow, is not urgent or dry, abates fever without rebound, can also consolidate the five internal organs and six internal organs, strengthen the physique, prevent internal fever from damaging the physique, avoid other diseases and save the cost.

Description

Traditional Chinese medicine composition for rapidly abating fever and preparation method thereof
Technical Field
The invention relates to the technical field of antipyretic traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for rapidly abating fever and a preparation method thereof.
Background
Fever refers to the increase of body temperature beyond the normal range caused by pyrogen or various causes. Under normal conditions, the heat production and the heat dissipation of the human body keep dynamic balance. From the perspective of traditional Chinese medicine, typhoid fever, diarrhea and restlessness are also caused by cold in the middle and yang deficiency. Or fever with profuse discharge and profuse decline of the lung-qi, manifested as restlessness, exterior yang dispersing and interior yang collapse, all the cases are also killed.
Most of the existing antipyretic medicines are western medicines which have antipyretic effects but have prominent toxic and side effects, and can be taken only occasionally and not for a long time. For example, aspirin and ibuprofen have good antipyretic effect, but long-term use can cause damage to liver and kidney. And the fever is easy to rebound after the western medicine is taken, and the fever needs to be treated repeatedly. The traditional Chinese medicines for defervescing are only limited to small bupleurum decoction, three-yellow cathartic decoction, honeysuckle granules, isatis root granules, scutellaria granules, prunella vulgaris and chrysanthemum granules and the like, have slow defervescing speed, cannot fix the five internal organs and six internal organs simultaneously, are balanced integrally, and can strengthen the body resistance and nourish the body.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition for rapidly abating fever and a preparation method thereof.
The traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 3-7 parts of scutellaria baicalensis, 40-60 parts of radix rehmanniae, 20-40 parts of gypsum, 1-3 parts of coptis chinensis, 3-7 parts of medlar, 10-20 parts of radix bupleuri, 10-20 parts of cortex phellodendri, 15-25 parts of glossy privet fruit, 2-4 parts of radix sileris, 5-15 parts of gardenia, 20-30 parts of rhizoma anemarrhenae, 2-4 parts of radix angelicae, 5-9 parts of felwort, 20-40 parts of astragalus membranaceus, 1-3 parts of cassia twig, 15-25 parts of semen cassiae, 10-20 parts of poria cocos, 2-4 parts of schizonepeta, 10-20 parts of radix puerariae and 2-4 parts of radix clematidis.
Preferably, 4-6 parts of scutellaria baicalensis, 45-55 parts of radix rehmanniae, 25-35 parts of gypsum, 1.5-2.5 parts of coptis chinensis, 4-6 parts of medlar, 13-17 parts of radix bupleuri, 13-17 parts of phellodendron, 13-22 parts of glossy privet fruit, 2.5-3.5 parts of divaricate saposhnikovia root, 8-12 parts of gardenia, 23-27 parts of rhizoma anemarrhenae, 2.5-3.5 parts of angelica dahurica, 6-8 parts of gentian, 25-35 parts of astragalus mongholicus, 1.5-2.5 parts of cassia twig, 18-22 parts of semen cassiae, 13-18 parts of poria cocos, 2.5-3.5 parts of schizonepeta, 13-17 parts of radix puerariae and 2.5-3.5 parts of radix clematidis.
More preferably, the traditional Chinese medicine composition comprises 5 parts of scutellaria baicalensis, 50 parts of radix rehmanniae, 30 parts of gypsum, 2 parts of coptis chinensis, 5 parts of medlar, 15 parts of radix bupleuri, 15 parts of golden cypress, 20 parts of glossy privet fruit, 3 parts of divaricate saposhnikovia root, 10 parts of cape jasmine fruit, 25 parts of rhizoma anemarrhenae, 3 parts of radix angelicae, 7 parts of gentian, 30 parts of astragalus membranaceus, 2 parts of cassia twig, 20 parts of semen cassiae, 15 parts of poria cocos, 3 parts of schizonepeta, 15 parts of radix puerariae and 3 parts of radix clematidis.
More preferably, 4 parts of scutellaria baicalensis, 45 parts of radix rehmanniae, 25 parts of gypsum, 1.5 parts of coptis chinensis, 4 parts of medlar, 13 parts of radix bupleuri, 13 parts of golden cypress, 13 parts of glossy privet fruit, 2.5 parts of divaricate saposhnikovia root, 8 parts of cape jasmine, 23 parts of rhizoma anemarrhenae, 2.5 parts of radix angelicae, 6 parts of felwort, 25 parts of astragalus membranaceus, 1.5 parts of cassia twig, 18 parts of semen cassiae, 13 parts of poria cocos, 2.5 parts of schizonepeta, 13 parts of radix puerariae and 2.5 parts of radix clematidis.
More preferably, the traditional Chinese medicine composition comprises 6 parts of scutellaria baicalensis, 55 parts of radix rehmanniae, 35 parts of gypsum, 2.5 parts of coptis chinensis, 6 parts of medlar, 17 parts of radix bupleuri, 17 parts of golden cypress, 22 parts of glossy privet fruit, 3.5 parts of divaricate saposhnikovia root, 12 parts of cape jasmine, 27 parts of rhizoma anemarrhenae, 3.5 parts of radix angelicae, 8 parts of felwort, 35 parts of astragalus membranaceus, 2.5 parts of cassia twig, 22 parts of semen cassiae, 18 parts of poria cocos, 3.5 parts of schizonepeta, 17 parts of radix puerariae and 3.5 parts of radix clematidis.
The preparation method of the traditional Chinese medicine composition for rapidly abating fever comprises the following steps:
s1, screening out high-quality raw material components, cleaning, draining water, and drying to obtain dried raw material components;
s2, crushing the dried raw material components to obtain raw material component powder;
s3, adding water into the raw material component powder, soaking, heating and extracting, filtering, repeatedly extracting for 5 times, mixing water extracting solutions obtained by 5 times of extraction, and preparing a mixed water extracting solution and residues;
s4, performing supercritical CO treatment on the residues2Extracting to obtain supercritical CO2Extracting with mixed water solution of supercritical CO2The extract liquid is fed intoMixing, and concentrating under reduced pressure to obtain the Chinese medicinal composition with rapid antipyretic effect.
Preferably, in step S3, the mass ratio of the raw material component powder to water is 1: 15-20 parts of; the heating extraction is heating to 100-120 ℃ for 1 hour.
Preferably, in step S4, the supercritical CO2The extraction conditions are 45MPa pressure and 45 ℃.
Preferably, in step S4, the mixture is concentrated under reduced pressure to a relative density of 0.9-1.3 at-0.08 to-0.1 MPa.
The invention has the following functions and effects:
scutellaria baicalensis: cold in nature and bitter in taste. It enters lung meridian, gallbladder meridian, spleen meridian, large intestine meridian, and small intestine meridian. The function is as follows: clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-warm syndrome, chest distress, emesis, dampness-heat distention and fullness, dysentery, jaundice, cough due to lung-heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Radix rehmanniae: cold in nature and sweet in taste. They enter heart, liver and kidney meridians. The function is as follows: clearing heat and cooling blood, nourishing yin and promoting fluid production. It can be used for treating fever, crimson tongue, polydipsia, yin deficiency, internal heat, bone steaming, fatigue, internal heat, diabetes, hematemesis, epistaxis, speckle, and erythra.
Gypsum: big and cold in nature, sweet and pungent in flavor. It enters lung and stomach meridians. The function is as follows: clear heat and lower fire, relieve restlessness and quench thirst. Can be used for treating common cold, fever, polydipsia, lung heat, cough, asthma, excessive stomach fire, headache, and toothache.
Coptis chinensis: bitter taste and cold nature. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. The function is as follows: clear heat and dry dampness, purge fire and remove toxicity. Mainly treats damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart-fire, vexation and insomnia, palpitation and restlessness, blood heat and hematemesis and epistaxis, conjunctival congestion, toothache, diabetes, carbuncle and swelling and sore; it is used externally to treat eczema, eczema and purulent ear canal.
Medlar: mild in nature and sweet in taste. It enters liver and kidney meridians. The function is as follows: nourishing liver and kidney, replenishing vital essence and improving eyesight. Can be used for treating consumptive disease, essence deficiency, soreness of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision.
Bupleurum root: slightly cold in nature and bitter in taste. It enters liver meridian, gallbladder meridian and lung meridian. The function is as follows: harmonize exterior and interior, soothe liver and raise yang. Can be used for treating common cold, fever, pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.
Phellodendron bark: cold in nature and bitter in taste. It enters kidney and bladder meridians. The function is as follows: clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substance, and treating sore. Can be used for treating dysentery due to damp-heat, jaundice, leukorrhagia, stranguria due to heat, hectic fever due to yin-deficiency, night sweat, and spermatorrhea; sores, ulcers, swelling, eczema and pruritus.
Glossy privet fruit: cool in nature, sweet and bitter in taste. It enters liver and kidney meridians. The function is as follows: nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating tinnitus, deafness, dizziness, soreness of waist and knees, and premature gray hair due to liver and kidney yin deficiency.
Wind prevention: warm in nature, sweet and pungent in flavor. It enters bladder meridian, liver meridian and spleen meridian. The function is as follows: relieving exterior syndrome, dispelling pathogenic wind, and removing dampness. Can be used for treating common cold, headache, fever, anidrosis, rheumatalgia, spasm of limbs, skin pruritus due to rheumatism, and tetanus
Gardenia: cold in nature and bitter in taste. They enter heart meridian, lung meridian and triple energizer meridian. The function is as follows: purging pathogenic fire, relieving restlessness, clearing away heat, promoting urination, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain. Mainly treats warm diseases such as heat stagnation in the heart and chest, vexation, depression, restlessness and uneasiness, and uneasy sleep; damp-heat stagnation of liver and gallbladder, jaundice, fever, scanty and brownish urine; hematemesis, epistaxis, hematuria, traumatic injury, scald, burn, etc. due to recklessly blood flow due to blood heat.
Rhizoma anemarrhenae: bitter taste and cold nature. It enters lung, stomach and kidney meridians. The function is as follows: clear heat and purge fire, nourish yin and moisten dryness. Can be used for treating fever polydipsia, lung heat dry cough, hectic fever due to yin-deficiency, internal heat diabetes, and constipation due to intestinal dryness.
Radix angelicae: warm in nature and pungent in flavor. It enters stomach meridian, large intestine meridian and lung meridian. The function is as follows: dispelling pathogenic wind, removing dampness, inducing resuscitation, relieving pain, relieving swelling, and expelling pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.
Gentian: cold in nature and bitter in taste. It enters liver meridian and gallbladder meridian. The function is as follows: clearing liver fire, removing dampness and heat, and invigorating stomach. Can be used for treating conjunctival congestion, dizziness, deafness, ear swelling, hypochondriac pain, bitter taste, sore throat, epilepsy, convulsion, damp-heat, skin sore, eczema, pudendal swelling, pudendal pruritus, stranguria with urine, and anorexia.
Astragalus root: slightly warm in nature and sweet in taste. It enters spleen and lung meridians. The function is as follows: invigorating qi, consolidating superficial resistance, promoting urination, expelling toxin, expelling pus, and promoting granulation. Can be used for treating short breath, palpitation, asthenia, collapse, spontaneous perspiration, night sweat, asthenia, edema, chronic nephritis, chronic diarrhea, proctoptosis, uterine prolapse, carbuncle, cellulitis, intractable wound, infantile bronchial asthma, chronic hepatitis B, chronic nephritis, and viral myocarditis.
Cassia twig: pungent and sweet in flavor and warm in nature. It enters bladder meridian, heart meridian and lung meridian. The function is as follows: releasing exterior and relieving exterior syndrome, warming meridians and promoting blood circulation, supporting yang to transform qi, and calming the adverse-rising energy, and belongs to the pungent-warm exterior-releasing herbs. Can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.
Cassia seed: slightly cold in nature, bitter and sweet in taste. It enters liver meridian, kidney meridian and large intestine meridian. The function is as follows: clearing heat, improving eyesight, moistening intestine and relaxing bowels. Can be used for treating conjunctival congestion, swelling and pain, photophobia, lacrimation and nyctalopia due to excessive fire or wind-heat in liver channel; constipation due to heat accumulation and constipation due to intestinal dryness; dizziness and headache due to hyperactivity of liver yang.
Tuckahoe, poria cocos: mild in nature, sweet and bland in flavor. They enter heart, lung, spleen and kidney meridians. The function is as follows: induce diuresis and drain dampness, invigorate spleen and calm heart. It can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Herba schizonepetae: slightly warm in nature, bitter and pungent in flavor. It enters lung meridian and bladder meridian. The function is as follows: dispel wind and remove dampness, kill parasites and relieve itching, and promote blood circulation to reduce swelling. Can be used for treating ancylostomiasis, ascariasis, enterobiasis, head louse, skin eczema, scabies, rheumatalgia, amenorrhea, dysmenorrhea, aphtha of the mouth and tongue, sore throat, traumatic injury, and snake and insect bite.
Kudzu root: cool in nature, sweet and pungent in flavor. It enters spleen and stomach meridians. The function is as follows: expelling pathogenic factors from muscles, relieving fever, promoting salivation, promoting eruption, invigorating yang, and relieving diarrhea. It can be used for treating typhoid fever, headache, stiffness, dysphoria with smothery sensation, diabetes, diarrhea, dysentery, macula, hypertension, angina pectoris, deafness, etc.
Clematis root: warm in nature, pungent and salty in flavor. It enters bladder meridian. The function is as follows: dispelling pathogenic wind, removing dampness, dredging collaterals, and relieving pain. It can be used for treating rheumatic arthralgia, numbness of limbs, spasm of tendons and vessels, difficulty in flexion and extension, and bone sticking throat.
The compatibility principle and the antipyretic principle of the raw material components of the invention are as follows:
baikal skullcap root, coptis root, phellodendron bark, cape jasmine, gentian and gypsum are monarch drugs for clearing internal heat of internal organs. Astragalus root, tuckahoe, dried rehmannia root, medlar, glossy privet fruit and rhizoma anemarrhenae are used as ministerial drugs for nourishing yin and qi. Radix astragali and poria cocos are added to assist vital qi and disperse wind-cold evil easily from inside to outside as ministerial drugs, and the radix rehmanniae, the medlar, the glossy privet fruit and the rhizoma anemarrhenae are added to nourish yin and blood and prevent true yin from being lost due to fever, so the Chinese herbal medicine is ministerial drug. Radix puerariae, honeysuckle, radix bupleuri, cassia twig, radix sileris, semen cassiae, liquorice, radix angelicae, herba schizonepetae and radix clematidis are used as adjuvant and guiding agents, which are good at opening the ghost door and show sweat state, and wind-cold evil is induced to permeate from the hair orifices slowly, so that wind-cold is relieved. Heat is dissipated when wind-cold is relieved and the exterior is obstructed. Baikal skullcap root, coptis root, phellodendron bark, cape jasmine fruit and gentian root clear and purge fire heat, so that internal stagnated heat is cleared and discharged from the body, and when internal heat is dispersed and internal heat is cleared, wind-cold stagnation is caused, and fire pathogen in internal blazing fire is naturally eliminated, so that heat can be relieved and the body is safe.
The provided traditional Chinese medicine composition for rapidly abating fever works on the principle of fever, clears heat of internal organs of the five viscera and the six hollow organs without forgetting to nourish yin and liquid, eliminates pathogenic factors and dispels cold without forgetting to support healthy qi, has enough healthy qi, can not dry the pathogenic factors, can easily disperse and easily dispel pathogenic wind-cold, and can prevent the loss of true yin and body constitution damage due to fever, so that the fever abates without damaging yin and the body constitution is easy to recover.
The invention has the beneficial effects that:
(1) the traditional Chinese medicine composition for rapidly abating fever provided by the invention adopts pure natural traditional Chinese medicines as raw material components, is reasonably matched according to the traditional Chinese medicine compatibility, is green and environment-friendly, has no toxicity or harm to human bodies, has no side effect, can abate fever rapidly, is not slow or slow, is not urgent or dry, abates fever without rebound, can also consolidate the five internal organs and six internal organs, strengthen the physique, prevent internal fever from damaging the physique, avoid other diseases and save the cost.
(2) The traditional Chinese medicine composition for rapidly abating fever provided by the invention is used for treating exogenous wind-cold fever, and can abate fever rapidly, and can be taken for 2-3 times for half an hour for low fever, and can abate fever slowly after abating fever for 6-10 times for high fever, and the fever can abate without rebound after abating fever.
(3) The preparation method of the traditional Chinese medicine composition for rapidly abating fever provided by the invention is simple to operate, the raw materials are easy to obtain, the technology is stable, and the prepared traditional Chinese medicine composition for rapidly abating fever has an excellent treatment effect and extremely high commercial value.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Example 1
A traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 5 parts of scutellaria baicalensis, 50 parts of radix rehmanniae, 30 parts of gypsum, 2 parts of coptis chinensis, 5 parts of medlar, 15 parts of radix bupleuri, 15 parts of golden cypress, 20 parts of glossy privet fruit, 3 parts of divaricate saposhnikovia root, 10 parts of cape jasmine, 25 parts of rhizoma anemarrhenae, 3 parts of radix angelicae, 7 parts of gentian, 30 parts of astragalus mongholicus, 2 parts of cassia twig, 20 parts of semen cassiae, 15 parts of poria cocos, 3 parts of schizonepeta, 15 parts of radix puerariae and 3 parts of radix clematidis.
The preparation method of the traditional Chinese medicine composition for rapidly abating fever comprises the following steps:
s1, screening out high-quality raw material components, cleaning, draining water, and drying to obtain dried raw material components;
s2, crushing the dried raw material components to obtain raw material component powder;
s3, adding water into the raw material component powder, soaking, heating and extracting, filtering, repeatedly extracting for 5 times, mixing water extracting solutions obtained by 5 times of extraction, and preparing a mixed water extracting solution and residues;
s4, performing supercritical CO treatment on the residues2Extracting to obtain supercritical CO2Extracting with mixed water solution of supercritical CO2Mixing the extractive solutions, and concentrating under reduced pressure to obtain the final productA Chinese medicinal composition for relieving fever.
In step S3, the mass ratio of the raw material component powder to water is 1: 20; the heating extraction is heating to 100-120 ℃ for 1 hour.
In step S4, the supercritical CO is2The extraction conditions are 45MPa pressure and 45 ℃.
In step S4, the mixture is concentrated to a relative density of 1.2 under the reduced pressure of-0.08 to-0.1 MPa.
Example 2
A traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 4 parts of scutellaria baicalensis, 45 parts of radix rehmanniae, 25 parts of gypsum, 1.5 parts of coptis chinensis, 4 parts of medlar, 13 parts of radix bupleuri, 13 parts of golden cypress, 13 parts of glossy privet fruit, 2.5 parts of divaricate saposhnikovia root, 8 parts of cape jasmine fruit, 23 parts of rhizoma anemarrhenae, 2.5 parts of radix angelicae, 6 parts of gentian, 25 parts of astragalus mongholicus, 1.5 parts of cassia twig, 18 parts of semen cassiae, 13 parts of poria cocos, 2.5 parts of schizonepeta, 13 parts of radix puerariae and 2.5 parts of radix clematidis.
The preparation method of the traditional Chinese medicine composition for rapidly abating fever comprises the following steps:
s1, screening out high-quality raw material components, cleaning, draining water, and drying to obtain dried raw material components;
s2, crushing the dried raw material components to obtain raw material component powder;
s3, adding water into the raw material component powder, soaking, heating and extracting, filtering, repeatedly extracting for 5 times, mixing water extracting solutions obtained by 5 times of extraction, and preparing a mixed water extracting solution and residues;
s4, performing supercritical CO treatment on the residues2Extracting to obtain supercritical CO2Extracting with mixed water solution of supercritical CO2Mixing the extractive solutions, and concentrating under reduced pressure to obtain the Chinese medicinal composition with rapid antipyretic effect.
In step S3, the mass ratio of the raw material component powder to water is 1: 20; the heating extraction is heating to 100-120 ℃ for 1 hour.
In step S4, the supercritical CO is2The extraction condition is pressure of 45MPa, temperature 45 ℃.
In step S4, the mixture is concentrated to a relative density of 1.2 under the reduced pressure of-0.08 to-0.1 MPa.
Example 3
A traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 6 parts of scutellaria baicalensis, 55 parts of radix rehmanniae, 35 parts of gypsum, 2.5 parts of coptis chinensis, 6 parts of medlar, 17 parts of radix bupleuri, 17 parts of golden cypress, 22 parts of glossy privet fruit, 3.5 parts of divaricate saposhnikovia root, 12 parts of cape jasmine fruit, 27 parts of rhizoma anemarrhenae, 3.5 parts of radix angelicae, 8 parts of gentian, 35 parts of astragalus mongholicus, 2.5 parts of cassia twig, 22 parts of semen cassiae, 18 parts of poria cocos, 3.5 parts of schizonepeta, 17 parts of radix puerariae and 3.5 parts of radix clematidis.
The preparation method of the traditional Chinese medicine composition for rapidly abating fever comprises the following steps:
s1, screening out high-quality raw material components, cleaning, draining water, and drying to obtain dried raw material components;
s2, crushing the dried raw material components to obtain raw material component powder;
s3, adding water into the raw material component powder, soaking, heating and extracting, filtering, repeatedly extracting for 5 times, mixing water extracting solutions obtained by 5 times of extraction, and preparing a mixed water extracting solution and residues;
s4, performing supercritical CO treatment on the residues2Extracting to obtain supercritical CO2Extracting with mixed water solution of supercritical CO2Mixing the extractive solutions, and concentrating under reduced pressure to obtain the Chinese medicinal composition with rapid antipyretic effect.
In step S3, the mass ratio of the raw material component powder to water is 1: 20; the heating extraction is heating to 100-120 ℃ for 1 hour.
In step S4, the supercritical CO is2The extraction conditions are 45MPa pressure and 45 ℃.
In step S4, the mixture is concentrated to a relative density of 1.2 under the reduced pressure of-0.08 to-0.1 MPa.
Test examples
The patients with local wind-cold fever are selected to take the traditional Chinese medicine composition for quickly abating fever prepared in the embodiment 1 of the invention, and the effect is recorded.
The cases are as follows:
1. some Cao, 1.5 years old, male, fever 3-4 days, about 39 degrees, no cough, thirst, hang water, use Western medicine to defervesce, rebound after defervesce, use the Chinese medicinal composition of fast defervesce made in example 1 4 times, 10ml each time, the fever is completely withdrawn, but not rebound.
2. Cao Zhi is 1 year old and has fever of 39 degrees, and the quick antipyretic Chinese medicinal composition prepared in example 1 is used for 3 times, 10ml each time, and the fever is relieved without rebound.
3. In the case of the traditional Chinese medicine composition for quickly abating fever prepared in the example 1, the heat is abated completely by 1 time and 10ml in the case of the heat of the scholar, 1 and half years old and 39 degrees of fever.
4. After drinking a certain amount of Mei, women and adults with fever of more than 39 degrees, the quick-fever-reducing traditional Chinese medicine composition prepared in the embodiment 1 is used for 1 time and 20ml, and after three hours, the quick-fever-reducing traditional Chinese medicine composition prepared in the embodiment 1 is used for 1 time and 20ml, and then the patient can be relieved by profuse sweating, and the next morning, the fever can be relieved for an peace and the patient can normally go to work.
5. In the case of 6 years old men, the fever is more than 38 degrees, and the quick antipyretic Chinese medicinal composition prepared in example 1 is used for 3 times, 10ml each time, namely, good, and the people can normally go to school the next day.
6. Li Yi and women, more than 1 year old, generate heat at about 39 degrees at night, ventilate heat to the whole body, take 10ml of the quick-acting antipyretic Chinese medicinal composition prepared in example 1 immediately, observe that after half a clock, the heat is abated, children are not vexed, take 10ml of the quick-acting antipyretic Chinese medicinal composition prepared in example 1 again at night, 2 times for one clock, the next day, the heat is abated basically, then take again in 2 days, the heat is abated completely after two days, and pathogenic qi is eliminated completely.
7. Deng is, female, 3 years old, fever and cough, the traditional Chinese medicine composition for quickly abating fever prepared in example 1 is used for 3 times, 10ml is used for each time, fever abates, rebound does not occur, and cough is also good.
8. Li Yi, 13 years old, male, read books and stay in school, continuously take two days of fever, take western medicine for bringing back and high fever, accompany with nose bleeding, take 20ml of the traditional Chinese medicine composition for bringing back fever rapidly prepared in example 1, make head comfortable after 10 minutes, and take 20ml of the traditional Chinese medicine composition for bringing back fever rapidly prepared in example 1 again at night for 12 o' clock, make the body sweat all over, and take the next day for bringing back fever and safety.
9. Pengzhi, female, 3.5 years old, fever 2-3 days, using Western medicines to suspend water, antipyretic, no fever and cough, taking 20ml of the quick antipyretic Chinese medicinal composition prepared in example 1, the fever abates immediately the next day, and the cough is also good.
10. A certain forest, a man and an adult generate heat for 3 days, hang water, eat western medicines for three days, do not use the western medicines, do not lift the head, eat nothing for several days, do not want to eat, test the heat in western medicines for no heat, take 25ml of the traditional Chinese medicine composition for quickly abating the heat prepared in the embodiment 1 for about 10 minutes, namely, the eyebrow is spread and the face is beautified, the feeling is more comfortable, and then take 10ml of the traditional Chinese medicine composition for quickly abating the heat prepared in the embodiment 1 for 2 times, so that the consolidation and the relapse prevention are realized.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.

Claims (8)

1. A traditional Chinese medicine composition for rapidly abating fever is characterized in that: the traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 3-7 parts of scutellaria baicalensis, 40-60 parts of radix rehmanniae, 20-40 parts of gypsum, 1-3 parts of coptis chinensis, 3-7 parts of medlar, 10-20 parts of radix bupleuri, 10-20 parts of phellodendron amurense, 15-25 parts of glossy privet fruit, 2-4 parts of divaricate saposhnikovia root, 5-15 parts of gardenia, 20-30 parts of rhizoma anemarrhenae, 2-4 parts of radix angelicae, 5-9 parts of gentian, 20-40 parts of astragalus membranaceus, 1-3 parts of cassia twig, 15-25 parts of cassia seed, 10-20 parts of poria cocos, 2-4 parts of schizonepeta, 10-20 parts of radix puerariae and 2-4 parts of radix clematidis; the preparation method of the traditional Chinese medicine composition for rapidly abating fever comprises the following steps: s1, screening out high-quality raw material components, cleaning, and drainingMoisture and drying to prepare dried raw material components; s2, crushing the dried raw material components to obtain raw material component powder; s3, adding water into the raw material component powder, soaking, heating and extracting, filtering, repeatedly extracting for 5 times, mixing water extracting solutions obtained by 5 times of extraction, and preparing a mixed water extracting solution and residues; s4, performing supercritical CO treatment on the residues2Extracting to obtain supercritical CO2Extracting with mixed water solution of supercritical CO2Mixing the extractive solutions, and concentrating under reduced pressure to obtain the Chinese medicinal composition with rapid antipyretic effect.
2. The rapid antipyretic traditional Chinese medicine composition according to claim 1, which is characterized in that: the traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 4-6 parts of scutellaria baicalensis, 45-55 parts of radix rehmanniae, 25-35 parts of gypsum, 1.5-2.5 parts of coptis chinensis, 4-6 parts of medlar, 13-17 parts of radix bupleuri, 13-17 parts of phellodendron, 13-22 parts of glossy privet fruit, 2.5-3.5 parts of divaricate saposhnikovia root, 8-12 parts of gardenia, 23-27 parts of rhizoma anemarrhenae, 2.5-3.5 parts of angelica dahurica, 6-8 parts of gentian, 25-35 parts of astragalus mongholicus, 1.5-2.5 parts of cassia twig, 18-22 parts of semen cassiae, 13-18 parts of poria cocos, 2.5-3.5 parts of schizonepeta, 13-17 parts of radix puerariae and 2.5-3.5 parts of radix clematidis.
3. The rapid antipyretic traditional Chinese medicine composition according to claim 2, which is characterized in that: the traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 5 parts of scutellaria baicalensis, 50 parts of radix rehmanniae, 30 parts of gypsum, 2 parts of coptis chinensis, 5 parts of medlar, 15 parts of radix bupleuri, 15 parts of golden cypress, 20 parts of glossy privet fruit, 3 parts of divaricate saposhnikovia root, 10 parts of cape jasmine, 25 parts of rhizoma anemarrhenae, 3 parts of radix angelicae, 7 parts of gentian, 30 parts of astragalus mongholicus, 2 parts of cassia twig, 20 parts of semen cassiae, 15 parts of poria cocos, 3 parts of schizonepeta, 15 parts of radix puerariae and 3 parts of radix clematidis.
4. The rapid antipyretic traditional Chinese medicine composition according to claim 2, which is characterized in that: the traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 4 parts of scutellaria baicalensis, 45 parts of radix rehmanniae, 25 parts of gypsum, 1.5 parts of coptis chinensis, 4 parts of medlar, 13 parts of radix bupleuri, 13 parts of golden cypress, 13 parts of glossy privet fruit, 2.5 parts of divaricate saposhnikovia root, 8 parts of cape jasmine fruit, 23 parts of rhizoma anemarrhenae, 2.5 parts of radix angelicae, 6 parts of gentian, 25 parts of astragalus mongholicus, 1.5 parts of cassia twig, 18 parts of semen cassiae, 13 parts of poria cocos, 2.5 parts of schizonepeta, 13 parts of radix puerariae and 2.5 parts of radix clematidis.
5. The rapid antipyretic traditional Chinese medicine composition according to claim 2, which is characterized in that: the traditional Chinese medicine composition for rapidly abating fever comprises the following raw material components in parts by weight: 6 parts of scutellaria baicalensis, 55 parts of radix rehmanniae, 35 parts of gypsum, 2.5 parts of coptis chinensis, 6 parts of medlar, 17 parts of radix bupleuri, 17 parts of golden cypress, 22 parts of glossy privet fruit, 3.5 parts of divaricate saposhnikovia root, 12 parts of cape jasmine fruit, 27 parts of rhizoma anemarrhenae, 3.5 parts of radix angelicae, 8 parts of gentian, 35 parts of astragalus mongholicus, 2.5 parts of cassia twig, 22 parts of semen cassiae, 18 parts of poria cocos, 3.5 parts of schizonepeta, 17 parts of radix puerariae and 3.5 parts of radix clematidis.
6. The rapid antipyretic traditional Chinese medicine composition according to claim 1, which is characterized in that: in step S3, the mass ratio of the raw material component powder to water is 1: 15-20 parts of; the heating extraction is heating to 100-120 ℃ for 1 hour.
7. The rapid antipyretic traditional Chinese medicine composition according to claim 1, which is characterized in that: in step S4, the supercritical CO is2The extraction conditions are 45MPa pressure and 45 ℃.
8. The rapid antipyretic traditional Chinese medicine composition according to claim 1, which is characterized in that: in step S4, the mixture is concentrated to a relative density of 0.9-1.3 under the reduced pressure of-0.08 to-0.1 MPa.
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