CN104547836A - Traditional Chinese medicine composition for treating senile dementia - Google Patents
Traditional Chinese medicine composition for treating senile dementia Download PDFInfo
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- CN104547836A CN104547836A CN201510073807.2A CN201510073807A CN104547836A CN 104547836 A CN104547836 A CN 104547836A CN 201510073807 A CN201510073807 A CN 201510073807A CN 104547836 A CN104547836 A CN 104547836A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating senile dementia, relates to the field of treatment of senile dementia, and mainly aims at solving the problems that the existing medicines for treating senile dementia cannot treat both symptoms and root causes, and have side effects. The composition is prepared from the following raw materials in parts by weight: 15-30 parts of ligusticum wallichii, 5-25 parts of walnut kernel, 10-30 parts of fructus alpinia oxyphylla, 5-20 parts of polygonum multiflorum, 15-30 parts of gingkgo, 10-25 parts of rhodiola rosea, 10-25 parts of semen platycladi, 5-25 parts of tuber fleeceflower stem, 10-25 parts of polygala tenuifolia, 5-25 parts of rhizoma anemarrhenae, 10-25 parts of wolfberry fruit, 5-25 parts of angelica sinensis ,15-35 parts of asparagus cochinchinensis, 5-25 parts of cortex phellodendri, 10-25 parts of fructus psoraleae, 5-20 parts of Chinese yam, 5-25 parts of longan, 10-25 parts of radix ophiopogonis, 5-25 parts of rhizoma atractylodis macrocephalae and 15-30 parts of liquorice. The traditional Chinese medicine composition is capable of promoting the senile dementia symptoms to disappear; and the total effective rate on treatment of the senile dementia is more than or equal to 98%.
Description
Technical field
The present invention relates to treatment alzheimer disease technical field, specifically a kind of Chinese medicine composition for the treatment of alzheimer disease.
Background technology
Alzheimer disease is also called Alzheimer, and it is the nervous system degenerative disease of the Progressive symmetric erythrokeratodermia development of a kind of onset concealment.Feature is shown as clinically with dysmnesia, aphasia, apraxia, agnosia, the infringement of visual space technical ability, n-back test obstacle and the generalized dementia such as personality and behavior change.The traditional Chinese medical science thinks that primary disease can sum up four kinds of cruxs: the first is hindered for spleen kidney two, insufficiency of the spleen then transformation failure of spleen, then the source of vital function is deficient, occurs fatigue and weakness, deficiency of QI with disinclination to talk; The second is combination of phlegm and heat, and clear key certainly fills in gerontal patient due to lung, spleen, all dirty deteriorations of kidney, and three Jiao lose in logical tune, water is wet stops that poly-to form expectorant turbid, or fat wet Sheng, or rich and fatty diet, alcoholism internal injury, all can accumulatively wet raise phlegm, combination of phlegm and heat, above disturbs key clearly, then depending on, listen, aphasis; The third is deficiency of spleen-YANG and kidneyYANG, the hollow insufficiency of kidney-YANG of brains, and the gate of vitality is on the decline, YANG failing to warm spleen-YANG, dysfunction of the spleen in transportation, for a long time then deficiency of spleen and stomach, and with the passing of time deficient, yang-energy is on the decline, and disease sees dull-witted Mental fatigue, reticent aphasia; 4th kind is that all stagnation of QI blood vessels are not smooth for liver, and stop in blood stasis, brain network is obstructed, and brain is lost and supported, then depending on, listen, say, memory dysfunction, feelings will activity exception, dull spirit, bradykinesia, insomnia forgetfulness.Current doctor trained in Western medicine there is no specific short to alzheimer disease, many employings suppress for many with anxiety for oral administration, depressed medicine temporarily, as alprazolam, oxazepam, maprotiline etc., but can only relief of symptoms, can not effect a radical cure, and there is certain side effect, thus add treatment difficulty, use exists certain drawback.
Summary of the invention
The object of the invention is to overcome the above problems, and treating both the principal and secondary aspects of a disease is provided, a kind of Chinese medicine composition for the treatment of alzheimer disease had no side effect.
The technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 15 ~ 30 parts, Semen Juglandis 5 ~ 25 parts, Fructus Alpiniae Oxyphyllae 10 ~ 30 parts, Radix Polygoni Multiflori 5 ~ 20 parts, Semen Ginkgo 15 ~ 30 parts, Radix Rhodiolae 10 ~ 25 parts, Semen Platycladi 10 ~ 25 parts, Caulis Polygoni Multiflori 5 ~ 25 parts, Radix Polygalae 10 ~ 25 parts, the Rhizoma Anemarrhenae 5 ~ 25 parts, Fructus Lycii 10 ~ 25 parts, Radix Angelicae Sinensis 5 ~ 25 parts, Radix Asparagi 15 ~ 35 parts, Cortex Phellodendri 5 ~ 25 parts, Fructus Psoraleae 10 ~ 25 parts, Rhizoma Dioscoreae 5 ~ 20 parts, Arillus Longan 5 ~ 25 parts, Radix Ophiopogonis 10 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 25 parts, 15 ~ 30 parts, Radix Glycyrrhizae.
Further, a kind of Chinese medicine composition for the treatment of alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 20 ~ 25 parts, Semen Juglandis 10 ~ 20 parts, Fructus Alpiniae Oxyphyllae 5 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Semen Ginkgo 20 ~ 25 parts, Radix Rhodiolae 15 ~ 20 parts, Semen Platycladi 15 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Polygalae 15 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, Fructus Lycii 15 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Radix Asparagi 20 ~ 30 parts, Cortex Phellodendri 10 ~ 20 parts, Fructus Psoraleae 15 ~ 20 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Arillus Longan 10 ~ 20 parts, Radix Ophiopogonis 15 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 20 ~ 25 parts, Radix Glycyrrhizae.
Further, treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 23 parts, Semen Juglandis 15 parts, Fructus Alpiniae Oxyphyllae 16 parts, Radix Polygoni Multiflori 12 parts, Semen Ginkgo 22 parts, Radix Rhodiolae 18 parts, Semen Platycladi 17 parts, Caulis Polygoni Multiflori 15 parts, Radix Polygalae 18 parts, the Rhizoma Anemarrhenae 13 parts, Fructus Lycii 11 parts, Radix Angelicae Sinensis 14 parts, Radix Asparagi 15 parts, Cortex Phellodendri 14 parts, Fructus Psoraleae 19 parts, Rhizoma Dioscoreae 11 parts, Arillus Longan 13 parts, Radix Ophiopogonis 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 21 parts, Radix Glycyrrhizae.
Further, a kind of Chinese medicine composition for the treatment of alzheimer disease, described compositions can be made into oral liquid.
Further, a kind of preparation method for the treatment of the Chinese medicine oral liquid of alzheimer disease, preparation method is as follows: crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 20 ~ 30 minutes, filter, get decoction liquor.
Instructions of taking: once a day, a 100ml 10 days is a course for the treatment of.
Medical material effect of the present invention is resolved as follows:
Rhizoma Chuanxiong acrid in the mouth, warm in nature, have activating QI to alleviate the depression, method wind-dryness is wet, effect of promoting blood circulation and stopping pain, controls air-cooled headache and revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores, for menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Semen Juglandis sweet in the mouth, warm in nature, have the kidney invigorating warming the lung, effect of loosening bowel to relieve constipation, primary treatment kidney yang deficiency, lumbago flaccidity of the lower limbs, frequent micturition, lung kidney deficiency, deficiency and coldness is breathed with cough, chronic cough of deficiency lung, asthma, dryness of the intestine constipation.Fructus Alpiniae Oxyphyllae acrid in the mouth, warm in nature, have temperature compensation astringency inducing, warm spleen antidiarrheal, Gu Dan takes the photograph saliva, effect of the kidney warming controlling nocturnal emission with astringent drugs reducing urination, cures mainly spleen-kidney vacuity cold, abdominal pain diarrhea, or kidney qi deficiency and coldness frequent micturition, the enuresis, passes out semen, nebulousurine; Or saliva outflow and can not effector in chronic diarrhea caused by Deficiency and coldness of spleen and stomach and mouth.Radix Polygoni Multiflori bitter in the mouth, slightly warm in nature, there is nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, the effect of dispeling the wind, detoxifying, the empty Light-headedness of primary treatment, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid.Semen Ginkgo sweet in the mouth, property is put down, and have and astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, effect of pain relieving, is mainly used in cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia, and anticoagulant is solid, has certain probability to improve memory.Radix Rhodiolae sweet in the mouth, hardship, property is put down, and have benefiting QI for activating blood circulation, effect of relievining asthma of promoting blood circulation, is mainly used in blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, and asthenia is panted.Semen Platycladi sweet in the mouth, property is flat has tranquilizing by nourishing the heart, effect of loosening bowel to relieve constipation, for restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.Caulis Polygoni Multiflori sweet and slightly bitter taste, property is put down, and has and nourishes heart, calm the nerves, dredging collateral, the effect of dispeling the wind, primary treatment insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Radix Polygalae bitter in the mouth, warm in nature, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Rhizoma Anemarrhenae bitter in the mouth, cold in nature, have clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect, as long as treatment calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.Fructus Lycii sweet in the mouth, property are flat, have nourishing the liver and kidney, replenishing vital essence to improve eyesight, are mainly used in deficiency of the liver and kindey, the vertigo of blood and essence asthenia, visual deterioration, the soreness of the waist and knees of the hepatic and renal YIN deficiency, seminal emission.Radix Angelicae Sinensis acrid in the mouth, sweet, warm in nature, have and enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation, be mainly used in that menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery.Radix Asparagi bitter in the mouth, property are flat, have YIN nourishing, moisturize, lung heat clearing, effect of pathogenic fire reducing, be mainly used in controlling fever due to yin deficiency, and cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Cortex Phellodendri bitter in the mouth, cold in nature, have heat clearing away, dampness, pathogenic fire purging, effect of removing toxic substances, is used for the treatment of hematodiarrhoea, has loose bowels, and quenches one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, and hemorrhoid, have blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Fructus Psoraleae bitter in the mouth, pungent, warm in nature, there is kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, effect of helping inspiration to relieve asthma, primary treatment impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition.Rhizoma Dioscoreae sweet in the mouth, property is put down, and have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission, and be mainly used in insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Arillus Longan sweet in the mouth, property are flat, have reinforcing the heart spleen, replenishing QI and blood, strengthening the spleen and stomach, support effect of muscle, for worry impairing spleen, dizzy, insomnia, severe palpitation, emptyly win, and after being ill or puerperal asthenia, and to lose blood disease due to insufficiency of the spleen caused hematochezia.Radix Ophiopogonis sweet in the mouth, cold nature, has YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, be mainly used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Radix Glycyrrhizae sweet in the mouth, property are flat, and it contains number of chemical composition, and effect is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain.
The present invention has following beneficial effect:
(1) Rhizoma Chuanxiong activating QI to alleviate the depression, method wind-dryness are wet, Semen Juglandis the kidney invigorating warming the lung, loosening bowel to relieve constipation, Fructus Alpiniae Oxyphyllae temperature compensation astringency inducing, Gu Dan takes the photograph saliva, Radix Polygoni Multiflori nourishing the blood and yin, removing toxic substances of dispeling the wind, Semen Ginkgo is astringed the lung and relievings asthma, blood circulation promoting and blood stasis dispelling, Radix Rhodiolae has benefiting QI for activating blood circulation, promote blood circulation the effect of relievining asthma, the ethanol extract of Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae has good scavenging action to DPPH.free radical, alleviates brain and mends and degenerate; Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation, hand over rattan tranquilizing by nourishing the heart, dredging collateral, dispel the wind, Radix Polygalae is calmed the nerves Fructus Alpiniae Oxyphyllae, eliminating phlegm for diminishing swelling, Rhizoma Anemarrhenae clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight, Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, can effectively anti-worry, the calm mind, regulates sleep, the diseases such as relieving insomnia is impatient, and can enrich blood and invigorate blood circulation; Radix Asparagi is nourshing Yin and drynsessmoistening prescription, lung heat clearing pathogenic fire reducing, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, Fructus Psoraleae kidney invigorating and YANG supporting, warming spleen and stopping diarrha, helping inspiration to relieve asthma, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission, Arillus Longan reinforcing the heart spleen, replenishing QI and blood, strengthening the spleen and stomach, Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Radix Glycyrrhizae replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, effective the kidney invigorating warming the spleen, drug matching is suitable for, treating both the principal and secondary aspects of a disease, and medical material is easy to get.
(2) crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, be that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, medicine is made to be convenient to preparation and adjustment, reduce the property that the taste of medicine is greasy, correct bad smell, the function of promoting blood circulation to disperse blood clots of medicine can be strengthened, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, saline is fried afterwards and medicine plays synergism, effect of invigorating blood circulation of enriching blood can be strengthened, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae and Testa Tritici weight ratio are that 10:1 adds Testa Tritici and carries out smoked stir-fry, through Testa Tritici smoke stir-fry can heat-clearing and toxic substances removing, the kidney invigorating warming the spleen effect, and the effectiveness of medicine can be given full play to, medicine after process decocts through grinding again, and middle the effective elements of the medicine is freely flowed out, and what be conducive to drug effect gives full play to utilization.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 15 parts, Semen Juglandis 5 parts, Fructus Alpiniae Oxyphyllae 10 parts, Radix Polygoni Multiflori 5 parts, Semen Ginkgo 15 parts, Radix Rhodiolae 10 parts, Semen Platycladi 10 parts, Caulis Polygoni Multiflori 5 parts, Radix Polygalae 10 parts, the Rhizoma Anemarrhenae 5 parts, Fructus Lycii 10 parts, Radix Angelicae Sinensis 5 parts, Radix Asparagi 15 parts, Cortex Phellodendri 5 parts, Fructus Psoraleae 10 parts, Rhizoma Dioscoreae 5 parts, Arillus Longan 5 parts, Radix Ophiopogonis 10 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 15 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 20 minutes, filter, get decoction liquor, once a day, a 100ml.
Embodiment 2:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 30 parts, Semen Juglandis 25 parts, Fructus Alpiniae Oxyphyllae 30 parts, Radix Polygoni Multiflori 20 parts, Semen Ginkgo 30 parts, Radix Rhodiolae 25 parts, Semen Platycladi 25 parts, Caulis Polygoni Multiflori 25 parts, Radix Polygalae 25 parts, the Rhizoma Anemarrhenae 25 parts, Fructus Lycii 25 parts, Radix Angelicae Sinensis 25 parts, Radix Asparagi 35 parts, Cortex Phellodendri 25 parts, Fructus Psoraleae 25 parts, Rhizoma Dioscoreae 20 parts, Arillus Longan 25 parts, Radix Ophiopogonis 25 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, 30 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 30 minutes, filter, get decoction liquor, once a day, a 100ml.
Embodiment 3:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 20 parts, Semen Juglandis 10 parts, Fructus Alpiniae Oxyphyllae 5 parts, Radix Polygoni Multiflori 10 parts, Semen Ginkgo 20 parts, Radix Rhodiolae 15 parts, Semen Platycladi 15 parts, Caulis Polygoni Multiflori 10 parts, Radix Polygalae 15 parts, the Rhizoma Anemarrhenae 10 parts, Fructus Lycii 15 parts, Radix Angelicae Sinensis 10 parts, Radix Asparagi 20 parts, Cortex Phellodendri 10 parts, Fructus Psoraleae 15 parts, Rhizoma Dioscoreae 10 parts, Arillus Longan 10 parts, Radix Ophiopogonis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 20 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 25 minutes, filter, get decoction liquor, once a day, a 100ml.
Embodiment 4:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 25 parts, Semen Juglandis 20 parts, Fructus Alpiniae Oxyphyllae 25 parts, Radix Polygoni Multiflori 15 parts, Semen Ginkgo 25 parts, Radix Rhodiolae 20 parts, Semen Platycladi 20 parts, Caulis Polygoni Multiflori 20 parts, Radix Polygalae 20 parts, the Rhizoma Anemarrhenae 20 parts, Fructus Lycii 20 parts, Radix Angelicae Sinensis 20 parts, Radix Asparagi 30 parts, Cortex Phellodendri 20 parts, Fructus Psoraleae 20 parts, Rhizoma Dioscoreae 15 parts, Arillus Longan 20 parts, Radix Ophiopogonis 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, 25 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 22 minutes, filter, get decoction liquor, once a day, a 100ml.
Embodiment 5:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 23 parts, Semen Juglandis 15 parts, Fructus Alpiniae Oxyphyllae 16 parts, Radix Polygoni Multiflori 12 parts, Semen Ginkgo 22 parts, Radix Rhodiolae 18 parts, Semen Platycladi 17 parts, Caulis Polygoni Multiflori 15 parts, Radix Polygalae 18 parts, the Rhizoma Anemarrhenae 13 parts, Fructus Lycii 11 parts, Radix Angelicae Sinensis 14 parts, Radix Asparagi 15 parts, Cortex Phellodendri 14 parts, Fructus Psoraleae 19 parts, Rhizoma Dioscoreae 11 parts, Arillus Longan 13 parts, Radix Ophiopogonis 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 21 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 28 minutes, filter, get decoction liquor, once a day, a 100ml.
Embodiment 6:
Treat a Chinese medicine composition for alzheimer disease, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 15 parts, Semen Juglandis 25 parts, Fructus Alpiniae Oxyphyllae 12 parts, Radix Polygoni Multiflori 25 parts, Semen Ginkgo 21 parts, Radix Rhodiolae 23 parts, Semen Platycladi 15 parts, Caulis Polygoni Multiflori 17 parts, Radix Polygalae 20 parts, the Rhizoma Anemarrhenae 5 parts, Fructus Lycii 11 parts, Radix Angelicae Sinensis 5 parts, Radix Asparagi 17 parts, Cortex Phellodendri 9 parts, Fructus Psoraleae 16 parts, Rhizoma Dioscoreae 16 parts, Arillus Longan 18 parts, Radix Ophiopogonis 21 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 30 parts, Radix Glycyrrhizae.
Crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 30 minutes, filter, get decoction liquor, once a day, a 100ml.
Medicine of the present invention has carried out zoopery and clinical research, and its result is described below:
1, zoopery
Animal acute toxicity experiment, selects white mice 40, each 20 of male and female, sodium carboxymethyl cellulose solution with 1% makes the suspension of 50mg/ml, gavage body 0.56ml/10g, every day three times, observe animal activity after gavage 15 days, diet, feces, hair color and death condition, the results are shown in Table 1.
Animal acute toxicity experiment result:
Table 1
After experimental result gavage, the diet of animal, feces, none example of hair are abnormal, and after second, third gavage, much more slightly animal moves, and within about 10 minutes, the many emotionally conditions of animal disappear, and none example was dead on 15th.
Conclusion: maximum tolerated dose is ﹥ 7.35mg/kg is 147 times of the clinical maximal dose of people.
2, clinical data and case:
In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine patients with Alzheimer diseases, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.
Clinical therapeutic efficacy criterion is:
Cure: common symptom have forgetful, apathetic expression, bradykinesia, lazy language, drowsiness, easily shy, be slow in action, two dyschezia controls, head incline, and the back of the body is bent, making an indiscreet remark smooth etc. all disappears.
Take a turn for the better: common sympton have forgetful, apathetic expression, bradykinesia, lazy language, drowsiness, easily shy, be slow in action, two dyschezia controls, head incline, and the back of the body is bent, smooth etc. substantially to disappear of making an indiscreet remark.
Invalid: symptom is not improved.
Therapeutic effect: the present invention is through treating 100 routine patients with Alzheimer diseases, and 98 examples take a turn for the better, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.
Model case:
Case 1: patient Jiang, female, 72 years old, patient was forgetful, apathetic expression, bradykinesia, lazy language, drowsiness, and after using 4 courses for the treatment of of Chinese medicine composition of the present invention, symptom obviously alleviates, and continue 3 courses for the treatment of of use, behavior initiative strengthens, and thinking is clear.
Case 2: patient Lee, man, 68 years old, patient is forgetful, apathetic expression, bradykinesia, easily shy, be slow in action, two dyschezia controls, head inclines, and the back of the body is bent, smoothness of making an indiscreet remark, after using 3 courses for the treatment of of Chinese medicine composition of the present invention, the indifferent symptom such as to shrink back obviously is improved, continue 5 courses for the treatment of of use, speaking to oneself from laughing at control, can participate in collective activity, language performance is smooth.
Case 3: patient Jiang, female, 77 years old, patient's skin is forgetful, apathetic expression, bradykinesia, lazy language, drowsiness, easily shy, be slow in action, two dyschezia controls, head inclines, and the back of the body is bent, smoothness of making an indiscreet remark, after using 5 courses for the treatment of of Chinese medicine composition of the present invention, symptom is clearly better, after continuing to use 3 courses for the treatment of of Chinese medicine composition of the present invention, convenient to both can self-contr ol, actively can exchange with people, be tending towards the length of one's sleep normal.
The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Claims (5)
1. treat the Chinese medicine composition of alzheimer disease for one kind, it is characterized in that, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 15 ~ 30 parts, Semen Juglandis 5 ~ 25 parts, Fructus Alpiniae Oxyphyllae 10 ~ 30 parts, Radix Polygoni Multiflori 5 ~ 20 parts, Semen Ginkgo 15 ~ 30 parts, Radix Rhodiolae 10 ~ 25 parts, Semen Platycladi 10 ~ 25 parts, Caulis Polygoni Multiflori 5 ~ 25 parts, Radix Polygalae 10 ~ 25 parts, the Rhizoma Anemarrhenae 5 ~ 25 parts, Fructus Lycii 10 ~ 25 parts, Radix Angelicae Sinensis 5 ~ 25 parts, Radix Asparagi 15 ~ 35 parts, Cortex Phellodendri 5 ~ 25 parts, Fructus Psoraleae 10 ~ 25 parts, Rhizoma Dioscoreae 5 ~ 20 parts, Arillus Longan 5 ~ 25 parts, Radix Ophiopogonis 10 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 5 ~ 25 parts, 15 ~ 30 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for the treatment of alzheimer disease according to claim 1, it is characterized in that, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 20 ~ 25 parts, Semen Juglandis 10 ~ 20 parts, Fructus Alpiniae Oxyphyllae 5 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 15 parts, Semen Ginkgo 20 ~ 25 parts, Radix Rhodiolae 15 ~ 20 parts, Semen Platycladi 15 ~ 20 parts, Caulis Polygoni Multiflori 10 ~ 20 parts, Radix Polygalae 15 ~ 20 parts, the Rhizoma Anemarrhenae 10 ~ 20 parts, Fructus Lycii 15 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Radix Asparagi 20 ~ 30 parts, Cortex Phellodendri 10 ~ 20 parts, Fructus Psoraleae 15 ~ 20 parts, Rhizoma Dioscoreae 10 ~ 15 parts, Arillus Longan 10 ~ 20 parts, Radix Ophiopogonis 15 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, 20 ~ 25 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of alzheimer disease according to claim 1, it is characterized in that, the crude drug effective ingredient mass fraction making compositions comprises: Rhizoma Chuanxiong 23 parts, Semen Juglandis 15 parts, Fructus Alpiniae Oxyphyllae 16 parts, Radix Polygoni Multiflori 12 parts, Semen Ginkgo 22 parts, Radix Rhodiolae 18 parts, Semen Platycladi 17 parts, Caulis Polygoni Multiflori 15 parts, Radix Polygalae 18 parts, the Rhizoma Anemarrhenae 13 parts, Fructus Lycii 11 parts, Radix Angelicae Sinensis 14 parts, Radix Asparagi 15 parts, Cortex Phellodendri 14 parts, Fructus Psoraleae 19 parts, Rhizoma Dioscoreae 11 parts, Arillus Longan 13 parts, Radix Ophiopogonis 16 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 21 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine composition for the treatment of alzheimer disease according to claim 1-3 any one, it is characterized in that, described compositions can be made into oral liquid.
5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of alzheimer disease according to claim 4, it is characterized in that, preparation process is as follows: crude drug Rhizoma Chuanxiong, Semen Juglandis, Fructus Alpiniae Oxyphyllae, Radix Polygoni Multiflori, Semen Ginkgo, Radix Rhodiolae is that 2:1 adds Pulvis concha Mactrae and carries out parch according to crude drug and Pulvis concha Mactrae weight ratio, crude drug Semen Platycladi, Caulis Polygoni Multiflori, Radix Polygalae, the Rhizoma Anemarrhenae, Fructus Lycii, Radix Angelicae Sinensis carries out salt stir-fry according to crude drug and weight saline than for 50:1 adds saline, brine strength is 20%, Radix Asparagi, Cortex Phellodendri, Fructus Psoraleae, Rhizoma Dioscoreae, Arillus Longan, Radix Ophiopogonis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae is that 10:1 adds Testa Tritici and carries out smoked stir-fry according to crude drug and Testa Tritici weight ratio, feed components after process is mixed, grind, decoct with water 20 ~ 30 minutes, filter, get decoction liquor, both.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815294A (en) * | 2015-05-26 | 2015-08-05 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine oral solution for treating chronic gastritis and preparation method thereof |
| CN107334975A (en) * | 2017-09-01 | 2017-11-10 | 广西叶茂生物科技有限公司 | A kind of medicine for treating senile dementia and preparation method thereof |
| CN111686198A (en) * | 2020-06-29 | 2020-09-22 | 新乡医学院第一附属医院 | Chinese herbal medicine composition for treating senile dementia and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005089324A (en) * | 2003-09-12 | 2005-04-07 | Sun Chlorella Corp | Caspase inhibitor |
| CN104083575A (en) * | 2014-06-03 | 2014-10-08 | 王春芳 | Traditional Chinese medicine preparation for treating senile dementia |
-
2015
- 2015-02-12 CN CN201510073807.2A patent/CN104547836A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005089324A (en) * | 2003-09-12 | 2005-04-07 | Sun Chlorella Corp | Caspase inhibitor |
| CN104083575A (en) * | 2014-06-03 | 2014-10-08 | 王春芳 | Traditional Chinese medicine preparation for treating senile dementia |
Non-Patent Citations (2)
| Title |
|---|
| 孙环宇: ""‘补智益脑汤’治疗老年性痴呆40例"", 《江苏中医药》 * |
| 陈楷等: ""中药治疗老年期痴呆初步研究进展"", 《中国中西医结合杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815294A (en) * | 2015-05-26 | 2015-08-05 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine oral solution for treating chronic gastritis and preparation method thereof |
| CN107334975A (en) * | 2017-09-01 | 2017-11-10 | 广西叶茂生物科技有限公司 | A kind of medicine for treating senile dementia and preparation method thereof |
| CN111686198A (en) * | 2020-06-29 | 2020-09-22 | 新乡医学院第一附属医院 | Chinese herbal medicine composition for treating senile dementia and preparation method thereof |
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